TDR Targets

Basic information

Technical information

TDR Targets ID: 1069968
Name: 3-(4-fluorophenyl)-8-azabicyclo[3.2.1]oct-3-e ne
MW: 203.255 | Formula: C13H14FN
H donors: 1 H acceptors: 0 LogP: 2.35 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)C1=CC2NC(C1)CC2
InChi: 1S/C13H14FN/c14-11-3-1-9(2-4-11)10-7-12-5-6-13(8-10)15-12/h1-4,7,12-13,15H,5-6,8H2
InChiKey: LKSXLNMBLGXHQS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Transporter	Starlite/ChEMBL	References
Rattus norvegicus	Dopamine transporter	Starlite/ChEMBL	References
Rattus norvegicus	Serotonin transporter	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Onchocerca volvulus		Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus granulosus	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	norepinephrine/norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	solute carrier family 6 member 4	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	sodium/chloride dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	IPR000175,Sodium:neurotransmitter symporter,domain-containing	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	serotonin transporter b	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus multilocularis	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Brugia malayi	Sodium:neurotransmitter symporter family protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent noradrenaline transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Treponema pallidum	sodium- and chloride- dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus	Transmembrane protein 120 homolog	Serotonin transporter	630 aa	571 aa	31.2 %
Brugia malayi	Sodium:neurotransmitter symporter family protein	Serotonin transporter	630 aa	576 aa	30.9 %
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	Serotonin transporter	630 aa	582 aa	35.2 %
Plasmodium vivax	hypothetical protein, conserved	Serotonin transporter	630 aa	528 aa	21.2 %
Onchocerca volvulus		Transporter	617 aa	586 aa	37.4 %
Schistosoma mansoni	sodium/chloride dependent transporter	Serotonin transporter	630 aa	605 aa	37.7 %
Schistosoma japonicum	ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative	Serotonin transporter	630 aa	520 aa	36.2 %
Onchocerca volvulus		Serotonin transporter	630 aa	611 aa	26.4 %
Neospora caninum	sodium-dependent transporter, putative	Dopamine transporter	619 aa	498 aa	32.3 %
Onchocerca volvulus	High affinity copper uptake protein 1 homolog	Serotonin transporter	630 aa	629 aa	47.1 %
Plasmodium falciparum	transporter, putative	Transporter	617 aa	497 aa	21.5 %
Drosophila melanogaster	CG13796 gene product from transcript CG13796-RD	Serotonin transporter	630 aa	638 aa	25.1 %
Echinococcus multilocularis	sodium and chloride dependent glycine	Transporter	617 aa	507 aa	38.9 %
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	Transporter	617 aa	522 aa	22.0 %
Echinococcus granulosus	sodium and chloride dependent glycine	Serotonin transporter	630 aa	617 aa	39.4 %
Plasmodium knowlesi	transporter, putative	Serotonin transporter	630 aa	514 aa	20.2 %
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	Serotonin transporter	630 aa	509 aa	28.3 %
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	Dopamine transporter	619 aa	604 aa	37.9 %
Drosophila melanogaster	CG1698 gene product from transcript CG1698-RA	Serotonin transporter	630 aa	585 aa	34.2 %
Echinococcus multilocularis	sodium and chloride dependent glycine	Serotonin transporter	630 aa	617 aa	39.4 %
Echinococcus granulosus	sodium and chloride dependent glycine	Transporter	617 aa	507 aa	38.9 %
Schistosoma japonicum	ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative	Serotonin transporter	630 aa	581 aa	40.1 %
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	Serotonin transporter	630 aa	576 aa	31.8 %
Schistosoma mansoni	sodium/chloride dependent transporter	Serotonin transporter	630 aa	552 aa	41.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cysteine peptidase, putative	0.0141	0.3811	0.3719
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0045	0.067	0.0385
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0784	0.0894
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0037	0.0401	0.0499
Leishmania major	cathepsin L-like protease	0.0037	0.0401	0.01
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.005	0.0814	0.8637
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0061	0.1188	0.1337
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0041	0.052	0.0646
Loa Loa (eye worm)	fibroinase	0.0037	0.0401	0.0458
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0038	0.0432	0.0473
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.0814	0.0928
Schistosoma mansoni	sex comb on midleg homolog	0.0054	0.0945	0.0945
Trypanosoma brucei	DNA polymerase eta, putative	0.0061	0.1203	0.1195
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0037	0.0401	0.0499
Schistosoma mansoni	sex comb on midleg homolog	0.0054	0.0945	0.0945
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0432	0.0399
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0183	0.519	0.5912
