Detailed information for compound 55808

Basic information

Technical information
  • TDR Targets ID: 55808
  • Name: 1,8-Naphthyridine-3-carboxylic acid, 1,4-dihy dro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-
  • MW: 320.319 | Formula: C15H17FN4O3
  • H donors: 2 H acceptors: 4 LogP: -0.76 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1cc(C(=O)O)c(=O)c2c1nc(N1CCNCC1)c(c2)F
  • InChi: 1S/C15H17FN4O3/c1-2-19-8-10(15(22)23)12(21)9-7-11(16)14(18-13(9)19)20-5-3-17-4-6-20/h7-8,17H,2-6H2,1H3,(H,22,23)
  • InChiKey: IDYZIJYBMGIQMJ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1,8-Naphthyridine-3-carboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-
  • 1,8-Naphthyridine-3-carboxylic acid, 6-fluoro-1,4-dihydro- 4-oxo-7-piperazinyl
  • 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,8-naphthyridine-3-carboxylic acid
  • 1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid
  • 1-ethyl-6-fluoro-4-keto-7-piperazino-1,8-naphthyridine-3-carboxylic acid
  • 1-ethyl-6-fluoro-4-oxo-7-piperazin-4-ium-1-yl-1,8-naphthyridine-3-carboxylate
  • 1-ethyl-6-fluoro-4-oxo-7-(1-piperazin-4-iumyl)-1,8-naphthyridine-3-carboxylate
  • 1-ethyl-6-fluoro-4-keto-7-piperazin-4-ium-1-yl-1,8-naphthyridine-3-carboxylate
  • 1-ethyl-6-fluoro-4-keto-7-piperazin-1-yl-1,8-naphthyridine-3-carboxylic acid
  • 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid
  • 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
  • 74011-58-8
  • AIDS-002306
  • AIDS002306
  • Almitil
  • AT-2266
  • Bactidan
  • BCBcMAP01_000009
  • BPBio1_000491
  • BRN 3628995
  • BSPBio_000445
  • BSPBio_003080
  • C06979
  • CAS-74011-58-8
  • CCRIS 5242
  • CI 919
  • CI-919
  • Comprecin
  • D00310
  • DivK1c_000420
  • E3764_SIGMA
  • Enoram
  • Enoxacin
  • Enoxacin (USAN/INN)
  • Enoxacin [USAN:BAN:INN:JAN]
  • Enoxacine [French]
  • Enoxacino [Spanish]
  • Enoxacinum [Latin]
  • Enoxor
  • IDI1_000420
  • KBio1_000420
  • KBio2_002019
  • KBio2_004587
  • KBio2_007155
  • KBio3_002580
  • KBioGR_000651
  • KBioSS_002019
  • MLS000069645
  • NCGC00016927-01
  • NCGC00023864-04
  • NCGC00023864-03
  • NCI60_009618
  • NINDS_000420
  • NSC 627409
  • NSC 629661
  • NSC629661
  • Oprea1_147866
  • PD 107779
  • PD-107779
  • Penetrex
  • Penetrex (TN)
  • Prestwick0_000353
  • Prestwick1_000353
  • Prestwick2_000353
  • Prestwick3_000353
  • Prestwick_708
  • SMP1_000113
  • SMR000058233
  • SPBio_001802
  • SPBio_002366
  • SPECTRUM1503215
  • Spectrum2_001731
  • Spectrum3_001570
  • Spectrum4_000166
  • Spectrum5_001044
  • Spectrum_001539
  • ST044514

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) Curated by TDR Targets References
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) Curated by TDR Targets References
Homo sapiens lamin A/C Starlite/ChEMBL No references
Leishmania major DNA topoisomerase ii Curated by TDR Targets References
Leishmania major mitochondrial DNA topoisomerase II Curated by TDR Targets References
Escherichia coli DNA gyrase, subunit B References
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Homo sapiens ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 Starlite/ChEMBL References
Escherichia coli DNA gyrase (type II topoisomerase), subunit A References
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127113 All targets in OG5_127113
Giardia lamblia DNA topoisomerase II Get druggable targets OG5_127113 All targets in OG5_127113
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127113 All targets in OG5_127113
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein Get druggable targets OG5_127113 All targets in OG5_127113
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) Get druggable targets OG5_128755 All targets in OG5_128755
Schistosoma mansoni DNA topoisomerase II Get druggable targets OG5_127113 All targets in OG5_127113
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium parvum DNA topoisomerase II Get druggable targets OG5_127113 All targets in OG5_127113
Plasmodium yoelii DNA gyrase subunit a-related Get druggable targets OG5_129568 All targets in OG5_129568
Trichomonas vaginalis ATP synthase alpha subunit mitochondrial, putative Get druggable targets OG5_127061 All targets in OG5_127061
Candida albicans vacuolar ATPase V1 domain subunit B Get druggable targets OG5_127061 All targets in OG5_127061
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB Get druggable targets OG5_128755 All targets in OG5_128755
Leishmania mexicana DNA topoisomerase ii Get druggable targets OG5_127113 All targets in OG5_127113
Trypanosoma cruzi V-type proton ATPase subunit B, putative Get druggable targets OG5_127061 All targets in OG5_127061
Leishmania infantum DNA topoisomerase ii Get druggable targets OG5_127113 All targets in OG5_127113
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus vacuolar ATP synthase subunit b Get druggable targets OG5_127061 All targets in OG5_127061
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Chlamydia trachomatis DNA gyrase subunit B Get druggable targets OG5_127113 All targets in OG5_127113
Plasmodium falciparum DNA topoisomerase 2 Get druggable targets OG5_127113 All targets in OG5_127113
Neospora caninum DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Leishmania infantum vacuolar ATP synthase subunit b, putative Get druggable targets OG5_127061 All targets in OG5_127061
Trypanosoma brucei gambiense DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Candida albicans vacuolar ATPase V1 domain subunit B Get druggable targets OG5_127061 All targets in OG5_127061
Plasmodium vivax DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Trypanosoma brucei DNA topoisomerase ii Get druggable targets OG5_128755 All targets in OG5_128755
Babesia bovis DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127113 All targets in OG5_127113
Trypanosoma cruzi DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Plasmodium berghei V-type proton ATPase subunit B, putative Get druggable targets OG5_127061 All targets in OG5_127061
Leishmania major vacuolar ATP synthase subunit b, putative Get druggable targets OG5_127061 All targets in OG5_127061
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127113 All targets in OG5_127113
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Cryptosporidium hominis vacuolar ATP synthase subunit b Get druggable targets OG5_127061 All targets in OG5_127061
Trypanosoma cruzi Vacuolar proton pump subunit B, putative Get druggable targets OG5_127061 All targets in OG5_127061
Plasmodium vivax DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Onchocerca volvulus DNA topoisomerase 2 homolog Get druggable targets OG5_127113 All targets in OG5_127113
Leishmania mexicana vacuolar ATP synthase subunit b, putative Get druggable targets OG5_127061 All targets in OG5_127061
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Leishmania braziliensis DNA topoisomerase ii Get druggable targets OG5_127113 All targets in OG5_127113
Toxoplasma gondii vacuolar ATP synthase subunit b, putative Get druggable targets OG5_127061 All targets in OG5_127061
Neospora caninum hypothetical protein Get druggable targets OG5_128755 All targets in OG5_128755
Plasmodium knowlesi DNA topoisomerase 2, putative Get druggable targets OG5_127113 All targets in OG5_127113
Echinococcus multilocularis DNA topoisomerase 2 alpha Get druggable targets OG5_127113 All targets in OG5_127113
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Theileria parva DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
Plasmodium yoelii DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Trypanosoma brucei DNA topoisomerase II beta, putative Get druggable targets OG5_127113 All targets in OG5_127113
Trypanosoma congolense Vacuolar proton pump subunit B, putative Get druggable targets OG5_127061 All targets in OG5_127061
Plasmodium vivax DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
Mycobacterium ulcerans DNA gyrase subunit A Get druggable targets OG5_129568 All targets in OG5_129568
Trypanosoma brucei gambiense vacuolar ATP synthase subunit b, putative,v- ATPase B subunit,vacuolar proton pump B subunit Get druggable targets OG5_127061 All targets in OG5_127061
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum DNA gyrase subunit A Get druggable targets OG5_129568 All targets in OG5_129568
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva vacuolar ATP synthase subunit B, putative Get druggable targets OG5_127061 All targets in OG5_127061
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A Get druggable targets OG5_129568 All targets in OG5_129568
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Leishmania major mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Babesia bovis vacuolar ATPase subunit B Get druggable targets OG5_127061 All targets in OG5_127061
Leishmania donovani mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Brugia malayi DNA topoisomerase II, alpha isozyme Get druggable targets OG5_127113 All targets in OG5_127113
Plasmodium berghei DNA topoisomerase 2, putative Get druggable targets OG5_127113 All targets in OG5_127113
Onchocerca volvulus DNA topoisomerase 2 homolog Get druggable targets OG5_127113 All targets in OG5_127113
Mycobacterium ulcerans DNA gyrase subunit B Get druggable targets OG5_128755 All targets in OG5_128755
Plasmodium knowlesi DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127113 All targets in OG5_127113
Leishmania donovani Vacuolar proton pump subunit B, putative Get druggable targets OG5_127061 All targets in OG5_127061
Plasmodium knowlesi V-type proton ATPase subunit B, putative Get druggable targets OG5_127061 All targets in OG5_127061
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127113 All targets in OG5_127113
Leishmania donovani DNA topoisomerase ii Get druggable targets OG5_127113 All targets in OG5_127113
Loa Loa (eye worm) vacuolar ATP synthase subunit B Get druggable targets OG5_127061 All targets in OG5_127061
Plasmodium falciparum V-type proton ATPase subunit B Get druggable targets OG5_127061 All targets in OG5_127061
Plasmodium yoelii V-type ATPase, B subunit Get druggable targets OG5_127061 All targets in OG5_127061
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127113 All targets in OG5_127113
Babesia bovis DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Treponema pallidum DNA gyrase, subunit B (gyrB) Get druggable targets OG5_128755 All targets in OG5_128755
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis vacuolar ATP synthase subunit b, putative Get druggable targets OG5_127061 All targets in OG5_127061
Chlamydia trachomatis DNA gyrase subunit A Get druggable targets OG5_129568 All targets in OG5_129568
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein Get druggable targets OG5_129568 All targets in OG5_129568
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial Get druggable targets OG5_127113 All targets in OG5_127113
Loa Loa (eye worm) TOPoisomerase family member Get druggable targets OG5_127113 All targets in OG5_127113
Neospora caninum V-type ATP synthase beta chain, related Get druggable targets OG5_127061 All targets in OG5_127061
Echinococcus granulosus DNA topoisomerase 2 alpha Get druggable targets OG5_127113 All targets in OG5_127113
Trypanosoma congolense DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Theileria parva DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein Get druggable targets OG5_128755 All targets in OG5_128755
Treponema pallidum DNA gyrase, subunit A (gyrA) Get druggable targets OG5_129568 All targets in OG5_129568
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans DNA topoisomerase II similar to S. cerevisiae TOP2 (YNL088W) Get druggable targets OG5_127113 All targets in OG5_127113
Leishmania braziliensis mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Toxoplasma gondii DNA topoisomerase 2, putative Get druggable targets OG5_127113 All targets in OG5_127113
Entamoeba histolytica DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Chlamydia trachomatis V-type ATP synthase subunit B Get druggable targets OG5_127061 All targets in OG5_127061
Brugia malayi Probable DNA topoisomerase II Get druggable targets OG5_127113 All targets in OG5_127113
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum hypothetical protein Get druggable targets OG5_127113 All targets in OG5_127113
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Echinococcus multilocularis vacuolar ATP synthase subunit b Get druggable targets OG5_127061 All targets in OG5_127061
Plasmodium falciparum DNA gyrase subunit B Get druggable targets OG5_128755 All targets in OG5_128755
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Trypanosoma cruzi DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Candida albicans DNA topoisomerase II similar to S. cerevisiae TOP2 (YNL088W) Get druggable targets OG5_127113 All targets in OG5_127113
Trypanosoma brucei gambiense DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) Get druggable targets OG5_129568 All targets in OG5_129568
Brugia malayi vacuolar ATP synthase subunit B Get druggable targets OG5_127061 All targets in OG5_127061
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Leishmania major DNA topoisomerase ii Get druggable targets OG5_127113 All targets in OG5_127113
Cryptosporidium parvum vacuolar ATP synthase subunit B Get druggable targets OG5_127061 All targets in OG5_127061
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) Get druggable targets OG5_129568 All targets in OG5_129568
Plasmodium yoelii DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni ATP synthase subunit beta vacuolar Get druggable targets OG5_127061 All targets in OG5_127061
Babesia bovis DNA gyrase A subunit, putative Get druggable targets OG5_129568 All targets in OG5_129568
Theileria parva DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Chlamydia trachomatis DNA gyrase subunit B Get druggable targets OG5_128755 All targets in OG5_128755
Entamoeba histolytica V-type ATPase, B subunit, putative Get druggable targets OG5_127061 All targets in OG5_127061
