Detailed information for compound 154154

Basic information

Technical information
  • TDR Targets ID: 154154
  • Name: 5-methylindolo[3,2-b]quinoline hydrochloride
  • MW: 268.741 | Formula: C16H13ClN2
  • H donors: 0 H acceptors: 1 LogP: 4.13 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cn1c2ccccc2cc2c1c1ccccc1n2.Cl
  • InChi: 1S/C16H12N2.ClH/c1-18-15-9-5-2-6-11(15)10-14-16(18)12-7-3-4-8-13(12)17-14;/h2-10H,1H3;1H
  • InChiKey: PACBZNVVTJRUCN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-methyl-10H-indolo[3,2-b]quinolin-5-ium chloride
  • 5-methyl-10H-quinolino[3,2-b]indol-5-ium chloride
  • NSC357789
  • 5-methylquinolino[3,2-b]indole hydrochloride
  • 72782-09-3
  • 480-26-2
  • 5-Methyl-5H-quindoline hydrochloride
  • 5H-Quindoline, 5-methyl-, monohydrochloride
  • NSC647765
  • cryptolepine hydrochloride

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Carboxylesterase family protein 0.00782909 0.0101043 0.0101043
Loa Loa (eye worm) cytochrome P450 family protein 0.0023876 0.00168142 0.00168142
Echinococcus granulosus Solute carrier organic anion transporter family 0.00255533 0.00194104 0.00194104
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.21343 0.328355 1
Loa Loa (eye worm) hypothetical protein 0.0463354 0.0697085 0.0697085
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.00174961 0.000693863 0.000693863
Entamoeba histolytica prolyl oligopeptidase family protein 0.0454669 0.0683641 0.886642
Loa Loa (eye worm) hypothetical protein 0.00165084 0.000540978 0.000540978
Brugia malayi tubulin alpha chain - mouse 0.0360857 0.0538429 0.0538429
Leishmania major beta tubulin 0.0511135 0.0771045 0.23482
Brugia malayi bHLH-PAS transcription factor 0.00346896 0.00335526 0.00335526
Echinococcus multilocularis patatin phospholipase domain containing protein 0.00132807 0.0000413697 0.0000413697
Trypanosoma cruzi epsilon tubulin, putative 0.028202 0.0416396 0.126813
Brugia malayi hypothetical protein 0.00255533 0.00194104 0.00194104
Plasmodium vivax tubulin epsilon chain, putative 0.028202 0.0416396 0.540042
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00174961 0.000693863 0.000693863
Brugia malayi Dopamine receptor 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) neuropeptide F receptor 0.00174961 0.000693863 0.000693863
Echinococcus granulosus potassium voltage gated channel subfamily H 0.00306298 0.00272685 0.00272685
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.21343 0.328355 1
Brugia malayi tubulin alpha-2 chain 0.0360857 0.0538429 0.0538429
Echinococcus multilocularis sex peptide receptor 0.00174961 0.000693863 0.000693863
Echinococcus granulosus beta tubulin 0.0511135 0.0771045 0.0771045
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0454669 0.0683641 0.208201
Giardia lamblia Alpha-tubulin 0.0360857 0.0538429 0.698311
Loa Loa (eye worm) tubulin alpha 2 0.0238968 0.0349756 0.0349756
Echinococcus granulosus cyclic nucleotide gated cation channel 0.00132807 0.0000413697 0.0000413697
Leishmania major beta tubulin 0.0511135 0.0771045 0.23482
Echinococcus multilocularis somatostatin receptor 0.00174961 0.000693863 0.000693863
Schistosoma mansoni tubulin subunit alpha 0.0121889 0.0168529 0.0168529
Onchocerca volvulus 0.00174961 0.000693863 0.000693863
Trypanosoma cruzi hypothetical protein, conserved 0.0454669 0.0683641 0.208201
Loa Loa (eye worm) AGC/PKG protein kinase 0.00132807 0.0000413697 0.0000413697
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.00174961 0.000693863 0.000693863
Schistosoma mansoni hypothetical protein 0.00174961 0.000693863 0.000693863
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.00782909 0.0101043 0.0101043
Loa Loa (eye worm) tubulin alpha-2 chain 0.0360857 0.0538429 0.0538429
Echinococcus granulosus cyclic nucleotide gated cation channel 0.00210248 0.00124008 0.00124008
Echinococcus granulosus Tubulin alpha 1 chain 0.0360857 0.0538429 0.0538429
Leishmania major beta tubulin 0.0511135 0.0771045 0.23482
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.00210248 0.00124008 0.00124008
Echinococcus granulosus potassium voltage gated channel subfamily H 0.00936912 0.0124882 0.0124882
Brugia malayi hypothetical protein 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) beta-tubulin 0.0511135 0.0771045 0.0771045
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis G-protein coupled receptor, putative 0.00174961 0.000693863 0.000693863
Echinococcus granulosus allatostatin A receptor 0.00174961 0.000693863 0.000693863
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.00132807 0.0000413697 0.0000413697
Echinococcus multilocularis tubulin alpha chain 0.0360857 0.0538429 0.0538429
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.00132807 0.0000413697 0.0000413697
Onchocerca volvulus 0.00174961 0.000693863 0.000693863
Schistosoma mansoni tubulin subunit gamma 0.0282201 0.0416677 0.0416677
Echinococcus granulosus tubulin subunit beta 0.0511135 0.0771045 0.0771045
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0454669 0.0683641 0.0683641
Schistosoma mansoni histamine h1 receptor 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis tubulin alpha 1C chain 0.0360857 0.0538429 0.0538429
Brugia malayi prostaglandin transporter 0.00255533 0.00194104 0.00194104
Brugia malayi Carboxylesterase family protein 0.00782909 0.0101043 0.0101043
Plasmodium vivax delta tubulin, putative 0.0121889 0.0168529 0.218573
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0454669 0.0683641 0.886642
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.00174961 0.000693863 0.000693863
Schistosoma mansoni aryl hydrocarbon receptor 0.00468707 0.00524078 0.00524078
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0132914 0.0185595 0.0565226
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.00220571 0.00139987 0.0181555
Trypanosoma brucei DNA topoisomerase II beta, putative 0.00292454 0.00251255 0.00765192
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.00174961 0.000693863 0.000693863
Trypanosoma brucei tubulin gamma chain 0.0282201 0.0416677 0.126898
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis tubulin gamma 1 chain 0.0282201 0.0416677 0.0416677
Echinococcus granulosus follistatin 0.00165084 0.000540978 0.000540978
Trypanosoma brucei beta tubulin 0.0511135 0.0771045 0.23482
Loa Loa (eye worm) melatonin receptor type 1A 0.00174961 0.000693863 0.000693863
Echinococcus granulosus alpha 1A adrenergic receptor 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.00132807 0.0000413697 0.0000413697
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.00132807 0.0000413697 0.0000413697
Loa Loa (eye worm) hypothetical protein 0.0463354 0.0697085 0.0697085
Trichomonas vaginalis tubulin gamma chain, putative 0.0282201 0.0416677 0.540405
Echinococcus granulosus tubulin beta 1 chain 0.0511135 0.0771045 0.0771045
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) hypothetical protein 0.00782909 0.0101043 0.0101043
Toxoplasma gondii beta-1 tubulin, putative 0.0511135 0.0771045 0.23482
Plasmodium falciparum DNA topoisomerase 2 0.00324888 0.0030146 0.0390976
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.00324888 0.0030146 0.0030146
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Leishmania major protein kinase, putative 0.00132807 0.0000413697 0.000125991
Loa Loa (eye worm) hypothetical protein 0.0360857 0.0538429 0.0538429
Echinococcus multilocularis dro:myosuppressin receptor 0.00174961 0.000693863 0.000693863
Entamoeba histolytica tubulin alpha chain, putative 0.0360857 0.0538429 0.698311
Trichomonas vaginalis tubulin alpha chain, putative 0.0149106 0.0210658 0.273211
Trypanosoma brucei beta tubulin 0.0511135 0.0771045 0.23482
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.00132807 0.0000413697 0.000125991
Echinococcus multilocularis fmrfamide receptor 0.00174961 0.000693863 0.000693863
Giardia lamblia Thymus-specific serine protease precursor 0.00220571 0.00139987 0.0181555
Loa Loa (eye worm) hypothetical protein 0.0211752 0.0307628 0.0307628
Echinococcus granulosus carboxylesterase 5A 0.0463354 0.0697085 0.0697085
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.00220571 0.00139987 0.0181555
Echinococcus multilocularis transfer RNA-Lys 0.00346896 0.00335526 0.00335526
Echinococcus multilocularis Tubulin alpha 1 chain 0.0360857 0.0538429 0.0538429
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0454669 0.0683641 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0511135 0.0771045 0.0771045
Trypanosoma brucei alpha tubulin 0.0360857 0.0538429 0.163978
Loa Loa (eye worm) hypothetical protein 0.00782909 0.0101043 0.0101043
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.00210248 0.00124008 0.00124008
Echinococcus granulosus fmrfamide receptor 0.00174961 0.000693863 0.000693863
Leishmania major beta tubulin 0.0511135 0.0771045 0.23482
Trypanosoma cruzi cAMP response protein 1, putative 0.00132807 0.0000413697 0.000125991
Trypanosoma brucei epsilon tubulin 0.0270995 0.0399331 0.121615
Trichomonas vaginalis tubulin gamma chain, putative 0.0121889 0.0168529 0.218573
Giardia lamblia Beta tubulin 0.0511135 0.0771045 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.00220571 0.00139987 0.0181555
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.00132807 0.0000413697 0.000125991
Brugia malayi Carboxylesterase family protein 0.0463354 0.0697085 0.0697085
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis neuropeptide s receptor 0.00174961 0.000693863 0.000693863
Echinococcus granulosus patatin phospholipase domain containing protein 0.00132807 0.0000413697 0.0000413697
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.00306298 0.00272685 0.00272685
Schistosoma mansoni amine GPCR 0.00174961 0.000693863 0.000693863
Onchocerca volvulus 0.00255533 0.00194104 0.00194104
Echinococcus granulosus tubulin alpha 1C chain 0.0360857 0.0538429 0.0538429
Echinococcus multilocularis rhodopsin orphan GPCR 0.00174961 0.000693863 0.000693863
Echinococcus granulosus tachykinin peptides receptor 99D 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) hypothetical protein 0.0418661 0.0627904 0.0627904
Loa Loa (eye worm) hypothetical protein 0.00220571 0.00139987 0.00139987
Echinococcus granulosus Tubulin beta 2C chain 0.0511135 0.0771045 0.0771045
Brugia malayi Cytochrome P450 family protein 0.0023876 0.00168142 0.00168142
Echinococcus granulosus serotonin receptor 0.00174961 0.000693863 0.000693863
Giardia lamblia Alpha-tubulin 0.0360857 0.0538429 0.698311
Leishmania major beta tubulin 0.0511135 0.0771045 0.23482
Brugia malayi secreted modular calcium-binding protein 1 0.00165084 0.000540978 0.000540978
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.21343 0.328355 1
Echinococcus granulosus g protein coupled receptor 0.00174961 0.000693863 0.000693863
Brugia malayi sodium-independent organic anion transporter family protein 0.00255533 0.00194104 0.00194104
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00174961 0.000693863 0.000693863
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.00132807 0.0000413697 0.000536541
Brugia malayi prolyl oligopeptidase family protein 0.21343 0.328355 0.328355
Schistosoma mansoni neuropeptide f receptor 76f 0.00174961 0.000693863 0.000693863
Trypanosoma brucei alpha tubulin 0.0360857 0.0538429 0.163978
