Detailed information for compound 1071626

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 459.325 | Formula: C22H20Cl2N4O3
  • H donors: 0 H acceptors: 3 LogP: 3.33 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C(=O)CC(C(=O)c1ccc(cc1)Cl)C1C(=N)N(C)C(=O)N(C1=N)C
  • InChi: 1S/C22H20Cl2N4O3/c1-27-20(25)18(21(26)28(2)22(27)31)16(19(30)13-5-9-15(24)10-6-13)11-17(29)12-3-7-14(23)8-4-12/h3-10,16,18,25-26H,11H2,1-2H3
  • InChiKey: PMYTVTUSZFPFBE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0124 0.0164
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0071 0.0308 0.3291
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0124 0.0164
Plasmodium vivax glutathione reductase, putative 0.0085 0.0394 0.438
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0065 0.0267 0.2772
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0124 0.0122
Echinococcus multilocularis beta LACTamase domain containing family member 0.0156 0.0837 0.0835
Echinococcus granulosus snurportin 1 0.0938 0.5691 0.7635
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0071 0.0093
Toxoplasma gondii thioredoxin reductase 0.0085 0.0394 0.451
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0323 0.0431
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0082 0.0154
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.0219 0.2167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0124 0.0214
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0008 0.0008
Onchocerca volvulus 0.0042 0.0124 0.1017
Brugia malayi nuclear hormone receptor 0.0042 0.0124 0.043
Brugia malayi MH2 domain containing protein 0.0487 0.2887 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0194 0.1071 0.1697
Trypanosoma brucei hypothetical protein, conserved 0.0156 0.0837 0.3586
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0156 0.0837 0.2899
Toxoplasma gondii ABC1 family protein 0.0156 0.0837 1
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0183 0.1897
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0194 0.1071 0.1697
Brugia malayi MH2 domain containing protein 0.0033 0.0071 0.0247
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0071 0.0122
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.022
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0183 0.0611
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0049 0.0232
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.0843 0.0841
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0156 0.0837 0.1309
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0071 0.0308 0.3291
Loa Loa (eye worm) latrophilin receptor protein 2 0.0095 0.0454 0.0794
Loa Loa (eye worm) hypothetical protein 0.0156 0.0837 0.1467
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0124 0.0164
Schistosoma mansoni hypothetical protein 0.0118 0.0598 0.08
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0124 0.0214
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0127 0.0441
Brugia malayi beta-lactamase 0.0156 0.0837 0.2899
Schistosoma mansoni smad1 5 8 and 0.0033 0.0071 0.0093
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0095 0.0454 0.1571
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0219 0.0777
Schistosoma mansoni alpha-glucosidase 0.0135 0.0707 0.0946
Echinococcus multilocularis lamin dm0 0.0031 0.006 0.0058
Trypanosoma brucei importin beta-1 subunit, putative 0.0088 0.0411 0.1649
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0082 0.008
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0219 0.4712
Mycobacterium ulcerans beta-lactamase 0.0156 0.0837 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0124 0.043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0479 0.2842 0.3811
Echinococcus granulosus lamin 0.0031 0.006 0.0078
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0124 0.0164
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0071 0.0093
Trichomonas vaginalis D-aminoacylase, putative 0.0156 0.0837 1
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0026 0.003 0.0037
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0194 0.1071 0.1697
Echinococcus multilocularis musashi 0.0031 0.006 0.0058
Mycobacterium tuberculosis Probable lipase LipE 0.0156 0.0837 0.1309
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0065 0.0267 0.0265
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0219 0.0217
Plasmodium falciparum glutathione reductase 0.0085 0.0394 0.9522
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0156 0.0837 0.1467
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0183 0.0611
Echinococcus multilocularis geminin 0.1222 0.7453 0.7452
Mycobacterium tuberculosis Conserved protein 0.0156 0.0837 0.1309
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0219 0.2167
Onchocerca volvulus 0.0031 0.006 0.033
Brugia malayi intermediate filament protein 0.0031 0.006 0.0209
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.0049
Loa Loa (eye worm) hypothetical protein 0.0205 0.1136 0.1993
Loa Loa (eye worm) hypothetical protein 0.0156 0.0837 0.1467
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0082 0.0429
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0124 0.0164
Brugia malayi hypothetical protein 0.0022 0.0002 0.0007
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0124 0.0164
Loa Loa (eye worm) hypothetical protein 0.0384 0.2247 0.3946
