Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0063 | 0.084 | 0.1418 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0124 | 0.3184 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0124 | 0.3184 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.084 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.084 | 1 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0195 | 0.5924 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0124 | 0.3184 | 1 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.005 | 0.032 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0584 | 0.1833 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0195 | 0.5924 | 1 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.005 | 0.032 | 0.054 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.084 | 1 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.005 | 0.032 | 0.054 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.084 | 0.084 |
Schistosoma mansoni | sex comb on midleg homolog | 0.005 | 0.032 | 0.032 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0063 | 0.084 | 0.0983 |
Onchocerca volvulus | 0.005 | 0.032 | 1 | |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0063 | 0.084 | 0.1418 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.084 | 0.084 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0264 | 0.8547 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0063 | 0.084 | 1 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.005 | 0.032 | 0.054 |
Brugia malayi | mbt repeat family protein | 0.005 | 0.032 | 0.1004 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0056 | 0.0584 | 0.0985 |
Loa Loa (eye worm) | MBCTL1 | 0.0056 | 0.0584 | 0.1833 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0056 | 0.0584 | 0.0985 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0056 | 0.0584 | 0.1833 |
Schistosoma mansoni | sex comb on midleg homolog | 0.005 | 0.032 | 0.032 |
Brugia malayi | mbt repeat family protein | 0.005 | 0.032 | 0.1004 |
Loa Loa (eye worm) | mbt repeat family protein | 0.005 | 0.032 | 0.1004 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0056 | 0.0584 | 0.0985 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0056 | 0.0584 | 0.0584 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.005 | 0.032 | 0.032 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0056 | 0.0584 | 0.0985 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0063 | 0.084 | 1 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.005 | 0.032 | 0.054 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.032 | 0.1004 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.