TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 309.366 | Formula: C17H19N5O
H donors: 4 H acceptors: 2 LogP: 0.98 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C1NCCc2c1ccc1c2c(CCNCc2c[nH]nc2)c[nH]1
InChi: 1S/C17H19N5O/c23-17-14-1-2-15-16(13(14)4-6-19-17)12(10-20-15)3-5-18-7-11-8-21-22-9-11/h1-2,8-10,18,20H,3-7H2,(H,19,23)(H,21,22)
InChiKey: GBNXZKUIQKSFDY-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	poly (ADP-ribose) polymerase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	poly (adp ribose) polymerase 2	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma japonicum	Poly [ADP-ribose] polymerase 2, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Neospora caninum	hypothetical protein	Get druggable targets OG5_128423	All targets in OG5_128423
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus multilocularis	poly (ADP ribose) polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma japonicum	ko:K00774 NAD ADP-ribosyltransferase [EC2.4.2.30], putative	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus granulosus	WGR domain containing protein	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma japonicum	Poly [ADP-ribose] polymerase 2-A, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus granulosus	poly adp ribose polymerase 2	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus granulosus	poly (ADP ribose) polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus granulosus	poly ADP ribose polymerase 1	Get druggable targets OG5_128423	All targets in OG5_128423
Brugia malayi	WGR domain containing protein	Get druggable targets OG5_128423	All targets in OG5_128423
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma mansoni	poly [ADP-ribose] polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma japonicum	Poly [ADP-ribose] polymerase 1, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Trypanosoma congolense	poly(ADP-ribose) polymerase, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Brugia malayi	WGR domain containing protein	Get druggable targets OG5_128423	All targets in OG5_128423
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma japonicum	Poly [ADP-ribose] polymerase 2, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus granulosus	poly (ADP ribose) polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma mansoni	poly [ADP-ribose] polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Entamoeba histolytica	poly(ADP-ribose) polymerase, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Loa Loa (eye worm)	poly(ADP-ribose) polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma mansoni	poly [ADP-ribose] polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Trypanosoma brucei gambiense	poly(ADP-ribose) polymerase, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma japonicum	Poly [ADP-ribose] polymerase 1, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus granulosus	poly (ADP ribose) polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Trypanosoma brucei	poly(adp-ribose) polymerase	Get druggable targets OG5_128423	All targets in OG5_128423

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0095	0.2504	0.5
Loa Loa (eye worm)	TAR-binding protein	0.0061	0.1254	0.1216
Schistosoma mansoni	hypothetical protein	0.0029	0.0082	0.004
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0402	0.0361
Echinococcus multilocularis	acetylcholinesterase	0.0069	0.1547	0.1511
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1254	0.1216
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Schistosoma mansoni	amine GPCR	0.0029	0.0082	0.004
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Schistosoma mansoni	60S ribosomal protein L21	0.003	0.012	0.0078
Brugia malayi	G protein-coupled receptor	0.0029	0.0082	0.0046
Echinococcus granulosus	g-protein coupled receptor	0.0029	0.0082	0.0082
Brugia malayi	neuropeptide F receptor	0.0029	0.0082	0.0046
Brugia malayi	sulfakinin receptor protein	0.0029	0.0082	0.0046
Echinococcus granulosus	allatostatin A receptor	0.0029	0.0082	0.0082
Echinococcus granulosus	dro:myosuppressin receptor	0.0029	0.0082	0.0082
Echinococcus multilocularis	neuropeptide receptor	0.0029	0.0082	0.004
Echinococcus multilocularis	serotonin receptor	0.0029	0.0082	0.004
Echinococcus granulosus	neuropeptide receptor	0.0029	0.0082	0.0082
Brugia malayi	Carboxylesterase family protein	0.0069	0.1547	0.1745
Echinococcus granulosus	rhodopsin orphan GPCR	0.0029	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Echinococcus granulosus	survival motor neuron protein 1	0.0264	0.8663	0.8663
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0038	0.0402	0.0361
Echinococcus multilocularis	neuropeptide receptor A26	0.0029	0.0082	0.004
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0029	0.0082	0.004
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0029	0.0082	0.004
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0029	0.0082	0.004
