Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0061 | 0.0746 | 0.1023 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0069 | 0.0925 | 0.1168 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.0925 | 0.086 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.4993 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.1237 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.0111 | 0.004 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0241 | 0.0257 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0063 | 0.0779 | 0.1073 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0241 | 0.0239 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0111 | 0.006 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.0925 | 0.1295 |
Echinococcus granulosus | tumor protein p63 | 0.036 | 0.7371 | 0.7352 |
Schistosoma mansoni | hypothetical protein | 0.0328 | 0.6661 | 1 |
Echinococcus granulosus | snurportin 1 | 0.0328 | 0.6661 | 0.6636 |
Echinococcus multilocularis | snurportin 1 | 0.0328 | 0.6661 | 0.6636 |
Brugia malayi | jmjC domain containing protein | 0.0063 | 0.0779 | 0.0961 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0055 | 0.0601 | 0.0785 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.0925 | 0.086 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0491 | 0.0636 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0111 | 0.004 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.0316 | 0.0634 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0057 | 0.0655 | 0.08 |
Brugia malayi | hypothetical protein | 0.023 | 0.4483 | 0.5995 |
Plasmodium falciparum | importin beta, putative | 0.0031 | 0.0072 | 0.0373 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0065 | 0.0824 | 1 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0061 | 0.0746 | 0.8656 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0241 | 0.0239 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0038 | 0.0241 | 0.0239 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.007 | 0.0947 | 0.119 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.3067 | 0.6142 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0175 | 0.3264 | 0.6538 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0241 | 0.0239 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0039 | 0.0251 | 0.0619 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0491 | 0.0422 |
Onchocerca volvulus | 0.0164 | 0.3025 | 0.986 | |
Echinococcus granulosus | survival motor neuron protein 1 | 0.023 | 0.4483 | 0.4443 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0491 | 0.0422 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.023 | 0.4483 | 0.4443 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0038 | 0.0241 | 0.081 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0241 | 0.0257 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0083 | 0.1237 | 1 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0055 | 0.0601 | 0.0533 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.4993 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0038 | 0.0241 | 0.0171 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0362 | 0.7429 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.3067 | 0.6142 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0065 | 0.0824 | 0.659 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.0824 | 0.5855 |
Echinococcus granulosus | geminin | 0.0165 | 0.304 | 0.2989 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0083 | 0.1237 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0491 | 0.0422 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.1237 | 0.1591 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.4993 | 1 |
Brugia malayi | beta-lactamase | 0.0038 | 0.0241 | 0.023 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.4993 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.4993 | 1 |
Onchocerca volvulus | 0.0053 | 0.0559 | 0.1645 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0491 | 0.0422 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3025 | 0.4019 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.1237 | 1 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0083 | 0.1237 | 0.1173 |
Loa Loa (eye worm) | beta-lactamase | 0.0038 | 0.0241 | 0.0239 |
Echinococcus multilocularis | tumor protein p63 | 0.036 | 0.7371 | 0.7352 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0491 | 0.0578 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.1237 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.2284 | 0.3013 |
Trichomonas vaginalis | esterase, putative | 0.0038 | 0.0241 | 0.0483 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0103 | 0.1668 | 0.2176 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.0925 | 0.1853 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.043 | 0.0543 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0241 | 0.0483 |
Toxoplasma gondii | ABC1 family protein | 0.0038 | 0.0241 | 0.1772 |
Brugia malayi | hypothetical protein | 0.013 | 0.2284 | 0.3007 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0063 | 0.0779 | 0.0712 |
Onchocerca volvulus | 0.0038 | 0.0241 | 0.0586 | |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0241 | 0.0239 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0253 | 0.4993 | 0.6692 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0083 | 0.1237 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0038 | 0.0241 | 0.1772 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0111 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.2284 | 0.3013 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.3067 | 0.6142 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.3067 | 0.6142 |
Brugia malayi | Heterochromatin protein 1 | 0.0069 | 0.0925 | 0.116 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.1237 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0559 | 0.067 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0111 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.023 | 0.4483 | 0.5999 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.0925 | 0.086 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0103 | 0.1668 | 0.2169 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0111 | 0.004 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.0824 | 0.5855 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0947 | 0.1198 |
