Detailed information for compound 1068266

Basic information

Technical information
  • TDR Targets ID: 1068266
  • Name: 2-[1-[(4-methylphenyl)methyl]-4-[(4-pyrimidin -2-yloxyphenyl)methyl]piperazin-2-yl]ethanol
  • MW: 418.531 | Formula: C25H30N4O2
  • H donors: 1 H acceptors: 3 LogP: 3.31 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCC1CN(CCN1Cc1ccc(cc1)C)Cc1ccc(cc1)Oc1ncccn1
  • InChi: 1S/C25H30N4O2/c1-20-3-5-22(6-4-20)18-29-15-14-28(19-23(29)11-16-30)17-21-7-9-24(10-8-21)31-25-26-12-2-13-27-25/h2-10,12-13,23,30H,11,14-19H2,1H3
  • InChiKey: MEZUOHRSBTYQEF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[1-[(4-methylphenyl)methyl]-4-[[4-(2-pyrimidinyloxy)phenyl]methyl]-2-piperazinyl]ethanol
  • 2-[1-(4-methylbenzyl)-4-(4-pyrimidin-2-yloxybenzyl)piperazin-2-yl]ethanol
  • 2-{1-(4-methylbenzyl)-4-[4-(pyrimidin-2-yloxy)benzyl]piperazin-2-yl}ethanol
  • MLS000732138
  • SMR000316430

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei PAB1-binding protein , putative 0.0205 0.0178 0.295
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0059 0.004 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0084 0.0713
Echinococcus granulosus histone acetyltransferase KAT2B 0.028 0.0249 0.0248
Echinococcus granulosus Protein patched homolog 1 0.0256 0.0226 0.0225
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0063 0.0043 0.0042
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0106 0.0084 0.0083
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0014 0.0221
Trypanosoma brucei chrX additional, unordered contigs 0.0024 0.0006 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0047 0.0389
Onchocerca volvulus 0.0063 0.0043 0.0357
Trypanosoma brucei unspecified product 0.0054 0.0034 0.0531
Brugia malayi hypothetical protein 0.0023 0.0005 0.0036
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0463 0.0422 0.3758
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0175 0.0149 0.0148
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0002 0.0013
Entamoeba histolytica heat shock transcription factor, putative 0.0097 0.0075 0.1345
Trichomonas vaginalis PIKK family atypical protein kinase 0.0212 0.0184 0.1584
Entamoeba histolytica protein kinase rad3, putative 0.006 0.004 0.0704
Schistosoma mansoni neuropeptide receptor 0.0023 0.0005 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0115 0.0115
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0017 0.0016
Echinococcus multilocularis survival motor neuron protein 1 0.0979 0.0911 0.091
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0014 0.0191
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.002 0.0003 0.0019
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0003 0.0003
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.002 0.0003 0.0009
Echinococcus multilocularis sex peptide receptor 0.0023 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.007 0.005 0.044
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Mycobacterium tuberculosis Conserved hypothetical protein 0.0078 0.0057 0.0085
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0005 0.0005
Schistosoma mansoni smad1 5 8 and 0.0082 0.0061 0.0061
Echinococcus multilocularis orexin receptor type 2 0.0023 0.0005 0.0004
Onchocerca volvulus Protein patched homolog 0.0036 0.0018 0.0141
Schistosoma mansoni ferritin 0.0069 0.0048 0.0048
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.0006 0.006
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0037 0.0019 0.0158
Brugia malayi Pre-SET motif family protein 0.1088 0.1014 0.9029
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0133 0.0109 0.0962
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0017 0.0131
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0028 0.0242
Schistosoma mansoni nuclear hormone receptor 0.0063 0.0043 0.0042
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0106 0.0084 0.1369
Trypanosoma brucei hypothetical protein, conserved 0.0186 0.0159 0.2637
Loa Loa (eye worm) hypothetical protein 0.0063 0.0043 0.0377
Onchocerca volvulus 0.0158 0.0133 0.1142
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0042 0.0369
Brugia malayi latrophilin 2 splice variant baaae 0.0661 0.0609 0.5423
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0063 0.0043 0.0377
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0059 0.004 0.0522
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0038 0.0594
Entamoeba histolytica deoxycytidyl transferase, putative 0.0078 0.0057 0.1016
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0005 0.0004
Echinococcus multilocularis smad 0.0082 0.0061 0.006
Schistosoma mansoni hypothetical protein 0.0023 0.0005 0.0005
Brugia malayi nuclear hormone receptor family member nhr-6 0.0063 0.0043 0.0371
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0005 0.0004
Brugia malayi Pre-SET motif family protein 0.0158 0.0133 0.118
Schistosoma mansoni hypothetical protein 0.0023 0.0005 0.0005
Onchocerca volvulus 0.0023 0.0005 0.0031
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0133 0.0109 0.0108
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Trypanosoma brucei trypanothione reductase 0.0647 0.0596 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.164 0.1536 0.2332
Brugia malayi hypothetical protein 0.0036 0.0018 0.0149
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0063 0.0043 0.0042
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0222 0.0194 0.2425
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0023 0.0005 0.0042
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0042 0.0375
Onchocerca volvulus 0.0023 0.0005 0.0031
Loa Loa (eye worm) melatonin receptor type 1A 0.0023 0.0005 0.0042
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0005 0.0004
Echinococcus granulosus L aminoadipate semialdehyde 0.0174 0.0148 0.0147
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.002 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0084 0.0713
Loa Loa (eye worm) hypothetical protein 0.0097 0.0075 0.0667
Brugia malayi Isocitrate dehydrogenase 0.008 0.0059 0.052
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0133 0.0109 0.0962
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.0079 0.0078
Loa Loa (eye worm) transcription factor SMAD2 0.1204 0.1123 1
Schistosoma mansoni thyroid hormone receptor 0.0259 0.0229 0.0229
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0002 0.0001
Brugia malayi ImpB/MucB/SamB family protein 0.0078 0.0057 0.0501
Onchocerca volvulus 0.0023 0.0005 0.0031
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0082 0.0061 0.0061
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0023 0.0005 0.0004
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0002 0.0001
Echinococcus granulosus GPCR family 2 0.0306 0.0273 0.0272
Mycobacterium ulcerans dehydrogenase 0.0059 0.004 0.0522
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.0006 0.006
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.007 0.005 0.044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0043 0.0682
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0059 0.004 0.0346
Brugia malayi nuclear receptor RXR 0.0063 0.0043 0.0371
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0023 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0008 0.0055
Echinococcus granulosus hypothetical protein 0.0023 0.0005 0.0004
Trypanosoma cruzi NADH dehydrogenase, putative 0.0059 0.004 0.0624
Mycobacterium tuberculosis Conserved protein 0.0186 0.0159 0.024
Echinococcus multilocularis dro:myosuppressin receptor 0.0023 0.0005 0.0004
Giardia lamblia GTOR 0.0317 0.0283 0.6459
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0057 0.0917
Onchocerca volvulus 0.0023 0.0005 0.0031
Loa Loa (eye worm) hypothetical protein 0.0063 0.0043 0.0377
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0042 0.0042
Plasmodium vivax patched family protein, putative 0.0036 0.0018 0.0295
Loa Loa (eye worm) MH2 domain-containing protein 0.1204 0.1123 1
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0069 0.0048 0.0399
Brugia malayi nuclear hormone receptor family member odr-7 0.0063 0.0043 0.0371
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0044 0.0025 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.0009
Echinococcus granulosus 7tm_1 domain containing protein 0.0023 0.0005 0.0004
Brugia malayi steroid hormone receptor 0.0133 0.0109 0.0962
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0005 0.0004
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0059 0.004 0.0624
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0003 0.0022
Brugia malayi Patched family protein 0.0036 0.0018 0.0149
Brugia malayi MH2 domain containing protein 0.1204 0.1123 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0005 0.0004
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0002 0.0001
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0127 0.0103 0.0103
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0097 0.0075 0.0638
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0059 0.004 0.0329
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Onchocerca volvulus 0.0036 0.0018 0.0141
Loa Loa (eye worm) hypothetical protein 0.0047 0.0028 0.0243
Loa Loa (eye worm) hypothetical protein 0.0186 0.0159 0.1415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0085 0.0064 0.0538
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0005 0.0042
Schistosoma mansoni cpg binding protein 0.0123 0.01 0.01
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0063 0.0043 0.0042
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0059 0.004 0.0329
Brugia malayi Thioredoxin reductase 0.0647 0.0596 0.5301
Onchocerca volvulus 0.0133 0.0109 0.0931
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0059 0.004 0.0039
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0005 0.0004
Schistosoma mansoni biogenic amine receptor 0.0023 0.0005 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0042 0.0042
Trichomonas vaginalis penicillin-binding protein, putative 0.0186 0.0159 0.1364
Echinococcus granulosus mothers against decapentaplegic 5 0.0082 0.0061 0.006
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0014 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0187 0.0161 0.1378
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0003 0.0016
Mycobacterium ulcerans pyruvate kinase 0.0032 0.0014 0.0173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0043 0.0682
Schistosoma mansoni DNA polymerase eta 0.0078 0.0057 0.0057
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0317 0.0283 0.5157
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0049 0.003 0.0135
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1186 0.1106 0.1678
Echinococcus granulosus pyruvate kinase 0.0032 0.0014 0.0013
Schistosoma mansoni fkbp-rapamycin associated protein 0.006 0.004 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0171 0.0145 0.1242
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.002 0.029
Giardia lamblia NADH oxidase lateral transfer candidate 0.0224 0.0196 0.4441
Entamoeba histolytica hypothetical protein 0.0432 0.0393 0.7159
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.002 0.0003 0.0009
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0014 0.0186
Echinococcus granulosus survival motor neuron protein 1 0.0979 0.0911 0.091
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0317 0.0283 0.473
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0023 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0187 0.0161 0.1378
Echinococcus granulosus allatostatin A receptor 0.0023 0.0005 0.0004
Echinococcus multilocularis FTZ F1 alpha 0.0133 0.0109 0.0108
Echinococcus multilocularis cpg binding protein 0.0123 0.01 0.0099
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0317 0.0283 0.5157
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0115 0.0115
Loa Loa (eye worm) glutathione reductase 0.0647 0.0596 0.5304
Giardia lamblia PHD finger protein 15 0.0031 0.0013 0.0227
Echinococcus multilocularis protein patched 0.0256 0.0226 0.0225
Mycobacterium ulcerans Type I modular polyketide synthase 0.0051 0.0032 0.0411
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0023 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Echinococcus granulosus dro:myosuppressin receptor 0.0023 0.0005 0.0004
Brugia malayi Nuclear hormone receptor-like 1 0.0133 0.0109 0.0962
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0037 0.0019 0.0018
Loa Loa (eye worm) hypothetical protein 0.0078 0.0057 0.0507
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0186 0.0159 0.2147
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0023 0.0005 0.0036
Brugia malayi Patched family protein 0.0036 0.0018 0.0149
Brugia malayi jmjC domain containing protein 0.0046 0.0027 0.023
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.006 0.004 0.0349
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0224 0.0196 0.3252
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0063 0.0043 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0133 0.0109 0.0962
Loa Loa (eye worm) hypothetical protein 0.0133 0.0109 0.0968
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0059 0.004 0.0624
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0017 0.0131