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0095 0.0454 0.0452
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0124 0.0164
Brugia malayi hypothetical protein 0.0118 0.0598 0.2071
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.0219 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0479 0.2842 0.3811
Plasmodium falciparum importin beta, putative 0.0088 0.0411 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0124 0.043
Brugia malayi glutathione reductase 0.0085 0.0394 0.1364
Echinococcus multilocularis fibrillin 1 0.0026 0.003 0.0028
Loa Loa (eye worm) hypothetical protein 0.0042 0.0124 0.0214
Brugia malayi hypothetical protein 0.0051 0.0183 0.0634
Trypanosoma brucei glucosidase, putative 0.0035 0.0082 0.0154
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.0049
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0219 0.0777
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0124 0.0164
Schistosoma mansoni alpha glucosidase 0.0035 0.0082 0.0108
Loa Loa (eye worm) intermediate filament protein 0.0031 0.006 0.0102
Echinococcus granulosus Smad4 0.0033 0.0071 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0124 0.043
Leishmania major C-8 sterol isomerase-like protein 0.0384 0.2247 1
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0026 0.003 0.0049
Loa Loa (eye worm) hypothetical protein 0.0088 0.0411 0.0719
Loa Loa (eye worm) hypothetical protein 0.0042 0.0124 0.0214
Schistosoma mansoni lamin 0.0031 0.006 0.0078
Echinococcus multilocularis importin subunit beta 1 0.0088 0.0411 0.0409
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0219 0.2167
Mycobacterium tuberculosis Conserved protein 0.0156 0.0837 0.1309
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0127 0.1
Schistosoma mansoni Smad4 0.0033 0.0071 0.0093
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0124 0.043
Loa Loa (eye worm) hypothetical protein 0.0031 0.006 0.0102
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0065 0.0267 0.0994
Echinococcus granulosus GPCR family 2 0.0095 0.0454 0.0606
Loa Loa (eye worm) thioredoxin reductase 0.0085 0.0394 0.0689
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0124 0.0164
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0082 0.0429
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0071 0.0069
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0082 0.0141
Loa Loa (eye worm) hypothetical protein 0.0156 0.0837 0.1467
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0127 0.0168
Mycobacterium tuberculosis Probable esterase LipL 0.0156 0.0837 0.1309
Loa Loa (eye worm) beta-lactamase 0.0156 0.0837 0.1467
Brugia malayi steroid hormone receptor 0.0042 0.0124 0.043
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0127 0.3607
Schistosoma mansoni hypothetical protein 0.0095 0.0454 0.0606
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0124 0.0164
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0124 0.0214
Brugia malayi MH1 domain containing protein 0.0033 0.0071 0.0247
Brugia malayi Smad1 0.0033 0.0071 0.0247
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0216 0.1205 0.192
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0194 0.1071 0.1697
Leishmania major hypothetical protein, conserved 0.0051 0.0183 0.0611
Schistosoma mansoni hypothetical protein 0.0095 0.0454 0.0606
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0082 0.0429
Brugia malayi nuclear receptor RXR 0.0022 0.0002 0.0007
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0118 0.0598 0.0596
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0049 0.0062
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0124 0.0164
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0124 0.1017
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0183 0.0611
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0127 0.0168
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0323 0.0431
Schistosoma mansoni P2X receptor subunit 0.0071 0.0304 0.0406
Schistosoma mansoni hypothetical protein 0.0205 0.1136 0.1522
Entamoeba histolytica Ran family GTPase 0.0065 0.0267 0.3583
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0071 0.0122
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0065 0.0267 1
Brugia malayi follicle stimulating hormone receptor 0.0226 0.1269 0.4397
Echinococcus granulosus smad 0.0033 0.0071 0.0093
Loa Loa (eye worm) hypothetical protein 0.0042 0.0124 0.0214
Echinococcus granulosus p2X purinoceptor 4 0.0071 0.0304 0.0406
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0127 0.0358
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0127 0.0358
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0085 0.0394 0.0573
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0071 0.0093
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0124 0.0164
Loa Loa (eye worm) Smad1 0.0033 0.0071 0.0122
Brugia malayi beta-lactamase family protein 0.0156 0.0837 0.2899
Echinococcus multilocularis laminin 0.0026 0.003 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0124 0.0214
Schistosoma mansoni ap endonuclease 0.0057 0.0219 0.0292
Brugia malayi Glycosyl hydrolases family 31 protein 0.0157 0.0843 0.292
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0065 0.0267 0.0994
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0384 0.2247 0.7783
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0118 0.0598 0.08
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0124 0.043