Leishmania infantum mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Treponema pallidum V-type ATP synthase subunit B Get druggable targets OG5_127061 All targets in OG5_127061
Trypanosoma brucei DNA topoisomerase II alpha, putative Get druggable targets OG5_127113 All targets in OG5_127113
Schistosoma japonicum ko:K02147 V-type H+-transporting ATPase subunit B, putative Get druggable targets OG5_127061 All targets in OG5_127061
Schistosoma japonicum ko:K03164 DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Giardia lamblia Vacuolar ATP synthase subunit B Get druggable targets OG5_127061 All targets in OG5_127061
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Treponema pallidum V-type ATP synthase subunit B Get druggable targets OG5_127061 All targets in OG5_127061
Cryptosporidium hominis DNA topoisomerase II Get druggable targets OG5_127113 All targets in OG5_127113
Trichomonas vaginalis DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Trypanosoma brucei Vacuolar proton pump subunit B, putative Get druggable targets OG5_127061 All targets in OG5_127061
Trichomonas vaginalis ATP synthase, putative Get druggable targets OG5_127061 All targets in OG5_127061
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) Get druggable targets OG5_128755 All targets in OG5_128755
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_127113 All targets in OG5_127113
Trypanosoma congolense DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Schistosoma japonicum Probable vacuolar ATP synthase subunit B, putative Get druggable targets OG5_127061 All targets in OG5_127061
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax vacuolar ATP synthase subunit b, putative Get druggable targets OG5_127061 All targets in OG5_127061
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Trypanosoma brucei DNA topoisomerase II beta, putative mitochondrial DNA topoisomerase II 1236 aa 1047 aa 35.1 %
Trypanosoma cruzi DNA topoisomerase II, putative DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 714 aa 649 aa 26.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi beta-NAC-like protein 0.0071 0.0102 0.0465
Echinococcus granulosus lysosomal alpha glucosidase 0.0332 0.0632 0.0632
Loa Loa (eye worm) hypothetical protein 0.0332 0.0632 0.2912
Onchocerca volvulus 0.0042 0.0043 0.0316
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0002 0.0005
Echinococcus multilocularis mitogen activated protein kinase 14 0.0119 0.0201 0.02
Plasmodium vivax DNA topoisomerase 3, putative 0.0031 0.0021 0.0147
Loa Loa (eye worm) hypothetical protein 0.0042 0.0043 0.0196
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.0014 0.0147
Loa Loa (eye worm) hypothetical protein 0.0153 0.0269 0.1236
Toxoplasma gondii ubiquinol-cytochrome c reductase 0.0076 0.0113 0.0843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.014 0.0139
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0025 0.0009 0.0008
Mycobacterium ulcerans DNA polymerase IV 0.004 0.004 0.0223
Schistosoma mansoni cpg binding protein 0.01 0.0161 0.016
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0014 0.0147
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0061
Echinococcus multilocularis mitogen activated protein kinase 11 0.0119 0.0201 0.02
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0014 0.0092
Brugia malayi Muscleblind-like protein 0.0153 0.0269 0.1236
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0432 0.0837 0.4442
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0041 0.0186
Schistosoma mansoni hypothetical protein 0.0126 0.0214 0.0214
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0035 0.0029 0.0028
Trypanosoma cruzi DNA topoisomerase III, putative 0.0031 0.0021 0.0108
Echinococcus multilocularis tumor protein p63 0.0346 0.0661 0.066
Trypanosoma brucei unspecified product 0.0028 0.0015 0.0069
Echinococcus multilocularis muscleblind protein 0.0153 0.0269 0.0268
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0114
Echinococcus granulosus mothers against decapentaplegic 2 0.0033 0.0025 0.0025
Echinococcus granulosus muscleblind protein 0.0153 0.0269 0.0268
Schistosoma mansoni hypothetical protein 0.0702 0.1384 0.1383
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0043 0.0196
Brugia malayi Smad1 0.0074 0.0109 0.0499
Loa Loa (eye worm) hypothetical protein 0.0022 0.0003 0.0011
Plasmodium falciparum DNA gyrase subunit B 0.0404 0.078 0.5883
Trypanosoma cruzi trypanothione reductase, putative 0.0134 0.023 0.1218
Plasmodium falciparum importin beta, putative 0.0029 0.0017 0.0118
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0046 0.0052 0.0269
Echinococcus granulosus mitogen activated protein kinase 14 0.0119 0.0201 0.02
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0034 0.0097
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.003 0.0133
Loa Loa (eye worm) hypothetical protein 0.0042 0.0043 0.0196
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0306 0.0581 0.058
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0043 0.0196
Loa Loa (eye worm) hypothetical protein 0.0042 0.0043 0.0196
Plasmodium falciparum pyruvate kinase 0.0035 0.003 0.021
Loa Loa (eye worm) hypothetical protein 0.0243 0.0453 0.2085
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0043 0.0042
Onchocerca volvulus Huntingtin homolog 0.0243 0.0453 0.4732
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0001
Loa Loa (eye worm) DNA topoisomerase III 0.0031 0.0021 0.0094
Trypanosoma cruzi ISWI complex protein 0.003 0.002 0.01
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0017 0.0083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0043 0.0196
Leishmania major carbonic anhydrase-like protein 0.0947 0.1882 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0096 0.0154 0.0707
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0086 0.0085
Echinococcus granulosus X box binding protein 1 0.0287 0.0541 0.054
Plasmodium falciparum glutathione reductase 0.0134 0.023 0.1726
Loa Loa (eye worm) TOPoisomerase family member 0.0306 0.0581 0.2675
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.004 0.0204
Loa Loa (eye worm) hypothetical protein 0.0089 0.014 0.0642
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0672 0.1324 0.1808
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.004 0.0039
Toxoplasma gondii aldehyde dehydrogenase 0.0189 0.0343 0.2582
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0006 0.0065
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0046 0.0052 0.0383
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0046 0.0052 0.0383
Trichomonas vaginalis maltase-glucoamylase, putative 0.0027 0.0014 0.0147
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0102 0.0102
Schistosoma mansoni transcription factor LCR-F1 0.022 0.0405 0.0404
Echinococcus multilocularis survival motor neuron protein 1 0.0948 0.1886 0.1885
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0417 0.0806 0.1086
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0046 0.0052 0.0383
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.014 0.0139
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.003 0.0148
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0034 0.0358
Mycobacterium ulcerans DNA gyrase subunit A 0.0672 0.1324 0.9116
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0084 0.0128 0.0127
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0126 0.0214 0.0985
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.003 0.0169
Loa Loa (eye worm) nuclear factor I 0.0041 0.0041 0.0188
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0043 0.0196
Giardia lamblia DINP protein human, muc B family 0.004 0.004 0.071
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0046 0.0052 0.0269
Schistosoma mansoni tar DNA-binding protein 0.0129 0.022 0.0219
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0043 0.0196
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0043 0.0042
Schistosoma mansoni tar DNA-binding protein 0.0129 0.022 0.0219
Toxoplasma gondii NADPH-glutathione reductase 0.0046 0.0052 0.0383
Trypanosoma brucei trypanothione reductase 0.0134 0.023 0.1214
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.052 0.1016 0.1015
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0008 0.0043
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.003 0.0314
Trypanosoma cruzi Vacuolar proton pump subunit B, putative 0.0054 0.0067 0.0351
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0043 0.0042
Mycobacterium tuberculosis Probable oxidoreductase 0.0339 0.0647 0.0865
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0031 0.0021 0.0108
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0008 0.0033
Schistosoma mansoni carbonic anhydrase 0.0735 0.1452 0.1451
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0043 0.0042
Brugia malayi hypothetical protein 0.022 0.0405 0.1865
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0305 0.0578 0.0769
Echinococcus multilocularis p2X purinoceptor 4 0.205 0.4125 0.4124
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0054 0.0435
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0052 0.0274
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0126 0.0214 0.0214
Mycobacterium ulcerans aldehyde dehydrogenase 0.0189 0.0343 0.2322
Echinococcus granulosus mothers against decapentaplegic 5 0.0074 0.0109 0.0108
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0014 0.0084
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0074 0.0108 0.1144
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0119 0.0201 0.106
Brugia malayi latrophilin 2 splice variant baaae 0.0272 0.0512 0.2357
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0027 0.0026
Leishmania major DNA topoisomerase 1A 0.0031 0.0021 0.0103
Schistosoma mansoni hypothetical protein 0.0311 0.059 0.0589
Brugia malayi CXXC zinc finger family protein 0.0091 0.0143 0.0655
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0046 0.0052 0.0269
Echinococcus granulosus p2X purinoceptor 4 0.205 0.4125 0.4124
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.004 0.0204
Plasmodium falciparum carbonic anhydrase 0.0445 0.0862 0.6506
Echinococcus granulosus kelch ECH associated protein 1 0.01 0.0161 0.016
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0306 0.0581 0.2675
Trichomonas vaginalis DNA topoisomerase II, putative 0.0306 0.0581 0.6166
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0054 0.0054
Schistosoma mansoni mucolipin 0.0058 0.0077 0.0076
Echinococcus granulosus mothers against decapentaplegic 6 0.0033 0.0025 0.0025
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0119 0.0201 0.0924
Loa Loa (eye worm) glutathione reductase 0.0134 0.023 0.1057
Plasmodium falciparum thioredoxin reductase 0.0134 0.023 0.1726
Leishmania major glycosyl hydrolase-like protein 0.0027 0.0014 0.0065
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0735 0.1452 0.6026
Echinococcus multilocularis dna polymerase kappa 0.004 0.004 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0015 0.0069
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0445 0.0862 0.3972
Loa Loa (eye worm) fli-1 protein 0.0438 0.0848 0.3908
Schistosoma mansoni hypothetical protein 0.0084 0.0128 0.0127
Trypanosoma cruzi ISWI complex protein 0.003 0.002 0.01
Loa Loa (eye worm) hypothetical protein 0.018 0.0324 0.1493
Mycobacterium ulcerans carbonic anhydrase 0.0735 0.1452 1
Brugia malayi Intermediate filament tail domain containing protein 0.0135 0.0233 0.1073
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0008 0.0038
Loa Loa (eye worm) hypothetical protein 0.0024 0.0008 0.0033
Loa Loa (eye worm) hypothetical protein 0.0153 0.0269 0.1236
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0046 0.0052 0.0269
Loa Loa (eye worm) vacuolar ATP synthase subunit B 0.0054 0.0067 0.0305
Brugia malayi mbt repeat family protein 0.0047 0.0054 0.0247
Trypanosoma brucei DNA topoisomerase III, putative 0.0031 0.0021 0.0103
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0074 0.0108 0.0802
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0002 0.0001
Chlamydia trachomatis DNA gyrase subunit A 0.0672 0.1324 1
Schistosoma mansoni smad1 5 8 and 0.0074 0.0109 0.0108
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0003 0.0011
Trypanosoma brucei unspecified product 0.004 0.004 0.0204
Schistosoma mansoni flap endonuclease-1 0.0025 0.0009 0.0008
Brugia malayi cytoplasmic intermediate filament protein 0.0073 0.0106 0.0484
Echinococcus granulosus lamin dm0 0.0135 0.0233 0.0233
Echinococcus granulosus mixed lineage leukemia protein mll 0.0025 0.0009 0.0008
Loa Loa (eye worm) CYP4Cod1 0.0024 0.0008 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0043 0.0196
Schistosoma mansoni apoptosis regulator bax 0.0084 0.0128 0.0127
Leishmania major DNA topoisomerase III, putative 0.0031 0.0021 0.0103
Loa Loa (eye worm) hypothetical protein 0.0076 0.0112 0.0514
Brugia malayi nuclear receptor NHR-88 0.0042 0.0043 0.0196
Trypanosoma brucei DNA topoisomerase III, putative 0.0031 0.0021 0.0103
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0043 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0318 0.0604 0.6415
Trypanosoma brucei DNA topoisomerase ii 0.0432 0.0837 0.444
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0114 0.0189 0.1288
Echinococcus granulosus GA binding protein alpha chain 0.0144 0.0251 0.0251
Echinococcus multilocularis pyruvate kinase 0.0035 0.003 0.0029
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0029 0.0203
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.0014 0.0069
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0123 0.0208 0.0208
Loa Loa (eye worm) Smad1 0.0074 0.0109 0.0499
Trypanosoma cruzi V-type proton ATPase subunit B, putative 0.0054 0.0067 0.0351
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0218 0.0402 0.0401
Echinococcus multilocularis snurportin 1 0.0311 0.059 0.0589
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.004 0.0426
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0046 0.0052 0.024
