Detailed information for compound 54698

Basic information

Technical information
  • TDR Targets ID: 54698
  • Name: N-(3-methyl-1,1-dioxo-1,4-thiazinan-4-yl)-1-( 5-nitrofuran-2-yl)methanimine
  • MW: 287.292 | Formula: C10H13N3O5S
  • H donors: 0 H acceptors: 4 LogP: 1.26 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CS(=O)(=O)CCN1/N=C/c1ccc(o1)[N+](=O)[O-]
  • InChi: 1S/C10H13N3O5S/c1-8-7-19(16,17)5-4-12(8)11-6-9-2-3-10(18-9)13(14)15/h2-3,6,8H,4-5,7H2,1H3/b11-6+
  • InChiKey: ARFHIAQFJWUCFH-IZZDOVSWSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3-methyl-1,1-dioxo-1,4-thiazinan-4-yl)-1-(5-nitro-2-furyl)methanimine
  • (E)-(1,1-diketo-3-methyl-1,4-thiazinan-4-yl)-[(5-nitro-2-furyl)methylene]amine
  • Nifurtimox
  • (1,1-diketo-3-methyl-1,4-thiazinan-4-yl)-[(5-nitro-2-furyl)methylene]amine
  • 23256-30-6
  • C08002
  • SPBio_003068
  • Prestwick3_001024
  • Prestwick1_001024
  • Prestwick2_001024
  • Prestwick0_001024
  • 3-Methyl-N-[(5-nitro-2-furanyl)methylene]-4-thiomorpholinamine 1,1-dioxide
  • AIDS-007325
  • AIDS007325
  • BSPBio_001207
  • 1-((5-Nitrofurfurylidene)amino)-2-methyltetrahydro-1,4-thiazine-4,4-dioxide
  • 3-Methyl-4-(5'-nitrofurylidene-amino)-tetrahydro-4H-1,4-thiazine-1,1-dioxide
  • 4-((5-Nitrofurfurylidene)amino)-3-methylthiomorpholine 1,1-dioxide
  • 4-((5-Nitrofurfurylidene)amino)-3-methylthiomorpholine-1,1-dioxide
  • 4-Thiomorpholinamine, 3-methyl-N-((5-nitro-2-furanyl)methylene)-, 1,1-dioxide
  • BAY 2502
  • Bayer 2502
  • CCRIS 2201
  • EINECS 245-531-0
  • Lampit
  • Nifurtimox [BAN:INN]
  • Nifurtimoxum [INN-Latin]
  • Tetrahydro-3-methyl-4-((5-nitrofurfurylidene)amino)-2H-1,4-thiazine 1,1-dioxide
  • Thiomorpholine, 3-methyl-4-((5-nitrofurfurylidene)amino)-, 1,1-dioxide
  • D00833
  • Lampit (TN)
  • Nifurtimox (INN)
  • BPBio1_001329

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi nitroreductase Curated by TDR Targets No references
Leishmania major trypanothione reductase Curated by TDR Targets References
Trypanosoma cruzi nitroreductase Curated by TDR Targets No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis nitroreductase-like protein Get druggable targets OG5_132153 All targets in OG5_132153
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum nitroreductase-like protein Get druggable targets OG5_132153 All targets in OG5_132153
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi nitroreductase Get druggable targets OG5_132153 All targets in OG5_132153
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei nitroreductase Get druggable targets OG5_132153 All targets in OG5_132153
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani nitroreductase-like protein Get druggable targets OG5_132153 All targets in OG5_132153
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense nitroreductase Get druggable targets OG5_132153 All targets in OG5_132153
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi nitroreductase Get druggable targets OG5_132153 All targets in OG5_132153
Trypanosoma brucei gambiense nitroreductase, putative,NADH dehydrogenase, putative Get druggable targets OG5_132153 All targets in OG5_132153
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major nitroreductase-like protein Get druggable targets OG5_132153 All targets in OG5_132153
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana nitroreductase-like protein Get druggable targets OG5_132153 All targets in OG5_132153
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast trypanothione reductase 491 aa 551 aa 23.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cathepsin l1 0.00516513 0.00678298 0.00678298
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0930775 0.302524 0.383888
Brugia malayi Cathepsin L-like precursor 0.00732058 0.014034 0.018542
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.00732058 0.014034 0.0364886
Plasmodium vivax aspartyl protease, putative 0.00454365 0.00469231 0.00380416
Echinococcus multilocularis g protein coupled receptor 0.0930775 0.302524 0.302524
Echinococcus granulosus histone deacetylase 8 0.00994152 0.022851 0.022851
Brugia malayi hypothetical protein 0.0930775 0.302524 0.399699
Echinococcus multilocularis tubulin subunit beta 0.105208 0.34333 0.34333
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.00415925 0.00339916 0.00621811
Schistosoma mansoni biogenic amine receptor 0.0930775 0.302524 0.383888
Loa Loa (eye worm) TK/ABL protein kinase 0.0258375 0.0763257 0.198447
Toxoplasma gondii aspartyl protease ASP3 0.00454365 0.00469231 0.0122217
Onchocerca volvulus 0.0930775 0.302524 1
Trichomonas vaginalis conserved hypothetical protein 0.0142889 0.0374758 0.100246
Echinococcus multilocularis cysteine protease 0.00732058 0.014034 0.014034
Leishmania major cathepsin L-like protease 0.00732058 0.014034 0.0373089
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0930775 0.302524 0.302524
Echinococcus multilocularis histone deacetylase 8 0.00994152 0.022851 0.022851
Brugia malayi hypothetical protein 0.0930775 0.302524 0.399699
Toxoplasma gondii cathepsin B 0.0100098 0.0230807 0.0658592
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00732058 0.014034 0.0312854
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0100098 0.0230807 0.0637568
Echinococcus multilocularis tyrosine protein kinase Blk 0.00863583 0.0184586 0.0184586
Toxoplasma gondii histone deacetylase HDAC2 0.0231283 0.067212 0.194587
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0930775 0.302524 0.383888
Echinococcus multilocularis nardilysin 0.00352699 0.00127221 0.00127221
Echinococcus multilocularis rhodopsin orphan GPCR 0.0930775 0.302524 0.302524
Echinococcus granulosus nuclear receptor co repressor related ncor 0.0333333 0.101542 0.101542
Echinococcus granulosus neuroendocrine convertase 2 0.0455026 0.14248 0.14248
Echinococcus granulosus tyrosine protein kinase HCK 0.00704164 0.0130957 0.0130957
Brugia malayi hypothetical protein 0.0930775 0.302524 0.399699
Loa Loa (eye worm) TK/INSR protein kinase 0.0101288 0.0234809 0.0610504
Schistosoma mansoni memapsin-2 (A01 family) 0.00454365 0.00469231 0.00595431
Onchocerca volvulus 0.00444421 0.00435776 0.0143854
Loa Loa (eye worm) animal heme peroxidase 0.00767733 0.0152341 0.0396089
Brugia malayi endoprotease bli-4 precursor 0.0729523 0.234822 0.31025
Loa Loa (eye worm) hypothetical protein 0.00444421 0.00435776 0.0113302
Echinococcus granulosus sodium and chloride dependent glycine 0.00444421 0.00435776 0.00435776
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Onchocerca volvulus Peroxidase homolog 0.00767733 0.0152341 0.0503382
Echinococcus multilocularis cathepsin l cysteine peptidase 0.00732058 0.014034 0.014034
Echinococcus multilocularis orexin receptor type 2 0.0930775 0.302524 0.302524
Echinococcus multilocularis g protein coupled receptor 0.0930775 0.302524 0.302524
Loa Loa (eye worm) hypothetical protein 0.00444421 0.00435776 0.0113302
Loa Loa (eye worm) hypothetical protein 0.102173 0.333123 0.866122
Giardia lamblia Beta tubulin 0.105208 0.34333 1
Brugia malayi proprotein convertase 2 0.0455026 0.14248 0.188247
Plasmodium falciparum cysteine proteinase falcipain 2a 0.00732058 0.014034 0.0312854
Leishmania major cathepsin L-like protease 0.00732058 0.014034 0.0373089
Entamoeba histolytica cysteine protease, putative 0.00732058 0.014034 0.0312854
Brugia malayi Animal haem peroxidase family protein 0.00767733 0.0152341 0.0201276
Brugia malayi Melatonin receptor type 1A 0.0930775 0.302524 0.399699
Loa Loa (eye worm) ctsf protein 0.00732058 0.014034 0.0364886
Schistosoma mansoni tyrosine kinase 0.0101904 0.0236884 0.0300594
Onchocerca volvulus 0.0930775 0.302524 1
Echinococcus multilocularis c src tyrosine kinase 0.00867608 0.018594 0.018594
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.010361 0.0242621 0.0242621
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0930775 0.302524 0.302524
Trichomonas vaginalis conserved hypothetical protein 0.0142889 0.0374758 0.100246
Brugia malayi Protein kinase domain containing protein 0.0101288 0.0234809 0.0310233
Onchocerca volvulus Cathepsin L homolog 0.00732058 0.014034 0.0463711
Echinococcus granulosus uncharacterized sodium dependent transporter 0.00444421 0.00435776 0.00435776
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0930775 0.302524 1
Schistosoma mansoni tubulin subunit beta 0.105208 0.34333 0.435669
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0930775 0.302524 0.383888
Loa Loa (eye worm) matrixin family protein 0.00527779 0.00716198 0.0186212
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.00444421 0.00435776 0.00552978
Brugia malayi map kinase activated protein kinase protein 2 0.0201104 0.0570597 0.075388
Plasmodium vivax histone deacetylase, putative 0.00994152 0.022851 0.0572229
Plasmodium falciparum plasmepsin VI 0.0192184 0.0540589 0.14903
Echinococcus granulosus g protein coupled receptor 0.0930775 0.302524 0.302524
Trichomonas vaginalis tubulin beta chain, putative 0.105208 0.34333 1
Schistosoma mansoni biogenic amine receptor 0.0930775 0.302524 0.383888
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.00793631 0.0161054 0.0161054
Echinococcus multilocularis dnaJ subfamily B 0.237407 0.788053 0.788053
Schistosoma mansoni hypothetical protein 0.0930775 0.302524 0.383888
Loa Loa (eye worm) hypothetical protein 0.00454365 0.00469231 0.0122001
Brugia malayi Furin-like cysteine rich region family protein 0.0305989 0.0923432 0.122005
Echinococcus granulosus tyrosine protein kinase Lyn 0.0102351 0.0238387 0.0238387
Loa Loa (eye worm) TYRA-2 protein 0.0930775 0.302524 0.786565
Brugia malayi ephrin receptor 1 precursor 0.00359448 0.00149923 0.00198081
Schistosoma mansoni neuropeptide receptor 0.0930775 0.302524 0.383888
Echinococcus multilocularis ephrin type A receptor 4 A 0.0068572 0.0124752 0.0124752
Plasmodium falciparum plasmepsin V 0.00454365 0.00469231 0.00380416
Loa Loa (eye worm) animal heme peroxidase 0.00767733 0.0152341 0.0396089
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0930775 0.302524 0.383888
Trichomonas vaginalis tubulin epsilon chain, putative 0.105208 0.34333 1
Onchocerca volvulus Matrilysin homolog 0.00484132 0.00569366 0.0188013
Loa Loa (eye worm) aspartic protease BmAsp-1 0.00454365 0.00469231 0.0122001
Loa Loa (eye worm) hypothetical protein 0.00969344 0.0220164 0.0572429
Onchocerca volvulus 0.0703174 0.225958 0.746905
Onchocerca volvulus 0.0930775 0.302524 1
Echinococcus granulosus neuropeptide receptor 0.0930775 0.302524 0.302524
Plasmodium vivax histone deacetylase, putative 0.0208259 0.0594664 0.164937
Onchocerca volvulus Dual oxidase homolog 0.00767733 0.0152341 0.0503382
Echinococcus granulosus rhodopsin orphan GPCR 0.0930775 0.302524 0.302524
Entamoeba histolytica tubulin family protein 0.105208 0.34333 1
Leishmania major cathepsin L-like protease 0.00732058 0.014034 0.0373089
Schistosoma mansoni neuropeptide receptor 0.0930775 0.302524 0.383888
Trichomonas vaginalis conserved hypothetical protein 0.0142889 0.0374758 0.100246
Loa Loa (eye worm) hypothetical protein 0.00444421 0.00435776 0.0113302
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0101904 0.0236884 0.0236884
Schistosoma mansoni cathepsin D (A01 family) 0.0566644 0.180029 0.228448
Trichomonas vaginalis histone deacetylase, putative 0.0231283 0.067212 0.187723
Echinococcus multilocularis Tubulin beta 2C chain 0.105208 0.34333 0.34333
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0930775 0.302524 0.786565
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.00444421 0.00435776 0.00552978
Loa Loa (eye worm) hypothetical protein 0.0117371 0.0288913 0.0751176
Echinococcus multilocularis 0.0586634 0.186754 0.186754
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Echinococcus granulosus epidermal growth factor receptor 0.0166792 0.0455168 0.0455168
Echinococcus granulosus histone deacetylase 6 0.0208259 0.0594664 0.0594664
Brugia malayi Cathepsin L-like precursor 0.00516513 0.00678298 0.00896178
Trichomonas vaginalis conserved hypothetical protein 0.0142889 0.0374758 0.100246
Giardia lamblia Histone deacetylase 0.0231283 0.067212 0.137803
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.00383521 0.00230907 0.00230907
Giardia lamblia Beta tubulin 0.105208 0.34333 1
Loa Loa (eye worm) hypothetical protein 0.0231283 0.067212 0.174752
Leishmania major cathepsin L-like protease 0.00732058 0.014034 0.0373089
Plasmodium falciparum amino acid transporter, putative 0.00444421 0.00435776 0.00281999
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.00415925 0.00339916 0.00431337
Loa Loa (eye worm) histone deacetylase 1 0.0231283 0.067212 0.174752
Brugia malayi putative neuropeptide receptor 0.0930775 0.302524 0.399699
Brugia malayi neuroendocrine convertase 1 precursor 0.0455026 0.14248 0.188247
Trypanosoma brucei histone deacetylase 2 0.00994152 0.022851 0.0630851
Brugia malayi Sodium:neurotransmitter symporter family protein 0.00444421 0.00435776 0.00575754
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.00444421 0.00435776 0.00552978
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0439776 0.13735 0.13735
Entamoeba histolytica protein kinase, putative 0.00704164 0.0130957 0.0285249
Echinococcus granulosus tyrosine protein kinase Src64B 0.0101904 0.0236884 0.0236884
Schistosoma mansoni insulysin unit 3 (M16 family) 0.00352699 0.00127221 0.00161437
Echinococcus granulosus biogenic amine 5HT receptor 0.102173 0.333123 0.333123
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0930775 0.302524 0.786565
Brugia malayi Cathepsin L-like precursor 0.00516513 0.00678298 0.00896178
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Loa Loa (eye worm) animal heme peroxidase 0.00767733 0.0152341 0.0396089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00732058 0.014034 0.0312854
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0231283 0.067212 0.187723
Echinococcus granulosus rhodopsin orphan GPCR 0.0930775 0.302524 0.302524
Brugia malayi hypothetical protein 0.0930775 0.302524 0.399699
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0930775 0.302524 0.383888
Echinococcus multilocularis tyrosine protein kinase csk 0.00552727 0.00800125 0.00800125
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Echinococcus granulosus 7TM GPCR rhodopsin 0.0930775 0.302524 0.302524
Echinococcus granulosus sex peptide receptor 0.0930775 0.302524 0.302524
Onchocerca volvulus 0.0703174 0.225958 0.746905
Trichomonas vaginalis conserved hypothetical protein 0.0142889 0.0374758 0.100246
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.180847 0.597786 0.597786
Leishmania major beta tubulin 0.105208 0.34333 1
Echinococcus granulosus peroxidasin 0.00767733 0.0152341 0.0152341
Trypanosoma cruzi histone deacetylase, putative 0.0208259 0.0594664 0.17013
Onchocerca volvulus 0.00712146 0.0133642 0.0441568
Brugia malayi Dopamine receptor 0.0930775 0.302524 0.399699
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0166792 0.0455168 0.0455168
Onchocerca volvulus 0.0930775 0.302524 1
Plasmodium vivax aspartyl proteinase, putative 0.00454365 0.00469231 0.00380416
Onchocerca volvulus 0.0930775 0.302524 1
Plasmodium vivax plasmepsin V, putative 0.00454365 0.00469231 0.00380416
Toxoplasma gondii beta tubulin 0.105208 0.34333 1
Schistosoma mansoni peroxidasin 0.00767733 0.0152341 0.0193314
Loa Loa (eye worm) hypothetical protein 0.0443903 0.138738 0.36072
Schistosoma mansoni tubulin subunit beta 0.105208 0.34333 0.435669
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0930775 0.302524 0.302524
Onchocerca volvulus Matrix metalloproteinase homolog 0.00484132 0.00569366 0.0188013
Toxoplasma gondii beta-1 tubulin, putative 0.105208 0.34333 1
Loa Loa (eye worm) hypothetical protein 0.102173 0.333123 0.866122
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.00444421 0.00435776 0.0112459
Echinococcus multilocularis neuropeptides capa receptor 0.0930775 0.302524 0.302524
Brugia malayi hypothetical protein 0.0930775 0.302524 0.399699
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.00444421 0.00435776 0.00435776
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Loa Loa (eye worm) blistered cuticle protein 3 0.00767733 0.0152341 0.0396089
Leishmania major beta tubulin 0.105208 0.34333 1
Plasmodium vivax glutathione reductase, putative 0.00761339 0.015019 0.0341831
Trypanosoma brucei histone deacetylase 3 0.0208259 0.0594664 0.17013
Brugia malayi Serotonin receptor 0.0930775 0.302524 0.399699
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0100098 0.0230807 0.0637568
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00732058 0.014034 0.0312854
Plasmodium falciparum transporter, putative 0.00444421 0.00435776 0.00281999
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Brugia malayi SRC-1 0.0101904 0.0236884 0.0312974
Schistosoma mansoni tyrosine kinase 0.00867608 0.018594 0.0235948
Echinococcus multilocularis rhodopsin orphan GPCR 0.0930775 0.302524 0.302524
Echinococcus multilocularis histone deacetylase 6 0.0216786 0.062335 0.062335
Echinococcus multilocularis histone deacetylase 6 0.0208259 0.0594664 0.0594664
Loa Loa (eye worm) hypothetical protein 0.00767733 0.0152341 0.0396089
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0930775 0.302524 0.383888
Echinococcus multilocularis histone deacetylase 1 0.0231283 0.067212 0.067212