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0082 0.0429
Brugia malayi hypothetical protein 0.0033 0.007 0.0244
Schistosoma mansoni alpha-glucosidase 0.0135 0.0707 0.0946
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0157 0.0843 0.1478
Schistosoma mansoni smad1 5 8 and 0.0033 0.0071 0.0093
Brugia malayi RNA binding protein 0.0074 0.0323 0.112
Loa Loa (eye worm) hypothetical protein 0.0042 0.0124 0.0214
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0124 0.0164
Loa Loa (eye worm) hypothetical protein 0.0156 0.0837 0.1467
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.0049
Loa Loa (eye worm) hypothetical protein 0.0196 0.1083 0.19
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0124 0.0122
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0479 0.2842 0.284
Echinococcus granulosus p2X purinoceptor 4 0.0071 0.0304 0.0406
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0124 0.043
Trichomonas vaginalis penicillin-binding protein, putative 0.0156 0.0837 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0127 0.0358
Onchocerca volvulus 0.0091 0.0431 0.4325
Brugia malayi Thioredoxin reductase 0.0085 0.0394 0.1364
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0999 0.6071 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0479 0.2842 0.284
Mycobacterium tuberculosis Probable dehydrogenase 0.0194 0.1071 0.1697
Leishmania major GTP-binding protein, putative 0.0065 0.0267 0.0994
Loa Loa (eye worm) RNA binding protein 0.0074 0.0323 0.0565
Loa Loa (eye worm) MH2 domain-containing protein 0.0487 0.2887 0.5071
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0219 0.0382
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0124 0.0164
Schistosoma mansoni smad 0.0033 0.0071 0.0093
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0049 0.0232
Toxoplasma gondii exonuclease III APE 0.0057 0.0219 0.2349
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0124 0.0122
Brugia malayi MH2 domain containing protein 0.0033 0.0071 0.0247
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0082 0.0429
Brugia malayi Latrophilin receptor protein 2 0.0095 0.0454 0.1571
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0026 0.003 0.0049
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0299 0.1724 0.3027
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0124 0.0122
Echinococcus multilocularis Tolloid protein 1 0.0026 0.003 0.0028
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0124 0.0164
Brugia malayi N-terminal motif family protein 0.0176 0.0957 0.3314
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0002 0.0007
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0219 0.0777
Echinococcus granulosus geminin 0.1222 0.7453 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0124 0.043
Trypanosoma cruzi hypothetical protein, conserved 0.0156 0.0837 0.3586
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0124 0.0164
Echinococcus granulosus lamin dm0 0.0031 0.006 0.0078
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0124 0.0122
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0156 0.0837 1
Mycobacterium ulcerans esterase/lipase LipP 0.0156 0.0837 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0127 0.0358
Onchocerca volvulus 0.0031 0.006 0.033
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0194 0.1071 0.6348
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0156 0.0837 0.1309
Leishmania major trypanothione reductase 0.0085 0.0394 0.157
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0082 0.0651
Mycobacterium tuberculosis Probable lipase LipD 0.0156 0.0837 0.1309
Mycobacterium ulcerans hypothetical protein 0.0156 0.0837 1
Trichomonas vaginalis ran, putative 0.0065 0.0267 0.2772
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0124 0.0122
Brugia malayi latrophilin 2 splice variant baaae 0.0205 0.1136 0.3935
Trypanosoma brucei trypanothione reductase 0.0085 0.0394 0.157
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0124 0.0214
Schistosoma mansoni lamin 0.0031 0.006 0.0078
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0124 0.0164
Onchocerca volvulus 0.0156 0.0837 0.8706
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0216 0.1205 0.192
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0002 0.0007
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0183 0.3706
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0029 0.0049 0.5
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0323 0.0431
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0124 0.043
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0124 0.043
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0082 0.0429
Mycobacterium tuberculosis Conserved protein 0.0156 0.0837 0.1309
Schistosoma mansoni P2X receptor subunit 0.0071 0.0304 0.0406
Schistosoma mansoni P2X receptor subunit 0.0071 0.0304 0.0406
Echinococcus granulosus intermediate filament protein 0.0031 0.006 0.0078
Plasmodium falciparum thioredoxin reductase 0.0085 0.0394 0.9522
Trichomonas vaginalis penicillin-binding protein, putative 0.0156 0.0837 1
Brugia malayi Calcium binding EGF domain containing protein 0.0026 0.003 0.0103
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0219 0.076
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0323 0.0431
Schistosoma mansoni hypothetical protein 0.0023 0.0008 0.0008
