Detailed information for compound 1073142

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 339.392 | Formula: C18H21N5O2
  • H donors: 1 H acceptors: 3 LogP: 1.95 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cn([C@@H](C2CC2)C)c(=O)c(n1)Nc1cc(C)c(nc1C)OC
  • InChi: 1S/C18H21N5O2/c1-10-7-15(11(2)20-17(10)25-4)22-16-18(24)23(9-14(8-19)21-16)12(3)13-5-6-13/h7,9,12-13H,5-6H2,1-4H3,(H,21,22)/t12-/m1/s1
  • InChiKey: CLRRTXABLKAYGU-GFCCVEGCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Corticotropin releasing factor receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative Get druggable targets OG5_130760 All targets in OG5_130760
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130760 All targets in OG5_130760
Schistosoma japonicum IPR001879,Hormone receptor, extracellular,domain-containing Get druggable targets OG5_130760 All targets in OG5_130760
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Corticotropin releasing factor receptor 1   415 aa 401 aa 30.2 %
Loa Loa (eye worm) pigment dispersing factor receptor c Corticotropin releasing factor receptor 1   415 aa 394 aa 27.7 %
Loa Loa (eye worm) hypothetical protein Corticotropin releasing factor receptor 1   415 aa 359 aa 21.4 %
Onchocerca volvulus Pseudouridine-5 prime-monophosphatase homolog Corticotropin releasing factor receptor 1   415 aa 401 aa 27.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0104 0.0254 0.271
Schistosoma mansoni cpg binding protein 0.0034 0.007 0.0578
Loa Loa (eye worm) hypothetical protein 0.0077 0.0182 0.1926
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0093 0.3169
Schistosoma mansoni hypothetical protein 0.0015 0.0019 0.0156
Trypanosoma brucei unspecified product 0.0014 0.0017 0.008
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0104 0.0254 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0015 0.0019 0.017
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0034 0.0798
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0084 0.9914
Loa Loa (eye worm) hypothetical protein 0.0356 0.0922 1
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0117 0.0966
Mycobacterium tuberculosis Conserved protein 0.0077 0.0182 0.0163
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0189 0.2571
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.0369 0.3055
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0084 0.2295
Brugia malayi Calcitonin receptor-like protein seb-1 0.0171 0.0431 0.4644
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0189 0.2992
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0084 0.2366
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0104
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0076 0.2556
Leishmania major DNA polymerase kappa, putative 0.0021 0.0034 0.0798
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0034 0.0015
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0182 0.699
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0104 0.0254 1
Schistosoma mansoni hypothetical protein 0.0054 0.0122 0.1008
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.023 0.0587 0.161
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0182 0.699
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0019 0.0149
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.0417 0.4494
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0117 0.0098
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0034 0.0015
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0189 0.7247
Mycobacterium ulcerans hypothetical protein 0.0077 0.0182 0.2864
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0076 0.8783
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0138 0.1451
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0084 0.241
Loa Loa (eye worm) hypothetical protein 0.0077 0.0182 0.1926
Brugia malayi Probable ClpP-like protease 0.0079 0.0189 0.2008
Loa Loa (eye worm) hypothetical protein 0.0077 0.0182 0.1926
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0034 0.0798
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0084 0.0699
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0034 0.0281
Loa Loa (eye worm) latrophilin receptor protein 2 0.0054 0.0122 0.127
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0182 0.699
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0019 0.0149
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0254 1
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0076 0.2556
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0005 0.0044
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0254 1
Brugia malayi beta-lactamase family protein 0.0077 0.0182 0.1929
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0054 0.0122 0.1008
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0034 0.0798
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0076 0.0629
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0034 0.0798
Echinococcus granulosus dnaJ subfamily B 0.0463 0.1206 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0106 0.0876
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0034 0.2743
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0034 0.0798
Brugia malayi Cytochrome P450 family protein 0.0015 0.0019 0.0152
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0034 0.0798
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0356 0.0922 1
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0182 0.2864
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0034 0.0798
Loa Loa (eye worm) acetyltransferase 0.0147 0.0369 0.3964
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0076 0.2556
Schistosoma mansoni peptidase Clp (S14 family) 0.0079 0.0189 0.1567
Loa Loa (eye worm) hypothetical protein 0.0077 0.0182 0.1926
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0019 0.017
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0084 0.291
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0182 0.1506
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0084 0.291
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0104 0.0254 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0034 0.0798
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0034 0.0281
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0017 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0034 0.0798
Treponema pallidum recombinase A 0.023 0.0587 1
Schistosoma mansoni alpha-glucosidase 0.0142 0.0356 0.295
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0079 0.0189 0.1567
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0104 0.0254 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.0358 0.2964
Trichomonas vaginalis esterase, putative 0.0077 0.0182 0.699
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0079 0.0189 0.1567
Echinococcus multilocularis 0.0015 0.0019 0.0156
Echinococcus multilocularis dna polymerase eta 0.0021 0.0034 0.0281
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0034 0.0798
Leishmania major cytochrome p450-like protein 0.0015 0.0019 0.017
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0079 0.0651
Mycobacterium ulcerans lipase LipD 0.0077 0.0182 0.2864
