TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 1069.24 | Formula: C56H80N2O18
H donors: 6 H acceptors: 6 LogP: 4.07 Rotable bonds: 9
Rule of 5 violations (Lipinski): 3
SMILES: CC(C1=C(O)C(=O)/C(=C\NCC2COCCOCCOCCOCCOCCO2)/c2c1cc(C)c(c2O)c1c(C)cc2c(c1O)/C(=C/NCC1COCCOCCOCCOCCOCCO1)/C(=O)C(=C2C(C)C)O)C
InChi: 1S/C56H80N2O18/c1-35(2)45-41-27-37(5)47(53(61)49(41)43(51(59)55(45)63)31-57-29-39-33-73-21-19-69-13-11-65-7-9-67-15-17-71-23-25-75-39)48-38(6)28-42-46(36(3)4)56(64)52(60)44(50(42)54(48)62)32-58-30-40-34-74-22-20-70-14-12-66-8-10-68-16-18-72-24-26-76-40/h27-28,31-32,35-36,39-40,57-58,61-64H,7-26,29-30,33-34H2,1-6H3/b43-31-,44-32-
InChiKey: DEWQJVJPIGTTDA-XOTMQJHLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0086	0.2414	0.4847
Plasmodium vivax	vivapain-3	0.0068	0.1628	0.364
Schistosoma mansoni	thyroid hormone receptor	0.0159	0.5645	0.9593
Entamoeba histolytica	cysteine proteinase, putative	0.0068	0.1628	0.2881
Brugia malayi	Inositol-1	0.0086	0.2414	0.2283
Plasmodium vivax	vivapain-2	0.0133	0.4473	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0068	0.1628	0.2137
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0091	0.2653	0.2527
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0077	0.2015	0.7593
Echinococcus granulosus	survival motor neuron protein 1	0.0237	0.9091	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0133	0.4473	1
Schistosoma mansoni	inositol monophosphatase	0.0086	0.2414	0.3595
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0042	0.0477	0.1066
Echinococcus multilocularis	inositol monophosphatase 1	0.0086	0.2414	0.2248
Entamoeba histolytica	cysteine protease, putative	0.0068	0.1628	0.2881
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0133	0.4473	1
Onchocerca volvulus		0.0133	0.4473	0.8524
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0133	0.4473	1
Brugia malayi	Cathepsin L-like precursor	0.0133	0.4473	0.4378
Echinococcus multilocularis	peptidase Clp (S14 family)	0.006	0.1259	0.0908
Brugia malayi	Cathepsin L-like precursor	0.0133	0.4473	0.4378
Trypanosoma cruzi	cruzipain precursor, putative	0.0044	0.0545	0.0171
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.1628	0.2881
Leishmania major	hypothetical protein, conserved	0.0055	0.1028	0.1379
Trypanosoma cruzi	cysteine peptidase, putative	0.0133	0.4473	1
Schistosoma mansoni	alpha-glucosidase	0.0164	0.5864	1
Loa Loa (eye worm)	cysteine protease	0.0133	0.4473	0.4196
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0098	0.2925	0.2843
Entamoeba histolytica	cysteine protease, putative	0.0068	0.1628	0.2881
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0086	0.2414	0.4847
Entamoeba histolytica	cysteine proteinase, putative	0.0133	0.4473	1
Echinococcus granulosus	cathepsin l1	0.0133	0.4473	0.4639
Schistosoma mansoni	hypothetical protein	0.0147	0.5122	0.8622
Loa Loa (eye worm)	hypothetical protein	0.0237	0.9091	0.9046
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0091	0.2653	0.5
Onchocerca volvulus		0.0089	0.2533	0.409
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0098	0.2925	0.2571
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0091	0.2653	0.5932
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0133	0.4473	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.4473	1
Leishmania major	cathepsin L-like protease	0.0133	0.4473	1
Onchocerca volvulus		0.0133	0.4473	0.8524
Onchocerca volvulus		0.0133	0.4473	0.8524
Schistosoma mansoni	peptidase Clp (S14 family)	0.0091	0.2653	0.404
Echinococcus granulosus	inositol monophosphatase 1	0.0086	0.2414	0.2248
Leishmania major	cathepsin L-like protease	0.0133	0.4473	1
Leishmania major	cathepsin L-like protease	0.0133	0.4473	1
Brugia malayi	Cathepsin L-like precursor	0.0133	0.4473	0.4378
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0133	0.4473	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.1628	0.2881
Plasmodium vivax	unspecified product	0.0068	0.1628	0.364
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0086	0.2414	0.4847
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0089	0.2533	0.5146
Echinococcus granulosus	lysosomal alpha glucosidase	0.0191	0.7038	0.7617
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0133	0.4473	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0133	0.4473	1
Entamoeba histolytica	cysteine protease, putative	0.0068	0.1628	0.2881
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0133	0.4473	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0086	0.2414	0.4847
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0545	0.0072
Entamoeba histolytica	cysteine proteinase, putative	0.0068	0.1628	0.2881
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0133	0.4473	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0055	0.1028	0.1379
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0133	0.4473	1
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0086	0.2414	0.4847
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0068	0.1628	0.2881
Onchocerca volvulus		0.0133	0.4473	0.8524
Echinococcus multilocularis	cysteine protease	0.0133	0.4473	0.4639
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.006	0.1259	0.4744
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0091	0.2653	0.2527
Echinococcus granulosus	cysteine protease	0.0068	0.1628	0.1336
Plasmodium falciparum	ataxin-2 like protein, putative	0.0055	0.1028	0.2298
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0133	0.4473	1
Leishmania major	cathepsin L-like protease	0.0133	0.4473	1
Brugia malayi	hypothetical protein	0.0237	0.9091	0.9076
