Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.8893 | 1 |
Echinococcus granulosus | laminin | 0.0031 | 0.5124 | 0.5762 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.0331 | 0.0372 |
Brugia malayi | Fibulin-1 precursor | 0.0031 | 0.5124 | 0.5762 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0331 | 0.0372 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.7301 | 0.821 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0031 | 0.5124 | 0.5762 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0013 | 0.0331 | 0.0372 |
Echinococcus multilocularis | fibrillin 1 | 0.0031 | 0.5124 | 0.5762 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0031 | 0.5124 | 0.5124 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.81 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5124 | 0.5762 |
Echinococcus granulosus | Tolloid protein 1 | 0.0031 | 0.5124 | 0.5762 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0031 | 0.5124 | 1 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0031 | 0.5124 | 0.5762 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0031 | 0.5124 | 0.5762 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0331 | 0.0331 |
Schistosoma mansoni | egf-like domain protein | 0.0031 | 0.5124 | 0.5124 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0331 | 0.0331 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5124 | 0.5762 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.0331 | 0.0372 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0031 | 0.5124 | 0.5762 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.0331 | 0.0372 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5124 | 0.5762 |
Echinococcus multilocularis | laminin | 0.0031 | 0.5124 | 0.5762 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0031 | 0.5124 | 0.5762 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5124 | 0.5762 |
Onchocerca volvulus | Arrow homolog | 0.0031 | 0.5124 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.81 | 0.5 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0031 | 0.5124 | 0.5762 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.8893 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.8893 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5124 | 0.5762 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0031 | 0.5124 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.8893 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.0331 | 0.0372 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2658.227848 nM | Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay | ChEMBL. | 21802950 |
Inhibition (binding) | = 79 % | Inhibition of human ERG at 10 uM | ChEMBL. | 19773164 |
Ki (binding) | = 42 nM | Displacement of [3H]N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK293 cells | ChEMBL. | 19773164 |
Ki (binding) | = 42 nM | Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assay | ChEMBL. | 21802950 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.