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.005	0.0814	0.8637
Loa Loa (eye worm)	ctsf protein	0.0037	0.0401	0.0458
Onchocerca volvulus		0.0166	0.462	0.527
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0321	0.9728	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0432	0.0399
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0307	0.0382
Echinococcus granulosus	dna polymerase eta	0.0061	0.1203	0.1372
Onchocerca volvulus	Cathepsin F homolog	0.0037	0.0401	0.0458
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0401	0.0499
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0054	0.0945	0.1059
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.3811	0.3889
Schistosoma mansoni	alpha-glucosidase	0.0157	0.4354	0.4354
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0061	0.1188	0.1188
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0401	0.0499
Brugia malayi	Cathepsin L-like precursor	0.0037	0.0401	0.0458
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0401	0.0499
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0025	0.0018	0.0018
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.3811	0.3889
Brugia malayi	follicle stimulating hormone receptor	0.026	0.772	0.8806
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.005	0.0814	0.0909
Onchocerca volvulus		0.005	0.0814	0.0928
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0152	0.4176	0.4107
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0401	0.0499
Trypanosoma brucei	unspecified product	0.0038	0.0432	0.0399
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0038	0.0432	0.0493
Leishmania major	cathepsin L-like protease	0.0141	0.3811	0.3719
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0037	0.0401	0.0458
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.027	0.8037	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0784	0.0784
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0041	0.052	0.0646
Onchocerca volvulus		0.0292	0.8767	1
Schistosoma mansoni	bromodomain containing protein	0.0071	0.1519	0.1519
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.3811	0.3889
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0432	0.0399
Schistosoma mansoni	sodium-dependent amino acid transporter	0.005	0.0814	0.0814
Echinococcus multilocularis	dna polymerase eta	0.0061	0.1203	0.1355
Leishmania major	cathepsin L-like protease	0.0037	0.0401	0.01
Brugia malayi	hypothetical protein	0.005	0.0814	0.0928
Trypanosoma cruzi	cruzipain precursor, putative	0.0141	0.3811	0.3719
Trypanosoma cruzi	cysteine peptidase, putative	0.0037	0.0401	0.01
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0784	0.0784
Leishmania major	DNA polymerase kappa, putative	0.0038	0.0432	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0292	0.8767	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.027	0.8037	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0037	0.0401	0.0499
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.3811	0.3889
Entamoeba histolytica	cysteine proteinase, putative	0.0037	0.0401	0.0499
Brugia malayi	ImpB/MucB/SamB family protein	0.0061	0.1203	0.1372
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0432	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0759	0.0866
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0054	0.0945	0.0945
Trichomonas vaginalis	alpha-glucosidase, putative	0.0041	0.052	0.0646
Echinococcus granulosus	serotonin transporter	0.0292	0.8767	1
Plasmodium falciparum	amino acid transporter, putative	0.005	0.0814	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.0814	0.0928
Echinococcus multilocularis	cathepsin L cysteine protease	0.0037	0.0401	0.0438
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0401	0.0499
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0432	0.0399
Onchocerca volvulus		0.0037	0.0401	0.0458
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0401	0.0499
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.027	0.8037	1
Trypanosoma brucei	glucosidase, putative	0.0041	0.052	0.0489
Loa Loa (eye worm)	hypothetical protein	0.005	0.0814	0.0928
Onchocerca volvulus		0.005	0.0814	0.0928
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0215	0.6242	0.7115
Loa Loa (eye worm)	hypothetical protein	0.005	0.0814	0.0928
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.027	0.8037	1
Echinococcus granulosus	fetal alzheimer antigen falz	0.0025	0.0018	0.0021
Leishmania major	cathepsin L-like protease	0.0037	0.0401	0.01
Echinococcus multilocularis	cathepsin L cysteine protease	0.0037	0.0401	0.0438
Trichomonas vaginalis	DNA polymerase eta, putative	0.0038	0.0432	0.0537
Loa Loa (eye worm)	hypothetical protein	0.005	0.0814	0.0928
Leishmania major	mitochondrial DNA polymerase beta	0.0321	0.9728	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0037	0.0401	0.0438
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.005	0.0814	0.0814
Leishmania major	cathepsin L-like protease	0.0037	0.0401	0.01
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0401	0.0499
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.052	0.0225
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0034	0.0307	0.0382
