Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0417 | 0.0345 |
Schistosoma mansoni | Smad4 | 0.0017 | 0.009 | 0.009 |
Echinococcus multilocularis | cpg binding protein | 0.0065 | 0.0648 | 0.0578 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0059 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0417 | 0.0417 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0279 | 0.0206 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0104 | 0.11 | 0.405 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0059 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0243 | 0.271 | 1 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0017 | 0.009 | 0.0016 |
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 0.0689 | 0.2531 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0104 | 0.11 | 0.405 |
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 0.0689 | 0.2531 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.072 | 0.072 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0017 | 0.009 | 0.0016 |
Schistosoma mansoni | smad | 0.0017 | 0.009 | 0.009 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0017 | 0.009 | 0.0316 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0071 | 0.072 | 0.2645 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0059 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0243 | 0.271 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0019 | 0.0118 | 0.0044 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0417 | 0.1525 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0059 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0279 | 0.0279 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0417 | 0.0345 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0279 | 0.1014 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0279 | 0.0279 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0417 | 0.0345 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.2014 | 0.2014 |
Schistosoma mansoni | smad1 5 8 and | 0.0017 | 0.009 | 0.009 |
Echinococcus multilocularis | smad | 0.0017 | 0.009 | 0.0016 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0689 | 0.0689 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.0279 | 0.0206 |
Echinococcus granulosus | cpg binding protein | 0.0065 | 0.0648 | 0.0578 |
Onchocerca volvulus | 0.0061 | 0.0608 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.11 | 0.405 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0017 | 0.009 | 0.0316 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0417 | 0.0417 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0279 | 0.0279 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0059 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0014 | 0.0059 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 0.0689 | 0.2531 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0417 | 0.1525 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0279 | 0.0206 |
Loa Loa (eye worm) | histone methyltransferase | 0.0019 | 0.0118 | 0.0419 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.072 | 0.2645 |
Brugia malayi | Smad1 | 0.0017 | 0.009 | 0.0316 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0279 | 0.0206 |
Schistosoma mansoni | smad1 5 8 and | 0.0017 | 0.009 | 0.009 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0059 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0689 | 0.0689 |
Brugia malayi | MH1 domain containing protein | 0.0017 | 0.009 | 0.0316 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0279 | 0.0206 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0689 | 0.0689 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0689 | 0.0689 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0061 | 0.0608 | 0.223 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.0279 | 0.1014 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.0279 | 0.0206 |
Echinococcus granulosus | smad | 0.0017 | 0.009 | 0.0016 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0104 | 0.11 | 0.405 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.0279 | 0.1014 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0279 | 0.0279 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0019 | 0.0118 | 0.0044 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0059 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0014 | 0.0059 | 0.5 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0015 | 0.0074 | 0.0074 |
Echinococcus multilocularis | Smad4 | 0.0017 | 0.009 | 0.0016 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0017 | 0.009 | 0.009 |
Brugia malayi | MH1 domain containing protein | 0.0017 | 0.009 | 0.0316 |
Schistosoma mansoni | cpg binding protein | 0.0065 | 0.0648 | 0.0648 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0059 | 0.5 |
Trichomonas vaginalis | helicase, putative | 0.0014 | 0.0059 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.0279 | 0.1014 |
Echinococcus granulosus | geminin | 0.0183 | 0.2014 | 0.1954 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.013 | 0.1403 | 0.1403 |
Echinococcus multilocularis | geminin | 0.0183 | 0.2014 | 0.1954 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.2014 | 0.2014 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0116 | 0.1242 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0061 | 0.0608 | 0.0608 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0068 | 0.0689 | 0.2531 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0059 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0017 | 0.009 | 0.0316 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0059 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0059 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0059 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0059 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0059 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0017 | 0.009 | 0.009 |
Schistosoma mansoni | cpg binding protein | 0.0065 | 0.0648 | 0.0648 |
Brugia malayi | RNA binding protein | 0.0068 | 0.0689 | 0.2531 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0059 | 0.5 |
Loa Loa (eye worm) | Smad1 | 0.0017 | 0.009 | 0.0316 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0417 | 0.0417 |
Echinococcus multilocularis | tar DNA binding protein | 0.0068 | 0.0689 | 0.0619 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0417 | 0.0345 |
Brugia malayi | CXXC zinc finger family protein | 0.0061 | 0.0608 | 0.223 |
Brugia malayi | MH2 domain containing protein | 0.0017 | 0.009 | 0.0316 |
Echinococcus granulosus | Smad4 | 0.0017 | 0.009 | 0.0016 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0243 | 0.271 | 1 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0017 | 0.009 | 0.0016 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0019 | 0.0115 | 0.0409 |
Brugia malayi | TAR-binding protein | 0.0068 | 0.0689 | 0.2531 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0017 | 0.009 | 0.0016 |
Echinococcus granulosus | tar DNA binding protein | 0.0068 | 0.0689 | 0.0619 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0689 | 0.0689 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 36 % | Growth inhibition of human A549 cells at 10 uM after 48 hrs by SRB assay | ChEMBL. | 19926172 |
GI (functional) | = 50 % | Growth inhibition of human MCF7 cells at 10 uM after 48 hrs by SRB assay | ChEMBL. | 19926172 |
GI (functional) | = 54 % | Growth inhibition of human Hep2 cells at 10 uM after 48 hrs by SRB assay | ChEMBL. | 19926172 |
GI (functional) | = 71 % | Growth inhibition of human HCT15 cells at 10 uM after 48 hrs by SRB assay | ChEMBL. | 19926172 |
GI (functional) | = 83 % | Growth inhibition of human COLO205 cells at 10 uM after 48 hrs by SRB assay | ChEMBL. | 19926172 |
GI (functional) | = 98 % | Growth inhibition of human IMR32 cells at 10 uM after 48 hrs by SRB assay | ChEMBL. | 19926172 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.