TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 349.211 | Formula: C17H14Cl2N2O2
H donors: 2 H acceptors: 2 LogP: 3.8 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1c1c[nH]c(n1)C(c1cc(Cl)cc(c1)Cl)O
InChi: 1S/C17H14Cl2N2O2/c1-23-15-5-3-2-4-13(15)14-9-20-17(21-14)16(22)10-6-11(18)8-12(19)7-10/h2-9,16,22H,1H3,(H,20,21)
InChiKey: HFUGTBVUFJILEP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Trypanosoma brucei	methionyl-tRNA synthetase, putative	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania mexicana	methionyl-tRNA synthetase, putative	Get druggable targets OG5_127468	All targets in OG5_127468
Echinococcus granulosus	methionine tRNA synthetase	Get druggable targets OG5_127468	All targets in OG5_127468
Schistosoma japonicum	ko:K01874 methionyl-tRNA synthetase [EC6.1.1.10], putative	Get druggable targets OG5_127468	All targets in OG5_127468
Theileria parva	methionyl-tRNA synthetase, putative	Get druggable targets OG5_127468	All targets in OG5_127468
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Cryptosporidium parvum	methionyl-tRNA synthetase of possible bacterial origin	Get druggable targets OG5_127468	All targets in OG5_127468
Mycobacterium tuberculosis	Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase)	Get druggable targets OG5_127468	All targets in OG5_127468
Plasmodium knowlesi	methionine--tRNA ligase, putative	Get druggable targets OG5_127468	All targets in OG5_127468
Leishmania braziliensis	methionyl-tRNA synthetase, putative	Get druggable targets OG5_127468	All targets in OG5_127468
Plasmodium vivax	methionine--tRNA ligase, putative	Get druggable targets OG5_127468	All targets in OG5_127468
Neospora caninum	Methionine--tRNA ligase (EC 6.1.1.10), related	Get druggable targets OG5_127468	All targets in OG5_127468
Plasmodium berghei	methionine--tRNA ligase, putative	Get druggable targets OG5_127468	All targets in OG5_127468
Candida albicans	mitochondrial tRNA methionyl-tRNA synthetase similar to S. cerevisiae MSM1 (YGR171C) mitochondrial methionyl-tRNA synthetase	Get druggable targets OG5_127468	All targets in OG5_127468
Giardia lamblia	Methionyl-tRNA synthetase	Get druggable targets OG5_127468	All targets in OG5_127468
Cryptosporidium hominis	methionine -- tRNA ligase	Get druggable targets OG5_127468	All targets in OG5_127468
Toxoplasma gondii	methionyl-tRNA synthetase	Get druggable targets OG5_127468	All targets in OG5_127468
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Leishmania major	methionyl-tRNA synthetase, putative	Get druggable targets OG5_127468	All targets in OG5_127468
Leishmania infantum	methionyl-tRNA synthetase, putative	Get druggable targets OG5_127468	All targets in OG5_127468
Trichomonas vaginalis	methionine-tRNA synthetase, putative	Get druggable targets OG5_127468	All targets in OG5_127468
Loa Loa (eye worm)	tyrosyl-tRNA synthetase	Get druggable targets OG5_127468	All targets in OG5_127468
Wolbachia endosymbiont of Brugia malayi	methionyl-tRNA synthetase	Get druggable targets OG5_127468	All targets in OG5_127468
Mycobacterium ulcerans	methionyl-tRNA synthetase	Get druggable targets OG5_127468	All targets in OG5_127468
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Echinococcus multilocularis	methionine tRNA synthetase	Get druggable targets OG5_127468	All targets in OG5_127468
Brugia malayi	methionyl-tRNA synthetase	Get druggable targets OG5_127468	All targets in OG5_127468
Trypanosoma brucei gambiense	methionyl-tRNA synthetase, putative	Get druggable targets OG5_127468	All targets in OG5_127468
Babesia bovis	methionyl-tRNA synthetase, putative	Get druggable targets OG5_127468	All targets in OG5_127468
Trypanosoma congolense	methionyl-tRNA synthetase, putative	Get druggable targets OG5_127468	All targets in OG5_127468
Plasmodium falciparum	methionine--tRNA ligase	Get druggable targets OG5_127468	All targets in OG5_127468
Mycobacterium leprae	Probable methionyl-tRNA synthase MetS	Get druggable targets OG5_127468	All targets in OG5_127468
Onchocerca volvulus		Get druggable targets OG5_127468	All targets in OG5_127468
Leishmania donovani	methionyl-tRNA synthetase, putative	Get druggable targets OG5_127468	All targets in OG5_127468
Theileria parva	methionyl-tRNA synthetase, putative	Get druggable targets OG5_127468	All targets in OG5_127468
Loa Loa (eye worm)	methionyl-tRNA synthetase	Get druggable targets OG5_127468	All targets in OG5_127468
Trypanosoma brucei	methionyl-tRNA synthetase, putative	Get druggable targets OG5_127468	All targets in OG5_127468
Candida albicans	mitochondrial tRNA methionyl-tRNA synthetase similar to S. cerevisiae MSM1 (YGR171C) mitochondrial methionyl-tRNA synthetase	Get druggable targets OG5_127468	All targets in OG5_127468
Trypanosoma cruzi	methionyl-tRNA synthetase, putative	Get druggable targets OG5_127468	All targets in OG5_127468
