Detailed information for compound 1068021

Basic information

Technical information
  • TDR Targets ID: 1068021
  • Name: ethyl (3Z)-3-(pyridine-4-carbonylhydrazinylid ene)hexanoate
  • MW: 277.319 | Formula: C14H19N3O3
  • H donors: 1 H acceptors: 3 LogP: 1.54 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC/C(=N/NC(=O)c1ccncc1)/CC(=O)OCC
  • InChi: 1S/C14H19N3O3/c1-3-5-12(10-13(18)20-4-2)16-17-14(19)11-6-8-15-9-7-11/h6-9H,3-5,10H2,1-2H3,(H,17,19)/b16-12-
  • InChiKey: PICANDUIQSNZJI-VBKFSLOCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl (3Z)-3-(pyridine-4-carbonylhydrazono)hexanoate
  • (3Z)-3-[[oxo-(4-pyridyl)methyl]hydrazono]hexanoic acid ethyl ester
  • (3Z)-3-(pyridine-4-carbonylhydrazono)hexanoic acid ethyl ester
  • ethyl (3Z)-3-(pyridin-4-ylcarbonylhydrazinylidene)hexanoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.008 0.0616 0.0616
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0206 0.0277
Echinococcus granulosus thioredoxin glutathione reductase 0.008 0.0615 0.0897
Plasmodium vivax ataxin-2 like protein, putative 0.0023 0.0074 0.0161
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0052 0.0044
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0254 0.0751
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0023 0.0066 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0241 0.0712
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0231 0.0729
Loa Loa (eye worm) hypothetical protein 0.0075 0.0574 0.0574
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0254 0.0259
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0174 0.1522 0.4498
Loa Loa (eye worm) hypothetical protein 0.0075 0.0574 0.0574
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0054 0.0365 0.0517
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0052 0.0166
Onchocerca volvulus 0.0048 0.0311 0.0311
Onchocerca volvulus 0.0075 0.0574 0.0574
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.0829 0.0904
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0226 0.0307
Brugia malayi Phosphoglycerate kinase 0.0127 0.1067 0.1067
Brugia malayi Muscleblind-like protein 0.031 0.2829 0.2829
Onchocerca volvulus 0.0075 0.0574 0.0574
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0066 0.0066
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0062 0.0442 0.1307
Trichomonas vaginalis mercuric reductase, putative 0.0027 0.0111 0.0351
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0023 0.0066 0.0096
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0066 0.0096
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0254 0.0803
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0066 0.0066
Plasmodium vivax thioredoxin reductase, putative 0.0079 0.0605 0.185
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0024 0.0024
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0023 0.0066 0.0066
Plasmodium falciparum phosphoglycerate kinase 0.0345 0.3167 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0574 0.0835
Entamoeba histolytica hypothetical protein 0.0021 0.0052 0.0166
Loa Loa (eye worm) hypothetical protein 0.0075 0.0574 0.0574
Entamoeba histolytica hypothetical protein 0.0034 0.0172 0.0544
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0589 0.0589
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0062 0.0442 0.1307
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0241 0.0487
Leishmania major DNA polymerase kappa, putative 0.0041 0.0241 0.0712
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0113 0.0285
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0574 0.1235
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0027 0.0111 0.0278
Brugia malayi hypothetical protein 0.0021 0.0052 0.0052
Schistosoma mansoni glutaminase 0.0292 0.2656 0.3992
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0616 0.1712
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0052 0.0044
Loa Loa (eye worm) hypothetical protein 0.0143 0.1229 0.1229
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0241 0.0712
Plasmodium falciparum thioredoxin reductase 0.0027 0.0111 0.0278
Loa Loa (eye worm) hypothetical protein 0.0345 0.3167 0.3167
Trichomonas vaginalis esterase, putative 0.0075 0.0574 0.1814
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0204 0.0274
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0352 0.0498
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0052 0.0044
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.0036 0.0028
Mycobacterium ulcerans glutaminase 0.0292 0.2656 0.835
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0241 0.0329
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0066 0.0096
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0107 0.0339
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0057 0.0402 0.1083
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0027 0.0111 0.0328
Loa Loa (eye worm) hypothetical protein 0.0057 0.0402 0.0402
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0023 0.0066 0.0136
Entamoeba histolytica hypothetical protein 0.0025 0.0089 0.0281
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0052 0.0052
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0148 0.0397
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0023 0.0066 0.0196
Onchocerca volvulus 0.0089 0.0703 0.0703
Onchocerca volvulus 0.0289 0.2628 0.2628
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0062 0.0442 0.047
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0352 0.0736
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0027 0.0111 0.0111
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0231 0.0232
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0574 0.1697
Echinococcus granulosus neuropeptide s receptor 0.054 0.5049 0.7622
