Detailed information for compound 1068189

Basic information

Technical information
  • TDR Targets ID: 1068189
  • Name: 4-(2,5-dioxopyrrolidin-1-yl)-N-ethyl-N-[2-oxo -2-[[2-(trifluoromethyl)phenyl]amino]ethyl]be nzamide
  • MW: 447.407 | Formula: C22H20F3N3O4
  • H donors: 1 H acceptors: 4 LogP: 2.32 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)c1ccc(cc1)N1C(=O)CCC1=O)CC(=O)Nc1ccccc1C(F)(F)F
  • InChi: 1S/C22H20F3N3O4/c1-2-27(13-18(29)26-17-6-4-3-5-16(17)22(23,24)25)21(32)14-7-9-15(10-8-14)28-19(30)11-12-20(28)31/h3-10H,2,11-13H2,1H3,(H,26,29)
  • InChiKey: DZMQMZOETXEIMN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(2,5-dioxo-1-pyrrolidinyl)-N-ethyl-N-[2-oxo-2-[[2-(trifluoromethyl)phenyl]amino]ethyl]benzamide
  • N-ethyl-N-[2-keto-2-[[2-(trifluoromethyl)phenyl]amino]ethyl]-4-succinimido-benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens v-ets avian erythroblastosis virus E26 oncogene homolog Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K09435 transcriptional regulator ERG, putative Get druggable targets OG5_131947 All targets in OG5_131947
Schistosoma mansoni ets-related Get druggable targets OG5_131947 All targets in OG5_131947
Loa Loa (eye worm) fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi Fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0012 0.0011 0.0014
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0122 0.1841 0.2418
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0441 0.1246
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.1008 0.2853
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0114 0.112
Brugia malayi beta-lactamase 0.0072 0.1008 0.1465
Loa Loa (eye worm) hypothetical protein 0.0038 0.0441 0.044
Brugia malayi Patched family protein 0.0012 0.0011 0.0014
Brugia malayi Importin beta-1 subunit 0.0057 0.0758 0.1102
Schistosoma mansoni cpg binding protein 0.003 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Loa Loa (eye worm) patched family protein 0.0012 0.0011 0.001
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.0016 0.0016
Echinococcus granulosus dna polymerase kappa 0.0038 0.0441 0.0441
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0242 0.0682
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0205 0.2026
Trypanosoma brucei DNA polymerase eta, putative 0.0038 0.0441 0.1246
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Echinococcus granulosus cpg binding protein 0.0031 0.0331 0.0331
Brugia malayi protein C24B5.3 0.0012 0.0011 0.0014
Brugia malayi Pre-SET motif family protein 0.0061 0.0826 0.1201
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.09 0.09
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0113 0.0102
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0331 0.0331
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0414 0.0414
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Mycobacterium tuberculosis Conserved protein 0.0072 0.1008 0.1301
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0441 0.1246
Onchocerca volvulus Alhambra homolog 0.0029 0.0285 0.0349
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Echinococcus multilocularis ETS transcription factor Elf 5 0.0013 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0414 0.0414
Brugia malayi Patched family protein 0.0012 0.0011 0.0014
Echinococcus multilocularis protein C ets 2 0.0013 0.0016 0.0016
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0414 0.0414
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0026 0.0232 0.2298
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1471 0.147
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0392 0.1748
Toxoplasma gondii cytochrome p450 superfamily protein 0.0014 0.0037 0.0357
Echinococcus multilocularis neuropeptide s receptor 0.0521 0.8539 0.8539
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Schistosoma mansoni ran 0.0042 0.0506 0.0506
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0135 0.2068 0.2723
Brugia malayi glutathione reductase 0.0053 0.0697 0.1012
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0205 0.2026
Schistosoma mansoni inositol monophosphatase 0.0039 0.0461 0.0461
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0331 0.0331
Schistosoma mansoni hypothetical protein 0.0013 0.0016 0.0016
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0441 0.1246
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.138 0.138
Mycobacterium tuberculosis Conserved protein 0.0072 0.1008 0.1301
Toxoplasma gondii patched family protein 0.0012 0.0011 0.0099
Schistosoma mansoni Smad4 0.0016 0.008 0.008
Mycobacterium ulcerans hypothetical protein 0.0026 0.0232 0.2298
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0441 0.1246
Trypanosoma brucei trypanothione reductase 0.0053 0.0697 0.1971
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0103 0.1017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0551 0.0551
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0551 0.0551
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0207 0.3282 0.3282
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0506 0.0505
Brugia malayi MH2 domain containing protein 0.0242 0.3864 0.5623
Loa Loa (eye worm) hypothetical protein 0.0018 0.0103 0.0102
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0242 0.0682
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0015
Mycobacterium ulcerans lipase LipD 0.0072 0.1008 1
Plasmodium falciparum importin beta, putative 0.0057 0.0758 1
Echinococcus multilocularis ets variant gene 4 0.0013 0.0016 0.0016
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0461 0.0461
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0013 0.0016 0.0015
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1471 0.214