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1254	0.1216
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0029	0.0082	0.004
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0054	0.0982	0.1089
Echinococcus granulosus	biogenic amine 5HT receptor	0.0029	0.0082	0.0082
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0029	0.0082	0.004
Loa Loa (eye worm)	neuropeptide F receptor	0.0029	0.0082	0.004
Echinococcus granulosus	acetylcholinesterase	0.0069	0.1547	0.1547
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0029	0.0082	0.004
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.018	0.5616	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0029	0.0082	0.004
Echinococcus granulosus	neuropeptide s receptor	0.0029	0.0082	0.0082
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0029	0.0082	0.004
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0029	0.0082	0.004
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0056	0.1046	0.1165
Echinococcus multilocularis	somatostatin receptor	0.0029	0.0082	0.004
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0029	0.0082	0.004
Echinococcus multilocularis	G protein coupled receptor 139	0.0029	0.0082	0.004
Brugia malayi	G protein-coupled receptor F59B2.13	0.0029	0.0082	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0166	0.5104	0.5083
Entamoeba histolytica	hypothetical protein	0.0035	0.0286	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Echinococcus granulosus	hyperpolarization activated cyclic	0.0038	0.0402	0.0402
Brugia malayi	G-protein coupled receptor	0.0029	0.0082	0.0046
Brugia malayi	ORL1-like opioid receptor	0.0029	0.0082	0.0046
Echinococcus granulosus	poly adp ribose polymerase 2	0.0095	0.2504	0.2504
Schistosoma mansoni	hypothetical protein	0.0054	0.0982	0.0943
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0029	0.0082	0.004
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Echinococcus multilocularis	poly (adp ribose) polymerase 2	0.0095	0.2504	0.2472
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1254	0.1216
Loa Loa (eye worm)	acetylcholinesterase 1	0.0069	0.1547	0.1511
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0038	0.0402	0.0361
Brugia malayi	Serotonin receptor	0.0029	0.0082	0.0046
Schistosoma mansoni	histamine h1 receptor	0.0029	0.0082	0.004
Brugia malayi	putative neuropeptide receptor NPR1	0.0029	0.0082	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Brugia malayi	RE15519p	0.0029	0.0082	0.0046
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0029	0.0082	0.004
Loa Loa (eye worm)	poly(ADP-ribose) polymerase	0.0068	0.1517	0.1481
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0038	0.0402	0.0361
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0029	0.0082	0.004
Schistosoma mansoni	opsin-like receptor	0.0029	0.0082	0.004
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Echinococcus granulosus	rhodopsin orphan GPCR	0.0029	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0029	0.0082	0.004
Schistosoma mansoni	amine GPCR	0.0029	0.0082	0.004
Schistosoma mansoni	hypothetical protein	0.0029	0.0082	0.004
Schistosoma mansoni	biogenic amine receptor	0.0029	0.0082	0.004
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0038	0.0402	0.0402
Echinococcus granulosus	neuropeptides capa receptor	0.0029	0.0082	0.0082
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1254	0.1216
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0029	0.0082	0.0046
Schistosoma mansoni	voltage-gated potassium channel	0.0209	0.6676	0.6661
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0029	0.0082	0.004
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0029	0.0082	0.004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0029	0.0082	0.004
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Schistosoma mansoni	hypothetical protein	0.0035	0.0286	0.0244
Echinococcus multilocularis	g protein coupled receptor	0.0029	0.0082	0.004
Echinococcus granulosus	carboxylesterase 5A	0.0069	0.1547	0.1547
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0029	0.0082	0.004
Echinococcus granulosus	tm gpcr rhodopsin	0.0029	0.0082	0.0082
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0029	0.0082	0.0046
Echinococcus multilocularis	neuropeptide receptor	0.0029	0.0082	0.004
Schistosoma mansoni	adenoreceptor	0.0029	0.0082	0.004
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0029	0.0082	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Brugia malayi	Melatonin receptor type 1A	0.0029	0.0082	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Loa Loa (eye worm)	G-protein coupled receptor	0.0029	0.0082	0.004
Echinococcus granulosus	voltage gated potassium channel	0.0056	0.1046	0.1046
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0029	0.0082	0.004
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0029	0.0082	0.004
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0029	0.0082	0.0082