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0224 0.0196 0.3252
Mycobacterium ulcerans Type I modular polyketide synthase 0.0051 0.0032 0.0411
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0078 0.0057 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0208 0.1787
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0005 0.0004
Schistosoma mansoni smad 0.0037 0.0018 0.0018
Brugia malayi AMP-binding enzyme family protein 0.0061 0.0041 0.0362
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Plasmodium vivax ataxin-2 like protein, putative 0.0205 0.0178 0.2982
Loa Loa (eye worm) hypothetical protein 0.0029 0.001 0.0091
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.002 0.0003 0.0009
Brugia malayi Melatonin receptor type 1A 0.0023 0.0005 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0133 0.0109 0.0968
Loa Loa (eye worm) MH2 domain-containing protein 0.0037 0.0018 0.0159
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.002 0.0003 0.0019
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0028 0.0041
Brugia malayi Nuclear hormone receptor-like 1 0.007 0.005 0.0435
Echinococcus granulosus cpg binding protein 0.0123 0.01 0.0099
Echinococcus granulosus g protein coupled receptor 0.0023 0.0005 0.0004
Chlamydia trachomatis recombinase RecA 0.0222 0.0194 0.2486
Echinococcus granulosus alpha 1A adrenergic receptor 0.0023 0.0005 0.0004
Loa Loa (eye worm) phosphatidylinositol kinase 0.002 0.0003 0.0022
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.015 0.0125 0.0125
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0076 0.0055 0.0082
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0023 0.0005 0.0042
Schistosoma mansoni hypothetical protein 0.002 0.0003 0.0003
Brugia malayi ecdysteroid receptor 0.0133 0.0109 0.0962
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0059 0.004 0.0624
Trypanosoma cruzi DNA polymerase eta, putative 0.0078 0.0057 0.0917
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0003 0.0016
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0013 0.011
Mycobacterium tuberculosis Probable esterase LipL 0.0186 0.0159 0.024
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0059 0.004 0.0174
Echinococcus granulosus ferritin 0.0069 0.0048 0.0048
Onchocerca volvulus 0.0023 0.0005 0.0031
Loa Loa (eye worm) phosphatidylinositol 3 0.0106 0.0084 0.0746
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0059 0.004 0.0624
Brugia malayi isocitrate dehydrogenase 0.008 0.0059 0.052
Loa Loa (eye worm) steroid hormone receptor 0.0133 0.0109 0.0968
Plasmodium falciparum glutathione reductase 0.0647 0.0596 1
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0006 0.006
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0027 0.0221
Onchocerca volvulus 0.0023 0.0005 0.0031
Loa Loa (eye worm) hypothetical protein 0.0133 0.0109 0.0968
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0006 0.006
Brugia malayi orphan nuclear receptor NR2E1 0.0063 0.0043 0.0371
Mycobacterium ulcerans NADH dehydrogenase 0.0059 0.004 0.0522
Mycobacterium ulcerans Type I modular polyketide synthase 0.0051 0.0032 0.0411
Brugia malayi Patched family protein 0.0036 0.0018 0.0149
Onchocerca volvulus 0.02 0.0172 0.1482
Loa Loa (eye worm) hypothetical protein 0.0047 0.0028 0.0248
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0043 0.0682
Echinococcus granulosus muscleblind protein 0.0146 0.0122 0.0121
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.002 0.017
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.002 0.029
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0479 0.0437 0.389
Plasmodium falciparum lipid/sterol:H+ symporter 0.0036 0.0018 0.0251
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0224 0.0196 0.1735
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0224 0.0196 0.2644
Onchocerca volvulus 0.0036 0.0018 0.0141
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.006 0.004 0.0333
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0005 0.0004
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.002 0.0003 0.0009
Schistosoma mansoni hypothetical protein 0.0306 0.0273 0.0273
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0059 0.004 0.0624
Loa Loa (eye worm) hypothetical protein 0.0175 0.0149 0.1325
Brugia malayi glutaminase DH11.1 0.0295 0.0263 0.2335
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0165 0.0139 0.1233
Trichomonas vaginalis CAMK family protein kinase 0.0479 0.0437 0.3771
Trypanosoma brucei hypothetical protein, conserved 0.0059 0.004 0.0624
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0023 0.0005 0.0036
Schistosoma mansoni smad1 5 8 and 0.0082 0.0061 0.0061
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0192 0.0166 0.0249
Leishmania major hypothetical protein, conserved 0.0205 0.0178 0.295
Schistosoma mansoni glutaminase 0.0295 0.0263 0.0263
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0224 0.0196 0.3252
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0133 0.0109 0.0962
Trichomonas vaginalis bromodomain-containing protein, putative 0.0087 0.0066 0.0556
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.002 0.0003 0.0009
Echinococcus granulosus geminin 0.1197 0.1117 0.1117
Onchocerca volvulus 0.0023 0.0005 0.0031
Onchocerca volvulus 0.0186 0.0159 0.1366
Leishmania major cathepsin L-like protease 0.0063 0.0043 0.0682
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0967 0.0899 0.8006
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0002 0.0001
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0006 0.006
Onchocerca volvulus 0.0023 0.0005 0.0031
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0059 0.004 0.0522
Mycobacterium leprae conserved hypothetical protein 0.0186 0.0159 0.0717
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0023 0.0005 0.0004
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.002 0.0003 0.0009
Schistosoma mansoni hypothetical protein 0.0127 0.0103 0.0103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0043 0.0682
Brugia malayi Patched related family protein 12 0.0036 0.0018 0.0149
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0015 0.0021
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1475 0.138 0.2095
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.002 0.0028
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0034 0.0016 0.0015
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0037 0.0019 0.0164
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0008 0.0055
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0037 0.0019 0.0158
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Echinococcus granulosus serine protein kinase ATM 0.006 0.004 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0003 0.0003
Schistosoma mansoni biogenic amine receptor 0.0023 0.0005 0.0005
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0032 0.0014 0.0019
Schistosoma mansoni hypothetical protein 0.0306 0.0273 0.0273
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0057 0.0917
Brugia malayi tailless protein 0.0063 0.0043 0.0371
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0017 0.021
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0014 0.0123
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0001 0.0004
Echinococcus granulosus mixed lineage leukemia protein mll 0.0034 0.0016 0.0015
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0059 0.004 0.0522
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Echinococcus multilocularis neuropeptide FF receptor 2 0.0023 0.0005 0.0004
Schistosoma mansoni jumonji domain containing protein 0.008 0.0059 0.0059
Treponema pallidum thioredoxin reductase (trxB) 0.0059 0.004 0.0276
Loa Loa (eye worm) hypothetical protein 0.0063 0.0043 0.0377
Loa Loa (eye worm) nuclear receptor NHR-67 0.0063 0.0043 0.0377
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0051 0.005
Mycobacterium ulcerans glutaminase 0.0295 0.0263 0.356
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0037 0.0019 0.0018
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0023 0.0005 0.0005
Echinococcus multilocularis beta LACTamase domain containing family member 0.0186 0.0159 0.0158
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0078 0.0057 0.048
Giardia lamblia DINP protein human, muc B family 0.0078 0.0057 0.1253
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0003 0.0016
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0317 0.0283 0.473
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0059 0.004 0.0624
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0059 0.004 0.0697
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0029 0.0011 0.0014
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0795 0.0736 0.0736
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0051 0.0032 0.0137
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0432 0.0393 0.0392
Onchocerca volvulus 0.0174 0.0148 0.1268
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0005 0.0004
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0059 0.004 0.0329
Mycobacterium ulcerans thioesterase TesA 0.0042 0.0023 0.0302
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0023 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0186 0.0159 0.1415
Echinococcus granulosus mothers against decapentaplegic 6 0.0037 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0063 0.0043 0.0377
Onchocerca volvulus Serine\/threonine kinase homolog 0.0479 0.0437 0.3773
Brugia malayi G protein-coupled receptor F59B2.13 0.0023 0.0005 0.0036
Loa Loa (eye worm) hypothetical protein 0.007 0.005 0.044
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0023 0.0005 0.0042
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0014 0.0127
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0317 0.0283 0.0283
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0005 0.0005
Echinococcus granulosus G protein coupled receptor 139 0.0023 0.0005 0.0004
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0224 0.0196 0.3282
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0133 0.0109 0.0962
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0158 0.0133 0.0133
Mycobacterium ulcerans hypothetical protein 0.0186 0.0159 0.2147
Mycobacterium ulcerans ferredoxin reductase 0.0059 0.004 0.0522
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0043 0.0682
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0059 0.004 0.0039
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0017 0.0238
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0647 0.0596 0.0903
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0046 0.0027 0.0026
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0317 0.0283 0.0283
Toxoplasma gondii patched family protein 0.0036 0.0018 0.0251
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0055 0.0035 0.0314
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0005 0.0004
Brugia malayi hypothetical protein 0.0023 0.0005 0.0036
Brugia malayi MH2 domain containing protein 0.0082 0.0061 0.0536
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0024 0.0006 0.006
Brugia malayi acetyltransferase, GNAT family protein 0.0291 0.0259 0.2296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0236 0.0206 0.1773
Leishmania major pyruvate kinase 0.0032 0.0014 0.0191
Loa Loa (eye worm) DR-78 0.0063 0.0043 0.0377
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0023 0.0005 0.0031
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0003 0.0016
Echinococcus granulosus Nuclear hormone receptor HR96 0.0063 0.0043 0.0042
Onchocerca volvulus 0.0061 0.0041 0.0348
Schistosoma mansoni growth hormone secretagogue receptor 0.0023 0.0005 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0008 0.0055
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0186 0.0159 0.0159
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0015 0.0021
Trypanosoma brucei DNA polymerase IV, putative 0.0078 0.0057 0.0917
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0186 0.0159 0.024
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0003 0.0022
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0078 0.0057 0.0056
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Loa Loa (eye worm) hypothetical protein 0.0661 0.0609 0.5425
Trypanosoma brucei DNA polymerase eta, putative 0.0078 0.0057 0.0917
Schistosoma mansoni hypothetical protein 0.0023 0.0005 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0158 0.0133 0.0133
Brugia malayi protein C24B5.3 0.0036 0.0018 0.0149
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.002 0.0158
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0005 0.0041
Schistosoma mansoni transcription factor LCR-F1 0.0432 0.0393 0.0392
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0049 0.003 0.0496
Schistosoma mansoni hypothetical protein 0.0246 0.0217 0.0217
Echinococcus multilocularis pyruvate kinase 0.0032 0.0014 0.0013
Plasmodium vivax hypothetical protein, conserved 0.002 0.0003 0.0045
Schistosoma mansoni apoferritin-2 0.0069 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.0246 0.0217 0.0217
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Brugia malayi hypothetical protein 0.0979 0.0911 0.8106
