TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 607.979 | Formula: C28H29Cl3N4O3S
H donors: 0 H acceptors: 3 LogP: 4.91 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: Clc1ccc(cc1C#Cc1ccc(c(c1)Cl)Cl)c1nn(c2c1CN(CC2)S(=O)(=O)C)CCCN1CCOCC1
InChi: 1S/C28H29Cl3N4O3S/c1-39(36,37)34-12-9-27-23(19-34)28(32-35(27)11-2-10-33-13-15-38-16-14-33)22-6-8-24(29)21(18-22)5-3-20-4-7-25(30)26(31)17-20/h4,6-8,17-18H,2,9-16,19H2,1H3
InChiKey: QKJGILGOKUNUOC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin S	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin S	281 aa	226 aa	34.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	cathepsin L	0.0014	0.0018	0.0023
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0033	0.0111	0.1893
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0001	0.0015
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0082	0.1661
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0001	0.0002
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0024	0.0068	0.0017
Chlamydia trachomatis	recombinase RecA	0.0124	0.056	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0001	0.0002
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0189	0.0879	0.1128
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0024	0.0068	0.1129
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0252	0.2867
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0332	0.3774
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0024	0.0068	0.2323
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0068	0.0765
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0033	0.0111	0.2287
Trichomonas vaginalis	alpha-glucosidase, putative	0.0016	0.0026	0.045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0014	0.0018	0.0262
Leishmania major	alpha glucosidase II subunit, putative	0.0042	0.0156	0.2901
Schistosoma mansoni	kinase	0.0053	0.0211	0.027
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0033	0.0111	0.1893
Echinococcus multilocularis	cpg binding protein	0.0035	0.0122	0.0156
Plasmodium vivax	vivapain-2	0.0027	0.0082	0.2828
Brugia malayi	hypothetical protein	0.0157	0.0721	0.8206
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0023	0.0063	0.008
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0156	0.3269
Toxoplasma gondii	cathepsin CPL	0.0027	0.0082	0.1634
Echinococcus multilocularis	cysteine protease	0.0027	0.0082	0.0105
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0033	0.0111	0.2249
Schistosoma mansoni	hypothetical protein	0.0039	0.0143	0.0181
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0018	0.0038	0.0707
Echinococcus granulosus	neutral alpha glucosidase AB	0.0042	0.0156	0.02
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0023	0.0063	0.1236
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.0232	0.2638
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0153	0.3217
Onchocerca volvulus		0.0027	0.0082	0.1121
Trypanosoma cruzi	cysteine protease, putative	0.0014	0.0018	0.0262
Trypanosoma brucei	polo-like protein kinase	0.0105	0.0465	1
Trypanosoma brucei	hypothetical protein, conserved	0.0042	0.0153	0.3217
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0082	0.1661
Trichomonas vaginalis	antibiotic synthetase, putative	0.0024	0.0068	0.1364
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0105	0.0465	0.5289
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0068	0.1129
Toxoplasma gondii	propionate-CoA ligase	0.0024	0.0068	0.1342
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0023	0.0063	0.1236
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0039	0.0429
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0024	0.0068	0.0088
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0082	0.1661
Entamoeba histolytica	cysteine protease, putative	0.0014	0.0018	0.0262
Entamoeba histolytica	hypothetical protein	0.0037	0.0133	0.278
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0024	0.0068	0.1129
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0082	0.1661
Leishmania major	4-coumarate:coa ligase-like protein	0.0082	0.0354	0.7348
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0011	0.0006	0.0000034544
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0058	0.0235	0.0184
Trichomonas vaginalis	alpha-glucosidase, putative	0.0016	0.0026	0.045
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0082	0.1661
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.0232	0.2627
Brugia malayi	Cytochrome P450 family protein	0.0033	0.0111	0.1248
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0042	0.0156	0.3269
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0068	0.1129
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0033	0.0111	0.2287
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0068	0.0017
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0023	0.0063	0.0809
Leishmania major	cytochrome p450-like protein	0.0053	0.0211	0.4131
Loa Loa (eye worm)	cytochrome P450 family protein	0.0053	0.0211	0.2398
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0027	0.0082	0.0934
Brugia malayi	AMP-binding enzyme family protein	0.0082	0.0354	0.4022
Echinococcus granulosus	replication factor c subunit 1	0.0011	0.0006	0.0008
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0082	0.1661
Echinococcus granulosus	dnaJ subfamily B	0.0471	0.2264	0.2907
Schistosoma mansoni	hypothetical protein	0.0018	0.0039	0.0048
Brugia malayi	DKFZp564C0469 protein	0.0011	0.0006	0.0052
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0106	0.0472	0.8414
Leishmania major	cytochrome p450-like protein	0.0033	0.0111	0.1891
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0033	0.0111	0.0059
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0153	0.3217
