TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 418.474 | Formula: C19H25F3N2O3S
H donors: 1 H acceptors: 3 LogP: 3.43 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCCS(=O)(=O)N1C[C@H]2CC[C@H]1[C@@H](C2)C(=O)Nc1ccc(cc1)C(F)(F)F
InChi: 1S/C19H25F3N2O3S/c1-2-3-10-28(26,27)24-12-13-4-9-17(24)16(11-13)18(25)23-15-7-5-14(6-8-15)19(20,21)22/h5-8,13,16-17H,2-4,9-12H2,1H3,(H,23,25)/t13-,16+,17-/m0/s1
InChiKey: SKLJLRWKHFMQSG-XKQJLSEDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ELOVL fatty acid elongase 6	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	GNS1/SUR4 family domain-containing protein, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania infantum	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania donovani	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Toxoplasma gondii	GNS1/SUR4 family protein	Get druggable targets OG5_127859	All targets in OG5_127859
Plasmodium knowlesi	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Neospora caninum	GNS1/SUR4 domain containing protein, related	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania major	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Cryptosporidium hominis	fatty-acyl elongase	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania mexicana	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Trypanosoma cruzi	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Plasmodium falciparum	fatty acid elongation protein, GNS1/SUR4 family, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania mexicana	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Plasmodium yoelii	unnamed protein product, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Plasmodium berghei	long chain fatty acid elongation enzyme, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania infantum	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Brugia malayi	GNS1/SUR4 family protein	Get druggable targets OG5_127859	All targets in OG5_127859
Plasmodium falciparum	long chain fatty acid elongation enzyme, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Plasmodium vivax	GNS1/SUR4 domain containing protein	Get druggable targets OG5_127859	All targets in OG5_127859
Loa Loa (eye worm)	fatty acid elongation protein 3	Get druggable targets OG5_127859	All targets in OG5_127859
Trypanosoma brucei	Fatty acid elongase	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania braziliensis	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Trypanosoma cruzi	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Trypanosoma congolense	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Loa Loa (eye worm)	GNS1/SUR4 family protein	Get druggable targets OG5_127859	All targets in OG5_127859
Candida albicans	one of three potential fatty acid elongase genes similar to S. cerevisiae FEN1 (YCR034W), SUR4 (YLR372W) and ELO1 (YJL196C ELO1)	Get druggable targets OG5_127859	All targets in OG5_127859
Plasmodium yoelii	30 kDa glycoprotein	Get druggable targets OG5_127859	All targets in OG5_127859
Cryptosporidium parvum	7 pass integral membrane proteinwith FLHWFHH motif shared with fatty-acyl elongase	Get druggable targets OG5_127859	All targets in OG5_127859
Candida albicans	one of three potential fatty acid elongase genes similar to S. cerevisiae FEN1 (YCR034W), SUR4 (YLR372W) and ELO1 (YJL196C ELO1)	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania major	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Brugia malayi	Fatty acid elongation protein 3	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania braziliensis	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Trypanosoma cruzi	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania donovani	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania major	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania mexicana	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Trypanosoma brucei gambiense	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Trypanosoma cruzi	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania donovani	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Toxoplasma gondii	integral membrane protein, GNS1/SUR4 family protein, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania braziliensis	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania infantum	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	Fatty acid elongase	ELOVL fatty acid elongase 6	265 aa	259 aa	34.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	cysteine protease	0.0819	0.4453	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0819	0.4453	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.043	0.2249	0.4934
