Detailed information for compound 1069693

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 396.486 | Formula: C21H28N6O2
  • H donors: 1 H acceptors: 4 LogP: 3.09 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCN(c1nc(C)nc2c1c(C)nn2c1ccc(cc1C)C(=O)N)CCC
  • InChi: 1S/C21H28N6O2/c1-6-9-26(10-11-29-5)20-18-14(3)25-27(21(18)24-15(4)23-20)17-8-7-16(19(22)28)12-13(17)2/h7-8,12H,6,9-11H2,1-5H3,(H2,22,28)
  • InChiKey: UQYJVIVWKJSVEQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens corticotropin releasing hormone receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum IPR001879,Hormone receptor, extracellular,domain-containing Get druggable targets OG5_130760 All targets in OG5_130760
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative Get druggable targets OG5_130760 All targets in OG5_130760
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130760 All targets in OG5_130760
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c corticotropin releasing hormone receptor 1 444 aa 445 aa 25.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.034 0.0541
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0564 0.1668
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0102 0.0102
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0431 0.0578
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0021 0.0157 0.1852
Schistosoma mansoni zinc finger protein 0.0034 0.034 0.1006
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.085 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0102 0.0099
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0034 0.034 0.0337
Echinococcus granulosus geminin 0.0187 0.2458 0.2455
Brugia malayi MH1 domain containing protein 0.0017 0.0102 0.0099
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0431 0.0578
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0157 0.1061
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0131 0.0128
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0157 0.1061
Brugia malayi nuclear hormone receptor family member odr-7 0.0034 0.034 0.0337
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0075 0.0885
Loa Loa (eye worm) nuclear receptor NHR-67 0.0034 0.034 0.034
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0157 0.1061
Onchocerca volvulus 0.0107 0.1342 0.2149
Echinococcus multilocularis muscleblind protein 0.0152 0.1974 0.1972
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0073 0.0874 0.0871
Schistosoma mansoni dishevelled 0.001 0.0003 0.001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0667 0.1972
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0303 0.4058 0.4056
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0073 0.0874 0.0871
Brugia malayi tailless protein 0.0034 0.034 0.0337
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0073 0.0874 0.0871
Brugia malayi N-terminal motif family protein 0.0204 0.2696 0.2694
Loa Loa (eye worm) steroid hormone receptor 0.0073 0.0874 0.0874
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0564 0.0561
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0431 0.0578
Schistosoma mansoni hypothetical protein 0.0117 0.1492 0.4412
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0556 0.7576 0.7575
Schistosoma mansoni dishevelled 0.001 0.0003 0.001
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.0131 0.009
Brugia malayi MH2 domain containing protein 0.0017 0.0102 0.0099
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0131 0.0128
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0073 0.0874 0.0874
Schistosoma mansoni Mername-AA248 (C02 family) 0.0021 0.0157 0.0465
Schistosoma mansoni nuclear receptor 0.0034 0.034 0.1006
Loa Loa (eye worm) hypothetical protein 0.0254 0.3381 0.3381
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0131 0.3035
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0431 0.4596
Brugia malayi Nuclear hormone receptor-like 1 0.0073 0.0874 0.0871
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0058 0.0667 0.1972
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.085 0.5
Schistosoma mansoni hypothetical protein 0.0117 0.1492 0.4412
Schistosoma mansoni DNA helicase recq5 0.0019 0.0131 0.0387
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0075 0.0072
Schistosoma mansoni tar DNA-binding protein 0.0126 0.161 0.476
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0131 0.154
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0073 0.0874 0.0871
Echinococcus granulosus nuclear receptor nhr 48 0.0034 0.034 0.0337
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.0003 0.0003
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0397 0.1175
