Detailed information for compound 1072184

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 501.618 | Formula: C26H39N5O5
  • H donors: 2 H acceptors: 4 LogP: 2.05 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: ONC(=O)[C@H]1C[C@@H](CN([C@@H]1C(=O)N1CCN(CC1)c1ccccc1)C)OC(=O)N1CCCCCCC1
  • InChi: 1S/C26H39N5O5/c1-28-19-21(36-26(34)31-12-8-3-2-4-9-13-31)18-22(24(32)27-35)23(28)25(33)30-16-14-29(15-17-30)20-10-6-5-7-11-20/h5-7,10-11,21-23,35H,2-4,8-9,12-19H2,1H3,(H,27,32)/t21-,22-,23-/m0/s1
  • InChiKey: MIUJFEWUCGLALV-VABKMULXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) Starlite/ChEMBL References
Homo sapiens ADAM metallopeptidase domain 10 Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 1 (interstitial collagenase) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 3 (stromelysin 1, progelatinase) Starlite/ChEMBL References
Homo sapiens erb-b2 receptor tyrosine kinase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Disintegrin family protein Get druggable targets OG5_131201 All targets in OG5_131201
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus disintegrin and metalloproteinase Get druggable targets OG5_131201 All targets in OG5_131201
Echinococcus multilocularis disintegrin and metalloproteinase Get druggable targets OG5_131201 All targets in OG5_131201
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) TK/EGFR protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni dihydroceramide desaturase Get druggable targets OG5_131201 All targets in OG5_131201
Echinococcus multilocularis Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum ko:K04712 fatty acid desaturase, putative Get druggable targets OG5_131201 All targets in OG5_131201
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) disintegrin family protein Get druggable targets OG5_131201 All targets in OG5_131201
Schistosoma japonicum ko:K05085 receptor tyrosine-protein kinase erbB-4, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Tyrosine-protein kinase transforming protein erbB, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-2 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum expressed protein Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi Furin-like cysteine rich region family protein Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus melanoma receptor tyrosine protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-4 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Matrixin family protein matrix metallopeptidase 1 (interstitial collagenase) 403 aa 401 aa 27.7 %
Echinococcus granulosus matrix metallopeptidase 7 M10 family matrix metallopeptidase 3 (stromelysin 1, progelatinase) 477 aa 431 aa 34.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major dihydrolipoamide dehydrogenase, putative 0.006 0.0446 0.1137
Loa Loa (eye worm) hypothetical protein 0.0124 0.1205 0.1791
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0036 0.0163 0.0316
Loa Loa (eye worm) hypothetical protein 0.0093 0.0832 0.1227
Brugia malayi RNA recognition motif domain containing protein 0.0134 0.132 0.1966
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.006 0.0446 0.089
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0036 0.0163 0.0222
Plasmodium vivax hypothetical protein, conserved 0.0065 0.0497 0.2663
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.006 0.0446 0.1191
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0036 0.0163 0.0163
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0124 0.1205 0.1751
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0043 0.0238 0.0328
Echinococcus granulosus FTZ F1 alpha 0.0043 0.0238 0.0238
Schistosoma mansoni tar DNA-binding protein 0.0134 0.132 0.132
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0819 0.9467 0.9467
Schistosoma mansoni jumonji/arid domain-containing protein 0.0082 0.0699 0.0699
Echinococcus granulosus peregrin 0.0065 0.0497 0.0497
Brugia malayi Bromodomain containing protein 0.0065 0.0497 0.0719
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0368 0.0524
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0065 0.0497 0.0497
Schistosoma mansoni tyrosine kinase 0.0058 0.0414 0.0414
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0397 0.4445 0.8906
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0036 0.0163 0.0214
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0163 0.0166
Leishmania major 4-coumarate:coa ligase-like protein 0.0124 0.1205 0.3333
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0318 0.3507 0.3507
Echinococcus granulosus tar DNA binding protein 0.0134 0.132 0.132