Loa Loa (eye worm) hypothetical protein 0.11748 0.384614 1
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Echinococcus granulosus 7tm_1 domain containing protein 0.0930775 0.302524 0.302524
Brugia malayi hypothetical protein 0.0930775 0.302524 0.399699
Onchocerca volvulus 0.0930775 0.302524 1
Brugia malayi hypothetical protein 0.00454365 0.00469231 0.00619955
Echinococcus multilocularis tyrosine protein kinase csk 0.00552727 0.00800125 0.00800125
Schistosoma mansoni amine GPCR 0.0930775 0.302524 0.383888
Schistosoma mansoni furin-1 (S08 family) 0.0312137 0.0944114 0.119803
Echinococcus granulosus furin 0.0729523 0.234822 0.234822
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0192184 0.0540589 0.14903
Leishmania major beta tubulin 0.105208 0.34333 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0930775 0.302524 0.302524
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00732058 0.014034 0.0312854
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.00444421 0.00435776 0.0112459
Echinococcus multilocularis fmrfamide receptor 0.0930775 0.302524 0.302524
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00732058 0.014034 0.0312854
Brugia malayi neuropeptide F receptor 0.0930775 0.302524 0.399699
Echinococcus multilocularis histone deacetylase 7 0.0208259 0.0594664 0.0594664
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0930775 0.302524 0.302524
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0930775 0.302524 0.786565
Onchocerca volvulus 0.00732058 0.014034 0.0463711
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0930775 0.302524 0.383888
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0101904 0.0236884 0.0236884
Brugia malayi LBP/BPI 0.0259271 0.0766272 0.101241
Onchocerca volvulus 0.00454365 0.00469231 0.0154912
Loa Loa (eye worm) hypothetical protein 0.00444421 0.00435776 0.0113302
Plasmodium vivax aspartyl protease, putative 0.00454365 0.00469231 0.00380416
Brugia malayi sulfakinin receptor protein 0.0930775 0.302524 0.399699
Schistosoma mansoni tubulin subunit beta 0.105208 0.34333 0.435669
Loa Loa (eye worm) hypothetical protein 0.00516513 0.00678298 0.0176358
Schistosoma mansoni tyrosine kinase 0.0101288 0.0234809 0.029796
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.00444421 0.00435776 0.00435776
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0443903 0.138738 0.183303
Schistosoma mansoni histone deacetylase 4 5 0.0208259 0.0594664 0.0754599
Loa Loa (eye worm) hypothetical protein 0.0443903 0.138738 0.36072
Brugia malayi neuropeptide F receptor 0.0930775 0.302524 0.399699
Echinococcus granulosus tyrosine protein kinase Fyn 0.0101904 0.0236884 0.0236884
Echinococcus multilocularis tyrosine protein kinase HCK 0.00704164 0.0130957 0.0130957
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00732058 0.014034 0.0312854
Brugia malayi Animal haem peroxidase family protein 0.00767733 0.0152341 0.0201276
Echinococcus granulosus tachykinin peptides receptor 99D 0.109217 0.356819 0.356819
Leishmania major cathepsin L-like protease 0.00732058 0.014034 0.0373089
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.021476 0.0616536 0.0782353
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Loa Loa (eye worm) hypothetical protein 0.021476 0.0616536 0.1603
Plasmodium vivax aspartyl protease, putative 0.00454365 0.00469231 0.00380416
Toxoplasma gondii aspartyl protease 0.00454365 0.00469231 0.0122217
Echinococcus granulosus histone deacetylase 0.0208259 0.0594664 0.0594664
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0930775 0.302524 0.383888
Onchocerca volvulus 0.00732058 0.014034 0.0463711
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.00444421 0.00435776 0.0112459
Loa Loa (eye worm) hypothetical protein 0.0061708 0.0101661 0.026432
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0930775 0.302524 0.302524
Loa Loa (eye worm) G-protein coupled receptor 0.0930775 0.302524 0.786565
Echinococcus granulosus tyrosine protein kinase Fyn 0.0101904 0.0236884 0.0236884
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00732058 0.014034 0.0373089
Schistosoma mansoni serine/threonine protein kinase 0.0201104 0.0570597 0.0724058
Brugia malayi Cathepsin L-like precursor 0.00732058 0.014034 0.018542
Giardia lamblia Furin precursor putative serine protease 0.0142889 0.0374758 0.0449495
Schistosoma mansoni neuropeptide receptor 0.107945 0.352538 0.447352
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0930775 0.302524 0.383888
Loa Loa (eye worm) hypothetical protein 0.00767733 0.0152341 0.0396089
Echinococcus multilocularis thioredoxin glutathione reductase 0.00761339 0.015019 0.015019
Loa Loa (eye worm) hypothetical protein 0.0259271 0.0766272 0.199231
Loa Loa (eye worm) hypothetical protein 0.0261804 0.0774793 0.201447
Echinococcus granulosus histone deacetylase 6 0.0216786 0.062335 0.062335
Trypanosoma cruzi histone deacetylase, putative 0.00994152 0.022851 0.0630851
Trypanosoma cruzi histone deacetylase, putative 0.0208259 0.0594664 0.17013
Leishmania major cathepsin L-like protease 0.00732058 0.014034 0.0373089
Trichomonas vaginalis hypothetical protein 0.0142889 0.0374758 0.100246
Plasmodium vivax hypothetical protein, conserved 0.00444421 0.00435776 0.00281999
Plasmodium vivax plasmepsin IV, putative 0.0192184 0.0540589 0.14903
Toxoplasma gondii thioredoxin reductase 0.00761339 0.015019 0.0423439
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00732058 0.014034 0.0312854
Plasmodium falciparum tubulin beta chain 0.105208 0.34333 1
Echinococcus multilocularis neuropeptide receptor 0.0930775 0.302524 0.302524
Plasmodium falciparum plasmepsin IX 0.00454365 0.00469231 0.00380416
Brugia malayi Histone deacetylase 1 0.0231283 0.067212 0.0888015
Brugia malayi hypothetical protein 0.0930775 0.302524 0.399699
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00732058 0.014034 0.0312854
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0165279 0.0450077 0.122403
Echinococcus granulosus peptide allatostatin:somatostatin 0.0930775 0.302524 0.302524
Echinococcus granulosus tyrosine protein kinase csk 0.00552727 0.00800125 0.00800125
Echinococcus granulosus histone deacetylase 1 0.0231283 0.067212 0.067212
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00732058 0.014034 0.0312854
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Toxoplasma gondii aspartyl protease ASP1 0.0192184 0.0540589 0.15622
Schistosoma mansoni histamine h1 receptor 0.0930775 0.302524 0.383888
Echinococcus granulosus cathepsin b 0.021476 0.0616536 0.0616536
Schistosoma mansoni histone deacetylase 0.0231283 0.067212 0.0852887
Leishmania major cysteine peptidase A (CPA) 0.00732058 0.014034 0.0373089
Echinococcus multilocularis cathepsin b 0.021476 0.0616536 0.0616536
Brugia malayi insulin-degrading enzyme 0.00352699 0.00127221 0.00168086
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Loa Loa (eye worm) hypothetical protein 0.0443903 0.138738 0.36072
Plasmodium vivax tubulin beta chain, putative 0.105208 0.34333 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00732058 0.014034 0.0373089
Echinococcus granulosus fmrfamide receptor 0.0930775 0.302524 0.302524
Echinococcus granulosus cathepsin L cysteine protease 0.00415925 0.00339916 0.00339916
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0930775 0.302524 0.383888
Echinococcus granulosus g protein coupled receptor 0.0930775 0.302524 0.302524
Schistosoma mansoni hypothetical protein 0.0930775 0.302524 0.383888
Onchocerca volvulus 0.0930775 0.302524 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0101904 0.0236884 0.0236884
Echinococcus multilocularis peroxidasin 0.00767733 0.0152341 0.0152341
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0930775 0.302524 0.383888
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00732058 0.014034 0.0312854
Echinococcus multilocularis Tubulin beta 2C chain 0.105208 0.34333 0.34333
Schistosoma mansoni tyrosine kinase 0.00383521 0.00230907 0.00293009
Onchocerca volvulus 0.0703174 0.225958 0.746905
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0930775 0.302524 0.302524
Schistosoma mansoni amine GPCR 0.0930775 0.302524 0.383888
Leishmania major beta tubulin 0.105208 0.34333 1
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Trypanosoma cruzi beta tubulin, putative 0.105208 0.34333 1
Onchocerca volvulus 0.0703174 0.225958 0.746905
Onchocerca volvulus 0.0930775 0.302524 1
Echinococcus granulosus Tubulin beta 2C chain 0.105208 0.34333 0.34333
Loa Loa (eye worm) hypothetical protein 0.0729523 0.234822 0.610539
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00732058 0.014034 0.0312854
Onchocerca volvulus 0.0930775 0.302524 1
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.00444421 0.00435776 0.00575754
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.00444421 0.00435776 0.0113302
Loa Loa (eye worm) SH2 domain-containing protein 0.00643507 0.0110551 0.0287434
Brugia malayi larval opioid receptor 0.0930775 0.302524 0.399699
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.00732058 0.014034 0.0312854
Loa Loa (eye worm) neuropeptide F receptor 0.0930775 0.302524 0.786565
Leishmania major beta tubulin 0.105208 0.34333 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0930775 0.302524 0.302524
Schistosoma mansoni histone deacetylase 0.0231283 0.067212 0.0852887
Echinococcus granulosus tyrosine protein kinase Blk 0.00863583 0.0184586 0.0184586
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.021476 0.0616536 0.0782353
Echinococcus multilocularis insulin degrading enzyme 0.00352699 0.00127221 0.00127221
Onchocerca volvulus 0.0261804 0.0774793 0.256095
Loa Loa (eye worm) G-protein coupled receptor 0.0930775 0.302524 0.786565
Brugia malayi Sodium:neurotransmitter symporter family protein 0.00444421 0.00435776 0.00575754
Brugia malayi Dopamine receptor protein 1 0.0930775 0.302524 0.399699
Trypanosoma cruzi histone deacetylase, putative 0.00994152 0.022851 0.0630851
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00732058 0.014034 0.0312854
Loa Loa (eye worm) melatonin receptor type 1A 0.0930775 0.302524 0.786565
Brugia malayi G-protein coupled receptor 0.0930775 0.302524 0.399699
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.00454365 0.00469231 0.0122217
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00732058 0.014034 0.0373089
Loa Loa (eye worm) hypothetical protein 0.0261804 0.0774793 0.201447
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0231283 0.067212 0.187723
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.00732058 0.014034 0.0312854
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00415925 0.00339916 0.00621811
Echinococcus multilocularis somatostatin receptor 0.0930775 0.302524 0.302524
Brugia malayi Papain family cysteine protease containing protein 0.00415925 0.00339916 0.00449102
Loa Loa (eye worm) hypothetical protein 0.00994152 0.022851 0.0594127
Echinococcus multilocularis tyrosine protein kinase Src42A 0.00794944 0.0161495 0.0161495
Echinococcus multilocularis beta tubulin 0.105208 0.34333 0.34333
Schistosoma mansoni hypothetical protein 0.0930775 0.302524 0.383888
Plasmodium falciparum thioredoxin reductase 0.00761339 0.015019 0.0341831
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0192184 0.0540589 0.140554
Echinococcus multilocularis serotonin receptor 0.102173 0.333123 0.333123
Echinococcus multilocularis rhodopsin orphan GPCR 0.0930775 0.302524 0.302524
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0231283 0.067212 0.187723
Trypanosoma cruzi cysteine protease, putative 0.00415925 0.00339916 0.00621811
Plasmodium vivax histone deacetylase 2, putative 0.0208259 0.0594664 0.164937
Brugia malayi hypothetical protein 0.0930775 0.302524 0.399699
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00732058 0.014034 0.0312854
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00454365 0.00469231 0.00595431
Trichomonas vaginalis histone deacetylase, putative 0.0231283 0.067212 0.187723
Brugia malayi hypothetical protein 0.0443903 0.138738 0.183303
Loa Loa (eye worm) beta-tubulin 0.105208 0.34333 0.892661
Schistosoma mansoni opsin-like receptor 0.0930775 0.302524 0.383888
Echinococcus multilocularis allatostatin A receptor 0.0930775 0.302524 0.302524
Leishmania major beta tubulin 0.105208 0.34333 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0930775 0.302524 0.302524
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00454365 0.00469231 0.00595431
Echinococcus multilocularis epidermal growth factor receptor 0.0305989 0.0923432 0.0923432
Loa Loa (eye worm) thioredoxin reductase 0.00761339 0.015019 0.0390496
Leishmania major histone deacetylase, putative 0.0208259 0.0594664 0.17013
Echinococcus granulosus thioredoxin glutathione reductase 0.00761339 0.015019 0.015019
Echinococcus granulosus neuropeptide receptor A26 0.0930775 0.302524 0.302524
Echinococcus granulosus tm gpcr rhodopsin 0.0930775 0.302524 0.302524
Echinococcus multilocularis histone deacetylase 0.0208259 0.0594664 0.0594664
Trypanosoma cruzi cysteine peptidase, putative 0.00732058 0.014034 0.0373089
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.021476 0.0616536 0.0782353
Echinococcus granulosus neuropeptide Y receptor 0.0930775 0.302524 0.302524
Onchocerca volvulus Peroxidasin homolog 0.00767733 0.0152341 0.0503382
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0192184 0.0540589 0.068598
Onchocerca volvulus Cathepsin L homolog 0.00732058 0.014034 0.0463711
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.00444421 0.00435776 0.00552978
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Onchocerca volvulus 0.00767733 0.0152341 0.0503382
Plasmodium vivax thioredoxin reductase, putative 0.00761339 0.015019 0.0341831
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0165279 0.0450077 0.122403
Echinococcus multilocularis sodium and chloride dependent glycine 0.00444421 0.00435776 0.00435776
Echinococcus multilocularis Tubulin beta 2C chain 0.105208 0.34333 0.34333
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00732058 0.014034 0.0312854
Loa Loa (eye worm) solute carrier family 6 member 4 0.0261804 0.0774793 0.201447
Schistosoma mansoni nardilysin (M16 family) 0.00352699 0.00127221 0.00161437
Trichomonas vaginalis tubulin, putative 0.105208 0.34333 1
Brugia malayi Cathepsin L-like precursor 0.00732058 0.014034 0.018542
Echinococcus granulosus cathepsin b 0.021476 0.0616536 0.0616536
Onchocerca volvulus 0.00732058 0.014034 0.0463711
Echinococcus multilocularis g-protein coupled receptor 0.0930775 0.302524 0.302524
Echinococcus multilocularis cathepsin L cysteine protease 0.00732058 0.014034 0.014034
Echinococcus multilocularis tyrosine protein kinase Fyn 0.00863583 0.0184586 0.0184586
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0439776 0.13735 0.13735
Brugia malayi Tyrosine-protein kinase abl-1 0.0145498 0.0383536 0.0506733
Schistosoma mansoni hypothetical protein 0.237407 0.788053 1
Onchocerca volvulus Histone deacetylase 10 homolog 0.00994152 0.022851 0.0755163
Schistosoma mansoni tyrosine kinase 0.0166792 0.0455168 0.0577585
Entamoeba histolytica histone deacetylase, putative 0.0231283 0.067212 0.187723
Echinococcus multilocularis Tubulin beta 2C chain 0.105208 0.34333 0.34333
Brugia malayi Serotonin receptor 0.141839 0.466559 0.616424
Echinococcus multilocularis sodium and chloride dependent glycine 0.00444421 0.00435776 0.00435776
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00732058 0.014034 0.0373089
Brugia malayi RE15519p 0.0930775 0.302524 0.399699
Loa Loa (eye worm) papain family cysteine protease containing protein 0.00732058 0.014034 0.0364886
Echinococcus multilocularis cathepsin L cysteine protease 0.00732058 0.014034 0.014034
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0201104 0.0570597 0.0570597
Loa Loa (eye worm) hypothetical protein 0.0261804 0.0774793 0.201447
Echinococcus multilocularis cysteine protease 0.00732058 0.014034 0.014034
Brugia malayi histone deacetylase 11 0.00994152 0.022851 0.030191
Echinococcus multilocularis neuroendocrine convertase 2 0.0455026 0.14248 0.14248
Trichomonas vaginalis tubulin alpha chain, putative 0.105208 0.34333 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00732058 0.014034 0.0373089
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.00444421 0.00435776 0.00435776
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.00444421 0.00435776 0.00435776
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0703174 0.225958 0.298539
Schistosoma mansoni tyrosine kinase 0.0101288 0.0234809 0.029796
Echinococcus granulosus neuropeptide Y receptor 0.0930775 0.302524 0.302524
Echinococcus granulosus Furin 1 0.0165279 0.0450077 0.0450077
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0165279 0.0450077 0.0571125
Brugia malayi glutathione reductase 0.00761339 0.015019 0.0198434
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0703174 0.225958 0.298539
Onchocerca volvulus 0.0930775 0.302524 1
Echinococcus granulosus g protein coupled receptor 0.0930775 0.302524 0.302524
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0261804 0.0774793 0.0983174
Trypanosoma cruzi cysteine peptidase, putative 0.00415925 0.00339916 0.00621811
Echinococcus granulosus insulin degrading enzyme 0.00352699 0.00127221 0.00127221
Echinococcus granulosus tyrosine protein kinase Src42A 0.0101904 0.0236884 0.0236884
