Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0518 | 0.9249 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0112 | 0.1687 | 0.1656 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.0777 | 0.0415 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0629 | 0.3729 |
Schistosoma mansoni | single-minded | 0.0059 | 0.0694 | 0.4116 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0602 | 0.1841 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0296 | 0.026 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0043 | 0.041 | 0.0374 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0629 | 0.0594 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0629 | 0.1923 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0094 | 0.1355 | 0.3981 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0037 | 0.0219 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0094 | 0.1355 | 0.3981 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0629 | 0.3729 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0112 | 0.1687 | 0.5 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0249 | 0.4241 | 0.4539 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0518 | 0.9249 | 1 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0094 | 0.1355 | 0.3981 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0112 | 0.1687 | 0.1754 |
Schistosoma mansoni | bromodomain containing protein | 0.0066 | 0.0826 | 0.49 |
Giardia lamblia | DNA topoisomerase II | 0.0104 | 0.1541 | 0.5 |
Brugia malayi | bHLH-PAS transcription factor | 0.0043 | 0.041 | 0.1038 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0112 | 0.1687 | 1 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0518 | 0.9249 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0296 | 0.026 |
Brugia malayi | hypothetical protein | 0.0197 | 0.3271 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0063 | 0.0777 | 0.0743 |
Brugia malayi | Probable DNA topoisomerase II | 0.0112 | 0.1687 | 0.5038 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0063 | 0.0777 | 0.2179 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0112 | 0.1687 | 0.1754 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0112 | 0.1687 | 0.5038 |
Echinococcus granulosus | single minded 2 | 0.0043 | 0.041 | 0.0374 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.3271 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0629 | 0.0594 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0078 | 0.024 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0971 | 0.2968 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0629 | 0.1724 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0198 | 0.3284 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0198 | 0.3284 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.039 | 0.1191 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0112 | 0.1687 | 0.1754 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0163 | 0.2643 | 0.2834 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0112 | 0.1687 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.0777 | 0.4606 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0182 | 0.2986 | 0.9131 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0518 | 0.9249 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0427 | 0.1304 |
Schistosoma mansoni | DNA topoisomerase II | 0.0112 | 0.1687 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0249 | 0.4241 | 0.4334 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0247 | 0.42 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0062 | 0.0757 | 0.0723 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0518 | 0.9249 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0518 | 0.9249 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0602 | 0.1841 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.0777 | 0.0415 |
Brugia malayi | PHD-finger family protein | 0.0026 | 0.0083 | 0.0014 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.0777 | 0.0415 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.0777 | 0.4606 |
Brugia malayi | hypoxia-induced factor 1 | 0.0182 | 0.2986 | 0.9109 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0344 | 0.1051 |
Leishmania major | DNA topoisomerase ii | 0.0094 | 0.1355 | 0.3981 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0249 | 0.4241 | 0.4539 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0198 | 0.3284 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0112 | 0.1687 | 0.1656 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0059 | 0.0694 | 0.4116 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0629 | 0.3729 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0063 | 0.0777 | 0.0762 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0629 | 0.0594 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0629 | 0.0594 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0054 | 0.0602 | 0.062 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0518 | 0.9249 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0249 | 0.4241 | 0.4089 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0112 | 0.1687 | 0.5038 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0518 | 0.9249 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0198 | 0.3284 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0249 | 0.4241 | 0.4568 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0112 | 0.1687 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0094 | 0.1355 | 0.3981 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0112 | 0.1687 | 0.5157 |
Brugia malayi | Bromodomain containing protein | 0.004 | 0.0342 | 0.0827 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0144 | 0.2282 | 0.2403 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0063 | 0.0777 | 0.0743 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0062 | 0.0757 | 0.0723 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0353 | 0.1079 |
Brugia malayi | PAS domain containing protein | 0.0059 | 0.0694 | 0.1929 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0353 | 0.1079 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0112 | 0.1687 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0078 | 0.1054 | 0.3055 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.