Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0041 | 0.004 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0041 | 0.0041 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.004 | 0.0041 | 0.0041 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.004 | 0.0041 | 0.0041 |
Onchocerca volvulus | 0.5983 | 1 | 1 | |
Onchocerca volvulus | 0.5983 | 1 | 1 | |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0041 | 0.004 |
Loa Loa (eye worm) | fibroinase | 0.0019 | 0.0006 | 0.0004 |
Schistosoma mansoni | hypothetical protein | 0.0905 | 0.149 | 0.149 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0041 | 0.004 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0023 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.5983 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.004 | 0.0041 | 0.0041 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0041 | 0.0041 |
Echinococcus multilocularis | GPCR, family 2 | 0.0051 | 0.0058 | 0.0058 |
Leishmania major | cathepsin L-like protease | 0.0073 | 0.0096 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.0022 | 0.1167 |
Brugia malayi | hypothetical protein | 0.014 | 0.0208 | 0.0206 |
Schistosoma mansoni | lipoxygenase | 0.013 | 0.0191 | 0.0191 |
Brugia malayi | Doublecortin family protein | 0.0022 | 0.001 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0156 | 0.0155 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.004 | 0.0041 | 0.004 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0496 | 0.0805 | 0.0805 |
Loa Loa (eye worm) | hypothetical protein | 0.0739 | 0.1212 | 0.1211 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0041 | 0.0041 |
Echinococcus multilocularis | voltage gated potassium channel | 0.004 | 0.0041 | 0.0041 |
Brugia malayi | cation channel family protein | 0.004 | 0.0041 | 0.004 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0023 | 0.0012 | 0.0012 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0023 | 0.0012 | 0.0011 |
Schistosoma mansoni | calcium-activated potassium channel | 0.004 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0054 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0012 | 0.0011 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0023 | 0.0012 | 0.0012 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.013 | 0.0191 | 0.0191 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0739 | 0.1212 | 0.1212 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0006 | 0.0004 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0739 | 0.1212 | 0.1212 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0019 | 0.0006 | 0.0006 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0019 | 0.0006 | 0.0173 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0023 | 0.0012 | 0.0011 |
Schistosoma mansoni | transient receptor potential channel | 0.004 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0041 | 0.004 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0041 | 0.0041 |
Schistosoma mansoni | vesicular amine transporter | 0.004 | 0.0041 | 0.0041 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0021 | 0.0009 | 0.0009 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0115 | 0.0166 | 1 |
Echinococcus multilocularis | sodium leak channel non selective protein | 0.004 | 0.0041 | 0.0041 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0023 | 0.0012 | 0.0012 |
Schistosoma mansoni | peripheral-type benzodiazepine receptor | 0.5983 | 1 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0019 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.5983 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0023 | 0.0012 | 0.0007 |
Leishmania major | cysteine peptidase A (CPA) | 0.0019 | 0.0006 | 0.0303 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0166 | 0.0164 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0739 | 0.1212 | 0.1211 |
Schistosoma mansoni | zinc finger protein | 0.0027 | 0.0018 | 0.0018 |
Brugia malayi | Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog | 0.004 | 0.0041 | 0.004 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.002 | 0.0007 | 0.0007 |
Echinococcus granulosus | neuropeptide s receptor | 0.0496 | 0.0805 | 0.0805 |
Schistosoma mansoni | voltage-gated potassium channel KCNQ | 0.004 | 0.0041 | 0.0041 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.004 | 0.0041 | 0.004 |
Schistosoma mansoni | thyroid hormone receptor | 0.0167 | 0.0253 | 0.0253 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0041 | 0.0041 |
Echinococcus multilocularis | cysteine protease | 0.0019 | 0.0006 | 0.0006 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0073 | 0.0096 | 0.5701 |
Echinococcus granulosus | transient receptor potential cation channel | 0.004 | 0.0041 | 0.0041 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.004 | 0.0041 | 0.0041 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.004 | 0.0041 | 0.0041 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0023 | 0.0012 | 0.0011 |
Leishmania major | cathepsin L-like protease | 0.0019 | 0.0006 | 0.0303 |
Onchocerca volvulus | Transient receptor potential cation channel trpm homolog | 0.004 | 0.0041 | 0.0035 |
Loa Loa (eye worm) | histone methyltransferase | 0.002 | 0.0006 | 0.0005 |
Echinococcus granulosus | sodium leak channel non selective protein | 0.004 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0041 | 0.004 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.004 | 0.0041 | 0.0041 |
Brugia malayi | Ryanodine Receptor TM 4-6 family protein | 0.004 | 0.0041 | 0.004 |
