Detailed information for compound 1074343

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 595.137 | Formula: C33H35ClN8O
  • H donors: 1 H acceptors: 4 LogP: 5.64 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(c1nc(n(c1Cn1ncnc1)c1ccccc1)c1ccccc1)NCCCN1CCN(CC1)c1cccc(c1C)Cl
  • InChi: 1S/C33H35ClN8O/c1-25-28(34)14-8-15-29(25)40-20-18-39(19-21-40)17-9-16-36-33(43)31-30(22-41-24-35-23-37-41)42(27-12-6-3-7-13-27)32(38-31)26-10-4-2-5-11-26/h2-8,10-15,23-24H,9,16-22H2,1H3,(H,36,43)
  • InChiKey: YMAOGAGJBIXOCM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0302 0.0302
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0041 0.0041
Plasmodium falciparum basic transcription factor 3b, putative 0.0041 0.0237 0.597
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0375 0.0375
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.062 0.062
Loa Loa (eye worm) hypothetical protein 0.0265 0.3122 0.5172
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0288 0.0288
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0397 0.0915
Brugia malayi ecdysteroid receptor 0.0046 0.0302 0.0434
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0234 0.0234
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0215 0.2478 0.2478
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0177 0.0293
Schistosoma mansoni steroid hormone receptor ad4bp 0.0046 0.0302 0.0302
Loa Loa (eye worm) solute carrier family 6 member 4 0.0073 0.0654 0.1083
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0013 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0046 0.0302 0.0501
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.0498 0.0498
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0046 0.0302 0.0501
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0046 0.0302 0.0434
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0652 0.8096 1
Onchocerca volvulus Bile acid receptor homolog 0.0046 0.0302 0.0501
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0134 0.1443 0.0682
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0046 0.0302 0.0302
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0046 0.0302 0.0302
Onchocerca volvulus 0.0492 0.6037 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0652 0.8096 1
Echinococcus granulosus ecdysone induced protein 78C 0.0046 0.0302 0.0302
Echinococcus multilocularis transcription factor btf3 0.0041 0.0237 0.0237
Schistosoma mansoni coup transcription factor 0.0046 0.0302 0.0302
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0046 0.0302 0.0434
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0411 0.059
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0375 0.0539
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.0498 0.0498
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.0498 0.0498
Echinococcus multilocularis Protein lozenge 0.0062 0.0509 0.0509
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0288 0.0288
Schistosoma mansoni hypothetical protein 0.0141 0.1529 0.1529
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0375 0.0375
Loa Loa (eye worm) isocitrate dehydrogenase 0.0035 0.0169 0.0281
Toxoplasma gondii thioredoxin reductase 0.0053 0.0397 1
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.062 0.1027
Brugia malayi mbt repeat family protein 0.0053 0.0403 0.0579
Loa Loa (eye worm) hypothetical protein 0.0046 0.0302 0.0501
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0046 0.0302 0.0302
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0046 0.0302 0.0434
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0403 0.0403
Schistosoma mansoni hypothetical protein 0.0038 0.0207 0.0207
Schistosoma mansoni hypothetical protein 0.0329 0.3947 0.3947
Brugia malayi nuclear receptor NHR-88 0.0046 0.0302 0.0434
Giardia lamblia Fructose-bisphosphate aldolase 0.0652 0.8096 0.5
Loa Loa (eye worm) hypothetical protein 0.0073 0.0654 0.1083
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0062 0.0511 0.0511
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0319 0.381 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0046 0.0302 0.0434
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0652 0.8096 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0046 0.0302 0.0302
Echinococcus granulosus FTZ F1 alpha 0.0046 0.0302 0.0302
Schistosoma mansoni retinoic acid receptor RXR 0.0046 0.0302 0.0302
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0403 0.0403
Loa Loa (eye worm) runx1 0.0062 0.0509 0.0843
Loa Loa (eye worm) hypothetical protein 0.0168 0.1868 0.3094
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0024 0.0026 0.0026
Onchocerca volvulus Huntingtin homolog 0.0137 0.1481 0.2453
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0397 0.0625
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0652 0.8096 1
Loa Loa (eye worm) hypothetical protein 0.0492 0.6037 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0234 0.0234
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0073 0.0654 0.0939
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0046 0.0302 0.0434
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.062 0.062
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.0498 0.0498
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0652 0.8096 1
Schistosoma mansoni survival motor neuron protein 0.0054 0.0411 0.0411
Loa Loa (eye worm) steroid hormone receptor 0.0046 0.0302 0.0501
Brugia malayi jmjC domain containing protein 0.007 0.062 0.0891
Toxoplasma gondii NAC domain-containing protein 0.0041 0.0237 0.2972
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0035 0.0169 0.0169
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0234 0.0234
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0169 0.0169
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0046 0.0302 0.0501
Loa Loa (eye worm) glutathione reductase 0.0053 0.0397 0.0658
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0024 0.0026 0.0043
Echinococcus multilocularis muscleblind protein 1 0.0168 0.1868 0.1868
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0319 0.381 1
Onchocerca volvulus 0.0054 0.0411 0.068
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0576 0.0576
