Detailed information for compound 1072526

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 244.233 | Formula: C11H7F3OS
  • H donors: 0 H acceptors: 1 LogP: 3.84 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)c1cc2c(s1)c(ccc2)C(F)(F)F
  • InChi: 1S/C11H7F3OS/c1-6(15)9-5-7-3-2-4-8(10(7)16-9)11(12,13)14/h2-5H,1H3
  • InChiKey: UPWYIMWXBIQWNI-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0011 0.0051 0.0051
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0632 1
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0775 0.0775
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.221 0.4224
Loa Loa (eye worm) cytochrome P450 0.001 0.0041 0.0052
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0775 0.2214
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.1287 0.2438
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0168 0.0246
Echinococcus multilocularis Smad4 0.0016 0.013 0.013
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0168 0.0246
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.016 0.016
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0022 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.008 0.0076
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0422 0.1512
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0632 1
Echinococcus multilocularis lamin 0.0027 0.0285 0.0285
Plasmodium vivax peptide deformylase, putative 0.0232 0.3358 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0259 0.0472
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.016 0.1592
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0012 0.0071 0.0071
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0632 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0168 0.0246
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0632 0.1143
Schistosoma mansoni pyruvate kinase 0.0018 0.0161 0.0161
Schistosoma mansoni dishevelled 0.0009 0.0022 0.0022
Giardia lamblia Pyruvate kinase 0.0036 0.0422 0.554
Schistosoma mansoni cpg binding protein 0.0031 0.0347 0.0347
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0632 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.221 0.4216
Giardia lamblia Pyruvate kinase 0.0018 0.0161 0.0012
Trypanosoma cruzi Peptide deformylase 2, putative 0.0089 0.121 0.2261
Brugia malayi hypothetical protein 0.0009 0.0022 0.0003
Echinococcus multilocularis musashi 0.0027 0.0285 0.0285
Echinococcus granulosus pyruvate kinase 0.0018 0.0161 0.0161
Schistosoma mansoni cytochrome P450 0.001 0.0041 0.0041
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0168 0.1737
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0023 0.0023
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.013 0.013
Echinococcus granulosus pyruvate kinase 0.0018 0.0161 0.0161
Echinococcus multilocularis aryl hydrocarbon receptor 0.0012 0.0071 0.0071
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0168 0.0246
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0022 0.0022
Leishmania major cytochrome p450-like protein 0.0019 0.0169 0.0248
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0168 0.0246
Echinococcus multilocularis tumor protein p63 0.0343 0.5007 0.5007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1287 0.1287
Loa Loa (eye worm) hypothetical protein 0.0012 0.0071 0.011
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0051 0.0051
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0541 0.1557
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0168 0.0168
Brugia malayi Cytochrome P450 family protein 0.0048 0.06 0.1117
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0013
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.2116 0.4036
Toxoplasma gondii exonuclease III APE 0.0018 0.016 0.0413
Echinococcus multilocularis pyruvate kinase 0.0018 0.0161 0.0161
Echinococcus multilocularis 0.001 0.0041 0.0041
Echinococcus multilocularis dna polymerase eta 0.0019 0.0168 0.0168
Leishmania major hypothetical protein, conserved 0.0025 0.0255 0.0413
Onchocerca volvulus 0.0035 0.0413 0.148
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0632 0.1143
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0255 0.0413
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0422 0.0736
Schistosoma mansoni smad1 5 8 and 0.0016 0.013 0.013
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0024 0.024 0.3018
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0168 0.0246
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.016 0.023
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0422 0.0784
Treponema pallidum polypeptide deformylase (def) 0.0232 0.3358 1
Leishmania major protein kinase, putative 0.0013 0.0077 0.007
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0012 0.0071 0.0109
Brugia malayi MH1 domain containing protein 0.0016 0.013 0.021
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0168 0.0168
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0541 0.8383
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0168 0.0384
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0168 0.0246
Echinococcus granulosus dnaJ subfamily B 0.044 0.6461 0.6461
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0168 0.0168
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0077 0.007
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0422 0.1148
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.016 0.0359
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0078 0.0078
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1287 0.1287
Brugia malayi hypothetical protein 0.0016 0.0124 0.0199
Trypanosoma brucei Polypeptide deformylase 1 0.0089 0.121 0.2261
Loa Loa (eye worm) hypothetical protein 0.0025 0.0259 0.0472
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0168 0.0246
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0632 0.1143
Echinococcus granulosus pyruvate kinase 0.0036 0.0422 0.0422
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.016 0.023
Mycobacterium ulcerans peptide deformylase 0.0232 0.3358 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.013 0.0223
Schistosoma mansoni hypothetical protein 0.0049 0.0621 0.0621
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0285 0.0509
Giardia lamblia DINP protein human, muc B family 0.0019 0.0168 0.0173
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0413 0.1122