Echinococcus multilocularis | shaker cognate | 0.004 | 0.0041 | 0.0041 |
Echinococcus granulosus | voltage gated potassium channel | 0.004 | 0.0041 | 0.0041 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0023 | 0.0012 | 0.0012 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.004 | 0.0041 | 0.0041 |
Echinococcus granulosus | transient receptor potential cation channel | 0.004 | 0.0041 | 0.0041 |
Toxoplasma gondii | hypothetical protein | 0.004 | 0.0041 | 0.2033 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0058 | 0.0058 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0023 | 0.0012 | 0.0011 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0115 | 0.0166 | 1 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0022 | 0.001 | 0.2679 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0054 | 0.0063 | 0.0062 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.0096 | 0.5701 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.004 | 0.0041 | 0.004 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0019 | 0.0006 | 0.0006 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0051 | 0.0058 | 0.0058 |
Onchocerca volvulus | 0.0031 | 0.0025 | 0.002 | |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0041 | 0.0041 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0123 | 0.018 | 1 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0022 | 0.001 | 0.001 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0041 | 0.0041 |
Echinococcus multilocularis | RUN | 0.0022 | 0.001 | 0.001 |
Toxoplasma gondii | transporter, cation channel family protein | 0.004 | 0.0041 | 0.2033 |
Echinococcus granulosus | dnaJ subfamily B | 0.0905 | 0.149 | 0.149 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.004 | 0.0041 | 0.004 |
Echinococcus multilocularis | cysteine protease | 0.0019 | 0.0006 | 0.0006 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0115 | 0.0166 | 0.9175 |
Echinococcus multilocularis | musashi | 0.0031 | 0.0025 | 0.0025 |
Brugia malayi | Voltage-gated calcium channel, alpha subunit | 0.004 | 0.0041 | 0.004 |
Toxoplasma gondii | hypothetical protein | 0.0074 | 0.0098 | 0.5305 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0041 | 0.004 |
Echinococcus granulosus | translocator protein | 0.5983 | 1 | 1 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.004 | 0.0041 | 0.0041 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0292 | 0.0464 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0041 | 0.004 |
Onchocerca volvulus | Transient receptor potential cation channel trpm homolog | 0.004 | 0.0041 | 0.0035 |
Echinococcus granulosus | ryanodine receptor 44f | 0.004 | 0.0041 | 0.0041 |
Trypanosoma cruzi | ISWI complex protein | 0.0018 | 0.0004 | 0.005 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0024 | 0.0023 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0023 | 0.0012 | 0.0011 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0292 | 0.0464 | 0.0463 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0074 | 0.0097 | 0.0097 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0014 | 0.0014 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0041 | 0.0041 |
Onchocerca volvulus | Huntingtin homolog | 0.014 | 0.0208 | 0.0202 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.013 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0041 | 0.004 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0023 | 0.0012 | 0.0011 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.0063 | 0.0063 |
Schistosoma mansoni | transient receptor potential channel | 0.004 | 0.0041 | 0.0041 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0023 | 0.0012 | 0.0011 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.0008 | 0.0007 |
Echinococcus granulosus | cpg binding protein | 0.0069 | 0.009 | 0.009 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0739 | 0.1212 | 0.1212 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0041 | 0.0041 |
Echinococcus granulosus | FTZ F1 alpha | 0.0023 | 0.0012 | 0.0012 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0019 | 0.0006 | 0.5 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.004 | 0.0041 | 0.0041 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0041 | 0.0041 |
Echinococcus multilocularis | conserved hypothetical protein | 0.004 | 0.0041 | 0.0041 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.004 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0023 | 0.0012 | 0.0011 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0022 | 0.001 | 0.001 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0023 | 0.0012 | 0.0011 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.0096 | 0.5701 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0025 | 0.0024 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0023 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0112 | 0.0111 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0012 | 0.0011 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.004 | 0.0041 | 0.0041 |
Brugia malayi | Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog | 0.004 | 0.0041 | 0.004 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.004 | 0.0041 | 0.2033 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.0295 | 0.6321 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.004 | 0.0041 | 0.0041 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.004 | 0.0041 | 0.2033 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0025 | 0.0025 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.004 | 0.0041 | 0.0041 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.002 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0041 | 0.004 |