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0434 0.0624
Onchocerca volvulus 0.0073 0.0654 0.1083
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0229 0.2657 0.2657
Schistosoma mansoni thyroid hormone receptor 0.0187 0.2115 0.2115
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0046 0.0302 0.0302
Brugia malayi Isocitrate dehydrogenase 0.0035 0.0169 0.0243
Mycobacterium tuberculosis Probable oxidoreductase 0.0134 0.1443 0.3498
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0375 0.0375
Echinococcus multilocularis thyroid hormone receptor alpha 0.0187 0.2115 0.2115
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0403 0.0403
Onchocerca volvulus Huntingtin homolog 0.0137 0.1481 0.2453
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0397 0.0397
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0229 0.2657 0.2657
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0046 0.0302 0.0434
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0652 0.8096 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0397 0.0397
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0024 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0054 0.0411 0.0411
Schistosoma mansoni hypothetical protein 0.0023 0.0013 0.0013
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0229 0.2657 0.3818
Echinococcus multilocularis ecdysone induced protein 78C 0.0046 0.0302 0.0302
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0046 0.0302 0.0434
Loa Loa (eye worm) hypothetical protein 0.0046 0.0302 0.0501
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0403 0.0403
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0652 0.8096 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0121 0.127 0.3022
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0375 0.0621
Trypanosoma cruzi transcription factor btf3, putative 0.0041 0.0237 0.0272
Plasmodium vivax basic transcription factor 3b, putative 0.0041 0.0237 0.597
Loa Loa (eye worm) glutaminase 0.0317 0.379 0.6278
Onchocerca volvulus 0.0169 0.1892 0.3135
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0229 0.2657 1
Trypanosoma brucei trypanothione reductase 0.0053 0.0397 0.0915
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0434 0.0719
Echinococcus granulosus transcription factor Dp 1 0.0133 0.1418 0.1418
Brugia malayi photoreceptor-specific nuclear receptor 0.0046 0.0302 0.0434
Schistosoma mansoni glutaminase 0.0317 0.379 0.379
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.0498 0.0498
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0375 0.0375
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0403 0.0668
Entamoeba histolytica transcription factor BTF3, putative 0.0041 0.0237 0.0004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0302 0.0302
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0403 0.0668
Brugia malayi Bromodomain containing protein 0.0084 0.0796 0.1144
Schistosoma mansoni hypothetical protein 0.0387 0.4682 0.4682
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0068 0.0592 0.0592
Schistosoma mansoni bromodomain containing protein 0.0071 0.0627 0.0627
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0302 0.0434
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0046 0.0302 0.0302
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0302 0.0302
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0341 0.0341
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0251 0.0017
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0229 0.2657 1
Plasmodium vivax glutathione reductase, putative 0.0053 0.0397 1
Schistosoma mansoni lozenge 0.0062 0.0509 0.0509
Schistosoma mansoni lipoxygenase 0.0062 0.0511 0.0511
Loa Loa (eye worm) serotonin transporter b 0.0073 0.0654 0.1083
Schistosoma mansoni RAR-like nuclear receptor 0.0046 0.0302 0.0302
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0046 0.0302 0.0302
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0046 0.0302 0.0434
Brugia malayi nuclear hormone receptor 0.0046 0.0302 0.0434
Loa Loa (eye worm) hypothetical protein 0.0024 0.0026 0.0043
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0026 0.0026
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0229 0.2657 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0141 0.1529 0.1529
Plasmodium falciparum glutathione reductase 0.0053 0.0397 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.033 0.0547
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0121 0.127 0.3022
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0026 0.0037
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0046 0.0302 0.0501
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0434 0.0624
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.0498 0.0716
Brugia malayi Serotonin receptor 0.0564 0.696 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.1892 0.3135
Loa Loa (eye worm) hypothetical protein 0.0046 0.0302 0.0501
Entamoeba histolytica hypothetical protein 0.0041 0.0237 0.0004
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0288 0.0477
Loa Loa (eye worm) hypothetical protein 0.0024 0.0026 0.0043
Brugia malayi hypothetical protein 0.0024 0.0026 0.0037
Schistosoma mansoni transcription factor btf3 0.0041 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0038 0.0207 0.0343
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0134 0.1443 0.3498
Schistosoma mansoni thyroid hormone receptor 0.0187 0.2115 0.2115
Echinococcus multilocularis survival motor neuron protein 1 0.0265 0.3122 0.3122
Echinococcus granulosus lysine specific demethylase 5A 0.007 0.062 0.062
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0134 0.1443 0.3498
Loa Loa (eye worm) hypothetical protein 0.0079 0.0735 0.1217
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0207 0.0297
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0121 0.127 0.3022
Brugia malayi hypothetical protein 0.0024 0.0026 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0046 0.0302 0.0434
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0121 0.127 0.3022
Loa Loa (eye worm) hypothetical protein 0.0046 0.0303 0.0502
Schistosoma mansoni hypothetical protein 0.0387 0.4682 0.4682