Leishmania major beta tubulin 0.0511135 0.0771045 0.23482
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.647336 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00174961 0.000693863 0.000693863
Trypanosoma brucei alpha tubulin 0.0360857 0.0538429 0.163978
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Echinococcus granulosus 7tm_1 domain containing protein 0.00174961 0.000693863 0.000693863
Schistosoma mansoni tubulin subunit beta 0.0511135 0.0771045 0.0771045
Plasmodium vivax tubulin alpha chain, putative 0.0360857 0.0538429 0.698311
Trypanosoma cruzi zeta tubulin, putative 0.0234894 0.034345 0.104597
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.00210248 0.00124008 0.0160831
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.00695217 0.00874694 0.00874694
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.00695217 0.00874694 0.113443
Loa Loa (eye worm) carboxylesterase 0.0463354 0.0697085 0.0697085
Brugia malayi follicle stimulating hormone receptor 0.00174961 0.000693863 0.000693863
Trypanosoma brucei cytochrome P450, putative 0.0023876 0.00168142 0.00512073
Onchocerca volvulus DNA topoisomerase 2 homolog 0.002363 0.00164333 0.00164333
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0360857 0.0538429 0.698311
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.00220571 0.00139987 0.0181555
Schistosoma mansoni tubulin subunit beta 0.0121889 0.0168529 0.0168529
Brugia malayi Tubulin alpha chain 0.0360857 0.0538429 0.0538429
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.647336 1 1
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.00210248 0.00124008 0.00124008
Leishmania major alpha tubulin 0.0360857 0.0538429 0.163978
Brugia malayi DNA topoisomerase II, alpha isozyme 0.00324888 0.0030146 0.0030146
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.00132807 0.0000413697 0.0000413697
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.00132807 0.0000413697 0.0000413697
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0454669 0.0683641 0.0683641
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis tubulin beta 1 chain 0.0511135 0.0771045 0.0771045
Leishmania major epsilon tubulin, putative 0.028202 0.0416396 0.126813
Giardia lamblia Beta tubulin 0.0511135 0.0771045 1
Leishmania major hypothetical protein, unknown function 0.00132807 0.0000413697 0.000125991
Leishmania major beta tubulin 0.0511135 0.0771045 0.23482
Toxoplasma gondii protease inhibitor PI2 0.00165084 0.000540978 0.00164754
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.00132807 0.0000413697 0.0000413697
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0454669 0.0683641 0.0683641
Brugia malayi hypothetical protein 0.00174961 0.000693863 0.000693863
Onchocerca volvulus 0.00255533 0.00194104 0.00194104
Echinococcus multilocularis rhodopsin orphan GPCR 0.00174961 0.000693863 0.000693863
Entamoeba histolytica prolyl oligopeptidase family protein 0.0454669 0.0683641 0.886642
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.00782909 0.0101043 0.0101043
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.00695217 0.00874694 0.113443
Leishmania major beta tubulin 0.0511135 0.0771045 0.23482
Leishmania major alpha tubulin 0.0360857 0.0538429 0.163978
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.00132807 0.0000413697 0.000536541
Trypanosoma cruzi epsilon tubulin, putative 0.028202 0.0416396 0.126813
Echinococcus granulosus tubulin alpha 1C chain 0.0360857 0.0538429 0.0538429
Loa Loa (eye worm) cytochrome P450 family protein 0.0023876 0.00168142 0.00168142
Brugia malayi Cytochrome P450 family protein 0.0023876 0.00168142 0.00168142
Echinococcus granulosus tubulin gamma 1 chain 0.0282201 0.0416677 0.0416677
Mycobacterium tuberculosis Carboxylesterase LipT 0.00782909 0.0101043 0.147286
Loa Loa (eye worm) BEN-1 protein 0.0511135 0.0771045 0.0771045
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0454669 0.0683641 0.208201
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.00210248 0.00124008 0.00124008
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Onchocerca volvulus Putative organic anion transporter 0.00255533 0.00194104 0.00194104
Echinococcus multilocularis Tubulin beta 2C chain 0.0511135 0.0771045 0.0771045
Echinococcus granulosus Tubulin alpha 1 chain 0.0360857 0.0538429 0.0538429
Trichomonas vaginalis tubulin beta chain, putative 0.0149106 0.0210658 0.273211
Echinococcus multilocularis tubulin alpha 1C chain 0.0360857 0.0538429 0.0538429
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00174961 0.000693863 0.000693863
Leishmania major zeta tubulin, putative 0.0234894 0.034345 0.104597
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00174961 0.000693863 0.000693863
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0454669 0.0683641 0.208201
Brugia malayi Cell division protein ftsZ 0.0229127 0.0334524 0.0334524
Schistosoma mansoni neuropeptide F-like receptor 0.00174961 0.000693863 0.000693863
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0332103 0.049392 0.5
Leishmania major alpha tubulin 0.0360857 0.0538429 0.163978
Plasmodium falciparum tubulin delta chain, putative 0.0121889 0.0168529 0.218573
Schistosoma mansoni voltage-gated potassium channel 0.00210248 0.00124008 0.00124008
Trichomonas vaginalis tubulin epsilon chain, putative 0.0360857 0.0538429 0.698311
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0454669 0.0683641 0.208201
Loa Loa (eye worm) prolyl oligopeptidase 0.647336 1 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.00565082 0.00673257 0.0873175
Brugia malayi putative neuropeptide receptor 0.00174961 0.000693863 0.000693863
Mycobacterium leprae cell division protein FtsZ 0.0332103 0.049392 0.722316
Giardia lamblia Epsilon tubulin 0.0132914 0.0185595 0.240706
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.00174961 0.000693863 0.000693863
Brugia malayi prolyl oligopeptidase family protein 0.0454669 0.0683641 0.0683641
Echinococcus granulosus prolyl endopeptidase 0.0454669 0.0683641 0.0683641
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis neuropeptide Y receptor 0.00174961 0.000693863 0.000693863
Leishmania major beta tubulin 0.0511135 0.0771045 0.23482
Leishmania major mitochondrial DNA topoisomerase II 0.00253377 0.00190767 0.00580978
Trypanosoma cruzi DNA topoisomerase II, putative 0.00292454 0.00251255 0.00765192
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) tubulin alpha-3 chain 0.0211752 0.0307628 0.0307628
Echinococcus multilocularis g-protein coupled receptor 0.00174961 0.000693863 0.000693863
Schistosoma mansoni biogenic amine receptor 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.00174961 0.000693863 0.000693863
Leishmania major alpha tubulin 0.0360857 0.0538429 0.163978
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.00132807 0.0000413697 0.000125991
Echinococcus multilocularis expressed protein 0.00165084 0.000540978 0.000540978
Schistosoma mansoni voltage-gated potassium channel 0.0103296 0.0139749 0.0139749
Schistosoma mansoni tubulin subunit beta 0.0511135 0.0771045 0.0771045
Entamoeba histolytica tubulin family protein 0.0511135 0.0771045 1
Brugia malayi Carboxylesterase family protein 0.00782909 0.0101043 0.0101043
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.00165084 0.000540978 0.000540978
Schistosoma mansoni agrin 0.00165084 0.000540978 0.000540978
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.00165084 0.000540978 0.00164754
Loa Loa (eye worm) carboxylesterase 0.00782909 0.0101043 0.0101043
Loa Loa (eye worm) hypothetical protein 0.167963 0.257977 0.257977
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Echinococcus granulosus neuroligin 0.00782909 0.0101043 0.0101043
Leishmania major beta tubulin 0.0511135 0.0771045 0.23482
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.00782909 0.0101043 0.0101043
Onchocerca volvulus 0.00255533 0.00194104 0.00194104
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.00220571 0.00139987 0.00426328
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.00210248 0.00124008 0.00124008
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.00695217 0.00874694 0.00874694
Brugia malayi Probable DNA topoisomerase II 0.00324888 0.0030146 0.0030146
Schistosoma mansoni biogenic amine (5HT) receptor 0.00174961 0.000693863 0.000693863
Schistosoma mansoni voltage-gated potassium channel 0.00306298 0.00272685 0.00272685
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.647336 1 1
Leishmania major alpha tubulin 0.0360857 0.0538429 0.163978
Echinococcus multilocularis Tubulin beta 2C chain 0.0511135 0.0771045 0.0771045
Schistosoma mansoni serine/threonine protein kinase 0.00132807 0.0000413697 0.0000413697
Trypanosoma cruzi cytochrome P450, putative 0.0023876 0.00168142 0.00512073
Loa Loa (eye worm) tubulin beta-4 chain 0.0511135 0.0771045 0.0771045
Schistosoma mansoni amine GPCR 0.00174961 0.000693863 0.000693863
Schistosoma mansoni biogenic amine (5HT) receptor 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) prolyl oligopeptidase 0.0454669 0.0683641 0.0683641
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.00220571 0.00139987 0.00139987
Brugia malayi G protein-coupled receptor 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis Tubulin alpha 1 chain 0.0360857 0.0538429 0.0538429
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0511135 0.0771045 0.0771045
Onchocerca volvulus 0.00346896 0.00335526 0.00335526
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0189752 0.0273575 0.0833166
Brugia malayi Tachykinin-like peptides receptor 99D 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.00210248 0.00124008 0.00124008
Schistosoma mansoni opsin-like receptor 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) hypothetical protein 0.00782909 0.0101043 0.0101043
Loa Loa (eye worm) hypothetical protein 0.00145099 0.000231634 0.000231634
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Schistosoma mansoni opsin-like receptor 0.00174961 0.000693863 0.000693863
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.00132807 0.0000413697 0.0000413697
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.00695217 0.00874694 0.113443
Loa Loa (eye worm) hypothetical protein 0.00220571 0.00139987 0.00139987
Brugia malayi Melatonin receptor type 1A 0.00174961 0.000693863 0.000693863
Schistosoma mansoni single-minded 0.00468707 0.00524078 0.00524078
Brugia malayi gonadotropin-releasing hormone receptor 2 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) tubulin alpha chain 0.0360857 0.0538429 0.0538429
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) hypothetical protein 0.00218866 0.00137348 0.00137348
Echinococcus granulosus neuropeptide Y receptor 0.00174961 0.000693863 0.000693863
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.00695217 0.00874694 0.113443
Onchocerca volvulus 0.00174961 0.000693863 0.000693863
Trichomonas vaginalis tubulin, putative 0.0149106 0.0210658 0.273211
Brugia malayi Serotonin/octopamine receptor family protein 7 0.00174961 0.000693863 0.000693863
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.00165084 0.000540978 0.00164754
Echinococcus multilocularis rhodopsin orphan GPCR 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis tubulin alpha 3 chain 0.0360857 0.0538429 0.0538429