Treponema pallidum oxidoreductase 0.0059 0.004 0.0276
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0051 0.005
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0003 0.0002
Schistosoma mansoni survival motor neuron protein 0.02 0.0172 0.0172
Schistosoma mansoni myosin xvIII 0.0023 0.0005 0.0005
Echinococcus multilocularis thyroid hormone receptor alpha 0.0259 0.0229 0.0228
Leishmania major phosphatidylinositol 3-kinase, putative 0.0106 0.0084 0.1369
Mycobacterium tuberculosis Conserved protein 0.0186 0.0159 0.024
Brugia malayi Bromodomain containing protein 0.0086 0.0065 0.0574
Onchocerca volvulus 0.0186 0.0159 0.1366
Schistosoma mansoni alpha-1 adrenergic receptor 0.0023 0.0005 0.0005
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.002 0.0003 0.0019
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0037 0.0018 0.0025
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0033 0.0015 0.0201
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0582 0.0534 0.0534
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0034 0.0016 0.0015
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0043 0.0682
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0133 0.0109 0.0962
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.002 0.0003 0.0002
Echinococcus multilocularis GPCR, family 2 0.0306 0.0273 0.0272
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.002 0.0003 0.0002
Echinococcus granulosus zinc finger protein 0.0033 0.0014 0.0014
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.007 0.005 0.0049
Echinococcus multilocularis glutamate synthase 0.0059 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0045 0.0026 0.0233
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0005 0.0004
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0133 0.0109 0.0108
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Loa Loa (eye worm) hypothetical protein 0.0186 0.0159 0.1415
Entamoeba histolytica serine/threonine protein kinase, putative 0.0479 0.0437 0.7974
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0224 0.0196 0.0195
Echinococcus granulosus neuropeptide receptor A26 0.0023 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.007 0.005 0.044
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0224 0.0196 0.3252
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0059 0.004 0.0624
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0051 0.0032 0.0411
Loa Loa (eye worm) patched family protein 0.0036 0.0018 0.0155
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.002 0.0003 0.0009
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.006 0.004 0.063
Trypanosoma cruzi polo-like protein kinase, putative 0.0479 0.0437 0.7323
Brugia malayi hypothetical protein 0.0205 0.0178 0.1576
Giardia lamblia Glutamate synthase 0.0059 0.004 0.0852
Toxoplasma gondii thioredoxin reductase 0.0647 0.0596 1
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0795 0.0736 0.3338
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0059 0.004 0.0276
Loa Loa (eye worm) hypothetical protein 0.0205 0.0178 0.1581
Schistosoma mansoni neuropeptide receptor 0.0023 0.0005 0.0005
Echinococcus multilocularis Zinc finger, PHD finger 0.002 0.0003 0.0002
Trypanosoma cruzi PAB1-binding protein , putative 0.0205 0.0178 0.295
Giardia lamblia Histone acetyltransferase GCN5 0.0078 0.0057 0.1249
Echinococcus granulosus Smad4 0.0082 0.0061 0.006
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0069 0.0048 0.0072
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0023 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0146 0.0122 0.1081
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0037 0.0019 0.0147
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0175 0.0149 0.0149
Mycobacterium tuberculosis Probable hydrolase 0.0186 0.0159 0.024
Brugia malayi RE15519p 0.0023 0.0005 0.0036
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0041 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Loa Loa (eye worm) patched family protein 0.0036 0.0018 0.0155
Loa Loa (eye worm) jmjC domain-containing protein 0.0046 0.0027 0.0236
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0106 0.0084 0.1369
Brugia malayi N-terminal motif family protein 0.0352 0.0316 0.2811
Echinococcus granulosus 7TM GPCR rhodopsin 0.0023 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Loa Loa (eye worm) hypothetical protein 0.0035 0.0017 0.0147
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0019 0.0018
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0028 0.0483
Brugia malayi hypothetical protein 0.0019 0.0002 0.0007
Schistosoma mansoni nuclear receptor 0.0063 0.0043 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0171 0.0145 0.1244
Schistosoma mansoni nuclear receptor 0.0063 0.0043 0.0042
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0014 0.011
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0224 0.0196 0.3252
Onchocerca volvulus 0.002 0.0003 0.0012
Echinococcus multilocularis dna polymerase eta 0.0078 0.0057 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0133 0.0109 0.0962
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0059 0.004 0.0624
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0002 0.0001
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.008 0.0059 0.0953
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0222 0.1907
Echinococcus multilocularis isocitrate dehydrogenase 0.008 0.0059 0.0059
Schistosoma mansoni neuropeptide f receptor 76f 0.0023 0.0005 0.0005
Echinococcus multilocularis G-protein coupled receptor, putative 0.0023 0.0005 0.0004
Schistosoma mansoni ferritin light chain 0.0069 0.0048 0.0048
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0059 0.004 0.0329
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0059 0.004 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0057 0.0917
Brugia malayi Dopamine receptor 0.0023 0.0005 0.0036
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0005 0.0005
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0224 0.0196 0.3252
Echinococcus granulosus neuropeptide s receptor 0.0023 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Trypanosoma cruzi hypothetical protein, conserved 0.0186 0.0159 0.2637
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.0014 0.0117
Brugia malayi putative neuropeptide receptor 0.0023 0.0005 0.0036
Brugia malayi Pax transcription factor protein 2 0.0729 0.0673 0.5993
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0023 0.0005 0.0005
Schistosoma mansoni ferritin 0.0069 0.0048 0.0048
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0013 0.0166
Echinococcus granulosus regulator of G protein signaling 7 0.0037 0.0018 0.0017
Schistosoma mansoni ferritin 0.0069 0.0048 0.0048
Mycobacterium ulcerans lipoprotein LpqF 0.0192 0.0166 0.2235
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0016 0.0016
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0016 0.0016
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0023 0.0005 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0189 0.0163 0.1393
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0005 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0005 0.0004
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0024 0.0023
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0023 0.0005 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0005 0.0005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0115 0.0114
Loa Loa (eye worm) hypothetical protein 0.0313 0.028 0.2492
Schistosoma mansoni apoferritin-2 0.0069 0.0048 0.0048
Treponema pallidum bacterioferrin (TpF1) 0.0069 0.0048 0.0399
Onchocerca volvulus 0.0115 0.0092 0.0786
Echinococcus multilocularis regulator of G protein signaling 7 0.0037 0.0018 0.0017
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1475 0.138 0.6265
Onchocerca volvulus 0.0059 0.004 0.0332
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0028 0.0363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0171 0.0145 0.1242
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.002 0.0003 0.0016
Entamoeba histolytica thioredoxin reductase, putative 0.0059 0.004 0.0697
Entamoeba histolytica hypothetical protein 0.0432 0.0393 0.7159
Schistosoma mansoni ferritin 0.0069 0.0048 0.0048
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0352 0.0316 0.2727
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0014 0.0123
Loa Loa (eye worm) hypothetical protein 0.0069 0.0048 0.043
Plasmodium vivax hypothetical protein, conserved 0.0186 0.0159 0.267
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0005 0.0004
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0133 0.0109 0.0109
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.6971 0.6585 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0236 0.0206 0.1773
Trypanosoma brucei DNA polymerase IV, putative 0.0078 0.0057 0.0917
Trichomonas vaginalis mercuric reductase, putative 0.0224 0.0196 0.168
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0037 0.0019 0.0269
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0028 0.0363
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.006 0.004 0.0704
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0224 0.0196 0.2644
Mycobacterium tuberculosis Probable lipase LipD 0.0186 0.0159 0.024
Echinococcus granulosus dna polymerase eta 0.0078 0.0057 0.0056
Loa Loa (eye worm) hypothetical protein 0.0063 0.0043 0.0377
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0186 0.0159 0.1415
Loa Loa (eye worm) hypothetical protein 0.0063 0.0043 0.0377
Mycobacterium leprae Probable lipase LipE 0.0186 0.0159 0.0717
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0306 0.0273 0.2426
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.008 0.0059 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0043 0.0682
Loa Loa (eye worm) hypothetical protein 0.0979 0.0911 0.8107
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0106 0.0084 0.074
Brugia malayi Patched related family protein 10 0.0036 0.0018 0.0149
Brugia malayi regulator of G-protein signaling egl-10 0.0037 0.0018 0.0153
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0017 0.0023
Echinococcus granulosus dnaJ subfamily B 0.1194 0.1114 0.1113
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0106 0.0084 0.0083
Brugia malayi HSF-type DNA-binding domain containing protein 0.0097 0.0075 0.0661
Trypanosoma cruzi target of rapamycin kinase 3 0.0252 0.0222 0.3699
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0043 0.0682
Trichomonas vaginalis PIKK family atypical protein kinase 0.0317 0.0283 0.2439
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0013 0.0012
Echinococcus granulosus Niemann Pick C1 protein 0.0596 0.0548 0.0547
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0133 0.0109 0.0962
Brugia malayi hypothetical protein 0.0023 0.0005 0.0036
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.002 0.0333
Loa Loa (eye worm) histone methyltransferase 0.0041 0.0022 0.0198
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0133 0.0109 0.0108
Trypanosoma cruzi trypanothione reductase, putative 0.0647 0.0596 1
Echinococcus granulosus nuclear receptor nhr 48 0.0063 0.0043 0.0042
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0317 0.0283 0.0283
Onchocerca volvulus 0.0023 0.0005 0.0031
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0059 0.004 0.0329
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Echinococcus granulosus ecdysone induced protein 78C 0.0133 0.0109 0.0108
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0224 0.0196 0.3252
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.002 0.0003 0.0002
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0076 0.0055 0.0082
Echinococcus granulosus sex peptide receptor 0.0023 0.0005 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0256 0.0226 0.1939
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0002 0.0007
Schistosoma mansoni hypothetical protein 0.002 0.0002 0.0002
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0092 0.007 0.007
Schistosoma mansoni patched 1 0.0256 0.0226 0.0225
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0096 0.0075 0.0658
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0014 0.011
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0017 0.0131
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0028 0.0363
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0023 0.0005 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0008 0.0055
Loa Loa (eye worm) hypothetical protein 0.0037 0.0019 0.0165
Brugia malayi beta-lactamase 0.0186 0.0159 0.141
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0252 0.0222 0.3699
Brugia malayi Dopamine receptor protein 1 0.0023 0.0005 0.0036
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0249 0.0219 0.0219
Mycobacterium tuberculosis Probable reductase 0.1475 0.138 0.2095
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0063 0.0043 0.0042
Onchocerca volvulus 0.0729 0.0673 0.5819
Schistosoma mansoni hypothetical protein 0.0246 0.0217 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0008 0.0055
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0596 0.0548 1
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0059 0.004 0.0276