Entamoeba histolytica	hypothetical protein	0.0037	0.0133	0.278
Onchocerca volvulus		0.0042	0.0153	0.2113
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0106	0.0472	0.8414
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0082	0.1661
Onchocerca volvulus		0.0082	0.0354	0.4901
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0104	0.0458	0.0586
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0001	0.0002
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0033	0.0111	0.1893
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0027	0.0082	0.0105
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0105	0.0465	0.9828
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0039	0.005
Plasmodium vivax	vivapain-1	0.0014	0.0018	0.0447
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0033	0.0111	0.0059
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0014	0.0018	0.0262
Echinococcus granulosus	cytochrome P450 2K1	0.0033	0.0111	0.0142
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0038	0.0707
Trichomonas vaginalis	alpha-glucosidase, putative	0.0016	0.0026	0.045
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0252	0.2867
Echinococcus granulosus	cysteine protease	0.0014	0.0018	0.0023
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0023	0.0063	0.1215
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0033	0.0111	0.0059
Trypanosoma cruzi	polo-like protein kinase, putative	0.0105	0.0465	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0027	0.0082	0.0104
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0153	0.0102
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0033	0.0111	0.1893
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0039	0.0444
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0063	0.1236
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0942	0.4574	0.5871
Plasmodium falciparum	ataxin-2 like protein, putative	0.0048	0.0186	0.6691
Toxoplasma gondii	ABC1 family protein	0.0042	0.0153	0.3164
Echinococcus multilocularis	nibrin	0.0011	0.0006	0.0008
Schistosoma mansoni	aldehyde dehydrogenase	0.0106	0.0472	0.0605
Loa Loa (eye worm)	transcription factor SMAD2	0.0138	0.0625	0.7116
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0014	0.0018	0.0262
Mycobacterium ulcerans	esterase/lipase LipP	0.0042	0.0153	0.2662
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0006	0.0067
Trichomonas vaginalis	alpha-glucosidase, putative	0.0042	0.0156	0.3269
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0033	0.0111	0.0059
Trypanosoma cruzi	PAB1-binding protein , putative	0.0048	0.0186	0.3929
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0024	0.0068	0.1364
Echinococcus multilocularis	cysteine protease	0.0027	0.0082	0.0105
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0038	0.0707
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0017	0.0033	0.0357
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0042	0.0153	0.0102
Brugia malayi	hypothetical protein	0.0011	0.0006	0.0052
Trichomonas vaginalis	CAMK family protein kinase	0.0105	0.0465	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0027	0.0082	0.1661
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0001	0.0002
Loa Loa (eye worm)	CYP4Cod1	0.0053	0.0211	0.2398
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0027	0.0082	0.2828
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0039	0.005
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0354	0.4031
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0153	0.0195
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0151	0.0693	0.0644
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0024	0.0068	0.0779
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0156	0.3269
Leishmania major	trypanothione reductase	0.0066	0.0275	0.5581
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0067	0.028	0.0359
Plasmodium vivax	vivapain-2	0.0027	0.0082	0.2828
Plasmodium vivax	unspecified product	0.0014	0.0018	0.0447
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0106	0.0472	0.0606
Mycobacterium ulcerans	hypothetical protein	0.0042	0.0153	0.2662
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0033	0.0111	0.0059
Schistosoma mansoni	hypothetical protein	0.0018	0.0039	0.0048
Brugia malayi	Papain family cysteine protease containing protein	0.0014	0.0018	0.0189
Trypanosoma cruzi	cysteine peptidase, putative	0.0014	0.0018	0.0262
Trichomonas vaginalis	CAMK family protein kinase	0.0052	0.0205	0.4333
Entamoeba histolytica	cysteine protease, putative	0.0014	0.0018	0.0262
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0033	0.0111	0.2287
Entamoeba histolytica	cysteine protease, putative	0.0014	0.0018	0.0262
Plasmodium falciparum	acyl-CoA synthetase	0.0062	0.0252	0.9131
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0068	0.1129
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0252	0.2867
Schistosoma mansoni	topbp1	0.0011	0.0006	0.0006
Onchocerca volvulus	Cathepsin L homolog	0.0027	0.0082	0.1121
Leishmania major	cathepsin L-like protease	0.0027	0.0082	0.1246
Mycobacterium tuberculosis	Probable lipase LipD	0.0042	0.0153	0.0102
Trypanosoma cruzi	cysteine proteinase, putative	0.0014	0.0018	0.0262
Mycobacterium leprae	Conserved hypothetical protein	0.0033	0.0111	0.0298
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0082	0.1661
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0033	0.0111	0.0059
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0011	0.0006	0.0000034544
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0082	0.0354	0.0304
Mycobacterium tuberculosis	Probable hydrolase	0.0042	0.0153	0.0102
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0033	0.0111	0.1893