Loa Loa (eye worm) hypothetical protein 0.00255533 0.00194104 0.00194104
Echinococcus multilocularis serotonin receptor 0.00174961 0.000693863 0.000693863
Echinococcus granulosus biogenic amine 5HT receptor 0.00174961 0.000693863 0.000693863
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.00292454 0.00251255 0.00765192
Trypanosoma brucei zeta tubulin, putative 0.0234894 0.034345 0.104597
Leishmania major hypothetical protein, conserved 0.00132807 0.0000413697 0.000125991
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.00132984 0.0000441063 0.000040054
Echinococcus granulosus tm gpcr rhodopsin 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis tubulin alpha 0.0270995 0.0399331 0.0399331
Echinococcus granulosus tubulin subunit TubB 0.0360857 0.0538429 0.0538429
Loa Loa (eye worm) hypothetical protein 0.00165084 0.000540978 0.000540978
Onchocerca volvulus 0.00174961 0.000693863 0.000693863
Toxoplasma gondii beta tubulin 0.0511135 0.0771045 0.23482
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.00782909 0.0101043 0.131047
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.00132807 0.0000413697 0.0000413697
Schistosoma mansoni neuropeptide receptor 0.00174961 0.000693863 0.000693863
Brugia malayi Dopamine receptor protein 1 0.00174961 0.000693863 0.000693863
Schistosoma mansoni BC026374 protein (S09 family) 0.00782909 0.0101043 0.0101043
Echinococcus granulosus single minded 2 0.00442946 0.00484203 0.00484203
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.00210248 0.00124008 0.00124008
Echinococcus multilocularis Dipeptidyl peptidase 9 0.21343 0.328355 0.328355
Onchocerca volvulus 0.00220571 0.00139987 0.00139987
Trichomonas vaginalis conserved hypothetical protein 0.0454669 0.0683641 0.886642
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.00220571 0.00139987 0.0181555
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0238968 0.0349756 0.0349756
Leishmania major beta tubulin 0.0511135 0.0771045 0.23482
Loa Loa (eye worm) sodium-independent organic anion transporter 0.00255533 0.00194104 0.00194104
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis neuropeptide Y receptor 0.00174961 0.000693863 0.000693863
Schistosoma mansoni tubulin subunit beta 0.0511135 0.0771045 0.0771045
Schistosoma mansoni tubulin subunit alpha 0.0360857 0.0538429 0.0538429
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0454669 0.0683641 1
Loa Loa (eye worm) G-protein coupled receptor 0.00174961 0.000693863 0.000693863
Leishmania major alpha tubulin 0.0360857 0.0538429 0.163978
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Echinococcus granulosus acetylcholinesterase 0.0463354 0.0697085 0.0697085
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.00174961 0.000693863 0.000693863
Echinococcus granulosus cGMP dependent protein kinase 1 0.00132807 0.0000413697 0.0000413697
Echinococcus multilocularis tubulin alpha chain 0.0360857 0.0538429 0.0538429
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.00132807 0.0000413697 0.000125991
Plasmodium falciparum peptidase, putative 0.0454669 0.0683641 0.886642
Brugia malayi N-terminal motif family protein 0.00132807 0.0000413697 0.0000413697
Schistosoma mansoni biogenic amine receptor 0.00174961 0.000693863 0.000693863
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0270995 0.0399331 0.121615
Echinococcus granulosus thyrotropin releasing hormone receptor 0.00174961 0.000693863 0.000693863
Schistosoma mansoni voltage-gated potassium channel 0.00306298 0.00272685 0.00272685
Echinococcus multilocularis Tubulin beta 2C chain 0.0511135 0.0771045 0.0771045
Schistosoma mansoni adenoreceptor 0.00174961 0.000693863 0.000693863
Plasmodium vivax tubulin gamma chain, putative 0.0282201 0.0416677 0.540405
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00174961 0.000693863 0.000693863
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.00132807 0.0000413697 0.000125991
Loa Loa (eye worm) tubulin gamma chain 0.0282201 0.0416677 0.0416677
Onchocerca volvulus 0.00174961 0.000693863 0.000693863
Onchocerca volvulus Neuropeptide F receptor homolog 0.00174961 0.000693863 0.000693863
Mycobacterium ulcerans carboxylesterase, LipT 0.00782909 0.0101043 0.147286
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.00220571 0.00139987 0.00426328
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.00132807 0.0000413697 0.0000413697
Trichomonas vaginalis tubulin beta chain, putative 0.0360857 0.0538429 0.698311
Loa Loa (eye worm) tubulin beta chain 0.0121889 0.0168529 0.0168529
Schistosoma mansoni hypothetical protein 0.00174961 0.000693863 0.000693863
Echinococcus granulosus neuropeptide receptor A26 0.00174961 0.000693863 0.000693863
Brugia malayi Carboxylesterase family protein 0.00782909 0.0101043 0.0101043
Schistosoma mansoni neuropeptide receptor 0.00174961 0.000693863 0.000693863
Echinococcus granulosus rhodopsin orphan GPCR 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) hypothetical protein 0.0157247 0.0223259 0.0223259
Schistosoma mansoni growth hormone secretagogue receptor 0.00174961 0.000693863 0.000693863
Leishmania major beta tubulin 0.0511135 0.0771045 0.23482
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0322869 0.0479627 0.0479627
Echinococcus multilocularis tachykinin peptides receptor 99D 0.00174961 0.000693863 0.000693863
Toxoplasma gondii hypothetical protein 0.00565082 0.00673257 0.0205039
Echinococcus multilocularis g protein coupled receptor 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis agrin 0.00165084 0.000540978 0.000540978
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.00132807 0.0000413697 0.0000413697
Onchocerca volvulus 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.00695217 0.00874694 0.00874694
Brugia malayi Tubulin beta-1 chain 0.0511135 0.0771045 0.0771045
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.21343 0.328355 0.328355
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.00174961 0.000693863 0.000693863
Echinococcus granulosus alpha tubulin 0.0360857 0.0538429 0.0538429
Schistosoma mansoni voltage-gated potassium channel 0.00173491 0.000671115 0.000671115
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.00220571 0.00139987 0.0181555
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis carboxylesterase 5A 0.0463354 0.0697085 0.0697085
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.00132807 0.0000413697 0.000536541
Plasmodium vivax DNA topoisomerase II, putative 0.00324888 0.0030146 0.0390976
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00174961 0.000693863 0.000693863
Echinococcus granulosus acylamino acid releasing enzyme 0.0454669 0.0683641 0.0683641
Trypanosoma brucei cAMP binding protein, putative 0.00132807 0.0000413697 0.000125991
Echinococcus multilocularis tubulin alpha chain 0.0360857 0.0538429 0.0538429
Echinococcus granulosus cGMP dependent protein kinase 1 0.00132807 0.0000413697 0.0000413697
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Schistosoma mansoni tubulin subunit beta 0.0511135 0.0771045 0.0771045
Brugia malayi hypothetical protein 0.167963 0.257977 0.257977
Brugia malayi Cyclic-nucleotide gated cation channel 0.00210248 0.00124008 0.00124008
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.21343 0.328355 1
Loa Loa (eye worm) alpha-tubulin 0.0360857 0.0538429 0.0538429
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.00859472 0.0112894 0.146417
Trypanosoma cruzi cAMP binding protein, putative 0.00132807 0.0000413697 0.000125991
Leishmania major DNA topoisomerase ii 0.00292454 0.00251255 0.00765192
Leishmania major hypothetical protein, conserved 0.00132807 0.0000413697 0.000125991
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.00174961 0.000693863 0.000693863
Onchocerca volvulus 0.00255533 0.00194104 0.00194104
Brugia malayi G-protein coupled receptor 0.00174961 0.000693863 0.000693863
Trypanosoma cruzi hypothetical protein, conserved 0.0454669 0.0683641 0.208201
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.00220571 0.00139987 0.00139987
Echinococcus granulosus tubulin alpha 3 chain 0.0360857 0.0538429 0.0538429
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0454669 0.0683641 0.208201
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Trypanosoma cruzi oligopeptidase b 0.0454669 0.0683641 0.208201
Brugia malayi alpha-tubulin 0.0360857 0.0538429 0.0538429
Loa Loa (eye worm) hypothetical protein 0.00782909 0.0101043 0.0101043
Brugia malayi sodium-independent organic anion transporter family protein 0.00255533 0.00194104 0.00194104
Schistosoma mansoni amine GPCR 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis neuropeptide FF receptor 2 0.00174961 0.000693863 0.000693863
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.00132807 0.0000413697 0.000125991
Echinococcus multilocularis tubulin alpha 3 chain 0.0360857 0.0538429 0.0538429
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) hypothetical protein 0.00165084 0.000540978 0.000540978
Trichomonas vaginalis tubulin alpha chain, putative 0.0511135 0.0771045 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.00210248 0.00124008 0.00124008
Brugia malayi Cell division protein ftsZ 0.0107238 0.014585 0.014585
Toxoplasma gondii serine carboxypeptidase s28 protein 0.00220571 0.00139987 0.00426328
Trypanosoma brucei beta tubulin 0.0511135 0.0771045 0.23482
Trypanosoma brucei beta tubulin 0.0511135 0.0771045 0.23482
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.00220571 0.00139987 0.0181555
Trypanosoma brucei tubulin delta chain 0.0189752 0.0273575 0.0833166
Loa Loa (eye worm) hypothetical protein 0.00255533 0.00194104 0.00194104
Schistosoma mansoni peptide (allatostatin)-like receptor 0.00174961 0.000693863 0.000693863
Echinococcus granulosus para nitrobenzyl esterase 0.00782909 0.0101043 0.0101043
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00174961 0.000693863 0.000693863
Onchocerca volvulus 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) hypothetical protein 0.0454669 0.0683641 0.0683641
Onchocerca volvulus 0.00132807 0.0000413697 0.0000413697
Trichomonas vaginalis conserved hypothetical protein 0.0121889 0.0168529 0.218573
Brugia malayi hypothetical protein 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) hypothetical protein 0.00782909 0.0101043 0.0101043
Trichomonas vaginalis tubulin alpha chain, putative 0.0149106 0.0210658 0.273211
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.00220571 0.00139987 0.0181555
Loa Loa (eye worm) hypothetical protein 0.00804105 0.0104324 0.0104324
Schistosoma mansoni neuroligin 3 (S09 family) 0.00782909 0.0101043 0.0101043
Trypanosoma cruzi beta tubulin, putative 0.0511135 0.0771045 0.23482
Loa Loa (eye worm) tubulin alpha chain 0.0360857 0.0538429 0.0538429
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.00132807 0.0000413697 0.0000413697
Loa Loa (eye worm) G-protein coupled receptor 0.00174961 0.000693863 0.000693863
Trypanosoma cruzi hypothetical protein, conserved 0.00132807 0.0000413697 0.000125991
Schistosoma mansoni alpha tubulin 0.0360857 0.0538429 0.0538429
Brugia malayi beta-tubulin, identical 0.0511135 0.0771045 0.0771045
Brugia malayi neuropeptide F receptor 0.00174961 0.000693863 0.000693863
Brugia malayi hypoxia-induced factor 1 0.0145066 0.0204404 0.0204404
