Detailed information for compound 1069666

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 545.871 | Formula: C24H19Cl3N6OS
  • H donors: 0 H acceptors: 5 LogP: 7.18 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: Clc1ccc(cc1)c1c(c2nnc(s2)C)c(nn1c1ccc(cc1Cl)Cl)c1nnc(o1)C(C)(C)C
  • InChi: 1S/C24H19Cl3N6OS/c1-12-28-30-22(35-12)18-19(21-29-31-23(34-21)24(2,3)4)32-33(17-10-9-15(26)11-16(17)27)20(18)13-5-7-14(25)8-6-13/h5-11H,1-4H3
  • InChiKey: IFYVVGNXWDXQOK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Cannabinoid CB1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei glucosidase, putative 0.004 0.0127 0.2652
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0062 0.1253
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0262 0.122 0.1209
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0025 0.0455
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0004 0.0006
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0127 0.0956
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0062 0.1253
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.1927 0.9388 0.9388
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0127 0.2652
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0133 0.2047
Echinococcus multilocularis chromobox protein 1 0.008 0.0327 0.0821
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0089 0.0201
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0127 0.2652
Plasmodium falciparum thioredoxin reductase 0.0055 0.02 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0062 0.0236 0.0584
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0089 0.1296
Schistosoma mansoni transcription factor LCR-F1 0.0081 0.033 0.0829
Loa Loa (eye worm) RecQ helicase 0.0027 0.0066 0.037
Mycobacterium ulcerans beta-lactamase 0.0041 0.0133 0.2047
Onchocerca volvulus Alhambra homolog 0.0032 0.0089 0.1006
Leishmania major GTP-binding protein, putative 0.0025 0.0052 0.0806
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0127 0.2652
Brugia malayi beta-lactamase 0.0041 0.0133 0.1008
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0214 0.0984 0.2537
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0133 0.0122
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0004 0.0016
Schistosoma mansoni hypothetical protein 0.0032 0.0089 0.0201
Loa Loa (eye worm) hypothetical protein 0.0062 0.0236 0.1384
Onchocerca volvulus Glucosylceramidase homolog 0.0186 0.0845 1
Trichomonas vaginalis chromobox protein, putative 0.008 0.0327 0.2449
Entamoeba histolytica hypothetical protein 0.0081 0.033 0.703
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0016 0.0012 0.0182
Chlamydia trachomatis recombinase RecA 0.0125 0.0544 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0089 0.0644
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0025 0.035
Mycobacterium ulcerans aldehyde dehydrogenase 0.0137 0.0605 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.02 0.049
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.017 0.0413
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0075 0.1533
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0127 0.0932
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0081 0.033 0.0829
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0845 0.6374
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0049 0.017 0.1971
Schistosoma mansoni hypothetical protein 0.0081 0.033 0.0829
Brugia malayi chromobox protein homolog 3 0.0045 0.0153 0.1158
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0122 0.0287
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0016 0.0012 0.0182
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.0894 0.6747
Loa Loa (eye worm) hypothetical protein 0.0045 0.0153 0.089
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0133 0.0122
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0038 0.012 0.2513
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0064 0.046
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0062 0.0343
Echinococcus multilocularis microtubule associated protein 2 0.0797 0.3844 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0062 0.0236 0.1782
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.017 0.1264
Toxoplasma gondii aldehyde dehydrogenase 0.0137 0.0605 1
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.015 0.0361
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0025 0.0455
Trichomonas vaginalis chromobox protein, putative 0.0049 0.017 0.1261
Trypanosoma brucei polo-like protein kinase 0.0109 0.0467 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.0004 0.0006
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0151 0.2844
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0004 0.0006
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0151 0.317
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0089 0.0201
Echinococcus multilocularis polycomb protein SCMH1 0.0054 0.0199 0.0488
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0133 0.0772
Schistosoma mansoni myelin transcription factor 1 myt1 0.0062 0.0236 0.0584
Echinococcus granulosus chromobox protein 1 0.008 0.0327 0.0821
Trichomonas vaginalis ran, putative 0.0025 0.0052 0.0367
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0845 0.6374
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0075 0.2855
