TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 545.115 | Formula: C32H37ClN4O2
H donors: 1 H acceptors: 2 LogP: 5.93 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: Clc1ccc(cc1)c1c(=O)n(CCCCN2CCC(CC2)c2c(C)[nH]c3c2cccc3)c(=O)n2c1CCCC2
InChi: 1S/C32H37ClN4O2/c1-22-29(26-8-2-3-9-27(26)34-22)24-15-20-35(21-16-24)17-6-7-19-37-31(38)30(23-11-13-25(33)14-12-23)28-10-4-5-18-36(28)32(37)39/h2-3,8-9,11-14,24,34H,4-7,10,15-21H2,1H3
InChiKey: IYDRIXUPUQQGSF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Serotonin 1a (5-HT1a) receptor	Starlite/ChEMBL	References
Rattus norvegicus	Serotonin transporter	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Sodium:neurotransmitter symporter family protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus granulosus	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133249	All targets in OG5_133249
Loa Loa (eye worm)	norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	sodium/chloride dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Onchocerca volvulus		Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Octopamine receptor, putative	Get druggable targets OG5_133249	All targets in OG5_133249
Echinococcus granulosus	biogenic amine 5HT receptor	Get druggable targets OG5_133249	All targets in OG5_133249
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	biogenic amine (5HT) receptor	Get druggable targets OG5_133249	All targets in OG5_133249
Echinococcus multilocularis	serotonin receptor	Get druggable targets OG5_133249	All targets in OG5_133249
Echinococcus multilocularis	serotonin receptor	Get druggable targets OG5_133249	All targets in OG5_133249
Loa Loa (eye worm)	solute carrier family 6 member 4	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133249	All targets in OG5_133249
Schistosoma japonicum	ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus multilocularis	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Treponema pallidum	sodium- and chloride- dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	IPR000175,Sodium:neurotransmitter symporter,domain-containing	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	serotonin transporter b	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative	Get druggable targets OG5_133249	All targets in OG5_133249
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent noradrenaline transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	expressed protein	Get druggable targets OG5_133249	All targets in OG5_133249
Schistosoma mansoni	norepinephrine/norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	Serotonin 1a (5-HT1a) receptor	422 aa	350 aa	20.6 %
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Serotonin 1a (5-HT1a) receptor	422 aa	417 aa	21.1 %
Onchocerca volvulus		Serotonin transporter	630 aa	611 aa	26.4 %
Echinococcus multilocularis	orexin receptor type 2	Serotonin 1a (5-HT1a) receptor	422 aa	369 aa	22.2 %
Onchocerca volvulus		Serotonin 1a (5-HT1a) receptor	422 aa	426 aa	29.6 %
Onchocerca volvulus		Serotonin 1a (5-HT1a) receptor	422 aa	390 aa	33.6 %
Onchocerca volvulus	High affinity copper uptake protein 1 homolog	Serotonin transporter	630 aa	629 aa	47.1 %
Schistosoma japonicum	ko:K04207 neuropeptide Y receptor Y5, putative	Serotonin 1a (5-HT1a) receptor	422 aa	339 aa	23.0 %
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	Serotonin transporter	630 aa	582 aa	35.2 %
Schistosoma mansoni	sodium/chloride dependent transporter	Serotonin transporter	630 aa	605 aa	37.7 %
Plasmodium vivax	hypothetical protein, conserved	Serotonin transporter	630 aa	528 aa	21.2 %
Loa Loa (eye worm)	TYRA-2 protein	Serotonin 1a (5-HT1a) receptor	422 aa	491 aa	27.3 %
Plasmodium knowlesi	transporter, putative	Serotonin transporter	630 aa	514 aa	20.2 %
Echinococcus multilocularis	g protein coupled receptor	Serotonin 1a (5-HT1a) receptor	422 aa	432 aa	23.6 %
Echinococcus granulosus	alpha 1A adrenergic receptor	Serotonin 1a (5-HT1a) receptor	422 aa	452 aa	21.0 %
Onchocerca volvulus	Transmembrane protein 120 homolog	Serotonin transporter	630 aa	571 aa	31.2 %
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Serotonin 1a (5-HT1a) receptor	422 aa	392 aa	20.7 %
Echinococcus multilocularis	sodium and chloride dependent glycine	Serotonin transporter	630 aa	617 aa	39.4 %
Echinococcus granulosus	orexin receptor type 2	Serotonin 1a (5-HT1a) receptor	422 aa	369 aa	22.0 %
Onchocerca volvulus	Mitochondrial inner membrane protein homolog	Serotonin 1a (5-HT1a) receptor	422 aa	383 aa	30.5 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Serotonin 1a (5-HT1a) receptor	422 aa	448 aa	29.7 %