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0026 0.0232 0.2298
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0114 0.0319
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.008 0.008
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0014 0.0037 0.0357
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0014 0.0037 0.0357
Loa Loa (eye worm) hypothetical protein 0.0099 0.1471 0.147
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0103 0.1351
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0016 0.0016
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0205 0.0827
Echinococcus multilocularis peregrin 0.0029 0.0285 0.0285
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.1008 0.1301
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0826 0.0826
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0441 0.1246
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0113 0.1476
Loa Loa (eye worm) patched family protein 0.0012 0.0011 0.001
Echinococcus granulosus citrate lyase subunit beta protein 0.0026 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.0057 0.0758 0.0757
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0758 0.0758
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0285 0.2817
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.1008 0.1008
Echinococcus multilocularis neuropeptide receptor A26 0.0521 0.8539 0.8539
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0014 0.0037 0.0357
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0026 0.0232 0.0155
Schistosoma mansoni hypothetical protein 0.0031 0.0331 0.0331
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0113 0.111
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0014 0.0037 0.0102
Echinococcus multilocularis GPCR, family 2 0.0031 0.0331 0.0331
Leishmania major importin beta-1 subunit, putative 0.0046 0.0578 0.1635
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0114 0.0114
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0826 0.0826
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0461 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0135 0.2068 0.2723
Mycobacterium tuberculosis Conserved protein 0.0026 0.0232 0.0262
Brugia malayi beta-lactamase family protein 0.0072 0.1008 0.1465
Schistosoma mansoni hypothetical protein 0.0084 0.122 0.122
Trypanosoma brucei unspecified product 0.0038 0.0441 0.1246
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0441 0.0441
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0414 0.0414
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0441 0.0424
Mycobacterium tuberculosis Probable dehydrogenase 0.0122 0.1841 0.2418
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.1008 1
Brugia malayi Smad1 0.0016 0.008 0.0115
Loa Loa (eye worm) hypothetical protein 0.0018 0.0103 0.0102
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0414 0.117
Brugia malayi Patched family protein 0.0012 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Schistosoma mansoni hypothetical protein 0.0424 0.6919 0.6919
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0826 0.0826
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0114 0.0103
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0285 0.0285
Echinococcus multilocularis expressed conserved protein 0.0192 0.3021 0.3021
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0113 0.111
Plasmodium falciparum lipid/sterol:H+ symporter 0.0012 0.0011 0.0131
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0331 0.033
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0242 0.0682
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0205 0.2026
Loa Loa (eye worm) fli-1 protein 0.0265 0.4255 0.4255
Brugia malayi cytochrome P450 0.0014 0.0037 0.0052
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0441 0.0441
Echinococcus multilocularis dna polymerase eta 0.0038 0.0441 0.0441
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0441 0.0441
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0758 0.2147
Echinococcus granulosus peregrin 0.0029 0.0285 0.0285
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0461 0.457
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0551 0.08
Schistosoma mansoni elf1 0.0013 0.0016 0.0016
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.008 0.0079
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0506 0.667
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0826 0.0826
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0114 0.1488
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0441 0.1246
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0331 0.0331
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0205 0.0297
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0113 0.111
Brugia malayi jmjC domain containing protein 0.0094 0.138 0.2007
Loa Loa (eye worm) inositol-1 0.0039 0.0461 0.046
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0068 0.0943 0.0943
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0113 0.0113
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.1008 0.1301
Loa Loa (eye worm) hypothetical protein 0.0018 0.0103 0.0102
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.008 0.008
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0205 0.0578
Giardia lamblia DINP protein human, muc B family 0.0038 0.0441 0.8699
Echinococcus multilocularis ETS transcription factor Elf 1 0.0013 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Brugia malayi hypothetical protein 0.0309 0.4992 0.7264
Loa Loa (eye worm) hypothetical protein 0.0068 0.0943 0.0942
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0015
Echinococcus multilocularis ewsr:fli fusion protein type 0.0013 0.0016 0.0016
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.008 0.008
