Detailed information for compound 1071648

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 595.69 | Formula: C30H41N7O6
  • H donors: 5 H acceptors: 4 LogP: -2.91 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@H]([C@@H]([C@H]2O)OCc2ccccn2)N)[C@@H]([C@H]([C@@H]1OCc1ccccn1)OCc1ccccn1)N
  • InChi: 1S/C30H41N7O6/c31-14-23-28(40-16-19-8-2-5-11-36-19)29(41-17-20-9-3-6-12-37-20)24(34)30(42-23)43-27-22(33)13-21(32)26(25(27)38)39-15-18-7-1-4-10-35-18/h1-12,21-30,38H,13-17,31-34H2/t21-,22+,23-,24-,25-,26+,27-,28-,29-,30-/m1/s1
  • InChiKey: SSYXODQQGHPWTP-YKFWBMAGSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cell death protein 3 precursor 0.0054 0.135 0.1616
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0024 0.0396 0.0429
Trypanosoma brucei phosphoglycerate kinase, putative 0.0064 0.1648 0.2344
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0784 0.0784
Echinococcus granulosus citrate lyase subunit beta protein 0.0025 0.0441 0.0441
Echinococcus multilocularis dna polymerase kappa 0.0081 0.2195 0.2195
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.2195 0.322
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.135 0.1347
Giardia lamblia Sentrin 0.0053 0.132 0.232
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.132 0.131
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0174 0.5072 0.7832
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0034 0.0704 0.0704
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0044 0.1031 0.1059
Echinococcus granulosus ubiquitin 0.0033 0.0686 0.0686
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0174 0.5072 0.5
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.135 0.1347
Giardia lamblia DINP protein human, muc B family 0.0061 0.1559 0.281
Plasmodium falciparum metacaspase-like protein 0.0054 0.135 0.2382
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0441 0.0409
Trypanosoma brucei unspecified product 0.0037 0.0826 0.1026
Schistosoma mansoni ap endonuclease 0.0019 0.026 0.026
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0064 0.1648 0.2344
Trypanosoma cruzi small ubiquitin protein, putative 0.0053 0.132 0.1817
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.135 0.1347
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0441 0.0312
Loa Loa (eye worm) hypothetical protein 0.0174 0.5072 0.5995
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0877 0.0877
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0258 0.0146
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.026 0.0311
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0904 0.147
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0784 0.0784
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1559 0.2201
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.1179 0.1179
Schistosoma mansoni hypothetical protein 0.0301 0.9 0.9
Mycobacterium ulcerans hypothetical protein 0.0025 0.0441 0.0312
Plasmodium falciparum small ubiquitin-related modifier 0.0053 0.132 0.232
Leishmania major phosphoglycerate kinase C, glycosomal 0.0174 0.5072 0.7832
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.1389 0.1389
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0064 0.1648 0.2344
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0174 0.5072 1
Trypanosoma cruzi metacaspase, putative 0.0054 0.135 0.1865
Loa Loa (eye worm) hypothetical protein 0.003 0.0589 0.0519
Schistosoma mansoni hypothetical protein 0.0016 0.0164 0.0164
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0041 0.0929 0.152
Brugia malayi Bloom's syndrome protein homolog 0.0046 0.1104 0.1321
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0433 0.0395
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.1761 0.3118
Brugia malayi Phosphoglycerate kinase 0.0064 0.1648 0.1973
Echinococcus multilocularis caspase 3 0.0074 0.1974 0.1974
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0258 0.0146
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.135 0.1347
Leishmania major metacaspase, putative 0.0054 0.135 0.1865
Brugia malayi hypothetical protein 0.0033 0.0686 0.0821
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.135 0.1347
Trypanosoma brucei DNA polymerase IV, putative 0.0081 0.2195 0.322
Loa Loa (eye worm) hypothetical protein 0.0051 0.1247 0.1323
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0174 0.5072 1
Trypanosoma cruzi hypothetical protein, conserved 0.0218 0.6424 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.135 0.1448
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0174 0.5072 0.5947
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.1017 0.1701