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0252 0.0469 0.491
Brugia malayi Glycosyl hydrolases family 31 protein 0.0027 0.0014 0.0061
Schistosoma mansoni importin beta-1 0.0029 0.0017 0.0017
Mycobacterium ulcerans aldehyde dehydrogenase 0.0189 0.0343 0.2322
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.052 0.1016 0.1015
Echinococcus multilocularis pyruvate kinase 0.0028 0.0014 0.0014
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0008 0.0032
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0031 0.0021 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0043 0.0196
Brugia malayi Cytochrome P450 family protein 0.0058 0.0077 0.035
Loa Loa (eye worm) hypothetical protein 0.0084 0.0128 0.0587
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.004 0.0182
Plasmodium vivax SET domain protein, putative 0.0063 0.0086 0.0635
Loa Loa (eye worm) carbonic anhydrase 3 0.0947 0.1882 0.8677
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0114 0.0189 0.0707
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.004 0.0039
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0014 0.0147
Echinococcus granulosus GPCR family 2 0.0126 0.0214 0.0214
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.003 0.0153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0043 0.0196
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0043 0.0042
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0043 0.0042
Brugia malayi Latrophilin receptor protein 2 0.0126 0.0214 0.0985
Plasmodium falciparum V-type proton ATPase subunit B 0.0054 0.0067 0.0493
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0065 0.0091 0.009
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0407 0.0785 0.5861
Brugia malayi MH2 domain containing protein 0.0074 0.0109 0.0499
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0332 0.0632 0.2913
Echinococcus granulosus p2X purinoceptor 4 0.205 0.4125 0.4124
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.004 0.0209
Echinococcus granulosus cpg binding protein 0.01 0.0161 0.016
Leishmania major trypanothione reductase 0.0134 0.023 0.1214
Loa Loa (eye worm) intermediate filament protein 0.0135 0.0233 0.1073
Plasmodium vivax DNA topoisomerase II, putative 0.0306 0.0581 0.4378
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0031 0.0021 0.0108
Onchocerca volvulus 0.0192 0.0348 0.3602
Trypanosoma brucei glycosyl hydrolase-like protein 0.0027 0.0014 0.0065
Trypanosoma cruzi ubiquinol-cytochrome c reductase complex 14kD subunit, putative 0.0076 0.0113 0.0597
Echinococcus granulosus kelch ECH associated protein 1 like 0.01 0.0161 0.016
Brugia malayi Bromodomain containing protein 0.0153 0.027 0.1241
Loa Loa (eye worm) hypothetical protein 0.0051 0.0061 0.0278
Brugia malayi hypothetical protein 0.0948 0.1886 0.8694
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0052 0.0274
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0034 0.0175
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0054 0.0054
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0014 0.0092
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.052 0.1016 0.1015
Schistosoma mansoni hypothetical protein 0.0126 0.0214 0.0214
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.004 0.0204
Loa Loa (eye worm) pyruvate kinase 0.0035 0.003 0.0133
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.003 0.0169
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0017 0.0083
Brugia malayi intermediate filament protein 0.0135 0.0233 0.1073
Trypanosoma cruzi transcription factor btf3, putative 0.0071 0.0102 0.0536
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0031 0.0021 0.002
Schistosoma mansoni transcription factor btf3 0.0071 0.0102 0.0101
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0126 0.0214 0.0214
Brugia malayi mbt repeat family protein 0.0047 0.0054 0.0247
Echinococcus multilocularis X box binding protein 1 0.0287 0.0541 0.054
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0034 0.0027 0.0123
Echinococcus granulosus mitogen activated protein kinase 11 0.0119 0.0201 0.02
Echinococcus multilocularis fetal alzheimer antigen, falz 0.005 0.0059 0.0059
Brugia malayi Coelomocyte uptake defective protein 5 0.0064 0.0088 0.0401
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0252 0.0469 0.491
Echinococcus granulosus zinc finger protein 0.0044 0.0047 0.0047
Onchocerca volvulus 0.0031 0.0021 0.0078
Echinococcus granulosus lamin 0.0135 0.0233 0.0233
Brugia malayi F/Y-rich N-terminus family protein 0.0034 0.0027 0.012
Brugia malayi RNA, U transporter 1 0.0083 0.0126 0.058
Mycobacterium leprae Conserved hypothetical protein 0.1199 0.2395 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0034 0.0179
Schistosoma mansoni coup transcription factor 0.0042 0.0043 0.0042
Chlamydia trachomatis replicative DNA helicase 0.0407 0.0785 0.5861
Brugia malayi Glycosyl hydrolases family 31 protein 0.0332 0.0632 0.2913
Loa Loa (eye worm) hypothetical protein 0.0063 0.0086 0.0393
Plasmodium falciparum flap endonuclease 1 0.0027 0.0014 0.0092
Loa Loa (eye worm) MBCTL1 0.0054 0.0068 0.0308
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0015 0.0069
Loa Loa (eye worm) mucolipin 1 0.0064 0.0088 0.0401
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0008 0.0033
Schistosoma mansoni aldehyde dehydrogenase 0.0189 0.0343 0.0342
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0029 0.0203
Leishmania major DNA topoisomerase III, putative 0.0031 0.0021 0.0103
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0129 0.022 0.1011
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0068 0.0067
Loa Loa (eye worm) inositol-1 0.0037 0.0034 0.0152
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0029 0.0147
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0046 0.0052 0.0238
Schistosoma mansoni zinc finger protein 0.0044 0.0047 0.0047
Echinococcus multilocularis Ubiquinol cytochrome c reductase complex 14 kDa 0.0332 0.0632 0.0631
Echinococcus multilocularis smad 0.0074 0.0109 0.0108
Echinococcus granulosus vacuolar ATP synthase subunit b 0.0054 0.0067 0.0066
Schistosoma mansoni smad1 5 8 and 0.0074 0.0109 0.0108
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0043 0.0196
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0065 0.0091 0.009
Entamoeba histolytica hypothetical protein 0.022 0.0405 0.2782
Loa Loa (eye worm) transcription factor SMAD2 0.1088 0.2169 1
Mycobacterium ulcerans DNA polymerase IV 0.004 0.004 0.0223
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0043 0.0316
Brugia malayi glutathione reductase 0.0134 0.023 0.1057
Schistosoma mansoni DNA topoisomerase II 0.0306 0.0581 0.058
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0133
Entamoeba histolytica DNA topoisomerase III, putative 0.0031 0.0021 0.0134
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0006 0.0028
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0021
Treponema pallidum replicative DNA helicase (dnaB) 0.0407 0.0785 0.5861
Echinococcus multilocularis carbonic anhydrase 0.0445 0.0862 0.0861
Loa Loa (eye worm) twinkle helicase 0.0116 0.0194 0.0893
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0027 0.0026
Echinococcus granulosus mucolipin 3 0.0064 0.0088 0.0087
Loa Loa (eye worm) hypothetical protein 0.0042 0.0043 0.0196
Entamoeba histolytica transcription factor BTF3, putative 0.0071 0.0102 0.0689
Brugia malayi RNA binding protein 0.0129 0.022 0.1011
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0119 0.0201 0.1064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0043 0.0196
Echinococcus multilocularis mitogen activated protein kinase 14 0.0119 0.0201 0.02
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0025 0.0009 0.0008
Echinococcus multilocularis mothers against decapentaplegic 5 0.0074 0.0109 0.0108
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0318 0.0604 0.0805
Loa Loa (eye worm) histone methyltransferase 0.003 0.002 0.0088
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0186 0.0337 0.0336
Entamoeba histolytica hypothetical protein 0.022 0.0405 0.2782
Schistosoma mansoni pyruvate kinase 0.0035 0.003 0.0029
Schistosoma mansoni Smad4 0.0033 0.0025 0.0025
Schistosoma mansoni Smad4 0.0074 0.0109 0.0108
Loa Loa (eye worm) hypothetical protein 0.018 0.0324 0.1493
Brugia malayi hypothetical protein 0.0022 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0022 0.0003 0.0011
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0074 0.0108 0.1144
Trypanosoma cruzi DNA repair protein, putative 0.0035 0.0029 0.0151
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.022 0.0405 0.0404
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0043 0.0196
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0043 0.0042
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0947 0.1882 0.8677
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0086 0.0085
Brugia malayi Inositol-1 0.0037 0.0034 0.0152
Trypanosoma brucei transcription factor BTF3, putative 0.0071 0.0102 0.0531
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0084 0.0128 0.0127
Leishmania major DNA topoisomerase ii 0.0275 0.0518 0.2744
Onchocerca volvulus 0.0484 0.0942 1
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.0029 0.0131
Schistosoma mansoni Ubiquinol-cytochrome c reductase complex 14 kDa protein 0.0332 0.0632 0.0631
Onchocerca volvulus Huntingtin homolog 0.0243 0.0453 0.4732
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0003 0.0002
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0305 0.0578 0.2346
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0275 0.0518 0.2744
Schistosoma mansoni tar DNA-binding protein 0.0129 0.022 0.0219
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0002 0.0005
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.003 0.0133
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0947 0.1882 0.1882
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0126 0.0214 0.0214
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0154 0.0153
Brugia malayi ecdysteroid receptor 0.0042 0.0043 0.0196
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0398 0.0768 0.3538
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.004 0.0209
Echinococcus multilocularis lysosomal alpha glucosidase 0.0332 0.0632 0.0632
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0947 0.1882 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0339 0.0647 0.2637
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0947 0.1882 0.1882
Brugia malayi Ets-domain containing protein 0.0144 0.0251 0.1156
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0407 0.0785 0.5381
Echinococcus multilocularis Kelch repeat type 1 0.01 0.0161 0.016
Schistosoma mansoni carbonic anhydrase-related 0.0445 0.0862 0.0861
Onchocerca volvulus 0.0091 0.0143 0.139
Schistosoma mansoni bromodomain containing protein 0.013 0.0223 0.0222
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.004 0.0204
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0043 0.0042
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0046 0.0052 0.0308
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0008 0.0033
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0947 0.1882 0.8677
Plasmodium vivax pyruvate kinase, putative 0.0035 0.003 0.021
Leishmania major alpha glucosidase II subunit, putative 0.0074 0.0108 0.0564
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0035 0.0029 0.0146
Brugia malayi TAR-binding protein 0.0129 0.022 0.1011
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0672 0.1324 1
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0034 0.0033
Brugia malayi Pre-SET motif family protein 0.0063 0.0086 0.0392
Echinococcus granulosus pyruvate kinase 0.0035 0.003 0.0029
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0043 0.0042
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3273 0.6611 0.917
Leishmania major hypothetical protein, conserved 0.0076 0.0113 0.0593
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0046 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0047 0.0054 0.0247
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0043 0.0196
Schistosoma mansoni smad1 5 8 and 0.0074 0.0109 0.0108
Loa Loa (eye worm) hypothetical protein 0.0022 0.0003 0.0011
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0061 0.006
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0432 0.0837 0.4442
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.004 0.0204
Echinococcus granulosus kelch ECH associated protein 1 like 0.01 0.0161 0.016
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0034 0.0027 0.0123
Onchocerca volvulus 0.0135 0.0233 0.2366
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0014 0.0013
Toxoplasma gondii NAC domain-containing protein 0.0071 0.0102 0.0756
Giardia lamblia Vacuolar ATP synthase subunit B 0.0054 0.0067 0.1204
Echinococcus multilocularis lamin 0.0135 0.0233 0.0233
Echinococcus granulosus tm gpcr rhodopsin 0.085 0.1686 0.1685
Trichomonas vaginalis conserved hypothetical protein 0.0318 0.0604 0.6415
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0084 0.0128 0.0127
Echinococcus granulosus carbonic anhydrase II 0.0947 0.1882 0.1882
Toxoplasma gondii vacuolar ATP synthase subunit b, putative 0.0054 0.0067 0.0493
Mycobacterium tuberculosis Probable reductase 0.0305 0.0578 0.0769
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0074 0.0109 0.0108
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.004 0.0204
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.004 0.0204
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0017 0.0118
Echinococcus multilocularis lamin dm0 0.0135 0.0233 0.0233
Schistosoma mansoni alpha-glucosidase 0.0285 0.0538 0.0538
Loa Loa (eye worm) pyruvate kinase 0.0035 0.003 0.0133
Echinococcus multilocularis mucolipin 3 0.0064 0.0088 0.0087
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0068 0.0067
Trypanosoma cruzi DNA topoisomerase II, putative 0.0275 0.0518 0.2747
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0311 0.059 0.2716
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0006 0.0065