Leishmania major hypothetical protein, conserved 0.0156 0.0837 0.3586
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0124 0.043
Plasmodium vivax thioredoxin reductase, putative 0.0085 0.0394 0.438
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.006 0.0209
Schistosoma mansoni intermediate filament proteins 0.0031 0.006 0.0078
Loa Loa (eye worm) hypothetical protein 0.0042 0.0124 0.0214
Echinococcus multilocularis p2X purinoceptor 4 0.0071 0.0304 0.0302
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0479 0.2842 0.3811
Mycobacterium tuberculosis Probable hydrolase 0.0156 0.0837 0.1309
Toxoplasma gondii HEAT repeat-containing protein 0.0088 0.0411 0.4725
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0082 0.0429
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0219 0.2167
Loa Loa (eye worm) hypothetical protein 0.0176 0.0957 0.1678
Loa Loa (eye worm) glutathione reductase 0.0085 0.0394 0.0689
Brugia malayi TAR-binding protein 0.0074 0.0323 0.112
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0124 0.043
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0127 0.0125
Echinococcus granulosus lysosomal alpha glucosidase 0.0157 0.0843 0.1128
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0479 0.2842 0.4992
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0938 0.5691 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0049 0.0046
Plasmodium vivax hypothetical protein, conserved 0.0156 0.0837 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0049 0.0168
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0057 0.0219 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0065 0.0267 0.0925
Trichomonas vaginalis D-aminoacylase, putative 0.0156 0.0837 1
Echinococcus multilocularis snurportin 1 0.0938 0.5691 0.569
Echinococcus granulosus beta LACTamase domain containing family member 0.0156 0.0837 0.112
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0082 0.0429
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0124 0.0214
Brugia malayi Fibulin-1 precursor 0.0026 0.003 0.0103
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0323 0.0431
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.0843 0.0841
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0219 0.0777
Brugia malayi MH1 domain containing protein 0.0033 0.0071 0.0247
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0071 0.0069
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0124 0.0122
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0095 0.0454 0.0606
Mycobacterium tuberculosis Probable reductase 0.0194 0.1071 0.1697
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0219 0.0292
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0082 0.0108
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.0323 0.112
Brugia malayi nuclear receptor NHR-88 0.0042 0.0124 0.043
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0384 0.2247 1
Echinococcus multilocularis smad 0.0033 0.0071 0.0069
Brugia malayi Importin beta-1 subunit 0.0088 0.0411 0.1424
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0127 0.0168
Loa Loa (eye worm) hypothetical protein 0.0156 0.0837 0.1467
Loa Loa (eye worm) hypothetical protein 0.0031 0.0057 0.0096
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0026 0.003 0.0103
Trichomonas vaginalis esterase, putative 0.0156 0.0837 1
Entamoeba histolytica hypothetical protein 0.0118 0.0598 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0124 0.043
Echinococcus multilocularis p2X purinoceptor 4 0.0071 0.0304 0.0302
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0127 0.0168
Schistosoma mansoni hypothetical protein 0.0095 0.0454 0.0606
Mycobacterium tuberculosis Probable oxidoreductase 0.0216 0.1205 0.192
Echinococcus granulosus p2X purinoceptor 4 0.0071 0.0304 0.0406
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0124 0.0214
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0183 0.3706
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0124 0.1017
Echinococcus multilocularis p2X purinoceptor 4 0.0071 0.0304 0.0302
Brugia malayi ecdysteroid receptor 0.0042 0.0124 0.043
Loa Loa (eye worm) hypothetical protein 0.0299 0.1724 0.3027
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0065 0.0267 0.0466
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0049 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0124 0.043
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0082 0.0429
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0219 0.2658
Schistosoma mansoni hypothetical protein 0.1222 0.7453 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0124 0.0214
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0095 0.0454 0.0606
Echinococcus multilocularis lamin 0.0031 0.006 0.0058
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.0049
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0479 0.2842 0.3811
Loa Loa (eye worm) hypothetical protein 0.0042 0.0124 0.0214
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0127 0.0873
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0127 0.0168
Entamoeba histolytica hypothetical protein 0.0118 0.0598 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0065 0.0267 0.0994
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0124 0.0164
Plasmodium vivax importin-beta 2, putative 0.0088 0.0411 0.46
Echinococcus multilocularis thioredoxin glutathione reductase 0.0086 0.0397 0.0395