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.00220571 0.00139987 0.00139987
Echinococcus multilocularis rhodopsin orphan GPCR 0.00174961 0.000693863 0.000693863
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.00253377 0.00190767 0.00580978
Echinococcus granulosus g-protein coupled receptor 0.00174961 0.000693863 0.000693863
Brugia malayi Egg laying defective protein 4 0.00132807 0.0000413697 0.0000413697
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.00132807 0.0000413697 0.000125991
Leishmania major oligopeptidase b 0.0454669 0.0683641 0.208201
Echinococcus multilocularis peroxisome assembly protein 26 0.0360857 0.0538429 0.0538429
Onchocerca volvulus 0.00782909 0.0101043 0.0101043
Schistosoma mansoni 60S ribosomal protein L21 0.00173491 0.000671115 0.000671115
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Echinococcus granulosus peroxisome assembly protein 26 0.0360857 0.0538429 0.0538429
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Schistosoma mansoni alpha-1 adrenergic receptor 0.00174961 0.000693863 0.000693863
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis allatostatin A receptor 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.00132807 0.0000413697 0.000125991
Echinococcus multilocularis cGMP dependent protein kinase 1 0.00132807 0.0000413697 0.0000413697
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.00695217 0.00874694 0.00874694
Brugia malayi Tubulin alpha-2 chain 0.0360857 0.0538429 0.0538429
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.00210248 0.00124008 0.00124008
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.00220571 0.00139987 0.0181555
Toxoplasma gondii beta-tubulin, putative 0.0511135 0.0771045 0.23482
Onchocerca volvulus DNA topoisomerase 2 homolog 0.002363 0.00164333 0.00164333
Onchocerca volvulus 0.00174961 0.000693863 0.000693863
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.00253377 0.00190767 0.00580978
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.00220571 0.00139987 0.0181555
Loa Loa (eye worm) tubulin beta-1 chain 0.0511135 0.0771045 0.0771045
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.00132807 0.0000413697 0.0000413697
Trypanosoma cruzi cytochrome P450, putative 0.0023876 0.00168142 0.00512073
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.00210248 0.00124008 0.0160831
Loa Loa (eye worm) carboxylesterase 0.00782909 0.0101043 0.0101043
Leishmania major protein kinase A regulatory subunit, putative 0.00132807 0.0000413697 0.000125991
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0121889 0.0168529 0.218573
Schistosoma mansoni amine GPCR 0.00174961 0.000693863 0.000693863
Echinococcus granulosus tm gpcr rhodopsin 0.00174961 0.000693863 0.000693863
Mycobacterium ulcerans cell division protein FtsZ 0.0332103 0.049392 0.722316
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.00695217 0.00874694 0.113443
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.00220571 0.00139987 0.0181555
Trichomonas vaginalis tubulin gamma chain, putative 0.0511135 0.0771045 1
Toxoplasma gondii DNA topoisomerase 2, putative 0.00324888 0.0030146 0.0091809
Loa Loa (eye worm) hypothetical protein 0.00132807 0.0000413697 0.0000413697
Brugia malayi Serotonin receptor 0.00174961 0.000693863 0.000693863
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.21343 0.328355 1
Loa Loa (eye worm) hypothetical protein 0.00220571 0.00139987 0.00139987
Giardia lamblia Serine peptidase, putative 0.00220571 0.00139987 0.0181555
Echinococcus multilocularis tubulin alpha chain 0.0360857 0.0538429 0.0538429
Schistosoma mansoni tubulin subunit epsilon 0.028202 0.0416396 0.0416396
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.00782909 0.0101043 0.147286
Echinococcus granulosus hypothetical protein 0.00174961 0.000693863 0.000693863
Schistosoma mansoni tubulin subunit beta 0.0511135 0.0771045 0.0771045
Schistosoma mansoni gliotactin 0.00782909 0.0101043 0.0101043
Onchocerca volvulus 0.00174961 0.000693863 0.000693863
Echinococcus granulosus neuropeptide receptor 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.00936912 0.0124882 0.0124882
Loa Loa (eye worm) neuropeptide F receptor 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.00132807 0.0000413697 0.0000413697
Trypanosoma cruzi protein kinase A regulatory subunit 0.00132807 0.0000413697 0.000125991
Echinococcus granulosus G protein coupled receptor 139 0.00174961 0.000693863 0.000693863
Echinococcus granulosus biogenic amine 5HT receptor 0.00174961 0.000693863 0.000693863
Giardia lamblia Rab geranylgeranyltransferase 0.00695217 0.00874694 0.113443
Leishmania major beta tubulin 0.0511135 0.0771045 0.23482
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00174961 0.000693863 0.000693863
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0238968 0.0349756 0.453613
Brugia malayi Serotonin receptor 0.00174961 0.000693863 0.000693863
Onchocerca volvulus Putative organic anion transporter 0.00255533 0.00194104 0.00194104
Schistosoma mansoni tubulin subunit beta 0.0511135 0.0771045 0.0771045
Echinococcus granulosus rhodopsin orphan GPCR 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis alpha 1A adrenergic receptor 0.00174961 0.000693863 0.000693863
Trypanosoma cruzi cAMP response protein 1 0.00132807 0.0000413697 0.000125991
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.00220571 0.00139987 0.00426328
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.00220571 0.00139987 0.0181555
Onchocerca volvulus 0.00174961 0.000693863 0.000693863
Brugia malayi hypothetical protein 0.00174961 0.000693863 0.000693863
Echinococcus granulosus neuropeptide Y receptor 0.00174961 0.000693863 0.000693863
Brugia malayi prolyl oligopeptidase family protein 0.647336 1 1
Loa Loa (eye worm) hypothetical protein 0.00218866 0.00137348 0.00137348
Onchocerca volvulus 0.00782909 0.0101043 0.0101043
Onchocerca volvulus Prolyl endopeptidase homolog 0.0454669 0.0683641 0.0683641
Trichomonas vaginalis tubulin epsilon chain, putative 0.0511135 0.0771045 1
Treponema pallidum cell division protein FtsZ 0.0332103 0.049392 1
Brugia malayi hypothetical protein 0.00782909 0.0101043 0.0101043
Echinococcus multilocularis Tubulin beta 2C chain 0.0511135 0.0771045 0.0771045
Echinococcus granulosus DNA topoisomerase 2 alpha 0.00324888 0.0030146 0.0030146
Trypanosoma brucei cAMP response protein 1, putative 0.00132807 0.0000413697 0.000125991
Trichomonas vaginalis tubulin epsilon chain, putative 0.0121889 0.0168529 0.218573
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.00220571 0.00139987 0.0181555
Brugia malayi Carboxylesterase family protein 0.0463354 0.0697085 0.0697085
Echinococcus multilocularis rhodopsin orphan GPCR 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) hypothetical protein 0.00306298 0.00272685 0.00272685
Loa Loa (eye worm) hypothetical protein 0.00156605 0.000409728 0.000409728
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Entamoeba histolytica tubulin gamma chain 0.0282201 0.0416677 0.540405
Leishmania major cytochrome p450-like protein 0.0023876 0.00168142 0.00512073
Echinococcus granulosus tubulin alpha chain 0.0360857 0.0538429 0.0538429
Mycobacterium tuberculosis Probable peptidase 0.0454669 0.0683641 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.00174961 0.000693863 0.000693863
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.00220571 0.00139987 0.0181555
Trichomonas vaginalis conserved hypothetical protein 0.00132807 0.0000413697 0.000536541
Echinococcus granulosus neuropeptides capa receptor 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis rhodopsin orphan GPCR 0.00174961 0.000693863 0.000693863
Onchocerca volvulus 0.00782909 0.0101043 0.0101043
Trypanosoma brucei DNA topoisomerase ii 0.00253377 0.00190767 0.00580978
Echinococcus granulosus tubulin alpha 3 chain 0.0360857 0.0538429 0.0538429
Echinococcus granulosus rhodopsin orphan GPCR 0.00174961 0.000693863 0.000693863
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.00165084 0.000540978 0.000540978
Brugia malayi Tubulin gamma chain 0.0282201 0.0416677 0.0416677
Brugia malayi hypothetical protein 0.00255533 0.00194104 0.00194104
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00174961 0.000693863 0.000693863
Schistosoma mansoni organic anion transporter 0.00255533 0.00194104 0.00194104
Brugia malayi Tubulin alpha-2 chain 0.0360857 0.0538429 0.0538429
Loa Loa (eye worm) hypothetical protein 0.0454669 0.0683641 0.0683641
Plasmodium falciparum tubulin beta chain 0.0511135 0.0771045 1
Brugia malayi G protein-coupled receptor F59B2.13 0.00174961 0.000693863 0.000693863
Giardia lamblia Delta tubulin 0.0121889 0.0168529 0.218573
Loa Loa (eye worm) follicle stimulating hormone receptor 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) hypothetical protein 0.00255533 0.00194104 0.00194104
Leishmania major regulatory subunit of protein kinase a-like protein 0.00132807 0.0000413697 0.000125991
Loa Loa (eye worm) tubulin alpha 2 0.0238968 0.0349756 0.0349756
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.00306298 0.00272685 0.00272685
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0454669 0.0683641 1
Plasmodium falciparum tubulin gamma chain 0.0282201 0.0416677 0.540405
Echinococcus granulosus tm gpcr rhodopsin 0.00174961 0.000693863 0.000693863
Brugia malayi hypothetical protein 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) hypothetical protein 0.00132807 0.0000413697 0.0000413697
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.00132807 0.0000413697 0.000536541
Leishmania major alpha tubulin 0.0360857 0.0538429 0.163978
Echinococcus multilocularis expressed conserved protein 0.00132807 0.0000413697 0.0000413697
Trypanosoma brucei protein kinase A regulatory subunit 0.00132807 0.0000413697 0.000125991
Echinococcus granulosus neuropeptides capa receptor 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) TOPoisomerase family member 0.00324888 0.0030146 0.0030146
Loa Loa (eye worm) hypothetical protein 0.00695217 0.00874694 0.00874694
Echinococcus granulosus peptide allatostatin:somatostatin 0.00174961 0.000693863 0.000693863
Entamoeba histolytica tubulin alpha-1 chain 0.0360857 0.0538429 0.698311
Leishmania major beta tubulin 0.0511135 0.0771045 0.23482
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis rhodopsin orphan GPCR 0.00174961 0.000693863 0.000693863
Onchocerca volvulus 0.00174961 0.000693863 0.000693863
Trichomonas vaginalis tubulin, putative 0.0149106 0.0210658 0.273211
Trypanosoma brucei alpha tubulin, putative 0.0149106 0.0210658 0.0641554
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.00695217 0.00874694 0.00874694
Plasmodium falciparum cGMP-dependent protein kinase 0.00132807 0.0000413697 0.000536541
Leishmania major alpha tubulin 0.0360857 0.0538429 0.163978
Brugia malayi SPARC precursor 0.00165084 0.000540978 0.000540978
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0454669 0.0683641 0.208201
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Plasmodium vivax tubulin alpha chain, putative 0.0360857 0.0538429 0.698311
Plasmodium falciparum alpha tubulin 2 0.0360857 0.0538429 0.698311
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.00132807 0.0000413697 0.0000413697
Schistosoma mansoni tubulin subunit alpha 0.0360857 0.0538429 0.0538429