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.003 0.0169
Onchocerca volvulus 0.0051 0.0061 0.0508
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.004 0.002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0043 0.0196
Giardia lamblia DNA topoisomerase II 0.0288 0.0543 1
Echinococcus granulosus smad 0.0074 0.0109 0.0108
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0003 0.0002
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0054 0.0054
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0046 0.0052 0.0052
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0306 0.0581 0.2675
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0008 0.0007
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0025 0.0009 0.0008
Leishmania major hypothetical protein, conserved 0.003 0.002 0.0095
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0144 0.0251 0.1156
Trypanosoma brucei ubiquinol-cytochrome c reductase complex 14 kda protein 0.0076 0.0113 0.0593
Leishmania major hypothetical protein, conserved 0.0035 0.0029 0.0143
Loa Loa (eye worm) hypothetical protein 0.0272 0.0512 0.2357
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0043 0.0042
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0043 0.0042
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0031 0.0021 0.002
Echinococcus granulosus dna polymerase eta 0.004 0.004 0.0039
Leishmania major DNA polymerase kappa, putative 0.004 0.004 0.0204
Schistosoma mansoni cpg binding protein 0.01 0.0161 0.016
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0054 0.0054
Trypanosoma brucei Vacuolar proton pump subunit B, putative 0.0054 0.0067 0.0347
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0672 0.1324 1
Brugia malayi PHD-finger family protein 0.0054 0.0069 0.0314
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0052 0.0274
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.0014 0.0069
Entamoeba histolytica V-type ATPase, B subunit, putative 0.0054 0.0067 0.045
Brugia malayi MH2 domain containing protein 0.1088 0.2169 1
Echinococcus granulosus Smad4 0.0074 0.0109 0.0108
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0046 0.0052 0.0269
Echinococcus granulosus intestinal type alkaline phosphatase 0.052 0.1016 0.1015
Brugia malayi Glycosyl hydrolases family 31 protein 0.0074 0.0108 0.0494
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0034 0.017
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0008 0.0007
Schistosoma mansoni P2X receptor subunit 0.205 0.4125 0.4124
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0034 0.017
Echinococcus multilocularis musashi 0.0135 0.0233 0.0233
Loa Loa (eye worm) pyruvate kinase 0.0035 0.003 0.0133
Echinococcus granulosus neutral alpha glucosidase AB 0.0074 0.0108 0.0107
Echinococcus multilocularis vacuolar ATP synthase subunit b 0.0054 0.0067 0.0066
Plasmodium falciparum DNA gyrase subunit A 0.0672 0.1324 1
Trypanosoma brucei pyruvate kinase 1 0.0035 0.003 0.0148
Loa Loa (eye worm) hypothetical protein 0.0042 0.0043 0.0196
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.014 0.0139
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0014 0.0147
Entamoeba histolytica hypothetical protein 0.0024 0.0006 0.0031
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0154 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.0043 0.0196
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0034 0.0033
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0303 0.0574 0.2329
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0046 0.0052 0.0308
Trichomonas vaginalis glutathione reductase, putative 0.0046 0.0052 0.0556
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.014 0.0641
Loa Loa (eye worm) thioredoxin reductase 0.0134 0.023 0.1057
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.004 0.0039
Trypanosoma cruzi ubiquinol-cytochrome c reductase complex 14kD subunit, putative 0.0076 0.0113 0.0597
Loa Loa (eye worm) hypothetical protein 0.014 0.0242 0.1113
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0086 0.0635
Brugia malayi MH2 domain containing protein 0.0033 0.0025 0.0114
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0182
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0015 0.0069
Schistosoma mansoni hypothetical protein 0.0193 0.0351 0.0351
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0043 0.0196
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0052 0.0274
Echinococcus granulosus alkaline phosphatase 0.052 0.1016 0.1015
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0054 0.0247
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.022 0.0405 0.0404
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0306 0.0581 0.058
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0029 0.0143
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0404 0.078 0.105
Schistosoma mansoni hypothetical protein 0.0126 0.0214 0.0214
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0034 0.0358
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0077 0.0076
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.014 0.0139
Echinococcus multilocularis kelch ECH associated protein 1 0.01 0.0161 0.016
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0445 0.0862 0.3972
Trichomonas vaginalis mercuric reductase, putative 0.0046 0.0052 0.0556
Echinococcus multilocularis neuropeptide s receptor 0.0468 0.0909 0.0909
Onchocerca volvulus 0.0047 0.0054 0.0435
Echinococcus multilocularis mitogen activated protein kinase 11 0.0119 0.0201 0.02
Loa Loa (eye worm) CXXC zinc finger family protein 0.0091 0.0143 0.0655
Schistosoma mansoni hypothetical protein 0.0084 0.0128 0.0127
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0068 0.0067
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0947 0.1882 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0046 0.0052 0.0269
Schistosoma mansoni inositol monophosphatase 0.0037 0.0034 0.0033
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0014 0.0069
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0404 0.078 0.5822
Schistosoma mansoni hypothetical protein 0.01 0.0161 0.016
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.0108 0.1144
Echinococcus multilocularis mothers against decapentaplegic 6 0.0033 0.0025 0.0025
Giardia lamblia DNA topoisomerase III 0.0031 0.0021 0.0358
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0119 0.0201 0.106
Schistosoma mansoni smad 0.0033 0.0025 0.0025
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0043 0.0042
Plasmodium vivax vacuolar ATP synthase subunit b, putative 0.0054 0.0067 0.0493
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0068 0.0067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0043 0.0196
Leishmania major importin beta-1 subunit, putative 0.0024 0.0006 0.0024
Toxoplasma gondii histone lysine methyltransferase SET1 0.0179 0.0322 0.2422
Schistosoma mansoni hypothetical protein 0.0272 0.0512 0.0511
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.085 0.1686 0.1685
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0008 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.014 0.0139
Brugia malayi nuclear hormone receptor 0.0042 0.0043 0.0196
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0046 0.0052 0.0308
Loa Loa (eye worm) hypothetical protein 0.0135 0.0233 0.1073
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0034 0.0175
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0046 0.0052 0.0274
Toxoplasma gondii thioredoxin reductase 0.0134 0.023 0.1726
Brugia malayi nuclear receptor RXR 0.0022 0.0003 0.0011
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0029 0.0203
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0034 0.0221
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.014 0.0139
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0029 0.0203
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0123 0.0208 0.0208
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0043 0.0042
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0027 0.0014 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.004 0.0204
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0445 0.0862 0.3972
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0135 0.0233 0.1073
Echinococcus multilocularis Smad4 0.0074 0.0109 0.0108
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0014 0.0061
Mycobacterium ulcerans recombinase A 0.0114 0.0189 0.1254
Brugia malayi Ets-domain containing protein 0.0144 0.0251 0.1156
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.004 0.0204
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.002 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.004 0.0209
Echinococcus granulosus fetal alzheimer antigen falz 0.005 0.0059 0.0059
Schistosoma mansoni zinc finger protein 0.003 0.002 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0043 0.0196
Schistosoma mansoni alpha glucosidase 0.0074 0.0108 0.0107
Brugia malayi Cytochrome P450 family protein 0.0024 0.0008 0.0033
Brugia malayi Pre-SET motif family protein 0.0425 0.0823 0.3791
Echinococcus granulosus intermediate filament protein 0.0135 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0022 0.0003 0.0011
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0043 0.0042
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0002 0.0005
Entamoeba histolytica DNA topoisomerase II, putative 0.0306 0.0581 0.3993
Trichomonas vaginalis set domain proteins, putative 0.0484 0.0942 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.0108 0.1144
Loa Loa (eye worm) hypothetical protein 0.0042 0.0043 0.0196
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0003 0.0011
Entamoeba histolytica carbonic anhydrase, putative 0.0735 0.1452 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0041 0.0188
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.003 0.021
Schistosoma mansoni hypothetical protein 0.0287 0.0541 0.054
Schistosoma mansoni hypothetical protein 0.1294 0.2587 0.2587
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.003 0.0035
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0002 0.0005
Trypanosoma cruzi transcription factor btf3, putative 0.0071 0.0102 0.0536
Echinococcus granulosus snurportin 1 0.0311 0.059 0.0589
Brugia malayi MH1 domain containing protein 0.0041 0.0041 0.0188
Schistosoma mansoni P2X receptor subunit 0.205 0.4125 0.4124
Echinococcus granulosus dnaJ subfamily B 0.1294 0.2587 0.2587
Plasmodium falciparum thioredoxin reductase 0.0046 0.0052 0.0383
Brugia malayi Stress-activated protein kinase jnk-1 0.0218 0.0402 0.185
Schistosoma mansoni cpg binding protein 0.0091 0.0143 0.0142
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0014 0.0147
Entamoeba histolytica hypothetical protein 0.0071 0.0102 0.0689
Plasmodium falciparum basic transcription factor 3b, putative 0.0071 0.0102 0.0756
Leishmania major DNA polymerase eta, putative 0.004 0.004 0.0204
Brugia malayi Augmenter of liver regeneration 0.0035 0.0029 0.0128
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0003 0.0002
Echinococcus multilocularis GPCR, family 2 0.0126 0.0214 0.0214
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0014 0.0065
Brugia malayi hypothetical protein 0.0243 0.0453 0.2085
Schistosoma mansoni tar DNA-binding protein 0.0129 0.022 0.0219
Echinococcus multilocularis pyruvate kinase 0.0035 0.003 0.0029
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.004 0.002
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0218 0.0402 0.185
Schistosoma mansoni mucolipin 0.0064 0.0088 0.0087
Brugia malayi MH2 domain containing protein 0.0074 0.0109 0.0499
Schistosoma mansoni Smad4 0.0033 0.0025 0.0025
Schistosoma mansoni P2X receptor subunit 0.205 0.4125 0.4124
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0052 0.0274
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0043 0.0196
Brugia malayi Importin beta-1 subunit 0.0029 0.0017 0.0077
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0084 0.0128 0.0127
Echinococcus multilocularis intestinal type alkaline phosphatase 0.052 0.1016 0.1015
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.0108 0.1144
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0027 0.0026
Echinococcus multilocularis rho GTPase activating protein 20 0.0031 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0021
Plasmodium vivax DNA gyrase subunit A, putative 0.0672 0.1324 1
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.004 0.0182
Chlamydia trachomatis DNA gyrase subunit B 0.0278 0.0524 0.3857
Treponema pallidum NADH oxidase 0.0046 0.0052 0.024
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0339 0.0647 0.0865
Leishmania major basic transcription factor 3a, putative 0.0071 0.0102 0.0531
Loa Loa (eye worm) hypothetical protein 0.0445 0.0862 0.3972
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0054 0.0054
Brugia malayi RNA recognition motif domain containing protein 0.0129 0.022 0.1011
Plasmodium falciparum DNA topoisomerase 3, putative 0.0031 0.0021 0.0147
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0008 0.0038
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0034 0.0358
Mycobacterium ulcerans DNA gyrase subunit B 0.0404 0.078 0.5345
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.004 0.0209
Schistosoma mansoni tar DNA-binding protein 0.0129 0.022 0.0219
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0073 0.0106 0.0484
Echinococcus granulosus pyruvate kinase 0.0035 0.003 0.0029
Echinococcus granulosus carbonic anhydrase 0.0445 0.0862 0.0861
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0043 0.0042
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0398 0.0768 0.3538
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0043 0.0196
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0425 0.0823 0.3791
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0189 0.0343 0.0342
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0043 0.0196
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0006 0.0065
Mycobacterium ulcerans aldehyde dehydrogenase 0.0189 0.0343 0.2322
Loa Loa (eye worm) hypothetical protein 0.0022 0.0003 0.0011