Schistosoma mansoni	hypothetical protein	0.0471	0.2264	0.2906
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0068	0.1129
Trichomonas vaginalis	CAMK family protein kinase	0.0105	0.0465	1
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0023	0.0063	0.1023
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0082	0.1661
Entamoeba histolytica	hypothetical protein	0.0037	0.0133	0.278
Trypanosoma cruzi	cysteine proteinase, putative	0.0014	0.0018	0.0262
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0082	0.1661
Entamoeba histolytica	cysteine protease, putative	0.0014	0.0018	0.0262
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0082	0.1661
Trichomonas vaginalis	CAMK family protein kinase	0.0105	0.0465	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0001	0.0002
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0033	0.0111	0.0059
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0027	0.0082	0.2828
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0023	0.0063	0.1236
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0023	0.0063	0.1236
Plasmodium vivax	ataxin-2 like protein, putative	0.0048	0.0186	0.6691
Onchocerca volvulus		0.0018	0.0038	0.0514
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0023	0.0063	0.0809
Loa Loa (eye worm)	ctsf protein	0.0027	0.0082	0.0934
Trypanosoma cruzi	PAB1-binding protein , putative	0.0048	0.0186	0.3929
Trichomonas vaginalis	alpha-glucosidase, putative	0.0016	0.0026	0.045
Echinococcus granulosus	nibrin	0.0011	0.0006	0.0008
Brugia malayi	Pax transcription activation domain interacting protein	0.0011	0.0006	0.0052
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0014	0.0018	0.0021
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0014	0.0018	0.0262
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0042	0.0156	0.3269
Leishmania major	cathepsin L-like protease	0.0027	0.0082	0.1246
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0143	0.1622
Loa Loa (eye worm)	cytochrome P450 family protein	0.0053	0.0211	0.2398
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0082	0.1661
Echinococcus granulosus	cathepsin l1	0.0027	0.0082	0.0105
Schistosoma mansoni	hypothetical protein	0.0018	0.0039	0.0048
Schistosoma mansoni	alpha-glucosidase	0.0163	0.0749	0.096
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0068	0.0017
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0017	0.0033	0.0357
Brugia malayi	serine/threonine-protein kinase plk-2	0.0105	0.0465	0.5282
Trypanosoma cruzi	trypanothione reductase, putative	0.0023	0.0063	0.1236
Mycobacterium leprae	POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE)	0.0024	0.0068	0.0178
Toxoplasma gondii	NADPH-glutathione reductase	0.0023	0.0063	0.1215
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0063	0.1236
Onchocerca volvulus		0.0024	0.0068	0.0933
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0133	0.017
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0082	0.1661
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0023	0.0063	0.1023
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0082	0.0354	0.0304
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0001	0.0002
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0024	0.0068	0.1129
Wolbachia endosymbiont of Brugia malayi	recombinase A	0.0124	0.056	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0027	0.0082	0.0104
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0133	0.0171
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.0232	0.2627
Onchocerca volvulus		0.0109	0.0487	0.6746
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0024	0.0068	0.0088
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0068	0.0017
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0153	0.3217
Echinococcus granulosus	cpg binding protein	0.0035	0.0122	0.0156
Toxoplasma gondii	LsmAD domain-containing protein	0.0048	0.0186	0.3865
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0001	0.0002
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0024	0.0068	0.1342
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0027	0.0082	0.0105
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0001	0.0002
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0001	0.0002
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0023	0.0063	0.2104
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0232	0.2638
Trichomonas vaginalis	esterase, putative	0.0042	0.0153	0.3217
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0063	0.1236
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0001	0.0015
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0001	0.0002
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0024	0.0068	0.1364
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0106	0.0472	1
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0033	0.0111	0.0059
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0082	0.1661
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0151	0.0693	0.1947
Schistosoma mansoni	hypothetical protein	0.0018	0.0039	0.0048
Leishmania major	cathepsin L-like protease	0.0027	0.0082	0.1246
Schistosoma mansoni	microtubule-associated protein tau	0.1597	0.779	1
Entamoeba histolytica	cysteine proteinase 2	0.0014	0.0018	0.0262
Entamoeba histolytica	cysteine protease, putative	0.0014	0.0018	0.0262
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0023	0.0063	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0252	0.2867
Mycobacterium leprae	conserved hypothetical protein	0.0042	0.0153	0.0419
Schistosoma mansoni	serine/threonine protein kinase	0.0105	0.0465	0.0595
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0082	0.1661
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0024	0.0068	0.0017