Plasmodium falciparum alpha tubulin 1 0.0360857 0.0538429 0.698311
Echinococcus granulosus organic anion transporting polypeptide 30B 0.00255533 0.00194104 0.00194104
Schistosoma mansoni neuropeptide receptor 0.00174961 0.000693863 0.000693863
Leishmania major hypothetical protein, conserved 0.00132807 0.0000413697 0.000125991
Trypanosoma cruzi MFS transporter, putative 0.00255533 0.00194104 0.00591141
Echinococcus granulosus Tubulin beta 2C chain 0.0511135 0.0771045 0.0771045
Trypanosoma brucei alpha tubulin 0.0360857 0.0538429 0.163978
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.00174961 0.000693863 0.000693863
Trichomonas vaginalis spcc417.12 protein, putative 0.00782909 0.0101043 0.131047
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0454669 0.0683641 0.208201
Echinococcus multilocularis beta tubulin 0.0511135 0.0771045 0.0771045
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0454669 0.0683641 0.0683641
Leishmania major beta tubulin 0.0511135 0.0771045 0.23482
Loa Loa (eye worm) hypothetical protein 0.0454669 0.0683641 0.0683641
Echinococcus multilocularis Tubulin alpha 1 chain 0.0360857 0.0538429 0.0538429
Leishmania major beta tubulin 0.0511135 0.0771045 0.23482
Brugia malayi Tubulin alpha chain 0.0121889 0.0168529 0.0168529
Echinococcus granulosus tubulin epsilon chain 0.028202 0.0416396 0.0416396
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.00859472 0.0112894 0.146417
Trichomonas vaginalis tubulin alpha chain, putative 0.0270995 0.0399331 0.517909
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.00936912 0.0124882 0.0124882
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Leishmania major beta tubulin 0.0511135 0.0771045 0.23482
Leishmania major delta tubulin, putative 0.0189752 0.0273575 0.0833166
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.00132807 0.0000413697 0.0000413697
Giardia lamblia Alanyl dipeptidyl peptidase 0.0454669 0.0683641 0.886642
Entamoeba histolytica hypothetical protein, conserved 0.0454669 0.0683641 0.886642
Onchocerca volvulus 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis rhodopsin orphan GPCR 0.00174961 0.000693863 0.000693863
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00174961 0.000693863 0.000693863
Leishmania major gamma-tubulin 0.0282201 0.0416677 0.126898
Loa Loa (eye worm) hypothetical protein 0.00255533 0.00194104 0.00194104
Onchocerca volvulus 0.00165084 0.000540978 0.000540978
Schistosoma mansoni organic anion transporter 0.00255533 0.00194104 0.00194104
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00174961 0.000693863 0.000693863
Trichomonas vaginalis tubulin beta chain, putative 0.0360857 0.0538429 0.698311
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.00220571 0.00139987 0.0181555
Mycobacterium ulcerans short chain dehydrogenase 0.0163704 0.0233254 0.340795
Loa Loa (eye worm) hypothetical protein 0.00220571 0.00139987 0.00139987
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.00132807 0.0000413697 0.000536541
Echinococcus granulosus hyperpolarization activated cyclic 0.00210248 0.00124008 0.00124008
Echinococcus granulosus rhodopsin orphan GPCR 0.00174961 0.000693863 0.000693863
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0211752 0.0307628 0.398975
Giardia lamblia Beta tubulin 0.0511135 0.0771045 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.00174961 0.000693863 0.000693863
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00174961 0.000693863 0.000693863
Brugia malayi Serine protease Z688.6 precursor 0.00220571 0.00139987 0.00139987
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0149106 0.0210658 0.273211
Loa Loa (eye worm) hypothetical protein 0.00255533 0.00194104 0.00194104
Toxoplasma gondii alpha tubulin TUBA1 0.0360857 0.0538429 0.163978
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Toxoplasma gondii prolyl endopeptidase 0.0454669 0.0683641 0.208201
Loa Loa (eye worm) hypothetical protein 0.00255533 0.00194104 0.00194104
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0454669 0.0683641 0.886642
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.00165084 0.000540978 0.000540978
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.002363 0.00164333 0.00164333
Onchocerca volvulus Putative organic anion transporter 0.00255533 0.00194104 0.00194104
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.00165084 0.000540978 0.00164754
Brugia malayi larval opioid receptor 0.00174961 0.000693863 0.000693863
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0322869 0.0479627 0.0479627
Brugia malayi RE15519p 0.00174961 0.000693863 0.000693863
Onchocerca volvulus 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) hypothetical protein 0.00782909 0.0101043 0.0101043
Brugia malayi putative neuropeptide receptor NPR1 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) tubulin beta-2A chain 0.0511135 0.0771045 0.0771045
Echinococcus multilocularis fmrfamide receptor 0.00174961 0.000693863 0.000693863
Echinococcus granulosus somatostatin receptor 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis hyperpolarization activated cyclic 0.00210248 0.00124008 0.00124008
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.00174961 0.000693863 0.000693863
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.00220571 0.00139987 0.0181555
Brugia malayi G-protein coupled receptor 0.00174961 0.000693863 0.000693863
Trypanosoma brucei oligopeptidase b 0.0454669 0.0683641 0.208201
Mycobacterium ulcerans putative regulatory protein 0.00346896 0.00335526 0.0485035
Plasmodium vivax prenyltransferase alpha subunit, putative 0.00695217 0.00874694 0.113443
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.00255533 0.00194104 0.00194104
Leishmania major protein kinase, putative 0.00254618 0.00192689 0.00586829
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00174961 0.000693863 0.000693863
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.00174961 0.000693863 0.000693863
Entamoeba histolytica tubulin family protein 0.0511135 0.0771045 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0360857 0.0538429 0.0538429
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.00132807 0.0000413697 0.0000413697
Echinococcus granulosus neuropeptide FF receptor 2 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) alpha-tubulin 0.0360857 0.0538429 0.0538429
Loa Loa (eye worm) hypothetical protein 0.0238968 0.0349756 0.0349756
Brugia malayi GnHR receptor homolog 0.00174961 0.000693863 0.000693863
Brugia malayi PAS domain containing protein 0.00468707 0.00524078 0.00524078
Echinococcus granulosus tubulin alpha chain 0.0360857 0.0538429 0.0538429
Schistosoma mansoni myosin xvIII 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis acylamino acid releasing enzyme 0.0454669 0.0683641 0.0683641
Leishmania major alpha tubulin 0.0360857 0.0538429 0.163978
Trichomonas vaginalis conserved hypothetical protein 0.00220571 0.00139987 0.0181555
Onchocerca volvulus 0.00132807 0.0000413697 0.0000413697
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.00165084 0.000540978 0.00164754
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Leishmania major alpha tubulin 0.0360857 0.0538429 0.163978
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.00132807 0.0000413697 0.0000413697
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Brugia malayi hypothetical protein 0.0157247 0.0223259 0.0223259
Onchocerca volvulus 0.00255533 0.00194104 0.00194104
Echinococcus multilocularis BC026374 protein (S09 family) 0.00782909 0.0101043 0.0101043
Echinococcus multilocularis tubulin subunit TubB 0.0360857 0.0538429 0.0538429
Trichomonas vaginalis tubulin epsilon chain, putative 0.0511135 0.0771045 1
Echinococcus granulosus agrin 0.00165084 0.000540978 0.000540978
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.00132807 0.0000413697 0.000536541
Echinococcus granulosus 7TM GPCR rhodopsin 0.00174961 0.000693863 0.000693863
Onchocerca volvulus 0.00174961 0.000693863 0.000693863
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023876 0.00168142 0.0240045
Toxoplasma gondii transporter, major facilitator family protein 0.00255533 0.00194104 0.00591141
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis g protein coupled receptor 0.00174961 0.000693863 0.000693863
Trypanosoma cruzi zeta tubulin, putative 0.0234894 0.034345 0.104597
Trypanosoma brucei prolyl oligopeptidase, putative 0.0454669 0.0683641 0.208201
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.21343 0.328355 1
Entamoeba histolytica DNA topoisomerase II, putative 0.00324888 0.0030146 0.0390976
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0454669 0.0683641 0.886642
Echinococcus multilocularis g protein coupled receptor 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis tubulin subunit beta 0.0511135 0.0771045 0.0771045
Echinococcus granulosus rhodopsin orphan GPCR 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis Solute carrier organic anion transporter family 0.00255533 0.00194104 0.00194104
Loa Loa (eye worm) TYRA-2 protein 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis tubulin delta chain 0.0121889 0.0168529 0.0168529
Schistosoma mansoni serine/threonine protein kinase 0.00132807 0.0000413697 0.0000413697
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Onchocerca volvulus 0.00174961 0.000693863 0.000693863
Trypanosoma cruzi tubulin delta chain 0.0189752 0.0273575 0.0833166
Schistosoma mansoni voltage-gated potassium channel 0.0103296 0.0139749 0.0139749
Schistosoma mansoni acetylcholinesterase 0.00782909 0.0101043 0.0101043
Trichomonas vaginalis tubulin beta chain, putative 0.0360857 0.0538429 0.698311
Loa Loa (eye worm) BEN-1 protein 0.0511135 0.0771045 0.0771045
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.00220571 0.00139987 0.0181555
Trypanosoma cruzi tubulin gamma chain 0.0282201 0.0416677 0.126898
Plasmodium vivax hypothetical protein, conserved 0.0454669 0.0683641 0.886642
Plasmodium falciparum tubulin epsilon chain, putative 0.028202 0.0416396 0.540042
Schistosoma mansoni tubulin subunit delta 0.0121889 0.0168529 0.0168529
Echinococcus multilocularis tubulin alpha chain 0.0360857 0.0538429 0.0538429
Brugia malayi AKH receptor 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) hypothetical protein 0.00145099 0.000231634 0.000231634
Echinococcus multilocularis orexin receptor type 2 0.00174961 0.000693863 0.000693863
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0463354 0.0697085 0.0697085
Loa Loa (eye worm) tubulin alpha 2 0.00898623 0.0118955 0.0118955
Echinococcus granulosus Dipeptidyl peptidase 9 0.21343 0.328355 0.328355
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.00210248 0.00124008 0.00124008
Trypanosoma cruzi prolyl endopeptidase 0.0454669 0.0683641 0.208201
Toxoplasma gondii hypothetical protein 0.0454669 0.0683641 0.208201
Echinococcus granulosus tubulin delta chain 0.0121889 0.0168529 0.0168529
Brugia malayi Serine carboxypeptidase S28 family protein 0.00220571 0.00139987 0.00139987
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00174961 0.000693863 0.000693863
Brugia malayi Tubulin beta chain 0.0149106 0.0210658 0.0210658
Brugia malayi sodium-independent organic anion transporter family protein 0.00255533 0.00194104 0.00194104