Echinococcus multilocularis epidermal growth factor receptor 0.0166792 0.0455168 0.0455168
Trichomonas vaginalis conserved hypothetical protein 0.0142889 0.0374758 0.100246
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0930775 0.302524 0.399699
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0443903 0.138738 0.36072
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00454365 0.00469231 0.00595431
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Brugia malayi hypothetical protein 0.00444421 0.00435776 0.00575754
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.00444421 0.00435776 0.00552978
Echinococcus granulosus tyrosine kinase 0.00863583 0.0184586 0.0184586
Loa Loa (eye worm) animal heme peroxidase 0.00767733 0.0152341 0.0396089
Schistosoma mansoni cathepsin F (C01 family) 0.00516513 0.00678298 0.00860727
Brugia malayi Thioredoxin reductase 0.00761339 0.015019 0.0198434
Echinococcus multilocularis 0.00931136 0.0207311 0.0207311
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00732058 0.014034 0.0312854
Echinococcus granulosus rhodopsin orphan GPCR 0.0930775 0.302524 0.302524
Toxoplasma gondii sporozoite developmental protein 0.00352699 0.00127221 0.00224556
Brugia malayi hypothetical protein 0.0930775 0.302524 0.399699
Plasmodium falciparum histone deacetylase, putative 0.0208259 0.0594664 0.164937
Loa Loa (eye worm) hypothetical protein 0.0192184 0.0540589 0.140554
Plasmodium falciparum histone deacetylase 2 0.0208259 0.0594664 0.164937
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0101904 0.0236884 0.0236884
Brugia malayi Tubulin beta-1 chain 0.105208 0.34333 0.453613
Trichomonas vaginalis conserved hypothetical protein 0.0142889 0.0374758 0.100246
Loa Loa (eye worm) hypothetical protein 0.0289747 0.0868795 0.225887
Echinococcus granulosus histone deacetylase 7 0.0208259 0.0594664 0.0594664
Echinococcus granulosus uncharacterized sodium dependent transporter 0.00444421 0.00435776 0.00435776
Echinococcus multilocularis neuropeptide receptor 0.107945 0.352538 0.352538
Brugia malayi AKH receptor 0.0930775 0.302524 0.399699
Leishmania major beta tubulin 0.105208 0.34333 1
Onchocerca volvulus 0.0703174 0.225958 0.746905
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0443903 0.138738 0.36072
Plasmodium falciparum plasmepsin IV 0.0192184 0.0540589 0.14903
Onchocerca volvulus 0.00444421 0.00435776 0.0143854
Schistosoma mansoni neuropeptide f receptor 76f 0.0930775 0.302524 0.383888
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0101904 0.0236884 0.0236884
Trypanosoma cruzi cysteine peptidase, putative 0.00732058 0.014034 0.0373089
Echinococcus granulosus cathepsin l1 0.00732058 0.014034 0.014034
Schistosoma mansoni tyrosine kinase 0.0305989 0.0923432 0.117179
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Brugia malayi G protein-coupled receptor 0.0930775 0.302524 0.399699
Schistosoma mansoni ephrin receptor 0.0068572 0.0124752 0.0158304
Brugia malayi SH2 domain containing protein 0.00712146 0.0133642 0.017657
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0192184 0.0540589 0.0540589
Trypanosoma brucei histone deacetylase 4 0.0208259 0.0594664 0.17013
Echinococcus multilocularis tyrosine protein kinase Srms 0.00863583 0.0184586 0.0184586
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0930775 0.302524 0.302524
Giardia lamblia Beta tubulin 0.105208 0.34333 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.00444421 0.00435776 0.00575754
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0100098 0.0230807 0.0292883
Echinococcus multilocularis neuropeptide Y receptor 0.0930775 0.302524 0.302524
Loa Loa (eye worm) hypothetical protein 0.00444421 0.00435776 0.0113302
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.021476 0.0616536 0.176524
Echinococcus granulosus cathepsin l cysteine peptidase 0.00732058 0.014034 0.014034
Echinococcus multilocularis fmrfamide receptor 0.0930775 0.302524 0.302524
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0439776 0.13735 0.394053
Trichomonas vaginalis conserved hypothetical protein 0.0142889 0.0374758 0.100246
Echinococcus multilocularis Tubulin beta 2C chain 0.105208 0.34333 0.34333
Brugia malayi Pepsin A precursor 0.00454365 0.00469231 0.00619955
Loa Loa (eye worm) hypothetical protein 0.00767733 0.0152341 0.0396089
Echinococcus granulosus alpha 1A adrenergic receptor 0.0930775 0.302524 0.302524
Loa Loa (eye worm) SRC-1 0.0101904 0.0236884 0.06159
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.00415925 0.00339916 0.00431337
Echinococcus multilocularis Furin 1 0.0165279 0.0450077 0.0450077
Schistosoma mansoni cathepsin F (C01 family) 0.00732058 0.014034 0.0178085
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Schistosoma mansoni myosin xvIII 0.0930775 0.302524 0.383888
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Trypanosoma cruzi histone deacetylase, putative 0.0208259 0.0594664 0.17013
Brugia malayi celfurPC protein 0.0586634 0.186754 0.246742
Leishmania major cathepsin L-like protease 0.00732058 0.014034 0.0373089
Brugia malayi putative neuropeptide receptor NPR1 0.0930775 0.302524 0.399699
Schistosoma mansoni insulysin unit 3 (M16 family) 0.00352699 0.00127221 0.00161437
Leishmania major beta tubulin 0.105208 0.34333 1
Echinococcus granulosus tubulin beta 4A class IVa 0.105208 0.34333 0.34333
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0165279 0.0450077 0.122403
Loa Loa (eye worm) endoprotease bli-4 0.0729523 0.234822 0.610539
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0192184 0.0540589 0.0540589
Trichomonas vaginalis histone deacetylase, putative 0.0231283 0.067212 0.187723
Schistosoma mansoni histone deacetylase hda2 0.00994152 0.022851 0.0289967
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0930775 0.302524 0.786565
Plasmodium vivax amine transporter, putative 0.00444421 0.00435776 0.00281999
Loa Loa (eye worm) hypothetical protein 0.00767733 0.0152341 0.0396089
Plasmodium vivax aspartyl proteinase, putative 0.0192184 0.0540589 0.14903
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00454365 0.00469231 0.00595431
Trypanosoma brucei beta tubulin 0.105208 0.34333 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00415925 0.00339916 0.00621811
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.00863583 0.0184586 0.0184586
Brugia malayi G protein-coupled receptor F59B2.13 0.0930775 0.302524 0.399699
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.00383521 0.00230907 0.00293009
Echinococcus granulosus g-protein coupled receptor 0.0930775 0.302524 0.302524
Trichomonas vaginalis tubulin epsilon chain, putative 0.105208 0.34333 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0101904 0.0236884 0.0236884
Loa Loa (eye worm) serotonin transporter b 0.0261804 0.0774793 0.201447
Echinococcus granulosus cysteine protease 0.00415925 0.00339916 0.00339916
Echinococcus granulosus somatostatin receptor 0.0930775 0.302524 0.302524
Echinococcus multilocularis cathepsin l cysteine peptidase 0.00732058 0.014034 0.014034
Brugia malayi Tachykinin-like peptides receptor 99D 0.111394 0.364141 0.481108
Brugia malayi Calcium binding EGF domain containing protein 0.00315057 0.00000593077 0.00000783581
Brugia malayi Animal haem peroxidase family protein 0.00767733 0.0152341 0.0201276
Onchocerca volvulus 0.00732058 0.014034 0.0463711
Echinococcus multilocularis nardilysin 0.00352699 0.00127221 0.00127221
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Onchocerca volvulus Peroxidasin homolog 0.00767733 0.0152341 0.0503382
Brugia malayi histone deacetylase 1 (HD1) 0.0231283 0.067212 0.0888015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0930775 0.302524 0.383888
Schistosoma mansoni biogenic amine (5HT) receptor 0.132063 0.433672 0.550308
Echinococcus multilocularis tachykinin peptides receptor 99D 0.109217 0.356819 0.356819
Schistosoma mansoni hypothetical protein 0.0142889 0.0374758 0.0475549
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.00444421 0.00435776 0.00552978
Plasmodium falciparum histone deacetylase 1 0.0231283 0.067212 0.187723
Loa Loa (eye worm) hypothetical protein 0.0703174 0.225958 0.587493
Schistosoma mansoni tyrosine kinase 0.0159928 0.0432077 0.0548285
Schistosoma mansoni cathepsin D (A01 family) 0.0566644 0.180029 0.228448
Echinococcus granulosus tyrosine protein kinase Fyn 0.0101904 0.0236884 0.0236884
Plasmodium falciparum cysteine proteinase falcipain 2b 0.00732058 0.014034 0.0312854
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0930775 0.302524 0.399699
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0101904 0.0236884 0.0236884
Onchocerca volvulus 0.0930775 0.302524 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.00415925 0.00339916 0.00431337
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00732058 0.014034 0.0312854
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00732058 0.014034 0.0312854
Brugia malayi Cathepsin L-like precursor 0.00732058 0.014034 0.018542
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0703174 0.225958 0.587493
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00454365 0.00469231 0.00595431
Brugia malayi Animal haem peroxidase family protein 0.00767733 0.0152341 0.0201276
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0930775 0.302524 0.302524
Leishmania major beta tubulin 0.105208 0.34333 1
Loa Loa (eye worm) hypothetical protein 0.0259271 0.0766272 0.199231
Onchocerca volvulus Peroxidase homolog 0.00767733 0.0152341 0.0503382
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.00444421 0.00435776 0.00552978
Loa Loa (eye worm) glutathione reductase 0.00761339 0.015019 0.0390496
Loa Loa (eye worm) matrixin family protein 0.00484132 0.00569366 0.0148036
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Echinococcus multilocularis neuropeptide s receptor 0.0930775 0.302524 0.302524
Echinococcus granulosus orexin receptor type 2 0.0930775 0.302524 0.302524
Entamoeba histolytica tubulin family protein 0.105208 0.34333 1
Onchocerca volvulus Chorion peroxidase homolog 0.00767733 0.0152341 0.0503382
Trypanosoma cruzi histone deacetylase 1, putative 0.0231283 0.067212 0.192774
Loa Loa (eye worm) BEN-1 protein 0.105208 0.34333 0.892661
Echinococcus multilocularis sex peptide receptor 0.0930775 0.302524 0.302524
Schistosoma mansoni tyrosine kinase 0.0166792 0.0455168 0.0577585
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0165279 0.0450077 0.122403
Echinococcus granulosus ephrin type A receptor 4 A 0.0068572 0.0124752 0.0124752
Schistosoma mansoni amine GPCR 0.0930775 0.302524 0.383888
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00732058 0.014034 0.0373089
Schistosoma mansoni sodium-dependent amino acid transporter 0.00444421 0.00435776 0.00552978
Plasmodium vivax vivapain-2 0.00732058 0.014034 0.0312854
Leishmania major beta tubulin 0.105208 0.34333 1
Trypanosoma brucei trypanothione reductase 0.00761339 0.015019 0.0401886
Trichomonas vaginalis histone deacetylase, putative 0.0231283 0.067212 0.187723
Echinococcus multilocularis g protein coupled receptor 0.0930775 0.302524 0.302524
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0101904 0.0236884 0.0236884
Echinococcus multilocularis serotonin receptor 0.102173 0.333123 0.333123
Echinococcus granulosus rhodopsin orphan GPCR 0.0930775 0.302524 0.302524
Loa Loa (eye worm) TK protein kinase 0.00863583 0.0184586 0.0479925
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0930775 0.302524 0.383888
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.00444421 0.00435776 0.00552978
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0930775 0.302524 0.383888
Brugia malayi Papain family cysteine protease containing protein 0.00415925 0.00339916 0.00449102
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0100098 0.0230807 0.0578987
Echinococcus multilocularis cathepsin L 0.00415925 0.00339916 0.00339916
Echinococcus multilocularis neuropeptide Y receptor 0.0930775 0.302524 0.302524
Toxoplasma gondii histone deacetylase HDAC3 0.0231283 0.067212 0.194587
Brugia malayi Cathepsin L-like precursor 0.00732058 0.014034 0.018542
Leishmania major trypanothione reductase 0.00761339 0.015019 0.0401886
Echinococcus multilocularis neuropeptides capa receptor 0.0930775 0.302524 0.302524
Schistosoma mansoni neuropeptide receptor 0.0930775 0.302524 0.383888
Onchocerca volvulus Cathepsin F homolog 0.00732058 0.014034 0.0463711
Loa Loa (eye worm) hypothetical protein 0.00454365 0.00469231 0.0122001
Onchocerca volvulus 0.00767733 0.0152341 0.0503382
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.021476 0.0616536 0.0782353
Schistosoma mansoni amine GPCR 0.0930775 0.302524 0.383888
Brugia malayi Papain family cysteine protease containing protein 0.00732058 0.014034 0.018542
Trichomonas vaginalis conserved hypothetical protein 0.0259271 0.0766272 0.21542
Echinococcus granulosus biogenic amine 5HT receptor 0.132063 0.433672 0.433672
Brugia malayi Tyrosine-protein kinase abl-1 0.0128423 0.0326092 0.0430837
Brugia malayi hypothetical protein 0.0443903 0.138738 0.183303
Echinococcus granulosus tubulin subunit beta 0.105208 0.34333 0.34333
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0101904 0.0236884 0.0236884
Plasmodium falciparum plasmepsin VIII, putative 0.00454365 0.00469231 0.00380416
Echinococcus granulosus epidermal growth factor receptor 0.0305989 0.0923432 0.0923432
Loa Loa (eye worm) TK/CSK protein kinase 0.00552727 0.00800125 0.0208033
Plasmodium vivax vivapain-2 0.00732058 0.014034 0.0312854
Echinococcus granulosus cathepsin L 0.00415925 0.00339916 0.00339916
Trypanosoma brucei beta tubulin 0.105208 0.34333 1
Brugia malayi hypothetical protein 0.0930775 0.302524 0.399699
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0258375 0.0763257 0.0763257
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0165279 0.0450077 0.122403
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Onchocerca volvulus 0.00732058 0.014034 0.0463711
Plasmodium falciparum glutathione reductase 0.00761339 0.015019 0.0341831
Echinococcus multilocularis G protein coupled receptor 139 0.107945 0.352538 0.352538
Onchocerca volvulus 0.00516513 0.00678298 0.0224021
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Echinococcus granulosus tyrosine protein kinase csk 0.00552727 0.00800125 0.00800125
Trypanosoma cruzi trypanothione reductase, putative 0.00761339 0.015019 0.0401886
Treponema pallidum sodium- and chloride- dependent transporter 0.0261804 0.0774793 0.5
Trypanosoma cruzi cruzipain precursor, putative 0.00732058 0.014034 0.0373089
Schistosoma mansoni tyrosine kinase 0.0159928 0.0432077 0.0548285
Loa Loa (eye worm) hypothetical protein 0.00516513 0.00678298 0.0176358
Echinococcus multilocularis dro:myosuppressin receptor 0.0930775 0.302524 0.302524
Brugia malayi hypothetical protein 0.0259271 0.0766272 0.101241
Echinococcus multilocularis tyrosine protein kinase csk 0.00552727 0.00800125 0.00800125
Entamoeba histolytica cysteine proteinase, putative 0.00516513 0.00678298 0.00995444
Plasmodium falciparum plasmepsin VII 0.00454365 0.00469231 0.00380416
Brugia malayi Dopamine receptor protein 2 0.0930775 0.302524 0.399699
Toxoplasma gondii histone deacetylase HDAC4 0.00994152 0.022851 0.065189
Loa Loa (eye worm) hypothetical protein 0.0108844 0.0260227 0.0676592
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00732058 0.014034 0.0312854
Loa Loa (eye worm) proprotein convertase 2 0.0165279 0.0450077 0.11702
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0101904 0.0236884 0.0236884
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00732058 0.014034 0.0312854
Loa Loa (eye worm) norepinephrine transporter 0.0261804 0.0774793 0.201447
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.00444421 0.00435776 0.0113302
Brugia malayi aspartic protease BmAsp-2, identical 0.00454365 0.00469231 0.00619955
Onchocerca volvulus 0.0703174 0.225958 0.746905
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00732058 0.014034 0.0373089
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0443903 0.138738 0.183303
Loa Loa (eye worm) hypothetical protein 0.111394 0.364141 0.946769
Loa Loa (eye worm) aspartyl protease 6 0.00454365 0.00469231 0.0122001
Loa Loa (eye worm) hypothetical protein 0.00315057 0.00000593077 0.00001542
Loa Loa (eye worm) tubulin beta chain 0.105208 0.34333 0.892661
Schistosoma mansoni peroxidasin 0.00767733 0.0152341 0.0193314
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0703174 0.225958 0.298539
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00454365 0.00469231 0.00595431
Plasmodium falciparum plasmepsin III 0.00454365 0.00469231 0.00380416
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0439776 0.13735 0.394053
Trypanosoma brucei beta tubulin 0.105208 0.34333 1
Schistosoma mansoni tubulin subunit beta 0.105208 0.34333 0.435669
Loa Loa (eye worm) hypothetical protein 0.00767733 0.0152341 0.0396089
Schistosoma mansoni tyrosine kinase 0.0101904 0.0236884 0.0300594
Echinococcus granulosus tm gpcr rhodopsin 0.30041 1 1
Echinococcus granulosus histone deacetylase 6 0.0208259 0.0594664 0.0594664
Trypanosoma cruzi cysteine proteinase, putative 0.00415925 0.00339916 0.00621811
Echinococcus granulosus beta tubulin 0.105208 0.34333 0.34333
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0930775 0.302524 0.383888
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0261804 0.0774793 0.102367