Toxoplasma gondii	hypothetical protein	0.0052	0.0888	1
Echinococcus granulosus	sodium and chloride dependent glycine	0.005	0.0814	0.0928
Brugia malayi	Cathepsin L-like precursor	0.0037	0.0401	0.0458
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0041	0.052	0.0573
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0183	0.519	0.592
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.005	0.0814	0.0928
Leishmania major	alpha glucosidase II subunit, putative	0.0041	0.052	0.0225
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.027	0.8037	1
Schistosoma mansoni	alpha glucosidase	0.0041	0.052	0.052
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0401	0.0499
Echinococcus multilocularis	ubiquitin specific protease 41	0.0034	0.0307	0.0331
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0401	0.0499
Trypanosoma brucei	DNA polymerase IV, putative	0.0038	0.0432	0.0399
Leishmania major	cathepsin L-like protease	0.0141	0.3811	0.3719
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0401	0.0499
Brugia malayi	Bromodomain containing protein	0.0084	0.1951	0.2225
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.0814	0.0814
Leishmania major	DNA polymerase eta, putative	0.0035	0.0345	0.004
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0045	0.067	0.0385
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.005	0.0814	0.0928
Onchocerca volvulus		0.0037	0.0401	0.0458
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.026	0.772	0.8806
Trypanosoma cruzi	DNA polymerase eta, putative	0.0035	0.0345	0.004
Echinococcus granulosus	sodium and chloride dependent glycine	0.005	0.0814	0.0928
Loa Loa (eye worm)	hypothetical protein	0.005	0.0814	0.0928
Entamoeba histolytica	cysteine proteinase, putative	0.0037	0.0401	0.0499
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.005	0.0814	0.0928
Leishmania major	DNA polymerase eta, putative	0.0061	0.1203	0.0951
Echinococcus granulosus	histone acetyltransferase MYST2	0.0061	0.1188	0.1355
Schistosoma mansoni	cathepsin F (C01 family)	0.0037	0.0401	0.0401
Leishmania major	cathepsin L-like protease	0.0141	0.3811	0.3719
Loa Loa (eye worm)	hypothetical protein	0.0061	0.1203	0.1372
Entamoeba histolytica	cysteine protease, putative	0.0037	0.0401	0.0499
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0183	0.519	0.5912
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.005	0.0814	0.5
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0183	0.519	0.592
Onchocerca volvulus		0.0037	0.0401	0.0458
Loa Loa (eye worm)	hypothetical protein	0.005	0.0814	0.0928
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0038	0.0432	0.0537
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0045	0.067	0.0385
Trichomonas vaginalis	alpha-glucosidase, putative	0.0041	0.052	0.0646
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0132	0.3511	0.7147
Onchocerca volvulus		0.005	0.0814	0.0928
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0321	0.9728	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0601	0.0686
Echinococcus granulosus	SAM and MBT domain containing protein	0.0054	0.0945	0.1078
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0784	0.0784
Trichomonas vaginalis	alpha-glucosidase, putative	0.0041	0.052	0.0646
Brugia malayi	Cathepsin L-like precursor	0.0037	0.0401	0.0458
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0041	0.052	0.0646
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0041	0.052	0.0593
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0041	0.052	0.0593
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.005	0.0814	0.0928
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1793	0.2045
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0038	0.0432	0.0432
Loa Loa (eye worm)	norepinephrine transporter	0.0292	0.8767	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0038	0.0432	0.0132
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.3811	0.3889
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0307	0.0351
Loa Loa (eye worm)	serotonin transporter b	0.0292	0.8767	1
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0034	0.0307	0.0307
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0041	0.052	0.3215
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0041	0.052	0.0646
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0067	0.1387	0.1565
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.0784	0.0894
Schistosoma mansoni	sodium/chloride dependent transporter	0.0292	0.8767	0.8767
Giardia lamblia	Fructose-bisphosphate aldolase	0.027	0.8037	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.0784	0.0894
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.027	0.8037	1
Echinococcus granulosus	dna polymerase kappa	0.0038	0.0432	0.0493
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0037	0.0401	0.0499
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0784	0.0875
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.0814	0.0814
Brugia malayi	Cathepsin L-like precursor	0.0037	0.0401	0.0458
Schistosoma mansoni	DNA polymerase eta	0.0061	0.1203	0.1203