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0084 0.0699
Schistosoma mansoni hypothetical protein 0.0178 0.0449 0.3724
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0138 0.1143
Onchocerca volvulus 0.0077 0.0182 0.7682
Onchocerca volvulus 0.0077 0.0182 0.7682
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0034 0.0798
Schistosoma mansoni alpha-glucosidase 0.0142 0.0356 0.295
Leishmania major cytochrome p450-like protein 0.0015 0.0019 0.017
Onchocerca volvulus 0.0096 0.0232 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0127 0.1334
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0182 0.2864
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0093 0.3059
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0019 0.0149
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0051 0.0091
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0084 0.0066
Leishmania major cytochrome p450-like protein 0.0015 0.0019 0.017
Toxoplasma gondii hypothetical protein 0.0027 0.0051 0.1372
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0034 0.0798
Echinococcus granulosus dna polymerase kappa 0.0021 0.0034 0.0281
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0019 0.017
Brugia malayi beta-lactamase 0.0077 0.0182 0.1929
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0076 0.8783
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0182 0.0163
Chlamydia trachomatis recombinase RecA 0.023 0.0587 1
Trypanosoma brucei protein kinase, putative 0.0104 0.0254 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0106 0.0876
Toxoplasma gondii ABC1 family protein 0.0077 0.0182 0.6938
Toxoplasma gondii exonuclease III APE 0.004 0.0084 0.2788
Schistosoma mansoni cpg binding protein 0.0034 0.007 0.0578
Brugia malayi Cytochrome P450 family protein 0.0015 0.0019 0.0152
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0015 0.0019 0.017
Brugia malayi latrophilin 2 splice variant baaae 0.0117 0.0288 0.3084
Echinococcus granulosus geminin 0.0178 0.0449 0.3724
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0019 0.0156
Loa Loa (eye worm) hypothetical protein 0.0054 0.0122 0.127
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0034 0.0281
Entamoeba histolytica hypothetical protein 0.0038 0.0079 0.9166
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0138 0.2094
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0076 0.2427
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0034 0.0798
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.355 0.9391 0.939
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0182 0.0461
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0034 0.0798
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0017 0.008
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0034 0.0312
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0015 0.0108
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0104 0.0254 1
Brugia malayi Cytochrome P450 family protein 0.0056 0.0127 0.1337
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0019 0.017
Echinococcus granulosus cpg binding protein 0.0034 0.007 0.0578
Echinococcus multilocularis GPCR, family 2 0.0054 0.0122 0.1008
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0182 0.0163
Echinococcus granulosus dna polymerase eta 0.0021 0.0034 0.0281
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0034 0.0316
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0189 0.7247
Brugia malayi hypothetical protein 0.0038 0.0079 0.0803
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0106 0.0876
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0034 0.0798
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0084 0.291
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0182 0.1926
Echinococcus multilocularis geminin 0.0178 0.0449 0.3724
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0076 0.2556
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0093 0.3285
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0104 0.0254 1
Schistosoma mansoni cpg binding protein 0.0033 0.0065 0.0537
Loa Loa (eye worm) cytochrome P450 0.0015 0.0019 0.0149
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.0369 0.3055
Entamoeba histolytica hypothetical protein 0.0038 0.0079 0.9166
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0182 0.0163
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0005 0.0044
Schistosoma mansoni hypothetical protein 0.0054 0.0122 0.1008
Brugia malayi MAP kinase sur-1 0.0104 0.0254 0.2713
Schistosoma mansoni ap endonuclease 0.004 0.0084 0.0699
Brugia malayi Latrophilin receptor protein 2 0.0054 0.0122 0.1273
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0079 0.0189 0.208
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0138 0.1143
Loa Loa (eye worm) hypothetical protein 0.0117 0.0288 0.3081
Schistosoma mansoni ap endonuclease 0.004 0.0084 0.0699
Schistosoma mansoni hypothetical protein 0.0054 0.0122 0.1008
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0239 0.0613 0.5078
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0079 0.0651
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0079 0.0189 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0034 0.0281
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0106 0.0876
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0254 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0084 0.291
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0084 1
Brugia malayi CXXC zinc finger family protein 0.0033 0.0065 0.0653
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0117 0.0966
Echinococcus multilocularis dnaJ subfamily B 0.0463 0.1206 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0189 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0106 0.0876
Schistosoma mansoni cytochrome P450 0.0015 0.0019 0.0156
Trypanosoma cruzi DNA repair protein, putative 0.0071 0.0166 0.6332
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0017 0.008
Schistosoma mansoni hypothetical protein 0.0117 0.0288 0.2384
Brugia malayi Cytochrome P450 family protein 0.0015 0.0019 0.0152
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0054 0.0122 0.1008
Entamoeba histolytica hypothetical protein 0.0038 0.0079 0.9166
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0015 0.0019 0.017
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0034 0.0264
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0034 0.0316
Trypanosoma brucei unspecified product 0.0021 0.0034 0.0798
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0182 0.1506
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0071 0.0166 0.6332
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0104 0.0254 1
Echinococcus granulosus mitogen activated protein kinase 0.0104 0.0254 0.2102
Trypanosoma cruzi DNA repair protein, putative 0.0071 0.0166 0.6332
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0182 0.0163
Echinococcus multilocularis mitogen activated protein kinase 0.0104 0.0254 0.2102
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.0417 0.3456
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0138 0.2094