Echinococcus granulosus importin subunit beta 1 0.0029 0.0017 0.0017
Echinococcus multilocularis dnaJ subfamily B 0.1294 0.2587 0.2587
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0084 0.0128 0.0587
Loa Loa (eye worm) hypothetical protein 0.0445 0.0862 0.3972
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.014 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.004 0.0204
Echinococcus multilocularis alkaline phosphatase 0.052 0.1016 0.1015
Brugia malayi Bromodomain containing protein 0.0076 0.0112 0.0513
Echinococcus granulosus geminin 0.0702 0.1384 0.1383
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0077
Trypanosoma brucei ISWI complex protein 0.003 0.002 0.0095
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.004 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0043 0.0196
Echinococcus multilocularis microtubule associated protein 2 0.4941 1 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0068 0.0308
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0445 0.0862 0.3972
Schistosoma mansoni serine/threonine protein kinase 0.0218 0.0402 0.0401
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0046 0.0052 0.0052
Onchocerca volvulus 0.0063 0.0086 0.0773
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0084 0.0128 0.0127
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0074 0.0109 0.0108
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0043 0.0042
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0046 0.0052 0.024
Loa Loa (eye worm) ICD-1 protein 0.0071 0.0102 0.0465
Giardia lamblia Pyruvate kinase 0.0035 0.003 0.0514
Loa Loa (eye worm) MH2 domain-containing protein 0.0074 0.0109 0.0499
Echinococcus multilocularis neuropeptide receptor A26 0.0468 0.0909 0.0909
Loa Loa (eye worm) latrophilin receptor protein 2 0.0126 0.0214 0.0985
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0074 0.0108 0.0494
Loa Loa (eye worm) hypothetical protein 0.0398 0.0768 0.3538
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.004 0.0265
Loa Loa (eye worm) MH2 domain-containing protein 0.1088 0.2169 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.004 0.0039
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0046 0.0052 0.024
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0031 0.0021 0.002
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0031 0.0021 0.0147
Entamoeba histolytica hypothetical protein 0.022 0.0405 0.2782
Echinococcus multilocularis muscleblind protein 1 0.0153 0.0269 0.0268
Brugia malayi DNA topoisomerase III beta-1 0.0031 0.0021 0.0094
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0031 0.0021 0.0224
Trichomonas vaginalis maltase-glucoamylase, putative 0.0074 0.0108 0.1144
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0074 0.0108 0.0731
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.004 0.0204
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0034 0.0242
Plasmodium falciparum glutathione reductase 0.0046 0.0052 0.0383
Brugia malayi steroid hormone receptor 0.0042 0.0043 0.0196
Giardia lamblia DNA topoisomerase III 0.0031 0.0021 0.0358
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0123 0.0209 0.096
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0046 0.0052 0.0269
Leishmania major pyruvate kinase 0.0035 0.003 0.0148
Echinococcus granulosus flap endonuclease 1 0.0027 0.0014 0.0013
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.014 0.0641
Schistosoma mansoni pyruvate kinase 0.0035 0.003 0.0029
Giardia lamblia NADH oxidase lateral transfer candidate 0.0046 0.0052 0.0935
Leishmania major pyruvate kinase 0.0035 0.003 0.0148
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0014 0.0147
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0074 0.0108 0.0731
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0043 0.0196
Trypanosoma brucei DNA polymerase eta, putative 0.004 0.004 0.0204
Echinococcus multilocularis lysosomal alpha glucosidase 0.0332 0.0632 0.0632
Loa Loa (eye worm) apoptosis regulator protein 0.0084 0.0128 0.0587
Echinococcus granulosus neuropeptide receptor A26 0.0468 0.0909 0.0909
Echinococcus granulosus TGF beta signal transducer SmadC 0.0074 0.0109 0.0108
Schistosoma mansoni Replicative DNA helicase 0.0407 0.0785 0.0784
Loa Loa (eye worm) hypothetical protein 0.0042 0.0043 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0102 0.1079
Echinococcus multilocularis dna polymerase eta 0.004 0.004 0.0039
Plasmodium vivax DNA gyrase subunit B, putative 0.0404 0.078 0.5883
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0052 0.0274
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.003 0.0153
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0275 0.0517 0.39
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0077 0.035
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0947 0.1882 0.8677
Brugia malayi Thioredoxin reductase 0.0134 0.023 0.1057
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0186 0.0337 0.0336
Leishmania major cytochrome p450-like protein 0.0024 0.0008 0.0033
Trypanosoma cruzi DNA topoisomerase II, putative 0.0275 0.0518 0.2747
Schistosoma mansoni lamin 0.0135 0.0233 0.0233
Trypanosoma brucei glucosidase, putative 0.0074 0.0108 0.0564
Trypanosoma brucei carbonic anhydrase-like protein 0.0947 0.1882 1
Leishmania major vacuolar ATP synthase subunit b, putative 0.0054 0.0067 0.0347
Schistosoma mansoni ATP synthase subunit beta vacuolar 0.0054 0.0067 0.0066
Schistosoma mansoni microtubule-associated protein tau 0.4941 1 1
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0404 0.078 0.5822
Echinococcus granulosus c-Jun N-terminal kinases 0.0218 0.0402 0.0401
Chlamydia trachomatis DNA gyrase subunit A 0.0102 0.0166 0.1113
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0046 0.0052 0.0037
Echinococcus multilocularis GA binding protein alpha chain 0.0144 0.0251 0.0251
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0108 0.0568
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0043 0.0196
Loa Loa (eye worm) hypothetical protein 0.0118 0.0199 0.0912
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0027 0.0026
Schistosoma mansoni intermediate filament proteins 0.0135 0.0233 0.0233
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.003 0.0005
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0252 0.0469 0.491
Brugia malayi P38 map kinase family protein 2 0.0119 0.0201 0.0924
Loa Loa (eye worm) TAR-binding protein 0.0129 0.022 0.1011
Mycobacterium ulcerans pyruvate kinase 0.0035 0.003 0.015
Mycobacterium ulcerans carbonic anhydrase 0.0318 0.0604 0.4129
Onchocerca volvulus 0.0135 0.0233 0.2366
Trypanosoma cruzi DNA repair protein, putative 0.0035 0.0029 0.0151
Schistosoma mansoni hypothetical protein 0.0126 0.0214 0.0214
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0043 0.0316
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0031 0.0021 0.0224
Brugia malayi Cytochrome P450 family protein 0.0024 0.0008 0.0033
Schistosoma mansoni gabp alpha 0.0144 0.0251 0.0251
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0014 0.0225
Echinococcus granulosus histone lysine methyltransferase setb 0.0096 0.0154 0.0153
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0043 0.0316
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0407 0.0785 0.3217
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0025 0.0114
Brugia malayi Calcitonin receptor-like protein seb-1 0.0398 0.0768 0.3538
Trypanosoma brucei DNA topoisomerase IA, putative 0.0031 0.0021 0.0103
Treponema pallidum V-type ATP synthase subunit B 0.0054 0.0067 0.0352
Echinococcus granulosus transcription factor btf3 0.0071 0.0102 0.0101
Echinococcus multilocularis carbonic anhydrase II 0.0947 0.1882 0.1882
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0126 0.0214 0.0214
Schistosoma mansoni hypothetical protein 0.0041 0.0041 0.004
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0102 0.0102
Mycobacterium tuberculosis Probable dehydrogenase 0.0305 0.0578 0.0769
Brugia malayi MH1 domain containing protein 0.0041 0.0041 0.0188
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0029 0.0147
Schistosoma mansoni ets-related 0.0438 0.0848 0.0847
Echinococcus multilocularis mothers against decapentaplegic 2 0.0033 0.0025 0.0025
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0003 0.0002
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0026 0.002
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0043 0.0042
Echinococcus multilocularis transcription factor btf3 0.0071 0.0102 0.0101
Loa Loa (eye worm) hepatopoietin HPO2 0.0035 0.0029 0.0128
Chlamydia trachomatis pyruvate kinase 0.0035 0.003 0.0065
Echinococcus granulosus p2X purinoceptor 4 0.205 0.4125 0.4124
Loa Loa (eye worm) hypothetical protein 0.0243 0.0453 0.2085
Brugia malayi mothers against decapentaplegic homolog 3 0.0033 0.0025 0.0114
Trypanosoma cruzi DNA topoisomerase III, putative 0.0031 0.0021 0.0108
Entamoeba histolytica hypothetical protein 0.022 0.0405 0.2782
Toxoplasma gondii DNA topoisomerase family protein 0.0031 0.0021 0.0147
Schistosoma mansoni P2X receptor subunit 0.205 0.4125 0.4124
Echinococcus granulosus neuropeptide s receptor 0.0468 0.0909 0.0909
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0672 0.1324 1
Treponema pallidum V-type ATP synthase subunit B 0.0054 0.0067 0.0352
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0305 0.0578 0.0769
Echinococcus granulosus survival motor neuron protein 1 0.0948 0.1886 0.1885
Brugia malayi vacuolar ATP synthase subunit B 0.0054 0.0067 0.0305
Schistosoma mansoni hypothetical protein 0.0445 0.0862 0.0861
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.003 0.0314
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0305 0.0578 0.0769
Echinococcus multilocularis p2X purinoceptor 4 0.205 0.4125 0.4124
Loa Loa (eye worm) hypothetical protein 0.0065 0.0091 0.0416
Entamoeba histolytica DNA topoisomerase III, putative 0.0031 0.0021 0.0134
Echinococcus granulosus dna polymerase kappa 0.004 0.004 0.0039
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0002 0.0001
Schistosoma mansoni hypothetical protein 0.003 0.002 0.0019
Trichomonas vaginalis sucrase-isomaltase, putative 0.0074 0.0108 0.1144
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0043 0.0042
Echinococcus granulosus carbonic anhydrase 0.0445 0.0862 0.0861
Chlamydia trachomatis V-type ATP synthase subunit B 0.0054 0.0067 0.0352
Schistosoma mansoni hypothetical protein 0.0287 0.0542 0.0542
Trichomonas vaginalis ATP synthase, putative 0.0054 0.0067 0.0711
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0025 0.0114
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.3566 0.7207 1
Schistosoma mansoni alpha-glucosidase 0.0285 0.0538 0.0538
Trichomonas vaginalis ATP synthase alpha subunit mitochondrial, putative 0.0054 0.0067 0.0711
Echinococcus multilocularis cpg binding protein 0.01 0.0161 0.016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0052 0.0274
Loa Loa (eye worm) RNA binding protein 0.0129 0.022 0.1011
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0275 0.0518 0.2744
Echinococcus multilocularis neutral alpha glucosidase AB 0.0074 0.0108 0.0107
Schistosoma mansoni inositol monophosphatase 0.0037 0.0034 0.0033
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0339 0.0647 0.0865
Brugia malayi Flap endonuclease-1 0.0027 0.0014 0.0061
Trichomonas vaginalis ran, putative 0.0021 0.0002 0.0018
Schistosoma mansoni carbonic anhydrase-related 0.0445 0.0862 0.0861
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.052 0.1016 0.1015
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0445 0.0862 0.3972
Echinococcus multilocularis thioredoxin glutathione reductase 0.0134 0.0231 0.023
Plasmodium vivax importin-beta 2, putative 0.0029 0.0017 0.0118
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0014 0.0147
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0046 0.0052 0.0383
Loa Loa (eye worm) MH1 domain-containing protein 0.0074 0.0109 0.0499
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0189 0.0343 0.1816
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0025 0.0009 0.0008
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0043 0.0042
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0054 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0043 0.0196
Schistosoma mansoni lamin 0.0135 0.0233 0.0233
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0102 0.1079
Brugia malayi DNA topoisomerase III 0.0031 0.0021 0.0094
Schistosoma mansoni hypothetical protein 0.0084 0.0128 0.0127
Treponema pallidum recombinase A 0.0114 0.0189 0.1288
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0043 0.0042
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0043 0.0042
Echinococcus granulosus tumor protein p63 0.0346 0.0661 0.066
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0108 0.0568
Loa Loa (eye worm) hypothetical protein 0.0118 0.0199 0.0912
Brugia malayi MH1 domain containing protein 0.0074 0.0109 0.0499
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.0108 0.1144
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0033 0.0025 0.0125
Schistosoma mansoni aldehyde dehydrogenase 0.0189 0.0343 0.0342
Echinococcus multilocularis carbonic anhydrase 0.0445 0.0862 0.0861
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0119 0.0201 0.1064
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0149 0.0261 0.1012
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0043 0.0042
Echinococcus multilocularis carbonic anhydrase 0.0445 0.0862 0.0861
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0035 0.0029 0.0028
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0134 0.023 0.0284
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0014 0.0065
Brugia malayi hypothetical protein 0.0022 0.0003 0.0011
Schistosoma mansoni DNA polymerase eta 0.004 0.004 0.0039
Echinococcus granulosus thioredoxin glutathione reductase 0.0134 0.0231 0.023
Brugia malayi Fli-1 protein 0.0438 0.0848 0.3908
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0008 0.0033
Schistosoma mansoni alkaline phosphatase 0.052 0.1016 0.1015