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0073 0.0874 0.0871
Loa Loa (eye worm) calpain family protein 1 0.005 0.0557 0.0557
Loa Loa (eye worm) hypothetical protein 0.0073 0.0874 0.0874
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0157 0.1852
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0073 0.0874 0.1397
Schistosoma mansoni steroid hormone receptor ad4bp 0.0073 0.0874 0.2584
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0131 0.0131
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0564 0.0561
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0073 0.0874 0.0871
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0071 0.085 0.085
Echinococcus multilocularis tar DNA binding protein 0.0126 0.161 0.1607
Schistosoma mansoni tar DNA-binding protein 0.0126 0.161 0.476
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0073 0.0874 0.0874
Brugia malayi hypothetical protein 0.0034 0.034 0.0337
Brugia malayi ecdysteroid receptor 0.0073 0.0874 0.0871
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0003 0.001
Brugia malayi TAR-binding protein 0.0126 0.161 0.1607
Loa Loa (eye worm) hypothetical protein 0.0318 0.427 0.427
Brugia malayi nuclear receptor NHR-88 0.0034 0.034 0.0337
Loa Loa (eye worm) nuclear hormone receptor 0.0034 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.0015 0.0075 0.0075
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0131 0.0128
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0431 0.0578
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0397 0.0394
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0131 0.154
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0131 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0431 0.0578
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0149 0.1931 0.1929
Schistosoma mansoni hypothetical protein 0.0117 0.1492 0.4412
Echinococcus multilocularis calpain A 0.0075 0.09 0.0897
Schistosoma mansoni retinoic acid receptor RXR 0.0073 0.0874 0.2584
Mycobacterium leprae Probable lipase LipE 0.0071 0.085 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.034 0.034
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0073 0.0874 0.0871
Brugia malayi ecdysone receptor 0.0034 0.034 0.0337
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0003 0.001
Brugia malayi beta-lactamase family protein 0.0071 0.085 0.0847
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0034 0.034 0.1006
Trypanosoma cruzi kinesin, putative 0.0021 0.0157 0.1852
Loa Loa (eye worm) hypothetical protein 0.0058 0.0667 0.0667
Brugia malayi calpain 5 0.0021 0.0157 0.0154
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0071 0.085 0.2514
Onchocerca volvulus 0.0071 0.085 0.1358
Echinococcus granulosus calpain 5 0.0021 0.0157 0.0154
Brugia malayi Calcitonin receptor-like protein seb-1 0.0371 0.5009 0.5008
Loa Loa (eye worm) hypothetical protein 0.0073 0.0874 0.0874
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0073 0.0874 0.0871
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0073 0.0874 0.0871
Loa Loa (eye worm) hypothetical protein 0.0117 0.1492 0.1492
Loa Loa (eye worm) hypothetical protein 0.0034 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.005 0.0557 0.0557
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0102 0.0099
Plasmodium vivax calpain, putative 0.0021 0.0157 0.1852
Loa Loa (eye worm) hypothetical protein 0.0034 0.034 0.034
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0637 0.0634
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.085 1
Schistosoma mansoni survival motor neuron protein 0.0149 0.1931 0.5712
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0667 0.1972
Brugia malayi hypothetical protein 0.0318 0.427 0.4268
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0454 0.6162 1
Loa Loa (eye worm) transcription factor SMAD2 0.0252 0.3356 0.3356
Echinococcus multilocularis GPCR, family 2 0.0117 0.1492 0.1489
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0034 0.034 0.0337
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0397 0.0394
Onchocerca volvulus 0.0071 0.085 0.1358
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0131 0.0128
Loa Loa (eye worm) hypothetical protein 0.001 0.00000000011004 0.00000000011004
Echinococcus granulosus tar DNA binding protein 0.0126 0.161 0.1607
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0073 0.0874 0.2584
Brugia malayi calpain family protein 1 0.0071 0.085 0.0847
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0034 0.034 0.034
Schistosoma mansoni hypothetical protein 0.0254 0.3381 1
Brugia malayi nuclear hormone receptor 0.0034 0.034 0.0337
Schistosoma mansoni hypothetical protein 0.0149 0.1931 0.5712