Mycobacterium tuberculosis Probable oxidoreductase 0.164 0.1536 0.2332
Schistosoma mansoni neuropeptide receptor 0.0023 0.0005 0.0005
Loa Loa (eye worm) patched family protein 0.0036 0.0018 0.0155
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.0079 0.0078
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0023 0.0005 0.0004
Echinococcus multilocularis protein dispatched 1 0.0292 0.026 0.0259
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0049 0.003 0.0135
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0059 0.004 0.0346
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0132 0.0108 0.1774
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1475 0.138 0.2095
Schistosoma mansoni glutamate synthase 0.0059 0.004 0.004
Echinococcus multilocularis Niemann Pick C1 protein 0.0596 0.0548 0.0547
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0291 0.0259 0.0258
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0063 0.0043 0.0357
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0002 0.0001
Loa Loa (eye worm) acetyltransferase 0.0291 0.0259 0.2301
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.002 0.0003 0.0002
Brugia malayi PXA domain containing protein 0.0019 0.0002 0.0007
Leishmania major phosphopantetheinyl transferase-like protein 0.0049 0.003 0.0453
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0005 0.0005
Trichomonas vaginalis CAMK family protein kinase 0.0479 0.0437 0.3771
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Loa Loa (eye worm) hypothetical protein 0.0133 0.0109 0.0968
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0054 0.0034 0.0531
Echinococcus granulosus tar DNA binding protein 0.0062 0.0042 0.0042
Schistosoma mansoni serine/threonine protein kinase 0.0479 0.0437 0.0437
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0005 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0133 0.0109 0.0968
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0186 0.0159 0.024
Onchocerca volvulus 0.0463 0.0422 0.3644
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.0057 0.0917
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0224 0.0196 0.3252
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.007 0.005 0.0049
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0224 0.0196 0.3252
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0054 0.0035 0.005
Trypanosoma brucei hypothetical protein, conserved 0.0049 0.003 0.0453
Echinococcus multilocularis neuropeptide s receptor 0.0023 0.0005 0.0004
Trichomonas vaginalis DNA polymerase eta, putative 0.0078 0.0057 0.048
Trypanosoma cruzi DNA polymerase eta, putative 0.0024 0.0006 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0006 0.006
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0256 0.0226 0.2007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0005 0.0005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0133 0.0109 0.0108
Trypanosoma cruzi hypothetical protein, conserved 0.0186 0.0159 0.2637
Echinococcus granulosus expressed conserved protein 0.056 0.0513 0.0513
Schistosoma mansoni smad1 5 8 and 0.0082 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0317 0.0283 0.2516
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0003 0.0002
Brugia malayi hypothetical protein 0.0023 0.0005 0.0036
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.002 0.0003 0.0022
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0059 0.004 0.0058
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0002 0.0001
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0002 0.0013
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0133 0.0109 0.0109
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0002 0.0019
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0005 0.0004
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1475 0.138 0.2095
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.008 0.0059 0.0059
Leishmania major DNA polymerase kappa, putative 0.0078 0.0057 0.0917
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0059 0.004 0.0039
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0059 0.004 0.0624
Loa Loa (eye worm) hypothetical protein 0.006 0.004 0.0355
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0005 0.0004
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0051 0.0032 0.0046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0005 0.0004
Brugia malayi beta-lactamase family protein 0.0186 0.0159 0.141
Brugia malayi Patched family protein 0.0036 0.0018 0.0149
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0002 0.0007
Leishmania major cathepsin L-like protease 0.0063 0.0043 0.0682
Schistosoma mansoni hypothetical protein 0.0246 0.0217 0.0217
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0186 0.0159 0.024
Brugia malayi Serotonin receptor 0.0023 0.0005 0.0036
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.002 0.0003 0.0003
Trypanosoma cruzi DNA repair protein, putative 0.0068 0.0048 0.0765
Leishmania major DNA polymerase eta, putative 0.0024 0.0006 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0236 0.0206 0.1773
Schistosoma mansoni DNA polymerase IV / kappa 0.0024 0.0006 0.0006
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0133 0.0109 0.0109
Loa Loa (eye worm) patched family protein 0.0036 0.0018 0.0155
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0224 0.0196 0.2453
Loa Loa (eye worm) hypothetical protein 0.0186 0.0159 0.1415
Brugia malayi AKH receptor 0.0023 0.0005 0.0036
Entamoeba histolytica hypothetical protein 0.006 0.004 0.0704
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0057 0.0917
Loa Loa (eye worm) Smad1 0.0082 0.0061 0.0542
Echinococcus multilocularis peregrin 0.004 0.0021 0.0021
Schistosoma mansoni phosphatidylinositol 4-kinase 0.002 0.0003 0.0003
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0023 0.0005 0.0036
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0063 0.0043 0.0042
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0134 0.0133
Brugia malayi MH1 domain containing protein 0.0045 0.0026 0.0227
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0605 0.0556 0.0556
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0008 0.0055
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0133 0.0109 0.0108
Echinococcus granulosus beta LACTamase domain containing family member 0.0186 0.0159 0.0158
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.002 0.0003 0.0019
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0024 0.0023
Echinococcus multilocularis mothers against decapentaplegic 5 0.0082 0.0061 0.006
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0317 0.0283 0.473
Schistosoma mansoni nuclear receptor nhr-48 0.0063 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0035 0.0017 0.0147
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0059 0.004 0.0346
Trichomonas vaginalis PIKK family atypical protein kinase 0.0236 0.0206 0.1773
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.6398 0.6043 0.9176
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0003 0.0002
Mycobacterium leprae Polyketide synthase Pks13 0.0076 0.0055 0.0245
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.008 0.0059 0.0953
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0017 0.0237
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0005 0.0042
Echinococcus multilocularis nuclear receptor nhr 48 0.0063 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0133 0.0109 0.0968
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0005 0.0004
Echinococcus multilocularis muscleblind protein 1 0.0146 0.0122 0.0121
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0028 0.0121
Echinococcus multilocularis expressed conserved protein 0.056 0.0513 0.0513
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.0006 0.006
Brugia malayi Patched family protein 0.0036 0.0018 0.0149
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0059 0.004 0.0039
Schistosoma mansoni neuropeptide receptor 0.0023 0.0005 0.0005
Schistosoma mansoni terminal deoxycytidyl transferase 0.0078 0.0057 0.0057
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0034 0.0015 0.0189
Brugia malayi Patched family protein 0.0036 0.0018 0.0149
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0059 0.004 0.0624
Brugia malayi protein C24B5.3 0.0036 0.0018 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0084 0.0713
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0014 0.0111
Loa Loa (eye worm) hypothetical protein 0.0967 0.0899 0.8006
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0224 0.0196 0.2453
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0017 0.0277
Loa Loa (eye worm) TYRA-2 protein 0.0023 0.0005 0.0042
Echinococcus granulosus histone acetyltransferase KAT2B 0.0087 0.0066 0.0065
Brugia malayi Patched family protein 0.0036 0.0018 0.0149
Mycobacterium ulcerans hypothetical protein 0.0059 0.004 0.0522
Loa Loa (eye worm) hypothetical protein 0.0352 0.0316 0.2815
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0008 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0057 0.0917
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0059 0.004 0.0624
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0174 0.0148 0.0148
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0046 0.0027 0.0026
Trichomonas vaginalis penicillin-binding protein, putative 0.0186 0.0159 0.1364
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.002 0.0003 0.0045
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0028 0.0242
Echinococcus multilocularis mothers against decapentaplegic 2 0.0037 0.0018 0.0017
Brugia malayi Niemann-Pick C1 protein precursor 0.0596 0.0548 0.4872
Loa Loa (eye worm) MH1 domain-containing protein 0.0082 0.0061 0.0542
Trichomonas vaginalis PIKK family atypical protein kinase 0.0171 0.0145 0.1244
Loa Loa (eye worm) hypothetical protein 0.0047 0.0028 0.0248
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.008 0.0059 0.0059
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.002 0.0003 0.0002
Leishmania major cathepsin L-like protease 0.0063 0.0043 0.0682
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0059 0.004 0.0697
Brugia malayi ImpB/MucB/SamB family protein 0.0078 0.0057 0.0501
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0224 0.0196 0.0295
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0061 0.0041 0.0368
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0063 0.0043 0.0357
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0049 0.003 0.0384
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.002 0.029
Brugia malayi hypothetical protein 0.0019 0.0002 0.0007
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0306 0.0273 0.0272
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0133 0.0109 0.0931
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0008 0.0055
Toxoplasma gondii histone lysine methyltransferase SET1 0.0233 0.0204 0.3389
Onchocerca volvulus 0.1239 0.1156 1
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0059 0.004 0.0352
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0005 0.0005
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0133 0.0109 0.0108
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0005 0.0004
Echinococcus multilocularis pyruvate kinase 0.0032 0.0014 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0133 0.0109 0.0968
Echinococcus multilocularis regulator of G protein signaling 7 0.0037 0.0018 0.0017
Brugia malayi hypothetical protein 0.0432 0.0393 0.349
Trypanosoma brucei DNA polymerase kappa, putative 0.0054 0.0034 0.0531
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0043 0.0682
Schistosoma mansoni glutamate synthase 0.0059 0.004 0.004
Brugia malayi Smad1 0.0082 0.0061 0.0536
Echinococcus granulosus neuropeptide receptor 0.0023 0.0005 0.0004
Loa Loa (eye worm) glutaminase 0.0295 0.0263 0.234
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0159
Echinococcus multilocularis Niemann Pick C1 protein 0.0852 0.079 0.0789
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0133 0.0109 0.0109
Brugia malayi CHE-14 protein 0.0256 0.0226 0.2002
Schistosoma mansoni ap endonuclease 0.0039 0.002 0.002
Brugia malayi RNA binding protein 0.0062 0.0042 0.0369
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0023 0.0005 0.0005
Mycobacterium ulcerans bacterioferritin BfrB 0.0069 0.0048 0.0641
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0008 0.0055
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0042 0.0375
Loa Loa (eye worm) beta-lactamase 0.0186 0.0159 0.1415
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.0134 0.1192
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0005 0.0004
Echinococcus granulosus expressed protein 0.0069 0.0048 0.0048
Onchocerca volvulus 0.0023 0.0005 0.0031
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0059 0.004 0.0852
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0028 0.001 0.0115
Schistosoma mansoni RAR-like nuclear receptor 0.0133 0.0109 0.0109
Treponema pallidum recombinase A 0.0222 0.0194 0.2425
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0067 0.0047 0.0739
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.002 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0059 0.004 0.0352