Loa Loa (eye worm)	hypothetical protein	0.005	0.0814	0.0928
Echinococcus multilocularis	polycomb protein SCMH1	0.0054	0.0945	0.1059
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0401	0.0499
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0061	0.1188	0.1355
Loa Loa (eye worm)	hypothetical protein	0.005	0.0814	0.0928
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0037	0.0401	0.0438
Plasmodium vivax	hypothetical protein, conserved	0.005	0.0814	1
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0054	0.0945	0.1078
Trypanosoma brucei	DNA polymerase IV, putative	0.0038	0.0432	0.0399
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.005	0.0814	0.0909
Brugia malayi	mbt repeat family protein	0.0054	0.0945	0.1078
Giardia lamblia	DINP protein human, muc B family	0.0038	0.0432	0.0161
Trypanosoma cruzi	cysteine peptidase, putative	0.0141	0.3811	0.3719
Brugia malayi	Bromodomain containing protein	0.0043	0.0599	0.0683
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.3811	0.3889
Echinococcus multilocularis	sodium and chloride dependent glycine	0.005	0.0814	0.0909
Echinococcus granulosus	cathepsin l1	0.0037	0.0401	0.0458
Trypanosoma cruzi	DNA polymerase eta, putative	0.0061	0.1203	0.0951
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0152	0.4176	0.4107
Loa Loa (eye worm)	hypothetical protein	0.0292	0.8767	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0037	0.0401	0.0499
Toxoplasma gondii	cathepsin CPL	0.0037	0.0401	0.1032
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0401	0.0499
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0432	0.0399
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0067	0.1387	0.1582
Echinococcus granulosus	polycomb protein SCMH1	0.0054	0.0945	0.1078
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0038	0.0432	0.0537
Schistosoma mansoni	alpha-glucosidase	0.0157	0.4354	0.4354
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0132	0.3511	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0037	0.0401	0.0499
Trichomonas vaginalis	alpha-glucosidase, putative	0.0041	0.052	0.0646
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.0814	0.0814
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0041	0.052	0.0646
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0034	0.0307	0.0382
Loa Loa (eye worm)	cysteine protease	0.0037	0.0401	0.0458
Brugia malayi	ImpB/MucB/SamB family protein	0.0038	0.0432	0.0493
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0034	0.0307	0.0382
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0292	0.8767	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0055	0.0994	0.0729
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.005	0.0814	0.0814
Toxoplasma gondii	hypothetical protein	0.005	0.0814	0.8637
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0432	0.0399
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0034	0.0307	0.0307
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0432	0.0399
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0037	0.0401	0.0458
Schistosoma mansoni	cathepsin F (C01 family)	0.0037	0.0401	0.0401
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0401	0.0458
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.027	0.8037	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0037	0.0401	0.0499
Brugia malayi	Papain family cysteine protease containing protein	0.0037	0.0401	0.0458
Mycobacterium ulcerans	hypothetical protein	0.0169	0.474	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0111	0.2821	0.2669
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.005	0.0814	0.8637
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0292	0.8767	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0038	0.0432	0.0132
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0037	0.0401	0.0458
Echinococcus multilocularis	sodium and chloride dependent glycine	0.005	0.0814	0.0909
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.027	0.8037	1
Loa Loa (eye worm)	mbt repeat family protein	0.0054	0.0945	0.1078
Trypanosoma brucei	DNA polymerase IV, putative	0.0038	0.0432	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0061	0.1188	0.1355
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0432	0.0399
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.3811	0.3889
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0321	0.9728	1
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0034	0.0307	0.027
Loa Loa (eye worm)	MBCTL1	0.0061	0.1188	0.1355
Onchocerca volvulus		0.0037	0.0401	0.0458
Echinococcus multilocularis	serotonin transporter	0.0292	0.8767	1
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0132	0.3511	0.7147
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0152	0.4176	0.4266
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0038	0.0432	0.0493
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.0814	0.0814
Echinococcus granulosus	neutral alpha glucosidase AB	0.0041	0.052	0.0593
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0037	0.0401	0.0499
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0034	0.0307	0.0351
Brugia malayi	PHD-finger family protein	0.0028	0.0105	0.012