Entamoeba histolytica	cysteine proteinase, putative	0.043	0.2249	0.4193
Trypanosoma cruzi	cysteine peptidase, putative	0.043	0.2249	0.2176
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0819	0.4453	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0819	0.4453	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0547	0.291	0.6452
Schistosoma mansoni	hypothetical protein	0.0072	0.0221	0.0495
Echinococcus granulosus	cathepsin b	0.0158	0.0706	0.1585
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0158	0.0706	0.1585
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0052	0.0103	0.0022
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0359	0.1843	0.4001
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0158	0.0706	0.1404
Plasmodium vivax	hypothetical protein, conserved	0.0052	0.0103	0.0022
Echinococcus multilocularis	caspase	0.0052	0.0103	0.0231
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.043	0.2249	0.2176
Trypanosoma cruzi	metacaspase, putative	0.0052	0.0103	0.001
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0819	0.4453	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0158	0.0706	0.1385
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0158	0.0706	0.1585
Plasmodium vivax	unspecified product	0.0272	0.1354	0.289
Brugia malayi	Papain family cysteine protease containing protein	0.0158	0.0706	0.1585
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0819	0.4453	1
Leishmania major	cathepsin L-like protease	0.0819	0.4453	0.4401
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0182	0.084	0.1886
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0158	0.0706	0.1404
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0819	0.4453	1
Schistosoma mansoni	cellular tumor antigen P53	0.0057	0.0135	0.0303
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0158	0.0706	0.1385
Entamoeba histolytica	cysteine proteinase, putative	0.0819	0.4453	1
Loa Loa (eye worm)	hypothetical protein	0.0272	0.1354	0.3039
Brugia malayi	GNS1/SUR4 family protein	0.005	0.0094	0.021
Echinococcus multilocularis	cathepsin L cysteine protease	0.0819	0.4453	1
Trypanosoma cruzi	cysteine protease, putative	0.043	0.2249	0.2176
Entamoeba histolytica	cysteine protease, putative	0.0819	0.4453	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0158	0.0706	0.1385
Loa Loa (eye worm)	hypothetical protein	0.0272	0.1354	0.3039
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0819	0.4453	1
Plasmodium vivax	vivapain-1	0.043	0.2249	0.4944
Entamoeba histolytica	cysteine protease, putative	0.0158	0.0706	0.0127
Entamoeba histolytica	cysteine protease, putative	0.0158	0.0706	0.0127
Brugia malayi	cathepsin F-like cysteine proteinase	0.0272	0.1354	0.3039
Trichomonas vaginalis	conserved hypothetical protein	0.0158	0.0706	0.1385
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0359	0.1843	0.4139
Echinococcus granulosus	microtubule associated protein 2	0.08	0.4345	0.9757
Entamoeba histolytica	cysteine protease, putative	0.043	0.2249	0.4193
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0819	0.4453	1
Entamoeba histolytica	cysteine protease, putative	0.0158	0.0706	0.0127
Entamoeba histolytica	cysteine protease, putative	0.0158	0.0706	0.0127
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0819	0.4453	1
Onchocerca volvulus		0.0819	0.4453	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.043	0.2249	0.2176
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0819	0.4453	1
Plasmodium vivax	vivapain-3	0.043	0.2249	0.4944
Loa Loa (eye worm)	ctsf protein	0.0819	0.4453	1
Loa Loa (eye worm)	hypothetical protein	0.0158	0.0706	0.1585
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0819	0.4453	1
Echinococcus granulosus	cathepsin l1	0.0547	0.291	0.6534
Plasmodium falciparum	serine repeat antigen 5	0.0158	0.0706	0.1404