Loa Loa (eye worm) | voltage-gated potassium channel | 0.004 | 0.0041 | 0.004 |
Schistosoma mansoni | 60S ribosomal protein L21 | 0.004 | 0.0041 | 0.0041 |
Brugia malayi | Transient-receptor-potential like protein | 0.004 | 0.0041 | 0.004 |
Schistosoma mansoni | voltage-gated ion channel | 0.004 | 0.0041 | 0.0041 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0051 | 0.0058 | 0.0057 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0739 | 0.1212 | 0.1212 |
Brugia malayi | Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog | 0.004 | 0.0041 | 0.004 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0022 | 0.001 | 0.2679 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0023 | 0.0012 | 0.0012 |
Brugia malayi | nuclear receptor NHR-88 | 0.0023 | 0.0012 | 0.0011 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0041 | 0.004 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.004 | 0.0041 | 0.0774 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.004 | 0.0041 | 0.0041 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.004 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | voltage-gated calcium channel | 0.004 | 0.0041 | 0.004 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0023 | 0.0012 | 0.0012 |
Echinococcus multilocularis | voltage gated potassium channel | 0.004 | 0.0041 | 0.0041 |
Echinococcus granulosus | geminin | 0.0193 | 0.0298 | 0.0298 |
Brugia malayi | olfactory channel protein osm-9 | 0.004 | 0.0041 | 0.004 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0496 | 0.0805 | 0.0805 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.0295 | 0.6321 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0012 | 0.0011 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0022 | 0.001 | 0.001 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0023 | 0.0012 | 0.0011 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0066 | 0.0085 | 0.505 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0041 | 0.004 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0023 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | ion channel NompC | 0.004 | 0.0041 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0049 | 0.0048 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0023 | 0.0012 | 0.0011 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0144 | 0.0214 | 0.0214 |
Loa Loa (eye worm) | ryanodine receptor | 0.004 | 0.0041 | 0.004 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0905 | 0.149 | 0.149 |
Brugia malayi | Cytochrome P450 family protein | 0.0017 | 0.0003 | 0.0002 |
Echinococcus multilocularis | potassium voltage gated channel subfamily D | 0.004 | 0.0041 | 0.0041 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.003 | 0.0024 | 0.0024 |
Echinococcus granulosus | potassium voltage gated channel subfamily D | 0.004 | 0.0041 | 0.0041 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0042 | 0.0044 | 0.0044 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.0063 | 0.0063 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.0127 | 0.0126 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0041 | 0.0041 |
Echinococcus granulosus | two pore calcium channel protein 1 | 0.004 | 0.0041 | 0.0041 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0073 | 0.0096 | 0.5701 |
Echinococcus granulosus | transient receptor potential cation channel | 0.004 | 0.0041 | 0.0041 |
Trypanosoma cruzi | ISWI complex protein | 0.0018 | 0.0004 | 0.005 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.004 | 0.0041 | 0.0041 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.0298 | 0.0298 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.003 | 0.0024 | 0.0024 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0019 | 0.0006 | 0.0006 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.004 | 0.0041 | 0.0041 |
Leishmania major | hypothetical protein, unknown function | 0.004 | 0.0041 | 0.4123 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0012 | 0.0011 |
Schistosoma mansoni | voltage-gated cation channel | 0.0739 | 0.1212 | 0.1212 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.0096 | 0.5701 |
Schistosoma mansoni | hypothetical protein | 0.0109 | 0.0156 | 0.0156 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.0063 | 0.0063 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0058 | 0.0058 |
Echinococcus granulosus | shaker cognate | 0.004 | 0.0041 | 0.0041 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.0063 | 0.0063 |
Onchocerca volvulus | Huntingtin homolog | 0.014 | 0.0208 | 0.0202 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0019 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0023 | 0.0012 | 0.0011 |
Onchocerca volvulus | 0.5983 | 1 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0019 | 0.0006 | 0.0006 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.016 | 0.0241 | 0.024 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.004 | 0.0041 | 0.004 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0023 | 0.0012 | 0.0012 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0041 | 0.4123 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0073 | 0.0096 | 0.5701 |