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0038	0.0432	0.0132
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0169	0.474	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0041	0.052	0.0646
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0784	0.0894
Onchocerca volvulus		0.0037	0.0401	0.0458
Echinococcus granulosus	lysosomal alpha glucosidase	0.0183	0.519	0.592
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.005	0.0814	0.0909
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0034	0.0307	0.0351
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.005	0.0814	0.0928
Onchocerca volvulus		0.0037	0.0401	0.0458
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.3811	0.3889
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.0814	0.0814
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0037	0.0401	0.0458
Onchocerca volvulus	Cathepsin L homolog	0.0037	0.0401	0.0458
Onchocerca volvulus		0.0054	0.0945	0.1078
Brugia malayi	Cathepsin L-like precursor	0.0037	0.0401	0.0458
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0061	0.1188	0.1355
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0034	0.0307	0.0331
Onchocerca volvulus		0.0106	0.2659	0.3033
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0038	0.0432	0.0132
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.3811	0.3889
Echinococcus multilocularis	cysteine protease	0.0037	0.0401	0.0438
Schistosoma mansoni	sodium/chloride dependent transporter	0.005	0.0814	0.0814
Plasmodium vivax	amine transporter, putative	0.005	0.0814	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.004	0.0511	0.0583
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.0814	0.0928
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.005	0.0814	0.0928
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0034	0.0307	0.0331
Onchocerca volvulus		0.0037	0.0401	0.0458
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.005	0.0814	0.0928
Toxoplasma gondii	hypothetical protein	0.005	0.0814	0.8637
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.3811	0.3889
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0037	0.0401	0.0499
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0034	0.0307	0.0351
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0432	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0292	0.8767	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0784	0.0875
Echinococcus multilocularis	dna polymerase kappa	0.0038	0.0432	0.0473
Brugia malayi	hypothetical protein	0.0166	0.462	0.527
Treponema pallidum	sodium- and chloride- dependent transporter	0.0292	0.8767	1
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.027	0.8037	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0038	0.0432	0.0132
Leishmania major	cysteine peptidase A (CPA)	0.0037	0.0401	0.01
Brugia malayi	Cathepsin L-like precursor	0.0037	0.0401	0.0458
Schistosoma mansoni	sodium/chloride dependent transporter	0.005	0.0814	0.0814
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0129	0.341	0.3293
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.3811	0.3889
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0945	0.1078
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0401	0.0499
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0045	0.067	0.0645
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0401	0.0499
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0292	0.8767	0.8767
Loa Loa (eye worm)	hypothetical protein	0.0166	0.462	0.527
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0061	0.1188	0.1337
Echinococcus multilocularis	cysteine protease	0.0037	0.0401	0.0438
Trypanosoma cruzi	cysteine peptidase, putative	0.0141	0.3811	0.3719
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0038	0.0432	0.0432
Plasmodium falciparum	transporter, putative	0.005	0.0814	1
Echinococcus granulosus	ubiquitin specific protease 41	0.0034	0.0307	0.0351
Onchocerca volvulus	Cathepsin L homolog	0.0037	0.0401	0.0458
Brugia malayi	mbt repeat family protein	0.0054	0.0945	0.1078
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.004	0.0511	0.0564
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.027	0.8037	1
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0215	0.6242	0.7121
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.052	0.0225
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0041	0.052	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0688	0.0785
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0037	0.0401	0.0499
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0037	0.0401	0.0499
Leishmania major	cathepsin L-like protease	0.0037	0.0401	0.01

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 129 nM	Displacement of [3H]citalopram from SERT in rat brain	ChEMBL.	19896846
Ki (binding)	= 1056 nM	Displacement of [3H]WIN-35428 from DAT in rat brain	ChEMBL.	19896846
Ki (binding)	= 1989 nM	Displacement of [3H]nisoxetine from NET in rat brain	ChEMBL.	19896846

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL570638

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1069968