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.002 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0059 0.004 0.0666
Treponema pallidum NADH oxidase 0.0224 0.0196 0.2453
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Brugia malayi Patched family protein 0.0036 0.0018 0.0149
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Loa Loa (eye worm) hypothetical protein 0.0063 0.0043 0.0377
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0057 0.0917
Plasmodium falciparum ataxin-2 like protein, putative 0.0205 0.0178 0.295
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.002 0.0003 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0013
Brugia malayi Nuclear hormone receptor E75 0.0063 0.0043 0.0371
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0133 0.0109 0.0962
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0043 0.0682
Schistosoma mansoni cpg binding protein 0.0123 0.01 0.01
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0005 0.0004
Echinococcus granulosus g-protein coupled receptor 0.0023 0.0005 0.0004
Echinococcus multilocularis sterol regulatory element binding protein 0.0256 0.0226 0.0225
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0087 0.0066 0.0556
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.002 0.0003 0.0045
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0306 0.0273 0.0272
Loa Loa (eye worm) hypothetical protein 0.0087 0.0066 0.0587
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0043 0.0682
Onchocerca volvulus 0.0036 0.0018 0.0141
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0133 0.0109 0.0108
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0049 0.003 0.0043
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Echinococcus granulosus expressed protein 0.0033 0.0014 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0133 0.0109 0.0968
Trichomonas vaginalis glutamate synthase, putative 0.0059 0.004 0.0329
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0006 0.006
Brugia malayi PXA domain containing protein 0.0019 0.0002 0.0007
Schistosoma mansoni hypothetical protein 0.0306 0.0273 0.0273
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0222 0.0194 0.0873
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0002 0.0001
Echinococcus granulosus Niemann Pick C1 protein 0.0852 0.079 0.0789
Loa Loa (eye worm) patched family protein 0.0036 0.0018 0.0155
Loa Loa (eye worm) nuclear hormone receptor 0.0063 0.0043 0.0377
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0005 0.0005
Schistosoma mansoni alpha-glucosidase 0.0137 0.0113 0.0113
Trypanosoma brucei isocitrate dehydrogenase, putative 0.008 0.0059 0.0953
Echinococcus granulosus somatostatin receptor 0.0023 0.0005 0.0004
Echinococcus granulosus tumor protein p63 0.1719 0.1611 0.1611
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0023 0.0005 0.0036
Trypanosoma brucei glucosidase, putative 0.0035 0.0017 0.0238
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0037 0.0019 0.0269
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0014 0.0191
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0042 0.0023 0.0101
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0037 0.0019 0.0269
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0042 0.0023 0.0033
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0043 0.0682
Echinococcus multilocularis Smad4 0.0082 0.0061 0.006
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0054 0.0035 0.005
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0014 0.0186
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.002 0.0003 0.0019
Loa Loa (eye worm) RNA binding protein 0.0062 0.0042 0.0375
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.002 0.0003 0.0002
Loa Loa (eye worm) pax transcription factor protein 2 0.0729 0.0673 0.5995
Echinococcus granulosus fmrfamide receptor 0.0023 0.0005 0.0004
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.002 0.0253
Mycobacterium ulcerans DNA polymerase IV 0.0078 0.0057 0.0759
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0005 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0171 0.0145 0.1242
Schistosoma mansoni thyroid hormone receptor 0.0259 0.0229 0.0229
Loa Loa (eye worm) MH2 domain-containing protein 0.0082 0.0061 0.0542
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0028 0.0363
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0005 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0189 0.0163 0.1393
Brugia malayi hypothetical protein 0.0023 0.0005 0.0036
Schistosoma mansoni histamine h1 receptor 0.0023 0.0005 0.0005
Schistosoma mansoni amine GPCR 0.0023 0.0005 0.0005
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0054 0.0035 0.0151
Loa Loa (eye worm) hypothetical protein 0.0063 0.0043 0.0377
Onchocerca volvulus Fatty acid synthase homolog 0.0092 0.007 0.0596
Leishmania major pyruvate kinase 0.0032 0.0014 0.0191
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0005 0.0005
Schistosoma mansoni steroid hormone receptor ad4bp 0.0133 0.0109 0.0109
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0049 0.003 0.0044
Brugia malayi MH1 domain containing protein 0.0082 0.0061 0.0536
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0057 0.0917
Echinococcus granulosus thioredoxin glutathione reductase 0.065 0.0599 0.0599
Mycobacterium ulcerans hypothetical protein 0.0047 0.0028 0.0363
Plasmodium falciparum pyruvate kinase 0.0032 0.0014 0.0191
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0059 0.004 0.0522
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0022
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0051 0.0032 0.0137
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.0006 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0133 0.0109 0.0962
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0028 0.0427
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0003 0.0026
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Toxoplasma gondii isocitrate dehydrogenase 0.008 0.0059 0.0953
Schistosoma mansoni hypothetical protein 0.0059 0.004 0.004
Trichomonas vaginalis glutathione reductase, putative 0.0224 0.0196 0.168
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.0115 0.1021
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0021 0.0003 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0054 0.0034 0.0531
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0005 0.0005
Brugia malayi G-protein coupled receptor 0.0023 0.0005 0.0036
Echinococcus granulosus mothers against decapentaplegic 2 0.0037 0.0018 0.0017
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.006 0.004 0.0349
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0222 0.1907
Brugia malayi hypothetical protein 0.007 0.005 0.0435
Brugia malayi TAR-binding protein 0.0062 0.0042 0.0369
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0224 0.0196 0.3252
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0059 0.004 0.0039
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0037 0.0018 0.0145
Echinococcus multilocularis pyruvate kinase 0.0026 0.0008 0.0007
Onchocerca volvulus 0.0092 0.0071 0.0599
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0037 0.0019 0.0269
Echinococcus granulosus neuropeptide receptor 0.0023 0.0005 0.0004
Loa Loa (eye worm) isocitrate dehydrogenase 0.008 0.0059 0.0526
Schistosoma mansoni kinase 0.0243 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0054
Brugia malayi hypothetical protein 0.0132 0.0109 0.0962
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0084 0.0713
Echinococcus multilocularis dna polymerase kappa 0.0078 0.0057 0.0056
Brugia malayi Patched family protein 0.0036 0.0018 0.0149
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0133 0.0109 0.0108
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0115 0.0114
Echinococcus multilocularis serine protein kinase ATM 0.006 0.004 0.0039
Mycobacterium ulcerans recombinase A 0.0222 0.0194 0.2616
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0057 0.0917
Onchocerca volvulus 0.0023 0.0005 0.0031
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0069 0.0048 0.0214
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0041 0.0022 0.0022
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0063 0.0043 0.0042
Brugia malayi CXXC zinc finger family protein 0.0115 0.0092 0.0813
Trichomonas vaginalis PIKK family atypical protein kinase 0.0317 0.0283 0.2439
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0017 0.0131
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0432 0.0393 0.0392
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0006
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0059 0.004 0.0697
Mycobacterium leprae conserved hypothetical protein 0.002 0.0003 0.0006
Echinococcus multilocularis serotonin receptor 0.0023 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.006 0.004 0.0333
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0024 0.0006 0.006
Echinococcus granulosus neuropeptide FF receptor 2 0.0023 0.0005 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0005 0.0005
Mycobacterium ulcerans hypothetical protein 0.0024 0.0006 0.0067
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.002 0.0158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0222 0.1907
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0021 0.0165
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.008 0.0059 0.0953
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0005 0.0004
Brugia malayi MH2 domain containing protein 0.0082 0.0061 0.0536
Onchocerca volvulus Neuropeptide F receptor homolog 0.0023 0.0005 0.0031
Loa Loa (eye worm) hypothetical protein 0.0035 0.0017 0.0147
Brugia malayi ecdysone receptor 0.0063 0.0043 0.0371
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0005 0.0057
Schistosoma mansoni opsin-like receptor 0.0023 0.0005 0.0005
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.006 0.004 0.004
Echinococcus granulosus peregrin 0.004 0.0021 0.0021
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.002 0.0003 0.0002
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0005 0.0042
Schistosoma mansoni adenoreceptor 0.0023 0.0005 0.0005
Toxoplasma gondii ABC1 family protein 0.0186 0.0159 0.2637
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.002 0.0003 0.0019
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0013 0.021
Brugia malayi MH1 domain containing protein 0.0045 0.0026 0.0227
Brugia malayi hypothetical protein 0.0023 0.0005 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0178 0.1528
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0005 0.0005
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0003 0.0016
Echinococcus granulosus sterol regulatory element binding protein 0.0256 0.0226 0.0225
Toxoplasma gondii patched family protein 0.0036 0.0018 0.0251
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0059 0.004 0.0624
Brugia malayi PHD-finger family protein 0.0031 0.0013 0.0104
Onchocerca volvulus Protein ultraspiracle homolog 0.0133 0.0109 0.0931
Loa Loa (eye worm) MH1 domain-containing protein 0.0037 0.0018 0.0159
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0317 0.0283 0.473
Trichomonas vaginalis D-aminoacylase, putative 0.0186 0.0159 0.1364
Plasmodium falciparum DNA repair protein REV1, putative 0.0024 0.0006 0.006
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0967 0.0899 0.8005
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0165 0.0139 0.1233
Brugia malayi follicle stimulating hormone receptor 0.0494 0.0452 0.4016
Loa Loa (eye worm) hypothetical protein 0.0174 0.0148 0.1314
Echinococcus granulosus peptide allatostatin:somatostatin 0.0023 0.0005 0.0004
Brugia malayi FAT domain containing protein 0.0046 0.0027 0.0235
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0028 0.0041
Echinococcus granulosus Nuclear hormone receptor HR96 0.0063 0.0043 0.0042
Echinococcus multilocularis expressed protein 0.0033 0.0014 0.0014
Brugia malayi Patched family protein 0.0036 0.0018 0.0149
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.002 0.0003 0.0009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0063 0.0043 0.0042
Onchocerca volvulus 0.0252 0.0222 0.1907
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0002 0.0001
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0252 0.0222 0.3699
Trichomonas vaginalis PIKK family atypical protein kinase 0.027 0.0239 0.2059
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0059 0.004 0.0522
Mycobacterium ulcerans esterase/lipase LipP 0.0186 0.0159 0.2147
Onchocerca volvulus 0.0036 0.0018 0.0141
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0005 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0236 0.0206 0.1773
Schistosoma mansoni hypothetical protein 0.0306 0.0273 0.0273
Schistosoma mansoni sulfide quinone reductase 0.0059 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Loa Loa (eye worm) fatty acid synthase 0.005 0.0031 0.0274
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Loa Loa (eye worm) hypothetical protein 0.007 0.005 0.044
Toxoplasma gondii type I fatty acid synthase, putative 0.0036 0.0018 0.0252
Echinococcus multilocularis dnaJ subfamily B 0.1194 0.1114 0.1113
Trypanosoma brucei pyruvate kinase 1 0.0032 0.0014 0.0191