Schistosoma mansoni	methionine-tRNA synthetase	Get druggable targets OG5_127468	All targets in OG5_127468
Plasmodium yoelii	methionyl-tRNA synthetase	Get druggable targets OG5_127468	All targets in OG5_127468

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	protein ZK524.3	0.0025	0.0596	0.1404
Mycobacterium leprae	Probable methionyl-tRNA synthase MetS	0.0066	0.1855	1
Trypanosoma brucei	unspecified product	0.0019	0.0404	0.0404
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0336	0.1122
Schistosoma mansoni	Smad4	0.001	0.0119	0.0445
Echinococcus multilocularis	smad	0.001	0.0119	0.0305
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0336	0.1187
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.089	0.1718
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.1791	0.1791
Onchocerca volvulus		0.0017	0.0336	0.0679
Onchocerca volvulus		0.0035	0.089	0.2876
Brugia malayi	MH1 domain containing protein	0.001	0.0119	0.0282
Echinococcus granulosus	cathepsin l1	0.0011	0.0165	0.0476
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.089	0.0776
Trypanosoma brucei	methionyl-tRNA synthetase, putative	0.0066	0.1855	0.1855
Onchocerca volvulus		0.0017	0.0336	0.0679
Plasmodium vivax	unspecified product	0.0009	0.0085	0.0457
Echinococcus granulosus	cysteine protease	0.0009	0.0085	0.0174
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0011	0.0165	0.0388
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1332	0.3141
Brugia malayi	ImpB/MucB/SamB family protein	0.0044	0.1178	0.2777
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0085	0.0246
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0297	0.0701
Trichomonas vaginalis	esterase, putative	0.0035	0.089	0.3264
Onchocerca volvulus		0.0017	0.0336	0.0679
Echinococcus granulosus	smad	0.001	0.0119	0.0305
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.0085	0.0316
Trypanosoma brucei	unspecified product	0.0013	0.0222	0.0222
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0093	0.0204
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.0336	0.0679
Echinococcus multilocularis	mothers against decapentaplegic 5	0.001	0.0119	0.0305
Mycobacterium tuberculosis	Conserved protein	0.0035	0.089	0.0776
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0706	0.1665
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0404	0.1504
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.089	0.089
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.089	0.3313
Leishmania major	cathepsin L-like protease	0.0017	0.0336	0.0336
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1791	0.1791
Trypanosoma cruzi	cysteine peptidase, putative	0.0017	0.0336	0.0336
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0404	0.0404
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0157	0.4637	0.4637
Trypanosoma cruzi	polo-like protein kinase, putative	0.0094	0.2687	0.2687
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0404	0.0404
Trypanosoma cruzi	methionyl-tRNA synthetase, putative	0.0066	0.1855	0.1855
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0094	0.2687	1
Entamoeba histolytica	methionyl-tRNA synthetase, putative	0.0025	0.0596	0.1963
Toxoplasma gondii	cathepsin CPL	0.0017	0.0336	0.181
Entamoeba histolytica	cysteine proteinase, putative	0.0011	0.0165	0.0307
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0009	0.0085	0.0457
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1791	0.1791
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0336	0.1187
Mycobacterium ulcerans	hypothetical protein	0.0035	0.089	0.1718
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0031	0.0774	0.4171
Toxoplasma gondii	methionyl-tRNA synthetase	0.0066	0.1855	1
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0094	0.2687	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0336	0.1187
Plasmodium vivax	hypothetical protein, conserved	0.0025	0.0596	0.3211
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0336	0.1187
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.089	0.3264
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.0085	0.0316
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1791	0.1791
Trypanosoma cruzi	major cysteine proteinase, putative	0.0051	0.1369	0.1369
Giardia lamblia	Leucyl-tRNA synthetase	0.0025	0.0596	0.2217
Leishmania major	cathepsin L-like protease	0.0017	0.0336	0.0336
Echinococcus granulosus	GPCR family 2	0.0016	0.0297	0.0976
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0404	0.0404
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.2687	1
Trypanosoma cruzi	cysteine protease, putative	0.0009	0.0085	0.0085
Brugia malayi	beta-lactamase family protein	0.0035	0.089	0.2099
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0017	0.0336	0.181