Plasmodium vivax	vivapain-1	0.0068	0.1628	0.364
Schistosoma mansoni	cathepsin F (C01 family)	0.0089	0.2533	0.3817
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0159	0.5645	0.5999
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.4473	1
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0091	0.2653	0.5932
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0098	0.2925	0.2843
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0091	0.2653	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0068	0.1628	0.364
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0744	0.0585
Trypanosoma cruzi	cruzipain precursor, putative	0.0133	0.4473	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0133	0.4473	0.4639
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0133	0.4473	1
Onchocerca volvulus		0.0147	0.5118	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0044	0.0545	0.0171
Brugia malayi	follicle stimulating hormone receptor	0.0247	0.9555	0.9548
Onchocerca volvulus		0.011	0.3483	0.6261
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.1628	0.2881
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0098	0.2925	0.2843
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0545	0.0072
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0147	0.5122	0.5392
Echinococcus multilocularis	cathepsin L	0.0068	0.1628	0.1336
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0133	0.4473	0.4639
Entamoeba histolytica	cysteine proteinase, putative	0.0068	0.1628	0.2881
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0086	0.2414	0.4847
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2653	0.2285
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0133	0.4473	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0133	0.4473	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1028	0.0579
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0098	0.2925	0.4545
Brugia malayi	Papain family cysteine protease containing protein	0.0068	0.1628	0.1484
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0545	0.0072
Echinococcus granulosus	cathepsin l1	0.0089	0.2533	0.2387
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.4473	1
Schistosoma mansoni	inositol monophosphatase	0.0086	0.2414	0.3595
Entamoeba histolytica	cysteine protease, putative	0.0068	0.1628	0.2881
Schistosoma mansoni	cathepsin s	0.0044	0.0545	0.0127
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.4473	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0133	0.4473	1
Onchocerca volvulus		0.0133	0.4473	0.8524
Loa Loa (eye worm)	fibroinase	0.0133	0.4473	0.4196
Trypanosoma cruzi	cysteine proteinase, putative	0.0068	0.1628	0.2881
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0091	0.2653	0.5
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0042	0.0477	0.0313
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0091	0.2653	0.5932
Brugia malayi	Probable ClpP-like protease	0.0091	0.2653	0.2527
Brugia malayi	Papain family cysteine protease containing protein	0.0068	0.1628	0.1484
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0133	0.4473	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0044	0.0545	0.0072
Entamoeba histolytica	cysteine protease, putative	0.0068	0.1628	0.2881
Trypanosoma cruzi	cysteine peptidase, putative	0.0133	0.4473	1
Leishmania major	cathepsin L-like protease	0.0133	0.4473	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0133	0.4473	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0055	0.1028	0.1379
Entamoeba histolytica	cysteine proteinase 2	0.0068	0.1628	0.2881
Entamoeba histolytica	cysteine proteinase, putative	0.0133	0.4473	1
Brugia malayi	Cathepsin L-like precursor	0.0133	0.4473	0.4378
Entamoeba histolytica	cysteine proteinase, putative	0.0089	0.2533	0.5146
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0091	0.2653	1
Schistosoma mansoni	alpha-glucosidase	0.0164	0.5864	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.1628	0.2881
Brugia malayi	Cathepsin L-like precursor	0.0133	0.4473	0.4378
Leishmania major	cathepsin L-like protease	0.0133	0.4473	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0098	0.2925	0.4545
Brugia malayi	hypothetical protein	0.0147	0.5118	0.5034
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0191	0.7038	0.7617
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0133	0.4473	1
Echinococcus granulosus	cathepsin L	0.0068	0.1628	0.1336
Entamoeba histolytica	cysteine protease, putative	0.0068	0.1628	0.2881
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0133	0.4473	1
Onchocerca volvulus	Cathepsin L homolog	0.0133	0.4473	0.8524
Schistosoma mansoni	cathepsin F (C01 family)	0.0133	0.4473	0.7417
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0133	0.4473	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0044	0.0545	0.0382
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0133	0.4473	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0086	0.2414	0.4847
Entamoeba histolytica	cysteine proteinase 1, putative	0.0068	0.1628	0.2881
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0133	0.4473	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0098	0.2925	0.4545
Trypanosoma cruzi	cysteine protease, putative	0.0068	0.1628	0.2881
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0744	0.0497
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0133	0.4473	0.4639
Toxoplasma gondii	LsmAD domain-containing protein	0.0055	0.1028	0.2298
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0089	0.2533	0.2404
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0091	0.2653	1
