Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine D1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | 5-hydroxytryptamine receptor, putative | Get druggable targets OG5_132667 | All targets in OG5_132667 |
Schistosoma japonicum | 5-hydroxytryptamine receptor 1, putative | Get druggable targets OG5_132667 | All targets in OG5_132667 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Glycoprotein hormone beta 5 homolog | Dopamine D2 receptor | 444 aa | 476 aa | 24.2 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Dopamine D2 receptor | 444 aa | 429 aa | 31.7 % |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | Dopamine D2 receptor | 444 aa | 487 aa | 23.8 % |
Loa Loa (eye worm) | hypothetical protein | Dopamine D1 receptor | 446 aa | 370 aa | 24.9 % |
Onchocerca volvulus | RB1-inducible coiled-coil protein 1 homolog | Dopamine D2 receptor | 444 aa | 474 aa | 23.4 % |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Dopamine D1 receptor | 446 aa | 373 aa | 25.5 % |
Echinococcus multilocularis | g protein coupled receptor | Dopamine D2 receptor | 444 aa | 465 aa | 21.5 % |
Echinococcus multilocularis | serotonin receptor | Dopamine D2 receptor | 444 aa | 428 aa | 31.3 % |
Schistosoma mansoni | biogenic amine (5HT) receptor | Dopamine D1 receptor | 446 aa | 394 aa | 29.9 % |
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Dopamine D1 receptor | 446 aa | 366 aa | 35.2 % |
Schistosoma mansoni | amine GPCR | Dopamine D2 receptor | 444 aa | 424 aa | 32.1 % |
Onchocerca volvulus | Dopamine D2 receptor | 444 aa | 418 aa | 23.0 % | |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Dopamine D1 receptor | 446 aa | 407 aa | 33.7 % |
Schistosoma mansoni | biogenic amine (dopamine) receptor | Dopamine D2 receptor | 444 aa | 494 aa | 26.3 % |
Schistosoma japonicum | Octopamine receptor, putative | Dopamine D2 receptor | 444 aa | 456 aa | 29.4 % |
Echinococcus granulosus | g protein coupled receptor | Dopamine D2 receptor | 444 aa | 457 aa | 21.0 % |
Schistosoma japonicum | ko:K04207 neuropeptide Y receptor Y5, putative | Dopamine D2 receptor | 444 aa | 386 aa | 19.7 % |
Onchocerca volvulus | Dopamine D1 receptor | 446 aa | 357 aa | 21.0 % | |
Schistosoma mansoni | biogenic amine receptor | Dopamine D2 receptor | 444 aa | 452 aa | 30.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0158 | 0.9028 | 0.9028 |
Echinococcus multilocularis | Smad4 | 0.0009 | 0.0196 | 0.0196 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.0158 | 0.9028 | 0.9028 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.0158 | 0.9028 | 0.9028 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0158 | 0.9028 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.9028 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0158 | 0.9028 | 0.9028 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0009 | 0.0196 | 0.0196 |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.0196 | 0.0217 |
Schistosoma mansoni | hypothetical protein | 0.0158 | 0.9028 | 0.9028 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0196 | 0.0196 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0133 | 0.7515 | 0.8325 |
Schistosoma mansoni | smad | 0.0009 | 0.0196 | 0.0196 |
Brugia malayi | Smad1 | 0.0009 | 0.0196 | 0.0217 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.0158 | 0.9028 | 0.9028 |
Schistosoma mansoni | apoptosis regulator bax | 0.0158 | 0.9028 | 0.9028 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.004 | 0.2045 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0009 | 0.0196 | 0.0217 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0158 | 0.9028 | 1 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0009 | 0.0196 | 0.0196 |
Schistosoma mansoni | Smad4 | 0.0009 | 0.0196 | 0.0196 |
Echinococcus granulosus | Smad4 | 0.0009 | 0.0196 | 0.0196 |
Loa Loa (eye worm) | Smad1 | 0.0009 | 0.0196 | 0.0217 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.015 | 0.8504 | 0.942 |
Loa Loa (eye worm) | acyl-CoA oxidase | 0.0021 | 0.0918 | 0.1016 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0158 | 0.9028 | 0.9028 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0044 | 0.2261 | 0.5 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.015 | 0.8504 | 0.8504 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.015 | 0.8504 | 0.8504 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.0158 | 0.9028 | 0.9028 |
Echinococcus granulosus | smad | 0.0009 | 0.0196 | 0.0196 |
Echinococcus multilocularis | smad | 0.0009 | 0.0196 | 0.0196 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0044 | 0.2261 | 0.2261 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0196 | 0.0196 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0009 | 0.0196 | 0.0196 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.004 | 0.2045 | 0.5 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.004 | 0.2045 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0133 | 0.7515 | 0.8325 |
Brugia malayi | MH2 domain containing protein | 0.0133 | 0.7515 | 0.8325 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0044 | 0.2261 | 0.5 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0009 | 0.0196 | 0.0217 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.0196 | 0.0217 |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.0196 | 0.0217 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0145 | 0.8256 | 0.8256 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0044 | 0.2261 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0044 | 0.2261 | 0.5 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0009 | 0.0196 | 0.0196 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0009 | 0.0196 | 0.0196 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.0196 | 0.0217 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1445 | 0.1601 |
Brugia malayi | Acyl-CoA oxidase family protein | 0.0034 | 0.1698 | 0.1881 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0196 | 0.0196 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0044 | 0.2261 | 1 |
Loa Loa (eye worm) | acetyltransferase | 0.015 | 0.8504 | 0.942 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of DAT in Wistar rat striatal synaptosomes at 100 uM by [3H]dopamine uptake assay | ChEMBL. | 19540762 | |
Ki (binding) | = 5.628 | Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting | ChEMBL. | 19540762 |
Ki (binding) | = 6.014 | Displacement of [3H]raclopride from dopamine D2 receptor in Wistar rat striatal membrane by liquid scintillation counting | ChEMBL. | 19540762 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.