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.1031 0.1355
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.2195 0.322
Brugia malayi glutaminase DH11.1 0.028 0.8351 1
Onchocerca volvulus Cell death protein 3 homolog 0.0054 0.135 0.1581
Toxoplasma gondii small ubiquitin family modifier, putative 0.0053 0.132 0.232
Schistosoma mansoni caspase-3 (C14 family) 0.0129 0.3661 0.3661
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.1179 0.1179
Toxoplasma gondii exonuclease III APE 0.0019 0.026 0.0152
Loa Loa (eye worm) hypothetical protein 0.0185 0.54 0.6396
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0053 0.132 0.132
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0258 0.0258
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.135 0.1347
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0054 0.135 0.1616
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0025 0.0441 0.0312
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.135 0.1347
Trypanosoma cruzi small ubiquitin protein, putative 0.0053 0.132 0.1817
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.2195 0.322
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.135 0.1347
Loa Loa (eye worm) hypothetical protein 0.0054 0.135 0.1448
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.026 0.0152
Trypanosoma cruzi metacaspase, putative 0.0054 0.135 0.1865
Mycobacterium ulcerans glutaminase 0.028 0.8351 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.135 0.1347
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.1761 0.1761
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0164 0.0164
Brugia malayi ImpB/MucB/SamB family protein 0.008 0.2159 0.2585
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0589 0.0589
Schistosoma mansoni phd finger protein 0.0013 0.0078 0.0078
Giardia lamblia Phosphoglycerate kinase 0.0174 0.5072 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.1389 0.1662
Chlamydia trachomatis phosphoglycerate kinase 0.0174 0.5072 0.5
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.1017 0.0936
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0064 0.1648 0.2344
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0952 0.0952
Schistosoma mansoni hypothetical protein 0.0016 0.0164 0.0164
Echinococcus multilocularis citrate lyase subunit beta protein 0.0025 0.0441 0.0441
Echinococcus multilocularis phosphoglycerate kinase 1 0.0174 0.5072 0.5072
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.135 0.1347
Loa Loa (eye worm) MBCTL1 0.0056 0.1389 0.1496
Entamoeba histolytica deoxycytidyl transferase, putative 0.0054 0.1349 0.2263
Schistosoma mansoni hypothetical protein 0.003 0.0589 0.0589
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0031 0.0637 0.0923
Trichomonas vaginalis DNA polymerase eta, putative 0.0081 0.2195 0.2391
Loa Loa (eye worm) hypothetical protein 0.008 0.2159 0.2437
Schistosoma mansoni DNA polymerase eta 0.008 0.2159 0.2159
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0433 0.0395
Loa Loa (eye worm) hypothetical protein 0.0019 0.0258 0.0114
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0129 0.3661 0.3661
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.026 0.0119
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.1389 0.1389
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0174 0.5072 1
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0034 0.0704 0.0704
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.1761 0.1761
Loa Loa (eye worm) hypothetical protein 0.0033 0.0686 0.0638
Schistosoma mansoni hypothetical protein 0.0173 0.5034 0.5034
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.2195 0.322
Schistosoma mansoni SET domain protein 0.0034 0.0704 0.0704
Echinococcus granulosus dna polymerase eta 0.008 0.2159 0.2159
Loa Loa (eye worm) RecQ helicase 0.0046 0.1104 0.1148
Loa Loa (eye worm) glutaminase 0.028 0.8351 1
Echinococcus granulosus peregrin 0.0043 0.1005 0.1005
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0258 0.0258
Trypanosoma brucei unspecified product 0.0075 0.1985 0.2884
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0433 0.0213
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.1761 0.2108
Plasmodium vivax phosphoglycerate kinase, putative 0.0174 0.5072 1
Brugia malayi polk-prov protein 0.0044 0.1031 0.1235
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0784 0.0758
Mycobacterium tuberculosis Conserved hypothetical protein 0.0054 0.1349 0.2263
Brugia malayi Phosphoglycerate kinase 0.0174 0.5072 0.6073
Loa Loa (eye worm) hypothetical protein 0.0051 0.1251 0.1328
