Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.3825 | 0.5 |
Giardia lamblia | Kinase, PLK | 0.0114 | 0.3825 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.3825 | 0.5 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 0.3825 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.3825 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 0.3825 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.3825 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.3825 | 0.3825 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.3825 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.3825 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.3825 | 0.5 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0114 | 0.3825 | 0.5 |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 0.3825 | 0.5 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 0.3825 | 0.5 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0114 | 0.3825 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.3825 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.3825 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0058 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.8876 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.