Schistosoma mansoni | bromodomain containing protein | 0.0078 | 0.0104 | 0.0104 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0041 | 0.004 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0019 | 0.0006 | 0.0006 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0005 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.001 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0041 | 0.004 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.0096 | 0.5701 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.004 | 0.0041 | 0.0041 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0058 | 0.0058 |
Echinococcus granulosus | zinc finger protein | 0.0027 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0098 | 0.0097 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0192 | 0.0295 | 0.029 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0022 | 0.001 | 0.0009 |
Brugia malayi | hypothetical protein | 0.0022 | 0.001 | 0.0009 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.004 | 0.0041 | 0.0041 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0021 | 0.0009 | 0.0009 |
Echinococcus granulosus | transient receptor potential cation channel | 0.004 | 0.0041 | 0.0041 |
Schistosoma mansoni | transient receptor potential cation channel subfamily m member | 0.004 | 0.0041 | 0.0041 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0292 | 0.0464 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0041 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0063 | 0.0062 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0109 | 0.0156 | 0.0155 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0041 | 0.004 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0022 | 0.0021 |
Echinococcus granulosus | microtubule associated protein 2 | 0.1422 | 0.2357 | 0.2357 |
Brugia malayi | Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog | 0.004 | 0.0041 | 0.004 |
Echinococcus granulosus | transient receptor potential cation channel | 0.004 | 0.0041 | 0.0041 |
Schistosoma mansoni | nuclear hormone receptor | 0.0023 | 0.0012 | 0.0012 |
Echinococcus granulosus | two pore calcium channel protein 2 | 0.004 | 0.0041 | 0.0041 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0739 | 0.1212 | 0.1212 |
Echinococcus granulosus | potassium voltage gated channel subfamily D | 0.004 | 0.0041 | 0.0041 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.0295 | 0.6321 |
Echinococcus granulosus | GPCR family 2 | 0.0051 | 0.0058 | 0.0058 |
Echinococcus multilocularis | potassium large conductance calcium activated | 0.004 | 0.0041 | 0.0041 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0739 | 0.1212 | 0.1212 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0025 | 0.0025 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.004 | 0.0041 | 0.004 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.004 | 0.0041 | 0.0041 |
Echinococcus multilocularis | sodium channel protein | 0.004 | 0.0041 | 0.0041 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0051 | 0.0058 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0041 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0022 | 0.0021 |
Leishmania major | cathepsin L-like protease | 0.0019 | 0.0006 | 0.0303 |
Schistosoma mansoni | transient receptor potential cation channel subfamily m member | 0.004 | 0.0041 | 0.0041 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0006 | 0.0004 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0054 | 0.0063 | 0.0062 |
Onchocerca volvulus | 0.0023 | 0.0012 | 0.0007 | |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0023 | 0.0012 | 0.0012 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0023 | 0.0012 | 0.0012 |
Schistosoma mansoni | zinc finger protein | 0.0018 | 0.0004 | 0.0004 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.0096 | 0.5701 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0208 | 0.0206 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0023 | 0.0012 | 0.0011 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.004 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0024 | 0.0014 | 0.0013 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0022 | 0.1167 |
Schistosoma mansoni | transient receptor potential channel | 0.004 | 0.0041 | 0.0041 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.004 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0029 | 0.0022 | 0.0021 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.004 | 0.0041 | 0.0041 |
Echinococcus granulosus | potassium channel KvQLT family member kqt 1 | 0.004 | 0.0041 | 0.0041 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0025 | 0.0025 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.0096 | 0.5701 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0022 | 0.001 | 0.001 |
Echinococcus granulosus | voltage gated hydrogen channel 1 | 0.004 | 0.0041 | 0.0041 |
Brugia malayi | nuclear hormone receptor | 0.0023 | 0.0012 | 0.0011 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0012 | 0.0011 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.0022 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0041 | 0.004 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.004 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0012 | 0.0011 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.016 | 0.0241 | 0.024 |
Schistosoma mansoni | rab6-interacting | 0.0022 | 0.001 | 0.001 |
Schistosoma mansoni | cpg binding protein | 0.0069 | 0.009 | 0.009 |
Echinococcus multilocularis | geminin | 0.0193 | 0.0298 | 0.0298 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0017 | 0.0003 | 0.0002 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0292 | 0.0464 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0023 | 0.0012 | 0.0011 |
