Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0341 | 0.4517 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.0332 | 0.0332 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0152 | 0.1882 | 0.4317 |
Loa Loa (eye worm) | inositol-1 | 0.0041 | 0.0332 | 0.0735 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0321 | 0.4242 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0.0123 | 0.1374 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0041 | 0.0332 | 0.5 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0041 | 0.0332 | 0.0332 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0065 | 0.0662 | 0.0662 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.0662 | 0.1846 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0041 | 0.0332 | 0.0332 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0026 | 0.0123 | 0.008 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0321 | 0.4242 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0065 | 0.0662 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0251 | 0.3262 | 0.7223 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0059 | 0.0578 | 0.0578 |
Brugia malayi | RNA, U transporter 1 | 0.0091 | 0.1028 | 0.3152 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0059 | 0.0578 | 0.0578 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0089 | 0.5 |
Plasmodium falciparum | importin beta, putative | 0.0032 | 0.0207 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0041 | 0.0332 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0152 | 0.1882 | 0.4317 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0332 | 0.0584 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.0332 | 0.0332 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0024 | 0.0089 | 0.0089 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0032 | 0.0207 | 0.2052 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0024 | 0.0089 | 0.0089 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0041 | 0.0332 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0059 | 0.0578 | 0.0578 |
Mycobacterium ulcerans | hypothetical protein | 0.0169 | 0.2122 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0045 | 0.0392 | 0.0728 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0059 | 0.0578 | 0.1279 |
Brugia malayi | jmjC domain containing protein | 0.0059 | 0.0578 | 0.177 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0321 | 0.4242 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.0662 | 0.1846 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0089 | 0.0274 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.0662 | 0.1846 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0065 | 0.0662 | 0.0662 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0037 | 0.0272 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0055 | 0.0529 | 0.106 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0041 | 0.0332 | 0.4236 |
Echinococcus granulosus | importin subunit beta 1 | 0.0032 | 0.0207 | 0.0207 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0.0207 | 0.0283 |
Echinococcus granulosus | snurportin 1 | 0.0341 | 0.4517 | 0.4517 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0251 | 0.3262 | 0.7223 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0032 | 0.0207 | 0.0207 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0.0123 | 0.1374 |
Schistosoma mansoni | ran | 0.0024 | 0.0089 | 0.0089 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.0662 | 0.0662 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0045 | 0.0392 | 0.0728 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0169 | 0.2122 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0152 | 0.1882 | 0.4317 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0041 | 0.0332 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.0341 | 0.4517 | 0.4517 |
Brugia malayi | MH2 domain containing protein | 0.0251 | 0.3262 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0059 | 0.0578 | 0.0578 |
Trichomonas vaginalis | importin beta-1, putative | 0.0026 | 0.0123 | 0.1374 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0.0207 | 0.0283 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0332 | 0.0584 |
Leishmania major | importin beta-1 subunit, putative | 0.0026 | 0.0123 | 0.008 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0065 | 0.0662 | 0.138 |
Plasmodium vivax | importin-beta 2, putative | 0.0032 | 0.0207 | 1 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0045 | 0.0392 | 0.0728 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0207 | 0.0458 |
Entamoeba histolytica | hypothetical protein | 0.0026 | 0.0123 | 0.1374 |
Schistosoma mansoni | importin beta-1 | 0.0032 | 0.0207 | 0.0207 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0321 | 0.4242 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0059 | 0.0578 | 0.0578 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0332 | 0.0584 |
Brugia malayi | Importin beta-1 subunit | 0.0032 | 0.0207 | 0.0634 |
Toxoplasma gondii | hypothetical protein | 0.0052 | 0.0484 | 0.6891 |
Schistosoma mansoni | jumonji domain containing protein | 0.0059 | 0.0578 | 0.0578 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0065 | 0.0662 | 0.2109 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0089 | 0.0198 |
Schistosoma mansoni | hypothetical protein | 0.0341 | 0.4517 | 0.4517 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0332 | 0.0584 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.0662 | 0.0662 |
Brugia malayi | Inositol-1 | 0.0041 | 0.0332 | 0.1018 |
Brugia malayi | jmjC domain containing protein | 0.0059 | 0.0578 | 0.177 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0041 | 0.0332 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0045 | 0.0392 | 0.0728 |
Schistosoma mansoni | ran | 0.0024 | 0.0089 | 0.0089 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0059 | 0.0578 | 0.0578 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 19640709 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.