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0028 0.006 0.006
Loa Loa (eye worm) RNA binding protein 0.0134 0.132 0.1966
Mycobacterium tuberculosis Probable dehydrogenase 0.0397 0.4445 0.893
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0088 0.0772 0.1459
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.006 0.0446 0.1191
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0163 0.0166
Schistosoma mansoni RAR-like nuclear receptor 0.0043 0.0238 0.0238
Loa Loa (eye worm) hypothetical protein 0.0043 0.0238 0.0328
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0163 0.0222
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0073 0.0598 0.1301
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0068 0.0537 0.0537
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0328 0.0465
Plasmodium falciparum glutathione reductase 0.006 0.0446 0.238
Brugia malayi PHD-finger family protein 0.0065 0.0497 0.0719
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0036 0.0163 0.0222
Brugia malayi Hemopexin family protein 0.0134 0.1326 0.1975
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.006 0.0446 0.1137
Brugia malayi Matrixin family protein 0.0095 0.0856 0.1263
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0036 0.0163 0.0222
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0036 0.0163 0.0331
Mycobacterium ulcerans acyl-CoA synthetase 0.0124 0.1205 0.1751
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0211 0.2241 0.2241
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0043 0.0238 0.0238
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0238 0.0238
Trypanosoma cruzi hypothetical protein, conserved 0.0237 0.2543 0.7555
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.006 0.0446 0.1191
Onchocerca volvulus 0.0061 0.0451 0.055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0564 0.1259
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0024 0.0018 0.0018
Toxoplasma gondii NADPH-glutathione reductase 0.006 0.0446 0.0848
Plasmodium falciparum acyl-CoA synthetase 0.0093 0.0832 0.4554
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0064 0.0492 0.1329
Mycobacterium ulcerans aldehyde dehydrogenase 0.0318 0.3507 0.5253
Schistosoma mansoni coup transcription factor 0.0043 0.0238 0.0238
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0163 0.0214
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0036 0.0163 0.0166
Onchocerca volvulus Matrilysin homolog 0.0095 0.0856 0.1322
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0036 0.0163 0.0222
Schistosoma mansoni tar DNA-binding protein 0.0134 0.132 0.132
Onchocerca volvulus 0.0095 0.0856 0.1322
Schistosoma mansoni aldehyde dehydrogenase 0.0318 0.3507 0.3507
Schistosoma mansoni acetyl-CoA synthetase 0.0036 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0093 0.0832 0.1227
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0095 0.0856 0.0856
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0238 0.0328
Schistosoma mansoni tyrosine kinase 0.0097 0.088 0.088
Brugia malayi Matrixin family protein 0.0095 0.0856 0.1263
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.006 0.0446 0.0848
Leishmania major acetyl-CoA synthetase, putative 0.0036 0.0163 0.0316
Leishmania major trypanothione reductase 0.0174 0.1797 0.5049
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0238 0.0328
Leishmania major acetyl-CoA synthetase, putative 0.0036 0.0163 0.0316
Entamoeba histolytica acyl-CoA synthetase, putative 0.0124 0.1205 0.327
Loa Loa (eye worm) matrix metalloproteinase 0.0095 0.0856 0.1263
Loa Loa (eye worm) glutaminase 2 0.058 0.6627 1
Onchocerca volvulus 0.0052 0.0353 0.0362
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0139 0.0178
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0043 0.0238 0.0238
Loa Loa (eye worm) hypothetical protein 0.0034 0.0139 0.0178
Schistosoma mansoni tyrosine kinase 0.0096 0.0868 0.0868
Loa Loa (eye worm) hypothetical protein 0.0095 0.0856 0.1263
Loa Loa (eye worm) matrixin family protein 0.0229 0.2452 0.368
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0036 0.0163 0.0166
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0238 0.0238
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0068 0.0537 0.0537
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0134 0.132 0.1966
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0564 0.1259
Schistosoma mansoni aldehyde dehydrogenase 0.0318 0.3507 0.3507
Loa Loa (eye worm) hypothetical protein 0.0124 0.1205 0.1791
Trichomonas vaginalis CAMK family protein kinase 0.0304 0.3348 0.5012