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0037 0.0019 0.0311
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0306 0.0273 0.0272
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0054 0.0035 0.0452
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.0033 0.0572
Leishmania major hypothetical protein, conserved 0.0059 0.004 0.0624
Mycobacterium tuberculosis Conserved protein 0.0186 0.0159 0.024
Trichomonas vaginalis PIKK family atypical protein kinase 0.006 0.004 0.0333
Plasmodium vivax hypothetical protein 0.002 0.0003 0.0045
Entamoeba histolytica hypothetical protein 0.0432 0.0393 0.7159
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.0479 0.0437 0.3771
Onchocerca volvulus Alhambra homolog 0.0031 0.0013 0.0097
Plasmodium falciparum phd finger protein, putative 0.0031 0.0013 0.0166
Leishmania major hypothetical protein, conserved 0.0186 0.0159 0.2637
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0017 0.028
Brugia malayi Patched family protein 0.0036 0.0018 0.0149
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.002 0.0176
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0133 0.0109 0.0968
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0008 0.0055
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0028 0.0363
Echinococcus granulosus orexin receptor type 2 0.0023 0.0005 0.0004
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0059 0.004 0.0039
Schistosoma mansoni Smad4 0.0037 0.0018 0.0018
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0059 0.004 0.0522
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0028 0.0427
Brugia malayi Myosin head containing protein 0.0036 0.0018 0.0149
Brugia malayi hypothetical protein 0.0463 0.0422 0.3754
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0023 0.0005 0.0005
Brugia malayi Latrophilin receptor protein 2 0.0306 0.0273 0.2426
Schistosoma mansoni smad 0.0082 0.0061 0.0061
Brugia malayi Patched related family protein 4 0.0036 0.0018 0.0149
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.002 0.0003 0.0002
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0037 0.0019 0.0313
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0003 0.0003
Mycobacterium leprae conserved hypothetical protein 0.0049 0.003 0.0128
Schistosoma mansoni jumonji/arid domain-containing protein 0.0046 0.0027 0.0026
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0002 0.0001
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.002 0.0334
Trichomonas vaginalis PIKK family atypical protein kinase 0.0189 0.0163 0.1393
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0059 0.004 0.0329
Toxoplasma gondii exonuclease III APE 0.0039 0.002 0.029
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0059 0.004 0.0697
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0021 0.0165
Treponema pallidum replicative DNA helicase (dnaB) 0.0795 0.0736 1
Brugia malayi G protein-coupled receptor 0.0023 0.0005 0.0036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0224 0.0196 0.3252
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0059 0.004 0.0666
Schistosoma mansoni Replicative DNA helicase 0.0795 0.0736 0.0736
Echinococcus granulosus tm gpcr rhodopsin 0.0582 0.0534 0.0534
Mycobacterium ulcerans polyketide synthase Pks9 0.0034 0.0015 0.0189
Echinococcus granulosus pyruvate kinase 0.0032 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0059 0.004 0.0039
Mycobacterium ulcerans polyketide synthase 0.0054 0.0035 0.0452
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0133 0.0109 0.0968
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0222 0.1907
Loa Loa (eye worm) hypothetical protein 0.0186 0.0159 0.1415
Brugia malayi Patched protein homolog 1 0.0036 0.0018 0.0149
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0028 0.0363
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0024 0.0006 0.006
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0017 0.0131
Trichomonas vaginalis glutaminase, putative 0.0295 0.0263 0.2263
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0003 0.0045
Toxoplasma gondii isocitrate dehydrogenase 0.008 0.0059 0.0953
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.164 0.1536 0.2332
Loa Loa (eye worm) hypothetical protein 0.0067 0.0047 0.0413
Brugia malayi hypothetical protein 0.0023 0.0005 0.0036
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0003 0.002
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0106 0.0084 0.0084
Echinococcus multilocularis serotonin receptor 0.0023 0.0005 0.0004
Mycobacterium ulcerans lipase LipD 0.0186 0.0159 0.2147
Brugia malayi putative neuropeptide receptor NPR1 0.0023 0.0005 0.0036
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0014 0.0121
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0174 0.0148 0.1309
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0059 0.004 0.0329
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0002 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0059 0.004 0.0624
Brugia malayi sulfakinin receptor protein 0.0023 0.0005 0.0036
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0005 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0171 0.0145 0.1244
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0224 0.0196 0.3282
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0004 0.0004
Onchocerca volvulus 0.0023 0.0005 0.0031
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0023 0.0005 0.0036
Brugia malayi Nuclear hormone receptor E75 0.0063 0.0043 0.0371
Plasmodium vivax pyruvate kinase, putative 0.0032 0.0014 0.0235
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0106 0.0084 0.1369
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0008 0.0055
Trichomonas vaginalis D-aminoacylase, putative 0.0186 0.0159 0.1364
Trypanosoma brucei DNA polymerase IV, putative 0.0078 0.0057 0.0917
Toxoplasma gondii FATC domain-containing protein 0.006 0.004 0.063
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0041
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0002 0.0001
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.002 0.0003 0.0002
Schistosoma mansoni hypothetical protein 0.0432 0.0393 0.0392
Brugia malayi hypothetical protein 0.0023 0.0005 0.0036
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.0057 0.0917
Brugia malayi Nuclear hormone receptor-like 1 0.007 0.005 0.0435
Onchocerca volvulus 0.0102 0.008 0.0684
Brugia malayi Patched family protein 0.0036 0.0018 0.0149
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.002 0.029
Loa Loa (eye worm) phosphatidylinositol 3 0.0317 0.0283 0.252
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0133 0.0109 0.0108
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0037 0.0019 0.0147
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.002 0.0396
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0059 0.004 0.0697
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0224 0.0196 0.3252
Plasmodium falciparum thioredoxin reductase 0.0647 0.0596 1
Schistosoma mansoni zinc finger protein 0.0033 0.0014 0.0014
Brugia malayi Dopamine receptor protein 2 0.0023 0.0005 0.0036
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0017 0.0238
Echinococcus granulosus dna polymerase kappa 0.0078 0.0057 0.0056
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0059 0.004 0.0624
Trypanosoma brucei unspecified product 0.0054 0.0034 0.0531
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.0115 0.1016
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0106 0.0084 0.1369
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0006 0.006
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0047 0.0028 0.0248
Echinococcus granulosus serine:threonine protein kinase SMG1 0.006 0.004 0.0039
Trichomonas vaginalis glutamate synthase, putative 0.0059 0.004 0.0329
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0005 0.0005
Plasmodium falciparum glutathione reductase 0.0224 0.0196 0.3252
Trichomonas vaginalis esterase, putative 0.0186 0.0159 0.1364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0236 0.0206 0.1773
Schistosoma mansoni hypothetical protein 0.0092 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0252 0.0222 0.1972
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0028 0.0483
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0133 0.0109 0.0109
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0028 0.0363
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Brugia malayi Bromodomain containing protein 0.004 0.0021 0.0183
Echinococcus granulosus glutamate synthase 0.0059 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0008 0.0055
Trypanosoma brucei beta lactamase 0.0192 0.0166 0.2746
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0013 0.0012
Trichomonas vaginalis rotamase, putative 0.0032 0.0014 0.0105
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0159
Brugia malayi larval opioid receptor 0.0023 0.0005 0.0036
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0042 0.0042
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0059 0.004 0.0058
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0008 0.0055
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0059 0.004 0.0058
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.0006 0.006
Toxoplasma gondii NADPH-glutathione reductase 0.0224 0.0196 0.3252
Brugia malayi neuropeptide F receptor 0.0023 0.0005 0.0036
Schistosoma mansoni bromodomain containing protein 0.0075 0.0054 0.0054
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0224 0.0196 0.3252
Schistosoma mansoni hypothetical protein 0.0023 0.0005 0.0005
Echinococcus granulosus FTZ F1 alpha 0.0133 0.0109 0.0108
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0015 0.0021
Entamoeba histolytica hypothetical protein 0.002 0.0003 0.0019
Echinococcus granulosus g protein coupled receptor 0.0023 0.0005 0.0004
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0059 0.004 0.0522
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0008 0.0055
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.002 0.0003 0.0009
Mycobacterium ulcerans bacterioferritin BfrA 0.0069 0.0048 0.0641
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0186 0.0159 0.141
Chlamydia trachomatis thioredoxin reductase 0.0059 0.004 0.0355
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0224 0.0196 0.0195
Echinococcus multilocularis ecdysone induced protein 78C 0.0133 0.0109 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0317 0.0283 0.2439
Loa Loa (eye worm) hypothetical protein 0.0039 0.0021 0.0183
Entamoeba histolytica hypothetical protein 0.0049 0.003 0.0512
Echinococcus multilocularis somatostatin receptor 0.0023 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Schistosoma mansoni regulator of G protein signaling 0.0037 0.0018 0.0018
Leishmania major NADH dehydrogenase, putative 0.0059 0.004 0.0624
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0002 0.0001
Entamoeba histolytica acetyltransferase, GNAT family 0.0078 0.0057 0.1013
Toxoplasma gondii patched family protein 0.0036 0.0018 0.0251
Giardia lamblia Thioredoxin reductase 0.0059 0.004 0.0852
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0013 0.0012
Onchocerca volvulus 0.0023 0.0005 0.0031
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0041 0.0022 0.0283
Brugia malayi hypothetical protein 0.0023 0.0005 0.0036
Loa Loa (eye worm) hypothetical protein 0.0063 0.0043 0.0377
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.02 0.0172 0.1529
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0059 0.004 0.0276
Toxoplasma gondii patched family protein 0.0036 0.0018 0.0251
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.011
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0092 0.007 0.007
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0078 0.0057 0.0507
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0795 0.0736 1
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0069 0.0048 0.0072
Echinococcus multilocularis tumor protein p63 0.1719 0.1611 0.1611
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0005 0.0004
Schistosoma mansoni biogenic amine receptor 0.0023 0.0005 0.0005
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0224 0.0196 0.3252
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0059 0.004 0.0329
Brugia malayi nuclear receptor NHR-88 0.0133 0.0109 0.0962
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0057 0.0917
Trichomonas vaginalis D-aminoacylase, putative 0.0186 0.0159 0.1364
Echinococcus multilocularis mothers against decapentaplegic 6 0.0037 0.0018 0.0017
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.015 0.0125 0.2065
Echinococcus multilocularis thioredoxin glutathione reductase 0.065 0.0599 0.0599
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Schistosoma mansoni pyruvate kinase 0.0032 0.0014 0.0014
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0002 0.0001
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0068 0.0048 0.0765
Brugia malayi hypothetical protein 0.0063 0.0043 0.0371
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.0057 0.0917
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.002 0.0019
Mycobacterium tuberculosis Probable lipase LipE 0.0186 0.0159 0.024
