Detailed information for compound 1073288

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 395.501 | Formula: C21H29N7O
  • H donors: 1 H acceptors: 3 LogP: 1.32 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@@H]1CN(C[C@H]1c1[nH]c(=O)c2c(n1)n(nc2)C1CCCC1)Cc1cc(nn1C)C
  • InChi: 1S/C21H29N7O/c1-13-10-27(11-16-8-14(2)25-26(16)3)12-18(13)19-23-20-17(21(29)24-19)9-22-28(20)15-6-4-5-7-15/h8-9,13,15,18H,4-7,10-12H2,1-3H3,(H,23,24,29)/t13-,18-/m1/s1
  • InChiKey: LLIYAZFYRUESNK-FZKQIMNGSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphodiesterase 1C, calmodulin-dependent 70kDa Starlite/ChEMBL References
Homo sapiens phosphodiesterase 9A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Neospora caninum hypothetical protein Get druggable targets OG5_130344 All targets in OG5_130344
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128202 All targets in OG5_128202
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Leishmania infantum cAMP phosphodiesterase A Get druggable targets OG5_128202 All targets in OG5_128202
Leishmania donovani phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Plasmodium yoelii asparagine-rich protein Get druggable targets OG5_130344 All targets in OG5_130344
Schistosoma japonicum ko:K06927 endoribonuclease, putative Get druggable targets OG5_130344 All targets in OG5_130344
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_130344 All targets in OG5_130344
Loa Loa (eye worm) PDE1B protein Get druggable targets OG5_128202 All targets in OG5_128202
Schistosoma japonicum ko:K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC3.1.4.17], putative Get druggable targets OG5_130344 All targets in OG5_130344
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative Get druggable targets OG5_128202 All targets in OG5_128202
Schistosoma japonicum High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, putative Get druggable targets OG5_130344 All targets in OG5_130344
Trypanosoma cruzi cAMP phosphodiesterase A, putative Get druggable targets OG5_128202 All targets in OG5_128202
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_130344 All targets in OG5_130344
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128202 All targets in OG5_128202
Plasmodium berghei 3',5'-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_130344 All targets in OG5_130344
Plasmodium yoelii cGMP phosphodiesterase A4, putative Get druggable targets OG5_130344 All targets in OG5_130344
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 Get druggable targets OG5_128202 All targets in OG5_128202
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase Get druggable targets OG5_128202 All targets in OG5_128202
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic Get druggable targets OG5_130344 All targets in OG5_130344
Cryptosporidium parvum cGMP phosphodiesterase A4 Get druggable targets OG5_128202 All targets in OG5_128202
Neospora caninum 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Babesia bovis 3'5'-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_130344 All targets in OG5_130344
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic Get druggable targets OG5_130344 All targets in OG5_130344
Trypanosoma brucei gambiense 3, 5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Cryptosporidium hominis cGMP phosphodiesterase A4 Get druggable targets OG5_128202 All targets in OG5_128202
Plasmodium knowlesi 3',5'-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_130344 All targets in OG5_130344
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase Get druggable targets OG5_130344 All targets in OG5_130344
Leishmania braziliensis cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 Get druggable targets OG5_128202 All targets in OG5_128202
Trypanosoma brucei cAMP phosphodiesterase A, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trypanosoma congolense 3', 5'-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Leishmania mexicana phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128202 All targets in OG5_128202
Trypanosoma cruzi cAMP phosphodiesterase A, putative Get druggable targets OG5_128202 All targets in OG5_128202
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Neospora caninum hypothetical protein Get druggable targets OG5_128202 All targets in OG5_128202
Neospora caninum hypothetical protein Get druggable targets OG5_128202 All targets in OG5_128202
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0154 0.5643 1
Leishmania major DNA polymerase eta, putative 0.002 0.0522 0.1587
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0092 0.3286 0.3536
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0631 0.1118
Echinococcus multilocularis dna polymerase kappa 0.002 0.0522 0.0452
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0522 0.1587
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0522 0.1587
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0538 0.5
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0023 0.0631 0.0695
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0522 0.1587
Echinococcus multilocularis dna polymerase eta 0.002 0.0522 0.0452
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0023 0.0631 0.0115
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0631 0.0115
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0244 0.9078 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0023 0.0631 0.0574
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0631 0.0115
Loa Loa (eye worm) Smad1 0.0009 0.0117 0.0129
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0092 0.3286 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0023 0.0631 0.0695
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0023 0.0631 0.0115
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0538 0.0954
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0631 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0631 0.0115
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0244 0.9078 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0023 0.0631 0.0115
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0023 0.0631 0.0695
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.1055 0.1162
Loa Loa (eye worm) hypothetical protein 0.0023 0.0631 0.0695
Brugia malayi STAT protein, DNA binding domain containing protein 0.0162 0.595 0.6554
Loa Loa (eye worm) transcription factor SMAD2 0.0135 0.4924 0.5423
Schistosoma mansoni Smad4 0.0009 0.0117 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0631 0.0115
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.1055 0.1162
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0631 0.0115
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0538 0.5
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0538 0.3054
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0023 0.0631 0.0574
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.1742 0.1813
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0244 0.9078 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0631 0.1118
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0631 0.0115
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0631 0.1118
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0522 0.1587
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.1762 0.5363
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0631 0.0115
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0023 0.0631 0.192
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0522 0.0575
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0522 0.1587