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.0074 0.022
Echinococcus multilocularis phosphoglycerate kinase 1 0.0345 0.3167 0.3526
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0574 0.0574
Plasmodium vivax glutathione reductase, putative 0.0079 0.0605 0.185
Leishmania major importin beta-1 subunit, putative 0.0027 0.0107 0.0318
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0616 0.1772
Schistosoma mansoni hypothetical protein 0.0048 0.0311 0.0436
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0077 0.0589 0.1686
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0211 0.021
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0027 0.0111 0.0278
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0044 0.0269 0.078
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0168 0.0162
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0052 0.0044
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0179 0.1574 0.3476
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0241 0.0563
Entamoeba histolytica hypothetical protein 0.0027 0.0107 0.0339
Echinococcus multilocularis neuropeptide s receptor 0.054 0.5049 0.5636
Trypanosoma brucei trypanothione reductase 0.0079 0.0605 0.1788
Brugia malayi Thioredoxin reductase 0.0079 0.0605 0.0605
Schistosoma mansoni alpha glucosidase 0.0042 0.0254 0.035
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0052 0.0044
Schistosoma mansoni phosphoglycerate kinase 0.0345 0.3167 0.4768
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0062 0.0442 0.0635
Plasmodium falciparum acyl-CoA synthetase 0.0057 0.0402 0.1204
Trypanosoma brucei DNA polymerase eta, putative 0.0072 0.0539 0.1593
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0574 0.1235
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0179 0.1574 0.4862
Mycobacterium tuberculosis Conserved hypothetical protein 0.0194 0.1711 0.3784
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0574 0.0618
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0345 0.3167 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0241 0.0712
Trichomonas vaginalis glutaminase, putative 0.0292 0.2656 0.8385
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0206 0.0205
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0027 0.0111 0.0328
Brugia malayi CXXC zinc finger family protein 0.0027 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0033 0.0168 0.0168
Brugia malayi PXA domain containing protein 0.0021 0.0052 0.0052
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0206 0.0205
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0241 0.0712
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0023 0.0066 0.0065
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0499 0.0722
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0206 0.0652
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.0616 0.0898
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0052 0.0044
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0254 0.0803
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0174 0.1522 0.4498
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0089 0.0208
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0231 0.0729
Toxoplasma gondii histone lysine methyltransferase SET1 0.0052 0.0351 0.1041
Loa Loa (eye worm) hypothetical protein 0.0072 0.0539 0.0539
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0228 0.0721
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0052 0.0032
Mycobacterium ulcerans hypothetical protein 0.0077 0.0589 0.1686
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0107 0.0339
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.0616 0.1884
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0574 0.1752
Plasmodium falciparum phd finger protein, putative 0.0031 0.0148 0.0397
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0066 0.0196
Trichomonas vaginalis set domain proteins, putative 0.0289 0.2628 0.8297
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0574 0.1639
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0168 0.0496
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0241 0.0712
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0023 0.0066 0.0096
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0052 0.0346 0.1023
Brugia malayi hypothetical protein 0.0021 0.0052 0.0052
Entamoeba histolytica hypothetical protein 0.0034 0.0172 0.0544
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0345 0.3167 1
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0052 0.0044
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0254 0.0751
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0367 0.3385 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0228 0.0522
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.0616 0.1712
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0052 0.0044
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0206 0.061
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0148 0.014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0372 0.0781
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0023 0.0066 0.0136
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0089 0.0073
Onchocerca volvulus Huntingtin homolog 0.0143 0.1229 0.1229
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0574 0.1235
Toxoplasma gondii hypothetical protein 0.0059 0.0419 0.1258
Loa Loa (eye worm) thioredoxin reductase 0.0079 0.0605 0.0605
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0499 0.0499
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0254 0.0803
Onchocerca volvulus 0.0075 0.0574 0.0574
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0345 0.3167 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0119 0.0352
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0241 0.0241