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0024	0.0068	0.1364
Trichomonas vaginalis	alpha-glucosidase, putative	0.0042	0.0156	0.3269
Leishmania major	hypothetical protein, conserved	0.0048	0.0186	0.3581
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.0153	0.5477
Plasmodium vivax	acyl-CoA synthetase, putative	0.0062	0.0252	0.9131
Plasmodium falciparum	glutathione reductase	0.0066	0.0275	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0016	0.0026	0.0287
Toxoplasma gondii	ATPase, AAA family protein	0.0011	0.0006	0.0000033976
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0082	0.092
Mycobacterium tuberculosis	Probable dehydrogenase	0.0151	0.0693	0.0644
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0033	0.0111	0.1893
Leishmania major	cytochrome p450-like protein	0.0033	0.0111	0.1891
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0033	0.0111	0.0059
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0082	0.1661
Loa Loa (eye worm)	cysteine protease	0.0027	0.0082	0.0934
Brugia malayi	Cytochrome P450 family protein	0.0099	0.0436	0.4958
Schistosoma mansoni	eyes absent homolog	0.0078	0.0332	0.0424
Mycobacterium tuberculosis	Probable esterase LipL	0.0042	0.0153	0.0102
Treponema pallidum	recombinase A	0.0124	0.056	1
Brugia malayi	MH2 domain containing protein	0.0138	0.0625	0.7112
Brugia malayi	glutathione reductase	0.0066	0.0275	0.3123
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0053	0.0211	0.3694
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0033	0.0111	0.0059
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0033	0.0111	0.0059
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0068	0.1129
Entamoeba histolytica	cysteine proteinase, putative	0.0014	0.0018	0.0262
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0024	0.0068	0.0765
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0082	0.1661
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0082	0.0354	0.0988
Echinococcus granulosus	thioredoxin glutathione reductase	0.0067	0.028	0.0359
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0042	0.0156	0.3215
Trypanosoma brucei	glucosidase, putative	0.0042	0.0156	0.3269
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0058	0.0235	0.0184
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0033	0.0111	0.1893
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0027	0.0082	0.0105
Schistosoma mansoni	cytochrome P450	0.0033	0.0111	0.0141
Entamoeba histolytica	cysteine protease, putative	0.0014	0.0018	0.0262
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0151	0.0693	0.0644
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0001	0.0015
Echinococcus granulosus	cathepsin L cysteine protease	0.0014	0.0018	0.0023
Trichomonas vaginalis	alpha-glucosidase, putative	0.0042	0.0156	0.3269
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0082	0.1661
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0042	0.0153	0.0197
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0024	0.0068	0.1129
Trichomonas vaginalis	replication factor C large subunit, putative	0.0011	0.0006	0.0000034544
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0168	0.0775	0.2183
Leishmania major	cathepsin L-like protease	0.0027	0.0082	0.1246
Brugia malayi	hypothetical protein	0.0037	0.0133	0.1506
Trichomonas vaginalis	alpha-glucosidase, putative	0.0016	0.0026	0.045
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0024	0.0068	0.0017
Treponema pallidum	NADH oxidase	0.0023	0.0063	0.1023
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0062	0.0252	0.4438
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0024	0.0068	0.1364
Brugia malayi	hypothetical protein	0.0078	0.0332	0.3765
Onchocerca volvulus		0.0033	0.0112	0.154
Mycobacterium tuberculosis	Probable lipase LipE	0.0042	0.0153	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0006	0.0067
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0001	0.0015
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0042	0.0156	0.3269
Schistosoma mansoni	alpha-glucosidase	0.0163	0.0749	0.096
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0068	0.0017
Leishmania major	cathepsin L-like protease	0.0027	0.0082	0.1246
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0024	0.0068	0.1364
Leishmania major	cathepsin L-like protease	0.0027	0.0082	0.1246
Entamoeba histolytica	cysteine proteinase, putative	0.0014	0.0018	0.0262
Trypanosoma brucei	glycosyl hydrolase-like protein	0.0016	0.0026	0.045
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0252	0.2867
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0038	0.0707
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0023	0.0063	0.2104
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0006	0.0067
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0033	0.0111	0.0059
Trichomonas vaginalis	CAMK family protein kinase	0.0105	0.0465	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0063	0.1236
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0038	0.0422
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0153	0.3217
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0023	0.0063	0.1023
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0033	0.0111	0.1893
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0068	0.0765
Schistosoma mansoni	cpg binding protein	0.0035	0.0122	0.0154
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0024	0.0068	0.1364
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0153	0.1746
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0068	0.0765
Schistosoma mansoni	cpg binding protein	0.0033	0.0112	0.0142
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0023	0.0063	0.1023