Plasmodium falciparum	serine repeat antigen 3	0.0158	0.0706	0.1404
Brugia malayi	Cathepsin L-like precursor	0.0547	0.291	0.6534
Plasmodium falciparum	serine repeat antigen 1	0.0158	0.0706	0.1404
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0158	0.0706	0.1585
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0158	0.0706	0.1385
Schistosoma mansoni	cathepsin B (C01 family)	0.0158	0.0706	0.1585
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0158	0.0706	0.1585
Schistosoma mansoni	cathepsin F (C01 family)	0.0819	0.4453	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.043	0.2249	0.5051
Echinococcus granulosus	cathepsin L cysteine protease	0.043	0.2249	0.5051
Entamoeba histolytica	cysteine protease, putative	0.043	0.2249	0.4193
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0819	0.4453	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0221	0.0495
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0158	0.0706	0.0618
Trypanosoma cruzi	metacaspase, putative	0.0052	0.0103	0.001
Schistosoma mansoni	cathepsin F (C01 family)	0.0547	0.291	0.6534
Trypanosoma cruzi	major cysteine proteinase, putative	0.0158	0.0706	0.0618
Plasmodium vivax	unspecified product	0.043	0.2249	0.4944
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0158	0.0706	0.1404
Plasmodium vivax	serine-repeat antigen (SERA)	0.0158	0.0706	0.1404
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0819	0.4453	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0158	0.0706	0.1385
Toxoplasma gondii	cathepsin B	0.0158	0.0706	0.1404
Trypanosoma brucei	metacaspase	0.0052	0.0103	0.001
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0158	0.0706	0.1585
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0819	0.4453	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.043	0.2249	0.5051
Loa Loa (eye worm)	hypothetical protein	0.0254	0.125	0.2808
Entamoeba histolytica	cysteine protease, putative	0.0158	0.0706	0.0127
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0272	0.1354	0.3039
Echinococcus granulosus	caspase	0.0052	0.0103	0.0231
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.015	0.0658	0.1477
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0158	0.0706	0.1385
Entamoeba histolytica	cysteine proteinase 2	0.043	0.2249	0.4193
Plasmodium falciparum	cysteine proteinase falcipain 1	0.043	0.2249	0.4944
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0158	0.0706	0.0127
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0819	0.4453	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0158	0.0706	0.1385
Leishmania major	metacaspase, putative	0.0052	0.0103	0.001
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0052	0.0103	0.0022
Trypanosoma cruzi	cruzipain precursor, putative	0.0272	0.1354	0.1272
Plasmodium vivax	serine-repeat antigen (SERA)	0.0158	0.0706	0.1404
Leishmania major	cathepsin L-like protease	0.0819	0.4453	0.4401
Loa Loa (eye worm)	hypothetical protein	0.0158	0.0706	0.1585
Loa Loa (eye worm)	hypothetical protein	0.0819	0.4453	1
Loa Loa (eye worm)	GNS1/SUR4 family protein	0.005	0.0094	0.021
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0819	0.4453	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0158	0.0706	0.1585
Brugia malayi	cathepsin L-like cysteine proteinase	0.0158	0.0706	0.1585
Plasmodium falciparum	serine repeat antigen 4	0.0158	0.0706	0.1404
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.043	0.2249	0.4934
Echinococcus multilocularis	cathepsin L	0.0158	0.0706	0.1585
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0182	0.084	0.1886
Echinococcus granulosus	cysteine protease	0.043	0.2249	0.5051
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0819	0.4453	1
Toxoplasma gondii	cathepsin CPC1	0.0158	0.0706	0.1404
Plasmodium vivax	vivapain-2	0.0819	0.4453	1
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0158	0.0706	0.1404
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0158	0.0706	0.1404
Brugia malayi	cathepsin L precursor	0.0158	0.0706	0.1585
Brugia malayi	Cathepsin L-like precursor	0.0272	0.1354	0.3039
Echinococcus multilocularis	cathepsin L	0.043	0.2249	0.5051
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0158	0.0706	0.1404
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0158	0.0706	0.1404