Echinococcus granulosus Smad4 0.0017 0.0102 0.0099
Loa Loa (eye worm) TAR-binding protein 0.0126 0.161 0.161
Echinococcus multilocularis calpain family protein 1, d 0.005 0.0557 0.0553
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0038 0.0397 0.0397
Trypanosoma brucei antigen, putative 0.0021 0.0157 0.1061
Loa Loa (eye worm) Smad1 0.0017 0.0102 0.0102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0073 0.0874 0.0874
Schistosoma mansoni nuclear receptor 0.0034 0.034 0.1006
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.085 0.1257
Entamoeba histolytica calpain large subunit domain III containing protein 0.0021 0.0157 0.365
Loa Loa (eye worm) calpain 0.0021 0.0157 0.0157
Echinococcus granulosus calpain 7 C02 family 0.0021 0.0157 0.0154
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0431 0.0428
Loa Loa (eye worm) hypothetical protein 0.0073 0.0874 0.0874
Onchocerca volvulus 0.0058 0.0667 0.1065
Schistosoma mansoni hypothetical protein 0.0187 0.2458 0.7268
Brugia malayi Glycosyl hydrolases family 31 protein 0.0184 0.242 0.2418
Loa Loa (eye worm) hypothetical protein 0.0071 0.085 0.085
Brugia malayi calpain 7 0.0021 0.0157 0.0154
Plasmodium vivax hypothetical protein, conserved 0.0071 0.085 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.034 0.0337
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0034 0.034 0.0337
Loa Loa (eye worm) hypothetical protein 0.0071 0.085 0.085
Brugia malayi hypothetical protein 0.0038 0.0397 0.0394
Echinococcus granulosus calpain 0.0021 0.0157 0.0154
Echinococcus granulosus calpain A 0.0021 0.0157 0.0154
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.034 0.0337
Echinococcus granulosus muscleblind protein 0.0152 0.1974 0.1972
Brugia malayi calpain family protein 1 0.0071 0.085 0.0847
Leishmania major hypothetical protein, conserved 0.0071 0.085 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0157 0.1852
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0431 0.0578
Echinococcus multilocularis muscleblind protein 1 0.0152 0.1974 0.1972
Entamoeba histolytica protein kinase, putative 0.0021 0.0157 0.365
Loa Loa (eye worm) RecQ helicase 0.0019 0.0131 0.0131
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0431 0.0578
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.034 0.0337
Brugia malayi nuclear receptor NHR-88 0.0073 0.0874 0.0871
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0102 0.0099
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0073 0.0874 0.0871
Echinococcus multilocularis calpain 5 0.0021 0.0157 0.0154
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0073 0.0874 0.0874
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0431 0.0578
Brugia malayi RNA binding protein 0.0126 0.161 0.1607
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.0157 0.0465
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0157 0.1061
Schistosoma mansoni nuclear receptor nhr-48 0.0034 0.034 0.1006
Loa Loa (eye worm) DR-78 0.0034 0.034 0.034
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0431 0.5074
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0073 0.0874 0.2584
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0073 0.0874 0.0874
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.034 0.0337
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0075 0.09 0.2663
Trypanosoma cruzi kinesin, putative 0.0021 0.0157 0.1852
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0117 0.1492 0.1489
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0564 0.0561
Onchocerca volvulus Bile acid receptor homolog 0.0073 0.0874 0.1397
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0038 0.0397 0.0394
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0131 0.0128
Onchocerca volvulus Protein ultraspiracle homolog 0.0073 0.0874 0.1397
Brugia malayi nuclear hormone receptor 0.0073 0.0874 0.0871
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0073 0.0874 0.0871
Plasmodium vivax SET domain protein, putative 0.0058 0.0667 0.7847
Echinococcus multilocularis bloom syndrome protein 0.0019 0.0131 0.0128
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0431 0.0428
Schistosoma mansoni calpain C (C02 family) 0.0021 0.0157 0.0465
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0157 0.1061
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0564 0.0561
Loa Loa (eye worm) RNA binding protein 0.0126 0.161 0.161
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0073 0.0874 0.0871
Onchocerca volvulus 0.0034 0.034 0.0541
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0157 0.1061
Echinococcus granulosus bloom syndrome protein 0.0019 0.0131 0.0128