Brugia malayi hypothetical protein 0.007 0.005 0.0435
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.008 0.0059 0.0994
Entamoeba histolytica hypothetical protein 0.002 0.0003 0.0019
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0044 0.0387
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0306 0.0273 0.0272
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0063 0.0043 0.0371
Schistosoma mansoni rotamase 0.0033 0.0014 0.0014
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.008 0.0059 0.0059
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0054 0.0035 0.0452
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0224 0.0196 0.3252
Loa Loa (eye worm) hypothetical protein 0.0133 0.0109 0.0968
Toxoplasma gondii target of rapamycin (TOR), putative 0.0236 0.0206 0.3434
Echinococcus multilocularis geminin 0.1197 0.1117 0.1117
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0003 0.0026
Loa Loa (eye worm) programmed cell death 8 0.0059 0.004 0.0352
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0005 0.0004
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0078 0.0057 0.0085
Plasmodium vivax SET domain protein, putative 0.0158 0.0133 0.2236
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Leishmania major hypothetical protein, conserved 0.0059 0.004 0.0624
Schistosoma mansoni glutamate synthase 0.0059 0.004 0.004
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Plasmodium vivax ferrodoxin reductase, putative 0.0059 0.004 0.0666
Brugia malayi Tachykinin-like peptides receptor 99D 0.0023 0.0005 0.0036
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0014 0.0186
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0171 0.0145 0.1244
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Brugia malayi G-protein coupled receptor 0.0023 0.0005 0.0036
Schistosoma mansoni Smad4 0.0037 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0022
Echinococcus multilocularis neuropeptide receptor A26 0.0023 0.0005 0.0004
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0028 0.0121
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0037 0.0019 0.0018
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0054 0.0035 0.005
Brugia malayi glutathione reductase 0.0647 0.0596 0.5301
Echinococcus multilocularis 0.002 0.0003 0.0002
Brugia malayi Patched family protein 0.0036 0.0018 0.0149
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0054 0.0035 0.0151
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.002 0.029
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.008 0.0059 0.0059
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0003 0.0022
Trypanosoma cruzi polo-like protein kinase, putative 0.0479 0.0437 0.7323
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0014 0.011
Onchocerca volvulus 0.0023 0.0005 0.0031
Trypanosoma brucei pyruvate kinase 1, putative 0.0032 0.0014 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0236 0.0206 0.1773
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0224 0.0196 0.3252
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0133 0.0109 0.0108
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.006 0.004 0.063
Brugia malayi MH1 domain containing protein 0.0082 0.0061 0.0536
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0186 0.0159 0.0159
Trichomonas vaginalis CAMK family protein kinase 0.0479 0.0437 0.3771
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0087 0.0066 0.1064
Loa Loa (eye worm) hypothetical protein 0.0133 0.0109 0.0968
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0002 0.0001
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0017 0.0131
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0049 0.003 0.0044
Schistosoma mansoni nuclear hormone receptor 0.0063 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Onchocerca volvulus 0.0023 0.0005 0.0031
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0023 0.0005 0.0004
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0023 0.0005 0.0004
Onchocerca volvulus 0.0036 0.0018 0.0141
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0115 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0008 0.0055
Trichomonas vaginalis CAMK family protein kinase 0.0479 0.0437 0.3771
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0059 0.004 0.0039
Brugia malayi hypothetical protein 0.0036 0.0018 0.0149
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0133 0.0109 0.0108
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0035 0.0017 0.0147
Brugia malayi glutamate synthase 0.0059 0.004 0.0346
Schistosoma mansoni alpha glucosidase 0.0035 0.0017 0.0017
Brugia malayi nuclear receptor RXR 0.007 0.005 0.0435
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0317 0.0283 0.473
Schistosoma mansoni pyruvate kinase 0.0032 0.0014 0.0014
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0133 0.0109 0.0109
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0224 0.0196 0.3252
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0049 0.003 0.0384
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.002 0.0003 0.0019
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0078 0.0057 0.0057
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0224 0.0196 0.3252
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0059 0.004 0.0624
Chlamydia trachomatis replicative DNA helicase 0.0795 0.0736 1
Toxoplasma gondii LsmAD domain-containing protein 0.0205 0.0178 0.295
Schistosoma mansoni jumonji/arid domain-containing protein 0.0046 0.0027 0.0026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0043 0.0682
Loa Loa (eye worm) hypothetical protein 0.0053 0.0033 0.0296
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.002 0.0003 0.0003
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0059 0.004 0.0174
Brugia malayi hypothetical protein 0.0036 0.0018 0.0149
Schistosoma mansoni hypothetical protein 0.1194 0.1114 0.1114
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.0014 0.0191
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0023 0.0005 0.0005
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0596 0.0548 0.4875
Echinococcus multilocularis L aminoadipate semialdehyde 0.0174 0.0148 0.0147
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0479 0.0437 0.7323
Echinococcus multilocularis g-protein coupled receptor 0.0023 0.0005 0.0004
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0017 0.0016
Loa Loa (eye worm) glutaminase 2 0.0295 0.0263 0.234
Loa Loa (eye worm) nuclear factor I 0.0045 0.0026 0.0233
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.002 0.0003 0.0002
Trypanosoma cruzi DNA repair protein, putative 0.0068 0.0048 0.0765
Brugia malayi polk-prov protein 0.0024 0.0006 0.0048
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0017 0.0131
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0291 0.0259 0.0258
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Loa Loa (eye worm) hypothetical protein 0.0306 0.0273 0.2431
Echinococcus granulosus serotonin receptor 0.0023 0.0005 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0059 0.004 0.0624
Loa Loa (eye worm) hypothetical protein 0.0035 0.0017 0.0147
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0003 0.0022
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0013
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0037 0.0019 0.0269
Loa Loa (eye worm) hypothetical protein 0.0133 0.0109 0.0968
Echinococcus granulosus tachykinin peptides receptor 99D 0.0023 0.0005 0.0004
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.164 0.1536 0.6973
Onchocerca volvulus 0.0036 0.0018 0.0141
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0224 0.0196 0.3252
Entamoeba histolytica disulphide oxidoreductase, putative 0.0059 0.004 0.0697
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0241
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0133 0.0109 0.0108
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0049 0.003 0.0453
Schistosoma mansoni coup transcription factor 0.0133 0.0109 0.0109
Trichomonas vaginalis CAMK family protein kinase 0.0479 0.0437 0.3771
Brugia malayi Serotonin receptor 0.0023 0.0005 0.0036
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0005 0.0004
Schistosoma mansoni amine GPCR 0.0023 0.0005 0.0005
Entamoeba histolytica heat shock transcription factor, putative 0.0097 0.0075 0.1345
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.002 0.0003 0.0002
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0017 0.0131
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0005 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0005 0.0004
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0479 0.0437 0.0436
Plasmodium falciparum thioredoxin reductase 0.0224 0.0196 0.3252
Schistosoma mansoni ferritin light chain 0.0069 0.0048 0.0048
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0059 0.004 0.0174
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.002 0.0003 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0084 0.0713
Loa Loa (eye worm) hypothetical protein 0.0133 0.0109 0.0968
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0059 0.004 0.0174
Giardia lamblia Pyruvate kinase 0.0032 0.0014 0.0261
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1088 0.1014 0.9029
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0059 0.004 0.0058
Leishmania major DNA damage repair protein, putative 0.0024 0.0006 0.006
Echinococcus multilocularis expressed protein 0.0376 0.034 0.0339
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0175 0.0149 0.0149
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0014 0.0186
Brugia malayi beta-lactamase family protein 0.0186 0.0159 0.141
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.006 0.004 0.063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0222 0.1907
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0224 0.0196 0.0195
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0061 0.0041 0.0061
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0401 0.0363 0.4922
Loa Loa (eye worm) hypothetical protein 0.0256 0.0226 0.2007
Onchocerca volvulus 0.0036 0.0018 0.0141
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0013 0.0166
Schistosoma mansoni hypothetical protein 0.02 0.0172 0.0172
Trypanosoma cruzi trypanothione reductase, putative 0.0224 0.0196 0.3252
Brugia malayi F/Y-rich N-terminus family protein 0.0053 0.0033 0.0289
Trypanosoma cruzi PAB1-binding protein , putative 0.0205 0.0178 0.295
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0133 0.0109 0.0962
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0017 0.0238
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0115 0.0115
Trypanosoma brucei unspecified product 0.0078 0.0057 0.0917
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0005 0.0004
Onchocerca volvulus 0.0023 0.0005 0.0031
Schistosoma mansoni opsin-like receptor 0.0023 0.0005 0.0005
Entamoeba histolytica hypothetical protein 0.0432 0.0393 0.7159
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0005 0.0004
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0005 0.0004
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0002 0.0007
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0049 0.003 0.0216
Trypanosoma brucei polo-like protein kinase 0.0479 0.0437 0.7323
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0192 0.0166 0.0746
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0494 0.0452 0.402
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0005 0.0042
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0028 0.0427
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0059 0.004 0.0329
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0059 0.004 0.0039
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0028 0.001 0.001
Brugia malayi neuropeptide F receptor 0.0023 0.0005 0.0036
Plasmodium falciparum histone acetyltransferase GCN5 0.0078 0.0057 0.0915
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.002 0.0003 0.0009
Mycobacterium ulcerans monoxygenase 0.0059 0.004 0.0522
Onchocerca volvulus 0.0023 0.0005 0.0031
Trichomonas vaginalis CAMK family protein kinase 0.0479 0.0437 0.3771
Schistosoma mansoni nuclear hormone receptor 0.0133 0.0109 0.0109
Schistosoma mansoni retinoid-x-receptor (RXR) 0.007 0.005 0.0049
Mycobacterium leprae Conserved hypothetical protein 0.2344 0.2203 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0175 0.0149 0.0148
Onchocerca volvulus 0.0047 0.0028 0.0231
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0059 0.004 0.0624
Entamoeba histolytica heat shock transcription factor, putative 0.0097 0.0075 0.1345
Schistosoma mansoni z-protein (S1r protein) 0.0037 0.0018 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0133 0.0109 0.0962
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0041 0.0022 0.0094
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.008 0.0059 0.0953
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.006 0.004 0.0039
Trypanosoma brucei NADH dehydrogenase 0.0059 0.004 0.0624
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0017 0.0277
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0014 0.0123
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0087 0.0066 0.1064
