Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 0.2843 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0158 | 0.4717 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 0.2843 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.2843 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0114 | 0.2843 | 0.4937 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.2843 | 0.5 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0114 | 0.2843 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 0.2843 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0158 | 0.4717 | 0.8191 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.4717 | 0.8191 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0053 | 0.02 | 0.0347 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.2843 | 1 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0182 | 0.5758 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.2843 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.3773 | 0.3773 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0053 | 0.02 | 0.0347 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0053 | 0.02 | 0.0347 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 0.2843 | 0.6027 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.2843 | 0.2843 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0114 | 0.2843 | 0.6027 |
Giardia lamblia | Kinase, PLK | 0.0114 | 0.2843 | 0.5 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0053 | 0.02 | 0.02 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0114 | 0.2843 | 0.4937 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.4717 | 0.8191 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.2843 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.02 | 0.0423 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0053 | 0.02 | 0.0347 |
Schistosoma mansoni | kinase | 0.0058 | 0.0433 | 0.0433 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.2843 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.2843 | 1 |
Loa Loa (eye worm) | MBCTL1 | 0.0053 | 0.02 | 0.0423 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.2843 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.2843 | 1 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0053 | 0.02 | 0.0423 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0158 | 0.4717 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.3773 | 0.3773 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0182 | 0.5758 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 30.38 uM | PUBCHEM_BIOASSAY: Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588708, AID588742] | ChEMBL. | No reference |
Potency (functional) | 7.5193 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.7781 uM | PubChem BioAssay. qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 47.4436 uM | PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 67.4555 uM | PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.