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0168 0.0384
Onchocerca volvulus 0.0012 0.0071 0.0184
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0347 0.0641
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.024 0.0423
Trypanosoma brucei Peptide deformylase 2 0.0089 0.121 0.2261
Loa Loa (eye worm) Smad1 0.0016 0.013 0.0223
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0422 0.0784
Loa Loa (eye worm) hypoxia-induced factor 1 0.0148 0.2092 0.3998
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0285 0.0521
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.024 0.024
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0621 0.0621
Brugia malayi Smad1 0.0016 0.013 0.021
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.008 0.0076
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0186 0.2664 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0016
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.016 0.0269
Schistosoma mansoni hypothetical protein 0.0049 0.0621 0.0621
Echinococcus multilocularis cpg binding protein 0.0033 0.0373 0.0373
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0168 0.0251
Leishmania major polypeptide deformylase-like protein, putative 0.0089 0.121 0.2261
Schistosoma mansoni hypothetical protein 0.0106 0.1474 0.1474
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.016 0.023
Echinococcus granulosus dna polymerase eta 0.0019 0.0168 0.0168
Echinococcus granulosus Smad4 0.0016 0.013 0.013
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0026 0.0011
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0632 0.1829
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0422 0.1148
Loa Loa (eye worm) hypothetical protein 0.0026 0.0277 0.0507
Toxoplasma gondii cytochrome p450 superfamily protein 0.001 0.0041 0.0057
Loa Loa (eye worm) hypothetical protein 0.0356 0.5213 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.013 0.013
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0775 0.142
Echinococcus granulosus aryl hydrocarbon receptor 0.0012 0.0071 0.0071
Schistosoma mansoni lamin 0.0027 0.0285 0.0285
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.013 0.013
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0232 0.3358 1
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0071 0.0057
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0775 0.0775
Loa Loa (eye worm) hypothetical protein 0.016 0.2277 0.4354
Schistosoma mansoni lamin 0.0027 0.0285 0.0285
Leishmania major pyruvate kinase 0.0036 0.0422 0.0736
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0168 0.0284
Brugia malayi PAS domain containing protein 0.0048 0.0598 0.1113
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0022 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1287 0.1287
Giardia lamblia TCP-1 chaperonin subunit beta 0.0024 0.024 0.1697
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0168 0.0168
Brugia malayi MH1 domain containing protein 0.0016 0.013 0.021
Schistosoma mansoni hypothetical protein 0.001 0.0041 0.0041
Echinococcus granulosus tumor protein p63 0.0343 0.5007 0.5007
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0422 0.0736
Loa Loa (eye worm) hypothetical protein 0.0019 0.0168 0.0297
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0028 0.0028
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0028 0.0028
Brugia malayi N-terminal motif family protein 0.0186 0.2664 0.5091
Leishmania major pyruvate kinase 0.0036 0.0422 0.0736
Trypanosoma brucei protein kinase, putative 0.005 0.0632 0.1143
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0169 0.0248
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0775 0.2258
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0635 0.0635
Schistosoma mansoni ap endonuclease 0.0018 0.016 0.016
Echinococcus granulosus intermediate filament protein 0.0027 0.0285 0.0285
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.016 0.023
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0169 0.0248
Schistosoma mansoni hypothetical protein 0.0049 0.0621 0.0621
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0865 0.0865
Brugia malayi intermediate filament protein 0.0027 0.0285 0.0509
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0621 0.1156
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.2054 0.2054
Echinococcus granulosus pyruvate kinase 0.0018 0.0161 0.0161
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0632 0.1143
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0422 0.0784
Loa Loa (eye worm) acetyltransferase 0.0149 0.2116 0.4044
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0541 0.1192
Schistosoma mansoni smad1 5 8 and 0.0016 0.013 0.013
Plasmodium falciparum T-complex protein 1 subunit beta 0.0024 0.024 0.0251
Echinococcus multilocularis geminin 0.0367 0.5377 0.5377
Trichomonas vaginalis chaperonin, putative 0.0024 0.024 0.3018
Echinococcus multilocularis pyruvate kinase 0.0036 0.0422 0.0422
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0012 0.0071 0.0071
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0168 0.0246
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0168 0.0246
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0168 0.0246
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0168 0.0168
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0168 0.0384
Echinococcus multilocularis pyruvate kinase 0.0018 0.0161 0.0161
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0422 0.1198
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0071 0.0057
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.024 0.024
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0022 0.0016
Loa Loa (eye worm) hypothetical protein 0.0182 0.2608 0.499
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.013 0.013
Echinococcus granulosus dna polymerase kappa 0.0019 0.0168 0.0168
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0632 0.0632
Schistosoma mansoni hypothetical protein 0.0367 0.5377 0.5377
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0815 0.2376
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0621 0.0621
Trypanosoma brucei unspecified product 0.0019 0.0168 0.0246
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0168 0.0246
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0051 0.0051