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0359	0.1843	0.4001
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0158	0.0706	0.1404
Echinococcus granulosus	tumor protein p63	0.0392	0.2031	0.456
Brugia malayi	Cathepsin L-like precursor	0.0819	0.4453	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0106	0.0411	0.0922
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0158	0.0706	0.1385
Trypanosoma cruzi	major cysteine proteinase, putative	0.1137	0.6252	0.6217
Entamoeba histolytica	cysteine protease, putative	0.043	0.2249	0.4193
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0547	0.291	0.6534
Toxoplasma gondii	cathepsin CPC2	0.0158	0.0706	0.1404
Entamoeba histolytica	cysteine proteinase, putative	0.043	0.2249	0.4193
Entamoeba histolytica	cysteine protease, putative	0.043	0.2249	0.4193
Brugia malayi	Cathepsin L-like precursor	0.0819	0.4453	1
Trypanosoma cruzi	cysteine proteinase, putative	0.043	0.2249	0.2176
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0158	0.0706	0.1385
Entamoeba histolytica	cysteine proteinase 1, putative	0.043	0.2249	0.4193
Echinococcus granulosus	cathepsin L	0.043	0.2249	0.5051
Trypanosoma cruzi	metacaspase 5, putative	0.0052	0.0103	0.001
Onchocerca volvulus		0.0819	0.4453	1
Onchocerca volvulus		0.0819	0.4453	1
Trypanosoma cruzi	cysteine proteinase, putative	0.043	0.2249	0.2176
Brugia malayi	Cathepsin L-like precursor	0.0819	0.4453	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0819	0.4453	1
Entamoeba histolytica	cysteine protease, putative	0.0158	0.0706	0.0127
Brugia malayi	Cathepsin L-like precursor	0.0547	0.291	0.6534
Echinococcus multilocularis	cathepsin b	0.0158	0.0706	0.1585
Entamoeba histolytica	cysteine protease, putative	0.043	0.2249	0.4193
Onchocerca volvulus		0.0819	0.4453	1
Entamoeba histolytica	cysteine protease, putative	0.043	0.2249	0.4193
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0158	0.0706	0.1585
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0158	0.0706	0.1385
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.0052	0.0103	0.0231
Schistosoma mansoni	caspase-7 (C14 family)	0.0052	0.0103	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0547	0.291	0.6534
Echinococcus granulosus	cathepsin l1	0.0819	0.4453	1
Schistosoma mansoni	transcription factor LCR-F1	0.015	0.0658	0.1477
Onchocerca volvulus		0.0547	0.291	0.6452
Schistosoma mansoni	cathepsin s	0.0272	0.1354	0.3039
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0819	0.4453	1
Plasmodium falciparum	serine repeat antigen 6	0.0158	0.0706	0.1404
Brugia malayi	Papain family cysteine protease containing protein	0.043	0.2249	0.5051
Brugia malayi	Cathepsin L-like precursor	0.0819	0.4453	1
Echinococcus granulosus	caspase 8	0.0052	0.0103	0.0231
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.015	0.0658	0.1477
Plasmodium falciparum	serine repeat antigen 2	0.0158	0.0706	0.1404
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0158	0.0706	0.1585
Entamoeba histolytica	cysteine protease, putative	0.043	0.2249	0.4193
Leishmania major	cathepsin L-like protease	0.0819	0.4453	0.4401
Loa Loa (eye worm)	hypothetical protein	0.0272	0.1354	0.3039
Onchocerca volvulus	Cathepsin L homolog	0.0819	0.4453	1
Echinococcus multilocularis	cathepsin b	0.0158	0.0706	0.1585
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0819	0.4453	1
Brugia malayi	Papain family cysteine protease containing protein	0.0819	0.4453	1
Brugia malayi	Fatty acid elongation protein 3	0.005	0.0094	0.021
Leishmania major	cysteine peptidase A (CPA)	0.0819	0.4453	0.4401
Loa Loa (eye worm)	hypothetical protein	0.0158	0.0706	0.1585
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0158	0.0706	0.1385
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0819	0.4453	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0272	0.1354	0.3039
Leishmania major	cathepsin L-like protease	0.0819	0.4453	0.4401
Trypanosoma cruzi	metacaspase 5, putative	0.0052	0.0103	0.001
Echinococcus multilocularis	caspase 2	0.0052	0.0103	0.0231
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0819	0.4453	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0158	0.0706	0.1585
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0158	0.0706	0.0618