Toxoplasma gondii patched family protein 0.0012 0.0011 0.0099
Echinococcus multilocularis Niemann Pick C1 protein 0.0292 0.4699 0.4699
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0506 0.1432
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0182 0.0181
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0087 0.0067
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0114 0.0164
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0113 0.0317
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0461 0.457
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0414 0.0389
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0441 0.1246
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0113 0.0317
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0697 0.0884
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0014 0.0037 0.0357
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0331 0.048
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0113 0.0317
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0037 0.0037
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0014 0.0037 0.0357
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0414 0.117
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0088 0.1273 0.1272
Echinococcus multilocularis cpg binding protein 0.0031 0.0331 0.0331
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0014 0.0037 0.0357
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0551 0.055
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0113 0.0163
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0551 0.0551
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0578 0.1635
Loa Loa (eye worm) glutathione reductase 0.0053 0.0697 0.0696
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0113 0.0317
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0113 1
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0943 0.1371
Loa Loa (eye worm) hypothetical protein 0.0049 0.0629 0.0627
Echinococcus multilocularis protein patched 0.0088 0.1273 0.1273
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0205 0.0578
Mycobacterium ulcerans beta-lactamase 0.0072 0.1008 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0441 0.1246
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0204 0.3229 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.1008 0.1008
Loa Loa (eye worm) hypothetical protein 0.0204 0.3229 0.3228
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0414 0.0414
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0243 0.0685
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0285 0.2817
Loa Loa (eye worm) hypothetical protein 0.0075 0.1057 0.1056
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0414 0.0389
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.1008 0.1301
Brugia malayi Patched family protein 0.0012 0.0011 0.0014
Onchocerca volvulus 0.0072 0.1008 0.1272
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0242 0.3178
Echinococcus granulosus GPCR family 2 0.0031 0.0331 0.0331
Trypanosoma brucei hypothetical protein, conserved 0.0222 0.3529 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0303 0.0302
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.1008 0.1157
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.1008 0.1301
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0113 0.111
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0414 0.117
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0113 0.0317
Brugia malayi Patched family protein 0.0012 0.0011 0.0014
Echinococcus granulosus importin subunit beta 1 0.0057 0.0758 0.0758
Echinococcus granulosus dna polymerase eta 0.0038 0.0441 0.0441
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0182 0.0512
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0461 0.1304
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0114 0.0001
Leishmania major hypothetical protein, conserved 0.0222 0.3529 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0506 0.1432
Brugia malayi Cytochrome P450 family protein 0.0023 0.0182 0.0263
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0331 0.048
Plasmodium vivax patched family protein, putative 0.0012 0.0011 0.0099
Schistosoma mansoni cpg binding protein 0.0031 0.0331 0.0331
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0506 0.1432
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0461 0.1304
Loa Loa (eye worm) hypothetical protein 0.0061 0.0826 0.0825
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0205 0.2026
Plasmodium vivax SET domain protein, putative 0.0061 0.0826 0.82
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0441 0.0424
Brugia malayi RNA, U transporter 1 0.0162 0.2519 0.3666
Brugia malayi Niemann-Pick C1 protein precursor 0.0204 0.3229 0.4698
Plasmodium falciparum phd finger protein, putative 0.0029 0.0285 0.3744
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0014 0.0037 0.0357
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.1008 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0114 0.0027
Brugia malayi MH2 domain containing protein 0.0016 0.008 0.0115
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0103 0.1017
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0441 0.044
Brugia malayi Cytochrome P450 family protein 0.0052 0.0667 0.0969
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0014 0.0037 0.0357
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0826 0.82
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0441 0.0541
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0205 0.2026
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0697 0.1971
Brugia malayi hypothetical protein 0.0017 0.0086 0.0124