Schistosoma mansoni ap endonuclease 0.004 0.0231 0.0314
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0372 0.0781
Loa Loa (eye worm) hypothetical protein 0.0236 0.2116 0.2116
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0052 0.0032
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0027 0.0111 0.0071
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0039 0.0039
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0107 0.0318
Loa Loa (eye worm) hypothetical protein 0.0037 0.0204 0.0204
Entamoeba histolytica acyl-coA synthetase, putative 0.0077 0.0589 0.186
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0027 0.0111 0.0278
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0352 0.0736
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0206 0.0205
Echinococcus granulosus tar DNA binding protein 0.0068 0.0499 0.0722
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0186 0.0246
Onchocerca volvulus 0.0077 0.0589 0.0589
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0311 0.0311
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0111 0.0328
Echinococcus granulosus snurportin 1 0.0354 0.3252 0.4896
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0052 0.0032
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0066 0.0196
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0089 0.0073
Brugia malayi TAR-binding protein 0.0068 0.0499 0.0499
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0241 0.0712
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0148 0.0189
Echinococcus granulosus transcription factor Dp 1 0.0036 0.0193 0.0256
Brugia malayi hypothetical protein 0.0143 0.1229 0.1229
Entamoeba histolytica hypothetical protein 0.0034 0.0172 0.0544
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0628 0.0916
Loa Loa (eye worm) hypothetical protein 0.0057 0.0402 0.0402
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0574 0.1235
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0228 0.0674
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0206 0.0277
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0168 0.0496
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0023 0.0066 0.0096
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0231 0.0531
Loa Loa (eye worm) hypothetical protein 0.0023 0.0074 0.0074
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0052 0.0032
Echinococcus granulosus phosphoglycerate kinase 1 0.0345 0.3167 0.4768
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0574 0.0835
Toxoplasma gondii NADPH-glutathione reductase 0.0027 0.0111 0.0278
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0024 0.007
Schistosoma mansoni cpg binding protein 0.0028 0.0122 0.0149
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0089 0.0073
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0089 0.0703 0.103
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.0616 0.0664
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0062 0.0442 0.0635
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0189 0.0394
Schistosoma mansoni acetyl-CoA synthetase 0.0023 0.0066 0.0065
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0372 0.0781
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0204 0.0274
Mycobacterium tuberculosis Probable reductase 0.0179 0.1574 0.3476
Echinococcus multilocularis Protein lozenge 0.0132 0.1122 0.1232
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0254 0.035
Mycobacterium ulcerans lipase LipD 0.0075 0.0574 0.1639
Brugia malayi Probable ClpP-like protease 0.008 0.0616 0.0616
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0574 0.1814
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0266 0.0271
Onchocerca volvulus 0.0023 0.0066 0.0066
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0231 0.0682
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0269 0.0794
Loa Loa (eye worm) hypothetical protein 0.0075 0.0574 0.0574
Plasmodium vivax phosphoglycerate kinase, putative 0.0345 0.3167 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0066 0.0196
Brugia malayi hypothetical protein 0.0023 0.0074 0.0074
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0574 0.1697
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0204 0.0574
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0228 0.0674
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0077 0.0589 0.1686
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0199 0.1767 0.3908
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0241 0.0712
Echinococcus granulosus L aminoadipate semialdehyde 0.0089 0.0703 0.103
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0052 0.0032
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0189 0.037
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0206 0.0277
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0589 0.1686
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0077 0.0589 0.0589
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0241 0.0761
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0352 0.092
Giardia lamblia Phosphoglycerate kinase 0.0345 0.3167 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0089 0.0703 0.0762
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0052 0.0044
Onchocerca volvulus 0.011 0.0905 0.0905
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0066 0.0096
Loa Loa (eye worm) hypothetical protein 0.0057 0.0402 0.0402
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0254 0.0803
Echinococcus multilocularis lysosomal alpha glucosidase 0.019 0.1676 0.1853
Plasmodium vivax acyl-CoA synthetase, putative 0.0057 0.0402 0.1204
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0241 0.0244
Leishmania major phosphoglycerate kinase B, cytosolic 0.0345 0.3167 0.9357
