Detailed information for compound 1070179

Basic information

Technical information
  • TDR Targets ID: 1070179
  • Name: N-[4-(diaminomethylideneamino)butyl]-3-(4-hyd roxyphenyl)prop-2-enamide
  • MW: 276.334 | Formula: C14H20N4O2
  • H donors: 4 H acceptors: 2 LogP: 0.81 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(/C=C/c1ccc(cc1)O)NCCCCNC(=N)N
  • InChi: 1S/C14H20N4O2/c15-14(16)18-10-2-1-9-17-13(20)8-5-11-3-6-12(19)7-4-11/h3-8,19H,1-2,9-10H2,(H,17,20)(H4,15,16,18)/b8-5+
  • InChiKey: AKIHYQWCLCDMMI-VMPITWQZSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (E)-N-[4-(diaminomethylideneamino)butyl]-3-(4-hydroxyphenyl)prop-2-enamide
  • (E)-N-(4-guanidinobutyl)-3-(4-hydroxyphenyl)prop-2-enamide
  • N-(4-guanidinobutyl)-3-(4-hydroxyphenyl)prop-2-enamide
  • (E)-N-(4-guanidinobutyl)-3-(4-hydroxyphenyl)acrylamide
  • N-(4-guanidinobutyl)-3-(4-hydroxyphenyl)acrylamide
  • C04498
  • N-(4-Guanidinobutyl)-4-hydroxycinnamide
  • CHEBI:32818
  • N-(4-guanidinobutyl)-4-hydroxycinnamamide
  • N-(4-guanidinobutyl)-N(4)-hydroxycinnamamide
  • N-[4-(carbamimidamido)butyl]-3-(4-hydroxyphenyl)prop-2-enamide
  • coumarylagmatine
  • p-coumarylagmatine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0019 0.0016 0.0713
Loa Loa (eye worm) G protein alpha subunit 3 0.0013 0.0002 0.0018
Brugia malayi MH1 domain containing protein 0.0014 0.0005 0.003
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.002 0.0352
Brugia malayi serine/threonine-protein kinase plk-2 0.0099 0.0193 0.1711
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Brugia malayi MH1 domain containing protein 0.0014 0.0005 0.003
Schistosoma mansoni cpg binding protein 0.01 0.0197 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0105 0.0207 0.1837
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0181
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0363 0.6401
Echinococcus multilocularis lamin 0.0028 0.0036 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.002 0.0164
Schistosoma mansoni lamin 0.0028 0.0036 0.0034
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0021 0.0378
Onchocerca volvulus 0.0028 0.0036 0.0661
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0082 0.1453
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Onchocerca volvulus 0.0021 0.002 0.0352
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0013 0.0002 0.0035
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.002 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.002 0.0018
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0031 0.0029
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0298 0.0636 0.0634
Schistosoma mansoni smad1 5 8 and 0.0026 0.0031 0.0029
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0013 0.0002 0.0035
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.002 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0298 0.0636 0.0634
Plasmodium vivax SET domain protein, putative 0.0033 0.0047 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0004 0.0002
Schistosoma mansoni cpg binding protein 0.0095 0.0185 0.0183
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.002 0.0018
Trichomonas vaginalis set domain proteins, putative 0.0247 0.0522 0.9215
Loa Loa (eye worm) hypothetical protein 0.0033 0.0047 0.0417
Brugia malayi nuclear hormone receptor 0.0021 0.002 0.0164
Schistosoma mansoni cpg binding protein 0.01 0.0197 0.0195
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0013 0.0002 0.0035
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.0456 0.4072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.002 0.0181
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0013 0.0002 0.0035
Schistosoma mansoni smad1 5 8 and 0.0026 0.0031 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0016 0.014
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.002 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0193 0.3411
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0013 0.0002 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0021 0.0378
Brugia malayi MH2 domain containing protein 0.038 0.0818 0.7298
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0298 0.0636 0.0634
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0023 0.0429
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0021 0.0378
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0031 0.0029
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.002 0.0018
Schistosoma mansoni thyroid hormone receptor 0.0021 0.002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0018
Schistosoma mansoni coup transcription factor 0.0021 0.002 0.0018
Schistosoma mansoni lamin 0.0028 0.0036 0.0034
Loa Loa (eye worm) histone methyltransferase 0.0031 0.0041 0.037
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.002 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0363 0.6401
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.002 0.0181
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0031 0.0278
Echinococcus granulosus survival motor neuron protein 1 0.0516 0.1121 0.1119
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0567 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0021 0.0378
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.045 0.0974 0.5
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.2003 0.443 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0021 0.0378
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.0016 0.0809
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0181
Loa Loa (eye worm) Smad1 0.0026 0.0031 0.0278