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0113 0.0113
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0113 0.0317
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0697 0.691
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0205 0.2026
Trypanosoma cruzi hypothetical protein, conserved 0.0222 0.3529 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0103 0.0102
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0122 0.1841 0.2418
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0414 0.0413
Brugia malayi Patched family protein 0.0012 0.0011 0.0014
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0031 0.0043
Toxoplasma gondii patched family protein 0.0012 0.0011 0.0099
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0014 0.0037 0.0357
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0014 0.0037 0.0102
Loa Loa (eye worm) hypothetical protein 0.0024 0.0205 0.0204
Schistosoma mansoni hypothetical protein 0.0544 0.892 0.892
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0441 0.1246
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.008 0.008
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0182 0.0512
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0114 0.0319
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.138 0.138
Trichomonas vaginalis set domain proteins, putative 0.048 0.7846 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0014 0.0037 0.0357
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0031 0.0043
Plasmodium falciparum thioredoxin reductase 0.0053 0.0697 0.9183
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0414 0.117
Trypanosoma brucei unspecified product 0.0026 0.0243 0.0685
Toxoplasma gondii hypothetical protein 0.0012 0.0011 0.0099
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0026 0.0232 0.0262
Loa Loa (eye worm) hypothetical protein 0.0107 0.1604 0.1603
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0026 0.0232 0.0656
Brugia malayi hypothetical protein 0.0012 0.0011 0.0014
Leishmania major DNA polymerase eta, putative 0.0038 0.0441 0.1246
Loa Loa (eye worm) hypothetical protein 0.0024 0.0205 0.0204
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0797 0.0796
Loa Loa (eye worm) patched family protein 0.0012 0.0011 0.001
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0578 0.0601
Brugia malayi Patched family protein 0.0012 0.0011 0.0014
Onchocerca volvulus 0.0024 0.0205 0.0248
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0697 0.0697
Brugia malayi Patched family protein 0.0012 0.0011 0.0014
Schistosoma mansoni hypothetical protein 0.0013 0.0016 0.0016
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0014 0.0037 0.0102
Loa Loa (eye worm) ets-domain-containing protein 0.0013 0.0016 0.0015
Schistosoma mansoni smad1 5 8 and 0.0016 0.008 0.008
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1471 0.214
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0087 0.0067
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0014 0.0037 0.0357
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0014 0.0037 0.0357
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0205 0.2026
Echinococcus granulosus Niemann Pick C1 protein 0.0292 0.4699 0.4699
Brugia malayi MH1 domain containing protein 0.0016 0.008 0.0115
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0285 0.2817
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.1008 0.2853
Schistosoma mansoni ets 0.0013 0.0016 0.0016
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0205 0.0293
Loa Loa (eye worm) hypothetical protein 0.0029 0.0285 0.0284
Schistosoma mansoni cpg binding protein 0.0031 0.0331 0.0331
Echinococcus granulosus Niemann Pick C1 protein 0.0204 0.3229 0.3229
Echinococcus multilocularis Smad4 0.0016 0.008 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0243 0.0685
Echinococcus multilocularis citrate lyase subunit beta protein 0.0026 0.0232 0.0232
Echinococcus granulosus expressed conserved protein 0.0192 0.3021 0.3021
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0578 0.0601
Brugia malayi Inositol-1 0.0039 0.0461 0.0669
Toxoplasma gondii patched family protein 0.0012 0.0011 0.0099
Schistosoma mansoni hypothetical protein 0.0031 0.0331 0.0331
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0087 0.0067
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.008 0.0079
Brugia malayi Patched related family protein 4 0.0012 0.0011 0.0014
Echinococcus multilocularis 0.0014 0.0037 0.0037
Onchocerca volvulus 0.0072 0.1008 0.1272
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0787 0.7809
Leishmania major GTP-binding protein, putative 0.0042 0.0506 0.1432
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0113 0.0317
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0205 0.0578
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0441 0.1246
Schistosoma mansoni patched 1 0.0088 0.1273 0.1273
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0013 0.0016 0.0015
Echinococcus granulosus jumonji domain containing protein 0.004 0.0473 0.0473
Brugia malayi hypothetical protein 0.0012 0.0011 0.0014
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0014 0.0037 0.0357
Brugia malayi Ets-domain containing protein 0.0087 0.127 0.1847
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.1008 0.1008
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0285 0.0284
Schistosoma mansoni cytochrome P450 0.0014 0.0037 0.0037
Brugia malayi hypothetical protein 0.0026 0.0242 0.035
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0113 0.2212
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0386 0.0386
Mycobacterium tuberculosis Probable oxidoreductase 0.0135 0.2068 0.2723
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0182 0.0181
