Detailed information for compound 1068818

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 665.829 | Formula: C33H51N11O4
  • H donors: 9 H acceptors: 4 LogP: 0.05 Rotable bonds: 26
    Rule of 5 violations (Lipinski): 3
  • SMILES: NCc1cccc(c1)CNC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)Cc1ccccc1)CCCNC(=N)N)CCCNC(=N)N
  • InChi: 1S/C33H51N11O4/c1-21(2)28(44-30(47)26(14-8-16-40-33(37)38)42-27(45)18-22-9-4-3-5-10-22)31(48)43-25(13-7-15-39-32(35)36)29(46)41-20-24-12-6-11-23(17-24)19-34/h3-6,9-12,17,21,25-26,28H,7-8,13-16,18-20,34H2,1-2H3,(H,41,46)(H,42,45)(H,43,48)(H,44,47)(H4,35,36,39)(H4,37,38,40)/t25-,26-,28-/m0/s1
  • InChiKey: GCXHRMNYDWBUJY-NSVAZKTRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens furin (paired basic amino acid cleaving enzyme) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) endoprotease bli-4 Get druggable targets OG5_127788 All targets in OG5_127788
Schistosoma japonicum Proprotein convertase subtilisin/kexin type 6 precursor, putative Get druggable targets OG5_127788 All targets in OG5_127788
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase Get druggable targets OG5_127788 All targets in OG5_127788
Brugia malayi celfurPC protein Get druggable targets OG5_127788 All targets in OG5_127788
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127788 All targets in OG5_127788
Schistosoma japonicum Furin-like protease 1, isoforms 1/1-X/2 precursor, putative Get druggable targets OG5_127788 All targets in OG5_127788
Giardia lamblia High cysteine membrane protein Group 2 Get druggable targets OG5_127788 All targets in OG5_127788
Echinococcus multilocularis Get druggable targets OG5_127788 All targets in OG5_127788
Schistosoma japonicum Endoprotease bli-4 precursor, putative Get druggable targets OG5_127788 All targets in OG5_127788
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127788 All targets in OG5_127788
Candida albicans subtilisin-like endoprotease involved in processing C. albicans Sap2 Get druggable targets OG5_127788 All targets in OG5_127788
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) Get druggable targets OG5_127788 All targets in OG5_127788
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 Get druggable targets OG5_127788 All targets in OG5_127788
Echinococcus granulosus furin Get druggable targets OG5_127788 All targets in OG5_127788
Candida albicans subtilisin-like endoprotease involved in processing C. albicans Sap2 Get druggable targets OG5_127788 All targets in OG5_127788
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase Get druggable targets OG5_127788 All targets in OG5_127788
Brugia malayi endoprotease bli-4 precursor Get druggable targets OG5_127788 All targets in OG5_127788
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 Get druggable targets OG5_127788 All targets in OG5_127788
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.1212 0.1212
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2965 0.3541
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.1685 0.2896
Schistosoma mansoni hypothetical protein 0.0034 0.0555 0.0948
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.1176 0.1172
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.4054 0.4052
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0813 0.0968
Loa Loa (eye worm) proprotein convertase 2 0.0042 0.0813 0.0491
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.1685 0.2258
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2965 0.3541
Brugia malayi proprotein convertase 2 0.0111 0.3189 0.3189
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0796 0.4712
Brugia malayi glutathione reductase 0.0052 0.1176 0.1176
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2965 0.3541
Brugia malayi Pre-SET motif family protein 0.0033 0.0515 0.0515
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2965 0.3541
Plasmodium falciparum glutathione reductase 0.0052 0.1176 1
Brugia malayi hypothetical protein 0.0028 0.0339 0.0339
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.4189 0.721
Loa Loa (eye worm) hypothetical protein 0.0038 0.0675 0.0348
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0027 0.0312 0.0413
Giardia lamblia Kinase, PLK 0.0105 0.2965 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1117 0.1114
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0576 0.0985
Schistosoma mansoni hypothetical protein 0.0188 0.5808 1
Leishmania major hypothetical protein, conserved 0.0236 0.7449 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0339 0.2855
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0339 0.0449
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0027 0.0312 0.0784
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0555 0.0658
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0555 0.0658
Echinococcus granulosus survival motor neuron protein 1 0.0262 0.8349 0.8348
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0555 0.0658
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.1685 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.1759 0.147
Mycobacterium tuberculosis Probable oxidoreductase 0.0133 0.3929 1
Plasmodium vivax SET domain protein, putative 0.0033 0.0515 0.4358
Schistosoma mansoni furin-1 (S08 family) 0.0077 0.2018 0.3469
Echinococcus multilocularis Furin 1 0.0042 0.0813 0.081
Brugia malayi celfurPC protein 0.0143 0.4268 0.4268
Mycobacterium tuberculosis Probable dehydrogenase 0.012 0.3473 0.8837
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0339 0.199
Echinococcus granulosus L aminoadipate semialdehyde 0.0092 0.2535 0.2532
Entamoeba histolytica hypothetical protein 0.0035 0.0576 0.1137
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0105 0.2965 0.2962