Echinococcus multilocularis	Smad4	0.001	0.0119	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0165	0.0388
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0009	0.0085	0.0085
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0706	0.1665
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0336	0.0792
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1791	0.1791
Loa Loa (eye worm)	hypothetical protein	0.0044	0.1178	0.2777
Leishmania major	cathepsin L-like protease	0.0017	0.0336	0.0336
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0093	0.0219
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0336	0.1187
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0093	0.0204
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0336	0.1187
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0336	0.1187
Echinococcus multilocularis	methionyl tRNA synthetase, cytoplasmic	0.0025	0.0596	0.2103
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0404	0.0404
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0404	0.0404
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0089	0.0211
Schistosoma mansoni	methionine-tRNA synthetase	0.0066	0.1855	0.6904
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0336	0.1187
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.089	0.3264
Mycobacterium tuberculosis	Conserved protein	0.0035	0.089	0.0776
Schistosoma mansoni	smad1 5 8 and	0.001	0.0119	0.0445
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0336	0.0792
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.089	0.3264
Schistosoma mansoni	hypothetical protein	0.0034	0.0853	0.3175
Echinococcus multilocularis	cysteine protease	0.0017	0.0336	0.1122
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.089	0.0776
Echinococcus granulosus	dna polymerase eta	0.0044	0.1178	0.4302
Plasmodium vivax	vivapain-1	0.0009	0.0085	0.0457
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0017	0.0336	0.1122
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0297	0.0701
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0047	0.125	0.125
Loa Loa (eye worm)	hypothetical protein	0.0035	0.089	0.2099
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1791	0.1791
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0404	0.0953
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1791	0.1791
Mycobacterium tuberculosis	Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase)	0.0066	0.1855	0.2317
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0336	0.0792
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.1501	0.8089
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0039	0.0144
Brugia malayi	Papain family cysteine protease containing protein	0.0009	0.0085	0.02
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.089	0.3313
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0047	0.125	0.125
Onchocerca volvulus		0.0017	0.0336	0.0679
Leishmania major	cathepsin L-like protease	0.0017	0.0336	0.0336
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0336	0.0965
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0336	0.1187
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.2687	1
Trichomonas vaginalis	methionine-tRNA synthetase, putative	0.0066	0.1855	0.6882
Schistosoma mansoni	leucyl-tRNA synthetase	0.0025	0.0596	0.2217
Chlamydia trachomatis	methionine--tRNA ligase	0.0025	0.0596	0.5
Echinococcus granulosus	mothers against decapentaplegic 5	0.001	0.0119	0.0305
Loa Loa (eye worm)	beta-lactamase	0.0035	0.089	0.2099
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.4242	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0085	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0165	0.0388
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0404	0.0404
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0297	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0165	0.0388
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0404	0.0404
Schistosoma mansoni	cpg binding protein	0.0031	0.0757	0.2817
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0404	0.138
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0336	0.0965
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.0085	0.0316
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.2687	1
Brugia malayi	Papain family cysteine protease containing protein	0.0009	0.0085	0.02
Onchocerca volvulus		0.0017	0.0336	0.0679
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0336	0.1187
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0336	0.1187
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0596	0.1404
Leishmania major	cathepsin L-like protease	0.0017	0.0336	0.0336
Brugia malayi	Smad1	0.001	0.0119	0.0282
Brugia malayi	cathepsin L-like precursor	0.0011	0.0165	0.0388
Loa Loa (eye worm)	ctsf protein	0.0017	0.0336	0.0792