Schistosoma mansoni survival motor neuron protein 0.0105 0.0207 0.0206
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0384 0.6771
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0193 0.3411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.002 0.0164
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0031 0.0029
Treponema pallidum replicative DNA helicase (dnaB) 0.045 0.0974 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0567 1
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0567 1
Mycobacterium leprae Conserved hypothetical protein 0.059 0.1285 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.002 0.0018
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.002 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.002 0.0164
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.002 0.0018
Schistosoma mansoni hypothetical protein 0.0104 0.0204 0.0202
Entamoeba histolytica serine/threonine protein kinase, putative 0.0099 0.0193 1
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0567 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.002 0.0164
Loa Loa (eye worm) twinkle helicase 0.0129 0.0259 0.2316
Loa Loa (eye worm) hypothetical protein 0.0022 0.0023 0.0208
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0016 0.0014
Brugia malayi intermediate filament protein 0.0028 0.0036 0.0307
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0025 0.0029 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0021 0.0378
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0016 0.0122
Echinococcus granulosus dnaJ subfamily B 0.0877 0.1925 0.1923
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0013 0.0002 0.0018
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.0193 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0007 0.0064
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.0031 0.0029
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0031 0.0278
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.0016 0.0809
Echinococcus multilocularis cpg binding protein 0.01 0.0197 0.0195
Schistosoma mansoni kinase 0.005 0.0085 0.0083
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.002 0.0018
Echinococcus granulosus intermediate filament protein 0.0028 0.0036 0.0034
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0099 0.0193 0.1726
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0047 0.0045
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0193 0.3411
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.002 0.0181
Brugia malayi Pre-SET motif family protein 0.0217 0.0456 0.4062
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0026 0.0031 0.1622
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0384 0.6771
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0047 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0104 0.0204 0.1809
Onchocerca volvulus Serine\/threonine kinase homolog 0.0099 0.0193 0.3678
Trichomonas vaginalis helicase, putative 0.0022 0.0021 0.0378
Brugia malayi steroid hormone receptor 0.0021 0.002 0.0164
Toxoplasma gondii histone lysine methyltransferase SET1 0.0181 0.0377 1
Echinococcus granulosus neuropeptide receptor A26 0.2067 0.4573 0.4572
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Loa Loa (eye worm) latrophilin receptor protein 2 0.0104 0.0204 0.1823
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.002 0.0164
Mycobacterium ulcerans replicative DNA helicase DnaB 0.045 0.0974 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0363 0.6401
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0567 1
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0036 0.0307
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0021 0.0378
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0021 0.0378
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0004 0.0002
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.002 0.0352
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.002 0.0018
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.002 0.0018
Toxoplasma gondii FATC domain-containing protein 0.0026 0.0031 0.0833
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.002 0.0018
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0013 0.0002 0.0035
Loa Loa (eye worm) MH2 domain-containing protein 0.038 0.0818 0.7303
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0013 0.0002 0.0018
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0016 0.0122
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0019 0.0016 0.0713
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0298 0.0636 0.0634
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Schistosoma mansoni hypothetical protein 0.0105 0.0207 0.0206
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0036 0.0325
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0021 0.0378
Echinococcus multilocularis survival motor neuron protein 1 0.0516 0.1121 0.1119
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0016 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0047 0.0045
Schistosoma mansoni hypothetical protein 0.0397 0.0858 0.0856
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0193 0.3411
Entamoeba histolytica hypothetical protein 0.0026 0.0031 0.1535
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0298 0.0636 0.0634
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0082 0.1453
Echinococcus granulosus Smad4 0.0026 0.0031 0.0029
Echinococcus granulosus mixed lineage leukemia protein mll 0.0025 0.0029 0.0027
Brugia malayi Calcitonin receptor-like protein seb-1 0.0328 0.0703 0.6265
