TDR Targets

Basic information

Technical information

TDR Targets ID: 1067614
Name: 3-chloro-4-fluoro-N-[2-oxo-2-(1-pyrrolidinyl) ethyl]benzenesulfonamide
MW: 320.768 | Formula: C12H14ClFN2O3S
H donors: 1 H acceptors: 3 LogP: 1.63 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N1CCCC1)CNS(=O)(=O)c1ccc(c(c1)Cl)F
InChi: 1S/C12H14ClFN2O3S/c13-10-7-9(3-4-11(10)14)20(18,19)15-8-12(17)16-5-1-2-6-16/h3-4,7,15H,1-2,5-6,8H2
InChiKey: QVQZABZYIQDYCQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

MLS001179077
SMR000477853
ZINC00387315
T5890225
AQ-750/42594751

Targets

Known targets for this compound

Species	Target name	Bibliographic reference
Homo sapiens	snurportin 1	No references
Homo sapiens	RAN, member RAS oncogene family	No references
Homo sapiens	karyopherin (importin) beta 1	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Leishmania mexicana	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Importin subunit beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_131808	All targets in OG5_131808
Cryptosporidium parvum	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania braziliensis	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium yoelii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	importin beta-1	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	RNA, U transporter 1	Get druggable targets OG5_131808	All targets in OG5_131808
Schistosoma japonicum	ko:K07936 GTP-binding nuclear protein Ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium falciparum	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania infantum	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Snurportin-1, putative	Get druggable targets OG5_131808	All targets in OG5_131808
Cryptosporidium hominis	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei gambiense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma congolense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma congolense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium hominis	importin-beta2	Get druggable targets OG5_127843	All targets in OG5_127843
Neospora caninum	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Theileria parva	GTP-binding nuclear protein ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium yoelii	importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei gambiense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Neospora caninum	GTP-binding nuclear protein Ran, related	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania braziliensis	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania mexicana	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Brugia malayi	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Entamoeba histolytica	Ran family GTPase	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania donovani	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania infantum	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Babesia bovis	GTP-binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma cruzi	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania major	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Importin subunit beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium knowlesi	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium parvum	importin/karyopherin	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania donovani	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania major	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	Get druggable targets OG5_131808	All targets in OG5_131808
Echinococcus granulosus	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Theileria parva	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium vivax	importin-beta 2, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium berghei	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Toxoplasma gondii	HEAT repeat-containing protein	Get druggable targets OG5_127843	All targets in OG5_127843
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium knowlesi	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium berghei	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	importin beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Brugia malayi	Importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Babesia bovis	importin beta subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0074	0.058	0.1323