Loa Loa (eye worm) histone deacetylase 11 0.00994152 0.022851 0.0594127
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0142889 0.0374758 0.100246
Schistosoma mansoni tyrosine kinase 0.0159928 0.0432077 0.0548285
Echinococcus multilocularis cathepsin b 0.021476 0.0616536 0.0616536
Loa Loa (eye worm) hypothetical protein 0.0443903 0.138738 0.36072
Trypanosoma cruzi cysteine peptidase, putative 0.00732058 0.014034 0.0373089
Echinococcus granulosus histone deacetylase 3 0.0231283 0.067212 0.067212
Loa Loa (eye worm) histone deacetylase 3 0.0231283 0.067212 0.174752
Loa Loa (eye worm) hypothetical protein 0.0259271 0.0766272 0.199231
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.30041 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0930775 0.302524 0.383888
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0930775 0.302524 0.399699
Echinococcus granulosus insulin growth factor 1 receptor beta 0.010361 0.0242621 0.0242621
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Brugia malayi follicle stimulating hormone receptor 0.0930775 0.302524 0.399699
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00732058 0.014034 0.0312854
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Echinococcus multilocularis insulin receptor 0.0101288 0.0234809 0.0234809
Brugia malayi Cathepsin L-like precursor 0.00732058 0.014034 0.018542
Echinococcus granulosus rhodopsin orphan GPCR 0.0930775 0.302524 0.302524
Loa Loa (eye worm) cysteine protease 0.00732058 0.014034 0.0364886
Schistosoma mansoni opsin-like receptor 0.0930775 0.302524 0.383888
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0930775 0.302524 0.786565
Onchocerca volvulus 0.00732058 0.014034 0.0463711
Echinococcus multilocularis rhodopsin orphan GPCR 0.0930775 0.302524 0.302524
Echinococcus multilocularis neuropeptide receptor A26 0.0930775 0.302524 0.302524
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0930775 0.302524 0.383888
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.00444421 0.00435776 1
Brugia malayi G-protein coupled receptor 0.0930775 0.302524 0.399699
Brugia malayi Animal haem peroxidase family protein 0.00767733 0.0152341 0.0201276
Loa Loa (eye worm) hypothetical protein 0.00516513 0.00678298 0.0176358
Onchocerca volvulus 0.0703174 0.225958 0.746905
Brugia malayi aspartic protease BmAsp-1, identical 0.00454365 0.00469231 0.00619955
Leishmania major histone deacetylase, putative 0.0231283 0.067212 0.192774
Trypanosoma brucei histone deacetylase, putative 0.0208259 0.0594664 0.17013
Brugia malayi Cathepsin L-like cysteine proteinase 0.00516513 0.00678298 0.00896178
Loa Loa (eye worm) tubulin beta-2A chain 0.105208 0.34333 0.892661
Loa Loa (eye worm) hypothetical protein 0.00767733 0.0152341 0.0396089
Loa Loa (eye worm) hypothetical protein 0.00732058 0.014034 0.0364886
Schistosoma mansoni hypothetical protein 0.0930775 0.302524 0.383888
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Brugia malayi Blistered cuticle protein 3 0.00767733 0.0152341 0.0201276
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0930775 0.302524 0.399699
Loa Loa (eye worm) hypothetical protein 0.00767733 0.0152341 0.0396089
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0930775 0.302524 0.383888
Leishmania major beta tubulin 0.105208 0.34333 1
Echinococcus granulosus serotonin transporter 0.0261804 0.0774793 0.0774793
Onchocerca volvulus 0.0443903 0.138738 0.458591
Trypanosoma brucei cysteine peptidase C (CPC) 0.0100098 0.0230807 0.0637568
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Trypanosoma brucei histone deacetylase 1 0.0231283 0.067212 0.192774
Entamoeba histolytica cysteine proteinase, putative 0.00732058 0.014034 0.0312854
Trichomonas vaginalis conserved hypothetical protein 0.0142889 0.0374758 0.100246
Schistosoma mansoni alpha-1 adrenergic receptor 0.0930775 0.302524 0.383888
Loa Loa (eye worm) hypothetical protein 0.00767733 0.0152341 0.0396089
Echinococcus granulosus dro:myosuppressin receptor 0.0930775 0.302524 0.302524
Schistosoma mansoni tubulin subunit beta 0.105208 0.34333 0.435669
Schistosoma mansoni histone deacetylase 4 5 0.0208259 0.0594664 0.0754599
Onchocerca volvulus 0.0930775 0.302524 1
Loa Loa (eye worm) hypothetical protein 0.00444421 0.00435776 0.0113302
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0930775 0.302524 0.302524
Echinococcus multilocularis G-protein coupled receptor, putative 0.0930775 0.302524 0.302524
Loa Loa (eye worm) TK/EGFR protein kinase 0.0305989 0.0923432 0.240093
Echinococcus granulosus Tubulin beta 2C chain 0.105208 0.34333 0.34333
Toxoplasma gondii histone deacetylase HDAC1 0.0208259 0.0594664 0.171993
Loa Loa (eye worm) histone deacetylase 0.0208259 0.0594664 0.154613
Echinococcus granulosus rhodopsin orphan GPCR 0.0930775 0.302524 0.302524
Leishmania major beta tubulin 0.105208 0.34333 1
Echinococcus multilocularis serotonin transporter 0.0261804 0.0774793 0.0774793
Brugia malayi protein-tyrosine kinase 0.00863583 0.0184586 0.0243878
Echinococcus granulosus dnaJ subfamily B 0.237407 0.788053 0.788053
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0930775 0.302524 0.302524
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0201104 0.0570597 0.0570597
Loa Loa (eye worm) neuropeptide F receptor 0.0930775 0.302524 0.786565
Brugia malayi Histone deacetylase family protein 0.0208259 0.0594664 0.0785679
Echinococcus granulosus serotonin receptor 0.0930775 0.302524 0.302524
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00732058 0.014034 0.0312854
Echinococcus multilocularis histone deacetylase 6 0.0208259 0.0594664 0.0594664
Schistosoma mansoni sodium/chloride dependent transporter 0.0261804 0.0774793 0.0983174
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0142889 0.0374758 0.100246
Echinococcus granulosus allatostatin A receptor 0.0930775 0.302524 0.302524
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0930775 0.302524 0.302524
Loa Loa (eye worm) insulin-degrading enzyme 0.00352699 0.00127221 0.00330776
Toxoplasma gondii beta-tubulin, putative 0.105208 0.34333 1
Loa Loa (eye worm) BEN-1 protein 0.105208 0.34333 0.892661
Echinococcus granulosus beta tubulin 0.105208 0.34333 0.34333
Onchocerca volvulus 0.0930775 0.302524 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00732058 0.014034 0.0373089
Schistosoma mansoni growth hormone secretagogue receptor 0.0930775 0.302524 0.383888
Echinococcus granulosus nardilysin 0.00352699 0.00127221 0.00127221
Schistosoma mansoni sodium/chloride dependent transporter 0.00448889 0.00450809 0.00572053
Brugia malayi hypothetical protein 0.00454365 0.00469231 0.00619955
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00454365 0.00469231 0.00595431
Echinococcus multilocularis histone deacetylase 3 0.0231283 0.067212 0.067212
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0930775 0.302524 0.383888
Echinococcus multilocularis tyrosine protein kinase Abl 0.0128423 0.0326092 0.0326092
Schistosoma mansoni histone deacetylase 1 2 3 0.00994152 0.022851 0.0289967
Echinococcus granulosus sodium and chloride dependent glycine 0.00444421 0.00435776 0.00435776
Loa Loa (eye worm) hypothetical protein 0.00767733 0.0152341 0.0396089
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0930775 0.302524 0.302524
Leishmania major histone deacetylase, putative 0.0231283 0.067212 0.192774
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00732058 0.014034 0.0312854
Echinococcus granulosus tyrosine protein kinase Btk29A 0.00383521 0.00230907 0.00230907
Loa Loa (eye worm) hypothetical protein 0.00767733 0.0152341 0.0396089
Schistosoma mansoni cathepsin F (C01 family) 0.00732058 0.014034 0.0178085
Echinococcus granulosus cathepsin L cysteine proteinase 0.00732058 0.014034 0.014034
Leishmania major beta tubulin 0.105208 0.34333 1
Trypanosoma cruzi cysteine peptidase, putative 0.00732058 0.014034 0.0373089
Trichomonas vaginalis histone deacetylase, putative 0.0231283 0.067212 0.187723
Schistosoma mansoni biogenic amine receptor 0.0930775 0.302524 0.383888
Plasmodium falciparum cysteine proteinase falcipain 3 0.00732058 0.014034 0.0312854
Echinococcus multilocularis neuropeptide FF receptor 2 0.111394 0.364141 0.364141
Trichomonas vaginalis tubulin gamma chain, putative 0.105208 0.34333 1
Toxoplasma gondii cathepsin CPL 0.00732058 0.014034 0.0394707
Loa Loa (eye worm) TK protein kinase 0.00704164 0.0130957 0.0340488
Schistosoma mansoni amine GPCR 0.0930775 0.302524 0.383888
Brugia malayi GnHR receptor homolog 0.22814 0.75688 1
Echinococcus multilocularis tubulin beta 1 chain 0.105208 0.34333 0.34333
Echinococcus granulosus tyrosine protein kinase csk 0.00552727 0.00800125 0.00800125
Loa Loa (eye worm) histone deacetylase 7A 0.0208259 0.0594664 0.154613
Echinococcus granulosus neuropeptides capa receptor 0.0930775 0.302524 0.302524
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0201104 0.0570597 0.148355
Echinococcus granulosus neuropeptide receptor 0.107945 0.352538 0.352538
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00732058 0.014034 0.0373089
Schistosoma mansoni histone deacetylase hda2 0.0216786 0.062335 0.0791
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.00516513 0.00678298 0.0161106
Schistosoma mansoni nardilysin (M16 family) 0.00352699 0.00127221 0.00161437
Echinococcus multilocularis biogenic amine (5HT) receptor 0.132063 0.433672 0.433672
Onchocerca volvulus 0.00454365 0.00469231 0.0154912
Echinococcus granulosus Tubulin beta 2C chain 0.105208 0.34333 0.34333
Onchocerca volvulus 0.00732058 0.014034 0.0463711
Echinococcus granulosus hypothetical protein 0.0930775 0.302524 0.302524
Echinococcus granulosus Tubulin beta 2C chain 0.105208 0.34333 0.34333
Echinococcus granulosus neuropeptides capa receptor 0.0930775 0.302524 0.302524
Schistosoma mansoni neuropeptide F-like receptor 0.0930775 0.302524 0.383888
Echinococcus granulosus tyrosine protein kinase Src42A 0.00794944 0.0161495 0.0161495
Toxoplasma gondii hypothetical protein 0.00444421 0.00435776 0.0112459
Brugia malayi ORL1-like opioid receptor 0.0930775 0.302524 0.399699
Entamoeba histolytica cysteine proteinase, putative 0.00732058 0.014034 0.0312854
Echinococcus granulosus tyrosine protein kinase ABL1 0.0258375 0.0763257 0.0763257
Plasmodium falciparum plasmepsin I 0.0192184 0.0540589 0.14903
Plasmodium falciparum plasmepsin II 0.0192184 0.0540589 0.14903
Leishmania major beta tubulin 0.105208 0.34333 1
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Echinococcus multilocularis rhodopsin orphan GPCR 0.0930775 0.302524 0.302524
Schistosoma mansoni sodium/chloride dependent transporter 0.00444421 0.00435776 0.00552978
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0192184 0.0540589 0.15622
Leishmania major beta tubulin 0.105208 0.34333 1
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.00444421 0.00435776 0.00435776
Echinococcus granulosus Tubulin beta 2C chain 0.105208 0.34333 0.34333
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.00761339 0.015019 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0142889 0.0374758 0.100246
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.0333333 0.101542 0.101542
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0930775 0.302524 0.302524
Loa Loa (eye worm) cathepsin B 0.0100098 0.0230807 0.0600101
Trypanosoma cruzi histone deacetylase 1, putative 0.0231283 0.067212 0.192774
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0165279 0.0450077 0.122403
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00516513 0.00678298 0.00995444
Echinococcus granulosus c src tyrosine kinase 0.00867608 0.018594 0.018594
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.00793631 0.0161054 0.0161054
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0930775 0.302524 0.399699
Loa Loa (eye worm) hypothetical protein 0.0443903 0.138738 0.36072
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Onchocerca volvulus 0.0259271 0.0766272 0.253278
Schistosoma mansoni tyrosine kinase 0.0242433 0.0709628 0.0900482
Trichomonas vaginalis histone deacetylase, putative 0.0231283 0.067212 0.187723
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Echinococcus multilocularis tubulin, beta 4A class IVa 0.105208 0.34333 0.34333
Loa Loa (eye worm) TK/EPH protein kinase 0.00854898 0.0181664 0.0472328
Echinococcus multilocularis rhodopsin orphan GPCR 0.0930775 0.302524 0.302524
Schistosoma mansoni opsin-like receptor 0.0930775 0.302524 0.383888
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00732058 0.014034 0.0373089
Toxoplasma gondii rhoptry metalloprotease toxolysin TLN1 0.00352699 0.00127221 0.00224556
Trypanosoma cruzi cysteine proteinase, putative 0.00415925 0.00339916 0.00621811
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00732058 0.014034 0.0373089
Loa Loa (eye worm) tubulin beta-4 chain 0.105208 0.34333 0.892661
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00732058 0.014034 0.0312854
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00454365 0.00469231 0.00595431
Onchocerca volvulus 0.0930775 0.302524 1
Trypanosoma brucei beta tubulin 0.105208 0.34333 1
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0443903 0.138738 0.183303
Brugia malayi Matrixin family protein 0.00527779 0.00716198 0.00946251
Brugia malayi beta-tubulin, identical 0.105208 0.34333 0.453613
Onchocerca volvulus 0.0930775 0.302524 1
Onchocerca volvulus 0.00444421 0.00435776 0.0143854
Leishmania major beta tubulin 0.105208 0.34333 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0930775 0.302524 0.383888
Toxoplasma gondii histone deacetylase HDAC5 0.00994152 0.022851 0.065189
Giardia lamblia High cysteine membrane protein Group 2 0.0274497 0.0817494 0.183197
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00516513 0.00678298 0.00995444
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0142889 0.0374758 0.100246
Leishmania major beta tubulin 0.105208 0.34333 1
Echinococcus granulosus neuropeptide s receptor 0.0930775 0.302524 0.302524
Trichomonas vaginalis conserved hypothetical protein 0.0142889 0.0374758 0.100246
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0729523 0.234822 0.297978
Loa Loa (eye worm) hypothetical protein 0.00767733 0.0152341 0.0396089
Echinococcus granulosus tubulin beta 1 chain 0.105208 0.34333 0.34333
Plasmodium falciparum plasmepsin X 0.00454365 0.00469231 0.00380416
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0930775 0.302524 0.302524
Toxoplasma gondii hypothetical protein 0.00444421 0.00435776 0.0112459
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0101904 0.0236884 0.0236884
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0930775 0.302524 0.383888
Echinococcus granulosus 3'partial|nardilysin 0.00352699 0.00127221 0.00127221
Echinococcus granulosus insulin receptor 0.0101288 0.0234809 0.0234809
Leishmania major histone deacetylase, putative 0.0208259 0.0594664 0.17013
Schistosoma mansoni adenoreceptor 0.0930775 0.302524 0.383888
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Echinococcus multilocularis beta tubulin 0.105208 0.34333 0.34333
Echinococcus multilocularis tyrosine protein kinase csk 0.00552727 0.00800125 0.00800125
Onchocerca volvulus 0.0930775 0.302524 1
Loa Loa (eye worm) fibroinase 0.00732058 0.014034 0.0364886
Onchocerca volvulus 0.0703174 0.225958 0.746905
Loa Loa (eye worm) hypothetical protein 0.00444421 0.00435776 0.0113302
Leishmania major cathepsin L-like protease 0.00732058 0.014034 0.0373089
Loa Loa (eye worm) hypothetical protein 0.00767733 0.0152341 0.0396089
Brugia malayi cathepsin L-like precursor 0.00516513 0.00678298 0.00896178
Loa Loa (eye worm) tubulin beta-1 chain 0.105208 0.34333 0.892661
Echinococcus granulosus G protein coupled receptor 139 0.0930775 0.302524 0.302524
Brugia malayi Eukaryotic aspartyl protease family protein 0.00454365 0.00469231 0.00619955
Onchocerca volvulus Neuropeptide F receptor homolog 0.0930775 0.302524 1
Brugia malayi histone deacetylase 3 (HD3) 0.0231283 0.067212 0.0888015
Schistosoma mansoni septate junction protein 0.00373818 0.00198267 0.00251591
Leishmania major beta tubulin 0.105208 0.34333 1
Loa Loa (eye worm) hypothetical protein 0.0259271 0.0766272 0.199231
Brugia malayi Histone deacetylase family protein 0.0208259 0.0594664 0.0785679
Onchocerca volvulus 0.0443903 0.138738 0.458591
Schistosoma mansoni neuropeptide F-like receptor 0.0930775 0.302524 0.383888
Loa Loa (eye worm) hypothetical protein 0.00767733 0.0152341 0.0396089
Brugia malayi hypothetical protein 0.00767733 0.0152341 0.0201276
Echinococcus granulosus neuropeptide FF receptor 2 0.111394 0.364141 0.364141
Schistosoma mansoni biogenic amine (5HT) receptor 0.102173 0.333123 0.422716
Brugia malayi cathepsin B-like cysteine proteinase 0.021476 0.0616536 0.0814576
Onchocerca volvulus 0.00767733 0.0152341 0.0503382
Echinococcus granulosus rhodopsin orphan GPCR 0.0930775 0.302524 0.302524
Echinococcus multilocularis rhodopsin orphan GPCR 0.0930775 0.302524 0.302524
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0930775 0.302524 0.383888
Loa Loa (eye worm) hypothetical protein 0.0930775 0.302524 0.786565
Schistosoma mansoni tubulin subunit beta 0.105208 0.34333 0.435669
Brugia malayi Peroxidasin 0.00767733 0.0152341 0.0201276
Loa Loa (eye worm) hypothetical protein 0.00767733 0.0152341 0.0396089
Onchocerca volvulus 0.0061708 0.0101661 0.0335854