Echinococcus multilocularis | translocator protein | 0.5983 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0022 | 0.1167 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0023 | 0.0012 | 0.0011 |
Brugia malayi | Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit | 0.004 | 0.0041 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.5983 | 1 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1422 | 0.2357 | 0.2357 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0021 | 0.0009 | 0.0009 |
Schistosoma mansoni | cpg binding protein | 0.0064 | 0.008 | 0.008 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0241 | 0.024 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1422 | 0.2357 | 0.2357 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0023 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | voltage-gated potassium channel | 0.004 | 0.0041 | 0.004 |
Echinococcus granulosus | sodium channel protein | 0.004 | 0.0041 | 0.0041 |
Echinococcus multilocularis | voltage gated hydrogen channel 1 | 0.004 | 0.0041 | 0.0041 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0292 | 0.0464 | 1 |
Onchocerca volvulus | 0.004 | 0.0041 | 0.0035 | |
Loa Loa (eye worm) | voltage-dependent calcium channel | 0.0115 | 0.0166 | 0.0164 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0019 | 0.0006 | 0.0004 |
Schistosoma mansoni | hypothetical protein | 0.0144 | 0.0214 | 0.0214 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0739 | 0.1212 | 0.1212 |
Echinococcus granulosus | cathepsin l1 | 0.0019 | 0.0006 | 0.0006 |
Schistosoma mansoni | lamin | 0.0031 | 0.0025 | 0.0025 |
Schistosoma mansoni | two-pore calcium channel | 0.004 | 0.0041 | 0.0041 |
Brugia malayi | Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog | 0.004 | 0.0041 | 0.004 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.004 | 0.0041 | 0.0041 |
Echinococcus granulosus | hypothetical protein | 0.004 | 0.0041 | 0.0041 |
Brugia malayi | hypothetical protein | 0.2415 | 0.4022 | 0.4021 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0208 | 0.0206 |
Brugia malayi | ecdysteroid receptor | 0.0023 | 0.0012 | 0.0011 |
Loa Loa (eye worm) | cysteine protease | 0.0019 | 0.0006 | 0.0004 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0292 | 0.0464 | 0.0463 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.0295 | 0.6321 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0057 | 0.0069 | 0.4097 |
Loa Loa (eye worm) | hypothetical protein | 0.5983 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.001 | 0.001 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0496 | 0.0805 | 0.0805 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0023 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0051 | 0.0058 | 0.0057 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0023 | 0.0012 | 0.0011 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.004 | 0.0041 | 0.0041 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.004 | 0.0041 | 0.0041 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0019 | 0.0006 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit | 0.004 | 0.0041 | 0.004 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0292 | 0.0464 | 1 |
Toxoplasma gondii | hypothetical protein | 0.004 | 0.0041 | 0.2033 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0041 | 0.0041 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0023 | 0.0012 | 0.0007 |
Brugia malayi | voltage-dependent calcium channel | 0.004 | 0.0041 | 0.004 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0023 | 0.0012 | 0.0011 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.004 | 0.0041 | 0.0041 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0023 | 0.0012 | 0.0012 |
Echinococcus granulosus | calcium activated potassium channel | 0.004 | 0.0041 | 0.0041 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0925 | 0.1525 | 0.1525 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0041 | 0.0041 |
Echinococcus multilocularis | two pore calcium channel protein 1 | 0.004 | 0.0041 | 0.0041 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.004 | 0.0041 | 0.0041 |
Schistosoma mansoni | lipoxygenase | 0.0091 | 0.0126 | 0.0126 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.0096 | 0.5701 |
Leishmania major | cathepsin L-like protease | 0.0073 | 0.0096 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0021 | 0.0009 | 0.0009 |
Brugia malayi | Bromodomain containing protein | 0.0045 | 0.0049 | 0.0048 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0064 | 0.008 | 0.0079 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0023 | 0.0012 | 0.0011 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0023 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0025 | 0.0024 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0023 | 0.0012 | 0.0011 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.0096 | 0.5701 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0115 | 0.0166 | 0.0166 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.016 | 0.0241 | 0.024 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0025 | 0.0024 |
Echinococcus multilocularis | potassium voltage gated channel subfamily D | 0.004 | 0.0041 | 0.0041 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.004 | 0.0041 | 0.0041 |
Schistosoma mansoni | rab6-interacting | 0.0022 | 0.001 | 0.001 |
Schistosoma mansoni | polycystin 1-related | 0.0022 | 0.001 | 0.001 |