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0421 0.6871 0.687
Brugia malayi Thioredoxin reductase 0.0053 0.0697 0.1012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0072 0.1008 0.1007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Toxoplasma gondii exonuclease III APE 0.0019 0.0114 0.112
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0014 0.0037 0.0357
Echinococcus granulosus sterol regulatory element binding protein 0.0088 0.1273 0.1273
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0758 0.2147
Brugia malayi Patched family protein 0.0012 0.0011 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0441 0.1246
Trichomonas vaginalis ran, putative 0.0042 0.0506 0.0509
Echinococcus granulosus protein C ets 2 0.0013 0.0016 0.0016
Onchocerca volvulus 0.0309 0.4992 0.6357
Echinococcus granulosus dnaJ subfamily B 0.0424 0.6919 0.6919
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0113 0.0317
Trypanosoma brucei unspecified product 0.0026 0.0243 0.0685
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0826 0.0826
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0103 0.0089
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0441 0.0441
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0441 0.1246
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0013 0.0016 0.0016
Leishmania major cytochrome p450-like protein 0.0014 0.0037 0.0102
Echinococcus granulosus ewsr:fli fusion protein type 0.0013 0.0016 0.0016
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0026 0.0232 0.0656
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0441 0.1246
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0285 0.0285
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0331 0.0331
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0243 0.0685
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.015 0.0217
Leishmania major DNA polymerase kappa, putative 0.0038 0.0441 0.1246
Loa Loa (eye worm) hypothetical protein 0.0072 0.1008 0.1007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Brugia malayi jmjC domain containing protein 0.0036 0.0414 0.0602
Schistosoma mansoni hypothetical protein 0.0084 0.122 0.122
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0014 0.0037 0.0357
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0072 0.1008 0.1007
Schistosoma mansoni hypothetical protein 0.0014 0.0037 0.0037
Leishmania major trypanothione reductase 0.0053 0.0697 0.1971
Echinococcus multilocularis protein dispatched 1 0.01 0.1481 0.1481
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0461 0.1115
Mycobacterium tuberculosis Conserved protein 0.0072 0.1008 0.1301
Echinococcus granulosus ETS transcription factor Elf 1 0.0013 0.0016 0.0016
Onchocerca volvulus 0.0072 0.1008 0.1272
Brugia malayi Patched family protein 0.0012 0.0011 0.0014
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0461 0.045
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.1008 0.1301
Trichomonas vaginalis esterase, putative 0.0072 0.1008 0.1157
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0414 0.0414
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0113 0.0317
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0113 0.0317
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0506 0.0506
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0414 0.0414
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0113 0.0317
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0414 0.0414
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0551 0.0551
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.1273 0.1501
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0242 0.2392
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0016 0.0016
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0205 0.0293
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0114 0.0113
Onchocerca volvulus 0.048 0.7846 1
Loa Loa (eye worm) D-ets-2 protein 0.0013 0.0016 0.0015
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0014 0.0037 0.0357
Schistosoma mansoni ets-related 0.0265 0.4255 0.4255
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.1008 0.1301
Schistosoma mansoni ran 0.0042 0.0506 0.0506
Brugia malayi Ets-domain containing protein 0.0087 0.127 0.1847
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0392 0.0476
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0114 0.112
Brugia malayi DNA-binding protein D-ETS-3 0.0013 0.0016 0.0022
Echinococcus granulosus ETS domain containing protein Elk 1 0.0013 0.0016 0.0016
Brugia malayi Cytochrome P450 family protein 0.0023 0.0182 0.0263
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0014 0.0037 0.0357
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0026 0.0232 0.0656
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0037 0.0102
Leishmania major cytochrome p450-like protein 0.0023 0.0182 0.0512
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0114 0.0319
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0441 0.4366
Schistosoma mansoni hypothetical protein 0.0031 0.0331 0.0331
Brugia malayi Patched family protein 0.0012 0.0011 0.0014
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0122 0.1841 0.2418
Echinococcus multilocularis sterol regulatory element binding protein 0.0088 0.1273 0.1273
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0205 0.0297
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0309 0.4992 0.4991
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0026 0.0232 0.2298
Loa Loa (eye worm) hypothetical protein 0.0026 0.0242 0.0241
Schistosoma mansoni hypothetical protein 0.0084 0.122 0.122
Brugia malayi Cytochrome P450 family protein 0.0014 0.0037 0.0052
Brugia malayi Myosin head containing protein 0.0012 0.0011 0.0014