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.161 0.1607
Onchocerca volvulus 0.005 0.0557 0.0888
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.0157 0.0465
Schistosoma mansoni hypothetical protein 0.0187 0.2458 0.7268
Loa Loa (eye worm) hypothetical protein 0.0034 0.034 0.034
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.085 0.1257
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0157 0.1852
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0371 0.5009 0.5009
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0075 0.09 0.0897
Mycobacterium ulcerans hypothetical protein 0.0071 0.085 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0564 0.0561
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0003 0.0003
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0102 0.0099
Echinococcus granulosus GPCR family 2 0.0117 0.1492 0.1489
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.085 0.0847
Schistosoma mansoni smad 0.0017 0.0102 0.0301
Loa Loa (eye worm) hypothetical protein 0.0038 0.0397 0.0397
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0157 0.1852
Schistosoma mansoni nuclear hormone receptor 0.0073 0.0874 0.2584
Brugia malayi nuclear receptor RXR 0.0034 0.034 0.0337
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.085 0.1257
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.085 0.1257
Schistosoma mansoni tar DNA-binding protein 0.0126 0.161 0.476
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0564 0.0564
Echinococcus multilocularis calpain 7 (C02 family) 0.0021 0.0157 0.0154
Schistosoma mansoni smad1 5 8 and 0.0017 0.0102 0.0301
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0404 0.5461 0.5461
Loa Loa (eye worm) hypothetical protein 0.0204 0.2696 0.2696
Schistosoma mansoni tar DNA-binding protein 0.0126 0.161 0.476
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.034 0.0337
Loa Loa (eye worm) hypothetical protein 0.0034 0.034 0.034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0073 0.0874 0.0874
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0015 0.0075 0.0115
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.085 0.2513
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0564 0.1668
Schistosoma mansoni smad1 5 8 and 0.0017 0.0102 0.0301
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0073 0.0874 0.0871
Brugia malayi latrophilin 2 splice variant baaae 0.0254 0.3381 0.3379
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0073 0.0874 0.2584
Trichomonas vaginalis esterase, putative 0.0071 0.085 0.1257
Loa Loa (eye worm) hypothetical protein 0.0019 0.0131 0.0131
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0431 0.0428
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0131 0.5
Loa Loa (eye worm) hypothetical protein 0.0073 0.0874 0.0874
Loa Loa (eye worm) beta-lactamase 0.0071 0.085 0.085
Brugia malayi Latrophilin receptor protein 2 0.0117 0.1492 0.1489
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0157 0.1852
Loa Loa (eye worm) hypothetical protein 0.0038 0.0397 0.0397
Schistosoma mansoni DNA helicase recq1 0.0019 0.0131 0.0387
Brugia malayi nuclear hormone receptor family member nhr-6 0.0034 0.034 0.0337
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.085 0.1257
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0073 0.0874 0.0871
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0131 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0073 0.0874 0.0871
Loa Loa (eye worm) hypothetical protein 0.0071 0.085 0.085
Brugia malayi nuclear receptor RXR 0.0038 0.0397 0.0394
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0667 0.1972
Schistosoma mansoni coup transcription factor 0.0073 0.0874 0.2584
Echinococcus granulosus ecdysone induced protein 78C 0.0073 0.0874 0.0871
Echinococcus multilocularis calpain 0.0021 0.0157 0.0154
Toxoplasma gondii hypothetical protein 0.001 0.0003 0.004
Brugia malayi beta-lactamase family protein 0.0071 0.085 0.0847
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0431 0.5074
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.0075 0.1745
Loa Loa (eye worm) hypothetical protein 0.0152 0.1974 0.1974
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0073 0.0874 0.2584
Loa Loa (eye worm) hypothetical protein 0.0034 0.034 0.034
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0131 0.0718
Loa Loa (eye worm) hypothetical protein 0.0038 0.0397 0.0397
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0073 0.0874 0.0871
Loa Loa (eye worm) hypothetical protein 0.0152 0.1974 0.1974
Echinococcus granulosus FTZ F1 alpha 0.0073 0.0874 0.0871
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0131 0.0128