Echinococcus multilocularis | calcium activated potassium channel | 0.004 | 0.0041 | 0.0041 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0023 | 0.0012 | 0.0012 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0006 | 0.0004 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.0025 | 0.0025 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0042 | 0.0044 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0012 | 0.0011 |
Brugia malayi | hypothetical protein | 0.004 | 0.0041 | 0.004 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0025 | 0.0024 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0025 | 0.0024 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0019 | 0.0006 | 0.0004 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.004 | 0.0041 | 0.235 |
Schistosoma mansoni | transient receptor potential cation channel subfamily m member | 0.004 | 0.0041 | 0.0041 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.004 | 0.0041 | 0.0041 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0023 | 0.0012 | 0.0012 |
Brugia malayi | CXXC zinc finger family protein | 0.0064 | 0.008 | 0.0079 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0023 | 0.0012 | 0.0011 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0739 | 0.1212 | 0.1212 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0051 | 0.0058 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0041 | 0.004 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0022 | 0.001 | 0.001 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.004 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0009 | 0.0008 |
Brugia malayi | PHD-finger family protein | 0.0033 | 0.0029 | 0.0027 |
Mycobacterium ulcerans | tryptophan-rich sensory protein | 0.5983 | 1 | 1 |
Onchocerca volvulus | 0.5983 | 1 | 1 | |
Onchocerca volvulus | 0.0064 | 0.008 | 0.0075 | |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.004 | 0.0041 | 0.0041 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0041 | 0.0041 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.004 | 0.0041 | 0.0041 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.002 | 0.0006 | 0.0006 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0144 | 0.0214 | 0.0214 |
Echinococcus granulosus | potassium voltage gated channel subfamily D | 0.004 | 0.0041 | 0.0041 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.004 | 0.0041 | 0.0041 |
Echinococcus multilocularis | cpg binding protein | 0.0069 | 0.009 | 0.009 |
Schistosoma mansoni | cpg binding protein | 0.0069 | 0.009 | 0.009 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0023 | 0.0012 | 0.0012 |
Echinococcus multilocularis | potassium voltage gated channel subfamily D | 0.004 | 0.0041 | 0.0041 |
Echinococcus granulosus | lamin | 0.0031 | 0.0025 | 0.0025 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0004 | 0.0004 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.004 | 0.0041 | 0.0041 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0058 | 0.0058 |
Schistosoma mansoni | thyroid hormone receptor | 0.0167 | 0.0253 | 0.0253 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.0096 | 0.5701 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0041 | 0.0041 |
Schistosoma mansoni | lamin | 0.0031 | 0.0025 | 0.0025 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0025 | 0.0025 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.004 | 0.0041 | 0.0774 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0019 | 0.0006 | 0.0006 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.004 | 0.0041 | 0.0041 |
Leishmania major | cathepsin L-like protease | 0.0019 | 0.0006 | 0.0303 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.004 | 0.0041 | 0.0041 |
Echinococcus granulosus | potassium voltage gated channel subfamily C | 0.004 | 0.0041 | 0.0041 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.004 | 0.0041 | 0.0041 |
Brugia malayi | hypothetical protein | 0.0022 | 0.001 | 0.0009 |
Brugia malayi | Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog | 0.004 | 0.0041 | 0.004 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.003 | 0.0024 | 0.0024 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0023 | 0.0012 | 0.0011 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.004 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0012 | 0.0011 |
Loa Loa (eye worm) | calcium channel | 0.0739 | 0.1212 | 0.1211 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.0295 | 0.6321 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0058 | 0.0057 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0022 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0073 | 0.0096 | 0.5701 |
Leishmania major | hypothetical protein, conserved | 0.0018 | 0.0004 | 0.0088 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0051 | 0.0058 | 0.0058 |
Schistosoma mansoni | coup transcription factor | 0.0023 | 0.0012 | 0.0012 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.004 | 0.0041 | 0.0041 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0739 | 0.1212 | 0.1212 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0023 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.004 | 0.0041 | 0.004 |
Schistosoma mansoni | ryanodine receptor related | 0.004 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0023 | 0.0012 | 0.0011 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.004 | 0.0041 | 0.0041 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.0295 | 0.6321 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0135 | 0.0199 | 0.0199 |
Echinococcus granulosus | Potassium voltage gated channel protein Shaw | 0.004 | 0.0041 | 0.0041 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0202 | 0.0312 | 0.6699 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.001 | 0.0009 |