Echinococcus granulosus tubulin alpha chain 0.0360857 0.0538429 0.0538429
Trichomonas vaginalis tubulin alpha chain, putative 0.0149106 0.0210658 0.273211
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.00324888 0.0030146 0.0030146
Schistosoma mansoni biogenic amine receptor 0.00174961 0.000693863 0.000693863
Brugia malayi hypothetical protein 0.00174961 0.000693863 0.000693863
Echinococcus multilocularis prolyl endopeptidase 0.0454669 0.0683641 0.0683641
Echinococcus multilocularis acetylcholinesterase 0.0463354 0.0697085 0.0697085
Echinococcus multilocularis beta tubulin 0.0511135 0.0771045 0.0771045
Echinococcus multilocularis hypothetical protein 0.0360857 0.0538429 0.0538429
Schistosoma mansoni neuropeptide receptor 0.00174961 0.000693863 0.000693863
Echinococcus granulosus Tubulin beta 2C chain 0.0511135 0.0771045 0.0771045
Echinococcus granulosus family S9 non peptidase ue S09 family 0.00782909 0.0101043 0.0101043
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.00132807 0.0000413697 0.0000413697
Mycobacterium tuberculosis Cell division protein FtsZ 0.0332103 0.049392 0.722316
Trichomonas vaginalis tubulin beta chain, putative 0.0360857 0.0538429 0.698311
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.00132807 0.0000413697 0.0000413697
Trypanosoma brucei epsilon tubulin 0.028202 0.0416396 0.126813
Echinococcus multilocularis tubulin epsilon chain 0.028202 0.0416396 0.0416396
Schistosoma mansoni serine/threonine protein kinase 0.00132807 0.0000413697 0.0000413697
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Echinococcus granulosus Tubulin beta 2C chain 0.0511135 0.0771045 0.0771045
Schistosoma mansoni follistatin 0.00165084 0.000540978 0.000540978
Schistosoma mansoni DNA topoisomerase II 0.00324888 0.0030146 0.0030146
Trypanosoma brucei Flagellar Member 6 0.00132807 0.0000413697 0.000125991
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.00132807 0.0000413697 0.000125991
Schistosoma mansoni opsin-like receptor 0.00174961 0.000693863 0.000693863
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.00210248 0.00124008 0.00124008
Echinococcus granulosus neuropeptide s receptor 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) CYP4Cod1 0.0023876 0.00168142 0.00168142
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.00220571 0.00139987 0.0181555
Trichomonas vaginalis tubulin beta chain, putative 0.0511135 0.0771045 1
Giardia lamblia DNA topoisomerase II 0.00310654 0.00279428 0.0362401
Echinococcus granulosus cGMP dependent protein kinase 0.00132807 0.0000413697 0.0000413697
Brugia malayi ORL1-like opioid receptor 0.00174961 0.000693863 0.000693863
Echinococcus granulosus sex peptide receptor 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) hypothetical protein 0.00782909 0.0101043 0.0101043
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Brugia malayi prolyl oligopeptidase family protein 0.0454669 0.0683641 0.0683641
Schistosoma mansoni neuropeptide F-like receptor 0.00174961 0.000693863 0.000693863
Trichomonas vaginalis conserved hypothetical protein 0.0121889 0.0168529 0.218573
Loa Loa (eye worm) acetylcholinesterase 1 0.0463354 0.0697085 0.0697085
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0322869 0.0479627 0.0479627
Echinococcus multilocularis voltage gated potassium channel 0.00306298 0.00272685 0.00272685
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.00132807 0.0000413697 0.0000413697
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.00132807 0.0000413697 0.000125991
Onchocerca volvulus 0.00174961 0.000693863 0.000693863
Onchocerca volvulus 0.00782909 0.0101043 0.0101043
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.00936912 0.0124882 0.0124882
Loa Loa (eye worm) hypothetical protein 0.00255533 0.00194104 0.00194104
Echinococcus granulosus tubulin alpha chain 0.0360857 0.0538429 0.0538429
Trypanosoma brucei epsilon tubulin 0.028202 0.0416396 0.126813
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Toxoplasma gondii alpha-tubulin I, putative 0.0360857 0.0538429 0.163978
Brugia malayi Dopamine receptor protein 2 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.00165084 0.000540978 0.000540978
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.00132807 0.0000413697 0.000536541
Schistosoma mansoni alpha tubulin 0.0360857 0.0538429 0.0538429
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) hypothetical protein 0.00165084 0.000540978 0.000540978
Brugia malayi hypothetical protein 0.00174961 0.000693863 0.000693863
Leishmania major beta tubulin 0.0511135 0.0771045 0.23482
Schistosoma mansoni similar to Protein C20orf152 homolog 0.00132807 0.0000413697 0.0000413697
Echinococcus granulosus tubulin alpha chain 0.0360857 0.0538429 0.0538429
Loa Loa (eye worm) tubulin beta chain 0.0511135 0.0771045 0.0771045
Echinococcus granulosus voltage gated potassium channel 0.00306298 0.00272685 0.00272685
Echinococcus multilocularis acetylcholinesterase 0.0463354 0.0697085 0.0697085
Echinococcus multilocularis para nitrobenzyl esterase 0.00782909 0.0101043 0.0101043
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.00210248 0.00124008 0.00124008
Trypanosoma cruzi oligopeptidase b 0.0454669 0.0683641 0.208201
Echinococcus multilocularis neuropeptides capa receptor 0.00174961 0.000693863 0.000693863
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.00782909 0.0101043 0.147286
Echinococcus multilocularis neuropeptide receptor 0.00174961 0.000693863 0.000693863
Echinococcus granulosus hyperpolarization activated cyclic 0.00210248 0.00124008 0.00124008
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.00132807 0.0000413697 0.000536541
Leishmania major alpha tubulin 0.0360857 0.0538429 0.163978
Echinococcus granulosus g protein coupled receptor 0.00174961 0.000693863 0.000693863
Plasmodium vivax tubulin beta chain, putative 0.0511135 0.0771045 1
Echinococcus multilocularis neuropeptide receptor A26 0.00174961 0.000693863 0.000693863
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00174961 0.000693863 0.000693863
Brugia malayi neuropeptide F receptor 0.00174961 0.000693863 0.000693863
Echinococcus granulosus tubulin alpha 0.0270995 0.0399331 0.0399331
Loa Loa (eye worm) hypothetical protein 0.00210248 0.00124008 0.00124008
Echinococcus multilocularis hyperpolarization activated cyclic 0.00210248 0.00124008 0.00124008
Echinococcus multilocularis biogenic amine (5HT) receptor 0.00174961 0.000693863 0.000693863
Trypanosoma brucei beta tubulin 0.0270995 0.0399331 0.121615
Echinococcus granulosus rhodopsin orphan GPCR 0.00174961 0.000693863 0.000693863
Echinococcus granulosus orexin receptor type 2 0.00174961 0.000693863 0.000693863
Echinococcus granulosus Tubulin beta 2C chain 0.0511135 0.0771045 0.0771045
Echinococcus multilocularis neuroligin 0.00782909 0.0101043 0.0101043
Trypanosoma cruzi tubulin delta chain 0.0189752 0.0273575 0.0833166
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.647336 1 1
Echinococcus granulosus beta tubulin 0.0511135 0.0771045 0.0771045
Schistosoma mansoni alpha tubulin 0.0360857 0.0538429 0.0538429
Schistosoma mansoni tubulin subunit alpha 0.0360857 0.0538429 0.0538429
Echinococcus multilocularis serotonin receptor 0.00174961 0.000693863 0.000693863
Trichomonas vaginalis conserved hypothetical protein 0.00220571 0.00139987 0.0181555
Mycobacterium tuberculosis Probable oxidoreductase 0.0163704 0.0233254 0.340795
Chlamydia trachomatis DNA gyrase subunit B 0.00177533 0.000733682 1
Onchocerca volvulus 0.00782909 0.0101043 0.0101043
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.00136045 0.0000914771 0.0723769
Trypanosoma cruzi alpha tubulin, putative 0.0360857 0.0538429 0.163978
Trichomonas vaginalis tubulin, putative 0.0511135 0.0771045 1
Giardia lamblia Gamma tubulin 0.0282201 0.0416677 0.540405
Schistosoma mansoni amine GPCR 0.00174961 0.000693863 0.000693863
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.00132807 0.0000413697 0.0000413697
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.00174961 0.000693863 0.000693863
Brugia malayi Serine protease Z688.6 precursor 0.00220571 0.00139987 0.00139987
Trypanosoma cruzi Flagellar Member 6 0.00132807 0.0000413697 0.000125991
Echinococcus granulosus neuropeptide receptor 0.00174961 0.000693863 0.000693863
Giardia lamblia Alanyl dipeptidyl peptidase 0.0454669 0.0683641 0.886642
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.00165084 0.000540978 0.000540978
Brugia malayi hypothetical protein 0.00174961 0.000693863 0.000693863
Brugia malayi hypothetical protein 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) hypoxia-induced factor 1 0.0145066 0.0204404 0.0204404
Echinococcus granulosus BC026374 protein S09 family 0.00782909 0.0101043 0.0101043
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.00782909 0.0101043 0.0101043
Trichomonas vaginalis tubulin epsilon chain, putative 0.0360857 0.0538429 0.698311
Echinococcus multilocularis G protein coupled receptor 139 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.00132807 0.0000413697 0.0000413697
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0454669 0.0683641 0.886642
Entamoeba histolytica prolyl oligopeptidase family protein 0.0454669 0.0683641 0.886642
Trypanosoma cruzi DNA topoisomerase II, putative 0.00292454 0.00251255 0.00765192
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.00132807 0.0000413697 0.000125991
Onchocerca volvulus 0.0149106 0.0210658 0.0210658
Echinococcus granulosus acetylcholinesterase 0.0463354 0.0697085 0.0697085
Leishmania major alpha tubulin 0.0360857 0.0538429 0.163978
Echinococcus multilocularis cGMP dependent protein kinase 1 0.00132807 0.0000413697 0.0000413697
Trypanosoma brucei zeta tubulin 0.0234894 0.034345 0.104597
Echinococcus granulosus rhodopsin orphan GPCR 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Brugia malayi Tubulin beta chain 0.0121889 0.0168529 0.0168529
Schistosoma mansoni hypothetical protein 0.00132807 0.0000413697 0.0000413697
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.00132807 0.0000413697 0.0000413697
Echinococcus granulosus tubulin beta 4A class IVa 0.0511135 0.0771045 0.0771045
Trichomonas vaginalis tubulin beta chain, putative 0.0360857 0.0538429 0.698311
Echinococcus multilocularis neuropeptide receptor 0.00174961 0.000693863 0.000693863
Trichomonas vaginalis DNA topoisomerase II, putative 0.00324888 0.0030146 0.0390976
Trypanosoma brucei prolyl endopeptidase 0.0454669 0.0683641 0.208201
Leishmania major cyclic nucleotide-binding protein-like protein 0.00132807 0.0000413697 0.000125991
Brugia malayi sulfakinin receptor protein 0.00174961 0.000693863 0.000693863
Brugia malayi prolyl oligopeptidase family protein 0.0454669 0.0683641 0.0683641
Trichomonas vaginalis tubulin beta chain, putative 0.0360857 0.0538429 0.698311
Echinococcus multilocularis follistatin 0.00165084 0.000540978 0.000540978
Loa Loa (eye worm) hypothetical protein 0.00174961 0.000693863 0.000693863
Schistosoma mansoni hypothetical protein 0.00174961 0.000693863 0.000693863
Trichomonas vaginalis tubulin, putative 0.0133095 0.0185875 0.241069
Echinococcus multilocularis neuropeptides capa receptor 0.00174961 0.000693863 0.000693863
Loa Loa (eye worm) hypothetical protein 0.0418661 0.0627904 0.0627904