Echinococcus granulosus lamin 0.0027 0.0285 0.0285
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1287 0.1287
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0169 0.0248
Leishmania major protein kinase, putative 0.0017 0.0137 0.0186
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0161 0.0415
Loa Loa (eye worm) hypothetical protein 0.005 0.0635 0.1195
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0016
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0099 0.0152
Echinococcus multilocularis pyruvate kinase 0.0028 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0155 0.221 0.4224
Loa Loa (eye worm) MH2 domain-containing protein 0.024 0.3473 0.6653
Echinococcus granulosus GPCR family 2 0.0049 0.0621 0.0621
Brugia malayi hypothetical protein 0.0025 0.0255 0.0451
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0487 1
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0413 0.0756
Leishmania major DNA polymerase kappa, putative 0.0019 0.0168 0.0246
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0024 0.024 0.0251
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0168 0.0297
Schistosoma mansoni Smad4 0.0016 0.013 0.013
Leishmania major C-8 sterol isomerase-like protein 0.0356 0.5213 1
Brugia malayi cytochrome P450 0.001 0.0041 0.0039
Loa Loa (eye worm) hypothetical protein 0.0012 0.0071 0.0109
Loa Loa (eye worm) transcription factor SMAD2 0.024 0.3473 0.6653
Echinococcus granulosus lamin dm0 0.0027 0.0285 0.0285
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.024 0.024
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0775 0.2214
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0022 0.0022
Echinococcus granulosus smad 0.0016 0.013 0.013
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0161 0.0002
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0422 0.625
Trypanosoma cruzi Peptide deformylase 2, putative 0.0089 0.121 0.2261
Echinococcus granulosus single minded 2 0.0035 0.0413 0.0413
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0022 0.0022
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0169 0.0299
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0022 0.0022
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0077 0.007
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0022 0.0022
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0621 0.1156
Schistosoma mansoni single-minded 0.0048 0.0598 0.0598
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0011 0.0048 0.0052
Onchocerca volvulus 0.0027 0.0285 0.0993
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0168 0.0284
Brugia malayi MH2 domain containing protein 0.0016 0.013 0.021
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0422 0.0736
Schistosoma mansoni dishevelled 0.0009 0.0022 0.0022
Mycobacterium leprae Possible regulatory protein 0.0012 0.0071 0.009
Leishmania major DNA polymerase eta, putative 0.0019 0.0168 0.0246
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0632 0.0632
Chlamydia trachomatis pyruvate kinase 0.0036 0.0422 0.1068
Brugia malayi hypothetical protein 0.016 0.2277 0.4347
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0168 0.0246
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0255 0.0296
Brugia malayi DIX domain containing protein 0.0009 0.0022 0.0003
Echinococcus multilocularis pyruvate kinase 0.0018 0.0161 0.0161
Echinococcus granulosus geminin 0.0367 0.5377 0.5377
Echinococcus multilocularis lamin dm0 0.0027 0.0285 0.0285
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.024 0.0423
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.06 0.1128
Brugia malayi CXXC zinc finger family protein 0.0031 0.0347 0.0629
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0632 0.0632
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0169 0.0299
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.013 0.013
Schistosoma mansoni smad 0.0016 0.013 0.013
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0169 0.0387
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0099 0.0164
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0168 0.0246
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.1474 0.28
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0632 0.0632
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0022 0.0022
Brugia malayi MH2 domain containing protein 0.024 0.3473 0.6649
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0356 0.5213 1
Trypanosoma brucei unspecified product 0.0013 0.008 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0168 0.0246
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0422 0.1148
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0089 0.121 0.2261
Trypanosoma brucei unspecified product 0.0013 0.008 0.0076
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0089 0.121 0.2261
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0161 0.0002
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0621 0.0621
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.008 0.0076
Brugia malayi MAP kinase sur-1 0.005 0.0632 0.1178
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0022 0.0003
Schistosoma mansoni intermediate filament proteins 0.0027 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0036 0.0422 0.0784
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0016
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0541 0.0541
Schistosoma mansoni hypothetical protein 0.044 0.6461 0.6461
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0632 0.1143
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0259 0.304
Echinococcus multilocularis dnaJ subfamily B 0.044 0.6461 0.6461
Loa Loa (eye worm) hypothetical protein 0.0049 0.0621 0.1168
Onchocerca volvulus 0.005 0.0635 0.232
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0071 0.0057
Brugia malayi Cytochrome P450 family protein 0.0019 0.0169 0.0287
Chlamydia trachomatis peptide deformylase 0.0232 0.3358 1
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0285 0.0521
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0422 0.1512
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0024 0.024 0.2453
Loa Loa (eye worm) T-complex protein 1 0.0024 0.024 0.0435
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0168 0.0384
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0422 0.0772
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0632 1