Onchocerca volvulus 0.0930775 0.302524 1
Plasmodium vivax histone deacetylase 1, putative 0.0231283 0.067212 0.187723
Echinococcus granulosus tm gpcr rhodopsin 0.180847 0.597786 0.597786

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) Toxicity against Trypanosoma cruzi infected CD1 mouse assessed as effect on liver histology at 300 mg/kg, ip ChEMBL. 18255195
Activity (ADMET) Toxicity against Trypanosoma cruzi infected CD1 mouse assessed as effect on kidney histology at 300 mg/kg, ip ChEMBL. 18255195
Activity (functional) Antitrypanosomal activity against Trypanosoma cruzi Argentinian isolate infected Swiss mouse assessed as prevention of skeletal muscle inflammatory infiltrates at 60 mg/kg/day, po ChEMBL. 18255195
Activity (functional) Antitrypanosomal activity against Trypanosoma cruzi Argentinian isolate infected Swiss mouse assessed as prevention of heart inflammatory infiltrates at 60 mg/kg/day, po ChEMBL. 18255195
Activity (ADMET) Toxicity against Trypanosoma cruzi infected CD1 mouse assessed as effect on heart histology at 450 mg/kg, po ChEMBL. 18255195
Activity (ADMET) Toxicity against Trypanosoma cruzi infected CD1 mouse assessed as effect on kidney histology at 450 mg/kg, po ChEMBL. 18255195
Activity (functional) Antitrypanosomal activity against Trypanosoma cruzi Argentinian isolate infected Swiss mouse assessed as inhibition of heart amastigote nests at 60 mg/kg/day, po ChEMBL. 18255195
Activity (functional) Antimicrobial activity against Trypanosoma brucei infected in NMRI mouse assessed as decrease in parasitemia level at 100 mg/kg, ip QD for 3 days measured after 30 days by neubuaer hemocytometry ChEMBL. 20439607
Activity (ADMET) Toxicity against Trypanosoma cruzi infected CD1 mouse assessed as effect on liver histology at 450 mg/kg, po ChEMBL. 18255195
Activity (functional) Antitrypanosomal activity against Trypanosoma cruzi Argentinian isolate infected Swiss mouse assessed as prevention of liver congestion at 60 mg/kg/day, po ChEMBL. 18255195
Activity (ADMET) Toxicity against Trypanosoma cruzi infected CD1 mouse assessed as effect on heart histology at 300 mg/kg, ip ChEMBL. 18255195
Activity (ADMET) Toxicity in NMRI mouse up to 200 mg/kg, ip QD daily for 3 days ChEMBL. 20439607
Activity (functional) Antitrypanosomal activity against Trypanosoma cruzi Argentinian isolate infected Swiss mouse assessed as inhibition of skeletal muscle amastigote nests at 60 mg/kg/day, po ChEMBL. 18255195
Activity (functional) = 0 % Unspecific cytotoxicity against murine J774 macrophages at 1 ug/ml ChEMBL. 16455249
Activity (functional) = 0 % Unspecific cytotoxicity against murine J774 macrophages at 1 ug/ml ChEMBL. 16455249
Activity (ADMET) = 0 % Toxicity in CD1 mouse assessed as decrease in weight respect to day zero at 300 mg/kg, po after 3 days ChEMBL. 19446929
Activity (ADMET) = 0 % Cytotoxicity against mouse J774 cells assessed as reduction in cell viability at 1 ug/ml after 24 hrs by resazurin-based colorimetric assay ChEMBL. 21605926
Activity (ADMET) = 0 % Cytotoxicity against mouse J774 cells at 1 ug/mL after 24 hrs by MTT assay ChEMBL. 24513185
Activity (functional) = 0.6 % Unspecific cytotoxicity against murine J774 macrophages at 10 ug/ml ChEMBL. 16455249
Activity (functional) = 0.6 % Unspecific cytotoxicity against murine J774 macrophages at 10 ug/ml ChEMBL. 16455249
Activity (ADMET) = 0.6 % Cytotoxicity against mouse J774 cells assessed as reduction in cell viability at 10 ug/ml after 24 hrs by resazurin-based colorimetric assay ChEMBL. 21605926
Activity (ADMET) = 3 % Toxicity in CD1 mouse assessed as decrease in weight respect to day zero at 300 mg/kg, ip after 3 days ChEMBL. 19446929
Activity (ADMET) = 6 % Toxicity in CD1 mouse assessed as decrease in weight respect to day zero at 450 mg/kg, po after 3 days ChEMBL. 19446929
Activity (functional) = 25.9 % Unspecific cytotoxicity against murine J774 macrophages at 100 ug/ml ChEMBL. 16455249
Activity (functional) = 25.9 % Unspecific cytotoxicity against murine J774 macrophages at 100 ug/ml ChEMBL. 16455249
Activity (ADMET) = 25.9 % Cytotoxicity against mouse J774 cells assessed as reduction in cell viability at 100 ug/ml after 24 hrs by resazurin-based colorimetric assay ChEMBL. 21605926
Activity (ADMET) = 39.3 % Toxicity in CD1 mouse assessed as hematocrite level at 300 mg/kg, ip after 3 days ChEMBL. 19446929
Activity (ADMET) = 40 % Cytotoxicity against human Caco-2 cells at 25 uM by MTT assay ChEMBL. 19900812
Activity (ADMET) = 42 % Cytotoxicity against mouse L929 cells assessed as metabolic activity at 100 uM after 48 hrs by Alamar Blue assay relative to untreated control ChEMBL. 25576738
Activity (ADMET) = 42.4 % Toxicity in CD1 mouse assessed as hematocrite level at 450 mg/kg, po after 3 days ChEMBL. 19446929
Activity (functional) = 50.89 % Antitrypanosomal activity against Trypanosoma cruzi SN3 trypomastigotes infected in african green monkey Vero cells assessed as parasite viability at 3.4 uM after 24 hrs by MTT assay ChEMBL. 18762357
Activity (functional) = 52.5 % Antitrypanosomal activity against trypomastigote stage of Trypanosoma cruzi Dm28c at 10 umol/L after 24 hrs by MTT assay ChEMBL. 22832320
Activity (functional) = 52.5 % Antitrypanosomal activity against Trypanosoma cruzi Dm28c epimastigotes assessed as non-viable epimastigotes at 10 umol/L after 4 hrs by MTT assay relative to untreated control ChEMBL. No reference
Activity (functional) = 66.3 % Antitrypanosomal activity against Trypanosoma cruzi Tulahuen assessed as trypomastigote viability at 9.5 uM by MTT assay relative to control ChEMBL. 18029184
Activity (functional) = 66.3 % Antitrypanosomal activity against Trypanosoma cruzi Tulahuen assessed as trypomastigote viability at 9.5 uM by MTT assay relative to control ChEMBL. 18029184
Activity (functional) = 75.5 % Antitrypanosomal activity against Trypanosoma cruzi epimastigotes at 1 ug/ml ChEMBL. 16455249
Activity (functional) = 75.5 % Antitrypanosomal activity against Trypanosoma cruzi epimastigotes at 1 ug/ml ChEMBL. 16455249
Activity (functional) = 75.5 % Antitrypanosomal activity against epimastigote forms of Trypanosoma cruzi CL-B5 transfected with Escherichia coli beta-galactosidase gene LacZ at 1 ug/ml after 72 hrs by chlorophenol red-Beta-D-galactopyranoside-based assay ChEMBL. 21605926
Activity (functional) = 75.5 % Trypanocidal activity against epimastigote stage of Trypanosoma cruzi CL Brener at 1 ug/mL after 72 hrs by beta-galactosidase reporter gene assay relative to control ChEMBL. 24513185
Activity (functional) = 80 % Effect on oxygen redox cycling in Trypanosoma cruzi Y epimastigotes assessed as rate of oxygen consumption at 180 uM in presence of cyanide relative to control ChEMBL. 17981471
Activity (functional) = 80 % Effect on oxygen redox cycling in Trypanosoma cruzi Y epimastigotes assessed as rate of oxygen consumption at 180 uM in presence of cyanide relative to control ChEMBL. 17981471
Activity (functional) = 80 % Antitrypanosomal activity against Trypanosoma cruzi Y epimastigotes assessed as cell death at 10 uM after 2 days by MTT assay relative to control ChEMBL. 21506600
Activity (functional) = 87 % Antitrypanosomal activity against Trypanosoma cruzi Colombiana assessed as parasitic cytotoxicity at 25 uM after 5 days by MTT assay ChEMBL. 19616875
Activity (functional) = 87 % Antitrypanosomal activity against Trypanosoma cruzi Colombiana epimastigotes assessed as cell death at 10 uM after 2 days by MTT assay relative to control ChEMBL. 21506600
Activity (functional) = 88.1 % Antitrypanosomal activity against Trypanosoma cruzi amastigotes at 1 ug/ml ChEMBL. 16455249
Activity (functional) = 88.1 % Antitrypanosomal activity against Trypanosoma cruzi amastigotes at 1 ug/ml ChEMBL. 16455249
Activity (functional) = 88.14 % Antitrypanosomal activity against amastigote forms of Trypanosoma cruzi CL-B5 expressing Escherichia coli LacZ gene infected in NCTC929 fibroblasts at 1 ug/ml after 7 days by chlorophenol red-Beta-D-galactopyranoside-based assay ChEMBL. 21605926
Activity (functional) = 90 % Antitrypanosomal activity against Trypanosoma cruzi epimastigotes at 10 ug/ml ChEMBL. 16455249
Activity (functional) = 90 % Antitrypanosomal activity against Trypanosoma cruzi epimastigotes at 10 ug/ml ChEMBL. 16455249
Activity (functional) = 90 % Antitrypanosomal activity against Trypanosoma cruzi CL Brener epimastigotes assessed as parasitic cytotoxicity at 25 uM after 5 days by MTT assay ChEMBL. 19616875
Activity (functional) = 90 % Antitrypanosomal activity against Trypanosoma cruzi CL Brener clone epimastigotes assessed as cell death at 10 uM after 2 days by MTT assay relative to control ChEMBL. 21506600
Activity (functional) = 90 % Antitrypanosomal activity against epimastigote forms of Trypanosoma cruzi CL-B5 transfected with Escherichia coli beta-galactosidase gene LacZ at 10 ug/ml after 72 hrs by chlorophenol red-Beta-D-galactopyranoside-based assay ChEMBL. 21605926
Activity (functional) = 94.2 % Antiparasitic activity against Trypanosoma cruzi Y trypomastigotes infected in rhesus monkey LLC-MK2 cells followed by re-infection of amastigotes in human U2OS cells assessed as reduction in parasite infection level after 96 hrs by draq5 staining based assay relative to control ChEMBL. 26774924
Activity (functional) = 94.4 % Antitrypanosomal activity against Trypanosoma cruzi amastigotes at 10 ug/ml ChEMBL. 16455249
Activity (functional) = 94.4 % Antitrypanosomal activity against Trypanosoma cruzi amastigotes at 10 ug/ml ChEMBL. 16455249
Activity (functional) = 94.44 % Antitrypanosomal activity against amastigote forms of Trypanosoma cruzi CL-B5 expressing Escherichia coli LacZ gene infected in NCTC929 fibroblasts at 10 ug/ml after 7 days by chlorophenol red-Beta-D-galactopyranoside-based assay ChEMBL. 21605926
Activity (functional) = 98.7 % Antitrypanosomal activity against Trypanosoma cruzi epimastigotes at 100 ug/ml ChEMBL. 16455249
Activity (functional) = 98.7 % Antitrypanosomal activity against Trypanosoma cruzi epimastigotes at 100 ug/ml ChEMBL. 16455249
Activity (functional) = 98.7 % Antitrypanosomal activity against epimastigote forms of Trypanosoma cruzi CL-B5 transfected with Escherichia coli LacZ gene at 100 ug/ml after 72 hrs by chlorophenol red-Beta-D-galactopyranoside-based assay ChEMBL. 21605926
Activity (functional) = 100 % Antitrypanosomal activity against Trypanosoma cruzi amastigotes at 100 ug/ml ChEMBL. 16455249
Activity (functional) = 100 % Antitrypanosomal activity against Trypanosoma cruzi infected NMRI mice at 50 mg/kg/day ChEMBL. 16455249
Activity (functional) = 100 % Antitrypanosomal activity against Trypanosoma cruzi amastigotes at 100 ug/ml ChEMBL. 16455249
Activity (functional) = 100 % Antitrypanosomal activity against Trypanosoma cruzi infected NMRI mice at 50 mg/kg/day ChEMBL. 16455249
Activity (functional) = 100 % Antitrypanosomal activity against amastigote forms of Trypanosoma cruzi CL-B5 expressing Escherichia coli LacZ gene infected in NCTC929 fibroblasts at 100 ug/ml after 7 days by chlorophenol red-Beta-D-galactopyranoside-based assay ChEMBL. 21605926
Activity (functional) = 100 % Antitrypanosomal activity against Trypanosoma cruzi Dm28c epimastigotes assessed as non-viable epimastigotes at 100 umol/L after 4 hrs by MTT assay relative to untreated control ChEMBL. No reference
Activity (functional) = 113 % Effect on oxygen redox cycling in Trypanosoma cruzi Tulahuen assessed as oxygen consumption per mg of protein relative to control ChEMBL. 18029184
Activity (functional) = 113 % Effect on oxygen redox cycling in Trypanosoma cruzi Tulahuen assessed as oxygen consumption per mg of protein relative to control ChEMBL. 18029184
Activity (functional) = 117 % Effect on oxygen uptake in Trypanosoma cruzi Y epimastigotes assessed as rate of oxygen consumption at 180 uM relative to control ChEMBL. 17981471
Activity (functional) = 117 % Effect on oxygen uptake in Trypanosoma cruzi Y epimastigotes assessed as rate of oxygen consumption at 180 uM relative to control ChEMBL. 17981471
Activity (functional) = 120.4 % Effect on oxygen uptake per mg of protein in Trypanosoma cruzi Tulahuen epimastigotes relative to control ChEMBL. 18029184
Activity (functional) = 120.4 % Effect on oxygen uptake per mg of protein in Trypanosoma cruzi Tulahuen epimastigotes relative to control ChEMBL. 18029184
Activity (ADMET) = 5100 /uL Toxicity in CD1 mouse assessed as leukocyte level at 300 mg/kg, ip after 3 days ChEMBL. 19446929
Activity (ADMET) = 6700 /uL Toxicity in CD1 mouse assessed as leukocyte level at 450 mg/kg, po after 3 days ChEMBL. 19446929
Activity (ADMET) = 13.2 g/L Toxicity in CD1 mouse assessed as haemoglobin level at 300 mg/kg, ip after 3 days ChEMBL. 19446929
Activity (ADMET) = 13.5 g/L Toxicity in CD1 mouse assessed as haemoglobin level at 450 mg/kg, po after 3 days ChEMBL. 19446929
Activity (ADMET) = 32.5 IU/L Toxicity in CD1 mouse assessed as glutamic-pyruvate transaminase level at 300 mg/kg, ip after 3 days ChEMBL. 19446929
Activity (ADMET) = 49 IU/L Toxicity in CD1 mouse assessed as glutamic-pyruvate transaminase level at 450 mg/kg, po after 3 days ChEMBL. 19446929
Activity (ADMET) = 162 IU/L Toxicity in CD1 mouse assessed as glutamic-oxalacetate transaminase level at 450 mg/kg, po after 3 days ChEMBL. 19446929
Activity (ADMET) = 177 IU/L Toxicity in CD1 mouse assessed as glutamic-oxalacetate transaminase level at 300 mg/kg, ip after 3 days ChEMBL. 19446929
Activity (functional) = 0.6 ug ml-1 Increase in squalene biosynthesis in Trypanosoma cruzi tulahuen 2 epimastigotes at ID50 concentration per 8 x 10'6 cells/ml after 120 mins by HPLC analysis (Rvb=0.6 to 2.1 ug/ml) ChEMBL. 19811923
CC50 (functional) = 2.7 uM Antitrypanosomal activity against Trypanosoma cruzi Y metacyclic trypomastigotes isolated from infected LLC-MK2 cells assessed as parasite viability after 24 hrs by neubauer chamber analysis ChEMBL. 24561675
CC50 (functional) = 2.7 uM Antiparasitic activity against trypomastigotes of Trypanosoma cruzi Y assessed as reduction of parasite count after 24 hrs ChEMBL. 26231082
CC50 (functional) > 50 uM Tested for cytotoxicity towards human MRC-5 cells ChEMBL. 12443785
CC50 (functional) > 50 uM Tested for cytotoxicity towards human MRC-5 cells ChEMBL. 12443785
CC50 (ADMET) = 97.2 uM Cytotoxicity against human U2OS cells assessed as reduction in cell viability ChEMBL. 26774924
delta logD (ADMET) = 0 Delta logD (logD6.5 - logD7.4) ChEMBL. 10891117
Drug uptake (ADMET) = 3 uM Drug level in serum of patient with human african trypanosomiasis at 15 mg/kg, po administered every 8 hrs for 10 days ChEMBL. 20439607
EC50 (functional) = 1708 nM Trypanocidal activity against Trypanosoma brucei rhodesiense Z310 after 72 hrs by Alamar blue assay ChEMBL. 23281892
EC50 (functional) = 0.26 uM Antimicrobial activity against Trypanosoma brucei gambiense ChEMBL. 20439607
EC50 (functional) = 0.7 uM Antitrypanosomal activity against Trypanosoma cruzi Sylvio-X10/7 infected in BESM cells measured after 88 hrs postinfection by HTS assay ChEMBL. 20547819
EC50 (functional) = 1.2 uM Antitrypanosomal activity against Trypanosoma cruzi CA-I/72 infected in BESM cells measured after 88 hrs postinfection by HTS assay ChEMBL. 20547819
EC50 (functional) = 1.26 uM Antiparasitic activity against Trypanosoma cruzi Y trypomastigotes infected in rhesus monkey LLC-MK2 cells followed by re-infection of amastigotes in human U2OS cells assessed as reduction in parasite infection level after 96 hrs by draq5 staining based assay ChEMBL. 26774924
EC50 (functional) = 2.1 uM Antitrypanosomal activity against Trypanosoma cruzi PSD-I infected in BESM cells measured after 88 hrs postinfection by HTS assay ChEMBL. 20547819
EC50 (functional) = 2.4 uM Antimicrobial activity against Trypanosoma brucei ChEMBL. 20439607
EC50 (functional) = 7.3 uM Trypanocidal activity against bloodstream form of N-(4-(allyloxy)-3-(trifluoromethyl)phenyl)-5-nitrofuran-2-carboxamide-resistant Trypanosoma brucei after 72 hrs by Alamar blue assay ChEMBL. 23281892
EC50 (functional) = 20.1 uM Antimicrobial activity against Trypanosoma brucei NfxR1 ChEMBL. 20439607
EC50 (functional) = 20.3 uM Antimicrobial activity against Trypanosoma brucei NfxR2 ChEMBL. 20439607
EC50 (ADMET) = 91.2 uM Cytotoxicity against human HeLa cells after 65 hrs by Alamar blue assay ChEMBL. 23281892
ED50 (functional) = 36.7 mg kg-1 Antimicrobial activity against Trypanosoma brucei infected in NMRI mouse at 128 mg/kg, ip QD for 4 days ChEMBL. 20439607
ED50 (functional) = 0.4 uM Evaluated in vitro for antitrypanosomal activity against Trypanosoma cruzi ChEMBL. 12443785
ED50 (functional) = 0.4 uM Evaluated in vitro for antitrypanosomal activity against Trypanosoma cruzi ChEMBL. 12443785
ED99 (functional) = 128 mg kg-1 Antimicrobial activity against Trypanosoma brucei infected in NMRI mouse at 128 mg/kg, ip QD for 4 days ChEMBL. 20439607
F (ADMET) = 79 % Oral bioavailability in human ChEMBL. 10891117
GI (ADMET) = 0 % Growth inhibition of mouse J774 cells at 64 uM after 24 hrs by resazurin reduction assay ChEMBL. 23124218
GI (functional) = 46 % Growth inhibition of Trypanosoma cruzi Tulahuen 2 epimastigote at 5 uM after 5 days ChEMBL. 19446929
GI (functional) = 49.9 % Trypanocidal activity against Trypanosoma cruzi Y epimastigotes infected in mouse J774 cells assessed as growth inhibition of parasite at 5 uM measured on day 5 ChEMBL. 25008454