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0182 0.0512
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0113 0.0317
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0242 0.3178
Leishmania major cytochrome p450-like protein 0.0014 0.0037 0.0102
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0114 0.0114
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0113 0.0317
Schistosoma mansoni hypothetical protein 0.0544 0.892 0.892
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.1008 0.1157
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0506 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.008 0.008
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0414 0.0414
Schistosoma mansoni hypothetical protein 0.0031 0.0331 0.0331
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0551 0.0551
Loa Loa (eye worm) hypothetical protein 0.0036 0.0414 0.0413
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0441 0.1246
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0826 0.0826
Schistosoma mansoni ap endonuclease 0.0019 0.0114 0.0114
Schistosoma mansoni ets-related 0.0013 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0029 0.0285 0.0285
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0441 0.1246
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0506 0.502
Echinococcus granulosus geminin 0.0544 0.892 0.892
Mycobacterium leprae conserved hypothetical protein 0.0072 0.1008 0.4778
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0441 0.064
Onchocerca volvulus 0.003 0.0303 0.0373
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0222 0.3529 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0087 0.0067
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0113 0.0317
Plasmodium vivax hypothetical protein, conserved 0.0072 0.1008 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.1008 0.1301
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0414 0.0963
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0441 0.1246
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Mycobacterium ulcerans hypothetical protein 0.0026 0.0232 0.2298
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Mycobacterium ulcerans hypothetical protein 0.0072 0.1008 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0113 0.111
Onchocerca volvulus 0.0061 0.0826 0.1041
Mycobacterium ulcerans hypothetical protein 0.0024 0.0205 0.2026
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.127 0.127
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0205 0.0225
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0461 0.1304
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0441 0.1246
Echinococcus granulosus Smad4 0.0016 0.008 0.008
Echinococcus multilocularis smad 0.0016 0.008 0.008
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0441 0.0441
Loa Loa (eye worm) hypothetical protein 0.0024 0.0205 0.0204
Loa Loa (eye worm) transcription factor SMAD2 0.0242 0.3864 0.3863
Entamoeba histolytica hypothetical protein 0.0046 0.0578 0.149
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.0016 0.0016
Leishmania major hypothetical protein, conserved 0.0072 0.1008 0.2853
Plasmodium falciparum thioredoxin reductase 0.0018 0.0113 0.1476
Echinococcus multilocularis Niemann Pick C1 protein 0.0204 0.3229 0.3229
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0667 0.0666
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0182 0.0181
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0414 0.817
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0578 0.0601
Loa Loa (eye worm) cytochrome P450 0.0014 0.0037 0.0036
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.1008 0.1157
Brugia malayi Patched protein homolog 1 0.0012 0.0011 0.0014
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0182 0.1794
Schistosoma mansoni smad1 5 8 and 0.0016 0.008 0.008
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0285 0.0285
Echinococcus multilocularis geminin 0.0544 0.892 0.892
Plasmodium vivax glutathione reductase, putative 0.0053 0.0697 0.691
Schistosoma mansoni smad 0.0016 0.008 0.008
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0697 0.0697
Echinococcus granulosus smad 0.0016 0.008 0.008
Schistosoma mansoni inositol monophosphatase 0.0039 0.0461 0.0461
Schistosoma mansoni ap endonuclease 0.0019 0.0114 0.0114
Brugia malayi transcription factor E74 isoform 0.0013 0.0016 0.0022
Brugia malayi Patched family protein 0.0012 0.0011 0.0014
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0441 0.064
Schistosoma mansoni jumonji domain containing protein 0.0075 0.1056 0.1056
Loa Loa (eye worm) hypothetical protein 0.0088 0.1273 0.1272
Loa Loa (eye worm) beta-lactamase 0.0072 0.1008 0.1007
Mycobacterium leprae Probable lipase LipE 0.0072 0.1008 0.4778
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0072 0.1008 0.1007
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0113 0.1476
Loa Loa (eye worm) patched family protein 0.0012 0.0011 0.001
Plasmodium falciparum glutathione reductase 0.0018 0.0113 0.1476
Plasmodium falciparum glutathione reductase 0.0053 0.0697 0.9183
Brugia malayi MH1 domain containing protein 0.0016 0.008 0.0115
Brugia malayi MH2 domain containing protein 0.0016 0.008 0.0115
Brugia malayi Fli-1 protein 0.0265 0.4255 0.6193
Schistosoma mansoni importin beta-1 0.0057 0.0758 0.0758
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0113 0.0317
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0459 0.7497 1
Toxoplasma gondii thioredoxin reductase 0.0053 0.0697 0.691
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.127 0.1269
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0551 0.0551
Echinococcus multilocularis dnaJ subfamily B 0.0424 0.6919 0.6919