Echinococcus multilocularis adam 0.0048 0.0306 0.0306
Brugia malayi CXXC zinc finger family protein 0.0061 0.0451 0.065
Brugia malayi Furin-like cysteine rich region family protein 0.018 0.187 0.2799
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0332 0.0506
Echinococcus multilocularis thioredoxin glutathione reductase 0.0176 0.1816 0.1816
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0459 0.0459
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.026 0.2816 0.423
Echinococcus granulosus thioredoxin glutathione reductase 0.0176 0.1816 0.1816
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0459 0.0459
Entamoeba histolytica acyl-coA synthetase, putative 0.0124 0.1205 0.327
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0131 0.1286 0.1286
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0124 0.1205 0.2166
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.006 0.0446 0.238
Mycobacterium ulcerans aldehyde dehydrogenase 0.0318 0.3507 0.5253
Loa Loa (eye worm) hypothetical protein 0.005 0.0328 0.0465
Schistosoma mansoni tyrosine kinase 0.0058 0.0414 0.0414
Schistosoma mansoni tar DNA-binding protein 0.0134 0.132 0.132
Loa Loa (eye worm) thioredoxin reductase 0.0174 0.1797 0.2688
Schistosoma mansoni hypothetical protein 0.0171 0.1765 0.1765
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0038 0.0186 0.0186
Leishmania major acetoin dehydrogenase e3 component-like protein 0.006 0.0446 0.1137
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.02 0.02
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0036 0.0163 0.0222
Onchocerca volvulus 0.0061 0.0459 0.0565
Brugia malayi MH2 domain containing protein 0.0121 0.1163 0.1729
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.01 0.0918 0.0918
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0036 0.0163 0.0781
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0163 0.0166
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0043 0.0238 0.0328
Brugia malayi F/Y-rich N-terminus family protein 0.0042 0.0227 0.0311
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0564 0.1259
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0028 0.006 0.006
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0344 0.3823 0.3823
Schistosoma mansoni dihydroceramide desaturase 0.0102 0.0942 0.0942
Mycobacterium tuberculosis Probable oxidoreductase 0.0441 0.4972 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0163 0.0222
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0318 0.3507 0.7021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0088 0.0772 0.1459
Onchocerca volvulus Matrilysin homolog 0.021 0.2227 0.3937
Echinococcus granulosus disintegrin and metalloproteinase 0.0102 0.0942 0.0942
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0043 0.0238 0.0238
Brugia malayi Protein kinase domain containing protein 0.0058 0.0414 0.0594
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0093 0.0832 0.1582
Brugia malayi Pre-SET motif family protein 0.042 0.4719 0.7111
Echinococcus multilocularis insulin receptor 0.0058 0.0414 0.0414
Brugia malayi jmjC domain containing protein 0.0082 0.0699 0.1026
Onchocerca volvulus Serine\/threonine kinase homolog 0.0304 0.3348 0.6076
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0124 0.1205 0.1751
Echinococcus multilocularis jumonji domain containing protein 0.009 0.0797 0.0797
Brugia malayi glutaminase DH11.1 0.058 0.6627 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0564 0.1259
Loa Loa (eye worm) matrixin family protein 0.021 0.2227 0.3339
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0238 0.0238
Schistosoma mansoni serine/threonine protein kinase 0.0304 0.3348 0.3348
Onchocerca volvulus 0.0124 0.1205 0.1987
Toxoplasma gondii PHD-finger domain-containing protein 0.0065 0.0497 0.0998
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0238 0.0328
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0564 0.1259
Trypanosoma brucei polo-like protein kinase 0.0304 0.3348 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.006 0.0446 0.0643
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0028 0.006 0.006
Trypanosoma cruzi trypanothione reductase, putative 0.0174 0.1797 0.5292
Trichomonas vaginalis CAMK family protein kinase 0.0151 0.1521 0.2232
Echinococcus granulosus citrate lyase subunit beta protein 0.0027 0.0054 0.0054
Plasmodium falciparum thioredoxin reductase 0.0174 0.1797 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0332 0.1736
Brugia malayi photoreceptor-specific nuclear receptor 0.0043 0.0238 0.0328