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.034 0.0541
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0431 0.5074
Onchocerca volvulus 0.046 0.6235 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0557 0.0557
Schistosoma mansoni regulator of G protein signaling 0.001 0.0003 0.001
Treponema pallidum ATP-dependent DNA helicase 0.001 0.00000000011004 0.5
Schistosoma mansoni hypothetical protein 0.0117 0.1492 0.4412
Onchocerca volvulus 0.0149 0.1931 0.3094
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.0131 0.0128
Echinococcus granulosus thyroid hormone receptor alpha 0.0034 0.034 0.0337
Schistosoma mansoni RAR-like nuclear receptor 0.0073 0.0874 0.2584
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0073 0.0874 0.0871
Brugia malayi hypothetical protein 0.0034 0.034 0.0337
Brugia malayi Nuclear hormone receptor E75 0.0034 0.034 0.0337
Trypanosoma brucei kinesin, putative 0.0021 0.0157 0.1061
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.161 0.161
Echinococcus multilocularis Smad4 0.0017 0.0102 0.0099
Loa Loa (eye worm) hypothetical protein 0.0034 0.034 0.034
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0184 0.242 0.242
Loa Loa (eye worm) hypothetical protein 0.0073 0.0874 0.0874
Brugia malayi MH1 domain containing protein 0.0017 0.0102 0.0099
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0157 0.1852
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0131 0.154
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0073 0.0874 0.0871
Echinococcus multilocularis ecdysone induced protein 78C 0.0073 0.0874 0.0871
Loa Loa (eye worm) hypothetical protein 0.0034 0.034 0.034
Echinococcus multilocularis lysosomal alpha glucosidase 0.0184 0.242 0.2418
Echinococcus multilocularis hypothetical protein 0.0021 0.0157 0.0154
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0073 0.0874 0.0871
Loa Loa (eye worm) latrophilin receptor protein 2 0.0117 0.1492 0.1492
Loa Loa (eye worm) hypothetical protein 0.0034 0.034 0.034
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0073 0.0874 0.0871
Loa Loa (eye worm) hypothetical protein 0.0073 0.0874 0.0874
Loa Loa (eye worm) hypothetical protein 0.0034 0.034 0.034
Schistosoma mansoni calpain (C02 family) 0.0021 0.0157 0.0465
Brugia malayi nuclear receptor NHR-67 0.0034 0.034 0.0337
Loa Loa (eye worm) hypothetical protein 0.0073 0.0874 0.0874
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0157 0.1852
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0431 0.0431
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0073 0.0874 0.2584
Schistosoma mansoni alpha glucosidase 0.0041 0.0431 0.1275
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0073 0.0874 0.0871
Schistosoma mansoni alpha-glucosidase 0.0159 0.2064 0.6105
Brugia malayi Muscleblind-like protein 0.0152 0.1974 0.1972
Loa Loa (eye worm) calpain family protein 1 0.0071 0.085 0.085
Trichomonas vaginalis set domain proteins, putative 0.046 0.6235 1
Brugia malayi steroid hormone receptor 0.0073 0.0874 0.0871
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0157 0.1852
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.085 0.2513
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0131 0.0718
Loa Loa (eye worm) hypothetical protein 0.0071 0.085 0.085
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0117 0.1492 0.1489
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0073 0.0874 0.0874
Echinococcus multilocularis smad 0.0017 0.0102 0.0099
Loa Loa (eye worm) hypothetical protein 0.0071 0.085 0.085
Schistosoma mansoni smad1 5 8 and 0.0017 0.0102 0.0301
Brugia malayi conserved hypotetical protein 0.0034 0.034 0.0337
Onchocerca volvulus 0.0071 0.085 0.1358
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.085 0.0847
Mycobacterium ulcerans lipase LipD 0.0071 0.085 0.5
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0058 0.0667 0.0664
Schistosoma mansoni tar DNA-binding protein 0.0126 0.161 0.476
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0058 0.0667 0.0664
Brugia malayi photoreceptor-specific nuclear receptor 0.0073 0.0874 0.0871
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0431 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0075 0.09 0.2663
Brugia malayi Pre-SET motif family protein 0.0404 0.5461 0.546
Brugia malayi MH2 domain containing protein 0.0017 0.0102 0.0099
Loa Loa (eye worm) calpain 5 0.0021 0.0157 0.0157
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.085 0.5
Leishmania major kinesin, putative 0.0021 0.0157 0.1061
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0303 0.4058 0.4056
Onchocerca volvulus 0.0318 0.427 0.6846
Echinococcus multilocularis lysosomal alpha glucosidase 0.0184 0.242 0.2418