Drosophila melanogaster	CG13796 gene product from transcript CG13796-RD	Serotonin transporter	630 aa	638 aa	25.1 %
Onchocerca volvulus		Serotonin 1a (5-HT1a) receptor	422 aa	436 aa	23.9 %
Echinococcus granulosus	g protein coupled receptor	Serotonin 1a (5-HT1a) receptor	422 aa	432 aa	24.3 %
Echinococcus granulosus	g protein coupled receptor	Serotonin 1a (5-HT1a) receptor	422 aa	432 aa	23.4 %
Drosophila melanogaster	CG1698 gene product from transcript CG1698-RA	Serotonin transporter	630 aa	585 aa	34.2 %
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	Serotonin transporter	630 aa	509 aa	28.3 %
Schistosoma japonicum	ko:K04136 adrenergic receptor, alpha 1b, putative	Serotonin 1a (5-HT1a) receptor	422 aa	444 aa	29.3 %
Echinococcus multilocularis	g protein coupled receptor	Serotonin 1a (5-HT1a) receptor	422 aa	433 aa	22.4 %
Loa Loa (eye worm)	hypothetical protein	Serotonin 1a (5-HT1a) receptor	422 aa	388 aa	26.5 %
Onchocerca volvulus	Glycoprotein hormone beta 5 homolog	Serotonin 1a (5-HT1a) receptor	422 aa	477 aa	24.3 %
Brugia malayi	Sodium:neurotransmitter symporter family protein	Serotonin transporter	630 aa	576 aa	30.9 %
Onchocerca volvulus		Serotonin 1a (5-HT1a) receptor	422 aa	407 aa	23.3 %
Schistosoma japonicum	Octopamine receptor 1, putative	Serotonin 1a (5-HT1a) receptor	422 aa	424 aa	24.3 %
Schistosoma japonicum	ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative	Serotonin transporter	630 aa	520 aa	36.2 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Serotonin 1a (5-HT1a) receptor	422 aa	410 aa	27.8 %
Schistosoma mansoni	sodium/chloride dependent transporter	Serotonin transporter	630 aa	552 aa	41.5 %
Schistosoma mansoni	amine GPCR	Serotonin 1a (5-HT1a) receptor	422 aa	440 aa	31.6 %
Echinococcus multilocularis	neuropeptides capa receptor	Serotonin 1a (5-HT1a) receptor	422 aa	430 aa	20.0 %
Schistosoma japonicum	ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative	Serotonin transporter	630 aa	581 aa	40.1 %
Echinococcus granulosus	sodium and chloride dependent glycine	Serotonin transporter	630 aa	617 aa	39.4 %
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	Serotonin transporter	630 aa	576 aa	31.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	smad1 5 8 and	0.0076	0.0131	0.0131
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0128	0.0254	0.0254
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0031	0.0132
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0153	0.0312	1
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0031	0.0121
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0039	0.0045	0.0045
Echinococcus granulosus	cathepsin l1	0.0022	0.0005	0.0005
Onchocerca volvulus		0.004	0.0047	0.018
Schistosoma mansoni	intermediate filament proteins	0.0085	0.0152	0.0152
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0036	0.0154
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.0061	0.0096	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0005	0.0022
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0022	0.0005	0.002
Echinococcus granulosus	lamin	0.0085	0.0152	0.0152
Schistosoma mansoni	ferritin	0.0061	0.0096	0.0096
Schistosoma mansoni	tar DNA-binding protein	0.0198	0.0417	0.0417
Toxoplasma gondii	ABC1 family protein	0.004	0.0047	0.1515
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0044	0.0057	0.0223
Schistosoma mansoni	Smad4	0.0034	0.0033	0.0033
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0033	0.0031	1
Leishmania major	hypothetical protein, conserved	0.004	0.0047	0.1894
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0093	0.299
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0314	0.0688	1
Schistosoma mansoni	apoferritin-2	0.0061	0.0096	0.0096
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0033	0.0031	0.0132
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0032	0.0029	0.0029
Onchocerca volvulus		0.004	0.0047	0.018
Onchocerca volvulus		0.0085	0.0152	0.0628
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0049	0.0068	0.0068
Echinococcus multilocularis	tumor protein p63	0.2765	0.6431	0.6431
Onchocerca volvulus	Cathepsin L homolog	0.0033	0.0031	0.011
Loa Loa (eye worm)	hypothetical protein	0.004	0.0047	0.0184
Onchocerca volvulus		0.0033	0.0031	0.011
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.004	0.0047	0.0184
Brugia malayi	latrophilin 2 splice variant baaae	0.0353	0.078	0.3042
Echinococcus granulosus	lysine specific demethylase 5A	0.0039	0.0045	0.0045