Loa Loa (eye worm) hypothetical protein 0.0115 0.1101 0.1634
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0163 0.0166
Echinococcus granulosus PHD finger protein rhinoceros 0.0065 0.0497 0.0497
Entamoeba histolytica hypothetical protein 0.004 0.02 0.0118
Loa Loa (eye worm) jmjC domain-containing protein 0.0082 0.0699 0.1026
Loa Loa (eye worm) hypothetical protein 0.0095 0.0856 0.1263
Loa Loa (eye worm) reprolysin 0.0028 0.006 0.0058
Echinococcus multilocularis epidermal growth factor receptor 0.018 0.187 0.187
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0124 0.1205 0.234
Schistosoma mansoni steroid hormone receptor ad4bp 0.0043 0.0238 0.0238
Loa Loa (eye worm) PHD-finger family protein 0.0065 0.0497 0.0719
Mycobacterium ulcerans acetyl-CoA synthetase 0.0036 0.0163 0.0166
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.006 0.0446 0.0446
Schistosoma mansoni tyrosine kinase 0.0097 0.088 0.088
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0238 0.0238
Brugia malayi Matrixin family protein 0.0095 0.0856 0.1263
Echinococcus multilocularis citrate lyase subunit beta protein 0.0027 0.0054 0.0054
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0163 0.0222
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0036 0.0163 0.0166
Echinococcus granulosus L aminoadipate semialdehyde 0.026 0.2816 0.2816
Trypanosoma cruzi major cysteine proteinase, putative 0.0055 0.0385 0.1007
Mycobacterium ulcerans aldehyde dehydrogenase 0.0318 0.3507 0.5253
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0238 0.0238
Brugia malayi AMP-binding enzyme family protein 0.0124 0.1205 0.1791
Schistosoma mansoni hypothetical protein 0.0054 0.0368 0.0368
Echinococcus multilocularis thyroid hormone receptor alpha 0.0043 0.0238 0.0238
Trypanosoma cruzi polo-like protein kinase, putative 0.0304 0.3348 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0058 0.0414 0.0414
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0163 0.0214
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.006 0.0446 0.238
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0043 0.0238 0.0328
Schistosoma mansoni cpg binding protein 0.0064 0.0492 0.0492
Loa Loa (eye worm) hypothetical protein 0.0036 0.0163 0.0214
Toxoplasma gondii thioredoxin reductase 0.0174 0.1797 0.4888
Echinococcus multilocularis cpg binding protein 0.0064 0.0492 0.0492
Trypanosoma brucei hypothetical protein, conserved 0.0237 0.2543 0.7471
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0238 0.0328
Trichomonas vaginalis CAMK family protein kinase 0.0304 0.3348 0.5012
Loa Loa (eye worm) hypothetical protein 0.0061 0.0459 0.0662
Echinococcus granulosus geminin 0.0171 0.1765 0.1765
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0043 0.0238 0.0328
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0238 0.0328
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0238 0.0328
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.006 0.0446 0.089
Plasmodium vivax thioredoxin reductase, putative 0.0174 0.1797 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0564 0.1259
Loa Loa (eye worm) glutaminase 0.058 0.6627 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0073 0.0598 0.0828
Toxoplasma gondii PHD-finger domain-containing protein 0.0065 0.0497 0.0998
Leishmania major hypothetical protein, conserved 0.0051 0.0332 0.0806
Loa Loa (eye worm) glutathione reductase 0.0174 0.1797 0.2688
Mycobacterium leprae PROBABLE HYDROLASE 0.0115 0.1101 0.1951
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0031 0.0103 0.0099
Loa Loa (eye worm) hypothetical protein 0.0043 0.0238 0.0328
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0073 0.0598 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0043 0.0238 0.0328
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0043 0.0238 0.0328
Loa Loa (eye worm) hypothetical protein 0.026 0.2816 0.423
Onchocerca volvulus 0.0478 0.5406 1
Onchocerca volvulus Matrix metalloproteinase homolog 0.021 0.2227 0.3937
Loa Loa (eye worm) hypothetical protein 0.0093 0.0832 0.1227
Echinococcus granulosus epidermal growth factor receptor 0.0097 0.088 0.088
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0328 0.0465
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0043 0.0238 0.0144
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0459 0.0459
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0318 0.3507 0.3507
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0238 0.0238
Trypanosoma cruzi polo-like protein kinase, putative 0.0304 0.3348 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0073 0.0598 0.3234