Trypanosoma cruzi DNA topoisomerase III, putative 0.0031 0.0021 0.0108
Plasmodium vivax ubiquinol-cytochrome c reductase complex subunit, putative 0.0076 0.0113 0.0843
Leishmania major carbonic anhydrase family protein, putative 0.0735 0.1452 0.7711
Plasmodium falciparum DNA topoisomerase 2 0.0306 0.0581 0.4378
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0445 0.0862 0.3972
Schistosoma mansoni hypothetical protein 0.022 0.0405 0.0404
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0043 0.0042
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0008 0.0046
Loa Loa (eye worm) hypothetical protein 0.0126 0.0214 0.0985
Echinococcus granulosus carbonic anhydrase 0.0445 0.0862 0.0861
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0068 0.0308
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0029 0.0147
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0189 0.0343 0.0442
Brugia malayi MH1 domain containing protein 0.0074 0.0109 0.0499
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0054 0.0054
Echinococcus granulosus tar DNA binding protein 0.0129 0.022 0.0219
Schistosoma mansoni alkaline phosphatase 0.052 0.1016 0.1015
Chlamydia trachomatis recombinase RecA 0.0114 0.0189 0.1288
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.005 0.0059 0.0059
Trypanosoma brucei cytochrome P450, putative 0.0024 0.0008 0.0033
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.004 0.0182
Plasmodium falciparum cytochrome b-c1 complex subunit 7, putative 0.0076 0.0113 0.0843
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0046 0.0052 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0008 0.0082
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0445 0.0862 0.3972
Trypanosoma brucei unspecified product 0.0028 0.0015 0.0069
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0193 0.0351 0.1617
Plasmodium vivax basic transcription factor 3b, putative 0.0071 0.0102 0.0756
Loa Loa (eye worm) hypothetical protein 0.0133 0.0228 0.105
Schistosoma mansoni carbonic anhydrase-related 0.0445 0.0862 0.0861
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.0108 0.1144
Schistosoma mansoni ran 0.0021 0.0002 0.0001
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0068 0.0067
Loa Loa (eye worm) hypothetical protein 0.008 0.0122 0.0558
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1615 0.324 0.324
Loa Loa (eye worm) hypothetical protein 0.0063 0.0086 0.0393
Leishmania major mitochondrial DNA topoisomerase II 0.0432 0.0837 0.444
Echinococcus granulosus Ubiquinol cytochrome c reductase complex 14 kDa 0.0332 0.0632 0.0631
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0043 0.0042
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0043 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.004 0.0204
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0195 0.0354 0.0354
Toxoplasma gondii DNA topoisomerase 2, putative 0.0306 0.0581 0.4378
Echinococcus multilocularis geminin 0.0702 0.1384 0.1383
Echinococcus multilocularis tar DNA binding protein 0.0129 0.022 0.0219
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0305 0.0578 0.0769
Plasmodium vivax glutathione reductase, putative 0.0134 0.023 0.1726
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0043 0.0042
Brugia malayi GRF zinc finger family protein 0.0031 0.0021 0.0094
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0043 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0102 0.1079
Echinococcus multilocularis p2X purinoceptor 4 0.205 0.4125 0.4124
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0031 0.0021 0.002
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0043 0.0042
Schistosoma mansoni smad 0.0074 0.0109 0.0108
Schistosoma mansoni survival motor neuron protein 0.0193 0.0351 0.0351
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0046 0.0052 0.0383
Schistosoma mansoni hypothetical protein 0.027 0.0508 0.0507
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0046 0.0052 0.0274
Schistosoma mansoni carbonic anhydrase 0.0445 0.0862 0.0861
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0043 0.0042
Toxoplasma gondii hypothetical protein 0.0445 0.0862 0.6506
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.0014 0.0147
Echinococcus multilocularis kelch ECH associated protein 1 0.01 0.0161 0.016
Brugia malayi Probable DNA topoisomerase II 0.0306 0.0581 0.2675
Entamoeba histolytica hypothetical protein 0.0024 0.0008 0.0042
Echinococcus multilocularis zinc finger protein 0.0044 0.0047 0.0047
Schistosoma mansoni ran 0.0021 0.0002 0.0001
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0043 0.0196
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0189 0.0343 0.0342
Chlamydia trachomatis DNA gyrase subunit B 0.0404 0.078 0.5822
Schistosoma mansoni hypothetical protein 0.0702 0.1384 0.1383
Mycobacterium ulcerans DNA topoisomerase I 0.0031 0.0021 0.0091
Plasmodium vivax thioredoxin reductase, putative 0.0134 0.023 0.1726
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0086 0.0085
Onchocerca volvulus 0.0193 0.0351 0.3638
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0096 0.0154 0.0153
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.004 0.0204
Loa Loa (eye worm) hypothetical protein 0.0948 0.1886 0.8694
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.004 0.0209
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0008 0.0037
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.004 0.0426
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0031 0.0021 0.002

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 1.068 uM PUBCHEM_BIOASSAY: Bacterial Growth Inhibition Counterscreen using BacTiter-Glo Measured in Microorganism System Using Plate Reader - 2093-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488938] ChEMBL. No reference
Activity (binding) Inhibition of maltose binding protein-fused human V-ATPase subunit B2 binding to F-actin ChEMBL. 19630402
CMI (functional) = 0.16 mg l-1 Activity of the compound against Enterobacter aerogenes ChEMBL. 12873497
ED50 (functional) = 0.6 mg kg-1 In vivio inhibitory activity of the compound against E. coli Juhl after subcutaneous administration in mice ChEMBL. 3934382
ED50 (functional) = 1.8 mg kg-1 Compound was evaluated in vivo for oral antibacterial activity against Escherichia coli P-5101 at a dose of 9E6 ChEMBL. 6438319
ED50 (functional) = 1.8 mg kg-1 Median effective dose against E. coli P-5101 causing systemic infections ChEMBL. 6422043
ED50 (functional) = 1.8 mg kg-1 Compound was evaluated in vivo for oral antibacterial activity against Escherichia coli P-5101 at a dose of 9E6 ChEMBL. 6438319
ED50 (functional) = 1.8 mg kg-1 Median effective dose against E. coli P-5101 causing systemic infections ChEMBL. 6422043
ED50 (functional) = 1.9 mg kg-1 Antibacterial activity against E. coli P-5101 microbial strains in mice was determined expressed as ED50 (mg/kg) ChEMBL. 3114492
ED50 (functional) = 1.9 mg kg-1 Antibacterial activity against E. coli P-5101 microbial strains in mice was determined expressed as ED50 (mg/kg) ChEMBL. 3114492
ED50 (functional) = 9 mg kg-1 Compound was evaluated in vivo for oral antibacterial activity against P. aeruginosa 12 at a dose of 4E3 ChEMBL. 6438319
ED50 (functional) = 9 mg kg-1 Antibacterial activity against P. aeruginosa 12 microbial strains in mice was determined expressed as ED50 (mg/kg) ChEMBL. 3114492
ED50 (functional) = 9 mg kg-1 Median effective dose against P. aeruginosa 12 causing systemic infections ChEMBL. 6422043
ED50 (functional) = 9 mg kg-1 Antibacterial activity against P. aeruginosa 12 microbial strains in mice was determined expressed as ED50 (mg/kg) ChEMBL. 3114492
ED50 (functional) = 10 mg kg-1 Compound was evaluated in vivo for oral antibacterial activity against Staphylococcus aureus 50774 at a dose of 5E8 ChEMBL. 6438319
ED50 (functional) = 10 mg kg-1 Antibacterial activity (oral efficacy) against systemic infections due to S. aureus 50774 microbial strains in mice was determined ChEMBL. 3114492
ED50 (functional) = 10 mg kg-1 Median effective dose against S. aureus 50774 causing systemic infections ChEMBL. 6422043
ED50 (functional) = 10 mg kg-1 Antibacterial activity (oral efficacy) against systemic infections due to S. aureus 50774 microbial strains in mice was determined ChEMBL. 3114492
ED50 (functional) = 15.1 mg kg-1 In vivo inhibitory activity of the compound against E. coli Juhl after peroral administration in mice ChEMBL. 3934382
F (ADMET) = 87.38 % Bioavailability ChEMBL. 12873497
F (ADMET) = 89 % Oral bioavailability in human ChEMBL. 19947605
GI50 (functional) -4.507 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.484 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.163 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
I50 (binding) = 28 ug ml-1 Inhibitory concentration in supercoiling inhibition E. coli DNA gyrase assay ChEMBL. 3005575
IC50 (binding) DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Calcitonin radioligand binding (ligand: [125I] Calcitonin (salmon)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protease, Cathepsin G enzyme inhibition (substrate: Suc-Ala-Ala-Pro-Phe-AMC) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Bradykinin B2 radioligand binding (ligand: [3H] Bradykinin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CXCR2 (IL-8B) radioligand binding (ligand: [125I] IL-8) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Insulin radioligand binding (ligand: [125I] Insulin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2E1 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Neuropeptide Y Y1 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Nitric Oxide Synthase, Inducible (iNOS) enzyme inhibition (substrate: L-Arginine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Vascular Endothelial Growth Factor (VEGF) radioligand binding (ligand: [125I] VEGF) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CCR2B radioligand binding (ligand: [125I] MCP-1) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cannabinoid CB1 radioligand binding (ligand: [3H] SR141716A) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Phosphatase, PPP3CA (Calcineurin, PP2B) enzyme inhibition (substrate: DiFMUP) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2A6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cysteinyl leukotriene receptor 1 radioligand binding (ligand: [3H]LTD4) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cholecystokinin CCKA radioligand binding (ligand: [3H] L-364,718) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protease, Caspase 1 enzyme inhibition (substrate: Ac-YVAD-AMC) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CCR5 radioligand binding (ligand: [125I] MIP-1alpha) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Leukotriene LTC4 Synthase enzyme inhibition (substrate: LTA4) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, ERBB2 (HER2) enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Estrogen ERbeta radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Neuropeptide Y Y2 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Peptidase, ELA2 (Neutrophil Elastase 2) enzyme inhibition (substrate: N-MeOSuc-Ala-Ala-Pro-Val-pNA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Vasoactive Intestinal Peptide VIP1 radioligand binding (ligand: [125I] VIP) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CXCR1 (IL-8A) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Nitric Oxide Synthase, Neuronal (nNOS) radioligand binding (ligand: [3H]L-Arginine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Peptidase, Matrix Metalloprotease-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase PKCalpha enzyme inhibition (substrate: Histone) ChEMBL. No reference
IC50 (binding) = 28 ug ml-1 Inhibitory concentration in supercoiling inhibition E. coli DNA gyrase assay ChEMBL. 3005575
IC50 (binding) = 10 uM Inhibition of maltose binding protein-fused human V-ATPase subunit B2 binding to F-actin ChEMBL. 19630402
IC50 (binding) = 14 uM Inhibition of Escherichia coli DNA gyrase GyrA/GyrB ChEMBL. 18426901
IC50 (functional) = 20 uM Antimalarial activity against blood stage form of Plasmodium falciparum assessed as incorporation of [3H]hypoxanthine after 72 hrs by liquid scintillation counting ChEMBL. 24650715
IC50 (functional) = 36 uM Inhibition of human NCI-H460 cell proliferation by sulphorodhamine B assay ChEMBL. 19595598
IC50 (functional) = 76.8 uM DNDI: Malaria in Vitro, 72 hour ChEMBL. No reference
IC50 (functional) > 93.66 uM DNDI: Leish (macro) in Vitro, 96 hour ChEMBL. No reference
IC50 (functional) = 113.01 uM DNDI: HAT in Vitro, 72 hour ChEMBL. No reference
IC50 (functional) = 137 uM Inhibition of human KB cell proliferation by MTT assay ChEMBL. 19595598
IC50 (functional) = 150 uM Inhibition of human A431 cell proliferation by MTT assay ChEMBL. 19595598
IC50 (functional) = 159 uM Inhibition of human SW480 cell proliferation by MTT assay ChEMBL. 19595598
IC50 (functional) = 162.65 uM DNDI: Chagas in Vitro, 96 hour ChEMBL. No reference
IC50 (functional) = 170 uM Inhibition of human HeLa cell proliferation ChEMBL. 19595598
IC50 (functional) = 178 uM Inhibition of human EJ cell proliferation by MTT assay ChEMBL. 19595598
IC50 (functional) = 193 uM Inhibition of human MCF7 cell proliferation by MTT assay ChEMBL. 19595598
IC50 (functional) = 196 uM Inhibition of human SK-MEL cell proliferation by MTT assay ChEMBL. 19595598
IC50 (functional) > 312.18 uM DNDI: Leish (axenic) in Vitro, 72 hour ChEMBL. No reference
Inhibition (binding) Inhibition of Saccharomyces cerevisiae V-ATPase subunit B expressed in Escherichia coli binding to rabbit muscle actin filament at 100 uM by pelleting assay ChEMBL. 19630402