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0029	0.0082	0.004
Echinococcus granulosus	neuropeptide receptor	0.0029	0.0082	0.0082
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0029	0.0082	0.004
Schistosoma mansoni	amine GPCR	0.0029	0.0082	0.004
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0192	0.6031	0.6014
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0029	0.0082	0.0046
Schistosoma mansoni	neuropeptide F-like receptor	0.0029	0.0082	0.004
Brugia malayi	Serotonin receptor	0.0029	0.0082	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Schistosoma mansoni	survival motor neuron protein	0.0054	0.0982	0.0943
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0029	0.0082	0.004
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0042	0.0042
Entamoeba histolytica	poly(ADP-ribose) polymerase, putative	0.0174	0.5367	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0029	0.0082	0.004
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0179	0.5569	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0029	0.0082	0.004
Brugia malayi	WGR domain containing protein	0.0095	0.2504	0.2855
Echinococcus multilocularis	g protein coupled receptor	0.0029	0.0082	0.004
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0029	0.0082	0.004
Schistosoma mansoni	growth hormone secretagogue receptor	0.0029	0.0082	0.004
Loa Loa (eye worm)	neuropeptide F receptor	0.0029	0.0082	0.004
Schistosoma mansoni	amine GPCR	0.0029	0.0082	0.004
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0029	0.0082	0.004
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0029	0.0082	0.004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0029	0.0082	0.004
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Entamoeba histolytica	hypothetical protein	0.0035	0.0286	0.0532
Echinococcus multilocularis	survival motor neuron protein 1	0.0264	0.8663	0.8658
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Echinococcus granulosus	hyperpolarization activated cyclic	0.0038	0.0402	0.0402
Brugia malayi	hypothetical protein	0.0029	0.0082	0.0046
Trypanosoma brucei	poly(adp-ribose) polymerase	0.0095	0.2504	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0029	0.0082	0.004
Brugia malayi	hypothetical protein	0.0035	0.0286	0.0282
Echinococcus multilocularis	allatostatin A receptor	0.0029	0.0082	0.004
Brugia malayi	hypothetical protein	0.0264	0.8663	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Entamoeba histolytica	hypothetical protein	0.0035	0.0286	0.0532
Echinococcus multilocularis	neuropeptide Y receptor	0.0029	0.0082	0.004
Echinococcus granulosus	rhodopsin orphan GPCR	0.0029	0.0082	0.0082
Echinococcus multilocularis	voltage gated potassium channel	0.0056	0.1046	0.1008
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0029	0.0082	0.0082
Brugia malayi	WGR domain containing protein	0.0174	0.5367	0.6176
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0192	0.6031	0.6014
Brugia malayi	GnHR receptor homolog	0.0029	0.0082	0.0046
Echinococcus granulosus	sex peptide receptor	0.0029	0.0082	0.0082
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0038	0.0402	0.0361
Schistosoma mansoni	hypothetical protein	0.0029	0.0082	0.004
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1046	0.1008
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Brugia malayi	hypothetical protein	0.0029	0.0082	0.0046
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0286	0.0286
Loa Loa (eye worm)	TYRA-2 protein	0.0029	0.0082	0.004
Echinococcus granulosus	neuropeptide Y receptor	0.0029	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Entamoeba histolytica	hypothetical protein	0.0035	0.0286	0.0532
Schistosoma mansoni	voltage-gated potassium channel	0.0056	0.1046	0.1008
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0029	0.0082	0.004
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0038	0.0402	0.0361
Echinococcus granulosus	rhodopsin orphan GPCR	0.0029	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2504	0.2472
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0038	0.0402	0.0361
Onchocerca volvulus		0.0054	0.0982	1
Brugia malayi	Dopamine receptor	0.0029	0.0082	0.0046
Echinococcus multilocularis	neuropeptides capa receptor	0.0029	0.0082	0.004
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	0.0174	0.5367	0.5347
Brugia malayi	Dopamine receptor protein 1	0.0029	0.0082	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0061	0.1254	0.1216
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Echinococcus granulosus	somatostatin receptor	0.0029	0.0082	0.0082
Brugia malayi	Dopamine receptor protein 2	0.0029	0.0082	0.0046
Schistosoma mansoni	amine GPCR	0.0029	0.0082	0.004
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0029	0.0082	0.004
Echinococcus multilocularis	poly (ADP ribose) polymerase	0.004	0.0471	0.0431
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Schistosoma mansoni	voltage-gated potassium channel	0.0038	0.0402	0.0361