Loa Loa (eye worm) hypothetical protein 0.0035 0.0105 0.0604
Schistosoma mansoni aldehyde dehydrogenase 0.0137 0.0605 0.1547
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0467 0.3514
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.0467 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0062 0.0236 0.0584
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0095 0.0217
Brugia malayi Importin beta-1 subunit 0.0033 0.0095 0.072
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.005 0.1439
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0052 0.0105
Mycobacterium ulcerans recombinase A 0.0125 0.0544 0.8964
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0133 0.0317
Brugia malayi hypothetical protein 0.0081 0.033 0.2491
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0127 0.0932
Echinococcus granulosus lysosomal alpha glucosidase 0.0179 0.081 0.2081
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0845 0.6374
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0256 0.1505
Loa Loa (eye worm) glutathione reductase 0.0055 0.02 0.1169
Brugia malayi mbt repeat family protein 0.0054 0.0199 0.1503
Loa Loa (eye worm) cytochrome P450 family protein 0.0038 0.012 0.0693
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0089 0.0505
Leishmania major cytochrome p450-like protein 0.0026 0.0062 0.0966
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0467 0.3514
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.0467 1
Entamoeba histolytica hypothetical protein 0.0081 0.033 0.703
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.0609 0.3613
Mycobacterium ulcerans hypothetical protein 0.0041 0.0133 0.2047
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0125 0.0544 1
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0133 0.0984
Echinococcus granulosus snurportin 1 0.0356 0.1677 0.4345
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0133 0.0122
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.02 1
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0133 0.2799
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0064 0.131
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0004 0.0006
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0064 0.046
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.1323 1
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0845 0.6374
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0284 0.1323 1
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0197 0.1465
Mycobacterium tuberculosis Conserved protein 0.0041 0.0133 0.0122
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0125 0.0543 0.1514
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0004 0.0006
Schistosoma mansoni hypothetical protein 0.0197 0.0897 0.2311
Echinococcus granulosus polycomb protein SCMH1 0.0054 0.0199 0.0488
Loa Loa (eye worm) hypothetical protein 0.0041 0.0133 0.0772
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0133 0.0346
Schistosoma mansoni alpha glucosidase 0.004 0.0127 0.0299
Schistosoma mansoni ran 0.0025 0.0052 0.0105
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0105 0.0446 0.1133
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0109 0.0467 0.1188
Loa Loa (eye worm) hypothetical protein 0.0054 0.0199 0.1163
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0845 0.6374
Onchocerca volvulus 0.0041 0.0133 0.1536
Brugia malayi PHD-finger family protein 0.0032 0.0089 0.0671
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0109 0.0467 0.1188
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0025 0.0213
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0127 0.0299
Schistosoma mansoni kinase 0.0055 0.0204 0.0501
Echinococcus multilocularis lysosomal alpha glucosidase 0.0179 0.081 0.2081
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.017 0.2672
Brugia malayi Cytochrome P450 family protein 0.0026 0.0062 0.0466
Schistosoma mansoni aldehyde dehydrogenase 0.0137 0.0605 0.1547
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0122 0.0703
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0199 0.0488
Brugia malayi Cytochrome P450 family protein 0.0016 0.0012 0.0091
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0095 0.1403
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0125 0.0544 0.1515
Loa Loa (eye worm) hypothetical protein 0.0055 0.0201 0.1176
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0022 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0153 0.1134
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0122 0.0287
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0062 0.0343
Schistosoma mansoni alpha-glucosidase 0.0154 0.0687 0.1762
Plasmodium falciparum phd finger protein, putative 0.0032 0.0089 0.3664
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0004 0.0016
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0016 0.0012 0.014
Schistosoma mansoni chromobox protein 0.008 0.0327 0.0821
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0845 0.6374
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0062 0.0343
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0025 0.0113
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0127 0.0731
Brugia malayi Bloom's syndrome protein homolog 0.0027 0.0066 0.05
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0025 0.0033
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0467 0.3514