Schistosoma mansoni | calcium channel voltage-dependent p/q type alpha 1a-related | 0.004 | 0.0041 | 0.0041 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0006 | 0.0004 |
Leishmania major | cathepsin L-like protease | 0.0019 | 0.0006 | 0.0303 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.004 | 0.0041 | 0.0041 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0051 | 0.0058 | 0.0057 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0019 | 0.0006 | 0.0004 |
Schistosoma mansoni | loxhd1 | 0.0022 | 0.001 | 0.001 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0022 | 0.001 | 0.001 |
Brugia malayi | Cytochrome P450 family protein | 0.0017 | 0.0003 | 0.0002 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0023 | 0.0012 | 0.0012 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0023 | 0.0012 | 0.0012 |
Echinococcus granulosus | potassium large conductance calcium activated | 0.004 | 0.0041 | 0.0041 |
Trypanosoma brucei | ISWI complex protein | 0.0018 | 0.0004 | 0.005 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0006 | 0.0004 |
Echinococcus granulosus | voltage gated potassium channel | 0.004 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0041 | 0.004 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.004 | 0.0041 | 0.0041 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.004 | 0.0041 | 0.0041 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.004 | 0.0041 | 0.0041 |
Toxoplasma gondii | transporter, cation channel family protein | 0.004 | 0.0041 | 0.2033 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.004 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0098 | 0.0097 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.004 | 0.0041 | 0.0041 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.004 | 0.0041 | 0.4123 |
Echinococcus multilocularis | two pore calcium channel protein 2 | 0.004 | 0.0041 | 0.0041 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0292 | 0.0464 | 1 |
Onchocerca volvulus | 0.0022 | 0.001 | 0.0004 | |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0739 | 0.1212 | 0.1212 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0023 | 0.0012 | 0.0011 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0017 | 0.0003 | 0.0002 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0167 | 0.0253 | 0.0253 |
Brugia malayi | Cytochrome P450 family protein | 0.0029 | 0.0022 | 0.0021 |
Entamoeba histolytica | cysteine protease, putative | 0.0019 | 0.0006 | 0.5 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.004 | 0.0041 | 0.0041 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0023 | 0.0012 | 0.0011 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0006 | 0.0004 |
Echinococcus granulosus | RUN | 0.0022 | 0.001 | 0.001 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0023 | 0.0012 | 0.0007 |
Loa Loa (eye worm) | doublecortin family protein | 0.0022 | 0.001 | 0.0009 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0006 | 0.0004 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.002 | 0.0007 | 0.0007 |
Echinococcus multilocularis | zinc finger protein | 0.0027 | 0.0018 | 0.0018 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0023 | 0.0012 | 0.0012 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.0096 | 0.5701 |
Onchocerca volvulus | 0.0022 | 0.001 | 0.0004 | |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.004 | 0.0041 | 0.0041 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.004 | 0.0041 | 0.0041 |
Brugia malayi | Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit | 0.004 | 0.0041 | 0.004 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.004 | 0.0041 | 0.0041 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0041 | 0.0041 |
Schistosoma mansoni | voltage-dependent calcium channel | 0.004 | 0.0041 | 0.0041 |
Leishmania major | cathepsin L-like protease | 0.0073 | 0.0096 | 1 |
Brugia malayi | steroid hormone receptor | 0.0023 | 0.0012 | 0.0011 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0023 | 0.0012 | 0.0012 |
Brugia malayi | cation channel family protein | 0.004 | 0.0041 | 0.004 |
Brugia malayi | ion channel NompC | 0.004 | 0.0041 | 0.004 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0739 | 0.1212 | 0.1212 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.0063 | 0.0063 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.004 | 0.0041 | 0.235 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0017 | 0.0003 | 0.0002 |
Schistosoma mansoni | transient receptor potential cation channel subfamily m member | 0.004 | 0.0041 | 0.0041 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.0096 | 0.5701 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0041 | 0.004 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.002 | 0.0007 | 0.0007 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0022 | 0.2047 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.0295 | 0.6321 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | ctsf protein | 0.0019 | 0.0006 | 0.0004 |
Onchocerca volvulus | 0.0031 | 0.0025 | 0.002 | |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0074 | 0.0097 | 0.0097 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0023 | 0.0012 | 0.0012 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0022 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.0298 | 0.0298 |
Echinococcus multilocularis | transfer RNA-Gly | 0.004 | 0.0041 | 0.0041 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.0022 | 0.0928 |