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0033	0.0111	0.1893
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0082	0.092
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0104	0.0458	0.0588
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0153	0.1746
Schistosoma mansoni	hypothetical protein	0.0022	0.0056	0.007
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0001	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0721	0.8209
Plasmodium vivax	glutathione reductase, putative	0.0066	0.0275	1
Brugia malayi	CXXC zinc finger family protein	0.0033	0.0112	0.1264
Entamoeba histolytica	cysteine protease, putative	0.0014	0.0018	0.0262
Loa Loa (eye worm)	hypothetical protein	0.002	0.005	0.0565
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0082	0.1661
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0006	0.0067
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0082	0.1661
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0042	0.0153	0.1734
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0016	0.0026	0.045
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0082	0.1661
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0023	0.0063	0.1236
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0082	0.1661
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0039	0.005
Schistosoma mansoni	DNA ligase IV	0.0011	0.0006	0.0006
Onchocerca volvulus	Cathepsin F homolog	0.0027	0.0082	0.1121
Loa Loa (eye worm)	cytochrome P450 family protein	0.0099	0.0436	0.4965
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0082	0.1661
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0168	0.0775	0.0727
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0016	0.0026	0.045
Echinococcus multilocularis	replication factor c subunit 1	0.0011	0.0006	0.0008
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0106	0.0472	0.0606
Trichomonas vaginalis	CAMK family protein kinase	0.0105	0.0465	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0027	0.0082	0.0105
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0082	0.0354	0.6282
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0153	0.1746
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0024	0.0068	0.0017
Echinococcus granulosus	microtubule associated protein 2	0.1597	0.779	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0068	0.1129
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0068	0.0779
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0018	0.0038	0.0422
Entamoeba histolytica	cysteine proteinase 1, putative	0.0014	0.0018	0.0262
Leishmania major	cathepsin L-like protease	0.0027	0.0082	0.1246
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0082	0.1661
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0024	0.0068	0.0779
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0022	0.0056	0.0072
Brugia malayi	beta-lactamase family protein	0.0042	0.0153	0.1734
Schistosoma mansoni	chromosome transmission fidelity factor	0.0011	0.0006	0.0006
Trichomonas vaginalis	CAMK family protein kinase	0.0105	0.0465	1
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0033	0.0111	0.1893
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0023	0.0063	0.0809
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0104	0.0458	0.0586
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0068	0.0779
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0063	0.0258	0.5396
Plasmodium falciparum	thioredoxin reductase	0.0023	0.0063	0.2104
Mycobacterium ulcerans	acyl-CoA synthetase	0.0082	0.0354	0.6282
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0033	0.0112	0.1277
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0024	0.0068	0.0017
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0001	0.0002
Loa Loa (eye worm)	glutathione reductase	0.0066	0.0275	0.3134
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0153	0.0102
Plasmodium vivax	vivapain-3	0.0014	0.0018	0.0447
Brugia malayi	beta-lactamase family protein	0.0042	0.0153	0.1734
Leishmania major	4-coumarate:coa ligase-like protein	0.0082	0.0354	0.7348
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0026	0.0302
Loa Loa (eye worm)	thioredoxin reductase	0.0066	0.0275	0.3134
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0014	0.0018	0.0021
Trichomonas vaginalis	alpha-glucosidase, putative	0.0042	0.0156	0.3269
Loa Loa (eye worm)	cytochrome P450	0.0033	0.0111	0.1261
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0033	0.0111	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0001	0.0015
Loa Loa (eye worm)	oxidoreductase	0.0024	0.0068	0.0779
Trichomonas vaginalis	antibiotic synthetase, putative	0.0024	0.0068	0.1364
Mycobacterium ulcerans	beta-lactamase	0.0042	0.0153	0.2662
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0001	0.0002
Echinococcus granulosus	cathepsin l1	0.0018	0.0038	0.0049
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0265	0.1251	0.1206
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0082	0.0934
Loa Loa (eye worm)	fibroinase	0.0027	0.0082	0.0934
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0105	0.0465	0.6436
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0027	0.0082	0.1661
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0016	0.0026	0.045
Trypanosoma cruzi	polo-like protein kinase, putative	0.0105	0.0465	1
Trichomonas vaginalis	CAMK family protein kinase	0.0052	0.0205	0.4333
Trypanosoma brucei	recA bacterial DNA recombination protein, putative	0.0038	0.0138	0.2873
Entamoeba histolytica	cysteine protease, putative	0.0014	0.0018	0.0262
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0082	0.0354	0.759
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0024	0.0068	0.1129