Brugia malayi serine/threonine-protein kinase plk-2 0.0105 0.2965 0.2965
Trichomonas vaginalis hypothetical protein 0.0034 0.0555 0.0658
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.1176 0.1172
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0796 0.4712
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0027 0.0312 0.183
Brugia malayi Pre-SET motif family protein 0.0231 0.7274 0.7274
Schistosoma mansoni hypothetical protein 0.0035 0.0576 0.0985
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.012 0.3473 0.8837
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0092 0.2535 0.4361
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0034 0.0555 0.0658
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0027 0.0312 0.0413
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.3064 0.366
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.2965 0.5101
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.1685 0.4283
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0515 0.0511
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0679 0.5755
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.1685 0.1682
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2965 0.3541
Loa Loa (eye worm) hypothetical protein 0.0033 0.0515 0.0182
Toxoplasma gondii thioredoxin reductase 0.0052 0.1176 0.697
Loa Loa (eye worm) endoprotease bli-4 0.0177 0.544 0.528
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1117 0.1114
Echinococcus multilocularis geminin 0.0188 0.5808 0.5806
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0576 0.0572
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.012 0.3473 0.8753
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0555 0.0658
Echinococcus multilocularis citrate lyase subunit beta protein 0.0027 0.0312 0.0308
Trypanosoma brucei hypothetical protein, conserved 0.0236 0.7449 1
Echinococcus granulosus Furin 1 0.0042 0.0813 0.081
Loa Loa (eye worm) hypothetical protein 0.0055 0.1273 0.0967
Brugia malayi neuroendocrine convertase 1 precursor 0.0111 0.3189 0.3189
Entamoeba histolytica serine/threonine protein kinase, putative 0.0105 0.2965 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0133 0.3929 1
Loa Loa (eye worm) acetyltransferase 0.014 0.4189 0.3985
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0813 0.0968
Onchocerca volvulus 0.0092 0.2535 0.2574
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.027 0.0356
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0034 0.0555 0.0658
Plasmodium falciparum thioredoxin reductase 0.0052 0.1176 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0105 0.2965 0.3976
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.4189 0.4186
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.027 0.1579
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0679 0.1517
Brugia malayi hypothetical protein 0.0262 0.8349 0.8349
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0555 0.0658
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.1273 0.1273
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0796 0.0947
Trypanosoma brucei trypanothione reductase 0.0052 0.1176 0.1574
Schistosoma mansoni hypothetical protein 0.0038 0.0675 0.1156
Schistosoma mansoni kinase 0.0053 0.1203 0.2066
Echinococcus granulosus neuroendocrine convertase 2 0.0111 0.3189 0.3186
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.1176 0.2985
Onchocerca volvulus 0.0053 0.1212 0.0888
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.027 0.2265
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0004 0.0004
Leishmania major hypothetical protein, conserved 0.0028 0.0339 0.0449
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.3064 0.366
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0555 0.0658
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0813 0.0968
Mycobacterium tuberculosis Probable reductase 0.012 0.3473 0.8837
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0515 0.0511
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1117 0.1918
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.027 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0515 0.088
Loa Loa (eye worm) hypothetical protein 0.0262 0.8349 0.8291
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1117 0.1918
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0108 0.3064 0.3061
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1117 0.1114
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.1685 0.2896
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0105 0.2965 0.2962
Schistosoma mansoni hypothetical protein 0.0188 0.5808 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0105 0.2965 0.3121
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.012 0.3473 0.8837
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0555 0.0658
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.1685 0.1682
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0796 0.0947
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0555 0.0658
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0339 0.2855
Mycobacterium ulcerans hypothetical protein 0.0027 0.0312 0.183
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0133 0.3929 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0555 0.0658
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.1156 0.1378
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0515 0.3037
Echinococcus granulosus citrate lyase subunit beta protein 0.0027 0.0312 0.0308
Giardia lamblia Furin precursor putative serine protease 0.0034 0.0555 0.1859
Echinococcus granulosus furin 0.0177 0.544 0.5438
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0473 0.0469
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.2965 0.3976