Echinococcus granulosus	acetylcholinesterase	0.0069	0.1547	0.1547
Echinococcus multilocularis	dro:myosuppressin receptor	0.0029	0.0082	0.004
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0095	0.2504	0.5
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0038	0.0402	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0192	0.6031	0.6031
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0029	0.0082	0.004
Echinococcus multilocularis	g protein coupled receptor	0.0029	0.0082	0.004
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0029	0.0082	0.0082
Echinococcus granulosus	biogenic amine 5HT receptor	0.0029	0.0082	0.0082
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1254	0.1216
Brugia malayi	AKH receptor	0.0029	0.0082	0.0046
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0286	0.0244
Echinococcus multilocularis	sex peptide receptor	0.0029	0.0082	0.004
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0029	0.0082	0.0082
Brugia malayi	TAR-binding protein	0.0061	0.1254	0.1405
Schistosoma mansoni	biogenic amine receptor	0.0029	0.0082	0.004
Echinococcus granulosus	poly ADP ribose polymerase 1	0.0174	0.5367	0.5367
Brugia malayi	Carboxylesterase family protein	0.0069	0.1547	0.1745
Schistosoma mansoni	myosin xvIII	0.0029	0.0082	0.004
Echinococcus granulosus	orexin receptor type 2	0.0029	0.0082	0.0082
Echinococcus multilocularis	serotonin receptor	0.0029	0.0082	0.004
Schistosoma mansoni	opsin-like receptor	0.0029	0.0082	0.004
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0038	0.0402	0.0361
Schistosoma mansoni	neuropeptide F-like receptor	0.0029	0.0082	0.004
Echinococcus multilocularis	g-protein coupled receptor	0.0029	0.0082	0.004
Brugia malayi	RNA recognition motif domain containing protein	0.0061	0.1254	0.1405
Echinococcus granulosus	g protein coupled receptor	0.0029	0.0082	0.0082
Brugia malayi	hypothetical protein	0.0029	0.0082	0.0046
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0056	0.1046	0.1008
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Brugia malayi	RNA, U transporter 1	0.008	0.194	0.2201
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0029	0.0082	0.004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0029	0.0082	0.004
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0038	0.0402	0.0417
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0192	0.6031	0.6946
Schistosoma mansoni	hypothetical protein	0.0029	0.0082	0.004
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0029	0.0082	0.0046
Brugia malayi	hypothetical protein	0.0029	0.0082	0.0046
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0029	0.0082	0.0082
Brugia malayi	putative neuropeptide receptor	0.0029	0.0082	0.0046
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0029	0.0082	0.004
Schistosoma mansoni	voltage-gated potassium channel	0.0209	0.6676	0.6661
Plasmodium falciparum	importin beta, putative	0.0028	0.0042	0.5
Brugia malayi	G-protein coupled receptor	0.0029	0.0082	0.0046
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0029	0.0082	0.004
Schistosoma mansoni	neuropeptide receptor	0.0029	0.0082	0.004
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0029	0.0082	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Echinococcus multilocularis	acetylcholinesterase	0.0069	0.1547	0.1511
Echinococcus granulosus	rhodopsin orphan GPCR	0.0029	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0038	0.0402	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0029	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1547	0.1511
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0042	0.5
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0179	0.5569	1
Echinococcus granulosus	tar DNA binding protein	0.0061	0.1254	0.1254
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0029	0.0082	0.004
Loa Loa (eye worm)	melatonin receptor type 1A	0.0029	0.0082	0.004
Brugia malayi	hypothetical protein	0.0029	0.0082	0.0046
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0029	0.0082	0.004
Echinococcus granulosus	hypothetical protein	0.0029	0.0082	0.0082
Schistosoma mansoni	biogenic amine receptor	0.0029	0.0082	0.004
Brugia malayi	hypothetical protein	0.0029	0.0082	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Echinococcus granulosus	rhodopsin orphan GPCR	0.0029	0.0082	0.0082
Schistosoma mansoni	opsin-like receptor	0.0029	0.0082	0.004
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0029	0.0082	0.004
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0029	0.0082	0.0082
Echinococcus multilocularis	carboxylesterase 5A	0.0069	0.1547	0.1511
Echinococcus granulosus	G protein coupled receptor 139	0.0029	0.0082	0.0082
Schistosoma mansoni	voltage-gated potassium channel	0.0056	0.1046	0.1008
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0029	0.0082	0.004
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0038	0.0402	0.0361
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0038	0.0402	0.0361