Schistosoma mansoni thyroid hormone receptor 0.0021 0.002 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.002 0.0018
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.002 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0363 0.6401
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0016 0.0014
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0104 0.0204 0.0202
Loa Loa (eye worm) hypothetical protein 0.0028 0.0035 0.0314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Echinococcus granulosus smad 0.0026 0.0031 0.0029
Brugia malayi CXXC zinc finger family protein 0.0095 0.0185 0.1636
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.002 0.0018
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0013 0.0002 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.002 0.0181
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0181
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.0016 0.0809
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0021 0.0378
Echinococcus granulosus geminin 0.0397 0.0858 0.0856
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0193 0.3411
Onchocerca volvulus 0.0033 0.0047 0.086
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0298 0.0636 0.5672
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0041 0.0346
Chlamydia trachomatis replicative DNA helicase 0.045 0.0974 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0016 0.014
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.002 0.0164
Echinococcus multilocularis neuropeptide s receptor 0.2067 0.4573 0.4572
Brugia malayi Pre-SET motif family protein 0.0033 0.0047 0.04
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0021 0.0378
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.002 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.002 0.0164
Echinococcus multilocularis lamin dm0 0.0028 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0181
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0016 0.0005
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0025 0.0029 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0099 0.0193 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.004 0.0038
Echinococcus multilocularis musashi 0.0028 0.0036 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0021 0.0378
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1719 0.3799 0.3797
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.002 0.0018
Echinococcus granulosus GPCR family 2 0.0104 0.0204 0.0202
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0021 0.0378
Brugia malayi latrophilin 2 splice variant baaae 0.0224 0.0472 0.4202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Loa Loa (eye worm) hypothetical protein 0.0516 0.1121 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0021 0.0378
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0021 0.0378
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0104 0.0204 0.0202
Brugia malayi MH1 domain containing protein 0.0026 0.0031 0.026
Brugia malayi hypothetical protein 0.0516 0.1121 1
Loa Loa (eye worm) hypothetical protein 0.0328 0.0703 0.6272
Schistosoma mansoni Smad4 0.0026 0.0031 0.0029
Echinococcus multilocularis geminin 0.0397 0.0858 0.0856
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.002 0.0164
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.002 0.0018
Echinococcus granulosus lamin dm0 0.0028 0.0036 0.0034
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.0031 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0193 0.3411
Onchocerca volvulus 0.0095 0.0185 0.3516
Giardia lamblia Kinase, PLK 0.0099 0.0193 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0328 0.0703 0.6265
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0016 0.0014
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0024
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0047 0.1241
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0031 0.0041 0.0039
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.002 0.0181
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0047 0.0045
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0104 0.0204 0.0202
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0363 0.6401
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0104 0.0204 0.0202
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0035
Brugia malayi Latrophilin receptor protein 2 0.0104 0.0204 0.1809
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0013 0.0002 0.0018
Echinococcus granulosus FTZ F1 alpha 0.0021 0.002 0.0018
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0298 0.0636 0.5664
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0047 0.0045
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0298 0.0636 0.0634
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.002 0.0164
Loa Loa (eye worm) CXXC zinc finger family protein 0.0095 0.0185 0.1651
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0181
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0031 0.0263
Onchocerca volvulus 0.0105 0.0207 0.3949
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0031 0.0884
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0031 0.0041 0.0039
Echinococcus multilocularis neuropeptide receptor A26 0.2067 0.4573 0.4572
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0031 0.0029
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0006 0.0004
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0099 0.0193 0.0191
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.0016 0.0809