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.1685 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0796 0.676
Entamoeba histolytica hypothetical protein 0.0035 0.0576 0.1137
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1117 0.1918
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.1685 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.1685 1
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.1156 0.1378
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0108 0.3064 0.3061
Loa Loa (eye worm) hypothetical protein 0.0092 0.2535 0.2274
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0555 0.0658
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0339 0.0449
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0813 0.0968
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.012 0.3473 0.8837
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.1117 0.1117
Echinococcus multilocularis L aminoadipate semialdehyde 0.0092 0.2535 0.2532
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.1176 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0092 0.2535 0.2535
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.027 0.0676
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0339 0.2855
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0177 0.544 0.9366
Trypanosoma cruzi hypothetical protein, conserved 0.0236 0.7449 1
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.027 0.1579
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.027 0.1579
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.027 0.2265
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.027 0.1579
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0515 0.088
Trypanosoma brucei polo-like protein kinase 0.0105 0.2965 0.3976
Entamoeba histolytica hypothetical protein 0.0035 0.0576 0.1137
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.4189 0.4189
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0133 0.3929 1
Loa Loa (eye worm) glutathione reductase 0.0052 0.1176 0.0866
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0231 0.7274 0.7179
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0027 0.0312 0.183
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0027 0.0312 0.183
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0339 0.0449
Entamoeba histolytica hypothetical protein 0.0035 0.0576 0.1137
Echinococcus multilocularis neuroendocrine convertase 2 0.0111 0.3189 0.3186
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0515 0.088
Echinococcus multilocularis 0.0143 0.4268 0.4266
Brugia malayi hypothetical protein 0.0035 0.0576 0.0576
Giardia lamblia High cysteine membrane protein Group 2 0.0066 0.1634 0.5504
Schistosoma mansoni survival motor neuron protein 0.0053 0.1212 0.2081
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0027 0.0312 0.0368
Leishmania major trypanothione reductase 0.0052 0.1176 0.1574
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0105 0.2965 0.2718
Onchocerca volvulus 0.0263 0.8364 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0555 0.0658
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0515 0.088
Plasmodium vivax glutathione reductase, putative 0.0052 0.1176 1
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.1176 0.1574
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.027 1
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0679 0.2278
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0796 0.0792
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.027 1
Brugia malayi endoprotease bli-4 precursor 0.0177 0.544 0.544
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0515 0.0511
Trichomonas vaginalis set domain proteins, putative 0.0263 0.8364 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1117 0.1114
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.1176 0.0866
Mycobacterium ulcerans hypothetical protein 0.0027 0.0312 0.183
Schistosoma mansoni hypothetical protein 0.0053 0.1212 0.2081
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2965 0.3541
Echinococcus multilocularis survival motor neuron protein 1 0.0262 0.8349 0.8348
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.1117 0.0806
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0675 0.0675
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0042 0.0813 0.1394
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.1273 0.1273
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.2965 0.3976
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0034 0.0555 0.0658
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0813 0.0968
Mycobacterium tuberculosis Conserved protein 0.0027 0.0312 0.0784
Echinococcus granulosus geminin 0.0188 0.5808 0.5806
Trypanosoma cruzi hypothetical protein, conserved 0.0236 0.7449 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.012 0.3473 0.8837
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.1273 0.0967
Loa Loa (eye worm) hypothetical protein 0.0177 0.544 0.528
Brugia malayi Thioredoxin reductase 0.0052 0.1176 0.1176
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0576 0.0572
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2965 0.3541
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.027 0.0356
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0027 0.0312 0.0413
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0813 0.0968

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) Reversible competitive inhibition of human furin by Dixon plot ChEMBL. 20038105
Ki (binding) = 1320 nM Inhibition of human furin by fluorescence assay ChEMBL. 20038105

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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