Schistosoma mansoni	thyroid hormone receptor	0.0159	0.5645	0.9593
Entamoeba histolytica	cysteine protease, putative	0.0068	0.1628	0.2881
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.4473	1
Brugia malayi	Cathepsin L-like precursor	0.0089	0.2533	0.2404
Plasmodium vivax	unspecified product	0.0044	0.0545	0.1219
Entamoeba histolytica	cysteine protease, putative	0.0068	0.1628	0.2881
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0068	0.1628	0.2137
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0133	0.4473	1
Brugia malayi	Cathepsin L-like precursor	0.0089	0.2533	0.2404
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0133	0.4473	1
Onchocerca volvulus	Cathepsin F homolog	0.0133	0.4473	0.8524
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.4473	1
Trichomonas vaginalis	inositol monophosphatase, putative	0.0086	0.2414	0.4847
Entamoeba histolytica	cysteine protease, putative	0.0068	0.1628	0.2881
Loa Loa (eye worm)	hypothetical protein	0.0147	0.5118	0.4874
Brugia malayi	cathepsin F-like cysteine proteinase	0.0044	0.0545	0.0382
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0191	0.7038	0.689
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0147	0.5122	0.5392
Onchocerca volvulus		0.0133	0.4473	0.8524
Loa Loa (eye worm)	inositol-1	0.0086	0.2414	0.2034
Loa Loa (eye worm)	hypothetical protein	0.0089	0.2533	0.2159
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0133	0.4473	0.4639
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.4473	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0068	0.1628	0.2881
Entamoeba histolytica	cysteine proteinase, putative	0.0068	0.1628	0.2881
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0247	0.9555	0.9533
Onchocerca volvulus	Cathepsin L homolog	0.0133	0.4473	0.8524
Trypanosoma cruzi	PAB1-binding protein , putative	0.0055	0.1028	0.1379
Brugia malayi	hypothetical protein	0.0055	0.1028	0.0873
Schistosoma mansoni	cathepsin F (C01 family)	0.0133	0.4473	0.7417
Leishmania major	cathepsin L-like protease	0.0133	0.4473	1
Loa Loa (eye worm)	hypothetical protein	0.0133	0.4473	0.4196
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0091	0.2653	1
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0091	0.2653	0.5932
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0133	0.4473	0.4639
Entamoeba histolytica	cysteine protease, putative	0.0068	0.1628	0.2881
Onchocerca volvulus		0.0133	0.4473	0.8524
Echinococcus multilocularis	cathepsin L cysteine protease	0.0133	0.4473	0.4639
Entamoeba histolytica	cysteine protease, putative	0.0068	0.1628	0.2881
Brugia malayi	Papain family cysteine protease containing protein	0.0133	0.4473	0.4378
Toxoplasma gondii	cathepsin CPL	0.0133	0.4473	1
Brugia malayi	cathepsin L-like precursor	0.0089	0.2533	0.2404
Trypanosoma cruzi	cysteine peptidase, putative	0.0133	0.4473	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0055	0.1028	0.2298
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0133	0.4473	0.4196
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0089	0.2533	0.5146
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0091	0.2653	1
Brugia malayi	Cathepsin L-like precursor	0.0133	0.4473	0.4378
Entamoeba histolytica	cysteine protease, putative	0.0068	0.1628	0.2881
Entamoeba histolytica	cysteine protease, putative	0.0068	0.1628	0.2881
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0098	0.2925	0.2804
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0077	0.2015	1
Leishmania major	cysteine peptidase A (CPA)	0.0133	0.4473	1
Loa Loa (eye worm)	ctsf protein	0.0133	0.4473	0.4196
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0086	0.2414	0.5396
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0133	0.4473	1
Echinococcus multilocularis	cysteine protease	0.0133	0.4473	0.4639
Trypanosoma cruzi	cysteine proteinase, putative	0.0068	0.1628	0.2881
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0133	0.4473	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.2533	0.2159
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0098	0.2925	0.2843
Loa Loa (eye worm)	hypothetical protein	0.0089	0.2533	0.2159
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0191	0.7038	0.7617
Leishmania major	cathepsin L-like protease	0.0133	0.4473	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0068	0.1628	0.2137
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0089	0.2533	0.5146
Echinococcus granulosus	cathepsin L cysteine protease	0.0068	0.1628	0.1336
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0133	0.4473	1
Schistosoma mansoni	hypothetical protein	0.0048	0.0744	0.0497
Entamoeba histolytica	cysteine protease, putative	0.0133	0.4473	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.4473	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0055	0.1028	0.2298
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0133	0.4473	1
Plasmodium vivax	vivapain-2	0.0133	0.4473	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0133	0.4473	0.4196
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.4473	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.4473	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.4473	1
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0545	0.0382
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0133	0.4473	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0237	0.9091	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0191	0.7038	0.6987
Echinococcus granulosus	peptidase Clp S14 family	0.006	0.1259	0.0908

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL570569

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1070501