Brugia malayi	MH2 domain containing protein	0.0076	0.0131	0.0511
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.0093	0.0093
Trypanosoma cruzi	major cysteine proteinase, putative	0.01	0.0186	0.7458
Loa Loa (eye worm)	MH2 domain-containing protein	0.0034	0.0033	0.0127
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.004	0.0047	0.0852
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0045	0.0177
Loa Loa (eye worm)	Smad1	0.0076	0.0131	0.0511
Echinococcus multilocularis	jumonji domain containing protein	0.0045	0.0059	0.0059
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0041	0.0049	0.0049
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0031	0.0121
Mycobacterium tuberculosis	Conserved protein	0.004	0.0047	0.0852
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0009	0.0039
Brugia malayi	MH1 domain containing protein	0.0076	0.0131	0.0511
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0314	0.0688	0.294
Echinococcus granulosus	intermediate filament protein	0.0085	0.0152	0.0152
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0085	0.0152	0.0592
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0314	0.0688	0.294
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0049	0.0068	0.0068
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0042	0.018
Trypanosoma cruzi	cysteine peptidase, putative	0.0033	0.0031	0.1239
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0005	0.002
Echinococcus granulosus	peregrin	0.0032	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.004	0.0047	0.0184
Brugia malayi	cathepsin L-like precursor	0.0022	0.0005	0.002
Loa Loa (eye worm)	jmjC domain-containing protein	0.0067	0.011	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0124	0.0484
Onchocerca volvulus	Cathepsin F homolog	0.0033	0.0031	0.011
Echinococcus granulosus	lamin dm0	0.0085	0.0152	0.0152
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.025	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.025	1
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0047	0.1515
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0009	0.004
Loa Loa (eye worm)	hypothetical protein	0.0024	0.001	0.0041
Schistosoma mansoni	Smad4	0.0034	0.0033	0.0033
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0031	0.0132
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0093	0.0093
Brugia malayi	MH2 domain containing protein	0.0034	0.0033	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0405	0.0901	0.3514
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0068	0.029
Brugia malayi	Latrophilin receptor protein 2	0.0163	0.0336	0.131
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0049	0.0068	0.2712
Echinococcus multilocularis	smad	0.0076	0.0131	0.0131
Trichomonas vaginalis	set domain proteins, putative	0.1018	0.2339	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0128	0.0254	0.0254
Loa Loa (eye worm)	phosphatidylinositol 3	0.0044	0.0057	0.0223
Leishmania major	cathepsin L-like protease	0.0033	0.0031	0.1239
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0015	0.0065
Onchocerca volvulus		0.0073	0.0124	0.0509
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0044	0.0057	0.0057
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0314	0.0688	0.294
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0516	0.1163	0.4534
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0005	0.002
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0314	0.0688	1
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0049	0.0068	0.2712
Brugia malayi	Pre-SET motif family protein	0.0128	0.0254	0.0989
Echinococcus multilocularis	serotonin transporter	0.0073	0.0124	0.0124
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.025	1
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0005	0.002
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0031	0.0132
Brugia malayi	MH1 domain containing protein	0.0076	0.0131	0.0511
Echinococcus granulosus	ferritin	0.0061	0.0096	0.0096
Brugia malayi	MH2 domain containing protein	0.1115	0.2565	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0033	0.0031	0.0031
Mycobacterium tuberculosis	Probable bacterioferritin BfrA	0.0061	0.0096	0.1722
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0031	0.0132
Schistosoma mansoni	ferritin light chain	0.0061	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.015	0.0304	0.1186
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0093	0.0093
Schistosoma mansoni	ferritin	0.0061	0.0096	0.0096