Brugia malayi RNA, U transporter 1 0.0094 0.0755 0.0755
Trypanosoma brucei phosphoglycerate kinase 0.0345 0.3167 0.9357
Loa Loa (eye worm) runx1 0.0132 0.1122 0.1122
Brugia malayi beta-lactamase family protein 0.0075 0.0574 0.0574
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0027 0.0111 0.0328
Brugia malayi PXA domain containing protein 0.0021 0.0052 0.0052
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0066 0.0196
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0054 0.0365 0.1077
Loa Loa (eye worm) hypothetical protein 0.0021 0.0052 0.0052
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0034 0.0172 0.0167
Loa Loa (eye worm) hypothetical protein 0.031 0.2829 0.2829
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0231 0.0231
Mycobacterium ulcerans phosphoglycerate kinase 0.0345 0.3167 1
Schistosoma mansoni microtubule-associated protein tau 0.0703 0.6617 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0027 0.0107 0.0107
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0231 0.0461
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0066 0.0209
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0024 0.007
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0027 0.0111 0.0098
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0066 0.0096
Loa Loa (eye worm) hypothetical protein 0.0037 0.0206 0.0206
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0499 0.0722
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0148 0.0397
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0228 0.0651
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0254 0.0803
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0052 0.0052
Schistosoma mansoni alpha-glucosidase 0.0163 0.1421 0.212
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0119 0.0352
Chlamydia trachomatis phosphoglycerate kinase 0.0345 0.3167 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0616 0.1772
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0499 0.0722
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0345 0.3167 1
Giardia lamblia DINP protein human, muc B family 0.0041 0.0241 0.0425
Brugia malayi Importin beta-1 subunit 0.0033 0.0168 0.0168
Echinococcus multilocularis transcription factor Dp 1 0.0036 0.0193 0.0189
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0589 0.1741
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.0052 0.0052
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0231 0.0659
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0052 0.0052
Toxoplasma gondii thioredoxin reductase 0.0079 0.0605 0.185
Schistosoma mansoni importin beta-1 0.0033 0.0168 0.0219
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0499 0.0499
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.0616 0.1712
Trypanosoma brucei unspecified product 0.0028 0.0119 0.0352
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0052 0.0044
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.0589 0.186
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0027 0.0111 0.0278
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0027 0.0111 0.0328
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0066 0.0096
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0231 0.0729
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0589 0.1741
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0066 0.0066
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0589 0.1686
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0052 0.0032
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0052 0.0044
Plasmodium vivax acetyl-CoA synthetase, putative 0.0023 0.0066 0.0136
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0616 0.1712
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0241 0.0712
Echinococcus granulosus dna polymerase eta 0.0072 0.0539 0.0782
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0254 0.0803
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0345 0.3167 0.7049
Echinococcus multilocularis peregrin 0.0031 0.0148 0.014
Toxoplasma gondii hypothetical protein 0.0027 0.0113 0.0285
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0231 0.0682
Loa Loa (eye worm) glutaminase 0.0292 0.2656 0.2656
Onchocerca volvulus 0.0026 0.0101 0.0101
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0148 0.0189
Plasmodium vivax importin-beta 2, putative 0.0033 0.0168 0.0458
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0113 0.0078
Loa Loa (eye worm) hypothetical protein 0.0021 0.0052 0.0052
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0482 0.4483 1
Brugia malayi Pre-SET motif family protein 0.0254 0.2291 0.2291
Schistosoma mansoni inositol monophosphatase 0.0039 0.0228 0.031
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0228 0.0721
Onchocerca volvulus Alhambra homolog 0.0031 0.0148 0.0148
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0024 0.007
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0499 0.0722
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0241 0.0329
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0023 0.0066 0.0096
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0024 0.007
Loa Loa (eye worm) glutaminase 2 0.0292 0.2656 0.2656
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0023 0.0066 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0241 0.0712
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0058 0.0409 0.0585
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0241 0.0563
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0052 0.0052
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0027 0.0111 0.0144
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0027 0.0111 0.0133
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0077 0.0589 0.1686
Onchocerca volvulus 0.0023 0.0066 0.0066