Inhibition (ADMET) = 89.57706794 % Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Inhibition (ADMET) = 111.1096927 % Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Ki (binding) DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protease, Cathepsin G enzyme inhibition (substrate: Suc-Ala-Ala-Pro-Phe-AMC) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CCR2B radioligand binding (ligand: [125I] MCP-1) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Insulin radioligand binding (ligand: [125I] Insulin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Vasoactive Intestinal Peptide VIP1 radioligand binding (ligand: [125I] VIP) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Calcitonin radioligand binding (ligand: [125I] Calcitonin (salmon)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CCR5 radioligand binding (ligand: [125I] MIP-1alpha) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Neuropeptide Y Y1 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Vascular Endothelial Growth Factor (VEGF) radioligand binding (ligand: [125I] VEGF) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protease, Caspase 1 enzyme inhibition (substrate: Ac-YVAD-AMC) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Bradykinin B2 radioligand binding (ligand: [3H] Bradykinin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2E1 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cysteinyl leukotriene receptor 1 radioligand binding (ligand: [3H]LTD4) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Leukotriene LTC4 Synthase enzyme inhibition (substrate: LTA4) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase PKCalpha enzyme inhibition (substrate: Histone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Phosphatase, PPP3CA (Calcineurin, PP2B) enzyme inhibition (substrate: DiFMUP) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2A6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CXCR2 (IL-8B) radioligand binding (ligand: [125I] IL-8) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Peptidase, ELA2 (Neutrophil Elastase 2) enzyme inhibition (substrate: N-MeOSuc-Ala-Ala-Pro-Val-pNA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CXCR1 (IL-8A) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Tyrosine Kinase, ERBB2 (HER2) enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Estrogen ERbeta radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Neuropeptide Y Y2 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Nitric Oxide Synthase, Neuronal (nNOS) radioligand binding (ligand: [3H]L-Arginine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Nitric Oxide Synthase, Inducible (iNOS) enzyme inhibition (substrate: L-Arginine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cholecystokinin CCKA radioligand binding (ligand: [3H] L-364,718) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cannabinoid CB1 radioligand binding (ligand: [3H] SR141716A) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Peptidase, Matrix Metalloprotease-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine) ChEMBL. No reference
LD50 (ADMET) > 2000 mg kg-1 Compound was tested for acute toxicity test with a single oral administration in mice and the median lethal dose as calculated. ChEMBL. 6422043
LD50 (ADMET) > 2000 mg kg-1 Compound was tested for acute toxicity test with a single oral administration in mice and the median lethal dose as calculated. ChEMBL. 6422043
MIC (functional) < 0.015 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium S21 acrAB::Kan ChEMBL. 17043131
MIC (functional) < 0.015 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium S21 tolC::Kan ChEMBL. 17043131
MIC (functional) < 0.015 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS14 tolC::Kan with GyrA D87G mutant ChEMBL. 17043131
MIC (functional) < 0.015 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS38 gyrA+ with GyrA D87G mutation ChEMBL. 17043131
MIC (functional) < 0.015 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS38 tolC::Kan with GyrA D87G mutation ChEMBL. 17043131
MIC (functional) = 0.03 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS14 gyrA+ with GyrA D87G mutation ChEMBL. 17043131
MIC (functional) = 0.03 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS18 tolC::Kan with GyrA S38F mutation ChEMBL. 17043131
MIC (functional) = 0.03 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS38 acrAB::Kan with GyrA D87G mutation ChEMBL. 17043131
MIC (functional) < 0.03 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS14 acrAB::Kan with GyrA D87G mutation ChEMBL. 17043131
MIC (functional) = 0.031 ug ml-1 Antimicrobial activity against AcrAB-deficient Escherichia coli AG100AX harboring pBAD plasmid after 18 to 24 hrs by two fold dilution method ChEMBL. 18591276
MIC (functional) = 0.06 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium S21 ChEMBL. 17043131
MIC (functional) = 0.06 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium S21 gyrA+ ChEMBL. 17043131
MIC (functional) = 0.06 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-1 gyrA+ ChEMBL. 17043131
MIC (functional) = 0.06 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium GyrA S21-1 acrAB::Kan with GyrA S83F mutation ChEMBL. 17043131
MIC (functional) = 0.06 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-1 tolC::Kan with GyrA S83F mutation ChEMBL. 17043131
MIC (functional) = 0.06 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium CS1 gyrA+ with GyrA S83F, D87N, ParC S80I mutation ChEMBL. 17043131
MIC (functional) = 0.06 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium CS3 gyrA+ with GyrA S83F, D87N, ParC S80I mutation ChEMBL. 17043131
MIC (functional) = 0.06 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium CS9 gyrA+ with GyrA S83F, D87N, ParC S80I mutation ChEMBL. 17043131
MIC (functional) = 0.063 ug ml-1 Antimicrobial activity against AcrAB-deficient Escherichia coli AG100AX harboring pBADomeganorM plasmid containing Neisseria gonorrhoeae multidrug efflux pump NorM after 18 to 24 hrs by two fold dilution method ChEMBL. 18591276
MIC (functional) = 0.063 ug ml-1 Antimicrobial activity against AcrAB-deficient Escherichia coli AG100AX harboring pBADomegaydhE plasmid containing Escherichia coli multidrug efflux pump YdhE after 18 to 24 hrs by two fold dilution method ChEMBL. 18591276
MIC (functional) = 0.098 ug ml-1 Antibacterial activity against Klebsiella pneumoniae ATCC 10031 by agar-dilution method ChEMBL. 16644219
MIC (functional) = 0.098 ug ml-1 Antibacterial activity against Escherichia coli ATCC 8739 by agar-dilution method ChEMBL. 16644219
MIC (functional) = 0.098 ug ml-1 Antibacterial activity against Bacillus subtilis ATCC 6633 by agar-dilution method ChEMBL. 16644219
MIC (functional) = 0.098 ug ml-1 Antibacterial activity against Escherichia coli ATCC 8739 by agar-dilution method ChEMBL. 16644219
MIC (functional) = 0.1 ug ml-1 Compound was tested for inhibition of the gram-negative organism Escherichia coli H560 ChEMBL. 3007757
MIC (functional) = 0.1 ug ml-1 Compound was tested for inhibition of the gram-negative organism P. rettgeri H1771 ChEMBL. 3007757
MIC (functional) = 0.1 ug ml-1 In vitro antibacterial activity against klebsiella pneumoniae B54,Kp,(gram-negative) ChEMBL. 1310116
MIC (functional) = 0.1 ug ml-1 Activity against K. pneumoniae (PCI-602) ChEMBL. 2163456
MIC (functional) = 0.1 ug ml-1 Minimum inhibition concentration in vitro determined against Escherichia coli juhl ChEMBL. 3934382
MIC (functional) = 0.1 ug ml-1 Minimum inhibition concentration in vitro determined against Klebsiella pneumoniae 8045 ChEMBL. 3934382
MIC (functional) = 0.1 ug ml-1 Antibacterial activity against E. coli P-5101 microbial strains in mice was determined expressed as MIC ChEMBL. 3114492
MIC (functional) = 0.1 ug ml-1 Antibacterial activity of the compound against Escherichia coli (H560) ChEMBL. 3005575
MIC (functional) = 0.1 ug ml-1 Antibacterial activity of the compound against Escherichia coli (vogel) ChEMBL. 3005575
MIC (functional) = 0.1 ug ml-1 Antibacterial activity of the compound against Klebsiella pneumonia (MGH-2) ChEMBL. 3005575
MIC (functional) = 0.1 ug ml-1 Antibacterial activity of the compound against Escherichia coli (H560) ChEMBL. 3005575
MIC (functional) = 0.1 ug ml-1 Antibacterial activity of the compound against Escherichia coli (vogel) ChEMBL. 3005575
MIC (functional) = 0.1 ug ml-1 Antibacterial activity of the compound against Klebsiella pneumonia (MGH-2) ChEMBL. 3005575
MIC (functional) = 0.1 ug ml-1 Compound was tested for inhibition of the gram-negative organism Escherichia coli H560 ChEMBL. 3007757
MIC (functional) = 0.1 ug ml-1 Antibacterial activity against E. coli P-5101 microbial strains in mice was determined expressed as MIC ChEMBL. 3114492
MIC (functional) = 0.12 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-2 acrAB::Kan with GyrA S83F, ParC S80I mutation ChEMBL. 17043131
MIC (functional) = 0.12 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-2 tolC::Kan with GyrA S83F, ParC S80I mutation ChEMBL. 17043131
MIC (functional) = 0.12 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-3 tolC::Kan with GyrA S83F, ParC S80I mutation ChEMBL. 17043131
MIC (functional) = 0.12 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-4 acrAB::Kan with GyrA S83F, ParC S80I mutation ChEMBL. 17043131
MIC (functional) = 0.12 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-4 tolC::Kan with GyrA S83F, ParC S80I mutation ChEMBL. 17043131
MIC (functional) = 0.12 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS18 gyrA+ with GyrA S38F mutation ChEMBL. 17043131
MIC (functional) = 0.12 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS38 with GyrA D87G mutation ChEMBL. 17043131
MIC (functional) = 0.13 ug ml-1 In vitro antibacterial activity against E. coli (A 15119) ChEMBL. 2918499
MIC (functional) = 0.13 ug ml-1 In vitro antibacterial activity against M. morganii (A 15153) ChEMBL. 2918499
MIC (functional) = 0.13 ug ml-1 In vitro antibacterial activity against E. coli (A 15119) ChEMBL. 2918499
MIC (functional) = 0.2 ug ml-1 In vitro antibacterial activity against Escherichia coli NIHJ JC-2 ChEMBL. 6438319
MIC (functional) = 0.2 ug ml-1 Compound was tested for inhibition of the gram-negative organism Escherichia cloacae HA 2646 ChEMBL. 3007757
MIC (functional) = 0.2 ug ml-1 Compound was tested for inhibition of the gram-negative organism Escherichia coli vogel ChEMBL. 3007757
MIC (functional) = 0.2 ug ml-1 Compound was tested for inhibition of the gram-negative organism K. pneumoniae MGH-2 ChEMBL. 3007757
MIC (functional) = 0.2 ug ml-1 In vitro antibacterial activity against E. coli NIHJ JC-2,(gram-negative) ChEMBL. 1310116
MIC (functional) = 0.2 ug ml-1 In vitro antibacterial activity against E. coli KC-14,Ec(K),(gram-negative) ChEMBL. 1310116
MIC (functional) = 0.2 ug ml-1 Activity against B. subtilis (ATCC 6633) ChEMBL. 2163456
MIC (functional) = 0.2 ug ml-1 Activity against E. coli (K-12 C600) ChEMBL. 2163456
MIC (functional) = 0.2 ug ml-1 Activity against E. coli (KC-14) ChEMBL. 2163456
MIC (functional) = 0.2 ug ml-1 Activity against E. aerogenes (ATCC 13048) ChEMBL. 2163456
MIC (functional) = 0.2 ug ml-1 Minimum inhibition concentration in vitro determined against Enterobacteri aerogenes ATCC 13048 ChEMBL. 3934382
MIC (functional) = 0.2 ug ml-1 Compound was tested in vitro for antibacterial activity against the microbial strain E. coli NIHJ JC-2. ChEMBL. 3114492
MIC (functional) = 0.2 ug ml-1 Antibacterial activity against Escherichia coli NIHJ JC-2 ChEMBL. 6422043
MIC (functional) = 0.2 ug ml-1 In vitro antibacterial activity against Escherichia coli NIHJ JC-2 ChEMBL. 6438319
MIC (functional) = 0.2 ug ml-1 Compound was tested for inhibition of the gram-negative organism Escherichia coli vogel ChEMBL. 3007757
MIC (functional) = 0.2 ug ml-1 In vitro antibacterial activity against E. coli KC-14,Ec(K),(gram-negative) ChEMBL. 1310116
MIC (functional) = 0.2 ug ml-1 Activity against E. coli (K-12 C600) ChEMBL. 2163456
MIC (functional) = 0.2 ug ml-1 Activity against E. coli (KC-14) ChEMBL. 2163456
MIC (functional) = 0.2 ug ml-1 Compound was tested in vitro for antibacterial activity against the microbial strain E. coli NIHJ JC-2. ChEMBL. 3114492
MIC (functional) = 0.2 ug ml-1 Antibacterial activity against Escherichia coli NIHJ JC-2 ChEMBL. 6422043
MIC (functional) = 0.25 ug ml-1 In vitro antibacterial activity against Staphylococcus aureus Smith (A9537) ChEMBL. 2918499
MIC (functional) = 0.25 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-3 acrAB::Kan with GyrA S83F, ParC S80I mutation ChEMBL. 17043131
MIC (functional) = 0.25 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS18 acrAB::Kan with GyrA S38F mutation ChEMBL. 17043131
MIC (functional) = 0.39 ug ml-1 Minimum inhibition concentration in vitro determined against Pseudomona aeruginosa 5007 ChEMBL. 3934382
MIC (functional) = 0.39 ug ml-1 Minimum inhibition concentration in vitro determined against Pseudomona aeruginosa K799/WT ChEMBL. 3934382
MIC (functional) = 0.39 ug ml-1 Antibacterial activity against Escherichia coli ATCC 8739 after 18 hrs by agar dilution method ChEMBL. No reference
MIC (functional) = 0.4 ug ml-1 Compound was tested for inhibition of the gram-negative organism Streptococcus aureus UC-76. ChEMBL. 3007757
MIC (functional) = 0.5 ug ml-1 In vitro antibacterial activity against K. pneumoniae (A 9664) ChEMBL. 2918499
MIC (functional) = 0.5 ug ml-1 In vitro antibacterial activity against E. cloacae (A 9656) ChEMBL. 2918499
MIC (functional) = 0.5 ug ml-1 In vitro antibacterial activity against P. aeruginosa (A 9843) ChEMBL. 2918499
MIC (functional) = 0.5 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-1 GyrA S83F mutant ChEMBL. 17043131
MIC (functional) = 0.5 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS18 with GyrA S38F mutation ChEMBL. 17043131
MIC (functional) = 0.78 ug ml-1 In vitro for antibacterial activity against Staphylococcus aureus 209P JC-1 ChEMBL. 6438319
MIC (functional) = 0.78 ug ml-1 in vitro antibacterial activity against Pseudomonas aeruginosa Tsuchijima ChEMBL. 6438319
MIC (functional) = 0.78 ug ml-1 In vitro antibacterial activity against staphylococcus aureus FDA 209P JC-1,Sa(F)(gram-positive) ChEMBL. 1310116
MIC (functional) = 0.78 ug ml-1 In vitro antibacterial activity against staphylococcus aureus IID 803,(gram-positive) ChEMBL. 1310116