GI (functional) = 91.57 % Growth inhibition of epimastigote form of Trypanosoma cruzi CL-B5 at 64 uM after 72 hrs by lacZ reporter gene assay ChEMBL. 23124218
GI (functional) = 93 % Antitrypanosomatid activity against Trypanosoma cruzi Tulahuen 2 epimastigote form at 25 uM ChEMBL. 16722639
GI (functional) = 93 % Antitrypanosomatid activity against Trypanosoma cruzi Tulahuen 2 epimastigote form at 25 uM ChEMBL. 16722639
GI (functional) = 96.54 % Antimicrobial activity against amastigote stage of Trypanosoma cruzi CL Brener infected in mouse NCTC-929 cells assessed as growth inhibition at 0.5 uM after 7 days by beta-galactosidase reporter gene assay ChEMBL. 24461296
GI (functional) = 100 % Growth inhibition of Trypanosoma cruzi epimastigotes Tulahuen 2 at 25 uM ChEMBL. 18083035
GI (functional) = 100 % Percent inhibition of growth against Trypanosoma cruzi epimastigotes, Y strain at concentration 4 microg/ml (13-17 microM) ChEMBL. No reference
GI (functional) = 100 % Growth inhibition of Trypanosoma cruzi epimastigotes Tulahuen 2 at 25 uM ChEMBL. 18083035
GI (functional) = 100 % Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 at 25 uM after 5 days ChEMBL. 17709156
GI (functional) = 100 % Growth inhibition of Trypanosoma cruzi CL-Brener clone epimastigotes infected in mouse blood at 25 uM measured on day 5 postinfection by Brener method ChEMBL. 18762357
GI (functional) = 100 % Antitrypanosomal activity against epimastigotes of Trypanosoma cruzi Tulahuen 2 at 25 uM relative to control ChEMBL. 18547811
GI (functional) = 100 % Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 assessed as inhibition of epimastigotes growth at 50 uM ChEMBL. 20116908
GI (functional) = 100 % Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes assessed as inhibition of parasite growth at 25 uM relative to control ChEMBL. 20634064
GI (functional) = 100 % Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes assessed as growth inhibition at 25 uM after 5 days relative to control ChEMBL. 21506600
GI (functional) = 100 % Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes assessed as inhibition of parasite growth at 25 uM after 5 days by spectrophotometric analysis ChEMBL. 22000947
GI (functional) = 100 % Antichagasic activity against epimastigote form of Trypanosoma cruzi Tulahuen 2 assessed as parasite growth inhibition at 25 uM measured on day 5 relative to control ChEMBL. 23811257
GI (functional) = 100 % Antimicrobial activity against benznidazole-resistant epimastigotes of Trypanosoma cruzi Tulahuen 2 assessed as growth inhibition at 25 uM measured on day 5 by spectrophotometry ChEMBL. No reference
GI50 (functional) = 3.78 uM Antitrypanosomal activity against epimastigote stage of Trypanosoma cruzi Y assessed as parasite growth inhibition after 5 days by spectrophotometric analysis ChEMBL. 23644203
IC50 (functional) Antileishmanial activity against Leishmania donovani ChEMBL. 17629327
IC50 (functional) Antiplasmodial activity against Plasmodium falciparum W2 by flow cytometry ChEMBL. 20131843
IC50 (binding) Inhibition of Electrophorus electricus acetylcholinesterase pre-incubated for 20 mins before acetylthiocholine iodide substrate addition by spectrophotometry ChEMBL. 26479031
IC50 (functional) Antitrypanosomal activity against extracellular Trypanosoma cruzi Tulahuen clone C4 ChEMBL. 15497945
IC50 (functional) Antitrypanosomal activity against Trypanosoma cruzi epimastigotes after 3 days ChEMBL. 12880308
IC50 (ADMET) Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measured after 5 mins by spectrophotometric analysis LITERATURE. 27591008
IC50 (functional) 0 Antileishmanial activity against Leishmania donovani ChEMBL. 17629327
IC50 (functional) 0 Cytotoxicity against human MCF7 cells ChEMBL. 17629327
IC50 (functional) 0 Cytotoxicity against human NCI-H460 ChEMBL. 17629327
IC50 (ADMET) 0 Cytotoxicity against human Vero cells by MTT assay ChEMBL. 17629327
IC50 (functional) = 3 ug ml-1 Antitrypanosomal activity against Trypanosoma cruzi ChEMBL. 19007286
IC50 (functional) = 3 ug ml-1 Antitrypanosomal activity against Trypanosoma cruzi Tulahuen infected in mouse 3T3 cells assessed as beta-galactosidase activity after 7 days by chagas bioassay ChEMBL. 20441198
IC50 (functional) uM Inhibitory concentration of the compound in vitro against blood stream trypanosoma brucei brucei AT1 knockout mutant with a non functional P2 transporter; ND is not determined ChEMBL. 16107157
IC50 (functional) uM Cytotoxicity of the compound was determined in macrophages; ND = Not determined ChEMBL. 15203133
IC50 (functional) uM In vitro anti protozoal activity of the compound against Plasmodium falciparum sensitive strain W2; ND = Not determined ChEMBL. 15203133
IC50 (functional) uM In vitro anti protozoal activity of the compound against Trypanosoma brucei strain S427 was determined; ND = Not determined ChEMBL. 15203133
IC50 (functional) uM In vitro anti protozoal activity of the compound against Plasmodium falciparum resistant strain Ghana ;ND = Not determined ChEMBL. 15203133
IC50 (functional) uM In vitro anti protozoal activity of the compound against Leishmania infantum strain MHOM-ET-67/L82 was determined; ND = Not determined ChEMBL. 15203133
IC50 (functional) 0 uM In vitro anti protozoal activity of the compound against Trypanosoma brucei strain S427 was determined; ND = Not determined ChEMBL. 15203133
IC50 (functional) 0 uM In vitro anti protozoal activity of the compound against Leishmania infantum strain MHOM-ET-67/L82 was determined; ND = Not determined ChEMBL. 15203133
IC50 (functional) 0 uM In vitro anti protozoal activity of the compound against Leishmania amazonensis strain MHOM/ET/L82/LV9 was determined; ND = Not determined ChEMBL. 15203133
IC50 (functional) 0 uM Cytotoxicity of the compound was determined in macrophages; ND = Not determined ChEMBL. 15203133
IC50 (functional) 0 uM In vitro anti protozoal activity of the compound against Plasmodium falciparum sensitive strain W2; ND = Not determined ChEMBL. 15203133
IC50 (functional) 0 uM In vitro anti protozoal activity of the compound against Plasmodium falciparum resistant strain Ghana ;ND = Not determined ChEMBL. 15203133
IC50 (functional) 0 uM Cytotoxicity of the compound was determined in MRC-5 cells; ND = Not determined ChEMBL. 15203133
IC50 (functional) = 0.13 uM Trypanocidal activity against bloodstream forms of Trypanosoma brucei brucei Lister 427 clone 221a overexpressing type I nitroreductase assessed as inhibition of proliferation after 3 days by resazurin assay in presence of tetracycline ChEMBL. 25240098
IC50 (functional) = 0.13 uM Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei Lister 427 clone 221a overexpressing tet-inducible NTR in absence of tetracycline after 3 days ChEMBL. 22550999
IC50 (functional) = 0.13 uM Antitrypanosomal activity against tetracycline-induced blood-stream Trypanosoma brucei brucei overexpressing type 1 nitroreductase after 3 days by alamar blue assay ChEMBL. 22023653
IC50 (functional) = 0.23 uM DNDI: Inhibition of Chagas Disease parasite Trypanosoma cruzi (Tulahuen LacZ, Clone C4), in vitro. ChEMBL. No reference
IC50 (functional) = 0.24 uM Antitrypanosomal activity against Trypanosoma cruzi clone Cl-Brener infected in african green monkey Vero cells assessed as growth inhibition after 3 days by luciferase reporter gene assay ChEMBL. 20679506
IC50 (functional) = 0.26 uM Antitrypanosomal activity against Trypanosoma brucei bloodstream form overexpressing nitroreductase assessed as growth inhibition after 3 days by Alamar blue assay ChEMBL. 23031595
IC50 (functional) = 0.39 uM In vitro anti-protozoal parasite activity of the compound against T. cruzi TC-1 ChEMBL. 12781185
IC50 (functional) = 0.39 uM In vitro anti-protozoal parasite activity of the compound against T. cruzi TC-1 ChEMBL. 12781185
IC50 (functional) = 0.39 uM Antitrypanosomal activity against Trypanosoma cruzi Tulahuen CL2 by microdilution method ChEMBL. 15497942
IC50 (functional) = 0.43 uM Antiparasitic activity against blood stream form of Trypanosoma brucei brucei overexpressing type-1 nitroreductase after 3 days by Alamar blue assay in presence of tetracycline ChEMBL. 26344593
IC50 (functional) = 0.43 uM Antimicrobial activity against bloodstream forms of Trypanosoma brucei brucei overexpressing type I nitroreductase assessed as reduction in cell viability after 3 days by alamar blue assay in presence of tetracycline ChEMBL. 26363868
IC50 (functional) = 0.45 uM In vitro anti protozoal activity against Trypanosoma cruzi strain Tulahuen CL2 was determined ChEMBL. 15203133
IC50 (functional) = 0.45 uM In vitro anti protozoal activity against Trypanosoma cruzi strain Tulahuen CL2 was determined ChEMBL. 15203133
IC50 (functional) = 0.45 uM Antitrypanosomal activity against Trypanosoma cruzi Sylvio X-10 amastigotes infected in African green monkey Vero cells assessed as eradication of amastigotes after 72 hrs by Giemsa staining-based assay ChEMBL. 24749923
IC50 (functional) < 0.5 uM Antimicrobial activity against amastigote stage of Trypanosoma cruzi CL Brener infected in mouse NCTC-929 cells assessed as growth inhibition after 7 days by beta-galactosidase reporter gene assay ChEMBL. 24461296
IC50 (functional) = 0.52 uM Antitrypanosomal activity against Trypanosoma cruzi Tulahuen C4 in african green monkey Vero cells after 120 hrs ChEMBL. 18798609
IC50 (functional) = 0.7 uM Trypanocidal activity against nifurtimox-sensitive Trypanosoma cruzi Tulahuen CL2 infected in human MRC5 SV2 cells assessed as parasite growth inhibition after 168 hrs by beta-galactosidase assay ChEMBL. 25199582
IC50 (functional) = 0.869 uM Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei overexpressing type I nitroreductase assessed as inhibition of parasite growth after 3 days by resazurin assay in presence of tetracycline ChEMBL. 27092415
IC50 (functional) = 1.4 uM Antiparasitic activity against Trypanosoma cruzi 320I04 intracellular amastigotes infected in african green monkey Vero cells after 72 hrs ChEMBL. 19321339
IC50 (functional) = 1.5 uM In vitro inhibitory concentration of the compound against intracellular amastigotes of trypanosoma cruzi in rat skeletal myoblasts incubated for 37 degree C for 4 days ChEMBL. 16107157
IC50 (functional) = 1.5 uM Inhibitory concentration of the compound in vitro against blood stream Trypanosoma brucei rhodesiense incubated for 72 h at 37 degree C ChEMBL. 16107157
IC50 (functional) = 1.7 uM Antitrypanosomal activity against Trypanosoma brucei MITat 427 clone 221a trypomastigotes after 3 days by alamar blue assay ChEMBL. 22248858
IC50 (functional) = 1.71 uM Trypanocidal activity against bloodstream forms of Trypanosoma brucei brucei Lister 427 clone 221a overexpressing type I nitroreductase assessed as inhibition of proliferation after 3 days by resazurin assay in absence of tetracycline ChEMBL. 25240098
IC50 (functional) = 1.71 uM Antitrypanosomal activity against blood-stream Trypanosoma brucei brucei expressing type 1 nitroreductase after 3 days by alamar blue assay in absence of tetracycline ChEMBL. 22023653
IC50 (functional) = 1.71 uM Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei Lister 427 clone 221a overexpressing tet-inducible NTR in presence of tetracycline after 3 days ChEMBL. 22550999
IC50 (functional) = 1.8 uM Antiparasitic activity against Trypanosoma brucei BSF after 3 days by Alamar blue assay ChEMBL. 20028822
IC50 (functional) = 1.8 uM Trypanocidal activity against Trypanosoma cruzi ChEMBL. 23518280
IC50 (functional) = 1.83 uM Antitrypanosomal activity against wild type Trypanosoma brucei bloodstream form assessed as growth inhibition after 3 days by Alamar blue assay ChEMBL. 23031595
IC50 (functional) = 1.9 uM Antitrypanosomal activity against Trypanosoma cruzi Y epimastigote form after 11 days by Trypan blue exclusion method ChEMBL. 19539479
IC50 (functional) = 1.9 uM Antitypanosomal activity against benznidazole-resistant epimastigote stage of Trypanosoma cruzi Y assessed as parasite growth inhibition after 11 days by hemacytometric analysis ChEMBL. No reference
IC50 (functional) = 2 uM Antimicrobial activity against Trypanosoma brucei rhodesiense ChEMBL. 20185316
IC50 (functional) = 2.06 uM Antitrypanosomal activity against Trypanosoma brucei BSF overexpressing NTR gene assessed as growth inhibition after 3 days by Alamar blue assay ChEMBL. 20679506
IC50 (functional) = 2.1 uM Antitrypanosomal activity against Trypanosoma cruzi clone CL-Brener epimastigotes after 14 days by alamar blue assay ChEMBL. 22248858
IC50 (functional) = 2.3 uM Antitrypanosomal activity against Trypanosoma cruzi 320I01 amastigotes infected in african green monkey Vero cells after 5 days by Giemsa staining ChEMBL. 20627590
IC50 (functional) = 2.33 uM Antitrypanosomal activity against Trypanosoma cruzi 320I01 epimastigotes after 72 hrs by haemocytometry ChEMBL. 20627590
IC50 (functional) = 2.7 uM Antitrypanosomal activity against trypomastigotes of Trypanosoma cruzi Y infected in LLC-MK2 cells assessed as parasite motility after 24 hrs ChEMBL. 23167554
IC50 (functional) = 2.8 uM Antimicrobial activity against Trypanosoma cruzi infected in rat L6E9 myoblasts assessed as inhibition of [3H]uracil incorporation by giemsa staining ChEMBL. 20625148
IC50 (functional) = 2.9 uM Trypanocidal activity against bloodstream forms of Trypanosoma brucei brucei Lister 427 clone 221a after 72 hrs by AlamarBlue assay ChEMBL. 24119553
IC50 (functional) = 3.29 uM In vitro for antitrypanosomal activity against Trypanosoma cruzi epimastigote, Ystrain ChEMBL. No reference
IC50 (functional) = 3.4 uM Trypanocidal activity against Trypanosoma brucei brucei after 48 hrs ChEMBL. 16516467
IC50 (functional) = 3.4 uM Antitrypanosomal activity against Trypanosoma cruzi CL-Brener clone epimastigotes infected in mouse blood measured on day 5 postinfection by Brener method ChEMBL. 18762357
IC50 (functional) = 3.4 uM Antitrypanosomal activity against Trypanosoma cruzi CL Brener epimastigotes after 5 days ChEMBL. 19900812
IC50 (functional) = 3.4 uM Antitrypanosomal activity against Trypanosoma brucei brucei ChEMBL. 19715342
IC50 (functional) = 3.4 uM Trypanocidal activity against Trypanosoma brucei brucei after 48 hrs ChEMBL. 16516467
IC50 (functional) = 3.55 uM In vitro for antitrypanosomal activity against Trypanosoma cruzi epimastigote, SC-28 strain ChEMBL. No reference
IC50 (functional) = 3.59 uM Antitrypanosomal activity against epimastigotes of Trypanosoma cruzi Y assessed as parasite growth inhibition after 5 days by spectrophotometric analysis ChEMBL. 23816040
IC50 (functional) = 3.61 uM Growth inhibition of epimastigote form of Trypanosoma cruzi CL-B5 after 72 hrs by lacZ reporter gene assay ChEMBL. 23124218
IC50 (functional) = 3.81 uM In vitro antitrypanosomal activity against Trypanosoma cruzi epimastigote, CL strain ChEMBL. No reference
IC50 (functional) = 3.98 uM Antitrypanosomal activity against wild type bloodstream form of Trypanosoma brucei brucei assessed as inhibition of parasite growth after 3 days by resazurin assay ChEMBL. 27092415
IC50 (functional) = 4 uM Antiparasitic activity against epimastigote stage of Trypanosoma cruzi infected in Vero cells assessed as parasite growth inhibition after 24 hrs by hemocytometery ChEMBL. 25173828
IC50 (functional) = 4.1 uM Inhibitory concentration of the compound against wild-type (427) trypanosoma brucei ChEMBL. 16107157
IC50 (functional) = 4.3 uM Inhibitory concentration of the compound against wild-type (427) with NAC trypanosoma brucei ChEMBL. 16107157
IC50 (functional) = 4.4 uM Anti-trypanosomal activity against Trypanosoma brucei gambiense Feo bloodstream forms assessed as inhibition of parasite growth rate after 72 hrs by resazurin assay ChEMBL. 25089808
IC50 (functional) = 4.41 uM Antimicrobial activity against bloodstream forms of Trypanosoma brucei brucei overexpressing type I nitroreductase assessed as reduction in cell viability after 3 days by alamar blue assay in absence of tetracycline ChEMBL. 26363868
IC50 (functional) = 4.41 uM Antiparasitic activity against blood stream form of Trypanosoma brucei brucei overexpressing type-1 nitroreductase after 3 days by Alamar blue assay in absence of tetracycline ChEMBL. 26344593
IC50 (functional) = 4.5 uM Antitrypanosomal activity against Trypanosoma cruzi tulahuen C4 trypomastigotes infected in african green monkey Vero cells assessed as CPRG cleavage after 120 hrs by microplate reader ChEMBL. 20356752
IC50 (functional) = 4.8 uM Antiparasitic activity against Trypanosoma cruzi 320I04 epimastigotes infected in african green monkey Vero cells after 72 hrs ChEMBL. 19321339
IC50 (functional) = 5.6 uM In vitro inhibitory concentration of the compound against blood stream trypanosoma brucei brucei AT1 wild type incubated for 72 h at 37 degree C ChEMBL. 16107157
IC50 (functional) = 5.7 uM Antitrypanosomal activity against Trypanosoma cruzi Dm28c epimastigotes assessed as inhibition of parasite proliferation after 5 days by hemocytometer analysis ChEMBL. 24561675
IC50 (functional) = 6 uM Antitrypanosomal activity against Trypanosoma cruzi ChEMBL. 17629327
IC50 (functional) = 6 uM Antitrypanosomal activity against Trypanosoma cruzi ChEMBL. 17629327
IC50 (functional) = 6 uM Antitrypanosomal activity against Trypanosoma cruzi epimastigotes ChEMBL. 19606868