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0574 0.1639
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0052 0.0052
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0254 0.2291 0.2291
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0027 0.0111 0.0071
Toxoplasma gondii exonuclease III APE 0.004 0.0231 0.0659
Echinococcus multilocularis dna polymerase eta 0.0072 0.0539 0.0578
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0034 0.0172 0.0226
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0574 0.1639
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0127 0.1067 0.3153
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.0616 0.0898
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0111 0.0328
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0352 0.0368
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0241 0.0329
Brugia malayi hypothetical protein 0.0034 0.0172 0.0172
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.002 0.0042 0.0042
Treponema pallidum NADH oxidase 0.0027 0.0111 0.0071
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0254 0.0803
Mycobacterium tuberculosis Probable oxidoreductase 0.0199 0.1767 0.3908
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0111 0.0328
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0189 0.1672 0.1672
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0241 0.0712
Echinococcus granulosus cpg binding protein 0.0028 0.0122 0.0149
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0241 0.0712
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0345 0.3167 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.005 0.033 0.033
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0254 0.0803
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0231 0.0231
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0024 0.007
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0113 0.0151
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0127 0.1067 0.3153
Plasmodium falciparum importin beta, putative 0.0033 0.0168 0.0458
Toxoplasma gondii propionate-CoA ligase 0.0023 0.0066 0.0136
Echinococcus multilocularis cpg binding protein 0.0028 0.0122 0.011
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0266 0.0367
Mycobacterium tuberculosis Conserved protein 0.0075 0.0574 0.1235
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0066 0.0196
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0589 0.0589
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0345 0.3167 0.9357
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0089 0.0263
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0241 0.0712
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0113 0.0285
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0062 0.0442 0.1397
Trichomonas vaginalis glutathione reductase, putative 0.0027 0.0111 0.0351
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0499 0.0722
Brugia malayi isocitrate dehydrogenase 0.0018 0.0024 0.0024
Loa Loa (eye worm) RNA binding protein 0.0068 0.0499 0.0499
Brugia malayi Inositol-1 0.0039 0.0228 0.0228
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.1672 0.25
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0052 0.0044
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0052 0.0044
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0052 0.0032
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0241 0.0712
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0052 0.0346 0.1023
Brugia malayi beta-lactamase 0.0075 0.0574 0.0574
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0254 0.0803
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0052 0.0052
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0079 0.0605 0.1304
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0066 0.0209
Schistosoma mansoni DNA polymerase eta 0.0072 0.0539 0.0782
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0199 0.1767 0.3908
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0111 0.0328
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0052 0.0044
Loa Loa (eye worm) hypothetical protein 0.0143 0.1229 0.1229
Loa Loa (eye worm) oxidoreductase 0.0023 0.0066 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0206 0.0652
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0052 0.0166
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0354 0.3252 0.3252
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0077 0.0589 0.1268
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0089 0.0208
Loa Loa (eye worm) inositol-1 0.0039 0.0228 0.0228
Entamoeba histolytica phosphoglycerate kinase, putative 0.0345 0.3167 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0206 0.0652
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0052 0.0166
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0616 0.1884
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0241 0.0761
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0206 0.061
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0027 0.0111 0.0196
Echinococcus multilocularis snurportin 1 0.0354 0.3252 0.362
Leishmania major mitochondrial DNA polymerase beta 0.0367 0.3385 1
Toxoplasma gondii ABC1 family protein 0.0075 0.0574 0.1752
Loa Loa (eye worm) hypothetical protein 0.0057 0.0402 0.0402
Brugia malayi beta-lactamase family protein 0.0075 0.0574 0.0574
Loa Loa (eye worm) hypothetical protein 0.0021 0.0052 0.0052
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0204 0.0274
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0054 0.0365 0.0517
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0574 0.1814
Onchocerca volvulus 0.0037 0.0204 0.0204
Entamoeba histolytica hypothetical protein 0.0021 0.0052 0.0166
Schistosoma mansoni cpg binding protein 0.0027 0.0107 0.0127