Onchocerca volvulus		0.0819	0.4453	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.043	0.2249	0.5051
Loa Loa (eye worm)	hypothetical protein	0.0158	0.0706	0.1585
Echinococcus granulosus	caspase 2	0.0052	0.0103	0.0231
Brugia malayi	Cathepsin L-like precursor	0.0819	0.4453	1
Entamoeba histolytica	cysteine proteinase, putative	0.0819	0.4453	1
Trypanosoma brucei	Metacaspase-4	0.0052	0.0103	0.001
Loa Loa (eye worm)	hypothetical protein	0.0547	0.291	0.6534
Plasmodium falciparum	serine repeat antigen 8	0.0158	0.0706	0.1404
Onchocerca volvulus		0.0057	0.0135	0.0074
Onchocerca volvulus		0.0158	0.0706	0.1385
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0819	0.4453	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0158	0.0706	0.1585
Trypanosoma cruzi	metacaspase, putative	0.0052	0.0103	0.001
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0158	0.0706	0.1585
Onchocerca volvulus	Cathepsin L homolog	0.0819	0.4453	1
Entamoeba histolytica	cysteine protease, putative	0.043	0.2249	0.4193
Loa Loa (eye worm)	hypothetical protein	0.0547	0.291	0.6534
Plasmodium vivax	vivapain-2	0.0819	0.4453	1
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0158	0.0706	0.1404
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0819	0.4453	1
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0158	0.0706	0.1404
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0254	0.125	0.2808
Plasmodium vivax	unspecified product	0.0158	0.0706	0.1404
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.0052	0.0103	0.0231
Schistosoma mansoni	hypothetical protein	0.015	0.0658	0.1477
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0158	0.0706	0.1585
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0158	0.0706	0.1404
Giardia lamblia	Cathepsin B precursor	0.0359	0.1843	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0158	0.0706	0.1585
Entamoeba histolytica	hypothetical protein	0.0158	0.0706	0.0127
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0819	0.4453	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0158	0.0706	0.1585
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0103	0.0231
Entamoeba histolytica	cysteine protease, putative	0.043	0.2249	0.4193
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0819	0.4453	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0359	0.1843	0.4139
Brugia malayi	cathepsin L-like precursor	0.0547	0.291	0.6534
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0819	0.4453	1
Schistosoma mansoni	caspase-3 (C14 family)	0.0052	0.0103	0.0231
Plasmodium falciparum	serine repeat antigen 7	0.0158	0.0706	0.1404
Entamoeba histolytica	cysteine proteinase, putative	0.043	0.2249	0.4193
Entamoeba histolytica	cysteine protease, putative	0.043	0.2249	0.4193
Toxoplasma gondii	cathepsin CPL	0.0819	0.4453	1
Onchocerca volvulus		0.0819	0.4453	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0158	0.0706	0.0618
Schistosoma mansoni	cathepsin C	0.0158	0.0706	0.1585
Brugia malayi	cathepsin B-like cysteine proteinase	0.0158	0.0706	0.1585
Trypanosoma cruzi	metacaspase, putative	0.0052	0.0103	0.001
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0158	0.0706	0.0618
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0158	0.0706	0.1385
Plasmodium falciparum	metacaspase-like protein	0.0052	0.0103	0.0022
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0819	0.4453	1
Plasmodium falciparum	metacaspase 1	0.0052	0.0103	0.0022
Onchocerca volvulus		0.0819	0.4453	1
Echinococcus multilocularis	tumor protein p63	0.0392	0.2031	0.456
Onchocerca volvulus	Cathepsin L homolog	0.0158	0.0706	0.1385
Schistosoma mansoni	microtubule-associated protein tau	0.08	0.4345	0.9757
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0103	0.0231
Echinococcus multilocularis	microtubule associated protein 2	0.08	0.4345	0.9757
Brugia malayi	hypothetical protein	0.015	0.0658	0.1477
Echinococcus multilocularis	cysteine protease	0.0819	0.4453	1
Plasmodium vivax	metacaspase 1, putative	0.0052	0.0103	0.0022
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0158	0.0706	0.1404
Leishmania major	cathepsin L-like protease	0.0819	0.4453	0.4401
Trichomonas vaginalis	conserved hypothetical protein	0.0158	0.0706	0.1385
Brugia malayi	Cathepsin L-like precursor	0.0819	0.4453	1