Schistosoma mansoni hypothetical protein 0.1197 0.1117 0.1117
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0008 0.0055
Brugia malayi hypothetical protein 0.0063 0.0043 0.0371
Echinococcus multilocularis expressed protein 0.0069 0.0048 0.0048
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.002 0.0003 0.0009
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0003 0.0022
Onchocerca volvulus Bile acid receptor homolog 0.0133 0.0109 0.0931
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0037 0.0018 0.0159
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0042 0.0042
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0059 0.004 0.0058
Trichomonas vaginalis ferritin, putative 0.0069 0.0048 0.0405
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0034 0.0015 0.0063
Brugia malayi mothers against decapentaplegic homolog 3 0.0037 0.0018 0.0153
Plasmodium falciparum ferrodoxin reductase-like protein 0.0059 0.004 0.0624
Loa Loa (eye worm) hypothetical protein 0.0063 0.0043 0.0377
Echinococcus multilocularis G protein coupled receptor 139 0.0023 0.0005 0.0004
Brugia malayi ORL1-like opioid receptor 0.0023 0.0005 0.0036
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0063 0.0043 0.0042
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0401 0.0363 0.0549
Brugia malayi conserved hypotetical protein 0.0063 0.0043 0.0371
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0317 0.0283 0.473
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0023 0.0005 0.0004
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0002 0.0001
Trichomonas vaginalis rotamase, putative 0.0033 0.0014 0.0111
Brugia malayi Patched family protein 0.0036 0.0018 0.0149
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Echinococcus granulosus regulator of G protein signaling 7 0.0037 0.0018 0.0017
Mycobacterium ulcerans thioesterase 0.0042 0.0023 0.0302
Leishmania major DNA polymerase kappa, putative 0.0024 0.0006 0.006
Schistosoma mansoni hypothetical protein 0.0661 0.0609 0.0609
Loa Loa (eye worm) hypothetical protein 0.0065 0.0044 0.0394
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Echinococcus granulosus smad 0.0082 0.0061 0.006
Trichomonas vaginalis helicase, putative 0.0026 0.0008 0.0055
Schistosoma mansoni hypothetical protein 0.0046 0.0027 0.0027
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0059 0.004 0.0624
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0023 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0123
Brugia malayi hypothetical protein 0.0036 0.0018 0.0149
Mycobacterium tuberculosis Probable thioesterase TesA 0.0042 0.0023 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0005 0.0005
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.002 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0146 0.0122 0.1081
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.002 0.0003 0.0009
Plasmodium vivax thioredoxin reductase, putative 0.0647 0.0596 1
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0017 0.0238
Echinococcus granulosus lysine specific demethylase 5A 0.0046 0.0027 0.0026
Brugia malayi photoreceptor-specific nuclear receptor 0.0133 0.0109 0.0962
Entamoeba histolytica hypothetical protein 0.002 0.0003 0.0019
Onchocerca volvulus Protein patched homolog 0.0036 0.0018 0.0141
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0051 0.0032 0.0046
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0133 0.0109 0.0108
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0063 0.0043 0.0377
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Onchocerca volvulus 0.0063 0.0043 0.0357
Onchocerca volvulus 0.0031 0.0013 0.01
Trichomonas vaginalis apoptosis inducing factor, putative 0.0059 0.004 0.0329
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0127 0.0103 0.0103
Brugia malayi nuclear receptor NHR-88 0.0063 0.0043 0.0371
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.008 0.0059 0.0088
Loa Loa (eye worm) hypothetical protein 0.0063 0.0043 0.0377
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0059 0.004 0.0624
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0017 0.0131
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0059 0.004 0.0624
Schistosoma mansoni retinoic acid receptor RXR 0.0133 0.0109 0.0109
Toxoplasma gondii selenide, water dikinase 0.0059 0.004 0.0624
Schistosoma mansoni disulfide oxidoreductase 0.0059 0.004 0.004
Schistosoma mansoni hypothetical protein 0.0031 0.0013 0.0012
Mycobacterium ulcerans DNA polymerase IV 0.0078 0.0057 0.0759
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Mycobacterium ulcerans glutamate synthase subunit beta 0.0059 0.004 0.0522
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0078 0.0057 0.0917
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0042 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0133 0.0109 0.0962
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0059 0.004 0.0329
Giardia lamblia DNA damage repair protein 0.0024 0.0006 0.0082
Toxoplasma gondii hypothetical protein 0.0036 0.0018 0.0251
Echinococcus granulosus g protein coupled receptor 0.0023 0.0005 0.0004
Loa Loa (eye worm) acyl carrier protein 0.0023 0.0005 0.0047
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.002 0.0003 0.0003
Brugia malayi hypothetical protein 0.0023 0.0005 0.0036
Schistosoma mansoni hypothetical protein 0.1197 0.1117 0.1117
Brugia malayi nuclear hormone receptor 0.0063 0.0043 0.0371
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0014 0.0186
Trypanosoma cruzi NADH dehydrogenase, putative 0.0059 0.004 0.0624
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.002 0.0003 0.0045
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0037 0.0019 0.0164
Schistosoma mansoni amine GPCR 0.0023 0.0005 0.0005
Brugia malayi jmjC domain containing protein 0.0101 0.0079 0.0696
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.003 0.0466
Giardia lamblia Kinase, PLK 0.0479 0.0437 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.0014 0.0117
Loa Loa (eye worm) twinkle helicase 0.0227 0.0198 0.1765
Schistosoma mansoni phosphatidylinositol 4-kinase 0.002 0.0003 0.0003
Brugia malayi Steroid receptor seven-up type 2 0.0133 0.0109 0.0962
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.008 0.0059 0.0953
Echinococcus multilocularis muscleblind protein 0.0146 0.0122 0.0121
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Schistosoma mansoni cpg binding protein 0.0115 0.0092 0.0092
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0133 0.0109 0.0968
Brugia malayi Patched family protein 0.0036 0.0018 0.0149
Trichomonas vaginalis set domain proteins, putative 0.1239 0.1156 1
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0059 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0013
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0134 0.0133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0043 0.0682
Mycobacterium leprae Probable pyruvate kinase PykA 0.0032 0.0014 0.0058
Echinococcus multilocularis allatostatin A receptor 0.0023 0.0005 0.0004
Schistosoma mansoni sulfide quinone reductase 0.0059 0.004 0.004
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0017 0.0142
Schistosoma mansoni opsin-like receptor 0.0023 0.0005 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0115 0.0114
Plasmodium vivax glutathione reductase, putative 0.0647 0.0596 1
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0795 0.0736 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0043 0.0682
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0017 0.0148
Mycobacterium ulcerans beta-lactamase 0.0186 0.0159 0.2147
Echinococcus granulosus fetal alzheimer antigen falz 0.0028 0.001 0.001
Onchocerca volvulus 0.002 0.0003 0.0012
Leishmania major hypothetical protein, conserved 0.0059 0.004 0.0624
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0087 0.0066 0.1104
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.007 0.005 0.0049
Schistosoma mansoni cellular tumor antigen P53 0.0252 0.0222 0.0221
Toxoplasma gondii type I fatty acid synthase, putative 0.0056 0.0036 0.0567
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0057 0.0917
Mycobacterium leprae Probable polyketide synthase Pks1 0.0054 0.0035 0.0151
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0034 0.0016 0.0015
Echinococcus multilocularis zinc finger protein 0.0033 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0186 0.0159 0.1415
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0014 0.0107
Brugia malayi Calcitonin receptor-like protein seb-1 0.0967 0.0899 0.8005
Brugia malayi Muscleblind-like protein 0.0146 0.0122 0.1075
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.0134 0.0133
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0003 0.0016
Brugia malayi GnHR receptor homolog 0.0023 0.0005 0.0036
Loa Loa (eye worm) hypothetical protein 0.0063 0.0043 0.0377
Brugia malayi nuclear hormone receptor 0.0133 0.0109 0.0962
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0158 0.0133 0.2201
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0106 0.0084 0.1369
Echinococcus granulosus thyroid hormone receptor alpha 0.0063 0.0043 0.0042
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0041 0.0022 0.0283
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0042
Brugia malayi PHD-finger family protein 0.0038 0.0019 0.0163
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0479 0.0437 0.0436
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0005 0.0004
Schistosoma mansoni amine GPCR 0.0023 0.0005 0.0005
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0005 0.0004
Schistosoma mansoni Smad4 0.0082 0.0061 0.0061
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0059 0.004 0.0058
Loa Loa (eye worm) CXXC zinc finger family protein 0.0115 0.0092 0.0819
Schistosoma mansoni alpha-glucosidase 0.0137 0.0113 0.0113
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0224 0.0196 0.2514
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0017 0.0038
Schistosoma mansoni amine GPCR 0.0023 0.0005 0.0005
Leishmania major trypanothione reductase 0.0647 0.0596 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0051 0.0032 0.0046
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0008 0.0055
Echinococcus granulosus TGF beta signal transducer SmadC 0.0082 0.0061 0.006
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0002 0.0001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0306 0.0273 0.2431
Echinococcus granulosus expressed protein 0.0376 0.034 0.0339
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0208 0.1787
Echinococcus multilocularis ferritin 0.0069 0.0048 0.0048
Brugia malayi Bromodomain containing protein 0.0044 0.0025 0.0218
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1475 0.138 0.2095
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.008 0.0059 0.0059
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0028 0.001 0.001
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.0134 0.1187
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0039 0.0021 0.0304
Schistosoma mansoni ap endonuclease 0.0039 0.002 0.002
Mycobacterium ulcerans polyketide synthase Pks13 0.0076 0.0055 0.0735
Entamoeba histolytica hypothetical protein 0.002 0.0003 0.0019
Loa Loa (eye worm) thioredoxin reductase 0.0647 0.0596 0.5304
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0155
Loa Loa (eye worm) hypothetical protein 0.007 0.005 0.044
Mycobacterium ulcerans polyketide synthase 0.0051 0.0032 0.0411
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0224 0.0196 0.2644
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0049 0.003 0.0453
Plasmodium vivax DNA repair protein REV1, putative 0.0024 0.0006 0.0104
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.0057 0.0917
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0051 0.0032 0.0273
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0002 0.0001
Mycobacterium tuberculosis Probable dehydrogenase 0.1475 0.138 0.2095
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0003 0.0009
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0028 0.0242
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0042 0.0042
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0002 0.0007
Brugia malayi MH2 domain containing protein 0.0037 0.0018 0.0153
Schistosoma mansoni zinc finger protein 0.0063 0.0043 0.0042
Brugia malayi serine/threonine-protein kinase plk-2 0.0479 0.0437 0.3886
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0037 0.0019 0.0269
Brugia malayi nuclear receptor NHR-67 0.0063 0.0043 0.0371
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.002 0.0003 0.0002
Onchocerca volvulus 0.0186 0.0159 0.1366
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0082 0.0061 0.006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0158 0.0133 0.0133
Leishmania major DNA polymerase eta, putative 0.0078 0.0057 0.0917
Plasmodium falciparum ataxin-2 like protein, putative 0.0205 0.0178 0.295
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0049 0.003 0.0453
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.002 0.0003 0.0003

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.9953 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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