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0031	0.0132
Echinococcus multilocularis	ferritin	0.0061	0.0096	0.0096
Schistosoma mansoni	ferritin	0.0061	0.0096	0.0096
Loa Loa (eye worm)	jmjC domain-containing protein	0.0039	0.0045	0.0175
Onchocerca volvulus		0.0128	0.0254	0.1065
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0128	0.0254	0.0254
Echinococcus granulosus	GPCR family 2	0.0163	0.0336	0.0336
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0047	0.0202
Mycobacterium tuberculosis	Probable hydrolase	0.004	0.0047	0.0852
Schistosoma mansoni	smad1 5 8 and	0.0076	0.0131	0.0131
Brugia malayi	intermediate filament protein	0.0085	0.0152	0.0592
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0076	0.0131	0.0131
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0036	0.0154
Giardia lamblia	Fructose-bisphosphate aldolase	0.0314	0.0688	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0031	0.0131
Echinococcus granulosus	PHD finger protein rhinoceros	0.0032	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0049	0.0191
Echinococcus multilocularis	lamin	0.0085	0.0152	0.0152
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0044	0.0057	0.2291
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0148	0.0578
Brugia malayi	TAR-binding protein	0.0198	0.0417	0.1625
Loa Loa (eye worm)	RNA binding protein	0.0198	0.0417	0.1625
Schistosoma mansoni	cathepsin F (C01 family)	0.0033	0.0031	0.0031
Mycobacterium tuberculosis	Probable esterase LipL	0.004	0.0047	0.0852
Onchocerca volvulus		0.0033	0.0031	0.011
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0128	0.0254	0.0254
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.004	0.0047	0.0852
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0005	0.002
Treponema pallidum	fructose-bisphosphate aldolase	0.0314	0.0688	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0033	0.0031	0.0132
Schistosoma mansoni	jumonji domain containing protein	0.0084	0.0151	0.0151
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0033	0.0031	0.0031
Onchocerca volvulus	Cathepsin L homolog	0.0033	0.0031	0.011
Onchocerca volvulus		0.0033	0.0031	0.011
Loa Loa (eye worm)	hypothetical protein	0.0163	0.0336	0.131
Plasmodium vivax	hypothetical protein, conserved	0.0032	0.0029	0.0762
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0047	0.0047
Onchocerca volvulus	Alhambra homolog	0.0032	0.0029	0.0102
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0015	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0033	0.0127
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0033	0.0031	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0127	0.025	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0052	0.0201
Loa Loa (eye worm)	MH2 domain-containing protein	0.1115	0.2565	1
Echinococcus granulosus	jumonji domain containing protein	0.0045	0.0059	0.0059
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.025	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0047	0.0184
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0153	0.0312	0.5619
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0031	0.0132
Schistosoma mansoni	tar DNA-binding protein	0.0198	0.0417	0.0417
Mycobacterium ulcerans	esterase/lipase LipP	0.004	0.0047	0.1517
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.025	1
Leishmania major	cathepsin L-like protease	0.0127	0.025	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0124	0.0243	0.0243
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0033	0.0031	0.0121
Brugia malayi	PHD-finger family protein	0.0032	0.0029	0.0113
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0073	0.0124	0.0124
Trichomonas vaginalis	esterase, putative	0.004	0.0047	0.0202
Brugia malayi	hypothetical protein	0.0024	0.001	0.0041
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0049	0.0068	0.0985
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0031	0.0121
Mycobacterium tuberculosis	Probable lipase LipE	0.004	0.0047	0.0852
Brugia malayi	RNA recognition motif domain containing protein	0.0198	0.0417	0.1625
Echinococcus multilocularis	Smad4	0.0076	0.0131	0.0131
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0057	0.0245
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0032	0.0029	0.0029
Echinococcus multilocularis	tar DNA binding protein	0.0198	0.0417	0.0417
Leishmania major	cathepsin L-like protease	0.0127	0.025	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0036	0.0154
Mycobacterium tuberculosis	Conserved protein	0.004	0.0047	0.0852
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0031	0.0132