Echinococcus granulosus expressed protein 0.0412 0.381 0.5743
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0228 0.0674
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0231 0.0461
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0089 0.0147
Brugia malayi hypothetical protein 0.0236 0.2116 0.2116
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0241 0.0712
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0052 0.0044
Brugia malayi glutaminase DH11.1 0.0292 0.2656 0.2656
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.0589 0.1686
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0111 0.0328
Loa Loa (eye worm) hypothetical protein 0.0089 0.0703 0.0703
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.019 0.1676 0.1676
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0054 0.0365 0.0765
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0027 0.0111 0.0133
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0204 0.0202
Loa Loa (eye worm) hypothetical protein 0.0057 0.0402 0.0402
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0206 0.0652
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0052 0.0032
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.1672 0.1848
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0127 0.1067 0.3153
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.002 0.0042 0.0042
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0066 0.0196
Mycobacterium tuberculosis Conserved protein 0.0075 0.0574 0.1235
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.0829 0.1222
Plasmodium falciparum ataxin-2 like protein, putative 0.0023 0.0074 0.0161
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0574 0.0574
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0089 0.0263
Schistosoma mansoni alpha-glucosidase 0.0163 0.1421 0.212
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0241 0.0244
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0052 0.0044
Brugia malayi Glycosyl hydrolases family 31 protein 0.019 0.1676 0.1676
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.0241 0.0487
Schistosoma mansoni hypothetical protein 0.0354 0.3252 0.4896
Plasmodium falciparum ataxin-2 like protein, putative 0.0023 0.0074 0.0161
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0052 0.0044
Echinococcus granulosus muscleblind protein 0.031 0.2829 0.4255
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0236 0.2123 0.2123
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0231 0.0465
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.1672 0.1848
Loa Loa (eye worm) beta-lactamase 0.0075 0.0574 0.0574
Loa Loa (eye worm) hypothetical protein 0.0031 0.0148 0.0148
Echinococcus multilocularis microtubule associated protein 2 0.0703 0.6617 0.7394
Brugia malayi Pre-SET motif family protein 0.0037 0.0204 0.0204
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0206 0.061
Schistosoma mansoni hypothetical protein 0.0034 0.0172 0.0226
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0241 0.0712
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0027 0.0111 0.0328
Schistosoma mansoni inositol monophosphatase 0.0039 0.0228 0.031
Loa Loa (eye worm) hypothetical protein 0.0023 0.0066 0.0066
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0111 0.0328
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0346 0.1023
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0226 0.0307
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0199 0.1767 0.5483
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0574 0.1814
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0052 0.0052
Trypanosoma brucei phosphoglycerate kinase 0.0345 0.3167 0.9357
Trypanosoma brucei phosphoglycerate kinase, putative 0.0127 0.1067 0.3153
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0052 0.0032
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0027 0.0111 0.0328
Onchocerca volvulus 0.0023 0.0066 0.0066
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0052 0.0346 0.1023
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0228 0.0229
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0574 0.0835
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0024 0.0024
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0027 0.0111 0.0144
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0226 0.0226
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0052 0.0032
Trypanosoma brucei unspecified product 0.0041 0.0241 0.0712
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0231 0.0314
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0089 0.0208
Onchocerca volvulus 0.0027 0.0107 0.0107
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0107 0.0339
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0241 0.0712
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0231 0.0682
Echinococcus multilocularis geminin 0.0195 0.1722 0.1905
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0052 0.0044
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.0616 0.1772
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0204 0.0274
Schistosoma mansoni lozenge 0.0132 0.1122 0.1666
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0023 0.0066 0.0136
Brugia malayi Phosphoglycerate kinase 0.0345 0.3167 0.3167
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0168 0.0458
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.0589 0.186
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0052 0.0044
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0027 0.0111 0.0328
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0127 0.1067 0.3153
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0077 0.0589 0.1686
Brugia malayi PHD-finger family protein 0.0031 0.0148 0.0148