Echinococcus granulosus g protein coupled receptor 0.00174961 0.000693863 0.000693863
Echinococcus granulosus dro:myosuppressin receptor 0.00174961 0.000693863 0.000693863
Schistosoma mansoni hypothetical protein 0.00174961 0.000693863 0.000693863
Onchocerca volvulus 0.00174961 0.000693863 0.000693863
Brugia malayi hypothetical protein 0.00174961 0.000693863 0.000693863
Trichomonas vaginalis tubulin gamma chain, putative 0.028202 0.0416396 0.540042
Echinococcus granulosus cyclic nucleotide gated cation channel 0.00210248 0.00124008 0.00124008
Loa Loa (eye worm) agrin synaptic family protein 0.00165084 0.000540978 0.000540978

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antiplasmodial activity against GFP-expressing liver stage Plasmodium berghei sporozoites infected in human Huh-7 cells at 5 uM by fluorescence activated cell sorting based method ChEMBL. 21207937
Activity (functional) = 10.8 % Antimalarial activity as reduced parasitaemia against Plasmodium berghei yoelii infected Swiss albino mice (Mus musculus) at 50 mg/kg/day peroral dose for 4 days ChEMBL. 9249972
Activity (functional) = 15.6 % Antimalarial activity as reduced parasitaemia against Plasmodium berghei infected Swiss albino mice (Mus musculus) at 50 mg/kg/day peroral dose for 4 days ChEMBL. 9249972
Activity (binding) = 4.53 umol/min/mg Activity of recombinant human NQO1 assessed as specific activity ChEMBL. 17643990
Body weight (functional) = 193 g In vitro effect of drug administration on Body weight in Fructose fed STZ-treated rats,pre dose (Treatment group - Fructose/STZ ) ChEMBL. 9526563
Body weight (functional) = 201 g In vitro effect of drug administration on Body weight in Fructose fed STZ-treated rats,pre dose ((Treatment group - Fructose/STZ + cryptoline HCl, 30 mg/kg) ChEMBL. 9526563
Body weight (functional) = 207 g In vitro effect of drug administration on Body weight in Fructose fed STZ-treated rats,pre dose (Treatment group - Chow) ChEMBL. 9526563
Body weight (functional) = 211 g In vitro effect of drug administration on Body weight in Fructose fed STZ-treated rats,after 24 hr (Treatment group - Fructose/STZ ) ChEMBL. 9526563
Body weight (functional) = 223 g In vitro effect of drug administration on Body weight in Fructose fed STZ-treated rats,after 24 hr (Treatment group - Fructose/STZ + cryptoline HCl, 30 mg/kg) ChEMBL. 9526563
Body weight (functional) = 244 g In vitro effect of drug administration on Body weight in Fructose fed STZ-treated rats,after 24 hr (Treatment group - Chow) ChEMBL. 9526563
Change (functional) = -43.1 % Change in plasma glucose levels measured in genetically altered obese diabetic mice(db/db) at 100 mg/kg at 24 h postdose ChEMBL. 9667966
Change (functional) = -43.1 % Change in plasma glucose levels measured in genetically altered obese diabetic mice(db/db) at 100 mg/kg at 24 h postdose ChEMBL. 9667966
Change (functional) = -16.4 % Change in plasma glucose levels measured in genetically altered obese diabetic mice(db/db) at 100 mg/kg at 3 h postdose ChEMBL. 9667966
Change (functional) = -16.4 % Change in plasma glucose levels measured in genetically altered obese diabetic mice(db/db) at 100 mg/kg at 3 h postdose ChEMBL. 9667966
Change of predose (functional) = -43.1 % Compound was evaluated in vitro for its ability to stimulate glucose transport in 3T3-L1 adipocytes ,given at 100 mg/kg in mouse,after 24 hr ChEMBL. 9526563
Change of predose (functional) = -43.1 % Compound was evaluated in vitro for its ability to stimulate glucose transport in 3T3-L1 adipocytes ,given at 100 mg/kg in mouse,after 24 hr ChEMBL. 9526563
Change of predose (functional) = -16.4 % Compound was evaluated in vitro for its ability to stimulate glucose transport in 3T3-L1 adipocytes ,given at 100 mg/kg in mouse,after 3 hr ChEMBL. 9526563
Change of predose (functional) = -16.4 % Compound was evaluated in vitro for its ability to stimulate glucose transport in 3T3-L1 adipocytes ,given at 100 mg/kg in mouse,after 3 hr ChEMBL. 9526563
Change of predose (functional) = 170.7 % Effect of the compound when given at 30 mg/kg in (C57BL/ks)mouse,after day 3 ChEMBL. 9526563
Change of predose (functional) = 170.7 % Effect of the compound when given at 30 mg/kg in (C57BL/ks)mouse,after day 3 ChEMBL. 9526563
Change of predose (functional) = 184.5 % Effect of the compound when given at 30 mg/kg in (C57BL/ks)mouse,Predose ChEMBL. 9526563
Change of predose (functional) = 184.5 % Effect of the compound when given at 30 mg/kg in (C57BL/ks)mouse,Predose ChEMBL. 9526563
Change of predose (functional) = 358 % Effect of the compound when given at 30 mg/kg in (db/db)mice,3 days postdose ChEMBL. 9526563
Change of predose (functional) = 358 % Effect of the compound when given at 30 mg/kg in (db/db)mice,3 days postdose ChEMBL. 9526563
Food intake (functional) = 18 g day-1 In vitro effect of drug administration on food consumption in Fructose fed STZ-treated rats (Treatment group - Fructose/STZ + cryptoline HCl, 30 mg/kg) ChEMBL. 9526563
Food intake (functional) = 22 g day-1 In vitro effect of drug administration on food consumption in Fructose fed STZ-treated rats (Treatment group - Chow) ChEMBL. 9526563
Food intake (functional) = 25 g day-1 In vitro effect of drug administration on food consumption in Fructose fed STZ-treated rats (Treatment group - Fructose/STZ ) ChEMBL. 9526563
Food intake (functional) = 0.9 g mouse-1 day-1 Food intake in db/db Mice expressed as gram/mouse/day and the observed after 48 hr. ChEMBL. 9526563
Food intake (functional) = 0.9 g mouse-1 day-1 Food intake measured in genetically altered obese diabetic mice(db/db) at 100 mg/kg dose ChEMBL. 9667966
Food intake (functional) = 0.9 g mouse-1 day-1 Food intake in db/db Mice expressed as gram/mouse/day and the observed after 48 hr. ChEMBL. 9526563
Food intake (functional) = 0.9 g mouse-1 day-1 Food intake measured in genetically altered obese diabetic mice(db/db) at 100 mg/kg dose ChEMBL. 9667966
Food intake (functional) = 2.3 g mouse-1 day-1 Food intake in C57BL/ks Mice expressed as gram/mouse/day and the observation made at 24-48 Hrs, when administered at a dose of 30 mg/kg ChEMBL. 9526563
Food intake (functional) = 2.3 g mouse-1 day-1 Food intake in C57BL/ks Mice expressed as gram/mouse/day and the observation made at 24-48 Hrs, when administered at a dose of 30 mg/kg ChEMBL. 9526563
Food intake (functional) = 2.4 g mouse-1 day-1 Food intake in db/db Mice expressed as gram/mouse/day and the observation made at 0 - 24 Hrs, in db/db mice administered at a dose of 30 mg/kg ChEMBL. 9526563
Food intake (functional) = 2.4 g mouse-1 day-1 Food intake in db/db Mice expressed as gram/mouse/day and the observation made at 24 - 48 Hrs, in db/db mice administered at a dose of 30 mg/kg ChEMBL. 9526563
Food intake (functional) = 2.4 g mouse-1 day-1 Food intake in db/db Mice expressed as gram/mouse/day and the observation made at 0 - 24 Hrs, in db/db mice administered at a dose of 30 mg/kg ChEMBL. 9526563
Food intake (functional) = 2.4 g mouse-1 day-1 Food intake in db/db Mice expressed as gram/mouse/day and the observation made at 24 - 48 Hrs, in db/db mice administered at a dose of 30 mg/kg ChEMBL. 9526563
Food intake (functional) = 2.7 g mouse-1 day-1 Food intake in C57BL/ks Mice expressed as gram/mouse/day and the observation made at 0 -24 Hrs, when administered at a dose of 30 mg/kg ChEMBL. 9526563
Food intake (functional) = 2.7 g mouse-1 day-1 Food intake in C57BL/ks Mice expressed as gram/mouse/day and the observation made at 0 -24 Hrs, when administered at a dose of 30 mg/kg ChEMBL. 9526563
Food intake (functional) = 3.3 g mouse-1 day-1 Food intake in db/db Mice expressed as gram/mouse/day and the observation made at 0 - 24 Hrs, in db/db mice administered at a dose of 20 mg/kg ChEMBL. 9526563
Food intake (functional) = 3.3 g mouse-1 day-1 Food intake in db/db Mice expressed as gram/mouse/day and the observation made at 0 - 24 Hrs, in db/db mice administered at a dose of 20 mg/kg ChEMBL. 9526563
Food intake (functional) = 3.8 g mouse-1 day-1 Food intake in db/db Mice expressed as gram/mouse/day and the observation made at 24 - 48 Hrs, in db/db mice administered at a dose of 20 mg/kg ChEMBL. 9526563
Food intake (functional) = 3.8 g mouse-1 day-1 Food intake in db/db Mice expressed as gram/mouse/day and the observation made at 24 - 48 Hrs, in db/db mice administered at a dose of 20 mg/kg ChEMBL. 9526563
Glucose transport (functional) = 148 % In vitro glucose transport activity in 3T3-LI adipocytes at 3 microM concentration. ChEMBL. 9667966
Glucose transport (functional) = 148 % In vitro glucose transport activity in 3T3-LI adipocytes at 3 microM concentration. ChEMBL. 9667966
Glucose transport (functional) = 305 % In vitro glucose transport activity in 3T3-LI adipocytes at 10 microM concentration. ChEMBL. 9667966
Glucose transport (functional) = 305 % In vitro glucose transport activity in 3T3-LI adipocytes at 10 microM concentration. ChEMBL. 9667966
Glucose transport (functional) = 359 % In vitro glucose transport activity in 3T3-LI adipocytes at 30 microM concentration. ChEMBL. 9667966
Glucose transport (functional) = 359 % In vitro glucose transport activity in 3T3-LI adipocytes at 30 microM concentration. ChEMBL. 9667966
IC12 (functional) = 0.6 ug ml-1 Growth inhibition of Saccharomyces cerevisiae 1138 mutant by yeast bioassay ChEMBL. 10425120
IC12 (functional) = 0.6 ug ml-1 Growth inhibition of Saccharomyces cerevisiae 1140 mutant by yeast bioassay ChEMBL. 10425120
IC12 (functional) = 0.6 ug ml-1 Growth inhibition of Saccharomyces cerevisiae 1353 mutant by yeast bioassay ChEMBL. 10425120
IC20 (functional) = 7.5 uM Cytotoxicity against Saccharomyces cerevisiae ChEMBL. 18710911
IC40 (functional) = 17 uM Cytotoxicity against Saccharomyces cerevisiae ChEMBL. 18710911
IC50 (functional) = 1.72 M Inhibition of beta-hematin formation by BHIA assay ChEMBL. 15921407
IC50 (functional) = 41 ng/ml Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 infected human erythrocytes by [3H]hypoxanthine uptake ChEMBL. 9249972
IC50 (functional) = 52 ng/ml Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected human erythrocytes by [3H]hypoxanthine uptake ChEMBL. 9249972
IC50 (functional) = 222 nM Antiplasmodial activity against chloroquine-sensitive, mefloquine-resistant ring stage Plasmodium falciparum D6 infected in human red blood cells after 48 hrs ChEMBL. 21207937
IC50 (functional) = 259 nM Antiplasmodial activity against chloroquine and pyrimethamine-resistant ring stage Plasmodium falciparum V1/S infected in human red blood cells after 48 hrs ChEMBL. 21207937
IC50 (functional) = 424 nM Antiplasmodial activity against chloroquine-sensitive ring stage Plasmodium falciparum 3D7 infected in human red blood cells after 48 hrs ChEMBL. 21207937
IC50 (functional) = 755 nM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 ChEMBL. 18207399
IC50 (functional) = 755 nM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 ChEMBL. 18207399
IC50 (functional) = 755 nM Antiplasmodial activity against chloroquine-resistant ring stage Plasmodium falciparum W2 infected in human red blood cells after 48 hrs ChEMBL. 21207937
IC50 (ADMET) = 1180 nM Cytotoxicity against HUVEC cells ChEMBL. 18207399
IC50 (ADMET) = 1180 nM Cytotoxicity against HUVEC cells ChEMBL. 18207399