Echinococcus granulosus pyruvate kinase 0.0036 0.0422 0.0422
Schistosoma mansoni dep domain containing protein 0.0009 0.0022 0.0022
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.024 0.0654
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.024 0.0385
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.024 0.0385
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0356 0.5213 1
Brugia malayi Cytochrome P450 family protein 0.001 0.0041 0.0039
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0255 0.0296
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0232 0.3358 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.221 0.4216
Plasmodium falciparum pyruvate kinase 0.0036 0.0422 0.0818
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0255 0.0413
Trypanosoma brucei C-8 sterol isomerase, putative 0.0356 0.5213 1
Schistosoma mansoni pyruvate kinase 0.0036 0.0422 0.0422
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.013 0.013
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0775 0.2214
Loa Loa (eye worm) hypothetical protein 0.0012 0.0071 0.011
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0077 0.007
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0422 0.625
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0022 0.0003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1287 0.1287
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0255 0.0698
Echinococcus granulosus cpg binding protein 0.0033 0.0373 0.0373
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.016 0.0359
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0775 0.2214
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0775 0.0775
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0413 0.0413
Schistosoma mansoni hypothetical protein 0.0367 0.5377 0.5377
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0022 0.0022
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0168 0.1737
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0422 0.0736
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0255 0.0413
Loa Loa (eye worm) hypothetical protein 0.0027 0.0285 0.0521
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0022 0.0022
Brugia malayi MH2 domain containing protein 0.0016 0.013 0.021
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.2116 0.2116
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.016 0.1592
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0487 0.1022
Schistosoma mansoni ap endonuclease 0.0018 0.016 0.016
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0022 0.0003
Echinococcus granulosus cytochrome P450 2K1 0.001 0.0041 0.0041
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0022 0.0022
Schistosoma mansoni pyruvate kinase 0.0036 0.0422 0.0422
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0255 0.0296
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.016 0.0281
Brugia malayi hypothetical protein 0.0009 0.0022 0.0003
Brugia malayi Cytochrome P450 family protein 0.0019 0.0169 0.0287
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0168 0.0246
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0168 0.0246
Loa Loa (eye worm) hypothetical protein 0.0013 0.0078 0.0124
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.013 0.0223
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0541 0.8383
Brugia malayi hypoxia-induced factor 1 0.0148 0.2092 0.399
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1287 0.1287
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0632 0.0632
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0621 0.1168
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0487 0.6919
Plasmodium falciparum peptide deformylase 0.0232 0.3358 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1287 0.1287
Echinococcus multilocularis smad 0.0016 0.013 0.013
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0621 0.0621
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0077 0.007
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0022 0.0022
Echinococcus multilocularis GPCR, family 2 0.0049 0.0621 0.0621
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0422 0.1512
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0168 0.0246
Schistosoma mansoni cpg binding protein 0.0033 0.0373 0.0373
Loa Loa (eye worm) hypothetical protein 0.0106 0.1474 0.2809
Onchocerca volvulus 0.0027 0.0285 0.0993
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.024 0.024
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.024 0.0385
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0632 0.1143
Loa Loa (eye worm) nuclear factor I 0.0009 0.002 0.0013
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0078 0.0078
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.024 0.024
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0169 0.0299
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0632 0.119
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0541 0.1557
Onchocerca volvulus 0.0031 0.0347 0.123
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0775 0.0775
Loa Loa (eye worm) hypothetical protein 0.0186 0.2664 0.5098
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.1287 0.2448
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0422 0.0818
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.2116 0.2116
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0168 0.0246
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0168 0.0246
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0232 0.3358 1
Schistosoma mansoni hypothetical protein 0.0049 0.0621 0.0621
Toxoplasma gondii hypothetical protein 0.0232 0.3358 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0632 0.1143
Echinococcus multilocularis pyruvate kinase 0.0036 0.0422 0.0422
Loa Loa (eye worm) hypothetical protein 0.0025 0.0255 0.0464
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0022 0.0022
Schistosoma mansoni cpg binding protein 0.0033 0.0373 0.0373
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0422 0.0772
Loa Loa (eye worm) histone methyltransferase 0.001 0.0028 0.0028
Schistosoma mansoni DNA polymerase eta 0.0019 0.0168 0.0168
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0598 0.0598

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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