Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Homo sapiens | chemokine (C-C motif) receptor 8 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.92 | Displacement of [3H]dofetilide from human recombinant ERG expressed in HEK293 cells by patch clamp method | ChEMBL. | 19954248 |
IC50 (binding) | = 7.15 | Inhibition of wild type human ERG expressed in CHOK1 cells by whole-cell plate-based electrophysiology | ChEMBL. | 19954248 |
IC50 (functional) | = 7.83 | Antagonist activity at human CCR8 | ChEMBL. | 19954248 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.