Giardia lamblia	Cathepsin B precursor	0.0106	0.0991	1
Echinococcus granulosus	inhibitor of apoptosis protein	0.0357	0.4189	0.9551
Entamoeba histolytica	cysteine protease, putative	0.0074	0.058	1
Echinococcus multilocularis	GPCR, family 2	0.0048	0.025	0.0167
Entamoeba histolytica	hypothetical protein	0.0036	0.0099	0.1714
Loa Loa (eye worm)	gamma-secretase subunit aph-1	0.024	0.2706	0.6174
Brugia malayi	intermediate filament protein	0.0053	0.0314	0.0747
Schistosoma mansoni	inhibitor of apoptosis protein	0.0357	0.4189	0.9184
Echinococcus granulosus	gamma secretase subunit aph 1	0.024	0.2706	0.61
Brugia malayi	Cathepsin L-like precursor	0.0074	0.058	0.1383
Entamoeba histolytica	hypothetical protein	0.0036	0.0099	0.1714
Trypanosoma cruzi	Aph-1 protein, putative	0.0094	0.0835	0.2555
Schistosoma mansoni	histone deacetylase 4 5	0.0042	0.0181	0.0217
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0037	0.0113	0.0066
Schistosoma mansoni	hypothetical protein	0.0048	0.025	0.0371
Echinococcus multilocularis	geminin	0.0168	0.1779	0.1709
Schistosoma mansoni	histone deacetylase hda2	0.0042	0.0181	0.0217
Trypanosoma cruzi	cysteine peptidase, putative	0.0074	0.058	0.1777
Plasmodium vivax	ataxin-2 like protein, putative	0.0051	0.0285	0.4042
Echinococcus granulosus	short transient receptor potential channel 6	0.0064	0.045	0.0852
Echinococcus multilocularis	neuropeptides capa receptor	0.0226	0.2528	0.2464
Loa Loa (eye worm)	hypothetical protein	0.0074	0.058	0.1323
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0037	0.0113	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.058	0.5853
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0074	0.058	0.1154
Trypanosoma brucei	histone deacetylase, putative	0.0042	0.0181	0.1068
Loa Loa (eye worm)	hypothetical protein	0.0191	0.2079	0.4744
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.058	0.5469
Toxoplasma gondii	histone deacetylase HDAC1	0.0042	0.0181	0.1068
Trypanosoma cruzi	histone deacetylase, putative	0.0042	0.0181	0.0554
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0236	0.0562
Schistosoma mansoni	hypothetical protein	0.0048	0.025	0.0371
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0224	0.0314
Loa Loa (eye worm)	intermediate filament protein	0.0053	0.0314	0.0714
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.058	0.5853
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0224	0.0314
Echinococcus multilocularis	baculoviral IAP repeat containing protein	0.0357	0.4189	0.414
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0357	0.4189	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0037	0.0113	0.0575
Echinococcus multilocularis	histone deacetylase 6	0.0042	0.0181	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0314	0.0714
Loa Loa (eye worm)	hypothetical protein	0.0191	0.2079	0.4744
Onchocerca volvulus	Cathepsin L homolog	0.0074	0.058	0.0871
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0224	0.051
Brugia malayi	Cathepsin L-like precursor	0.0074	0.058	0.1383
Echinococcus multilocularis	cysteine protease	0.0074	0.058	0.05
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.058	0.5469
Giardia lamblia	Cathepsin B precursor	0.0106	0.0991	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0074	0.058	0.05
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0224	0.0326
Echinococcus granulosus	histone deacetylase 6	0.0042	0.0181	0.0225
Trypanosoma cruzi	cysteine peptidase, putative	0.0074	0.058	0.1777
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0181	0.0411
Entamoeba histolytica	cysteine proteinase, putative	0.0074	0.058	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.058	0.5469
Trypanosoma brucei	Aph-1 protein, putative	0.0094	0.0835	0.8272
Giardia lamblia	Cathepsin B precursor	0.0106	0.0991	1
Schistosoma mansoni	histone deacetylase 4 5	0.0042	0.0181	0.0217
Brugia malayi	cathepsin B-like cysteine proteinase	0.0284	0.3266	0.7795
Echinococcus multilocularis	lamin dm0	0.0053	0.0314	0.0232
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.058	0.5853
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0037	0.0113	0.5
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0048	0.025	0.0595
Trypanosoma brucei	histone deacetylase 4	0.0042	0.0181	0.1068
Echinococcus granulosus	caspase 2	0.0191	0.2079	0.4642