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.089	0.3264
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.2687	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0297	0.0701
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.089	0.3215
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.2687	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0404	0.0404
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.089	0.0776
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.1332	0.3141
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.001	0.0119	0.0445
Wolbachia endosymbiont of Brugia malayi	methionyl-tRNA synthetase	0.0066	0.1855	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0222	0.0222
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0222	0.0222
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1791	0.1791
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0336	0.0792
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0175	0.5181	0.7627
Onchocerca volvulus		0.0041	0.1078	0.3619
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0404	0.0404
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0404	0.0404
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0404	0.0953
Echinococcus granulosus	cpg binding protein	0.0031	0.0757	0.2712
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1791	0.1791
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0057	0.1563	0.1563
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.2687	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0017	0.0336	0.181
Trypanosoma cruzi	cysteine proteinase, putative	0.0009	0.0085	0.0085
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.1238	0.4569
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0165	0.0545
Onchocerca volvulus		0.0035	0.089	0.2876
Loa Loa (eye worm)	methionyl-tRNA synthetase	0.0066	0.1855	0.4374
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.089	0.0776
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.089	0.089
Giardia lamblia	Kinase, PLK	0.0094	0.2687	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0404	0.0404
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0297	0.0976
Onchocerca volvulus	Cathepsin F homolog	0.0017	0.0336	0.0679
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0336	0.1187
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0336	0.1187
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0009	0.0085	0.0085
Mycobacterium ulcerans	beta-lactamase	0.0035	0.089	0.1718
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0297	0.0976
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.089	0.3264
Schistosoma mansoni	cathepsin F (C01 family)	0.0011	0.0165	0.0613
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0404	0.0404
Schistosoma mansoni	hypothetical protein	0.0016	0.0297	0.1106
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0336	0.1122
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0853	0.2011
Schistosoma mansoni	smad1 5 8 and	0.001	0.0119	0.0445
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0336	0.1187
Mycobacterium ulcerans	lipase LipD	0.0035	0.089	0.1718
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0223	0.6668	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0404	0.0404
Onchocerca volvulus		0.0017	0.0336	0.0679
Brugia malayi	MH1 domain containing protein	0.001	0.0119	0.0282
Leishmania major	cysteine peptidase A (CPA)	0.0017	0.0336	0.0336
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0094	0.2687	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0017	0.0336	0.0792
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0336	0.1187
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0165	0.0545
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0094	0.2687	0.6335
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0404	0.138
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0336	0.1187
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0404	0.078
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.089	0.089
Mycobacterium ulcerans	methionyl-tRNA synthetase	0.0066	0.1855	0.3581
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0404	0.138
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0336	0.1187
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.089	0.0776
Leishmania major	leucyl-tRNA synthetase, putative	0.0025	0.0596	0.0596
Trypanosoma brucei	unspecified product	0.0013	0.0222	0.0222
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.089	0.2099
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.1332	0.3141
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0297	0.0976
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.1702	0.6334
Mycobacterium tuberculosis	Conserved protein	0.0035	0.089	0.0776
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0336	0.0792