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0036 0.0163 0.0214
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0073 0.0598 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0304 0.3348 0.9541
Echinococcus multilocularis tar DNA binding protein 0.0134 0.132 0.132
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0048 0.0306 0.0306
Schistosoma mansoni cpg binding protein 0.0064 0.0492 0.0492
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0043 0.0238 0.0238
Echinococcus multilocularis PHD finger protein rhinoceros 0.0065 0.0497 0.0497
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0036 0.0163 0.0166
Leishmania major 4-coumarate:coa ligase-like protein 0.0124 0.1205 0.3333
Brugia malayi Steroid receptor seven-up type 2 0.0043 0.0238 0.0328
Mycobacterium ulcerans acyl-CoA synthetase 0.0124 0.1205 0.1751
Plasmodium vivax acyl-CoA synthetase, putative 0.0093 0.0832 0.4554
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0036 0.0163 0.0331
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.042 0.4719 0.7111
Schistosoma mansoni hypothetical protein 0.0171 0.1765 0.1765
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0097 0.088 0.088
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0598 0.1365
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0043 0.0238 0.0238
Trichomonas vaginalis antibiotic synthetase, putative 0.0036 0.0163 0.0166
Brugia malayi Pre-SET motif family protein 0.0061 0.0459 0.0662
Plasmodium vivax glutathione reductase, putative 0.0174 0.1797 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0238 0.0328
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0163 0.0166
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0036 0.0163 0.0166
Echinococcus multilocularis survival motor neuron protein 1 0.0263 0.2857 0.2857
Plasmodium vivax SET domain protein, putative 0.0061 0.0459 0.2451
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0043 0.0238 0.0238
Mycobacterium ulcerans glutaminase 0.058 0.6627 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0163 0.0214
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0163 0.0214
Mycobacterium tuberculosis Probable reductase 0.0397 0.4445 0.893
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0073 0.0598 0.1106
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0332 0.0845
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.006 0.0446 0.238
Echinococcus multilocularis epidermal growth factor receptor 0.0097 0.088 0.088
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.1163 0.1729
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0304 0.3348 0.3348
Loa Loa (eye worm) TAR-binding protein 0.0134 0.132 0.1966
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0564 0.1259
Trichomonas vaginalis CAMK family protein kinase 0.0304 0.3348 0.5012
Brugia malayi TAR-binding protein 0.0134 0.132 0.1966
Brugia malayi nuclear receptor NHR-88 0.0043 0.0238 0.0328
Brugia malayi nuclear hormone receptor 0.0043 0.0238 0.0328
Loa Loa (eye worm) hypothetical protein 0.0051 0.0332 0.047
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.006 0.0446 0.238
Brugia malayi AMP-binding enzyme family protein 0.0124 0.1205 0.1791
Trichomonas vaginalis CAMK family protein kinase 0.0304 0.3348 0.5012
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0043 0.0238 0.0238
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0044 0.0256 0.0355
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0028 0.006 0.006
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0564 0.1549
Loa Loa (eye worm) hypothetical protein 0.0095 0.0856 0.1263
Brugia malayi serine/threonine-protein kinase plk-2 0.0304 0.3348 0.5036
Brugia malayi Disintegrin family protein 0.0102 0.0942 0.1394
Loa Loa (eye worm) TK/INSR protein kinase 0.0058 0.0414 0.0594
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0564 0.1259
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0058 0.0414 0.0414
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0459 0.0459
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0163 0.0166
Loa Loa (eye worm) hypothetical protein 0.0028 0.006 0.0058
Trypanosoma cruzi cruzipain precursor, putative 0.007 0.0564 0.1549
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0043 0.0238 0.0328
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0043 0.0238 0.0328
Echinococcus granulosus insulin receptor 0.0058 0.0414 0.0414
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.1163 0.1729
Schistosoma mansoni tar DNA-binding protein 0.0134 0.132 0.132
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0088 0.0772 0.1459