Entamoeba histolytica	cysteine protease, putative	0.0014	0.0018	0.0262
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0023	0.0063	0.0809
Brugia malayi	hypothetical protein	0.0011	0.0006	0.0052
Mycobacterium tuberculosis	Probable oxidoreductase	0.0168	0.0775	0.0727
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0042	0.0156	0.3269
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0001	0.0015
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0106	0.0472	0.8414
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0016	0.0026	0.045
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0082	0.1661
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.0011	0.0006	0.0000034544
Trypanosoma cruzi	cytochrome P450, putative	0.0053	0.0211	0.4464
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0068	0.0765
Onchocerca volvulus		0.0024	0.0068	0.0933
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0082	0.1661
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0153	0.1746
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0168	0.0775	0.0727
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0038	0.0047
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0189	0.0879	0.1128
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0022	0.0056	0.0072
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.0016	0.0026	0.035
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0082	0.1661
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0033	0.0111	0.1893
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0038	0.0422
Schistosoma mansoni	cpg binding protein	0.0035	0.0122	0.0154
Entamoeba histolytica	hypothetical protein	0.0037	0.0133	0.278
Brugia malayi	topoisomerase	0.0011	0.0006	0.0052
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0082	0.0354	0.6282
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0082	0.1661
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0001	0.0015
Echinococcus multilocularis		0.0033	0.0111	0.0142
Onchocerca volvulus		0.0027	0.0082	0.1121
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0001	0.0015
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0153	0.3217
Onchocerca volvulus	Cathepsin L homolog	0.0027	0.0082	0.1121
Mycobacterium leprae	RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN].	0.0124	0.056	0.1573
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0023	0.0063	0.0698
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0082	0.092
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0082	0.092
Brugia malayi	cytochrome P450	0.0033	0.0111	0.1248
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0082	0.1661
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0082	0.1661
Brugia malayi	Thioredoxin reductase	0.0066	0.0275	0.3123
Brugia malayi	cathepsin L-like precursor	0.0018	0.0038	0.0422
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0014	0.0018	0.0262
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0024	0.0068	0.2323
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0023	0.0063	0.2104
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0033	0.0111	0.1893
Mycobacterium ulcerans	recombinase A	0.0124	0.056	1
Mycobacterium leprae	Probable lipase LipE	0.0042	0.0153	0.0419
Onchocerca volvulus		0.0042	0.0153	0.2113
Entamoeba histolytica	cysteine protease, putative	0.0014	0.0018	0.0262
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0039	0.005
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0105	0.0465	0.0597
Schistosoma mansoni	alpha glucosidase	0.0042	0.0156	0.0198
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0016	0.0026	0.045
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0006	0.0067
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0024	0.0068	0.0941
Trypanosoma cruzi	DNA repair protein, putative	0.0038	0.0138	0.2873
Leishmania major	cysteine peptidase A (CPA)	0.0027	0.0082	0.1246
Plasmodium falciparum	thioredoxin reductase	0.0066	0.0275	1
Trypanosoma cruzi	cytochrome P450, putative	0.0053	0.0211	0.4464
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0153	0.3217
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0023	0.0063	0.1236
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0082	0.1661
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0024	0.0068	0.0765
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0033	0.0111	0.1893
Trichomonas vaginalis	glutathione reductase, putative	0.0023	0.0063	0.1236
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0104	0.0458	0.5205
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0023	0.0063	0.2104
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0082	0.0354	0.0988
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0082	0.1661
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0104	0.0458	0.0588
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0039	0.0429
Loa Loa (eye worm)	beta-lactamase	0.0042	0.0153	0.1746
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0038	0.0436
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0042	0.0156	0.02
Entamoeba histolytica	cysteine proteinase, putative	0.0014	0.0018	0.0262
Brugia malayi	Papain family cysteine protease containing protein	0.0027	0.0082	0.092
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0016	0.0026	0.045
Brugia malayi	Cytochrome P450 family protein	0.0053	0.0211	0.2386
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0082	0.1661
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0001	0.0015
Leishmania major	4-coumarate:coa ligase-like protein	0.0082	0.0354	0.7348
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0153	0.1746
Leishmania major	acetyl-CoA synthetase, putative	0.0024	0.0068	0.0941
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0033	0.0111	0.0059