Brugia malayi	Papain family cysteine protease containing protein	0.043	0.2249	0.5051
Trypanosoma brucei	metacaspase MCA2	0.0052	0.0103	0.001
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0106	0.0411	0.0922
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0158	0.0706	0.1585
Trypanosoma cruzi	cysteine peptidase, putative	0.0819	0.4453	0.4401
Schistosoma mansoni	cathepsin F (C01 family)	0.0819	0.4453	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0819	0.4453	1
Entamoeba histolytica	cysteine protease, putative	0.043	0.2249	0.4193
Loa Loa (eye worm)	fibroinase	0.0819	0.4453	1
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0052	0.0103	0.0231
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0819	0.4453	1
Brugia malayi	Papain family cysteine protease containing protein	0.0158	0.0706	0.1585
Echinococcus multilocularis	caspase 8	0.0052	0.0103	0.0231
Entamoeba histolytica	cysteine protease, putative	0.043	0.2249	0.4193
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0819	0.4453	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0272	0.1354	0.1272
Loa Loa (eye worm)	cathepsin B	0.0158	0.0706	0.1585
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0819	0.4453	1
Loa Loa (eye worm)	hypothetical protein	0.0158	0.0706	0.1585
Plasmodium falciparum	serine repeat antigen 9	0.0158	0.0706	0.1404
Brugia malayi	fibroinase precursor	0.0158	0.0706	0.1585
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0158	0.0706	0.1585
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0158	0.0706	0.1585
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0158	0.0706	0.1385
Entamoeba histolytica	cysteine protease, putative	0.043	0.2249	0.4193
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0819	0.4453	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0547	0.291	0.6452
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0359	0.1843	0.4139
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0135	0.0303
Echinococcus granulosus	cathepsin b	0.0158	0.0706	0.1585
Onchocerca volvulus	Cathepsin F homolog	0.0819	0.4453	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0158	0.0706	0.1385
Trypanosoma brucei	metacaspase MCA3	0.0052	0.0103	0.001
Echinococcus multilocularis	cathepsin L cysteine protease	0.0819	0.4453	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0359	0.1843	0.4001
Brugia malayi	Cell death protein 3 precursor	0.0052	0.0103	0.0231
Brugia malayi	cathepsin F-like cysteine proteinase	0.0158	0.0706	0.1585
Brugia malayi	latrophilin 2 splice variant baaae	0.0072	0.0221	0.0495
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.1525	0.8456	0.8442
Entamoeba histolytica	cysteine proteinase, putative	0.043	0.2249	0.4193
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0158	0.0706	0.1585
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0052	0.0103	0.0231
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0158	0.0706	0.0127
Loa Loa (eye worm)	cysteine protease	0.0819	0.4453	1
Echinococcus granulosus	cathepsin L	0.0158	0.0706	0.1585
Schistosoma mansoni	caspase-7 (C14 family)	0.0052	0.0103	0.0231
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0359	0.1843	0.4001
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.043	0.2249	0.2176
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0158	0.0706	0.1404
Loa Loa (eye worm)	fatty acid elongation protein 3	0.005	0.0094	0.021
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0158	0.0706	0.1404
Loa Loa (eye worm)	hypothetical protein	0.0158	0.0706	0.1585
Entamoeba histolytica	cysteine proteinase, putative	0.0547	0.291	0.5933
Loa Loa (eye worm)	hypothetical protein	0.0158	0.0706	0.1585
Brugia malayi	Papain family cysteine protease containing protein	0.0158	0.0706	0.1585
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0052	0.0103	0.0022
Trypanosoma brucei	metacaspase 5, putative	0.0052	0.0103	0.001
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0819	0.4453	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1300 nM	Inhibition of C-terminal V5-epitope-tagged human ELOVL6 expressed in african green monkey COS7 cells	ChEMBL.	19596583

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL573312

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1074288