Leishmania major hypothetical protein, conserved 0.0077 0.0182 0.699
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0182 0.0163
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0182 0.699
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0076 0.2556
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0076 0.2556
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0084 0.062
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0093 0.3169
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0034 0.0798
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0254 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0076 0.2556
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0076 0.2556
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0182 0.9474
Echinococcus multilocularis mitogen activated protein kinase 3 0.0104 0.0254 0.2102
Echinococcus granulosus mitogen activated protein kinase 3 0.0104 0.0254 0.2102
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0138 0.5156
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0182 0.699
Loa Loa (eye worm) hypothetical protein 0.0079 0.0189 0.2005
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0093 0.3285
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.0417 0.4492
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0034 0.0798
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.0417 0.3456
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0034 0.0264
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0127 0.1331
Mycobacterium ulcerans beta-lactamase 0.0077 0.0182 0.2864
Schistosoma mansoni hypothetical protein 0.0178 0.0449 0.3724
Loa Loa (eye worm) hypothetical protein 0.0077 0.0182 0.1926
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0182 0.0163
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0106 0.0876
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0034 0.0798
Schistosoma mansoni hypothetical protein 0.0054 0.0122 0.1008
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0084 0.291
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0084 0.241
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0161 0.1338
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0106 0.1099
Mycobacterium tuberculosis Conserved protein 0.0077 0.0182 0.0163
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0189 0.2992
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0084 0.0866
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0076 0.0629
Wolbachia endosymbiont of Brugia malayi recombinase A 0.023 0.0587 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0262 0.0674 0.7295
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0076 0.2556
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0312
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0076 0.2556
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0034 0.0281
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0104 0.0254 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0106 0.0876
Trypanosoma brucei cytochrome P450, putative 0.0015 0.0019 0.017
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0117 0.0098
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0182 0.1929
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0182 0.699
Schistosoma mansoni DNA polymerase eta 0.0021 0.0034 0.0281
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0117 0.0276
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0034 0.0798
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0084 0.0863
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0079 0.0651
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0019 0.017
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0034 0.0798
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.0369 0.3966
Loa Loa (eye worm) beta-lactamase 0.0077 0.0182 0.1926
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0106 0.1095
Brugia malayi beta-lactamase family protein 0.0077 0.0182 0.1929
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0093 0.0773
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0076 0.0774
Schistosoma mansoni hypothetical protein 0.0463 0.1206 1
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0084 0.291
Giardia lamblia Kinase, CMGC MAPK 0.0104 0.0254 1
Leishmania major DNA polymerase eta, putative 0.0021 0.0034 0.0798
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0065 0.065
Trypanosoma brucei unspecified product 0.0014 0.0017 0.008
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0182 0.0163
Onchocerca volvulus 0.0033 0.0065 0.23
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0079 0.0189 0.0482
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0138 0.0119
Brugia malayi follicle stimulating hormone receptor 0.0262 0.0674 0.7296
Mycobacterium ulcerans recombinase A 0.023 0.0587 1
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0034 0.0798
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0182 0.1506
Onchocerca volvulus 0.0077 0.0182 0.7682
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0254 0.2102
Brugia malayi cytochrome P450 0.0015 0.0019 0.0152
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0084 0.2268
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0182 0.1506
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0182 0.699
Schistosoma mansoni hypothetical protein 0.0038 0.0079 0.0651
Mycobacterium tuberculosis Possible penicillin-binding protein 0.049 0.1277 0.126
Mycobacterium leprae Probable lipase LipE 0.0077 0.0182 0.0461
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0151 0.5649
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0034 0.0798
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0171 0.0431 0.4642
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0084 0.1151
Mycobacterium leprae Conserved hypothetical protein 0.1347 0.355 1
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0182 0.699
Mycobacterium tuberculosis Conserved protein 0.0077 0.0182 0.0163
Loa Loa (eye worm) hypothetical protein 0.0077 0.0182 0.1926
Trypanosoma brucei glucosidase, putative 0.0037 0.0076 0.2556
Echinococcus granulosus GPCR family 2 0.0054 0.0122 0.1008
Echinococcus multilocularis cpg binding protein 0.0034 0.007 0.0578
Schistosoma mansoni alpha glucosidase 0.0037 0.0076 0.0629
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0138 0.1143
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0076 0.077
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0076 0.2556
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0076 0.2556
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0054 0.0122 0.1273
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.0417 0.3456
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0239 0.0613 0.5078
Entamoeba histolytica hypothetical protein 0.0038 0.0079 0.9166

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 10 nM Displacement of [125I]Tyr-o-CRF from CRF1 receptor in rat frontal cortex homogenate by binding titration assay ChEMBL. 19954247

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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