Echinococcus granulosus	beta LACTamase domain containing family member	0.004	0.0047	0.0047
Mycobacterium ulcerans	bacterioferritin BfrB	0.0061	0.0096	0.3064
Mycobacterium leprae	PROBABLE BACTERIOFERRITIN BFRA	0.0061	0.0096	0.1824
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0153	0.0312	1
Onchocerca volvulus		0.0033	0.0031	0.011
Trichomonas vaginalis	ferritin, putative	0.0061	0.0096	0.0409
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0128	0.0254	0.0254
Loa Loa (eye worm)	MH2 domain-containing protein	0.0076	0.0131	0.0511
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0031	0.0131
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0049	0.0068	0.0068
Mycobacterium ulcerans	bacterioferritin BfrA	0.0061	0.0096	0.3064
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0031	0.0132
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0005	0.0022
Mycobacterium tuberculosis	Probable lipase LipD	0.004	0.0047	0.0852
Echinococcus multilocularis	peregrin	0.0032	0.0029	0.0029
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.025	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0031	0.0132
Loa Loa (eye worm)	beta-lactamase	0.004	0.0047	0.0184
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0033	0.0031	1
Echinococcus granulosus	mothers against decapentaplegic 5	0.0076	0.0131	0.0131
Echinococcus granulosus	Smad4	0.0076	0.0131	0.0131
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.0093	0.0093
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.025	1
Schistosoma mansoni	cellular tumor antigen P53	0.0405	0.0901	0.0901
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0049	0.0068	0.2712
Onchocerca volvulus		0.0033	0.0031	0.011
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0047	0.0047
Echinococcus multilocularis	expressed protein	0.0061	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0124	0.0484
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0163	0.0336	0.0336
Schistosoma mansoni	hypothetical protein	0.0163	0.0336	0.0336
Echinococcus multilocularis	beta LACTamase domain containing family member	0.004	0.0047	0.0047
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0031	0.0132
Onchocerca volvulus		0.1018	0.2339	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0009	0.004
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0314	0.0688	0.294
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0049	0.0068	0.0068
Plasmodium falciparum	phd finger protein, putative	0.0032	0.0029	0.9049
Schistosoma mansoni	hypothetical protein	0.0163	0.0336	0.0336
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0031	0.0132
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0895	0.2049	0.7989
Echinococcus granulosus	histone lysine methyltransferase setb	0.0128	0.0254	0.0254
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0093	0.299
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0047	0.0202
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0033	0.0031	0.0031
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0128	0.0254	0.0254
Schistosoma mansoni	sodium/chloride dependent transporter	0.0073	0.0124	0.0124
Leishmania major	cathepsin L-like protease	0.0033	0.0031	0.1239
Plasmodium vivax	vivapain-2	0.0033	0.0031	0.0842
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0163	0.0336	0.131
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0044	0.0057	0.2291
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0049	0.0068	0.0068
Onchocerca volvulus		0.0167	0.0343	0.145
Schistosoma mansoni	lamin	0.0085	0.0152	0.0152
Loa Loa (eye worm)	hypothetical protein	0.004	0.0047	0.0184
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0031	0.0132
Schistosoma mansoni	ferritin light chain	0.0061	0.0096	0.0096
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0031	0.0132
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0031	0.0121
Brugia malayi	beta-lactamase family protein	0.004	0.0047	0.0184
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0314	0.0688	0.294
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.001	0.0419
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0076	0.0131	0.0131
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0031	0.0132
Loa Loa (eye worm)	hypothetical protein	0.004	0.0047	0.0184
Echinococcus granulosus	smad	0.0076	0.0131	0.0131
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0163	0.0336	0.0336
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0049	0.0068	0.2712
Brugia malayi	MH1 domain containing protein	0.0042	0.0052	0.0201