Loa Loa (eye worm) hypothetical protein 0.0041 0.0133 0.0772
Schistosoma mansoni microtubule-associated protein tau 0.0797 0.3844 1
Onchocerca volvulus 0.0175 0.0793 0.9383
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0025 0.0455
Mycobacterium ulcerans aldehyde dehydrogenase 0.0137 0.0605 1
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0467 0.3514
Brugia malayi Cytochrome P450 family protein 0.0038 0.012 0.0908
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0122 0.0287
Brugia malayi serine/threonine-protein kinase plk-2 0.0109 0.0467 0.3531
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0125 0.0543 0.0532
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0356 0.1677 1
Echinococcus granulosus jumonji domain containing protein 0.0045 0.015 0.0361
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0133 0.0984
Mycobacterium ulcerans aldehyde dehydrogenase 0.0137 0.0605 1
Loa Loa (eye worm) cytochrome P450 0.0016 0.0012 0.0046
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0197 0.1465
Leishmania major glycosyl hydrolase-like protein 0.0015 0.0004 0.0012
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.0052 0.166
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0127 0.2045
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0467 0.3514
Loa Loa (eye worm) hypothetical protein 0.0041 0.0133 0.0772
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0052 0.1046
Brugia malayi jmjC domain containing protein 0.0039 0.0122 0.0921
Loa Loa (eye worm) acetyltransferase 0.0165 0.0743 0.4419
Echinococcus multilocularis chromobox protein 1 0.008 0.0327 0.0821
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0025 0.0455
Trichomonas vaginalis esterase, putative 0.0041 0.0133 0.0984
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0138 0.0611 0.06
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.0894 0.6747
Schistosoma mansoni importin beta-1 0.0033 0.0095 0.0217
Brugia malayi hypothetical protein 0.0019 0.0024 0.0181
Echinococcus granulosus SAM and MBT domain containing protein 0.0054 0.0199 0.0488
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0052 0.0394
Onchocerca volvulus Serine\/threonine kinase homolog 0.0109 0.0467 0.5508
Plasmodium falciparum importin beta, putative 0.0033 0.0095 0.4029
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0004 0.0006
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.017 0.8341
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0133 0.2799
Plasmodium vivax glutathione reductase, putative 0.0055 0.02 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0284 0.1323 0.7886
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0153 0.1134
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0467 0.3514
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0025 0.035
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0127 0.0932
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0025 0.0213
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.02 0.4232
Echinococcus multilocularis SAM and MBT domain containing protein 0.0054 0.0199 0.0488
Loa Loa (eye worm) hypothetical protein 0.0032 0.0089 0.0505
Schistosoma mansoni alpha-glucosidase 0.0154 0.0687 0.1762
Toxoplasma gondii thioredoxin reductase 0.0055 0.02 0.3167
Brugia malayi beta-lactamase family protein 0.0041 0.0133 0.1008
Schistosoma mansoni ran 0.0025 0.0052 0.0105
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0016 0.0012 0.0182
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0214 0.0984 0.2537
Echinococcus multilocularis snurportin 1 0.0356 0.1677 0.4345
Mycobacterium tuberculosis Probable oxidoreductase 0.0138 0.0611 0.06
Onchocerca volvulus 0.0035 0.0105 0.1202
Echinococcus multilocularis lysosomal alpha glucosidase 0.0179 0.081 0.2081
Loa Loa (eye worm) hypothetical protein 0.0041 0.0133 0.0772
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0025 0.0455
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0025 0.0455
Leishmania major importin beta-1 subunit, putative 0.0027 0.0064 0.101
Loa Loa (eye worm) heterochromatin protein 1 0.008 0.0327 0.1928
Leishmania major cytochrome p450-like protein 0.0016 0.0012 0.014
Entamoeba histolytica hypothetical protein 0.0081 0.033 0.703
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0052 0.0105
Schistosoma mansoni chromobox protein 0.008 0.0327 0.0821
Echinococcus granulosus histone acetyltransferase KAT2B 0.0161 0.0721 0.1849
Mycobacterium tuberculosis Conserved protein 0.0041 0.0133 0.0122
Trichomonas vaginalis DNA helicase recq1, putative 0.0027 0.0066 0.0474
Echinococcus multilocularis peregrin 0.0036 0.0109 0.0252
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0054 0.0199 0.0488
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0179 0.081 0.4815
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0153 0.1771
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0133 0.0122
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0064 0.046
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0137 0.0605 0.0594
Leishmania major hypothetical protein, conserved 0.0041 0.0133 0.2158
Trypanosoma brucei trypanothione reductase 0.0055 0.02 0.4232
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0025 0.0033
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0127 0.0932
Loa Loa (eye worm) MBCTL1 0.0062 0.0236 0.1384