Schistosoma mansoni | jumonji domain containing protein | 0.0063 | 0.0779 | 0.1073 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0065 | 0.0824 | 0.0758 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0103 | 0.1668 | 0.2169 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.1237 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0.0241 | 0.1772 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0251 | 0.0503 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0038 | 0.0241 | 0.023 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0061 | 0.0746 | 0.0916 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.3067 | 0.6142 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0038 | 0.0241 | 0.0171 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0055 | 0.0601 | 0.0785 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0065 | 0.0824 | 0.1272 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.043 | 0.0486 |
Onchocerca volvulus | 0.0038 | 0.0241 | 0.0586 | |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0328 | 0.6661 | 0.8956 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0053 | 0.0559 | 0.0739 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0241 | 0.0483 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.1237 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0072 | 0.0009 |
Brugia malayi | hypothetical protein | 0.0164 | 0.3025 | 0.4013 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0111 | 0.004 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0241 | 0.023 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0031 | 0.0072 | 0.0373 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.0111 | 0.0063 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0063 | 0.0779 | 0.0969 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0061 | 0.0746 | 0.5068 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0055 | 0.0601 | 0.0533 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0063 | 0.0779 | 0.0712 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.0824 | 0.1142 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0055 | 0.0601 | 0.4744 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0063 | 0.0779 | 0.1073 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0061 | 0.0746 | 0.0679 |
Mycobacterium leprae | conserved hypothetical protein | 0.0038 | 0.0241 | 0.1772 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0241 | 0.0483 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0065 | 0.0824 | 0.0758 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.043 | 0.0543 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.0925 | 0.086 |
Brugia malayi | MH2 domain containing protein | 0.0362 | 0.7429 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.0316 | 0.0634 |
Trypanosoma brucei | RNA helicase, putative | 0.0125 | 0.2163 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.304 | 0.4504 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0241 | 0.0483 |
Brugia malayi | Probable ClpP-like protease | 0.0083 | 0.1237 | 0.1583 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0245 | 0.4823 | 1 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0947 | 0.1328 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0241 | 0.023 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0253 | 0.4993 | 0.6689 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0111 | 0.0063 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0063 | 0.0779 | 0.0712 |
Onchocerca volvulus | Huntingtin homolog | 0.013 | 0.2284 | 0.7393 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0061 | 0.0746 | 0.5068 |
Onchocerca volvulus | Huntingtin homolog | 0.013 | 0.2284 | 0.7393 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.0925 | 0.1295 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0111 | 0.006 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.3067 | 0.6142 |
Brugia malayi | chromobox protein homolog 3 | 0.0039 | 0.0251 | 0.0243 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.0925 | 0.1853 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.0111 | 0.004 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.0111 | 0.0054 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0111 | 0.006 |
Brugia malayi | jmjC domain containing protein | 0.0063 | 0.0779 | 0.0961 |
Plasmodium vivax | importin-beta 2, putative | 0.0031 | 0.0072 | 0.0373 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0362 | 0.7429 | 1 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0083 | 0.1237 | 0.1768 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 0.2163 | 0.3174 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0061 | 0.0746 | 0.1101 |
Onchocerca volvulus | 0.0047 | 0.043 | 0.1214 | |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.1237 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.0824 | 0.5855 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.0111 | 0.0054 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0061 | 0.0746 | 0.0679 |
Onchocerca volvulus | 0.0038 | 0.0241 | 0.0586 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0491 | 0.0636 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0241 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0175 | 0.3264 | 0.6538 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0241 | 0.0239 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.1668 | 0.2176 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.3067 | 0.6142 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0241 | 0.0483 |
Echinococcus multilocularis | geminin | 0.0165 | 0.304 | 0.2989 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0241 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.4993 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0241 | 0.0239 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0491 | 0.0569 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0251 | 0.0252 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0042 | 0.0316 | 0.0837 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.0824 | 0.1142 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0251 | 0.0503 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0083 | 0.1237 | 0.1173 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0083 | 0.1237 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.304 | 0.4504 |
Brugia malayi | RNA, U transporter 1 | 0.0087 | 0.1327 | 0.1706 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0166 | 0.3067 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0063 | 0.0779 | 0.0712 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0491 | 0.0636 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 99 uM | Inhibition of HIV1 integrase strand transfer activity expressed in Escherichia coli by PAGE | ChEMBL. | 19527935 |
IC50 (binding) | > 333 uM | Inhibition of HIV1 integrase 3'-processing activity expressed in Escherichia coli by PAGE | ChEMBL. | 19527935 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.