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0031	0.0131
Plasmodium vivax	vivapain-2	0.0033	0.0031	0.0842
Loa Loa (eye worm)	ctsf protein	0.0033	0.0031	0.0121
Brugia malayi	MH2 domain containing protein	0.0076	0.0131	0.0511
Onchocerca volvulus		0.0085	0.0152	0.0628
Echinococcus multilocularis	ubiquitin specific protease 41	0.0049	0.0068	0.0068
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0031	0.0132
Loa Loa (eye worm)	cysteine protease	0.0033	0.0031	0.0121
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0036	0.0154
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.025	1
Loa Loa (eye worm)	MH1 domain-containing protein	0.0034	0.0033	0.0127
Echinococcus granulosus	biogenic amine 5HT receptor	0.015	0.0304	0.0304
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0033	0.0031	0.0825
Brugia malayi	jmjC domain containing protein	0.0039	0.0045	0.0175
Brugia malayi	MH1 domain containing protein	0.0042	0.0052	0.0201
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.025	1
Brugia malayi	mothers against decapentaplegic homolog 3	0.0034	0.0033	0.0127
Echinococcus multilocularis	lamin dm0	0.0085	0.0152	0.0152
Echinococcus granulosus	tar DNA binding protein	0.0198	0.0417	0.0417
Echinococcus granulosus	cathepsin l1	0.0033	0.0031	0.0031
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0031	0.0132
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0057	0.0245
Schistosoma mansoni	lamin	0.0085	0.0152	0.0152
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0044	0.0057	0.2291
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0343	0.1339
Leishmania major	cathepsin L-like protease	0.0033	0.0031	0.1239
Echinococcus multilocularis	musashi	0.0085	0.0152	0.0152
Echinococcus multilocularis	cathepsin L cysteine protease	0.0033	0.0031	0.0031
Giardia lamblia	PHD finger protein 15	0.0032	0.0029	0.0422
Onchocerca volvulus	Mothers against decapentaplegic homolog	0.0034	0.0033	0.0118
Brugia malayi	beta-lactamase family protein	0.004	0.0047	0.0184
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0198	0.0417	0.1625
Schistosoma mansoni	apoferritin-2	0.0061	0.0096	0.0096
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0073	0.0124	0.0484
Echinococcus multilocularis	cysteine protease	0.0033	0.0031	0.0031
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0044	0.0057	0.0057
Toxoplasma gondii	aldehyde dehydrogenase	0.006	0.0093	0.3404
Toxoplasma gondii	cathepsin CPL	0.0033	0.0031	0.0842
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0083	0.0324
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0257	0.0555	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0031	0.0132
Trypanosoma brucei	hypothetical protein, conserved	0.004	0.0047	0.1894
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0047	0.0202
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0047	0.1894
Echinococcus granulosus	expressed protein	0.0061	0.0096	0.0096
Echinococcus multilocularis	mothers against decapentaplegic 2	0.0034	0.0033	0.0033
Loa Loa (eye worm)	norepinephrine transporter	0.0073	0.0124	0.0484
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0031	0.0131
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0163	0.0336	0.131
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0057	0.0245
Trypanosoma cruzi	cruzipain precursor, putative	0.0127	0.025	1
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0047	0.0202
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0031	0.0121
Toxoplasma gondii	PHD-finger domain-containing protein	0.0032	0.0029	0.0762
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0009	0.004
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0314	0.0688	0.294
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0049	0.0068	0.029
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0031	0.0132
Onchocerca volvulus		0.0033	0.0031	0.011
Brugia malayi	jmjC domain containing protein	0.0106	0.0202	0.0786
Loa Loa (eye worm)	nuclear factor I	0.0042	0.0052	0.0201
Echinococcus multilocularis	GPCR, family 2	0.0163	0.0336	0.0336
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0031	0.0121
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0015	0.0065
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0106	0.0202	0.0202
Echinococcus multilocularis	serotonin receptor	0.015	0.0304	0.0304
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0047	0.1894
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0035	0.0036	0.1441
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0124	0.0484