Brugia malayi	neuropeptide F receptor	0.0029	0.0082	0.0046
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0038	0.0402	0.0361
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0038	0.0402	0.0361
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0174	0.5367	0.5347
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0029	0.0082	0.004
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Echinococcus granulosus	fmrfamide receptor	0.0029	0.0082	0.0082
Echinococcus multilocularis	fmrfamide receptor	0.0029	0.0082	0.004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0029	0.0082	0.004
Brugia malayi	larval opioid receptor	0.0029	0.0082	0.0046
Brugia malayi	hypothetical protein	0.0029	0.0082	0.0046
Echinococcus granulosus	neuropeptide Y receptor	0.0029	0.0082	0.0082
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0069	0.1547	0.1511
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0286	0.0244
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0054	0.0987	0.0987
Echinococcus granulosus	WGR domain containing protein	0.0054	0.0987	0.0987
Loa Loa (eye worm)	RNA binding protein	0.0061	0.1254	0.1216
Echinococcus multilocularis	fmrfamide receptor	0.0029	0.0082	0.004
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0029	0.0082	0.0082
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0029	0.0082	0.004
Loa Loa (eye worm)	carboxylesterase	0.0069	0.1547	0.1511
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Echinococcus granulosus	g protein coupled receptor	0.0029	0.0082	0.0082
Echinococcus granulosus	7tm_1 domain containing protein	0.0029	0.0082	0.0082
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0082	0.2033	0.1999
Echinococcus multilocularis	tar DNA binding protein	0.0061	0.1254	0.1216
Echinococcus multilocularis	neuropeptides capa receptor	0.0029	0.0082	0.004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0029	0.0082	0.004
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0029	0.0082	0.004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0029	0.0082	0.004
Schistosoma mansoni	neuropeptide receptor	0.0029	0.0082	0.004
Schistosoma mansoni	voltage-gated potassium channel	0.003	0.012	0.0078
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0095	0.2504	0.2472
Echinococcus multilocularis	orexin receptor type 2	0.0029	0.0082	0.004
Schistosoma mansoni	neuropeptide f receptor 76f	0.0029	0.0082	0.004
Loa Loa (eye worm)	G-protein coupled receptor	0.0029	0.0082	0.004
Brugia malayi	hypothetical protein	0.0029	0.0082	0.0046
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0056	0.1046	0.1046
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0029	0.0082	0.004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0029	0.0082	0.004
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0038	0.0402	0.0402
Echinococcus granulosus	rhodopsin orphan GPCR	0.0029	0.0082	0.0082
Echinococcus granulosus	g protein coupled receptor	0.0029	0.0082	0.0082
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0029	0.0082	0.004
Echinococcus granulosus	neuropeptide receptor A26	0.0029	0.0082	0.0082
Schistosoma mansoni	neuropeptide receptor	0.0029	0.0082	0.004
Echinococcus granulosus	neuropeptide FF receptor 2	0.0029	0.0082	0.0082
Echinococcus granulosus	neuropeptides capa receptor	0.0029	0.0082	0.0082
Brugia malayi	RNA binding protein	0.0061	0.1254	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0029	0.0082	0.004
Echinococcus granulosus	tm gpcr rhodopsin	0.0029	0.0082	0.0082
Brugia malayi	follicle stimulating hormone receptor	0.0029	0.0082	0.0046
Brugia malayi	hypothetical protein	0.0029	0.0082	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0264	0.8663	0.8658
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0029	0.0082	0.0082
Echinococcus multilocularis	neuropeptide s receptor	0.0029	0.0082	0.004
Brugia malayi	hypothetical protein	0.0029	0.0082	0.0046
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0029	0.0082	0.004
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0029	0.0082	0.004
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.004
Echinococcus granulosus	7TM GPCR rhodopsin	0.0029	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0132	0.385	0.3824
Echinococcus granulosus	tm gpcr rhodopsin	0.0029	0.0082	0.0082
Echinococcus granulosus	serotonin receptor	0.0029	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1547	0.1511
Echinococcus multilocularis	neuropeptide Y receptor	0.0029	0.0082	0.004
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0038	0.0402	0.0402
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0029	0.0082	0.004
Schistosoma mansoni	neuropeptide receptor	0.0029	0.0082	0.004

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 340 nM	Inhibition of PARP1 in human HeLa cells by microplate scintillation counting	ChEMBL.	19553107

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL569363

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1069047