Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | muscleblind protein | 0.0458 | 0.2468 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0025 | 0.0103 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0026 | 0.0117 |
Echinococcus granulosus | ferritin | 0.0009 | 0.0026 | 0.0106 |
Trypanosoma brucei | recA bacterial DNA recombination protein, putative | 0.0035 | 0.0167 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0178 | 0.5 |
Echinococcus multilocularis | ferritin | 0.0009 | 0.0026 | 0.0057 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0842 | 0.4555 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0005 | 0.002 |
Echinococcus multilocularis | expressed protein | 0.0009 | 0.0026 | 0.0057 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0028 | 0.0113 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0147 | 0.0657 |
Schistosoma mansoni | ferritin light chain | 0.0009 | 0.0026 | 0.0117 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0008 | 0.0025 | 0.0056 |
Treponema pallidum | recombinase A | 0.0112 | 0.0588 | 1 |
Echinococcus granulosus | dnaJ subfamily B | 0.0415 | 0.2231 | 0.904 |
Echinococcus multilocularis | smad | 0.0008 | 0.0025 | 0.0056 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0232 | 0.0939 |
Brugia malayi | MH2 domain containing protein | 0.0124 | 0.0653 | 0.2646 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0004 | 0.0002 | 0.001 |
Schistosoma mansoni | hypothetical protein | 0.0415 | 0.2231 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0232 | 0.1038 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.0025 | 0.0103 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0658 | 0.3551 | 1 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.0025 | 0.0103 |
Trypanosoma cruzi | DNA repair protein, putative | 0.0035 | 0.0167 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0147 | 0.0657 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0028 | 0.0115 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0178 | 0.0719 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0028 | 0.0062 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0232 | 0.0509 |
Chlamydia trachomatis | recombinase RecA | 0.0112 | 0.0588 | 0.5 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0026 | 0.0117 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0178 | 0.5 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.0138 | 0.0557 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0025 | 0.0114 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0138 | 0.0617 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0025 | 0.0103 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0232 | 0.0939 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0025 | 0.0114 |
Brugia malayi | MH1 domain containing protein | 0.0005 | 0.0005 | 0.002 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.0025 | 0.0103 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0124 | 0.0653 | 0.2646 |
Schistosoma mansoni | ferritin light chain | 0.0009 | 0.0026 | 0.0117 |
Brugia malayi | Smad1 | 0.0008 | 0.0025 | 0.0103 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0026 | 0.0117 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0178 | 0.039 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0232 | 0.1038 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0025 | 0.0103 |
Onchocerca volvulus | 0.0029 | 0.0138 | 1 | |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0019 | 0.0076 |
Trypanosoma cruzi | DNA repair protein, putative | 0.0035 | 0.0167 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0232 | 0.0939 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0124 | 0.0653 | 0.2646 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0178 | 0.5 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.0138 | 0.0557 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0232 | 0.0939 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0019 | 0.0084 |
Echinococcus multilocularis | Smad4 | 0.0008 | 0.0025 | 0.0056 |
Wolbachia endosymbiont of Brugia malayi | recombinase A | 0.0112 | 0.0588 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0178 | 0.0796 |
Brugia malayi | Muscleblind-like protein | 0.0458 | 0.2468 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0458 | 0.2468 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0458 | 0.2468 | 0.5419 |
Echinococcus multilocularis | muscleblind protein | 0.0458 | 0.2468 | 0.5419 |
Loa Loa (eye worm) | hypothetical protein | 0.0458 | 0.2468 | 1 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0028 | 0.0115 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.0025 | 0.0114 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0178 | 0.0719 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0019 | 0.0041 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0025 | 0.0114 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0008 | 0.0025 | 0.0103 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0008 | 0.0025 | 0.0056 |
Brugia malayi | MH1 domain containing protein | 0.0005 | 0.0005 | 0.002 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0025 | 0.0114 |
Echinococcus multilocularis | cpg binding protein | 0.0031 | 0.0147 | 0.0322 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0415 | 0.2231 | 0.4899 |
Trichomonas vaginalis | ferritin, putative | 0.0009 | 0.0026 | 1 |
Schistosoma mansoni | apoferritin-2 | 0.0009 | 0.0026 | 0.0117 |
Schistosoma mansoni | apoferritin-2 | 0.0009 | 0.0026 | 0.0117 |
Mycobacterium leprae | RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. | 0.0112 | 0.0588 | 0.1595 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0055 | 0.0279 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0025 | 0.0103 |
Mycobacterium ulcerans | recombinase A | 0.0112 | 0.0588 | 1 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0026 | 0.0117 |
Echinococcus granulosus | smad | 0.0008 | 0.0025 | 0.0103 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0008 | 0.0025 | 0.0103 |
Mycobacterium tuberculosis | Probable replicative DNA helicase DnaB | 0.1733 | 0.9391 | 0.939 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0062 | 0.0315 | 0.1411 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0178 | 0.5 |
Echinococcus granulosus | cpg binding protein | 0.0031 | 0.0147 | 0.0594 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0178 | 0.0796 |
Echinococcus granulosus | expressed protein | 0.0009 | 0.0026 | 0.0106 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0232 | 0.0509 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0232 | 0.1038 |
Loa Loa (eye worm) | nuclear factor I | 0.0005 | 0.0005 | 0.002 |
Echinococcus granulosus | Smad4 | 0.0008 | 0.0025 | 0.0103 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0007 | 0.0019 | 0.0076 |
Schistosoma mansoni | smad | 0.0008 | 0.0025 | 0.0114 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0007 | 0.0019 | 0.0041 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 74.7 % | Antileishmanial activity against Leishmania donovani in luciferase-promastigote system at 10 ug/ml | ChEMBL. | 19692240 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.