Loa Loa (eye worm)	TAR-binding protein	0.0198	0.0417	0.1625
Echinococcus multilocularis	cathepsin L cysteine protease	0.0033	0.0031	0.0031
Mycobacterium tuberculosis	Bacterioferritin BfrB	0.0061	0.0096	0.1722
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0047	0.0202
Onchocerca volvulus		0.0405	0.0901	0.384
Mycobacterium ulcerans	lipase LipD	0.004	0.0047	0.1517
Mycobacterium ulcerans	beta-lactamase	0.004	0.0047	0.1517
Schistosoma mansoni	hypothetical protein	0.0163	0.0336	0.0336
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0076	0.0131	0.0131
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0076	0.0131	0.0131
Entamoeba histolytica	cysteine proteinase, putative	0.0022	0.0005	0.0076
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0049	0.0068	0.0068
Schistosoma mansoni	tar DNA-binding protein	0.0198	0.0417	0.0417
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0073	0.0124	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0516	0.1163	0.4534
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0049	0.0068	0.029
Loa Loa (eye worm)	hypothetical protein	0.0353	0.078	0.3042
Loa Loa (eye worm)	transcription factor SMAD2	0.1115	0.2565	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0009	0.0039
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0044	0.0057	0.0832
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0033	0.0031	0.0121
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0031	0.0132
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0036	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0045	0.0177
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.001	0.0419
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0021	0.0088
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0093	0.299
Schistosoma mansoni	smad	0.0034	0.0033	0.0033
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.0093	0.3735
Onchocerca volvulus		0.004	0.0047	0.018
Schistosoma mansoni	Smad4	0.0076	0.0131	0.0131
Echinococcus multilocularis	cysteine protease	0.0033	0.0031	0.0031
Loa Loa (eye worm)	serotonin transporter b	0.0073	0.0124	0.0484
Echinococcus granulosus	serotonin transporter	0.0073	0.0124	0.0124
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0031	0.0132
Brugia malayi	Pre-SET motif family protein	0.0895	0.2049	0.7989
Leishmania major	cathepsin L-like protease	0.0127	0.025	1
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0021	0.0002	0.0093
Echinococcus granulosus	mothers against decapentaplegic 2	0.0034	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0068	0.0264
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.004	0.0047	0.0184
Brugia malayi	beta-lactamase	0.004	0.0047	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0029	0.0113
Brugia malayi	RNA binding protein	0.0198	0.0417	0.1625
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0516	0.1163	0.4534
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0033	0.0031	0.0031
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.0031	0.045
Loa Loa (eye worm)	hypothetical protein	0.015	0.0304	0.1186
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0044	0.0057	0.2291
Schistosoma mansoni	tar DNA-binding protein	0.0198	0.0417	0.0417
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0128	0.0254	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.025	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0031	0.0132
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0044	0.0057	0.0832
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.004	0.0047	0.0852
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0009	0.004
Schistosoma mansoni	ferritin	0.0061	0.0096	0.0096
Schistosoma mansoni	hypothetical protein	0.0163	0.0336	0.0336
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0163	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0005	0.002
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0039	0.0045	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0254	0.0989
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0015	0.0063
Loa Loa (eye worm)	MH1 domain-containing protein	0.0076	0.0131	0.0511
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.001	0.0419
Mycobacterium tuberculosis	Conserved protein	0.004	0.0047	0.0852
Loa Loa (eye worm)	intermediate filament protein	0.0085	0.0152	0.0592
Schistosoma mansoni	cathepsin F (C01 family)	0.0033	0.0031	0.0031
Trypanosoma cruzi	cysteine peptidase, putative	0.0127	0.025	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.004	0.0047	0.1517