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0023 0.0631 0.0695
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0023 0.0631 0.0695
Schistosoma mansoni smad1 5 8 and 0.0009 0.0117 0.0129
Echinococcus granulosus dna polymerase kappa 0.002 0.0522 0.0452
Loa Loa (eye worm) hypothetical protein 0.0023 0.0631 0.0695
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0631 0.0115
Brugia malayi Pre-SET motif family protein 0.0034 0.1055 0.1162
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0023 0.0631 0.192
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0631 0.1118
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0538 0.1638
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0154 0.5643 0.6216
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0522 0.0452
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0287 0.0873
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0538 0.1638
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0023 0.0631 0.192
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0522 0.1587
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0023 0.0631 0.0574
Brugia malayi MH2 domain containing protein 0.0135 0.4924 0.5423
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0631 0.0115
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0631 0.0115
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0631 0.1118
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0023 0.0631 0.192
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0522 0.1587
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0631 0.0115
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0631 0.192
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0631 0.1118
Schistosoma mansoni smad 0.0009 0.0117 0.0129
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0092 0.3286 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0023 0.0631 0.0574
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0023 0.0631 0.0695
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0023 0.0631 0.3581
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0287 0.0873
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0092 0.3286 0.5823
Trypanosoma brucei unspecified product 0.0014 0.0287 0.0873
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0631 0.0115
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0023 0.0631 0.1118
Plasmodium falciparum phosphodiesterase gamma, putative 0.0023 0.0631 0.1118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.1742 0.1918
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.1762 0.1836
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.1762 0.1836
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0631 0.0115
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0023 0.0631 0.0115
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0522 0.1587
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0522 0.1587
Plasmodium falciparum phosphodiesterase delta, putative 0.0023 0.0631 0.1118
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0538 0.0018
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0023 0.0631 0.192
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.1762 0.5363
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0631 0.0115
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0522 0.969
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0522 0.1587
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0023 0.0631 0.0115
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0023 0.0631 0.0115
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0023 0.0631 0.0115
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0092 0.3286 0.5823
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.1762 0.5363
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0631 0.1118
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.1742 0.1813
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.1762 0.5363
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0631 0.0115
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0023 0.0631 0.0574
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0023 0.0631 0.0115
Brugia malayi Smad1 0.0009 0.0117 0.0129
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0538 0.0018
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0538 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0631 0.192
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.1762 0.5363
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0023 0.0631 0.0115
Loa Loa (eye worm) PDE1B protein 0.0244 0.9078 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0023 0.0631 0.0115
Leishmania major hypothetical protein, conserved 0.0023 0.0631 0.192
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0023 0.0631 0.1118
Leishmania major cAMP-specific phosphodiesterase, putative 0.0023 0.0631 0.192
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0023 0.0631 0.192
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0538 0.1638
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.1742 0.1813
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0538 0.047
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.1008 0.0994
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0023 0.0631 0.192
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0631 0.0115
Brugia malayi MAP kinase sur-1 0.0052 0.1762 0.1941
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0154 0.5643 0.6166
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0522 0.969
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0631 0.1118
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0631 0.1118
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.1055 0.1162
Trypanosoma brucei unspecified product 0.002 0.0522 0.1587
Loa Loa (eye worm) hypothetical protein 0.0023 0.0631 0.0695
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0631 0.1118
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.1742 0.1918
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0631 0.192
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.1762 0.3123
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0631 0.192
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0522 0.1587
Trypanosoma brucei protein kinase, putative 0.0052 0.1762 0.5363
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0522 0.0575
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0023 0.0631 0.0574
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0092 0.3286 1
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0631 0.192
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0522 0.1587
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0023 0.0631 0.192
Echinococcus granulosus dna polymerase eta 0.002 0.0522 0.0452
Loa Loa (eye worm) hypothetical protein 0.0034 0.1055 0.1162
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0538 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0023 0.0631 0.0574
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0631 0.1118
Loa Loa (eye worm) hypothetical protein 0.0023 0.0631 0.0695
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0522 0.0575
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.1762 0.1941
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0631 0.0115
Giardia lamblia DINP protein human, muc B family 0.002 0.0522 0.296
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0117 0.0129
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0244 0.9078 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0023 0.0631 0.0695