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0784 0.0784
Trypanosoma cruzi metacaspase, putative 0.0054 0.135 0.1865
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0258 0.0308
Trypanosoma brucei DNA polymerase eta, putative 0.008 0.2159 0.3163
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.1761 0.1761
Trypanosoma brucei Metacaspase-4 0.0054 0.135 0.1865
Echinococcus granulosus dna polymerase kappa 0.0081 0.2195 0.2195
Schistosoma mansoni terminal deoxycytidyl transferase 0.0054 0.1349 0.1349
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.026 0.0118
Mycobacterium ulcerans DNA polymerase IV 0.0081 0.2195 0.246
Schistosoma mansoni caspase-7 (C14 family) 0.0054 0.135 0.135
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.135 0.1347
Brugia malayi PHD-finger family protein 0.003 0.0589 0.0705
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0746 0.0893
Entamoeba histolytica ubiquitin like protein 0.0053 0.132 0.2202
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.1761 0.2524
Brugia malayi N-terminal motif family protein 0.0185 0.54 0.6467
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0054 0.1349 0.1349
Echinococcus multilocularis caspase 8 0.0054 0.135 0.135
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0904 0.1339
Echinococcus granulosus caspase 3 0.0074 0.1974 0.1974
Giardia lamblia PHD finger protein 15 0.003 0.0589 0.0825
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.135 0.1347
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.1179 0.1179
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0174 0.5072 0.7832
Schistosoma mansoni glutaminase 0.028 0.8351 0.8351
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0626 0.0899
Echinococcus multilocularis caspase 0.0129 0.3661 0.3661
Loa Loa (eye worm) hypothetical protein 0.0141 0.4044 0.4739
Trypanosoma brucei metacaspase MCA3 0.0054 0.135 0.1865
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0054 0.135 0.2382
Mycobacterium ulcerans hypothetical protein 0.0025 0.0441 0.0312
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0164 0.0196
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.1179 0.1225
Plasmodium vivax hypothetical protein, conserved 0.0054 0.135 0.2382
Leishmania major DNA polymerase eta, putative 0.008 0.2159 0.3163
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0164 0.0196
Trypanosoma brucei unspecified product 0.0037 0.0826 0.1026
Echinococcus multilocularis Small ubiquitin modifier 2 0.0053 0.132 0.132
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.2195 0.322
Trypanosoma brucei hypothetical protein, conserved 0.0218 0.6424 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.2195 0.322
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.1179 0.1179
Plasmodium vivax hypothetical protein, conserved 0.003 0.0589 0.0825
Treponema pallidum phosphoglycerate kinase 0.0174 0.5072 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0164 0.0164
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0054 0.135 0.2382
Brugia malayi Bromodomain containing protein 0.0033 0.0702 0.084
Echinococcus multilocularis GPCR, family 2 0.0016 0.0164 0.0164
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.4269 0.4269
Leishmania major DNA polymerase kappa, putative 0.0061 0.1559 0.2201
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.1179 0.1179
Echinococcus granulosus caspase 0.0129 0.3661 0.3661
Trichomonas vaginalis DNA helicase recq, putative 0.0046 0.1104 0.1042
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.1247 0.1493
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0061 0.1559 0.2699
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0054 0.1349 0.1349
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.026 0.0152
Leishmania major DNA polymerase eta, putative 0.0043 0.0996 0.1298
Onchocerca volvulus 0.0049 0.1179 0.1225
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.2195 0.322
Echinococcus granulosus caspase 2 0.0054 0.135 0.135
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0904 0.147
Trypanosoma cruzi metacaspase 5, putative 0.0054 0.135 0.1865
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.1761 0.2524
Echinococcus multilocularis peregrin 0.0043 0.1005 0.1005
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0441 0.0409
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0164 0.0164
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.2195 0.322
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.026 0.0119
Schistosoma mansoni jumonji domain containing protein 0.0078 0.2074 0.2074