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0066	0.0275	0.0225
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0106	0.0472	0.0423
Brugia malayi	Papain family cysteine protease containing protein	0.0014	0.0018	0.0189
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0042	0.0153	0.0102
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0001	0.0002
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0151	0.0693	0.0644
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0082	0.1661
Onchocerca volvulus		0.0027	0.0082	0.1121
Mycobacterium ulcerans	acyl-CoA synthetase	0.0082	0.0354	0.6282
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0033	0.0111	0.1893
Onchocerca volvulus		0.0024	0.0068	0.0933
Onchocerca volvulus		0.0042	0.0153	0.2113
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0001	0.0015
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0001	0.0015
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0058	0.0235	0.0184
Leishmania major	acetyl-CoA synthetase, putative	0.0024	0.0068	0.0941
Echinococcus granulosus	lysosomal alpha glucosidase	0.0189	0.0879	0.1128
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0354	0.4031
Echinococcus multilocularis	cathepsin L cysteine protease	0.0027	0.0082	0.0105
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0063	0.1236
Brugia malayi	hypothetical protein	0.0048	0.0186	0.2107
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0033	0.0111	0.0059
Toxoplasma gondii	aldehyde dehydrogenase	0.0106	0.0472	1
Trypanosoma brucei	cytochrome P450, putative	0.0053	0.0211	0.4464
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0042	0.0156	0.1774
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0001	0.0002
Echinococcus multilocularis	dnaJ subfamily B	0.0471	0.2264	0.2907
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0068	0.1129
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0001	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0001	0.0015
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0033	0.0111	0.0059
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0153	0.0195
Brugia malayi	AMP-binding enzyme family protein	0.0082	0.0354	0.4022
Brugia malayi	Cytochrome P450 family protein	0.0053	0.0211	0.2386
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0063	0.1236
Leishmania major	hypothetical protein, conserved	0.0042	0.0153	0.2847
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0082	0.1661
Trichomonas vaginalis	mercuric reductase, putative	0.0023	0.0063	0.1236
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0082	0.0354	0.759
Mycobacterium leprae	putative cytochrome p450	0.0033	0.0111	0.0298
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0001	0.0002
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0023	0.0063	0.1023
Onchocerca volvulus		0.0027	0.0082	0.1121
Giardia lamblia	Kinase, PLK	0.0105	0.0465	1
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0033	0.0111	0.1893
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0104	0.0458	0.0586
Onchocerca volvulus		0.0027	0.0082	0.1121
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0039	0.005
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0001	0.0002
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0024	0.0068	0.1129
Echinococcus multilocularis	cathepsin L	0.0014	0.0018	0.0023
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0033	0.0111	0.0059
Plasmodium falciparum	glutathione reductase	0.0023	0.0063	0.2104
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0082	0.1661
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0027	0.0082	0.0934
Trypanosoma cruzi	trypanothione reductase, putative	0.0066	0.0275	0.5873
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0001	0.0015
Entamoeba histolytica	cysteine protease, putative	0.0014	0.0018	0.0262
Echinococcus multilocularis	cathepsin L cysteine protease	0.0027	0.0082	0.0105
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0082	0.1661
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0014	0.0018	0.0021
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0153	0.0102
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0033	0.0111	0.1893
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0082	0.0354	0.6282
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0042	0.0153	0.0102
Onchocerca volvulus		0.0027	0.0082	0.1121
Onchocerca volvulus		0.0024	0.0068	0.0933
Leishmania major	cathepsin L-like protease	0.0027	0.0082	0.1246
Schistosoma mansoni	aldehyde dehydrogenase	0.0106	0.0472	0.0605
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0105	0.0465	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0354	0.4031
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0033	0.0111	0.0059
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0033	0.0111	0.2287
Brugia malayi	AMP-binding enzyme family protein	0.0082	0.0354	0.4022
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0082	0.1661
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0023	0.0063	0.0079
Echinococcus multilocularis	microtubule associated protein 2	0.1597	0.779	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0042	0.0153	0.1746
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0023	0.0063	0.008
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0023	0.0063	0.1236
Mycobacterium ulcerans	lipase LipD	0.0042	0.0153	0.2662
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0082	0.0354	0.6282
Entamoeba histolytica	cysteine proteinase, putative	0.0014	0.0018	0.0262
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0082	0.092
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0082	0.1661
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0153	0.1746