Leishmania major	hypothetical protein, conserved	0.0024	0.001	0.0419
Leishmania major	cysteine peptidase A (CPA)	0.0033	0.0031	0.1239
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0116	0.0224	0.8969
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0045	0.006	0.0232
Brugia malayi	Intermediate filament tail domain containing protein	0.0085	0.0152	0.0592
Giardia lamblia	GTOR	0.0044	0.0057	0.0832
Trypanosoma cruzi	cysteine peptidase, putative	0.0127	0.025	1
Loa Loa (eye worm)	fibroinase	0.0033	0.0031	0.0121
Schistosoma mansoni	smad	0.0076	0.0131	0.0131
Brugia malayi	Papain family cysteine protease containing protein	0.0033	0.0031	0.0121
Schistosoma mansoni	hypothetical protein	0.0353	0.078	0.078
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0041	0.0049	0.0049
Plasmodium vivax	SET domain protein, putative	0.0128	0.0254	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0031	0.0132
Echinococcus granulosus	mothers against decapentaplegic 6	0.0034	0.0033	0.0033
Schistosoma mansoni	smad1 5 8 and	0.0076	0.0131	0.0131
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0049	0.0068	0.0264
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.0093	0.168
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0031	0.0131
Schistosoma mansoni	biogenic amine (5HT) receptor	0.015	0.0304	0.0304
Toxoplasma gondii	PHD-finger domain-containing protein	0.0032	0.0029	0.0762
Brugia malayi	hypothetical protein	0.0167	0.0343	0.1339
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0163	0.0336	0.0336
Echinococcus granulosus	tumor protein p63	0.2765	0.6431	0.6431
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0044	0.0057	0.2291
Echinococcus granulosus	ubiquitin specific protease 41	0.0049	0.0068	0.0068
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.025	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0031	0.0131
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.0031	0.045
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0031	0.045
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0009	0.0039
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0015	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0031	0.0121
Echinococcus multilocularis	serotonin receptor	0.015	0.0304	0.0304
Schistosoma mansoni	tar DNA-binding protein	0.0198	0.0417	0.0417
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0035	0.0036	0.1441
Trypanosoma cruzi	target of rapamycin kinase 3	0.0035	0.0036	0.1441
Brugia malayi	Bromodomain containing protein	0.0032	0.0029	0.0113
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0106	0.0202	0.0202
Echinococcus multilocularis	lysine specific demethylase 5A	0.0039	0.0045	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0152	0.0592
Schistosoma mansoni	cathepsin F (C01 family)	0.0022	0.0005	0.0005
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0314	0.0688	0.294
Brugia malayi	Smad1	0.0076	0.0131	0.0511
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0023	0.0098
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0049	0.0068	0.0985
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0516	0.1163	0.4534
Schistosoma mansoni	hypothetical protein	0.0032	0.0029	0.0029
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0044	0.0057	0.0057
Onchocerca volvulus		0.0033	0.0031	0.011
Mycobacterium ulcerans	hypothetical protein	0.004	0.0047	0.1517
Loa Loa (eye worm)	hypothetical protein	0.004	0.0047	0.0184
Treponema pallidum	sodium- and chloride- dependent transporter	0.0073	0.0124	0.0482
Loa Loa (eye worm)	PHD-finger family protein	0.0032	0.0029	0.0113
Echinococcus multilocularis	mothers against decapentaplegic 6	0.0034	0.0033	0.0033
Brugia malayi	cytoplasmic intermediate filament protein	0.0045	0.006	0.0232
Leishmania major	cathepsin L-like protease	0.0033	0.0031	0.1239
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0031	0.0131
Leishmania major	cathepsin L-like protease	0.0033	0.0031	0.1239
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0314	0.0688	0.294
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0044	0.0057	0.2291
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0031	0.0132

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 460 nM	Displacement of [3H]citalopram from SERT in rat cerebral cortex by liquid scintillation counting	ChEMBL.	19665823
Ki (binding)	= 1.5 uM	Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampus	ChEMBL.	19665823

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL567460

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1069264