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0433 0.0395
Schistosoma mansoni hypothetical protein 0.0016 0.0164 0.0164
Schistosoma mansoni DNA polymerase IV / kappa 0.0017 0.0186 0.0186
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.1576 0.1725
Echinococcus granulosus histone acetyltransferase KAT2B 0.0144 0.414 0.414
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.1036 0.1362
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.1389 0.1389
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.1036 0.1362
Echinococcus granulosus phosphoglycerate kinase 1 0.0174 0.5072 0.5072
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.1389 0.1389
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.026 0.0152
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.1017 0.1701
Schistosoma mansoni ap endonuclease 0.0019 0.026 0.026
Plasmodium vivax metacaspase 1, putative 0.0054 0.135 0.2382
Trypanosoma brucei phosphoglycerate kinase 0.0174 0.5072 0.7832
Echinococcus granulosus Small ubiquitin modifier 2 0.0053 0.132 0.132
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0258 0.0114
Entamoeba histolytica hypothetical protein 0.0033 0.0686 0.0884
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.135 0.1347
Trichomonas vaginalis ubiquitin, putative 0.0033 0.0686 0.0526
Echinococcus multilocularis ubiquitin 0.0033 0.0686 0.0686
Echinococcus granulosus GPCR family 2 0.0016 0.0164 0.0164
Schistosoma mansoni hypothetical protein 0.0035 0.0746 0.0746
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0174 0.5072 0.5947
Trypanosoma brucei small ubiquitin-related modifier 0.0053 0.132 0.1817
Leishmania major small ubiquitin protein, putative 0.0053 0.132 0.1817
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0996 0.1298
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0064 0.1648 0.2344
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.026 0.0119
Mycobacterium ulcerans phosphoglycerate kinase 0.0174 0.5072 0.5984
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.1247 0.1493
Trypanosoma cruzi DNA polymerase eta, putative 0.008 0.2159 0.3163
Brugia malayi jmjC domain containing protein 0.0036 0.0784 0.0939
Trichomonas vaginalis DNA helicase recq1, putative 0.0046 0.1104 0.1042
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0129 0.3661 0.3661
Trypanosoma brucei metacaspase MCA2 0.0054 0.135 0.1865
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.026 0.026
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0589 0.0519
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0185 0.54 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0589 0.0589
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.135 0.1347
Plasmodium falciparum phosphoglycerate kinase 0.0174 0.5072 1
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.135 0.1347
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0025 0.0441 0.0376
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0877 0.0877
Mycobacterium ulcerans DNA polymerase IV 0.0081 0.2195 0.246
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0064 0.1648 0.2344
Brugia malayi jmjC domain containing protein 0.0098 0.2697 0.323
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.026 0.026
Echinococcus granulosus bloom syndrome protein 0.0046 0.1104 0.1104
Entamoeba histolytica phosphoglycerate kinase, putative 0.0174 0.5072 1
Loa Loa (eye worm) glutaminase 2 0.028 0.8351 1
Trypanosoma brucei phosphoglycerate kinase 0.0174 0.5072 0.7832
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0196 0.5758 0.5758
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0054 0.135 0.2382
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.1247 0.1323
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.1179 0.1179
Trypanosoma brucei metacaspase 0.0054 0.135 0.1865
Trypanosoma cruzi metacaspase, putative 0.0054 0.135 0.1865
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0081 0.2195 0.2391
Onchocerca volvulus 0.0033 0.0686 0.0201
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.1179 0.1179
Schistosoma mansoni DNA helicase recq1 0.0019 0.0258 0.0258
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.1761 0.195
Schistosoma mansoni hypothetical protein 0.0016 0.0164 0.0164
Leishmania major hypothetical protein, conserved 0.0218 0.6424 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0054 0.1349 0.1448
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0054 0.1349 0.1349
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0258 0.0146
Trypanosoma brucei metacaspase 5, putative 0.0054 0.135 0.1865