Echinococcus granulosus chromobox protein 1 0.008 0.0327 0.0821
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.02 0.1169
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0133 0.0122
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0025 0.035
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0133 0.0122
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0025 0.016
Echinococcus granulosus bloom syndrome protein 0.0027 0.0066 0.0141
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0052 0.1565
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0025 0.0455
Leishmania major hypothetical protein, conserved 0.0029 0.0075 0.1182
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0089 0.0644
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0105 0.0446 0.1133
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0127 0.2652
Trichomonas vaginalis DNA helicase recq, putative 0.0027 0.0066 0.0474
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0125 0.0543 0.0532
Giardia lamblia Kinase, PLK 0.0109 0.0467 1
Entamoeba histolytica Ran family GTPase 0.0025 0.0052 0.1046
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0125 0.0543 0.0532
Loa Loa (eye worm) mbt repeat family protein 0.0054 0.0199 0.1163
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0127 0.0932
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0075 0.1533
Brugia malayi RNA, U transporter 1 0.0095 0.0397 0.2997
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0025 0.0455
Brugia malayi MH2 domain containing protein 0.0138 0.0609 0.4599
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.1323 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0095 0.0544
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.017 0.1264
Echinococcus granulosus importin subunit beta 1 0.0033 0.0095 0.0217
Loa Loa (eye worm) hypothetical protein 0.0175 0.0793 0.4715
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0004 0.0006
Echinococcus granulosus histone acetyltransferase MYST2 0.0062 0.0236 0.0584
Brugia malayi Thioredoxin reductase 0.0055 0.02 0.151
Trypanosoma cruzi DNA repair protein, putative 0.0038 0.012 0.2513
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0137 0.0605 1
Leishmania major cytochrome p450-like protein 0.0016 0.0012 0.014
Loa Loa (eye worm) beta-lactamase 0.0041 0.0133 0.0772
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0075 0.2935
Schistosoma mansoni blooms syndrome DNA helicase 0.0022 0.0038 0.0068
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0133 0.0984
Mycobacterium leprae Conserved hypothetical protein 0.0731 0.352 1
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.1323 1
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.1323 1
Mycobacterium leprae Probable lipase LipE 0.0041 0.0133 0.0346
Brugia malayi hypothetical protein 0.0175 0.0793 0.5992
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0054 0.0199 0.2315
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0845 0.6374
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0133 0.2799
Mycobacterium tuberculosis Conserved protein 0.0041 0.0133 0.0122
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0025 0.0013
Trypanosoma cruzi DNA repair protein, putative 0.0038 0.012 0.2513
Echinococcus granulosus peregrin 0.0036 0.0109 0.0252
Trichomonas vaginalis chromobox protein, putative 0.0049 0.017 0.1261
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0052 0.1046
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0127 0.1932
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0133 0.0317
Loa Loa (eye worm) hypothetical protein 0.0138 0.0608 0.3612
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0127 0.0932
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0004 0.0033
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0467 0.1188
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0025 0.0455
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0075 0.1533
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0025 0.035
Leishmania major trypanothione reductase 0.0055 0.02 0.3263
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0025 0.0455
Schistosoma mansoni jumonji domain containing protein 0.0083 0.034 0.0857
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0127 0.0932
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0062 0.1253
Schistosoma mansoni hypothetical protein 0.0197 0.0897 0.2311
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0133 0.0984
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0138 0.0611 0.06
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.017 0.2672
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.0609 0.3613
Mycobacterium tuberculosis Probable reductase 0.0125 0.0543 0.0532
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0089 0.0201
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0062 0.0236 0.0584
Entamoeba histolytica serine/threonine protein kinase, putative 0.0109 0.0467 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0025 0.0455
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0095 0.1977
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0127 0.0932
Entamoeba histolytica hypothetical protein 0.0081 0.033 0.703
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0062 0.0838
Brugia malayi jmjC domain containing protein 0.0105 0.0446 0.3372