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0301	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1569	0.3578
Brugia malayi	Cathepsin L-like precursor	0.0074	0.058	0.1383
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0074	0.058	0.05
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0181	0.0411
Schistosoma mansoni	gamma-secretase subunit aph-1	0.024	0.2706	0.5865
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.058	0.5469
Schistosoma mansoni	hypothetical protein	0.0103	0.0958	0.1956
Echinococcus multilocularis	cathepsin b	0.0284	0.3266	0.3209
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0099	0.0036
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.058	0.5469
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0958	0.2185
Echinococcus multilocularis	inhibitor of apoptosis protein	0.0357	0.4189	0.414
Echinococcus granulosus	TRP transient receptor potential channel	0.0036	0.0096	0.0027
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.058	0.5469
Brugia malayi	cathepsin L-like precursor	0.0074	0.058	0.1383
Echinococcus granulosus	transient receptor potential gamma protein	0.0096	0.0865	0.1817
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0048	0.025	0.0569
Brugia malayi	Cathepsin L-like precursor	0.0074	0.058	0.1383
Trypanosoma cruzi	cruzipain precursor, putative	0.0074	0.058	0.1777
Loa Loa (eye worm)	ctsf protein	0.0074	0.058	0.1323
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0036	0.0096	0.0012
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0284	0.3266	0.7118
Echinococcus granulosus	histone deacetylase 6	0.0042	0.0181	0.0225
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.058	0.5853
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.058	0.5853
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0048	0.025	0.0167
Schistosoma mansoni	P2X receptor subunit	0.0066	0.0487	0.0901
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0106	0.0991	1
Loa Loa (eye worm)	histone deacetylase 7A	0.0042	0.0181	0.0411
Echinococcus granulosus	cathepsin b	0.0284	0.3266	0.7403
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0037	0.0113	0.5
Loa Loa (eye worm)	hypothetical protein	0.0074	0.058	0.1323
Echinococcus multilocularis	short transient receptor potential channel 6	0.0064	0.045	0.0369
Loa Loa (eye worm)	cysteine protease	0.0074	0.058	0.1323
Schistosoma mansoni	cathepsin F (C01 family)	0.0074	0.058	0.111
Schistosoma mansoni	caspase-7 (C14 family)	0.0191	0.2079	0.4464
Brugia malayi	hypothetical protein	0.0036	0.0099	0.0236
Echinococcus granulosus	geminin	0.0168	0.1779	0.3944
Leishmania major	cathepsin L-like protease	0.0074	0.058	0.5853
Echinococcus multilocularis	lamin	0.0053	0.0314	0.0232
Leishmania major	hypothetical protein, conserved	0.0051	0.0285	0.2871
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0084	0.019
Echinococcus granulosus	cathepsin b	0.0284	0.3266	0.7403
Loa Loa (eye worm)	histone deacetylase	0.0042	0.0181	0.0411
Echinococcus granulosus	GPCR family 2	0.0048	0.025	0.0386
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.058	0.5853
Schistosoma mansoni	transient receptor potential channel	0.0064	0.045	0.0819
Trichomonas vaginalis	ap endonuclease, putative	0.0037	0.0113	0.1136
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.058	0.5853
Echinococcus granulosus	p2X purinoceptor 4	0.0066	0.0487	0.0937
Onchocerca volvulus		0.0074	0.058	0.0871
Toxoplasma gondii	cathepsin CPL	0.0074	0.058	0.5469
Schistosoma mansoni	P2X receptor subunit	0.0066	0.0487	0.0901
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0285	0.0871
Echinococcus multilocularis	histone deacetylase 7	0.0042	0.0181	0.0098
Trypanosoma brucei	histone deacetylase 3	0.0042	0.0181	0.1068
Brugia malayi	hypothetical protein	0.0229	0.2563	0.6118
Schistosoma mansoni	ap endonuclease	0.0037	0.0113	0.0064
Schistosoma mansoni	hypothetical protein	0.0168	0.1779	0.3792
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0037	0.0113	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0055	0.0123
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.058	0.5853
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.0285	0.4042
Schistosoma mansoni	amine GPCR	0.0385	0.4554	1
Plasmodium vivax	histone deacetylase, putative	0.0042	0.0181	0.1953
Toxoplasma gondii	LsmAD domain-containing protein	0.0051	0.0285	0.2211
Onchocerca volvulus		0.0074	0.058	0.0871
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0224	0.0141