Echinococcus granulosus histone lysine methyltransferase setb 0.0058 0.0667 0.0664
Echinococcus granulosus calpain A 0.0075 0.09 0.0897
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.085 1
Schistosoma mansoni Smad4 0.0017 0.0102 0.0301
Schistosoma mansoni dep domain containing protein 0.001 0.0003 0.001
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0204 0.2696 0.4322
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0431 0.0578
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.085 0.0847
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0034 0.034 0.0337
Loa Loa (eye worm) hypothetical protein 0.0071 0.085 0.085
Brugia malayi beta-lactamase 0.0071 0.085 0.0847
Brugia malayi orphan nuclear receptor NR2E1 0.0034 0.034 0.0337
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0021 0.0157 0.1061
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0073 0.0874 0.0871
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0073 0.0874 0.2584
Schistosoma mansoni thyroid hormone receptor 0.0073 0.0874 0.2584
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0157 0.1852
Loa Loa (eye worm) hypothetical protein 0.0034 0.034 0.034
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0564 0.1668
Trypanosoma brucei glucosidase, putative 0.0041 0.0431 0.4596
Brugia malayi MH2 domain containing protein 0.0252 0.3356 0.3354
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0058 0.0667 0.7847
Loa Loa (eye worm) hypothetical protein 0.0034 0.034 0.034
Echinococcus granulosus smad 0.0017 0.0102 0.0099
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0075 0.0885
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0073 0.0874 0.0871
Echinococcus granulosus lysosomal alpha glucosidase 0.0184 0.242 0.2418
Loa Loa (eye worm) hypothetical protein 0.0073 0.0874 0.0874
Echinococcus multilocularis thyroid hormone receptor alpha 0.0073 0.0874 0.0871
Brugia malayi hypothetical protein 0.0038 0.0397 0.0394
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0157 0.1061
Loa Loa (eye worm) MH2 domain-containing protein 0.0252 0.3356 0.3356
Brugia malayi Smad1 0.0017 0.0102 0.0099
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0131 0.009
Loa Loa (eye worm) hypothetical protein 0.0556 0.7576 0.7576
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0073 0.0874 0.0871
Loa Loa (eye worm) hypothetical protein 0.0038 0.0397 0.0397
Brugia malayi Pre-SET motif family protein 0.0058 0.0667 0.0664
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0038 0.0397 0.1175
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0157 0.1061
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0038 0.0397 0.0394
Schistosoma mansoni nuclear hormone receptor 0.0034 0.034 0.1006
Onchocerca volvulus 0.0073 0.0874 0.1397
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.034 0.0337
Echinococcus multilocularis FTZ F1 alpha 0.0073 0.0874 0.0871
Mycobacterium leprae conserved hypothetical protein 0.0071 0.085 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.034 0.034
Schistosoma mansoni thyroid hormone receptor 0.0073 0.0874 0.2584
Toxoplasma gondii ABC1 family protein 0.0071 0.085 1
Schistosoma mansoni alpha-glucosidase 0.0159 0.2064 0.6105
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0073 0.0874 0.0871
Brugia malayi Nuclear hormone receptor E75 0.0034 0.034 0.0337
Echinococcus multilocularis geminin 0.0187 0.2458 0.2455
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0102 0.0301
Mycobacterium ulcerans beta-lactamase 0.0071 0.085 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.085 0.085
Echinococcus multilocularis nuclear receptor nhr 48 0.0034 0.034 0.0337
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0431 1
Onchocerca volvulus 0.0034 0.034 0.0541
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0075 0.09 0.0897
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0102 0.0102
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0117 0.1492 0.1489
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0131 0.009
Schistosoma mansoni nuclear hormone receptor 0.0034 0.034 0.1006
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0073 0.0874 0.0871
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0034 0.034 0.1006
Loa Loa (eye worm) hypothetical protein 0.0071 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0038 0.0397 0.0397
Brugia malayi Steroid receptor seven-up type 2 0.0073 0.0874 0.0871

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) = 275 nM Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production ChEMBL. 19782566

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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