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0124 0.0164
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0124 0.0214
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0124 0.043
Schistosoma mansoni ap endonuclease 0.0057 0.0219 0.0292
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0124 0.0122
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0082 0.0154
Schistosoma mansoni hypothetical protein 0.0095 0.0454 0.0606
Schistosoma mansoni transcription factor LCR-F1 0.0118 0.0598 0.08
Schistosoma mansoni importin beta-1 0.0088 0.0411 0.0549
Brugia malayi RNA, U transporter 1 0.025 0.1417 0.4909
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0026 0.003 0.0049
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0008 0.0006
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0124 0.0164
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0479 0.2842 0.3811
Echinococcus granulosus GTP binding nuclear protein Ran 0.0065 0.0267 0.0356
Loa Loa (eye worm) TAR-binding protein 0.0074 0.0323 0.0565
Trypanosoma cruzi trypanothione reductase, putative 0.0085 0.0394 0.157
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0124 0.0122
Mycobacterium ulcerans lipase LipD 0.0156 0.0837 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0156 0.0837 0.112
Entamoeba histolytica hypothetical protein 0.0118 0.0598 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0127 0.1
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0124 0.1017
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0479 0.2842 0.9843
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0124 0.0164
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0065 0.0267 0.294
Schistosoma mansoni egf-like domain protein 0.0026 0.003 0.0037
Loa Loa (eye worm) hypothetical protein 0.0042 0.0124 0.0214
Schistosoma mansoni hypothetical protein 0.0938 0.5691 0.7635
Loa Loa (eye worm) hypothetical protein 0.0051 0.0183 0.0318
Brugia malayi beta-lactamase family protein 0.0156 0.0837 0.2899
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0065 0.0267 0.6027
Echinococcus granulosus thioredoxin glutathione reductase 0.0086 0.0397 0.053
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0176 0.0957 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0219 0.7818
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0183 0.1705
Trypanosoma brucei C-8 sterol isomerase, putative 0.0384 0.2247 1
Echinococcus granulosus tar DNA binding protein 0.0074 0.0323 0.0431
Echinococcus granulosus Tolloid protein 1 0.0026 0.003 0.0037
Echinococcus multilocularis tar DNA binding protein 0.0074 0.0323 0.0321
Onchocerca volvulus 0.0156 0.0837 0.8706
Schistosoma mansoni ran 0.0065 0.0267 0.0356
Brugia malayi Calcitonin receptor-like protein seb-1 0.0299 0.1724 0.5971
Loa Loa (eye worm) transcription factor SMAD2 0.0487 0.2887 0.5071
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.0049
Trypanosoma cruzi hypothetical protein, conserved 0.0156 0.0837 0.3586
Trypanosoma cruzi importin beta-1 subunit, putative 0.0071 0.0308 0.118
Onchocerca volvulus 0.0156 0.0837 0.8706
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.006 0.0102
Entamoeba histolytica hypothetical protein 0.0071 0.0308 0.4375
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0082 0.0285
Leishmania major importin beta-1 subunit, putative 0.0071 0.0308 0.118
Trypanosoma brucei importin beta-1 subunit, putative 0.0088 0.0411 0.1649
Schistosoma mansoni hypothetical protein 0.1222 0.7453 1
Schistosoma mansoni ran 0.0065 0.0267 0.0356
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.0323 0.0565
Trichomonas vaginalis importin beta-1, putative 0.0071 0.0308 0.3291
Schistosoma mansoni coup transcription factor 0.0042 0.0124 0.0164
Schistosoma mansoni P2X receptor subunit 0.0071 0.0304 0.0406
Echinococcus granulosus laminin 0.0026 0.003 0.0037
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0127 0.0125
Echinococcus multilocularis GPCR, family 2 0.0095 0.0454 0.0452
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0127 0.0125
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0156 0.0837 0.1309
Loa Loa (eye worm) hypothetical protein 0.0156 0.0837 0.1467
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0156 0.0837 0.112
Schistosoma mansoni smad1 5 8 and 0.0033 0.0071 0.0093
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0127 0.1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0299 0.1724 0.5971
Echinococcus granulosus importin subunit beta 1 0.0088 0.0411 0.0549
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0095 0.0454 0.0452
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0216 0.1205 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0226 0.1269 0.2228
Loa Loa (eye worm) hypothetical protein 0.0095 0.0454 0.0794
Entamoeba histolytica hypothetical protein 0.0118 0.0598 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.0219 0.0284
Brugia malayi hypothetical protein 0.0022 0.0002 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0124 0.043
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0082 0.0154
Trichomonas vaginalis D-aminoacylase, putative 0.0156 0.0837 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0124 0.043
Echinococcus multilocularis Smad4 0.0033 0.0071 0.0069

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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