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0037	0.0113	0.0575
Brugia malayi	Transient-receptor-potential like protein	0.0036	0.0096	0.0226
Trypanosoma brucei	PAB1-binding protein , putative	0.0051	0.0285	0.2211
Trypanosoma cruzi	histone deacetylase, putative	0.0042	0.0181	0.0554
Trypanosoma cruzi	cysteine peptidase, putative	0.0074	0.058	0.1777
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0151	0.1569	0.3743
Loa Loa (eye worm)	hypothetical protein	0.0229	0.2563	0.5849
Echinococcus multilocularis	histone deacetylase 6	0.0042	0.0181	0.0098
Schistosoma mansoni	transient receptor potential channel 4	0.0096	0.0865	0.1747
Leishmania major	cathepsin L-like protease	0.0074	0.058	0.5853
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.058	0.5853
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0037	0.0113	0.0345
Onchocerca volvulus		0.0074	0.058	0.0871
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0074	0.058	0.1323
Schistosoma mansoni	intermediate filament proteins	0.0053	0.0314	0.0514
Echinococcus multilocularis	caspase 2	0.0191	0.2079	0.2012
Echinococcus granulosus	baculoviral IAP repeat containing protein	0.0357	0.4189	0.9551
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0285	0.0871
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0224	0.0314
Schistosoma mansoni	hypothetical protein	0.0048	0.025	0.0371
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0037	0.0113	0.0345
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0037	0.0113	0.5
Schistosoma mansoni	hypothetical protein	0.0036	0.0099	0.0034
Brugia malayi	Latrophilin receptor protein 2	0.0048	0.025	0.0595
Leishmania major	histone deacetylase, putative	0.0042	0.0181	0.1825
Brugia malayi	Cell death protein 3 precursor	0.0191	0.2079	0.4963
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0106	0.0991	0.3035
Echinococcus multilocularis	gamma secretase subunit aph 1	0.024	0.2706	0.2644
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0106	0.0991	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.058	0.5853
Trypanosoma cruzi	Aph-1 protein, putative	0.0094	0.0835	0.2555
Plasmodium falciparum	histone deacetylase 2	0.0042	0.0181	0.1953
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0865	0.1973
Brugia malayi	Histone deacetylase family protein	0.0042	0.0181	0.043
Echinococcus multilocularis	p2X purinoceptor 4	0.0066	0.0487	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0357	0.4189	0.956
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0074	0.058	1
Schistosoma mansoni	transient receptor potential channel	0.0096	0.0865	0.1747
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.058	0.5853
Schistosoma mansoni	hypothetical protein	0.0047	0.0236	0.034
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0284	0.3266	0.7118
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0236	0.034
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.058	0.5853
Echinococcus granulosus	neuropeptides capa receptor	0.0226	0.2528	0.5685
Schistosoma mansoni	hypothetical protein	0.0191	0.2079	0.4464
Loa Loa (eye worm)	hypothetical protein	0.0284	0.3266	0.7452
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.058	0.5853
Brugia malayi	latrophilin 2 splice variant baaae	0.0103	0.0958	0.2286
Brugia malayi	Papain family cysteine protease containing protein	0.0074	0.058	0.1383
Onchocerca volvulus		0.0074	0.058	0.0871
Plasmodium vivax	vivapain-2	0.0074	0.058	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0224	0.0326
Leishmania major	cathepsin L-like protease	0.0074	0.058	0.5853
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.058	0.5469
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.058	0.5853
Echinococcus multilocularis	transient receptor potential gamma protein	0.0096	0.0865	0.0788
Loa Loa (eye worm)	hypothetical protein	0.0074	0.058	0.1323
Echinococcus multilocularis	cathepsin b	0.0284	0.3266	0.3209
Echinococcus granulosus	cathepsin l1	0.0074	0.058	0.1154
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0053	0.0314	0.0714
Echinococcus granulosus	lamin dm0	0.0053	0.0314	0.0534
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0074	0.058	1
Echinococcus multilocularis	apoptotic protease activating factor 1	0.0191	0.2079	0.2012
Leishmania major	cathepsin L-like protease	0.0074	0.058	0.5853
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0048	0.025	0.0167