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0036 0.0163 0.0331
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0036 0.0163 0.0222
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0124 0.1205 0.1751
Loa Loa (eye worm) hypothetical protein 0.0065 0.0497 0.0719
Brugia malayi steroid hormone receptor 0.0043 0.0238 0.0328
Mycobacterium ulcerans acyl-CoA synthetase 0.0124 0.1205 0.1751
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.026 0.2816 0.2816
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0598 0.0904
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0174 0.1797 0.3545
Brugia malayi jmjC domain containing protein 0.0211 0.2241 0.336
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.006 0.0446 0.0446
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0332 0.1736
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.006 0.0446 0.1191
Leishmania major cathepsin L-like protease 0.007 0.0564 0.1478
Schistosoma mansoni jumonji domain containing protein 0.0168 0.1725 0.1725
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0036 0.0163 0.0166
Onchocerca volvulus Protein ultraspiracle homolog 0.0043 0.0238 0.0144
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0332 0.0532
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.006 0.0446 0.1191
Trichomonas vaginalis CAMK family protein kinase 0.0304 0.3348 0.5012
Loa Loa (eye worm) hypothetical protein 0.0043 0.0238 0.0328
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.006 0.0446 0.0597
Schistosoma mansoni tyrosine kinase 0.0096 0.0868 0.0868
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0397 0.4445 0.893
Trichomonas vaginalis mercuric reductase, putative 0.006 0.0446 0.0597
Echinococcus multilocularis ecdysone induced protein 78C 0.0043 0.0238 0.0238
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0238 0.0328
Loa Loa (eye worm) hypothetical protein 0.0263 0.2857 0.4292
Brugia malayi RNA binding protein 0.0134 0.132 0.1966
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0024 0.0018 0.0018
Brugia malayi Matrixin family protein 0.0229 0.2452 0.368
Trypanosoma cruzi trypanothione reductase, putative 0.006 0.0446 0.1191
Plasmodium falciparum phd finger protein, putative 0.0065 0.0497 0.2663
Loa Loa (eye worm) hypothetical protein 0.0111 0.1044 0.1548
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0073 0.0598 0.3234
Trichomonas vaginalis CAMK family protein kinase 0.0304 0.3348 0.5012
Echinococcus granulosus lysine specific demethylase 5A 0.0082 0.0699 0.0699
Echinococcus multilocularis disintegrin and metalloproteinase 0.0102 0.0942 0.0942
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0441 0.4972 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0397 0.4445 0.893
Trichomonas vaginalis glutaminase, putative 0.058 0.6627 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0036 0.0163 0.0214
Entamoeba histolytica hypothetical protein 0.0073 0.0598 0.1365
Schistosoma mansoni retinoic acid receptor RXR 0.0043 0.0238 0.0238
Brugia malayi hypothetical protein 0.0048 0.0306 0.043
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.006 0.0446 0.089
Onchocerca volvulus 0.026 0.2816 0.506
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0459 0.0459
Brugia malayi AMP-binding enzyme family protein 0.0124 0.1205 0.1791
Loa Loa (eye worm) hypothetical protein 0.0124 0.1205 0.1791
Loa Loa (eye worm) hypothetical protein 0.0036 0.0163 0.0214
Brugia malayi hypothetical protein 0.0033 0.0119 0.0147
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0328 0.0465
Giardia lamblia PHD finger protein 15 0.0065 0.0497 0.0173
Schistosoma mansoni cpg binding protein 0.0061 0.0451 0.0451
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0459 0.0885
Schistosoma mansoni tyrosine kinase 0.0096 0.0868 0.0868
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0036 0.0163 0.0163
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0093 0.0832 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0238 0.0328
Echinococcus granulosus jumonji domain containing protein 0.009 0.0797 0.0797
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0318 0.3507 1
Entamoeba histolytica hypothetical protein 0.004 0.02 0.0118
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0088 0.0772 0.1459
Toxoplasma gondii aldehyde dehydrogenase 0.0318 0.3507 1
Onchocerca volvulus Bile acid receptor homolog 0.0043 0.0238 0.0144
Onchocerca volvulus 0.0054 0.0368 0.0391
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0564 0.1259
Schistosoma mansoni hypothetical protein 0.0134 0.1326 0.1326
