Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0017 | 0.0383 | 0.3372 | |
Brugia malayi | Cathepsin L-like precursor | 0.0011 | 0.0031 | 0.0033 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0109 | 0.6118 | 0.8837 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0016 | 0.0292 | 0.0312 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.3373 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0017 | 0.0383 | 0.0383 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0048 | 0.2299 | 0.2299 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0017 | 0.0352 | 0.0352 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.2142 | 0.2282 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0017 | 0.0383 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.3963 | 1 |
Leishmania major | cathepsin L-like protease | 0.0017 | 0.0383 | 0.0104 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0383 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.3373 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0383 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0162 | 0.9385 | 0.9385 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0048 | 0.2299 | 0.6446 |
Onchocerca volvulus | 0.0017 | 0.0383 | 0.3372 | |
Leishmania major | cathepsin L-like protease | 0.0017 | 0.0383 | 0.0104 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0031 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.9385 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0014 | 0.0196 | 0.0196 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0017 | 0.0352 | 0.911 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2142 | 0.2142 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.1136 | 0.1136 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0017 | 0.0383 | 0.0104 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0048 | 0.2299 | 1 |
Plasmodium vivax | vivapain-2 | 0.0017 | 0.0383 | 0.0161 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0163 | 0.0173 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1103 | 0.1175 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0031 | 0.0033 |
Onchocerca volvulus | 0.0017 | 0.0383 | 0.3372 | |
Echinococcus multilocularis | lamin | 0.0029 | 0.1136 | 0.1136 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0017 | 0.0383 | 0.0383 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.3963 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.1136 | 0.1211 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0075 | 0.3963 | 0.3963 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0383 | 1 |
Leishmania major | cathepsin L-like protease | 0.0017 | 0.0383 | 0.0104 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0383 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0109 | 0.6118 | 0.8837 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0383 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.2142 | 0.2282 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0383 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0122 | 0.6877 | 1 |
Echinococcus granulosus | lamin | 0.0029 | 0.1136 | 0.1136 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0017 | 0.0383 | 0.0161 |
Brugia malayi | Thioredoxin reductase | 0.0048 | 0.2299 | 0.245 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0017 | 0.0352 | 0.0375 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.2142 | 0.2142 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.3963 | 0.3963 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0109 | 0.6118 | 0.8837 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0017 | 0.0383 | 0.0383 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0162 | 0.9385 | 0.9385 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.3963 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0383 | 1 |
Brugia malayi | hypothetical protein | 0.0075 | 0.3963 | 0.4223 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0017 | 0.0352 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0017 | 0.0352 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0383 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0383 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0048 | 0.2299 | 0.245 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.3373 | 1 |
Onchocerca volvulus | 0.0017 | 0.0383 | 0.3372 | |
Trypanosoma brucei | trypanothione reductase | 0.0048 | 0.2299 | 0.6446 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0109 | 0.6118 | 0.8837 |
Onchocerca volvulus | 0.0011 | 0.0031 | 0.0276 | |
Leishmania major | cathepsin L-like protease | 0.0065 | 0.3373 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.2142 | 0.2142 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2142 | 0.2142 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.2142 | 0.2142 |
Loa Loa (eye worm) | cysteine protease | 0.0017 | 0.0383 | 0.0408 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0017 | 0.0352 | 0.911 |
Echinococcus granulosus | cathepsin l1 | 0.0017 | 0.0383 | 0.0383 |
Onchocerca volvulus | 0.0017 | 0.0383 | 0.3372 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0383 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0065 | 0.3373 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0383 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0017 | 0.0383 | 0.3372 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.1136 | 0.1211 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0017 | 0.0383 | 0.0895 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0122 | 0.6877 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0017 | 0.0383 | 0.0383 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0048 | 0.2299 | 0.2299 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0196 | 0.0209 |
Echinococcus granulosus | cathepsin l1 | 0.0011 | 0.0031 | 0.0031 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0075 | 0.3963 | 0.3963 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0017 | 0.0383 | 0.0895 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0163 | 0.0173 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0383 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0383 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0048 | 0.2299 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0075 | 0.3963 | 0.3963 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.006 | 0.3022 | 0.8836 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.3373 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0162 | 0.9385 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0292 | 0.0312 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.2142 | 0.2142 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.3373 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.3373 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0162 | 0.9385 | 0.9385 |