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.058	0.5853
Echinococcus multilocularis	cathepsin L cysteine protease	0.0074	0.058	0.05
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0096	0.0216
Onchocerca volvulus		0.0074	0.058	0.0871
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.058	0.5853
Schistosoma mansoni	lamin	0.0053	0.0314	0.0514
Onchocerca volvulus		0.0053	0.0314	0.0196
Echinococcus granulosus	histone deacetylase 6	0.0042	0.0181	0.0225
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0048	0.025	0.0386
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0224	0.0533
Echinococcus granulosus	histone deacetylase	0.0042	0.0181	0.0225
Schistosoma mansoni	P2X receptor subunit	0.0066	0.0487	0.0901
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.058	0.5853
Echinococcus multilocularis	histone deacetylase 6	0.0042	0.0181	0.0098
Schistosoma mansoni	hypothetical protein	0.0168	0.1779	0.3792
Entamoeba histolytica	hypothetical protein	0.0036	0.0099	0.1714
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0284	0.3266	0.7118
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0074	0.058	0.5853
Loa Loa (eye worm)	fibroinase	0.0074	0.058	0.1323
Echinococcus granulosus	apoptotic protease activating factor 1	0.0191	0.2079	0.4642
Onchocerca volvulus		0.0191	0.2079	0.4663
Echinococcus multilocularis	transient receptor potential ion channel A	0.0093	0.0824	0.0747
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.058	0.5853
Entamoeba histolytica	hypothetical protein	0.0036	0.0099	0.1714
Leishmania major	cysteine peptidase A (CPA)	0.0074	0.058	0.5853
Loa Loa (eye worm)	cathepsin B	0.0106	0.0991	0.2261
Echinococcus granulosus	histone deacetylase 7	0.0042	0.0181	0.0225
Echinococcus granulosus	p2X purinoceptor 4	0.0066	0.0487	0.0937
Onchocerca volvulus	Cell death protein 3 homolog	0.0191	0.2079	0.4663
Brugia malayi	hypothetical protein	0.0033	0.0056	0.0132
Leishmania major	cathepsin L-like protease	0.0074	0.058	0.5853
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0106	0.0991	0.203
Trichomonas vaginalis	ap endonuclease, putative	0.0037	0.0113	0.1136
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.058	0.5853
Brugia malayi	Cathepsin L-like precursor	0.0074	0.058	0.1383
Echinococcus multilocularis	p2X purinoceptor 4	0.0066	0.0487	0.0406
Onchocerca volvulus		0.0357	0.4189	1
Echinococcus granulosus	survival motor neuron protein 1	0.0229	0.2563	0.5768
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.058	0.5853
Brugia malayi	exodeoxyribonuclease III family protein	0.0037	0.0113	0.0267
Echinococcus multilocularis	survival motor neuron protein 1	0.0229	0.2563	0.25
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0037	0.0113	0.1136
Schistosoma mansoni	cathepsin F (C01 family)	0.0074	0.058	0.111
Leishmania major	cathepsin L-like protease	0.0074	0.058	0.5853
Brugia malayi	hypothetical protein	0.0051	0.0285	0.0678
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.058	0.5469
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0372	0.4382	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0074	0.058	0.1383
Brugia malayi	RNA, U transporter 1	0.0099	0.0903	0.2154
Onchocerca volvulus	Cathepsin F homolog	0.0074	0.058	0.0871
Schistosoma mansoni	lamin	0.0053	0.0314	0.0514
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0074	0.058	0.5853
Brugia malayi	Intermediate filament tail domain containing protein	0.0053	0.0314	0.0747
Echinococcus multilocularis	musashi	0.0053	0.0314	0.0232
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.058	0.5853
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0074	0.058	0.1777
Plasmodium falciparum	histone deacetylase, putative	0.0042	0.0181	0.1953
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0284	0.3266	1
Entamoeba histolytica	cysteine proteinase, putative	0.0074	0.058	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0074	0.058	0.1323
Echinococcus granulosus	snurportin 1	0.0372	0.4382	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0284	0.3266	0.7118
Schistosoma mansoni	P2X receptor subunit	0.0066	0.0487	0.0901
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0357	0.4189	1
Echinococcus granulosus	short transient receptor potential channel 6	0.0064	0.045	0.0852
Schistosoma mansoni	transient receptor potential channel	0.0064	0.045	0.0819