IC50 (functional) = 6 uM Antimicrobial activity against Trypanosoma brucei brucei ChEMBL. 20185316
IC50 (functional) = 6.1 uM Antichagasic activity against Trypanosoma cruzi Tulahuen 2 ChEMBL. 21550147
IC50 (functional) = 6.359 uM Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei overexpressing type I nitroreductase assessed as inhibition of parasite growth after 3 days by resazurin assay in absence of tetracycline ChEMBL. 27092415
IC50 (functional) = 6.5 uM Antitrypanosomatid activity against Trypanosoma cruzi Y epimastigote form ChEMBL. 16722639
IC50 (functional) = 6.5 uM Antitrypanosomatid activity against Trypanosoma cruzi Y epimastigotes assessed as reduction of growth after 5 days ChEMBL. 17287123
IC50 (functional) = 6.5 uM Antitrypanosomal activity against Trypanosoma cruzi Y ChEMBL. 17960923
IC50 (functional) = 6.5 uM Antitrypanosomal activity against Trypanosoma cruzi Y epimastigotes after 48 hrs by MTT assay ChEMBL. 17981471
IC50 (functional) = 6.5 uM Antitrypanosomatid activity against Trypanosoma cruzi Y epimastigote form ChEMBL. 16722639
IC50 (functional) = 6.5 uM Antitrypanosomatid activity against Trypanosoma cruzi Y epimastigotes assessed as reduction of growth after 5 days ChEMBL. 17287123
IC50 (functional) = 6.5 uM Antitrypanosomal activity against Trypanosoma cruzi Y ChEMBL. 17960923
IC50 (functional) = 6.5 uM Antitrypanosomal activity against Trypanosoma cruzi Y epimastigotes after 48 hrs by MTT assay ChEMBL. 17981471
IC50 (functional) = 6.5 uM Antitrypanosomal activity against Trypanosoma cruzi Y epimastigotes ChEMBL. 18068272
IC50 (functional) = 7 uM Trypanocidal activity against Trypanosoma cruzi Y epimastigotes infected in mouse J774 cells assessed as growth inhibition of parasite measured on day 5 ChEMBL. 25008454
IC50 (functional) = 7.7 uM Antitrypanosomatid activity against Trypanosoma cruzi Tulahuen 2 epimastigote form ChEMBL. 16722639
IC50 (functional) = 7.7 uM Antitrypanosomatid activity against Trypanosoma cruzi Tulahuen 2 epimastigotes assessed as reduction of growth after 5 days ChEMBL. 17287123
IC50 (functional) = 7.7 uM Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 ChEMBL. 17960923
IC50 (functional) = 7.7 uM Growth inhibition of Trypanosoma cruzi epimastigotes Tulahuen 2 ChEMBL. 18083035
IC50 (functional) = 7.7 uM Antitrypanosomatid activity against Trypanosoma cruzi Tulahuen 2 epimastigote form ChEMBL. 16722639
IC50 (functional) = 7.7 uM Antitrypanosomatid activity against Trypanosoma cruzi Tulahuen 2 epimastigotes assessed as reduction of growth after 5 days ChEMBL. 17287123
IC50 (functional) = 7.7 uM Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 ChEMBL. 17960923
IC50 (functional) = 7.7 uM Growth inhibition of Trypanosoma cruzi epimastigotes Tulahuen 2 ChEMBL. 18083035
IC50 (functional) = 7.7 uM Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 ChEMBL. 19110434
IC50 (functional) = 7.7 uM Antitrypanosomal activity against epimastigotes of Trypanosoma cruzi Tulahuen 2 ChEMBL. 18547811
IC50 (functional) = 7.7 uM Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes after 5 days ChEMBL. 19168363
IC50 (functional) = 7.7 uM Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes ChEMBL. 18068272
IC50 (functional) = 7.7 uM Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes assessed as parasite growth inhibition after 5 days ChEMBL. 19837489
IC50 (functional) = 7.7 uM Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 assessed as inhibition of epimastigotes growth ChEMBL. 20116908
IC50 (functional) = 7.7 uM Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes ChEMBL. 20634064
IC50 (functional) = 7.7 uM Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes assessed as inhibition of parasite growth after 5 days by spectrophotometric analysis ChEMBL. 22000947
IC50 (functional) = 7.7 uM Trypanosomicidal activity against axenic epimastigote stage of Trypanosoma cruzi Tulahuen 2 assessed as growth inhibition ChEMBL. 23202852
IC50 (functional) = 7.7 uM Trypanocidal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes after 5 days ChEMBL. 26750255
IC50 (functional) = 7.7 uM Antichagasic activity against epimastigote form of Trypanosoma cruzi Tulahuen 2 assessed as parasite growth inhibition measured on day 5 ChEMBL. 23811257
IC50 (functional) = 8.5 uM Antitrypanosomatid activity against Trypanosoma cruzi CL Brener epimastigote form ChEMBL. 16722639
IC50 (functional) = 8.5 uM Antitrypanosomatid activity against Trypanosoma cruzi CL Brener epimastigotes assessed as reduction of growth after 5 days ChEMBL. 17287123
IC50 (functional) = 8.5 uM Antitrypanosomal activity against Trypanosoma cruzi CL Brener ChEMBL. 17960923
IC50 (functional) = 8.5 uM Antitrypanosomatid activity against Trypanosoma cruzi CL Brener epimastigote form ChEMBL. 16722639
IC50 (functional) = 8.5 uM Antitrypanosomatid activity against Trypanosoma cruzi CL Brener epimastigotes assessed as reduction of growth after 5 days ChEMBL. 17287123
IC50 (functional) = 8.5 uM Antitrypanosomal activity against Trypanosoma cruzi CL Brener ChEMBL. 17960923
IC50 (functional) = 8.5 uM Antitrypanosomal activity against epimastigotes of Trypanosoma cruzi CL Brener ChEMBL. 18547811
IC50 (functional) = 8.5 uM Antitrypanosomal activity against Trypanosoma cruzi CL Brener epimastigotes ChEMBL. 18068272
IC50 (functional) = 8.5 uM Antitrypanosomal activity against Trypanosoma cruzi CL Brener epimastigotes assessed as parasite viability after 5 days by MTT assay ChEMBL. 19837489
IC50 (functional) = 8.5 uM Antitrypanosomal activity against Trypanosoma cruzi Y trypomastigote form after 24 hrs by Trypan blue exclusion method ChEMBL. 19539479
IC50 (functional) = 8.5 uM Antitypanosomal activity against benznidazole-resistant trypomastigote stage of Trypanosoma cruzi Y assessed as parasite growth inhibition after 24 hr by hemacytometric analysis ChEMBL. No reference
IC50 (functional) = 8.6 uM Concentration required to inhibit proliferation of the epimastigote form of T. cruzi ChEMBL. 9554887
IC50 (functional) = 8.6 uM Concentration required to inhibit proliferation of the epimastigote form of T. cruzi ChEMBL. 9554887
IC50 (functional) = 9.5 uM Growth inhibition of Trypanosoma cruzi Tulahuen epimastigotes assessed as drug level causing decrease in growth constant ChEMBL. 18029184
IC50 (functional) = 9.5 uM Growth inhibition of Trypanosoma cruzi Tulahuen epimastigotes assessed as drug level causing decrease in growth constant ChEMBL. 18029184
IC50 (functional) = 10 uM Antitrypanosomal activity against Trypanosoma cruzi Tulahuen C4 in vero cells assessed as intracellular growth inhibition of trypomastigote by beta-galactosidase reporter gene assay ChEMBL. 18715036
IC50 (functional) = 10.67 uM Antitrypanosomal activity against epimastigote stage of Trypanosoma cruzi Tulahuen CL98 after 48 hrs by hemocytometry ChEMBL. 27345756
IC50 (functional) = 11 uM Antitrypanosomal activity against intracellular Trypanosoma cruzi Tulahuen clone C4 assessed as cleavage of chlorophenol red-beta-D-galactosidase ChEMBL. 15497945
IC50 (functional) = 11 uM Antitrypanosomal activity against Trypanosoma cruzi Tulahuen clone C4 trypomastigotes in HFF after 7 days by beta-galactosidase reporter gene assay ChEMBL. 12880308
IC50 (functional) = 11 uM Antitrypanosomal activity against Trypanosoma cruzi Tulahuen C4 infected in african green monkey Vero cells assessed as growth inhibition of trypomastigotes by beta-galactosidase reporter gene assay ChEMBL. 17067146
IC50 (functional) = 11.4 uM Inhibitory concentration of the compound against wild-type (427) trypanosoma brucei ChEMBL. 16107157
IC50 (ADMET) = 12 uM Cytotoxicity against human HeLa cells after 24 hrs by MTT assay ChEMBL. 19168363
IC50 (functional) = 12.84 uM Anti-trypanosomal activity against Trypanosoma cruzi Y epimastigote forms assessed as inhibition of parasite growth after 72 hrs by microplate reader based assay ChEMBL. 25899337
IC50 (functional) = 13.5 uM Antitrypanosomal activity against Trypanosoma cruzi at 16.9 uM ChEMBL. 19161344
IC50 (functional) = 13.5 uM Antiparasitic activity against Trypanosoma cruzi Tulahuen C4 infected african green monkey Vero cells expressing beta-galctosidase after 5 days ChEMBL. 20030365
IC50 (functional) = 21.05 uM Trypanocidal activity against epimastigote stage of Trypanosoma cruzi infected in african green monkey Vero cells assessed as cell viability after 24 hrs by MTT assay ChEMBL. 25127463
IC50 (ADMET) = 64.8 uM Cytotoxicity against human THP1 cells after 6 days by Alamar blue assay ChEMBL. 20028822
IC50 (functional) = 68 uM Inhibitory concentration of the compound in vitro against intracellular amastigotes of Leishmania donovani in rat skeletal myoblasts incubated for 96 h at 27 degree C ChEMBL. 16107157
IC50 (ADMET) > 100 uM Cytotoxicity against human THP1 cells by AlamarBlue assay ChEMBL. 24119553
IC50 (functional) > 200 uM Cytotoxicity against J774.1 cell line after 48 hrs ChEMBL. 16516467
IC50 (functional) > 200 uM Cytotoxicity against J774.1 cell line after 48 hrs ChEMBL. 16516467
IC50 = 263.44 uM Cytotoxicity against mouse RAW264 LITERATURE. 27908757
IC50 (ADMET) = 280.48 uM Cytotoxicity against mouse J774 cells after 48 hrs by MTT assay ChEMBL. 23816040
IC50 (ADMET) = 316 uM Cytotoxicity against mouse J774 cells assessed as cell viability after 48 hrs by MTT assay ChEMBL. 25008454
IC50 (ADMET) = 316 uM Cytotoxicity against mouse J774 cells assessed as cell viability after 48 hrs by MTT assay ChEMBL. 23811257
IC90 (functional) = 25 ug Antitrypanosomal activity against Trypanosoma cruzi Z2 after 48 hrs ChEMBL. 1919589
IC90 (functional) = 25 ug Antitrypanosomal activity against Trypanosoma cruzi C8 CL1 after 48 hrs ChEMBL. 1919589
IC90 (functional) = 25 ug Antitrypanosomal activity against Trypanosoma cruzi Y after 48 hrs ChEMBL. 1919589
IC90 (functional) = 25 ug Antitrypanosomal activity against Trypanosoma cruzi TeCL2 after 48 hrs ChEMBL. 1919589
IC90 (functional) = 25 ug Antitrypanosomal activity against Trypanosoma cruzi R107 after 48 hrs ChEMBL. 1919589
IC90 (functional) = 25 ug Antitrypanosomal activity against Trypanosoma cruzi A99CL7 after 48 hrs ChEMBL. 1919589
IC90 (functional) = 25 ug Antitrypanosomal activity against Trypanosoma cruzi Tulahuen after 48 hrs ChEMBL. 1919589
IC90 (functional) = 50 ug Antitrypanosomal activity against Trypanosoma cruzi MIL4CL10 after 48 hrs ChEMBL. 1919589
IC90 (functional) = 50 ug Antitrypanosomal activity against Trypanosoma cruzi Z1 after 48 hrs ChEMBL. 1919589
IC90 (functional) = 50 ug Antitrypanosomal activity against Trypanosoma cruzi Z2CL4 after 48 hrs ChEMBL. 1919589
IC90 (functional) = 50 ug Antitrypanosomal activity against Trypanosoma cruzi 13379 CL8 after 48 hrs ChEMBL. 1919589
IC90 (functional) = 50 ug Antitrypanosomal activity against Trypanosoma cruzi 9280CL1 after 48 hrs ChEMBL. 1919589
IC90 (functional) = 50 ug Antitrypanosomal activity against Trypanosoma cruzi M6241CL6 after 48 hrs ChEMBL. 1919589
IC90 (functional) > 100 ug Antitrypanosomal activity against Trypanosoma cruzi 13379 CL3 after 48 hrs ChEMBL. 1919589
IC90 (functional) = 100 ug Antitrypanosomal activity against Trypanosoma cruzi 13379 CL5 after 48 hrs ChEMBL. 1919589
IC90 (functional) > 100 ug Antitrypanosomal activity against Trypanosoma cruzi 13379 CL6 after 48 hrs ChEMBL. 1919589
IC90 (functional) = 100 ug Antitrypanosomal activity against Trypanosoma cruzi A98CL5 after 48 hrs ChEMBL. 1919589
IC90 (functional) = 100 ug Antitrypanosomal activity against Trypanosoma cruzi CL after 48 hrs ChEMBL. 1919589
IC90 (functional) = 100 ug Antitrypanosomal activity against Trypanosoma cruzi 27R27CL1 after 48 hrs ChEMBL. 1919589
IC90 (functional) = 100 ug Antitrypanosomal activity against Trypanosoma cruzi 31R16CL1 after 48 hrs ChEMBL. 1919589
IC90 (functional) = 25 ug ml-1 Antitrypanosomal activity against Trypanosoma cruzi Tulahuen ChEMBL. No reference
IC90 (functional) = 0.82 uM DNDI: Inhibition of Chagas Disease parasite Trypanosoma cruzi (Tulahuen LacZ, Clone C4), in vitro. ChEMBL. No reference
IC90 (functional) = 9.06 uM Antitrypanosomal activity against Trypanosoma cruzi 320I01 amastigotes infected in african green monkey Vero cells after 5 days by Giemsa staining ChEMBL. 20627590
IC90 (functional) = 11 uM Antiparasitic activity against Trypanosoma cruzi 320I04 intracellular amastigotes infected in african green monkey Vero cells after 72 hrs ChEMBL. 19321339
IC90 (functional) = 17 uM Antiparasitic activity against Trypanosoma cruzi 320I04 epimastigotes infected in african green monkey Vero cells after 72 hrs ChEMBL. 19321339
IC90 (functional) = 23.41 uM Antitrypanosomal activity against Trypanosoma cruzi 320I01 epimastigotes after 72 hrs by haemocytometry ChEMBL. 20627590
ID50 (functional) = 3.4 mM Antitrypanosomal activity against Trypanosoma cruzi Colombiana after 5 days by MTT assay ChEMBL. 19616875
ID50 (functional) = 4.9 mM Antitrypanosomal activity against Trypanosoma cruzi CL Brener epimastigotes after 5 days by MTT assay ChEMBL. 19616875
ID50 (functional) = 9.7 mM Antitrypanosomal activity against Trypanosoma cruzi Y epimastigotes after 5 days by MTT assay ChEMBL. 19616875
ID50 (ADMET) = 316000 nM Cytotoxicity against mouse J774 cells ChEMBL. 21506600
ID50 (functional) = 3.4 uM In vitro inhibitory dose against epimastigote form of Trypanosoma cruzi Brener strain ChEMBL. 15203172
ID50 (functional) = 3.4 uM In vitro inhibitory dose against epimastigote form of Trypanosoma cruzi Brener strain ChEMBL. 15203172
ID50 (functional) = 3.4 uM Antitrypanosomal activity against Trypanosoma cruzi Colombiana epimastigotes assessed as cell death after 2 days by MTT assay ChEMBL. 21506600
ID50 (functional) = 4.9 uM Antitrypanosomal activity against Trypanosoma cruzi CL Brener assessed as parasite viability after 5 days by MTT assay ChEMBL. 18706821
ID50 (functional) = 4.9 uM Antitrypanosomal activity against Trypanosoma cruzi CL Brener clone epimastigotes assessed as cell death after 2 days by MTT assay ChEMBL. 21506600
ID50 (functional) = 7.7 uM In vitro inhibitory dose against epimastigote form of Trypanosoma cruzi Tulahuen strain ChEMBL. 15203172
ID50 (functional) = 7.7 uM In vitro inhibitory dose against epimastigote form of Trypanosoma cruzi Tulahuen strain ChEMBL. 15203172
ID50 (functional) = 7.7 uM Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 after 5 days ChEMBL. 17709156
ID50 (functional) = 7.7 uM Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 assessed as inhibition of epimastigotes growth after 5 days by MTT assay relative to control ChEMBL. 18706821
ID50 (functional) = 7.7 uM Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes assessed as inhibition of parasite growth after 5 days ChEMBL. 19616875
ID50 (functional) = 7.7 uM Antitrypanosomal activity against epimastigote stage of Trypanosoma cruzi Tulahuen 2 after 5 days relative to untreated control ChEMBL. No reference
ID50 (functional) = 9.7 uM Antitrypanosomal activity against Trypanosoma cruzi Y assessed as parasite viability after 5 days by MTT assay ChEMBL. 18706821
ID50 (functional) = 9.7 uM Antitrypanosomal activity against Trypanosoma cruzi Y epimastigotes assessed as cell death after 2 days by MTT assay ChEMBL. 21506600
ID50 (ADMET) > 300 uM Cytotoxicity against human THP1 cells after 48 hrs ChEMBL. 17709156
ID50 (ADMET) = 316 uM Cytotoxicity against mouse J774 cells after 48 hrs by MTT assay ChEMBL. 19811923
ID50 (ADMET) = 316 uM Cytotoxicity against mouse J774 cells after 48 hrs by MTT assay ChEMBL. 20163894
ID50 (ADMET) = 346 uM Cytotoxicity against mouse J774 cells ChEMBL. 19616875
ID50 (functional) = 7700 uM Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes assessed as growth inhibition after 5 days ChEMBL. 21506600
Inhibition (functional) Antimicrobial activity against Trypanosoma brucei NfxR1 infected in NMRI mouse assessed as effect on parasitemia level at 100 mg/kg, ip QD for 3 days measured in 6 days by neubuaer hemocytometry ChEMBL. 20439607
Inhibition (binding) Inhibition of Trypanosoma brucei rhodesiense rhodesain after 12 hrs by fluorescence spectroscopy-based on-bead assay ChEMBL. 19715342
Inhibition (binding) Inhibition of human liver cathepsin B at 100 uM ChEMBL. 19715342
Inhibition (binding) Inhibition of Trypanosoma brucei rhodesiense recombinant rhodesain at 100 uM ChEMBL. 19715342
Inhibition (binding) Compound was evaluated for the inhibition of human FECH at 10uM MMV_PBOX. No reference
Inhibition (functional) % Inhibitory activity of the compound against proliferationof HTLV-1 transformed cell lines (HUT-102) at 10 microM; ND = Not determined ChEMBL. 15203133
Inhibition (functional) 0 % Inhibitory activity of the compound against proliferationof HTLV-1 transformed cell lines (HUT-102) at 10 microM; ND = Not determined ChEMBL. 15203133
Inhibition (functional) = 13.24 % Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 1 mg/mL after incubation for 98 hr ChEMBL. 15713399
Inhibition (functional) = 13.24 % Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 1 mg/mL after incubation for 98 hr ChEMBL. 15713399
Inhibition (functional) = 17.39 % Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 1 mg/mL after incubation for 24 hr ChEMBL. 15713399
Inhibition (functional) = 17.39 % Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 1 mg/mL after incubation for 24 hr ChEMBL. 15713399