MIC (functional) = 0.78 ug ml-1 Activity against S. aureus (FDA207PJC-1) ChEMBL. 2163456
MIC (functional) = 0.78 ug ml-1 Activity against S. aureus (IID 803) ChEMBL. 2163456
MIC (functional) = 0.78 ug ml-1 Minimum inhibition concentration in vitro determined against Staphylococcus aureus ATCC 6538P ChEMBL. 3934382
MIC (functional) = 0.78 ug ml-1 Minimum inhibition concentration in vitro determined against Staphylococcus aureus CMX 686B ChEMBL. 3934382
MIC (functional) = 0.78 ug ml-1 Minimum inhibition concentration in vitro determined against Streptococcus faecium ATCC 8043 ChEMBL. 3934382
MIC (functional) = 0.78 ug ml-1 Compound was tested in vitro for antibacterial activity against the microbial strain S. aureus 209P JC-1. ChEMBL. 3114492
MIC (functional) = 0.78 ug ml-1 Compound was tested in vitro for antibacterial activity against the microbial strain P. aeruginosa 12. ChEMBL. 3114492
MIC (functional) = 0.78 ug ml-1 Antibacterial activity against S. aureus 50774 microbial strains in mice was determined expressed as MIC ChEMBL. 3114492
MIC (functional) = 0.78 ug ml-1 Antibacterial activity against P. aeruginosa 12 microbial strains in mice was determined expressed as MIC ChEMBL. 3114492
MIC (functional) = 0.78 ug ml-1 Antibacterial activity against Staphylococcus aureus 209PJC-1 ChEMBL. 6422043
MIC (functional) = 0.78 ug ml-1 Antibacterial activity against Pseudomonas aeruginosa Tsuchijima ChEMBL. 6422043
MIC (functional) = 0.78 ug ml-1 Antibacterial activity against Staphylococcus epidermidis ATCC 12228 by agar-dilution method ChEMBL. 16644219
MIC (functional) = 0.78 ug ml-1 Antibacterial activity against S. aureus 50774 microbial strains in mice was determined expressed as MIC ChEMBL. 3114492
MIC (functional) = 0.78 ug ml-1 Antibacterial activity against P. aeruginosa 12 microbial strains in mice was determined expressed as MIC ChEMBL. 3114492
MIC (functional) = 0.8 ug ml-1 Antibacterial activity of the compound against Pseudomonas aeruginosa (UI-18) ChEMBL. 3005575
MIC (functional) = 0.8 ug ml-1 Antibacterial activity of the compound against Pseudomonas aeruginosa (UI-18) ChEMBL. 3005575
MIC (functional) = 1 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-2 gyrA+ with ParC S80I mutation ChEMBL. 17043131
MIC (functional) = 1 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS14 with GyrA D87G mutation ChEMBL. 17043131
MIC (functional) = 1 ug ml-1 Antimicrobial activity against Escherichia coli ATCC 25922 by twofold broth dilution method ChEMBL. 21215620
MIC (functional) = 1.56 ug ml-1 In vitro antibacterial activity against Pseudomonas aeruginosa IFO 3445,Pa(I),(gram-negative) ChEMBL. 1310116
MIC (functional) = 1.56 ug ml-1 In vitro antibacterial activity against Pseudomonas aeruginosa E-2,Pa(E),(gram-negative) ChEMBL. 1310116
MIC (functional) = 1.56 ug ml-1 Activity against P. aeruginosa (E-2) ChEMBL. 2163456
MIC (functional) = 1.56 ug ml-1 Minimum inhibition concentration in vitro determined against Staphylococcus epidermidis 3519 ChEMBL. 3934382
MIC (functional) = 1.56 ug ml-1 Antibacterial activity against Staphylococcus aureus ATCC 6538p by agar-dilution method ChEMBL. 16644219
MIC (functional) = 1.6 ug ml-1 Compound was tested for inhibition of the gram-negative organism P. aeruginosa UI-18 ChEMBL. 3007757
MIC (functional) = 1.6 ug ml-1 Compound was tested for inhibition of the gram-negative organism Streptococcus aureus H228. ChEMBL. 3007757
MIC (functional) = 2 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-3 gyrA+ with ParC S80I mutation ChEMBL. 17043131
MIC (functional) = 2 ug ml-1 Antibacterial activity against Escherichia coli JM109 harboring plasmid ptac85-vca0421 ChEMBL. 20805389
MIC (functional) = 3.1 ug ml-1 Compound was tested for inhibition of the gram-negative organism Streptococcus faecalis MGH-2 ChEMBL. 3007757
MIC (functional) = 3.1 ug ml-1 Compound was tested for inhibition of the gram-negative organism Streptococcus pneumoniae SV-1 ChEMBL. 3007757
MIC (functional) = 3.1 ug ml-1 Minimum inhibition concentration in vitro determined against Streptococcus pyogenes 930 ChEMBL. 3934382
MIC (functional) = 3.1 ug ml-1 Antibacterial activity of the compound against Staphylococcus aureus (H228) ChEMBL. 3005575
MIC (functional) = 3.1 ug ml-1 Antibacterial activity of the compound against Streptococcus pneumoniae (SV-1) ChEMBL. 3005575
MIC (functional) = 3.1 ug ml-1 Antibacterial activity of the compound against Staphylococcus aureus (H228) ChEMBL. 3005575
MIC (functional) = 3.1 ug ml-1 Antibacterial activity of the compound against Streptococcus pneumoniae (SV-1) ChEMBL. 3005575
MIC (functional) = 3.13 ug ml-1 In vitro antibacterial activity against staphylococcus epidermidis IAM 1296, (gram-positive) ChEMBL. 1310116
MIC (functional) = 3.13 ug ml-1 In vitro antibacterial activity against E. faecalis IID 682,Ec (N),(gram-positive) ChEMBL. 1310116
MIC (functional) = 3.13 ug ml-1 Activity against S. epidermis (IAM 1296) ChEMBL. 2163456
MIC (functional) = 3.13 ug ml-1 Activity against S. faecalis (IID 682) ChEMBL. 2163456
MIC (functional) = 3.13 ug ml-1 Activity against A. calcoaceticus (AC54) ChEMBL. 2163456
MIC (functional) = 4 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-4 gyrA+ with ParC S80I mutation ChEMBL. 17043131
MIC (functional) = 4 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium CS1 acrAB::Kan with GyrA S83F, D87N, ParC S80I mutation ChEMBL. 17043131
MIC (functional) = 4 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium CS1 tolC::Kan with GyrA S83F, D87N, ParC S80I mutation ChEMBL. 17043131
MIC (functional) = 4 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium CS3 acrAB::Kan with GyrA S83F, D87N, ParC S80I mutation ChEMBL. 17043131
MIC (functional) = 4 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium CS3 tolC::Kan with GyrA S83F, D87N, parC S80I mutation ChEMBL. 17043131
MIC (functional) = 4 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium CS9 acrAB::Kan with GyrA S83F, D87N, ParC S80I mutation ChEMBL. 17043131
MIC (functional) = 4 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium CS9 tolC::Kan with GyrA S83F, D87N, ParC S80I mutation ChEMBL. 17043131
MIC (functional) = 4 ug ml-1 Antibacterial activity against Escherichia coli JM109 harboring plasmid ptac85 ChEMBL. 20805389
MIC (functional) = 5 ug ml-1 MIC of the compound at which cleaved DNA (linear) is observed at an intensity relative to oxolinic acid at 10 microg/mL by using Gyrase Induced DNA-Cleavage assay ChEMBL. 3005575
MIC (functional) = 5 ug ml-1 MIC of the compound at which cleaved DNA (linear) is observed at an intensity relative to oxolinic acid at 10 microg/mL by using Gyrase Induced DNA-Cleavage assay ChEMBL. 3005575
MIC (functional) = 6.2 ug ml-1 Minimum inhibition concentration in vitro determined against Actinetobacter sp CMX669 ChEMBL. 3934382
MIC (functional) = 6.25 ug ml-1 Activity against P. cepacia (IID-1341) ChEMBL. 2163456
MIC (functional) = 6.25 ug ml-1 Antibacterial activity against Pseudomonas aeruginosa ATCC 9027 by agar-dilution method ChEMBL. 16644219
MIC (functional) = 8 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-2 with GyrA S83F, ParC S80I mutation ChEMBL. 17043131
MIC (functional) = 12.5 ug ml-1 Compound was tested for inhibition of the gram-negative organism Streptococcus pyogenes C203. ChEMBL. 3007757
MIC (functional) > 16 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-3 with GyrA S83F, ParC S80I mutation ChEMBL. 17043131
MIC (functional) > 16 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-4 with GyrA S83F, ParC S80I mutation ChEMBL. 17043131
MIC (functional) = 16 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium CS1 with GyrA S83F, D87N, ParC S80I mutation ChEMBL. 17043131
MIC (functional) = 16 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium CS3 with GyrA S83F, D87N, ParC S80I mutation ChEMBL. 17043131
MIC (functional) = 16 ug ml-1 Antimicrobial activity against Salmonella enterica serovar Typhimurium CS9 with GyrA S83F, D87N, ParC S80I mutation ChEMBL. 17043131
Min concentration (binding) = 5 ug ml-1 Inhibition of DNA gyrase of Escherichia coli H560 cells ChEMBL. 3007757
Min concentration (binding) = 5 ug ml-1 Inhibition of DNA gyrase of Escherichia coli H560 cells ChEMBL. 3007757
PD50 (functional) = 2 mg kg-1 Compound was evaluated for protective dose against the Escherichia coli vogel lethal infection following sc administration in mouse ChEMBL. 3007757
PD50 (functional) = 2 mg kg-1 Compound was evaluated for protective dose against the Escherichia coli vogel lethal infection following sc administration in mouse ChEMBL. 3007757
PD50 (functional) = 3 mg kg-1 Compound was evaluated for protective dose against the Escherichia coli vogel lethal infection following peroral administration in mouse ChEMBL. 3007757
PD50 (functional) = 3 mg kg-1 Compound was evaluated for protective dose against the Escherichia coli vogel lethal infection following peroral administration in mouse ChEMBL. 3007757
PD50 (functional) = 10 mg kg-1 Compound was evaluated for protective dose against the Streptococcus aureus UC-76 lethal infection following sc administration in mouse ChEMBL. 3007757
PD50 (functional) = 10 mg kg-1 Compound was evaluated for protective dose against the Streptococcus aureus UC-76 lethal infection following sc administration in mouse ChEMBL. 3007757
PD50 (functional) = 12 mg kg-1 Compound was evaluated for protective dose against the Streptococcus aureus UC-76 lethal infection following po administration in mouse ChEMBL. 3007757
PD50 (functional) = 12 mg kg-1 Compound was evaluated for protective dose against the Streptococcus aureus UC-76 lethal infection following po administration in mouse ChEMBL. 3007757
PD50 (functional) > 100 mg kg-1 Compound was evaluated for protective dose against Streptococcus pneumoniae SV-1 lethal infection following sc administration ChEMBL. 3007757
PD50 (functional) > 100 mg kg-1 Compound was evaluated for protective dose against Streptococcus pneumoniae SV-1 lethal infection following sc administration ChEMBL. 3007757
PD50 (functional) > 200 mg kg-1 Compound was evaluated for protective dose against the Streptococcus pneumoniae SV-1 lethal infection following po administration ChEMBL. 3007757
PD50 (functional) > 200 mg kg-1 Compound was evaluated for protective dose against the Streptococcus pneumoniae SV-1 lethal infection following po administration ChEMBL. 3007757
Permeability (ADMET) BBB penetration classification ChEMBL. 10841799
Permeability (ADMET) 0 BBB penetration classification ChEMBL. 10841799
Potency (functional) 0.1995 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.4382 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.6125 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (ADMET) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9. (Class of assay: confirmatory) [Related pubchem assays: 885, 884, 410 ] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Vdss (ADMET) = 1.96 L/Kg Volume of distribution at steady state in human ChEMBL. 19586686

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Escherichia coli ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Leishmania panamensis 22297  
Annotator: crowther@u.washington.edu Comment: Drug: 16037-91-5 (Sodium stibogluconate). chemical inhibition with topoisomerase inhibitors reduces topoisomerase activity; References: 17466980
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Leishmania panamensis 22658  
Annotator: crowther@u.washington.edu Comment: Drug: 16037-91-5 (Sodium stibogluconate). chemical inhibition with topoisomerase inhibitors reduces topoisomerase activity; References: 17466980
viability (PATO:0000169) decreased (PATO:0000468) single cell organism (CARO:0000064) amastigote (BTO:0000062) host (GO:0018995) Leishmania panamensis 22297  
Annotator: crowther@u.washington.edu Comment: chemical inhibition with topoisomerase inhibitors reduces viability of amastigotes inside human macrophages References: 16539034
viability (PATO:0000169) decreased (PATO:0000468) single cell organism (CARO:0000064) amastigote (BTO:0000062) host (GO:0018995) Leishmania panamensis 22658  
Annotator: crowther@u.washington.edu Comment: chemical inhibition with topoisomerase inhibitors reduces viability of amastigotes inside human macrophages References: 16539034
viability (PATO:0000169) decreased (PATO:0000468) single cell organism (CARO:0000064) amastigote (BTO:0000062) inferred from bioassay (ECO:0000094) Leishmania panamensis 22297  
Annotator: crowther@u.washington.edu Comment: chemical inhibition with topoisomerase inhibitors reduces viability of amastigotes inside human macrophages References: 16539034
viability (PATO:0000169) decreased (PATO:0000468) single cell organism (CARO:0000064) amastigote (BTO:0000062) inferred from bioassay (ECO:0000094) Leishmania panamensis 22658  
Annotator: crowther@u.washington.edu Comment: chemical inhibition with topoisomerase inhibitors reduces viability of amastigotes inside human macrophages References: 16539034
growth (GO:0040007) drug insensitive (PATO:0000528) inferred from in vitro culture assay (ECO:0000182) Mycobacterium tuberculosis 6193  
Annotator: crowther@u.washington.edu Comment: 2007-12-04 References: 16377674
catalytic activity (GO:0003824) drug insensitive (PATO:0000528) in vitro (MI:0492) inferred from enzyme assay (ECO:0000005) Mycobacterium tuberculosis 6193  
Annotator: crowther@u.washington.edu Comment: 2007-12-04 References: 16377674
growth (GO:0040007) drug insensitive (PATO:0000528) inferred from in vitro culture assay (ECO:0000182) Mycobacterium tuberculosis 6194  
Annotator: crowther@u.washington.edu Comment: 2007-12-04 References: 16377674
catalytic activity (GO:0003824) drug insensitive (PATO:0000528) in vitro (MI:0492) inferred from enzyme assay (ECO:0000005) Mycobacterium tuberculosis 6194  
Annotator: crowther@u.washington.edu Comment: 2007-12-04 References: 16377674

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

29 literature references were collected for this gene.

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