Brugia malayi Bromodomain containing protein 0.0031 0.0148 0.0148
Leishmania major phosphoglycerate kinase C, glycosomal 0.0345 0.3167 0.9357
Brugia malayi RNA binding protein 0.0068 0.0499 0.0499
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0231 0.0682
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0574 0.1697
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0062 0.0442 0.0442
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0023 0.0066 0.0096
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0254 0.0751
Leishmania major DNA polymerase eta, putative 0.0072 0.0539 0.1593
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0254 0.0803
Brugia malayi ImpB/MucB/SamB family protein 0.0072 0.0539 0.0539
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0027 0.0111 0.0278
Trypanosoma brucei phosphoglycerate kinase 0.0127 0.1067 0.3153
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0574 0.1814
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0945 0.894 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0226 0.0307
Echinococcus multilocularis thioredoxin glutathione reductase 0.008 0.0615 0.0664
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0372 0.0781
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0499 0.0499
Leishmania major DNA polymerase eta, putative 0.0044 0.0269 0.0794
Loa Loa (eye worm) hypothetical protein 0.0077 0.0589 0.0589
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0054 0.0365 0.0962
Echinococcus granulosus dna polymerase kappa 0.0041 0.0241 0.0329
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0052 0.0044
Trypanosoma cruzi DNA polymerase eta, putative 0.0072 0.0539 0.1593
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0365 0.0365
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0052 0.0166
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0127 0.1067 0.3153
Onchocerca volvulus Huntingtin homolog 0.0143 0.1229 0.1229
Entamoeba histolytica hypothetical protein 0.0021 0.0052 0.0166
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0345 0.3167 1
Echinococcus granulosus importin subunit beta 1 0.0033 0.0168 0.0219
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0206 0.0206
Trypanosoma cruzi trypanothione reductase, putative 0.0079 0.0605 0.1788
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0206 0.061
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0052 0.0166
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0204 0.0202
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0179 0.1574 0.3476
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0052 0.0166
Schistosoma mansoni hypothetical protein 0.0195 0.1722 0.2576
Echinococcus granulosus neuropeptide receptor A26 0.054 0.5049 0.7622
Loa Loa (eye worm) hypothetical protein 0.0075 0.0574 0.0574
Echinococcus multilocularis muscleblind protein 1 0.031 0.2829 0.3146
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0367 0.3385 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0589 0.1686
Leishmania major trypanothione reductase 0.0079 0.0605 0.1788
Echinococcus granulosus geminin 0.0195 0.1722 0.2576
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0206 0.0277
Loa Loa (eye worm) hypothetical protein 0.0021 0.0052 0.0052
Echinococcus multilocularis expressed protein 0.0412 0.381 0.4247
Brugia malayi glutathione reductase 0.0079 0.0605 0.0605
Schistosoma mansoni cpg binding protein 0.0028 0.0122 0.0149
Treponema pallidum phosphoglycerate kinase 0.0345 0.3167 1
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0148 0.0148
Schistosoma mansoni hypothetical protein 0.0031 0.0148 0.0189
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0589 0.1741
Giardia lamblia PHD finger protein 15 0.0031 0.0148 0.0122
Trypanosoma brucei glucosidase, putative 0.0042 0.0254 0.0751
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0148 0.0397
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.0589 0.1686
Echinococcus granulosus microtubule associated protein 2 0.0703 0.6617 1
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0023 0.0066 0.0209
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0228 0.031
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0179 0.1574 0.3476
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0054 0.0365 0.0962
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0077 0.0589 0.1268
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0027 0.0111 0.0144
Schistosoma mansoni ap endonuclease 0.004 0.0231 0.0314
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.0052 0.0052
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0089 0.0703 0.0703
Echinococcus granulosus lysosomal alpha glucosidase 0.019 0.1676 0.2505
Brugia malayi follicle stimulating hormone receptor 0.0236 0.2123 0.2123
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0062 0.0442 0.0442
Echinococcus multilocularis lysosomal alpha glucosidase 0.019 0.1676 0.1853
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0066 0.0066
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0027 0.0111 0.0328
Mycobacterium ulcerans beta-lactamase 0.0075 0.0574 0.1639
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0228 0.0452
Trypanosoma cruzi trypanothione reductase, putative 0.0027 0.0111 0.0328
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0204 0.0274
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0066 0.0066
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0499 0.0534
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0228 0.0674
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0254 0.0254
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0241 0.0712
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0254 0.0254
Brugia malayi jmjC domain containing protein 0.0102 0.0829 0.0829