Plasmodium falciparum | thioredoxin reductase | 0.0048 | 0.2299 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0383 | 0.0408 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0.0352 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0048 | 0.2299 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0383 | 0.0408 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0383 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0017 | 0.0383 | 0.0408 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0383 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0017 | 0.0352 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0065 | 0.3373 | 1 |
Plasmodium vivax | vivapain-2 | 0.0017 | 0.0383 | 0.0161 |
Schistosoma mansoni | lamin | 0.0029 | 0.1136 | 0.1136 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0065 | 0.3373 | 1 |
Treponema pallidum | NADH oxidase | 0.0017 | 0.0352 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.3373 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0017 | 0.0383 | 0.0408 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0017 | 0.0383 | 0.0383 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0017 | 0.0383 | 0.0408 |
Brugia malayi | glutathione reductase | 0.0048 | 0.2299 | 0.245 |
Onchocerca volvulus | 0.0029 | 0.1136 | 1 | |
Schistosoma mansoni | lamin | 0.0029 | 0.1136 | 0.1136 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0383 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2142 | 0.2142 |
Toxoplasma gondii | cathepsin CPL | 0.0017 | 0.0383 | 0.0161 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0017 | 0.0352 | 0.0352 |
Echinococcus multilocularis | cysteine protease | 0.0017 | 0.0383 | 0.0383 |
Loa Loa (eye worm) | glutathione reductase | 0.0048 | 0.2299 | 0.245 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0383 | 0.0408 |
Onchocerca volvulus | 0.0029 | 0.1136 | 1 | |
Echinococcus multilocularis | musashi | 0.0029 | 0.1136 | 0.1136 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0109 | 0.6118 | 0.8837 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.1136 | 0.1211 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.3373 | 1 |
Leishmania major | cathepsin L-like protease | 0.0017 | 0.0383 | 0.0104 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0017 | 0.0383 | 0.0383 |
Loa Loa (eye worm) | fibroinase | 0.0017 | 0.0383 | 0.0408 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0017 | 0.0383 | 0.0161 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.3963 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0017 | 0.0383 | 0.0895 |
Leishmania major | cysteine peptidase A (CPA) | 0.0017 | 0.0383 | 0.0104 |
Leishmania major | trypanothione reductase | 0.0048 | 0.2299 | 0.6446 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0017 | 0.0383 | 0.0383 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0048 | 0.2299 | 0.2985 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0383 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0383 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.3373 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0.0352 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0031 | 0.0033 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0383 | 0.0408 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1136 | 0.1211 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0051 | 0.2506 | 0.7128 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0383 | 0.0408 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0011 | 0.0031 | 0.0031 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0383 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0122 | 0.6877 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0065 | 0.3373 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0122 | 0.6877 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0017 | 0.0352 | 0.5 |
Brugia malayi | cathepsin L-like precursor | 0.0011 | 0.0031 | 0.0033 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.1136 | 0.1211 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0012 | 0.0078 | 0.0083 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0383 | 0.0408 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0012 | 0.0078 | 0.0083 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0383 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0014 | 0.0196 | 0.0196 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0011 | 0.0031 | 0.0033 |
Leishmania major | cathepsin L-like protease | 0.0017 | 0.0383 | 0.0104 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0383 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.1136 | 0.1136 |
Leishmania major | cathepsin L-like protease | 0.0065 | 0.3373 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0017 | 0.0383 | 0.0161 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.1136 | 0.1136 |
Brugia malayi | Cathepsin L-like precursor | 0.0011 | 0.0031 | 0.0033 |
Toxoplasma gondii | thioredoxin reductase | 0.0048 | 0.2299 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0383 | 0.0408 |
Onchocerca volvulus | 0.0017 | 0.0383 | 0.3372 | |
Echinococcus multilocularis | cysteine protease | 0.0017 | 0.0383 | 0.0383 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0383 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0017 | 0.0383 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.3373 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0109 | 0.6118 | 0.8837 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.9385 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.1136 | 0.1136 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0065 | 0.3373 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0017 | 0.0383 | 0.0383 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.3373 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0017 | 0.0383 | 0.3372 |
Onchocerca volvulus | Cathepsin L homolog | 0.0017 | 0.0383 | 0.3372 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0383 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0017 | 0.0352 | 0.5 |
Onchocerca volvulus | 0.0017 | 0.0383 | 0.3372 | |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0017 | 0.0352 | 0.0352 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0017 | 0.0383 | 0.0408 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 27 uM | Inhibition of Leishmania major recombinant PTR1 | ChEMBL. | 19916554 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.