Mycobacterium ulcerans flavoprotein disulfide reductase 0.006 0.0446 0.0597
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0044 0.0256 0.0355
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.1122 0.2869
Brugia malayi hypothetical protein 0.0263 0.2857 0.4292
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0073 0.0598 0.0828
Plasmodium falciparum glutathione reductase 0.0174 0.1797 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0238 0.0328
Echinococcus multilocularis peregrin 0.0065 0.0497 0.0497
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0043 0.0238 0.0328
Trichomonas vaginalis antibiotic synthetase, putative 0.0036 0.0163 0.0166
Schistosoma mansoni tyrosine kinase 0.018 0.187 0.187
Leishmania major dihydrolipoamide dehydrogenase, putative 0.006 0.0446 0.1137
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0124 0.1205 0.2166
Schistosoma mansoni hypothetical protein 0.004 0.02 0.02
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0036 0.0163 0.0166
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.02 0.02
Brugia malayi Matrixin family protein 0.0095 0.0856 0.1263
Echinococcus granulosus survival motor neuron protein 1 0.0263 0.2857 0.2857
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0304 0.3348 0.3348
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0043 0.0238 0.0328
Trichomonas vaginalis CAMK family protein kinase 0.0151 0.1521 0.2232
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0073 0.0598 0.3932
Entamoeba histolytica acyl-CoA synthetase, putative 0.0124 0.1205 0.327
Schistosoma mansoni kinase 0.0155 0.1569 0.1569
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0564 0.1259
Echinococcus multilocularis 0.0056 0.0392 0.0392
Leishmania major 4-coumarate:coa ligase-like protein 0.0124 0.1205 0.3333
Brugia malayi hypothetical protein 0.004 0.02 0.0271
Schistosoma mansoni hypothetical protein 0.0065 0.0497 0.0497
Onchocerca volvulus 0.0134 0.1326 0.2219
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0238 0.0238
Brugia malayi glutathione reductase 0.0174 0.1797 0.2688
Plasmodium falciparum thioredoxin reductase 0.006 0.0446 0.238
Entamoeba histolytica hypothetical protein 0.004 0.02 0.0118
Brugia malayi hypothetical protein 0.0051 0.0332 0.047
Mycobacterium ulcerans hydrolase 0.0115 0.1101 0.1593
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0115 0.1101 0.213
Echinococcus granulosus adam 0.0048 0.0306 0.0306
Trichomonas vaginalis set domain proteins, putative 0.0478 0.5406 0.8142
Brugia malayi Thioredoxin reductase 0.0174 0.1797 0.2688
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0036 0.0163 0.0222
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0163 0.0166
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0417 0.0417
Echinococcus multilocularis lysine specific demethylase 5A 0.0078 0.0658 0.0658
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.006 0.0446 0.089
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0043 0.0238 0.0328
Loa Loa (eye worm) oxidoreductase 0.0036 0.0163 0.0214
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0093 0.0832 0.1184
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.006 0.0446 0.0597
Trichomonas vaginalis glutathione reductase, putative 0.006 0.0446 0.0597
Loa Loa (eye worm) hypothetical protein 0.0093 0.0832 0.1227
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0124 0.1205 0.234
Loa Loa (eye worm) hypothetical protein 0.0043 0.0238 0.0328
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0043 0.0238 0.0238
Leishmania major hypothetical protein, conserved 0.0237 0.2543 0.7208
Trichomonas vaginalis CAMK family protein kinase 0.0304 0.3348 0.5012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0564 0.1259
Loa Loa (eye worm) TK/EGFR protein kinase 0.018 0.187 0.2799
Echinococcus multilocularis geminin 0.0171 0.1765 0.1765
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0043 0.0238 0.0238
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0564 0.1549
Onchocerca volvulus Alhambra homolog 0.0065 0.0497 0.0637
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0459 0.0459
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0451 0.065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0043 0.0238 0.0328
Giardia lamblia Kinase, PLK 0.0304 0.3348 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0441 0.4972 1
Schistosoma mansoni tar DNA-binding protein 0.0134 0.132 0.132
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.006 0.0446 0.1191
Loa Loa (eye worm) jmjC domain-containing protein 0.0133 0.1313 0.1955