Echinococcus multilocularis | potassium voltage gated channel subfamily C | 0.004 | 0.0041 | 0.0041 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.002 | 0.0007 | 0.0007 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0739 | 0.1212 | 0.1212 |
Echinococcus granulosus | transient receptor potential cation channel | 0.004 | 0.0041 | 0.0041 |
Leishmania major | cathepsin L-like protease | 0.0019 | 0.0006 | 0.0303 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0202 | 0.0312 | 0.6699 |
Schistosoma mansoni | transient receptor potential cation channel subfamily m member | 0.004 | 0.0041 | 0.0041 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AUC (ADMET) | = 93 ng ml-1 hr-1 | pharmacokinetic parameter area under the curve (AUC) was reported in rat after oral administration | ChEMBL. | 12190311 |
AUC (ADMET) | = 286 ng ml-1 hr-1 | pharmacokinetic parameter area under the curve (AUC) was reported in dog after intravenous administration | ChEMBL. | 12190311 |
AUC (ADMET) | = 308 ng ml-1 hr-1 | pharmacokinetic parameter area under the curve (AUC) was reported in dog after oral administration | ChEMBL. | 12190311 |
AUC (ADMET) | = 392 ng ml-1 hr-1 | pharmacokinetic parameter area under the curve (AUC) was reported in rat after intravenous administration | ChEMBL. | 12190311 |
Clp (ADMET) | = 39 | pharmacokinetic parameter plasma clearance was reported in dog after intravenous administration | ChEMBL. | 12190311 |
Clp (ADMET) | = 85 | pharmacokinetic parameter plasma clearance was reported in rat after intravenous administration | ChEMBL. | 12190311 |
Cmax (ADMET) | = 138 ng ml-1 | Pharmacokinetic paramater Cmax was reported after in dog oral administration | ChEMBL. | 12190311 |
Cmax (ADMET) | = 147 ng ml-1 | Pharmacokinetic paramater Cmax was reported after in rat oral administration | ChEMBL. | 12190311 |
F (ADMET) | = 24 % | Oral bioavailability in rat | ChEMBL. | 12190311 |
F (ADMET) | = 100 % | Oral bioavailability in dog | ChEMBL. | 12190311 |
IC50 (binding) | = 0.01 uM | The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) | ChEMBL. | 12190311 |
IC50 (binding) | = 0.25 uM | The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) using whole blood assay | ChEMBL. | 12190311 |
IC50 (binding) | = 0.39 uM | The compound was evaluated for its inhibitory activity against dog neutrophil elastase using whole blood assay | ChEMBL. | 12190311 |
IC50 (binding) | = 3 uM | The compound was evaluated for its inhibitory activity against Chymotrypsinogen using selectivity assay | ChEMBL. | 12190311 |
IC50 (binding) | > 100 uM | The compound was evaluated for its inhibitory activity against trypsin using selectivity assay | ChEMBL. | 12190311 |
IC50 (binding) | > 100 uM | The compound was evaluated for its inhibitory activity against cathepsin G using selectivity assay | ChEMBL. | 12190311 |
Inhibition (binding) | = 65 % | The compound was evaluated for its % Elastase inhibition in bone marrow at a concentration of 2.2 mg/kg orally | ChEMBL. | 12190311 |
Inhibition (binding) | = 93 % | The compound was evaluated for its % Elastase inhibition in bronchoalveolar lavage at a concentration of 2.2 mg/kg orally | ChEMBL. | 12190311 |
Inhibition (binding) | = 100 % | Compound at a concentration of 2 mg/kg administered orally and evaluated for its % Elastase inhibition in peripheral blood after 6 hours | ChEMBL. | 12190311 |
Inhibition (functional) | = 100 % | Compound at a concentration of 2 mg/kg administered orally and evaluated for its % Elastase inhibition in peripheral blood after 3 days | ChEMBL. | 12190311 |
k obs / 1 (binding) | = 3483 | The kinetic parameter of the compound Kobs at pH 7.4 was reported against Elastase | ChEMBL. | 12190311 |
Ki (binding) | = 0.16 nM | The compound was evaluated for its binding affinity towards human neutrophil elastase (HNE) | ChEMBL. | 12190311 |
koff (binding) | = 4.85 *10e6/s | Association rate constant of the compound at pH 7.4 against Elastase | ChEMBL. | 12190311 |
kon (binding) | = 30505 M-1 s-1 | Dissociation rate constant of the compound at pH 7.4 against Elastase | ChEMBL. | 12190311 |
T max (ADMET) | = 0.03 hr | Pharmacokinetic parameter Tmax was reported in rat after intravenous administration | ChEMBL. | 12190311 |
T max (ADMET) | = 0.03 hr | Pharmacokinetic parameter Tmax was reported in dog after intravenous administration | ChEMBL. | 12190311 |
T max (ADMET) | = 0.25 hr | Pharmacokinetic parameter Tmax was reported in rat after oral administration | ChEMBL. | 12190311 |
T max (ADMET) | = 0.5 hr | Pharmacokinetic parameter Tmax was reported in dog after oral administration | ChEMBL. | 12190311 |
T1/2 (ADMET) | = 0.4 hr | half life of the compound was reported in rat after intravenous administration | ChEMBL. | 12190311 |
T1/2 (ADMET) | = 1 hr | half life of the compound was reported in dog after intravenous administration | ChEMBL. | 12190311 |
T1/2 (ADMET) | = 1.3 hr | half life of the compound was reported in rat after oral administration | ChEMBL. | 12190311 |
T1/2 (ADMET) | = 1.4 hr | half life of the compound was reported in dog after oral administration | ChEMBL. | 12190311 |
Vd area (ADMET) | = 2.6 l kg-1 | pharmacokinetic parameter volume of distribution (Vd) was reported in rat after intravenous administration | ChEMBL. | 12190311 |
Vd area (ADMET) | = 3.4 l kg-1 | pharmacokinetic parameter volume of distribution (Vd) was reported in dog after intravenous administration | ChEMBL. | 12190311 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.