Mycobacterium tuberculosis Probable reductase 0.0122 0.1841 0.2418
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.127 0.127
Echinococcus granulosus neuropeptide s receptor 0.0521 0.8539 0.8539
Entamoeba histolytica Ran family GTPase 0.0042 0.0506 0.126
Brugia malayi Patched family protein 0.0012 0.0011 0.0014
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0014 0.0037 0.0357
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0114 0.0001
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0461 0.1304
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.1008 0.1465
Loa Loa (eye worm) Smad1 0.0016 0.008 0.0079
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0414 0.0389
Loa Loa (eye worm) hypothetical protein 0.0072 0.1008 0.1007
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0758 0.7525
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0506 0.502
Schistosoma mansoni hypothetical protein 0.0084 0.122 0.122
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0013 0.0016 0.0016
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0205 0.0293
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0414 0.0414
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0014 0.0037 0.0357
Giardia lamblia PHD finger protein 15 0.0029 0.0285 0.5613
Echinococcus granulosus Protein patched homolog 1 0.0088 0.1273 0.1273
Brugia malayi protein C24B5.3 0.0012 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Toxoplasma gondii ABC1 family protein 0.0072 0.1008 1
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0242 0.2392
Brugia malayi PHD-finger family protein 0.0029 0.0285 0.0413
Brugia malayi CXXC zinc finger family protein 0.003 0.0303 0.0439
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0114 0.0319
Loa Loa (eye worm) hypothetical protein 0.0018 0.0103 0.0102
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0441 0.1246
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0014 0.0037 0.0357
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0441 0.1049
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.1008 0.2853
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0135 0.2068 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0205 0.0297
Brugia malayi CHE-14 protein 0.0088 0.1273 0.1852
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.1008 0.1157
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0441 0.4366
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0122 0.0122
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0114 1
Brugia malayi Patched family protein 0.0012 0.0011 0.0014
Schistosoma mansoni DNA polymerase eta 0.0038 0.0441 0.0441
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.1008 0.1008
Loa Loa (eye worm) hypothetical protein 0.0031 0.0331 0.033
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0461 0.0461
Brugia malayi Bromodomain containing protein 0.0029 0.0285 0.0413
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Brugia malayi beta-lactamase family protein 0.0072 0.1008 0.1465
Brugia malayi Ets-domain containing protein 0.0013 0.0016 0.0022
Plasmodium vivax importin-beta 2, putative 0.0057 0.0758 0.7525
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0461 0.045
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0205 0.0827
Schistosoma mansoni gabp alpha 0.0087 0.127 0.127
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0037 0.0102
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0551 0.0551
Echinococcus granulosus ETS transcription factor Elf 5 0.0013 0.0016 0.0016
Leishmania major hypothetical protein, conserved 0.0026 0.0242 0.0682
Loa Loa (eye worm) MH2 domain-containing protein 0.0242 0.3864 0.3863
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0461 0.045
Loa Loa (eye worm) patched family protein 0.0012 0.0011 0.001
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0506 0.0506
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0113 0.111
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0441 0.1246
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0122 0.1841 0.8881
Loa Loa (eye worm) hypothetical protein 0.0072 0.1008 0.1007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0205 0.0225
Schistosoma mansoni smad1 5 8 and 0.0016 0.008 0.008
Brugia malayi Patched related family protein 10 0.0012 0.0011 0.0014
Brugia malayi Patched family protein 0.0012 0.0011 0.0014
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0826 0.0826
Brugia malayi Pre-SET motif family protein 0.0421 0.6871 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0113 0.0317
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.1008 0.1007
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0473 0.0473
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0114 0.2231
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.1008 0.1157
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0113 0.111
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0414 0.0414
Brugia malayi Patched related family protein 12 0.0012 0.0011 0.0014
Brugia malayi hypothetical protein 0.0012 0.0011 0.0014
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.0441 0.0541
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0113 0.0317
Echinococcus granulosus neuropeptide receptor A26 0.0521 0.8539 0.8539
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0506 0.0735
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0697 0.0696
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0414 0.0601
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0122 0.1841 0.2418
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0778 0.0778

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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