IC50 (functional) = 100000 nM Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 ChEMBL. 18395298
IC50 (functional) < 1 ug ml-1 Cytotoxicity against mouse M109 cells ChEMBL. 10425120
IC50 (functional) = 0.12 uM Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine incorporation assay ChEMBL. 19781948
IC50 (functional) = 0.12 uM Antiparasitic activity against Plasmodium falciparum K1 ChEMBL. 20133138
IC50 (functional) = 0.12 uM Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake ChEMBL. 15921407
IC50 (functional) = 0.22 uM Antitrypanosomal activity against Trypanosoma cruzi ChEMBL. 15921407
IC50 (functional) = 0.22 uM Antitrypanosomal activity against Trypanosoma cruzi ChEMBL. 19781948
IC50 (functional) = 0.44 uM In vitro antiplasmodial activity of the compound against Plasmodium falciparum ChEMBL. 15801861
IC50 (functional) = 0.44 uM In vitro antiplasmodial activity of the compound against Plasmodium falciparum ChEMBL. 15801861
IC50 (functional) = 0.6 uM Antitrypanosomal activity against Trypanosoma brucei rhodesiense ChEMBL. 15921407
IC50 (functional) = 0.6 uM Antitrypanosomal activity against Trypanosoma brucei rhodesiense ChEMBL. 19781948
IC50 (functional) = 0.8 uM Cytotoxicity against NQO2 expressing human RT112 cells in presence of NRH cofactor by MTT assay ChEMBL. 17643990
IC50 (functional) = 0.82 uM Cytotoxicity against NQO2 expressing human RT112 cells by MTT assay ChEMBL. 17643990
IC50 (functional) = 1.28 uM Cytotoxicity against low NQO1 protein expressing human BE cells by MTT assay ChEMBL. 17643990
IC50 (functional) = 1.45 uM Cytotoxicity against high NQO1 protein expressing human H460 cells by MTT assay ChEMBL. 17643990
IC50 (functional) = 1.75 uM In vitro cell survival assay on cancer KB cell lines ChEMBL. 11300877
IC50 (functional) = 2 uM Antitrypanosomal activity against Trypanosoma brucei brucei ChEMBL. 22926067
IC50 (functional) = 2.68 uM Antileishmanial activity against Leishmania donovani ChEMBL. 15921407
IC50 (functional) = 2.68 uM Antileishmanial activity against Leishmania donovani axenic amastigotes ChEMBL. 19781948
IC50 (functional) = 3.95 uM Cytotoxicity of the compound against MAC15A mouse adenocarcinomas of the colon cells ChEMBL. 15801861
IC50 (functional) = 3.95 uM Cytotoxicity of the compound against MAC15A mouse adenocarcinomas of the colon cells ChEMBL. 15801861
IC50 (functional) = 20.29 uM Cytotoxicity against Saccharomyces cerevisiae JN394 harboring deltarad52 mutant gene after 4 hrs ChEMBL. 18710911
IC50 (binding) = 23 uM Inhibition of Trypanosoma brucei rhodesiense rhodesain ChEMBL. 22926067
IC50 (functional) = 25.03 uM Cytotoxicity against Saccharomyces cerevisiae BY4741 harboring deltaerg6 mutant gene after 4 hrs ChEMBL. 18710911
IC50 (binding) = 64 uM Inhibition of Trypanosoma brucei CatB ChEMBL. 22926067
Inhibition (binding) Inhibition of IL1beta-induced p38 MAPK phosphorylation in human SK-N-SH cells at 10 to 20 uM preincubated for 30 mins prior to IL1beta-stimulation measured after 1 hr by Western blotting analysis ChEMBL. 23507189
Inhibition (binding) Inhibition of p38 MAPK in human SK-N-SH cells assessed as inhibition of IL1beta-induced MAPKAPK2 phosphorylation preincubated for 30 mins prior to IL1beta-stimulation measured after 1 hr by Western blotting analysis ChEMBL. 23507189
Inhibition (binding) Inhibition of IL1beta-induced NFkappaB p65 nuclear translocation in human SK-N-SH cells after 15 mins by ELISA ChEMBL. 23507189
Inhibition (functional) = 30 % Inhibition of LPS-stimulated nitric oxide production in mouse RAW 264.7 cells at 5 uM after 20 hrs relative to control ChEMBL. 17064915
Inhibition (functional) = 50 % Inhibition of LPS-stimulated nitric oxide production in mouse RAW 264.7 cells at 10 uM after 20 hrs relative to control ChEMBL. 17064915
Mean body weight (functional) = 22.7 g mouse-1 Mean body weight expressed as grams/mouse (C57BL/ks) at 48hrs, when given at 30 mg/kg ChEMBL. 9526563
Mean body weight (functional) = 22.7 g mouse-1 Mean body weight expressed as grams/mouse (C57BL/ks) at 48hrs, when given at 30 mg/kg ChEMBL. 9526563
Mean body weight (functional) = 23.3 g mouse-1 Mean body weight expressed as grams/mouse (C57BL/ks) at 24hrs, when given at 30 mg/kg ChEMBL. 9526563
Mean body weight (functional) = 23.3 g mouse-1 Mean body weight expressed as grams/mouse (C57BL/ks) at 24hrs, when given at 30 mg/kg ChEMBL. 9526563
Mean body weight (functional) = 23.7 g mouse-1 Mean body weight expressed as grams/mouse (C57BL/ks) at 0hrs, when given at 30 mg/kg ChEMBL. 9526563
Mean body weight (functional) = 23.7 g mouse-1 Mean body weight expressed as grams/mouse (C57BL/ks) at 0hrs, when given at 30 mg/kg ChEMBL. 9526563
Mean body weight (functional) = 35.5 g mouse-1 Compound was evaluated for the invivo effects on plasma glucose concentrations in db/db mice administered at a dose of 30 mg/kg mean body weight expressed as grams/mouse at 0 hr ChEMBL. 9526563
Mean body weight (functional) = 35.5 g mouse-1 Compound was evaluated for the invivo effects on plasma glucose concentrations in db/db mice administered at a dose of 30 mg/kg mean body weight expressed as grams/mouse at 0 hr ChEMBL. 9526563
Mean body weight (functional) = 36.9 g mouse-1 Compound was evaluated for the invivo effects on plasma glucose concentrations in db/db mice administered at a dose of 30 mg/kg mean body weight expressed as grams/mouse at 24 hr ChEMBL. 9526563
Mean body weight (functional) = 36.9 g mouse-1 Compound was evaluated for the invivo effects on plasma glucose concentrations in db/db mice administered at a dose of 30 mg/kg mean body weight expressed as grams/mouse at 24 hr ChEMBL. 9526563
Mean body weight (functional) = 37 g mouse-1 Compound was evaluated for the invivo effects on plasma glucose concentrations in db/db mice administered at a dose of 30 mg/kg mean body weight expressed as grams/mouse at 0 hr ChEMBL. 9526563
Mean body weight (functional) = 37 g mouse-1 Compound was evaluated for the invivo effects on plasma glucose concentrations in db/db mice administered at a dose of 30 mg/kg mean body weight expressed as grams/mouse at 0 hr ChEMBL. 9526563
Mean body weight (functional) = 37.4 g mouse-1 Compound was evaluated for the invivo effects on plasma glucose concentrations in db/db mice administered at a dose of 20 mg/kg mean body weight expressed as grams/mouse at 0 hr ChEMBL. 9526563
Mean body weight (functional) = 37.4 g mouse-1 Compound was evaluated for the invivo effects on plasma glucose concentrations in db/db mice administered at a dose of 20 mg/kg mean body weight expressed as grams/mouse at 0 hr ChEMBL. 9526563
Mean body weight (functional) = 37.9 g mouse-1 Compound was evaluated for the invivo effects on plasma glucose concentrations in db/db mice administered at a dose of 20 mg/kg mean body weight expressed as grams/mouse at 24 hr ChEMBL. 9526563
Mean body weight (functional) = 37.9 g mouse-1 Compound was evaluated for the invivo effects on plasma glucose concentrations in db/db mice administered at a dose of 20 mg/kg mean body weight expressed as grams/mouse at 24 hr ChEMBL. 9526563
Mean body weight (functional) = 38 g mouse-1 Compound was evaluated for the invivo effects on plasma glucose concentrations in db/db mice administered at a dose of 20 mg/kg mean body weight expressed as grams/mouse at 0 hr ChEMBL. 9526563
Mean body weight (functional) = 38 g mouse-1 Compound was evaluated for the invivo effects on plasma glucose concentrations in db/db mice administered at a dose of 20 mg/kg mean body weight expressed as grams/mouse at 0 hr ChEMBL. 9526563
Mean body weight (functional) = 39.8 g mouse-1 Mean body weight expressed as grams/mouse at 24hrs, when given at 100 mg/kg ChEMBL. 9526563
Mean body weight (functional) = 39.8 g mouse-1 Mean body weight measured in genetically altered obese diabetic mice(db/db) at 100 mg/kg at 24 h postdose ChEMBL. 9667966
Mean body weight (functional) = 39.8 g mouse-1 Mean body weight expressed as grams/mouse at 24hrs, when given at 100 mg/kg ChEMBL. 9526563
Mean body weight (functional) = 39.8 g mouse-1 Mean body weight measured in genetically altered obese diabetic mice(db/db) at 100 mg/kg at 24 h postdose ChEMBL. 9667966
Mean body weight (functional) = 41 g mouse-1 Mean body weight expressed as grams/mouse at 0hrs, when given at 100 mg/kg ChEMBL. 9526563
Mean body weight (functional) = 41 g mouse-1 Mean body weight measured in genetically altered obese diabetic mice(db/db) at 100 mg/kg at 0 h postdose ChEMBL. 9667966
Mean body weight (functional) = 41 g mouse-1 Mean body weight expressed as grams/mouse at 0hrs, when given at 100 mg/kg ChEMBL. 9526563
Mean body weight (functional) = 41 g mouse-1 Mean body weight measured in genetically altered obese diabetic mice(db/db) at 100 mg/kg at 0 h postdose ChEMBL. 9667966
Mean survival time (functional) day Mean survival time taken as number of days before illness due to Plasmodium berghei when mice treated with 20 mg/kg dose for 4 days; c=toxic after the 2nd dose ChEMBL. 15801861
Mean survival time (functional) day Mean survival time taken as number of days before illness due to Plasmodium berghei in untreated mice; c=toxic after the 2nd dose ChEMBL. 15801861
Mean survival time (functional) c 0 day Mean survival time taken as number of days before illness due to Plasmodium berghei in untreated mice; c=toxic after the 2nd dose ChEMBL. 15801861
Mean survival time (functional) c 0 day Mean survival time taken as number of days before illness due to Plasmodium berghei when mice treated with 20 mg/kg dose for 4 days; c=toxic after the 2nd dose ChEMBL. 15801861
Parasitemia (functional) % In vivo antimalarial activity of compound against Plasmodium berghei in mice at dose of 20 mg/kg treated for 4 days; c = toxic after 2nd dose ChEMBL. 15801861
Parasitemia (functional) c 0 % In vivo antimalarial activity of compound against Plasmodium berghei in mice at dose of 20 mg/kg treated for 4 days; c = toxic after 2nd dose ChEMBL. 15801861
Ratio (functional) = 8.98 Ratio of cytotoxic to that of antiplasmodial activity of the compound was determined ChEMBL. 15801861
Ratio IC50 (functional) = 2.9 Resistance index, ratio of IC50 for chloroquine-resistant ring stage Plasmodium falciparum W2 to IC50 for chloroquine-sensitive ring stage Plasmodium falciparum 3D7 ChEMBL. 21207937
Ratio IC50 (functional) = 1.6 Ratio of IC50 for human HUVEC cells to IC50 for Plasmodium falciparum W2 ChEMBL. 18207399
Suppression of parasitemia (functional) % In vivo antimalarial activity of compound against Plasmodium berghei was determined as supression of parasitemia in mice at 20 mg/kg treated for 4 days; c=toxic after the 2nd dose ChEMBL. 15801861
Suppression of parasitemia (functional) c 0 % In vivo antimalarial activity of compound against Plasmodium berghei was determined as supression of parasitemia in mice at 20 mg/kg treated for 4 days; c=toxic after the 2nd dose ChEMBL. 15801861

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 10425120
Plasmodium falciparum 15801861
Trypanosoma cruzi ChEMBL23 15921407
Leishmania donovani ChEMBL23 15921407
Homo sapiens ChEMBL23 17643990
Trypanosoma brucei gambiense 15921407

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

16 literature references were collected for this gene.

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