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0033	0.0111	0.1891
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0038	0.0436
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0033	0.0111	0.0059
Trichomonas vaginalis	CAMK family protein kinase	0.0105	0.0465	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0082	0.0354	0.6282
Mycobacterium ulcerans	hypothetical protein	0.0082	0.0354	0.6282
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0062	0.0252	0.0201
Entamoeba histolytica	cysteine protease, putative	0.0014	0.0018	0.0262
Brugia malayi	beta-lactamase	0.0042	0.0153	0.1734
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0068	0.1129
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0039	0.0444
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0001	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0186	0.2119
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0024	0.0068	0.1364
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0024	0.0068	0.1129
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0006	0.0067
Entamoeba histolytica	acyl-coA synthetase, putative	0.0082	0.0354	0.759
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0105	0.0465	1
Mycobacterium leprae	Conserved hypothetical protein	0.073	0.3532	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0104	0.0458	0.5212
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0042	0.0156	0.3269
Echinococcus granulosus	beta LACTamase domain containing family member	0.0042	0.0153	0.0197
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0189	0.0879	1
Schistosoma mansoni	acetyl-CoA synthetase	0.0024	0.0068	0.0086
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0189	0.0879	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0048	0.0186	0.3929
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0104	0.0458	0.0588
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	0.0024	0.0068	0.0178
Plasmodium falciparum	ataxin-2 like protein, putative	0.0048	0.0186	0.6691
Onchocerca volvulus		0.0157	0.0721	1
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0023	0.0063	0.1023
Schistosoma mansoni	hypothetical protein	0.0037	0.0133	0.017
Brugia malayi	hypothetical protein	0.0031	0.0102	0.1152
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0014	0.0018	0.0447
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0082	0.092
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0038	0.0436
Trypanosoma cruzi	DNA repair protein, putative	0.0038	0.0138	0.2873
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0082	0.1661
Mycobacterium tuberculosis	Probable replicative DNA helicase DnaB	0.1923	0.9389	0.9386
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0153	0.3217
Trypanosoma brucei	trypanothione reductase	0.0066	0.0275	0.5873
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0033	0.0111	0.1893
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0133	0.0171
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0058	0.0235	0.0184
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0033	0.0111	0.1893
Schistosoma mansoni	hypothetical protein	0.0033	0.0111	0.0141
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0042	0.0153	0.2662
Onchocerca volvulus		0.0027	0.0082	0.1121
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0143	0.161
Onchocerca volvulus		0.0011	0.0006	0.0063
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0001	0.0015
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0033	0.0111	0.1893
Mycobacterium tuberculosis	Probable reductase	0.0151	0.0693	0.0644
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0068	0.1129
Mycobacterium leprae	POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0068	0.0178
Plasmodium vivax	thioredoxin reductase, putative	0.0066	0.0275	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0001	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0332	0.3774
Trypanosoma cruzi	cruzipain precursor, putative	0.0027	0.0082	0.1661
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0104	0.0458	0.0588
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0027	0.0082	0.2828
Schistosoma mansoni	topbp1	0.0011	0.0006	0.0006
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0062	0.0252	0.4438
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0024	0.0068	0.1129
Entamoeba histolytica	cysteine protease, putative	0.0014	0.0018	0.0262
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.007	0.0294	0.0376
Loa Loa (eye worm)	MH2 domain-containing protein	0.0138	0.0625	0.7116
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0024	0.0068	0.0017
Trichomonas vaginalis	alpha-glucosidase, putative	0.0042	0.0156	0.3269
Echinococcus granulosus	GPCR family 2	0.0018	0.0039	0.005
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.0011	0.0006	0.0052
Toxoplasma gondii	thioredoxin reductase	0.0066	0.0275	0.5776
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0024	0.0068	0.0017
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0024	0.0068	0.1342
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0082	0.1661
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0151	0.0693	0.0644
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0033	0.0111	0.0059
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0042	0.0156	0.3269
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0042	0.0156	0.1761
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0033	0.0111	0.1893

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.32 uM	Inhibition of human recombinant cathepsin S expressed in baculovirus by FRET assay	ChEMBL.	19773165

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL572778

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1072925