Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Aberrant vpr protein | Starlite/ChEMBL | No references |
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0019 | 0.003 | 0.003 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0072 | 0.336 | 0.336 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0072 | 0.336 | 0.336 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0072 | 0.336 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0072 | 0.336 | 1 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0036 | 0.1116 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0072 | 0.336 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0019 | 0.003 | 0.0266 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0019 | 0.003 | 0.0266 |
Echinococcus multilocularis | pyruvate kinase | 0.0029 | 0.0633 | 0.0633 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0072 | 0.336 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0072 | 0.336 | 1 |
Plasmodium vivax | pyruvate kinase, putative | 0.0036 | 0.1116 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.003 | 0.003 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0036 | 0.1116 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0036 | 0.1116 | 0.5 |
Echinococcus granulosus | pyruvate kinase | 0.0036 | 0.1116 | 0.1116 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0072 | 0.336 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0072 | 0.336 | 1 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0036 | 0.1116 | 0.3261 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0036 | 0.1116 | 0.3261 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.003 | 0.003 |
Schistosoma mansoni | pyruvate kinase | 0.0036 | 0.1116 | 0.1116 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0072 | 0.336 | 0.336 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0025 | 0.0422 | 0.1178 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0036 | 0.1116 | 0.5 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0036 | 0.1116 | 0.3261 |
Loa Loa (eye worm) | pyruvate kinase | 0.0036 | 0.1116 | 0.3261 |
Mycobacterium ulcerans | pyruvate kinase | 0.0036 | 0.1116 | 0.5 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0042 | 0.1449 | 0.1449 |
Schistosoma mansoni | hypothetical protein | 0.0092 | 0.4631 | 0.4631 |
Echinococcus multilocularis | pyruvate kinase | 0.0036 | 0.1116 | 0.1116 |
Echinococcus granulosus | pyruvate kinase | 0.0036 | 0.1116 | 0.1116 |
Leishmania major | pyruvate kinase | 0.0036 | 0.1116 | 0.3261 |
Loa Loa (eye worm) | pyruvate kinase | 0.0036 | 0.1116 | 0.3261 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0036 | 0.1116 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0422 | 0.1178 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0036 | 0.1116 | 0.3261 |
Echinococcus multilocularis | pyruvate kinase | 0.0036 | 0.1116 | 0.1116 |
Leishmania major | pyruvate kinase | 0.0036 | 0.1116 | 0.3261 |
Chlamydia trachomatis | pyruvate kinase | 0.0036 | 0.1116 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.003 | 0.003 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0.003 | 0.0266 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0036 | 0.1116 | 0.5 |
Plasmodium falciparum | pyruvate kinase | 0.0036 | 0.1116 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0.003 | 0.0266 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0036 | 0.1116 | 0.5 |
Giardia lamblia | Pyruvate kinase | 0.0036 | 0.1116 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0019 | 0.003 | 0.003 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0019 | 0.003 | 0.003 |
Loa Loa (eye worm) | pyruvate kinase | 0.0036 | 0.1116 | 0.3261 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.003 | 0.003 |
Schistosoma mansoni | pyruvate kinase | 0.0036 | 0.1116 | 0.1116 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0042 | 0.1449 | 0.1449 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0036 | 0.1116 | 0.3261 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1116 | 0.3261 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0036 | 0.1116 | 0.3261 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0036 | 0.1116 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.