Leishmania major DNA polymerase kappa, putative 0.002 0.0522 0.1587
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0522 0.1587
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0023 0.0631 0.0115
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0538 0.0593
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0092 0.3286 1
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.1762 1
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0631 0.192
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0023 0.0631 0.0574
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0538 0.1638
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0522 0.0452
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0154 0.5643 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.1742 0.1918
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0023 0.0631 0.0115
Schistosoma mansoni ap endonuclease 0.002 0.0538 0.0593
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0631 0.0115
Schistosoma mansoni ap endonuclease 0.002 0.0538 0.0593
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0522 0.0575
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0287 0.0873
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0631 0.192
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0538 0.0593
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.1742 0.1813
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.1055 0.187
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0023 0.0631 0.0695
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0631 0.0115
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0023 0.0631 0.192
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0117 0.0129
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0023 0.0631 0.0574
Giardia lamblia hypothetical protein 0.0023 0.0631 0.3581
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0631 0.0115
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0092 0.3286 0.3536
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0023 0.0631 0.192
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0631 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0522 0.1587
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0538 0.047
Brugia malayi MH1 domain containing protein 0.0009 0.0117 0.0129
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.1762 0.5363
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0023 0.0631 0.0115
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0631 0.0115
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.1055 0.1162
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.1762 0.1836
Loa Loa (eye worm) MH2 domain-containing protein 0.0135 0.4924 0.5423
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.1762 0.1309
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0538 0.1638
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0631 0.1118
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0631 0.0115
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.1762 0.1836
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0023 0.0631 0.0695
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0522 0.1587
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.1055 0.1047
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0023 0.0631 0.0574
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.1742 0.1918
Loa Loa (eye worm) hypothetical protein 0.002 0.0522 0.0575
Brugia malayi Pre-SET motif family protein 0.0235 0.8758 0.9647
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0631 0.0115
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0522 0.0575
Toxoplasma gondii exonuclease III APE 0.002 0.0538 0.0954
Brugia malayi MH2 domain containing protein 0.0009 0.0117 0.0129
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0522 0.1587
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0631 0.192
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0235 0.8758 0.9647
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0522 0.1587
Trypanosoma brucei unspecified product 0.0014 0.0287 0.0873
Leishmania major hypothetical protein, conserved 0.0023 0.0631 0.192
Brugia malayi MH1 domain containing protein 0.0009 0.0117 0.0129
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.1762 0.1309
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0631 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0522 0.1587
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0023 0.0631 0.0115
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0631 0.192
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.1742 0.1918
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0023 0.0631 0.0695
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0117 0.0129
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0023 0.0631 0.0695
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0023 0.0631 0.0695
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0631 0.0115
Plasmodium vivax SET domain protein, putative 0.0034 0.1055 0.3211
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0522 0.1587
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0631 0.0115
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0023 0.0631 0.0115
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.1762 0.1309
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0023 0.0631 0.0695
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.1055 0.1047
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0631 0.0115
Brugia malayi MH2 domain containing protein 0.0009 0.0117 0.0129
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0154 0.5643 0.6166
Schistosoma mansoni smad1 5 8 and 0.0009 0.0117 0.0129
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0023 0.0631 0.0115
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.1762 0.5363
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0631 0.1118
Schistosoma mansoni smad1 5 8 and 0.0009 0.0117 0.0129
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0522 0.1587
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0023 0.0631 0.0695
Plasmodium vivax phosphodiesterase gamma, putative 0.0023 0.0631 0.192
Giardia lamblia Hypothetical protein 0.0023 0.0631 0.3581
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.1762 0.1309
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0631 0.1118
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0092 0.3286 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0023 0.0631 0.0695
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0631 0.1118
Loa Loa (eye worm) STAT protein 0.0162 0.595 0.6554
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0631 0.1118
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.1762 0.1941
Schistosoma mansoni DNA polymerase eta 0.002 0.0522 0.0575
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0023 0.0631 0.0115
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0631 0.192
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.1055 0.1047
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0538 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.71 Inhibition of human recombinant PDE1C expressed in Sf9 cells by SPA ChEMBL. 19919087
IC50 (binding) = 7.95 Inhibition of human recombinant PDE9A expressed in Sf9 cells by SPA ChEMBL. 19919087
IC50 (binding) = 11 nM Inhibition of human recombinant PDE9A expressed in Sf9 cells by SPA ChEMBL. 19919087
IC50 (binding) = 200 nM Inhibition of human recombinant PDE1C expressed in Sf9 cells by SPA ChEMBL. 19919087

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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