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0397 0.4445 0.893
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0163 0.0214
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0163 0.0222
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0043 0.0238 0.0238
Mycobacterium ulcerans hypothetical protein 0.0124 0.1205 0.1751
Schistosoma mansoni jumonji/arid domain-containing protein 0.0082 0.0699 0.0699
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0441 0.4972 1
Schistosoma mansoni survival motor neuron protein 0.0054 0.0368 0.0368
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0211 0.2241 0.2241
Entamoeba histolytica serine/threonine protein kinase, putative 0.0304 0.3348 1
Plasmodium vivax acetyl-CoA synthetase, putative 0.0036 0.0163 0.0781
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.006 0.0446 0.1191
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.006 0.0446 0.1191
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0043 0.0238 0.0328
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0238 0.0238
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0332 0.1736
Echinococcus granulosus adam 17 protease 0.0028 0.006 0.006
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0043 0.0238 0.0238
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0344 0.3823 0.3823
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0564 0.1549
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0043 0.0238 0.0238
Loa Loa (eye worm) steroid hormone receptor 0.0043 0.0238 0.0328
Leishmania major cathepsin L-like protease 0.007 0.0564 0.1478
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0332 0.0845
Echinococcus granulosus cpg binding protein 0.0064 0.0492 0.0492
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0459 0.0459
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0043 0.0238 0.0328
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0115 0.1101 0.1634
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.006 0.0446 0.0798
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0073 0.0598 0.1301
Schistosoma mansoni hypothetical protein 0.0034 0.0139 0.0139
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0124 0.1205 0.1751
Loa Loa (eye worm) disintegrin family protein 0.0074 0.0612 0.0894
Loa Loa (eye worm) hypothetical protein 0.0093 0.0832 0.1227
Echinococcus granulosus ecdysone induced protein 78C 0.0043 0.0238 0.0238
Trypanosoma cruzi hypothetical protein, conserved 0.0237 0.2543 0.7555
Brugia malayi ecdysteroid receptor 0.0043 0.0238 0.0328
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0304 0.3348 0.5036
Onchocerca volvulus 0.0043 0.0238 0.0144
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0397 0.4445 0.893
Loa Loa (eye worm) hypothetical protein 0.0068 0.0537 0.078
Echinococcus granulosus epidermal growth factor receptor 0.018 0.187 0.187
Echinococcus multilocularis FTZ F1 alpha 0.0043 0.0238 0.0238
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.006 0.0446 0.0446
Loa Loa (eye worm) hypothetical protein 0.0043 0.0238 0.0328
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0043 0.0238 0.0238
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0163 0.0166
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0043 0.0238 0.0238
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0036 0.0163 0.0331
Entamoeba histolytica hypothetical protein 0.004 0.02 0.0118
Schistosoma mansoni transcription factor LCR-F1 0.004 0.02 0.02
Echinococcus multilocularis L aminoadipate semialdehyde 0.026 0.2816 0.2816
Schistosoma mansoni glutaminase 0.058 0.6627 0.6627
Leishmania major cathepsin L-like protease 0.007 0.0564 0.1478
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0036 0.0163 0.0166
Trypanosoma brucei trypanothione reductase 0.0174 0.1797 0.5131
Leishmania major phosphopantetheinyl transferase-like protein 0.0073 0.0598 0.1576

Activities

Activity type Activity value Assay description Source Reference
AUC (ADMET) = 323 nM/L.hr AUC in mouse at 5 mg/kg, po ChEMBL. 19635666
IC50 (binding) = 26 nM Inhibition of ADAM-10 ChEMBL. 19635666
IC50 (binding) = 27.5 nM Inhibition of HER-2 ChEMBL. 19635666
IC50 (binding) = 1475 nM Inhibition of MMP-2 ChEMBL. 19635666
IC50 (binding) > 5000 nM Inhibition of MMP-1 ChEMBL. 19635666
IC50 (binding) = 5000 nM Inhibition of MMP-3 ChEMBL. 19635666
IC50 (binding) = 5000 nM Inhibition of MMP-9 ChEMBL. 19635666
T1/2 (ADMET) = 0.88 hr Half life in mouse at 5 mg/kg, po ChEMBL. 19635666

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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