Inhibition (functional) = 19.64 % Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 1 mg/mL after incubation for 72 hr ChEMBL. 15713399
Inhibition (functional) = 19.64 % Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 1 mg/mL after incubation for 72 hr ChEMBL. 15713399
Inhibition (functional) = 20 % Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 1 mg/mL after incubation for 48 hr ChEMBL. 15713399
Inhibition (functional) = 20 % Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 1 mg/mL after incubation for 48 hr ChEMBL. 15713399
Inhibition (functional) = 99 % Antitrypanosomal activity against Trypanosoma cruzi infected in albino CF1 mouse assessed as reduction in number of parasites in blood at 104 mg/kg/day, intramuscular treatment started on day 10 of infection up to day 14 ChEMBL. 69024
Inhibition (functional) = 100 % The compound was tested in vitro for antitrypanosomal activity against Trypanosoma cruzi epimastigotes at a dose of 25 microM ChEMBL. 10354402
Inhibition (functional) = 100 % Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 10 mg/mL after incubation for 98 hr ChEMBL. 15713399
Inhibition (functional) = 100 % Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 100 mg/mL after incubation for 98 hr ChEMBL. 15713399
Inhibition (functional) = 100 % Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 10 mg/mL after incubation for 24 hr ChEMBL. 15713399
Inhibition (functional) = 100 % Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 100 mg/mL after incubation for 24 hr ChEMBL. 15713399
Inhibition (functional) = 100 % Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 10 mg/mL after incubation for 48 hr ChEMBL. 15713399
Inhibition (functional) = 100 % Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 100 mg/mL after incubation for 48 hr ChEMBL. 15713399
Inhibition (functional) = 100 % Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 10 mg/mL after incubation for 72 hr ChEMBL. 15713399
Inhibition (functional) = 100 % Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 100 mg/mL after incubation for 72 hr ChEMBL. 15713399
Inhibition (functional) = 100 % The compound was tested in vitro for antitrypanosomal activity against Trypanosoma cruzi epimastigotes at a dose of 25 microM ChEMBL. 10354402
Inhibition (functional) = 100 % Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 10 mg/mL after incubation for 98 hr ChEMBL. 15713399
Inhibition (functional) = 100 % Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 100 mg/mL after incubation for 98 hr ChEMBL. 15713399
Inhibition (functional) = 100 % Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 10 mg/mL after incubation for 24 hr ChEMBL. 15713399
Inhibition (functional) = 100 % Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 100 mg/mL after incubation for 24 hr ChEMBL. 15713399
Inhibition (functional) = 100 % Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 10 mg/mL after incubation for 48 hr ChEMBL. 15713399
Inhibition (functional) = 100 % Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 100 mg/mL after incubation for 48 hr ChEMBL. 15713399
Inhibition (functional) = 100 % Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 10 mg/mL after incubation for 72 hr ChEMBL. 15713399
Inhibition (functional) = 100 % Percent of growth inhibition of Trypanosoma cruzi (Y strain) epimastigote forms at compound concentration of 100 mg/mL after incubation for 72 hr ChEMBL. 15713399
Inhibition (functional) = 100 % Trypanocidal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes at 25 uM after 5 days ChEMBL. 26750255
Inhibition (functional) = 100 % Antiparasitic activity against epimastigote stage of Trypanosoma cruzi assessed as growth inhibition at 50 uM ChEMBL. No reference
Ki (binding) Inhibition of Trypanosoma brucei rhodesiense recombinant rhodesain ChEMBL. 19715342
Ki (binding) Inhibition of Trypanosoma brucei rhodesiense recombinant rhodesain by standard fluorescence assay ChEMBL. 20131843
Ki (binding) Inhibition of Trypanosoma brucei rhodesiense rhodesain ChEMBL. 16516467
Ki (binding) Inhibition of human liver cathepsin B ChEMBL. 19715342
Ki (binding) 0 Inhibition of Trypanosoma brucei rhodesiense rhodesain ChEMBL. 16516467
LC50 (functional) Antimicrobial activity against Leishmania mexicana MHOM/BZ/61/M379 after 24 hrs by haemocytometry ChEMBL. 25899334
LC50 (functional) = 8.5 ug ml-1 Trypanocidal activity against epimastigote forms of Trypanosoma cruzi Queretaro after 24 hrs ChEMBL. 25238291
LC50 (functional) = 310 uM Antimicrobial activity against bloodstream trypomastigote stage of Trypanosoma cruzi INC-5 after 24 hrs by Brener method ChEMBL. 25899334
LD50 (ADMET) > 800 mg kg-1 Acute toxicity in ip dosed CFW mouse administered daily for 5 days ChEMBL. 406399
log1/IC50 (functional) = 4.89 Anti-trypanosomal activity against Trypanosoma cruzi Y epimastigote forms assessed as inhibition of parasite growth after 72 hrs by microplate reader based assay ChEMBL. 25899337
log1/IC50 (functional) = 5.14 Anti-trypanosomal activity against Trypanosoma cruzi Bug 2149 cl10 epimastigote forms assessed as inhibition of parasite growth after 72 hrs by microplate reader based assay ChEMBL. 25899337
log1/IC50 (functional) = 5.22 Anti-trypanosomal activity against Trypanosoma cruzi Silvio X10 cl1 epimastigote forms assessed as inhibition of parasite growth after 72 hrs by microplate reader based assay ChEMBL. 25899337
logD (ADMET) = 0.08 Partition coefficient (logD6.5) ChEMBL. 10891117
MIC (functional) = 15.2 ug ml-1 Antimicrobial activity against Trypanosoma brucei NfxR1 ChEMBL. 20439607
MIC (functional) = 7.7 uM Antimicrobial activity against benznidazole-resistant epimastigotes of Trypanosoma cruzi Tulahuen 2 assessed as growth inhibition measured on day 5 by spectrophotometry ChEMBL. No reference
MIC (functional) = 200 uM Trypanocidal activity against Trypanosoma brucei brucei after 48 hrs ChEMBL. 16516467
MIC (functional) = 200 uM Trypanocidal activity against Trypanosoma brucei brucei after 48 hrs ChEMBL. 16516467
MST (functional) = 60 day Antiprotozoal activity against Trypanosoma cruzi BH infected in CFW mouse assessed as increase in host mean survival time at 100 mg/kg, ip administered daily for 5 days starting 4 hrs post-parasite infection (Rvb = 14 +/- 1 days) ChEMBL. 406399
Myoblasts with parasites (functional) = 6.75 % Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 72 hr at the concentration of 5.0 (microg/mL) ChEMBL. 9554887
Myoblasts with parasites (functional) = 6.75 % Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 72 hr at the concentration of 5.0 (microg/mL) ChEMBL. 9554887
Myoblasts with parasites (functional) = 7 % Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 72 hr at the concentration of 2.5 (microg/mL) ChEMBL. 9554887
Myoblasts with parasites (functional) = 7 % Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 72 hr at the concentration of 2.5 (microg/mL) ChEMBL. 9554887
Myoblasts with parasites (functional) = 12.5 % Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 72 hr at the concentration of 1.0 (microg/mL) ChEMBL. 9554887
Myoblasts with parasites (functional) = 12.5 % Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 72 hr at the concentration of 1.0 (microg/mL) ChEMBL. 9554887
Myoblasts with parasites (functional) = 13.5 % Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 48 hr at the concentration of 2.5 (microg/mL) ChEMBL. 9554887
Myoblasts with parasites (functional) = 13.5 % Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 48 hr at the concentration of 5.0 (microg/mL) ChEMBL. 9554887
Myoblasts with parasites (functional) = 13.5 % Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 48 hr at the concentration of 2.5 (microg/mL) ChEMBL. 9554887
Myoblasts with parasites (functional) = 13.5 % Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 48 hr at the concentration of 5.0 (microg/mL) ChEMBL. 9554887
Myoblasts with parasites (functional) = 14 % Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 48 hr at the concentration of 1.0 (microg/mL) ChEMBL. 9554887
Myoblasts with parasites (functional) = 14 % Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 48 hr at the concentration of 1.0 (microg/mL) ChEMBL. 9554887
Myoblasts with parasites (functional) = 16.25 % Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 48 hr (absence of compound) ChEMBL. 9554887
Myoblasts with parasites (functional) = 16.25 % Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 48 hr (absence of compound) ChEMBL. 9554887
Myoblasts with parasites (functional) = 20 % Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 72 hr (absence of compound) ChEMBL. 9554887
Myoblasts with parasites (functional) = 20 % Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 72 hr (absence of compound) ChEMBL. 9554887
Myoblasts with parasites (functional) = 34.5 % Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 24 h (absence of compound) ChEMBL. 9554887
Myoblasts with parasites (functional) = 34.5 % Growth inhibition of the intracellular T.cruzi was measured by counting percentage of myoblasts with T. cruzi parasite after 24 h (absence of compound) ChEMBL. 9554887
P2 uptake (binding) In vitro inhibitory concentration against P2 aminopurine transporter of trypanosoma brucei brucei 427 adenosine (0.5 uM) uptake in presence of 1 mM inosine; ND=not determined ChEMBL. 16107157
pKa ND 0 Ionization constant (pKa) ChEMBL. 10891117
R (functional) = 9.25 % Growth inhibition of the intracellular T. cruzi was measured by no. of parasites per 100 myoblasts (T. cruzi ) after 72 hr at the concentration of 5.0 (microg/mL) ChEMBL. 9554887
R (functional) = 9.25 % Growth inhibition of the intracellular T. cruzi was measured by no. of parasites per 100 myoblasts (T. cruzi ) after 72 hr at the concentration of 5.0 (microg/mL) ChEMBL. 9554887
R (functional) = 20.25 % Growth inhibition of the intracellular T. cruzi was measured by no. of parasites per 100 myoblasts (T. cruzi ) after 72 hr at the concentration of 2.5 (microg/mL) ChEMBL. 9554887
R (functional) = 20.25 % Growth inhibition of the intracellular T. cruzi was measured by no. of parasites per 100 myoblasts (T. cruzi ) after 72 hr at the concentration of 2.5 (microg/mL) ChEMBL. 9554887
R (functional) = 27 % Growth inhibition of the intracellular T. cruzi was measured by no. of parasites per 100 myoblasts (T. cruzi ) after 48 hr at the concentration of 5.0 (microg/mL) ChEMBL. 9554887
R (functional) = 27 % Growth inhibition of the intracellular T. cruzi was measured by no. of parasites per 100 myoblasts (T. cruzi ) after 48 hr at the concentration of 5.0 (microg/mL) ChEMBL. 9554887
R (functional) = 34.75 % Growth inhibition of the intracellular T. cruzi was measured by no. of parasites per 100 myoblasts (T. cruzi ) after 48 hr at the concentration of 2.5 (microg/mL) ChEMBL. 9554887
R (functional) = 34.75 % Growth inhibition of the intracellular T. cruzi was measured by no. of parasites per 100 myoblasts (T. cruzi ) after 48 hr at the concentration of 2.5 (microg/mL) ChEMBL. 9554887
R (functional) = 64.5 % Growth inhibition of the intracellular T. cruzi was measured by no. of parasites per 100 myoblasts (T. cruzi ) after 48 hr at the concentration of 1.0 (microg/mL) ChEMBL. 9554887
R (functional) = 64.5 % Growth inhibition of the intracellular T. cruzi was measured by no. of parasites per 100 myoblasts (T. cruzi ) after 48 hr at the concentration of 1.0 (microg/mL) ChEMBL. 9554887
R (functional) = 70.5 % Growth inhibition of the intracellular T. cruzi was measured by no. of parasites per 100 myoblasts (T. cruzi ) after 72 hr at the concentration of 1.0 (microg/mL) ChEMBL. 9554887
R (functional) = 70.5 % Growth inhibition of the intracellular T. cruzi was measured by no. of parasites per 100 myoblasts (T. cruzi ) after 72 hr at the concentration of 1.0 (microg/mL) ChEMBL. 9554887
R (functional) = 80.25 % Growth inhibition of the intracellular T. cruzi was measured by counting no. of parasites per 100 myoblasts (T. cruzi ) after 24 h (absence of compound) ChEMBL. 9554887
R (functional) = 80.25 % Growth inhibition of the intracellular T. cruzi was measured by counting no. of parasites per 100 myoblasts (T. cruzi ) after 24 h (absence of compound) ChEMBL. 9554887
R (functional) = 155 % Growth inhibition of the intracellular T. cruzi was measured by counting no. of parasites per 100 myoblasts (T. cruzi ) after 48 hr (absence of compound) ChEMBL. 9554887
R (functional) = 155 % Growth inhibition of the intracellular T. cruzi was measured by counting no. of parasites per 100 myoblasts (T. cruzi ) after 48 hr (absence of compound) ChEMBL. 9554887
R (functional) = 321 % Growth inhibition of the intracellular T. cruzi was measured by no. of parasites per 100 myoblasts (T. cruzi ) after 72 hr (absence of compound) ChEMBL. 9554887
R (functional) = 321 % Growth inhibition of the intracellular T. cruzi was measured by no. of parasites per 100 myoblasts (T. cruzi ) after 72 hr (absence of compound) ChEMBL. 9554887
Ratio EC50 (functional) = 8 Selectivity ratio of EC50 for Trypanosoma brucei NfxR1 to EC50 for Trypanosoma brucei ChEMBL. 20439607
Ratio EC50 (functional) = 8 Selectivity ratio of EC50 for Trypanosoma brucei NfxR2 to EC50 for Trypanosoma brucei ChEMBL. 20439607
Ratio IC50 (functional) = 1.5 Ratio of nifurtimox IC50 to compound IC50 for axenic epimastigote stage of Trypanosoma cruzi Tulahuen 2 ChEMBL. 23202852
Ratio IC50 (functional) = 2 Selectivity index, ratio of IC50 for Trypanosoma cruzi Silvio X10 cl1 to IC50 for Trypanosoma cruzi Y ChEMBL. 25899337
Ratio IC50 (functional) = 2 Selectivity index, ratio of IC50 for Trypanosoma cruzi Bug 2149 cl10 to IC50 for Trypanosoma cruzi Y ChEMBL. 25899337
Ratio IC50 (functional) = 7 Ratio of IC50 for wild type Trypanosoma brucei bloodstream form to IC50 for Trypanosoma brucei bloodstream form overexpressing nitroreductase ChEMBL. 23031595
Ratio IC50 (functional) = 7.3 Ratio of IC50 for bloodstream form of Trypanosoma brucei brucei overexpressing type I nitroreductase in absence of tetracycline to IC50 for bloodstream form of Trypanosoma brucei brucei overexpressing type I nitroreductase in presence of tetracycline ChEMBL. 27092415
Ratio IC50 (functional) = 10.3 Ratio of IC50 for blood stream form of Trypanosoma brucei brucei overexpressing type-1 nitroreductase in absence of tetracycline to IC50 for blood stream form of Trypanosoma brucei brucei overexpressing type-1 nitroreductase in presence of tetracycline ChEMBL. 26344593
Ratio IC50 (functional) = 10.3 Ratio of IC50 for bloodstream forms of Trypanosoma brucei brucei overexpressing type I nitroreductase in absence of tetracycline to IC50 for bloodstream forms of Trypanosoma brucei brucei overexpressing type I nitroreductase in presence of tetracycline ChEMBL. 26363868
Ratio IC50 (functional) = 11.4 Ratio of nifurtimox IC50 to compound IC50 for amastigote stage of Trypanosoma cruzi Tulahuen C4 ChEMBL. 23202852
Ratio IC50 (functional) = 13 Selectivity ratio of IC50 for Trypanosoma brucei brucei Lister 427 clone 221a overexpressing tet-inducible NTR in presence of tetracycline to IC50 for Trypanosoma brucei brucei overexpressing tet-inducible NTR in absence of tetracyclin ChEMBL. 22550999
Ratio IC50 (functional) = 13 Ratio of IC50 for blood-stream Trypanosoma brucei brucei expressing type 1 nitroreductase in the absence of tetracycline to IC50 for tetracycline-induced blood-stream Trypanosoma brucei brucei overexpressing type 1 nitroreductase ChEMBL. 22023653
Ratio IC50 (functional) = 13.2 Ratio of IC50 for bloodstream forms of Trypanosoma brucei brucei Lister 427 clone 221a overexpressing type I nitroreductase in absence of tetracycline to IC50 for bloodstream forms of Trypanosoma brucei brucei Lister 427 clone 221a overexpressing type I nitroreductase in presence of tetracycline ChEMBL. 25240098
Ratio IC50 (functional) > 58 Selectivity index, IC50 for J774.1/IC50 for Trypanosoma brucei brucei ChEMBL. 16516467
TIME (functional) = 7.3 hr Antimicrobial activity against wild type Trypanosoma brucei assessed as growth doubling time ChEMBL. 20439607
TIME (functional) = 12.8 hr Antimicrobial activity against nifurtimox-resistant Trypanosoma brucei assessed as growth doubling time ChEMBL. 20439607

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19168363
Trypanosoma brucei gambiense 16107157
Trypanosoma cruzi ChEMBL23 12781185
Trypanosoma brucei ChEMBL23 16107157

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Leishmania donovani 22664  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with various inhibitors leads to reduced enzyme activity in vitro; References: 15766869
response to drug (GO:0042493) decreased sensitivity toward (PATO:0001550) epimastigote (BTO:0000409) inferred from gain-of-function mutant phenotype (ECO:0000042) Trypanosoma cruzi 34081  
Annotator: millerja@u.washington.edu Comment: References: 18367671
response to drug (GO:0042493) decreased sensitivity toward (PATO:0001550) epimastigote (BTO:0000409) inferred from gain-of-function mutant phenotype (ECO:0000042) Trypanosoma cruzi 32922  
Annotator: millerja@u.washington.edu Comment: References: 18367671

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

265 literature references were collected for this gene.

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