Schistosoma mansoni smad1 5 8 and 0.0026 0.0031 0.0029
Echinococcus granulosus serine protein kinase ATM 0.0026 0.0031 0.0029
Brugia malayi Smad1 0.0026 0.0031 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0021 0.0378
Echinococcus granulosus neuropeptide s receptor 0.2067 0.4573 0.4572
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.002 0.0164
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0016 0.0415
Echinococcus granulosus cpg binding protein 0.01 0.0197 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.002 0.0164
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.002 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0193 0.3411
Onchocerca volvulus Glucosylceramidase homolog 0.0175 0.0363 0.6934
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0267 0.0567 0.505
Echinococcus multilocularis GPCR, family 2 0.0104 0.0204 0.0202
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.002 0.0018
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.002 0.0018
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0016 0.0014
Loa Loa (eye worm) hypothetical protein 0.0224 0.0472 0.4213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0016 0.0014
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0328 0.0703 0.6272
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0047 0.0045
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0363 0.6401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0031 0.0029
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0016 0.0014
Brugia malayi MH1 domain containing protein 0.0026 0.0031 0.026
Schistosoma mansoni nuclear hormone receptor 0.0021 0.002 0.0018
Schistosoma mansoni intermediate filament proteins 0.0028 0.0036 0.0034
Schistosoma mansoni hypothetical protein 0.0104 0.0204 0.0202
Brugia malayi MH2 domain containing protein 0.0026 0.0031 0.026
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.002 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0021 0.0378
Echinococcus multilocularis smad 0.0026 0.0031 0.0029
Schistosoma mansoni hypothetical protein 0.0104 0.0204 0.0202
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.0193 0.0191
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0007 0.0047
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0016 0.0809
Trypanosoma brucei polo-like protein kinase 0.0099 0.0193 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.002 0.0164
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0298 0.0636 0.0634
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0267 0.0567 0.5059
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0036 0.0325
Brugia malayi nuclear receptor NHR-88 0.0021 0.002 0.0164
Echinococcus granulosus lamin 0.0028 0.0036 0.0034
Onchocerca volvulus 0.0247 0.0522 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0016 0.0276
Echinococcus multilocularis Smad4 0.0026 0.0031 0.0029
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0048
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0181
Echinococcus multilocularis dnaJ subfamily B 0.0877 0.1925 0.1923
Schistosoma mansoni hypothetical protein 0.0397 0.0858 0.0856
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.002 0.0018
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0203 0.0424 0.0423
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.002 0.0018
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.0193 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.002 0.0181
Brugia malayi MH2 domain containing protein 0.0026 0.0031 0.026
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0099 0.0193 1
Schistosoma mansoni Replicative DNA helicase 0.045 0.0974 0.0973
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0025 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0325
Onchocerca volvulus 0.0028 0.0036 0.0661
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.002 0.0181
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0047 0.0045
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0567 1
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.002 0.0164
Schistosoma mansoni hypothetical protein 0.0224 0.0472 0.047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.002 0.0181
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0018
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0013 0.0002 0.0035
Loa Loa (eye worm) transcription factor SMAD2 0.038 0.0818 0.7303
Brugia malayi ecdysteroid receptor 0.0021 0.002 0.0164
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0013 0.0002 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0031 0.0553
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0025 0.0029 0.0027
Schistosoma mansoni hypothetical protein 0.0877 0.1925 0.1923
Schistosoma mansoni hypothetical protein 0.0104 0.0204 0.0202
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0363 0.6401
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.002 0.0164
Schistosoma mansoni smad 0.0026 0.0031 0.0029
Loa Loa (eye worm) hypothetical protein 0.0104 0.0204 0.1823
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.002 0.0164
Loa Loa (eye worm) nuclear factor I 0.0014 0.0005 0.0048

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 57.6 mM Displacement of [3H]prazosin from rat salivary gland alpha1A adrenoceptor ChEMBL. 19762239
IC50 (functional) > 100 mM Antagonist activity at rat alpha1A adrenoceptor assessed as inhibition of phenylephrine-induced contraction of caudal artery ChEMBL. 19762239

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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