Plasmodium falciparum phd finger protein, putative 0.003 0.0589 0.0825
Plasmodium vivax small ubiquitin-related modifier, putative 0.0053 0.132 0.232
Schistosoma mansoni DNA helicase recq5 0.0019 0.0258 0.0258
Loa Loa (eye worm) SMO-1 protein 0.0053 0.132 0.1412
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0441 0.0409
Schistosoma mansoni blooms syndrome DNA helicase 0.0037 0.0801 0.0801
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.1036 0.1362
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.1761 0.2524
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.2195 0.322
Loa Loa (eye worm) acetyltransferase 0.0148 0.4269 0.5014
Trypanosoma brucei DNA polymerase IV, putative 0.0081 0.2195 0.322
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.1017 0.1017
Trypanosoma cruzi hypothetical protein, conserved 0.0218 0.6424 1
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.4269 0.5112
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0686 0.0526
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0589 0.0589
Echinococcus granulosus caspase 8 0.0054 0.135 0.135
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0441 0.0312
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.2195 0.322
Schistosoma mansoni caspase-7 (C14 family) 0.0129 0.3661 0.3661
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.2697 0.2697
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.1349 0.1615
Plasmodium falciparum metacaspase 1 0.0054 0.135 0.2382
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.026 0.0091
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.1017 0.0936
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.1761 0.2524
Loa Loa (eye worm) hypothetical protein 0.0056 0.1389 0.1496
Echinococcus multilocularis bloom syndrome protein 0.0046 0.1104 0.1104
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0064 0.1648 0.2344
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0589 0.0825
Echinococcus multilocularis dna polymerase eta 0.008 0.2159 0.2159
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0061 0.1559 0.2201
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0784 0.0784
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.4269 0.4269
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.2195 0.322
Brugia malayi Ubiquitin-like protein SMT3 0.0053 0.132 0.158
Brugia malayi mbt repeat family protein 0.0049 0.1179 0.1411
Echinococcus multilocularis caspase 2 0.0054 0.135 0.135
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0258 0.0258
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.2195 0.322
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0952 0.0952
Schistosoma mansoni phosphoglycerate kinase 0.0174 0.5072 0.5072
Trypanosoma brucei DNA polymerase IV, putative 0.0075 0.1985 0.2884
Loa Loa (eye worm) hypothetical protein 0.0049 0.1179 0.1239
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.1017 0.1701
Trichomonas vaginalis glutaminase, putative 0.028 0.8351 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.2697 0.2697
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0196 0.5758 0.5758
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.1179 0.1239
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0054 0.135 0.135
Schistosoma mansoni phosphoglycerate kinase 0.0174 0.5072 0.5072
Entamoeba histolytica recQ family helicase, putative 0.0025 0.0433 0.0358
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.1389 0.1389
Trypanosoma brucei phosphoglycerate kinase 0.0064 0.1648 0.2344
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0025 0.0441 0.0224
Mycobacterium tuberculosis Conserved protein 0.0025 0.0441 0.0376
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0174 0.5072 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.2195 0.322
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0258 0.0308
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.0996 0.1657
Leishmania major phosphoglycerate kinase B, cytosolic 0.0174 0.5072 0.7832
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0164 0.0164
Brugia malayi mbt repeat family protein 0.0049 0.1179 0.1411
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0258 0.0146
Trypanosoma cruzi metacaspase 5, putative 0.0054 0.135 0.1865
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0589 0.0825
Loa Loa (eye worm) hypothetical protein 0.0035 0.0746 0.0711
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.026 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.1031 0.1355

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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