Echinococcus granulosus	lamin	0.0053	0.0314	0.0534
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.058	0.5469
Echinococcus multilocularis	cysteine protease	0.0074	0.058	0.05
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0037	0.0113	0.0029
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0151	0.1569	0.3578
Toxoplasma gondii	cathepsin B	0.0106	0.0991	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.058	0.5853
Leishmania major	histone deacetylase, putative	0.0042	0.0181	0.1825
Onchocerca volvulus	Deterin homolog	0.0357	0.4189	1
Schistosoma mansoni	hypothetical protein	0.0357	0.4189	0.9184
Echinococcus granulosus	cathepsin l1	0.0074	0.058	0.1154
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0074	0.058	0.1154
Echinococcus multilocularis	p2X purinoceptor 4	0.0066	0.0487	0.0406
Onchocerca volvulus		0.0074	0.058	0.0871
Echinococcus multilocularis	snurportin 1	0.0372	0.4382	0.4335
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.058	0.5853
Trypanosoma cruzi	cysteine peptidase, putative	0.0074	0.058	0.1777
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.058	0.5853
Trypanosoma cruzi	histone deacetylase, putative	0.0042	0.0181	0.0554
Echinococcus granulosus	p2X purinoceptor 4	0.0066	0.0487	0.0937
Loa Loa (eye worm)	hypothetical protein	0.0048	0.025	0.0569
Entamoeba histolytica	cysteine proteinase, putative	0.0074	0.058	1
Brugia malayi	gamma-secretase subunit aph-1	0.024	0.2706	0.6458
Brugia malayi	Cathepsin L-like precursor	0.0074	0.058	0.1383
Schistosoma mansoni	hypothetical protein	0.0048	0.025	0.0371
Brugia malayi	Cathepsin L-like precursor	0.0074	0.058	0.1383
Toxoplasma gondii	exonuclease III APE	0.0037	0.0113	0.0315
Plasmodium vivax	histone deacetylase 2, putative	0.0042	0.0181	0.1953
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0074	0.058	1
Brugia malayi	hypothetical protein	0.0191	0.2079	0.4963
Echinococcus multilocularis	histone deacetylase	0.0042	0.0181	0.0098
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0099	0.0034
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0099	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0285	0.0648
Schistosoma mansoni	ap endonuclease	0.0037	0.0113	0.0064
Echinococcus granulosus	transient receptor potential ion channel A	0.0093	0.0824	0.1722
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.0285	0.4042
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.058	0.5469
Onchocerca volvulus		0.0074	0.058	0.0871
Echinococcus multilocularis	short transient receptor potential channel 6	0.0064	0.045	0.0369
Schistosoma mansoni	cathepsin F (C01 family)	0.0074	0.058	0.111
Schistosoma mansoni	hypothetical protein	0.0372	0.4382	0.9616
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0106	0.0991	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0409	0.0933
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.058	0.5469
Schistosoma mansoni	inhibitor of apoptosis (iap) domain family member	0.0357	0.4189	0.9184
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0037	0.0113	0.194
Loa Loa (eye worm)	hypothetical protein	0.0357	0.4189	0.956
Onchocerca volvulus		0.0053	0.0314	0.0196
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0224	0.0141
Echinococcus granulosus	intermediate filament protein	0.0053	0.0314	0.0534
Plasmodium vivax	vivapain-2	0.0074	0.058	1
Brugia malayi	Cathepsin L-like precursor	0.0074	0.058	0.1383
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.058	0.5853
Onchocerca volvulus		0.0074	0.058	0.0871
Onchocerca volvulus	Cathepsin L homolog	0.0074	0.058	0.0871
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0074	0.058	0.05
Brugia malayi	Importin beta-1 subunit	0.0035	0.0084	0.0199
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0048	0.025	0.0386
Leishmania major	cathepsin L-like protease	0.0074	0.058	0.5853
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0151	0.1569	0.3743
Brugia malayi	Histone deacetylase family protein	0.0042	0.0181	0.043
Leishmania major	cathepsin L-like protease	0.0074	0.058	0.5853
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0037	0.0113	0.0255

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.5805 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262]	ChEMBL.	No reference
Potency (functional)	20.5962 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1867359

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1067614