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0017	0.0336	0.181
Brugia malayi	methionyl-tRNA synthetase	0.0066	0.1855	0.4374
Leishmania major	methionyl-tRNA synthetase, putative	0.0066	0.1855	0.1855
Brugia malayi	beta-lactamase family protein	0.0035	0.089	0.2099
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0336	0.1187
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0009	0.0085	0.0085
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.1238	0.4569
Loa Loa (eye worm)	MH2 domain-containing protein	0.001	0.0119	0.0282
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0336	0.1187
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1791	0.1791
Echinococcus multilocularis	dna polymerase eta	0.0044	0.1178	0.4302
Trypanosoma cruzi	DNA polymerase eta, putative	0.0044	0.1178	0.1178
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0336	0.1187
Brugia malayi	beta-lactamase	0.0035	0.089	0.2099
Onchocerca volvulus		0.0035	0.089	0.2876
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.089	0.0776
Plasmodium vivax	vivapain-3	0.0009	0.0085	0.0457
Echinococcus multilocularis	methionine tRNA synthetase	0.0066	0.1855	0.6859
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0222	0.0222
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0404	0.0404
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.0404	0.1227
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0404	0.078
Schistosoma mansoni	hypothetical protein	0.0016	0.0297	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0596	0.1404
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.089	0.3215
Schistosoma mansoni	smad	0.001	0.0119	0.0445
Mycobacterium ulcerans	hypothetical protein	0.0175	0.5181	1
Leishmania major	hypothetical protein, conserved	0.0035	0.089	0.089
Mycobacterium ulcerans	leucyl-tRNA synthetase	0.0025	0.0596	0.115
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0404	0.1443
Toxoplasma gondii	hypothetical protein	0.0054	0.146	0.7871
Plasmodium vivax	methionine--tRNA ligase, putative	0.0025	0.0596	0.3211
Brugia malayi	serine/threonine-protein kinase plk-2	0.0094	0.2687	0.6335
Chlamydia trachomatis	leucine--tRNA ligase	0.0025	0.0596	0.5
Loa Loa (eye worm)	cysteine protease	0.0017	0.0336	0.0792
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0094	0.2687	1
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0094	0.2687	0.2687
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0596	0.1404
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0404	0.1504
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0047	0.125	0.125
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0404	0.0404
Brugia malayi	Cathepsin L-like precursor	0.0011	0.0165	0.0388
Echinococcus granulosus	TGF beta signal transducer SmadC	0.001	0.0119	0.0305
Trypanosoma cruzi	polo-like protein kinase, putative	0.0094	0.2687	0.2687
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.1791	0.1791
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0404	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0336	0.0792
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.1332	0.3141
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0157	0.4637	0.4637
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0404	0.0404
Echinococcus multilocularis	cpg binding protein	0.0031	0.0757	0.2712
Brugia malayi	MH2 domain containing protein	0.001	0.0119	0.0282
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.089	0.2099
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.089	0.1718
Loa Loa (eye worm)	hypothetical protein	0.0035	0.089	0.2099
Schistosoma mansoni	hypothetical protein	0.0016	0.0297	0.1106
Onchocerca volvulus		0.0029	0.0706	0.2147
Treponema pallidum	leucyl-tRNA synthetase	0.0025	0.0596	0.5
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0336	0.125
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0404	0.138
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0047	0.125	0.125
Leishmania major	DNA polymerase eta, putative	0.0031	0.0774	0.0774
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0336	0.1187
Echinococcus granulosus	methionyl tRNA synthetase cytoplasmic	0.0025	0.0596	0.2103
Echinococcus granulosus	cathepsin l1	0.0017	0.0336	0.1122
Schistosoma mansoni	methionine-tRNA synthetase	0.0025	0.0596	0.2217
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.001	0.0119	0.0305
Leishmania major	cathepsin L-like protease	0.0064	0.1791	0.1791
Plasmodium vivax	methionine--tRNA ligase, putative	0.0066	0.1855	1
Echinococcus multilocularis	cysteine protease	0.0017	0.0336	0.1122
Schistosoma mansoni	cpg binding protein	0.0031	0.0757	0.2817
Giardia lamblia	Methionyl-tRNA synthetase	0.0066	0.1855	0.6904
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0336	0.0792
Loa Loa (eye worm)	hypothetical protein	0.0035	0.089	0.2099