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0133 0.0317
Plasmodium falciparum glutathione reductase 0.0055 0.02 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0133 0.0772
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0025 0.0186
Onchocerca volvulus 0.0103 0.0439 0.5178
Trichomonas vaginalis chromobox protein, putative 0.008 0.0327 0.2449
Brugia malayi glutathione reductase 0.0055 0.02 0.151
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0133 0.0317
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0089 0.3736
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0089 0.1296
Echinococcus multilocularis bloom syndrome protein 0.0027 0.0066 0.0141
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0151 0.7187
Entamoeba histolytica hypothetical protein 0.0027 0.0064 0.131
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0133 0.1008
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0199 0.0488
Brugia malayi mbt repeat family protein 0.0054 0.0199 0.1503
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0052 0.1046
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0109 0.0467 0.771
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0052 0.0286
Schistosoma mansoni hypothetical protein 0.0356 0.1677 0.4345
Schistosoma mansoni hypothetical protein 0.0331 0.1555 0.4028
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0165 0.0743 0.1909
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0095 0.1977
Brugia malayi Bromodomain containing protein 0.0036 0.0109 0.0822
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0133 0.0122
Brugia malayi cytochrome P450 0.0016 0.0012 0.0091
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0127 0.0299
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0137 0.0605 0.1547
Brugia malayi acetyltransferase, GNAT family protein 0.0165 0.0743 0.5618
Brugia malayi beta-lactamase family protein 0.0041 0.0133 0.1008
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0025 0.0113
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0025 0.016
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0109 0.0467 0.2768
Mycobacterium tuberculosis Probable dehydrogenase 0.0125 0.0543 0.0532
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0075 0.2855
Brugia malayi hypothetical protein 0.0029 0.0075 0.0564
Treponema pallidum recombinase A 0.0125 0.0544 1
Brugia malayi Cytochrome P450 family protein 0.0026 0.0062 0.0466
Brugia malayi Glycosyl hydrolases family 31 protein 0.0179 0.081 0.6118
Mycobacterium ulcerans lipase LipD 0.0041 0.0133 0.2047
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.1323 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.02 0.0188
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0081 0.033 0.0829
Echinococcus granulosus geminin 0.0197 0.0897 0.2311
Giardia lamblia PHD finger protein 15 0.0032 0.0089 0.145
Brugia malayi Heterochromatin protein 1 0.008 0.0327 0.2469
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0075 0.1057
Toxoplasma gondii ABC1 family protein 0.0041 0.0133 0.2047
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.0004 0.0016
Plasmodium vivax importin-beta 2, putative 0.0033 0.0095 0.4096
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0122 0.0287
Onchocerca volvulus 0.0054 0.0199 0.2315
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0025 0.0052 0.0619
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0133 0.6249
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.0004 0.0016
Echinococcus multilocularis geminin 0.0197 0.0897 0.2311
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0025 0.0033
Onchocerca volvulus 0.0041 0.0133 0.1536
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0025 0.0052 0.0676
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0016 0.0012 0.0182
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0025 0.0213
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0125 0.0543 0.0532
Loa Loa (eye worm) hypothetical protein 0.0029 0.0075 0.0421
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.1323 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0025 0.0455
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0127 0.0932
Loa Loa (eye worm) hypothetical protein 0.0041 0.0133 0.0772
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.02 0.049
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0133 0.2047
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0165 0.0743 0.1909
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0137 0.0605 0.1547
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0025 0.0213
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0467 0.3514
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0133 0.0984
Onchocerca volvulus 0.0041 0.0133 0.1536
Echinococcus granulosus microtubule associated protein 2 0.0797 0.3844 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0138 0.0611 0.1709
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0004 0.0006
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0025 0.0213
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0025 0.0455

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.83 nM Displacement of [3H]CP-55940 from CB1 receptor in Sprague-Dawley rat cerebellar membrane ChEMBL. 19850473

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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