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.0074 0.022
Toxoplasma gondii LsmAD domain-containing protein 0.0023 0.0074 0.0161
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0574 0.1235
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0075 0.0574 0.0574
Schistosoma mansoni survival motor neuron protein 0.0048 0.0311 0.0436
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.1672 0.25
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0206 0.0312
Brugia malayi jmjC domain containing protein 0.0039 0.0226 0.0226
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0179 0.1574 0.3476
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0062 0.0442 0.1307
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0345 0.3167 0.9357
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0241 0.0712
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.2116 0.2347
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0467 0.0467
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.1672 0.25
Loa Loa (eye worm) hypothetical protein 0.0021 0.0052 0.0052
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0574 0.1814
Loa Loa (eye worm) glutathione reductase 0.0079 0.0605 0.0605
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0189 0.1672 0.1672
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0119 0.0352
Mycobacterium tuberculosis Probable dehydrogenase 0.0179 0.1574 0.3476
Loa Loa (eye worm) hypothetical protein 0.0053 0.0362 0.0362
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0027 0.0111 0.0071
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0228 0.0721
Leishmania major hypothetical protein, conserved 0.0075 0.0574 0.1697
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0066 0.0196
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0254 0.0803
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.2116 0.3174
Trypanosoma brucei unspecified product 0.0028 0.0119 0.0352
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0057 0.0402 0.1017
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0231 0.0392
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0027 0.0111 0.0328
Loa Loa (eye worm) hypothetical protein 0.0021 0.0052 0.0052
Mycobacterium ulcerans hypothetical protein 0.0194 0.1711 0.5305
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.1672 0.25
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0228 0.0721
Plasmodium vivax SET domain protein, putative 0.0037 0.0204 0.0574
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0057 0.0402 0.0848
Mycobacterium tuberculosis Conserved protein 0.0075 0.0574 0.1235
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0367 0.3385 1
Schistosoma mansoni transcription factor LCR-F1 0.0034 0.0172 0.0226
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0174 0.1522 0.4498
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0021 0.0052 0.0166
Loa Loa (eye worm) hypothetical protein 0.0023 0.0066 0.0066
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.0616 0.1884
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0241 0.0241
Echinococcus granulosus peregrin 0.0031 0.0148 0.0189
Echinococcus multilocularis muscleblind protein 0.031 0.2829 0.3146
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0616 0.1884
Plasmodium falciparum glutathione reductase 0.0079 0.0605 0.185
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0054 0.0365 0.0382
Mycobacterium leprae Probable lipase LipE 0.0075 0.0574 0.1639
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0052 0.0044
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0206 0.0277
Echinococcus multilocularis neuropeptide receptor A26 0.054 0.5049 0.5636
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0062 0.0442 0.1307
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0066 0.0196
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0066 0.0066
Plasmodium falciparum glutathione reductase 0.0027 0.0111 0.0278
Loa Loa (eye worm) hypothetical protein 0.0077 0.0589 0.0589
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0027 0.0111 0.0328
Schistosoma mansoni hypothetical protein 0.0195 0.1722 0.2576
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0231 0.0659
Trypanosoma brucei PAB1-binding protein , putative 0.0023 0.0074 0.022
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0574 0.1235
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0089 0.0208
Plasmodium falciparum thioredoxin reductase 0.0079 0.0605 0.185
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.1672 0.25
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0052 0.0044
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0254 0.0734
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0063 0.0455 0.1344
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0127 0.1067 0.3153
Loa Loa (eye worm) hypothetical protein 0.031 0.2829 0.2829
Mycobacterium ulcerans hypothetical protein 0.0075 0.0574 0.1639
Entamoeba histolytica hypothetical protein 0.0034 0.0172 0.0544
Leishmania major hypothetical protein, conserved 0.0023 0.0074 0.022
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0574 0.1235
Schistosoma mansoni phosphoglycerate kinase 0.0345 0.3167 0.4768
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0052 0.0044
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0052 0.0052
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0241 0.0761
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0052 0.0052

Activities

Activity type Activity value Assay description Source Reference
MIC90 (functional) = 0.39 ug ml-1 Antitubercular activity against Mycobacterium tuberculosis H37Rv by broth dilution method ChEMBL. 19524330

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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