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0297	0.0701
Schistosoma mansoni	smad1 5 8 and	0.001	0.0119	0.0445
Leishmania major	DNA polymerase eta, putative	0.0044	0.1178	0.1178
Toxoplasma gondii	ABC1 family protein	0.0035	0.089	0.4798
Brugia malayi	methionyl-tRNA synthetase	0.0025	0.0596	0.1404
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0404	0.0404
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0336	0.1187
Onchocerca volvulus		0.0017	0.0336	0.0679
Schistosoma mansoni	DNA polymerase eta	0.0044	0.1178	0.4384
Echinococcus granulosus	methionine tRNA synthetase	0.0066	0.1855	0.6859
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0059	0.162	0.162
Loa Loa (eye worm)	hypothetical protein	0.0035	0.089	0.2099
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0336	0.1187
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.0336	0.0679
Brugia malayi	Cathepsin L-like precursor	0.0011	0.0165	0.0388
Loa Loa (eye worm)	tyrosyl-tRNA synthetase	0.0041	0.1078	0.2541
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0336	0.0792
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0157	0.4637	0.4637
Loa Loa (eye worm)	hypothetical protein	0.0035	0.089	0.2099
Plasmodium falciparum	methionine--tRNA ligase	0.0066	0.1855	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0009	0.0085	0.0085
Brugia malayi	MH2 domain containing protein	0.001	0.0119	0.0282
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.1791	0.1791
Loa Loa (eye worm)	MH1 domain-containing protein	0.001	0.0119	0.0282
Schistosoma mansoni	hypothetical protein	0.0016	0.0297	0.1106
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0336	0.125
Plasmodium falciparum	methionine--tRNA ligase, putative	0.0025	0.0596	0.3211
Echinococcus granulosus	cathepsin L	0.0009	0.0085	0.0174
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0336	0.1187
Schistosoma mansoni	serine/threonine protein kinase	0.0094	0.2687	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0009	0.0085	0.0085
Echinococcus multilocularis	cathepsin L	0.0009	0.0085	0.0174
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0017	0.0336	0.0792
Leishmania major	cathepsin L-like protease	0.0064	0.1791	0.1791
Loa Loa (eye worm)	fibroinase	0.0017	0.0336	0.0792
Echinococcus granulosus	cathepsin L cysteine protease	0.0009	0.0085	0.0174
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0336	0.0965
Leishmania major	cathepsin L-like protease	0.0064	0.1791	0.1791
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.089	0.0776
Loa Loa (eye worm)	Smad1	0.001	0.0119	0.0282
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0336	0.1122
Trypanosoma brucei	DNA polymerase eta, putative	0.0044	0.1178	0.1178
Toxoplasma gondii	tRNA ligases class I (M) protein	0.0025	0.0596	0.3211
Plasmodium vivax	vivapain-2	0.0017	0.0336	0.181
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1791	0.1791
Schistosoma mansoni	kinase	0.0048	0.1276	0.4749
Brugia malayi	MH2 domain containing protein	0.0144	0.4242	1
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0404	0.1504
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1791	0.1791
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0336	0.1187
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.2687	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.4242	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0404	0.0404
Echinococcus granulosus	Smad4	0.001	0.0119	0.0305
Treponema pallidum	methionyl-tRNA synthetase	0.0025	0.0596	0.5
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0297	0.0976
Trypanosoma cruzi	cruzipain precursor, putative	0.0064	0.1791	0.1791
Schistosoma mansoni	cpg binding protein	0.0029	0.0706	0.2628
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0336	0.1122
Trypanosoma cruzi	DNA polymerase eta, putative	0.0031	0.0774	0.0774
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0853	0.2011
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.089	0.4798
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0404	0.1443
Trypanosoma brucei	polo-like protein kinase	0.0094	0.2687	0.2687
Plasmodium vivax	vivapain-2	0.0017	0.0336	0.181
Echinococcus multilocularis	leucyl tRNA synthetase	0.0025	0.0596	0.2103
Loa Loa (eye worm)	hypothetical protein	0.0035	0.089	0.2099
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0017	0.0336	0.1122

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	2.383 uM	PubChem BioAssay. Luminescence-based biochemical high throughput dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS). (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (functional)	3.26 uM	PubChem BioAssay. Counterscreen Fluorescent Polarization-based biochemical high throughput orthogonal dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1866383

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1071006