Onchocerca volvulus 0.0053 0.0403 0.0668
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0375 0.0375
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0046 0.0302 0.0434
Onchocerca volvulus Protein ultraspiracle homolog 0.0046 0.0302 0.0501
Schistosoma mansoni jumonji domain containing protein 0.0068 0.0592 0.0592
Echinococcus multilocularis geminin 0.0387 0.4682 0.4682
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0403 0.0403
Echinococcus multilocularis serotonin transporter 0.0073 0.0654 0.0654
Echinococcus multilocularis isocitrate dehydrogenase 0.0035 0.0169 0.0169
Echinococcus granulosus transcription factor btf3 0.0041 0.0237 0.0237
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0141 0.1529 0.1529
Loa Loa (eye worm) hypothetical protein 0.0046 0.0302 0.0501
Loa Loa (eye worm) hypothetical protein 0.0024 0.0026 0.0043
Loa Loa (eye worm) glutaminase 2 0.0317 0.379 0.6278
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0046 0.0302 0.0434
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0062 0.0511 0.0511
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0403 0.0403
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0229 0.2657 0.4401
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0046 0.0302 0.0302
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0168 0.1868 0.3094
Loa Loa (eye worm) hypothetical protein 0.0046 0.0302 0.0501
Brugia malayi Steroid receptor seven-up type 2 0.0046 0.0302 0.0434
Echinococcus granulosus geminin 0.0387 0.4682 0.4682
Loa Loa (eye worm) hypothetical protein 0.0024 0.0026 0.0043
Loa Loa (eye worm) hypothetical protein 0.0043 0.0269 0.0445
Plasmodium falciparum thioredoxin reductase 0.0053 0.0397 1
Brugia malayi Thioredoxin reductase 0.0053 0.0397 0.0571
Onchocerca volvulus 0.0046 0.0302 0.0501
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0046 0.0302 0.0302
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0375 0.0375
Schistosoma mansoni sodium/chloride dependent transporter 0.0073 0.0654 0.0654
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0046 0.0302 0.0302
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0046 0.0302 0.0501
Brugia malayi PHD-finger family protein 0.0028 0.0075 0.0107
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0035 0.0169 0.0169
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0229 0.2657 0.3082
Brugia malayi Muscleblind-like protein 0.0168 0.1868 0.2683
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0397 0.0658
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0026 0.0037
Schistosoma mansoni nuclear hormone receptor 0.0046 0.0302 0.0302
Brugia malayi Cytochrome P450 family protein 0.0036 0.0177 0.0254
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0652 0.8096 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0498 0.0825
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0046 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0024 0.0026 0.0043
Brugia malayi beta-NAC-like protein 0.0041 0.0237 0.0341
Loa Loa (eye worm) hypothetical protein 0.0492 0.6037 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0213 0.0352
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0046 0.0302 0.0302
Schistosoma mansoni hypothetical protein 0.004 0.0234 0.0234
Loa Loa (eye worm) MBCTL1 0.0061 0.0498 0.0825
Brugia malayi hypothetical protein 0.0169 0.1892 0.2719
Brugia malayi mbt repeat family protein 0.0053 0.0403 0.0579
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0046 0.0302 0.0434
Echinococcus multilocularis lysine specific demethylase 5A 0.0068 0.0592 0.0592
Loa Loa (eye worm) hypothetical protein 0.0137 0.1481 0.2453
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0234 0.0234
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0068 0.0592 0.0592
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0046 0.0302 0.0302
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0169 0.0169
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0035 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0073 0.0654 0.1083
Trichomonas vaginalis glutaminase, putative 0.0317 0.379 0.452
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0137 0.1481 0.2453
Brugia malayi hypothetical protein 0.004 0.0234 0.0337
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0073 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0046 0.0302 0.0501
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0397 1
Brugia malayi nuclear receptor RXR 0.0024 0.0026 0.0037
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0035 0.0169 0.4267
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0215 0.2478 0.2478
Brugia malayi Bromodomain containing protein 0.0043 0.0268 0.0385
Echinococcus granulosus muscleblind protein 0.0168 0.1868 0.1868
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0046 0.0302 0.0434
Brugia malayi jmjC domain containing protein 0.0068 0.0592 0.0851
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0341 0.0341
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0169 0.0169
Mycobacterium tuberculosis Probable reductase 0.0121 0.127 0.3022
Echinococcus granulosus survival motor neuron protein 1 0.0265 0.3122 0.3122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0046 0.0302 0.0501
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0319 0.381 1
Echinococcus multilocularis transcription factor Dp 1 0.0133 0.1418 0.1418
Echinococcus multilocularis FTZ F1 alpha 0.0046 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0046 0.0302 0.0501
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0652 0.8096 1
Leishmania major trypanothione reductase 0.0053 0.0397 0.0915
Mycobacterium tuberculosis Probable dehydrogenase 0.0121 0.127 0.3022
Brugia malayi hypothetical protein 0.0137 0.1481 0.2127
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0576 0.0576
Loa Loa (eye worm) hypothetical protein 0.0073 0.0654 0.1083
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0652 0.8096 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0288 0.0414
Brugia malayi glutaminase DH11.1 0.0317 0.379 0.5445
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0046 0.0302 0.0302
Brugia malayi hypothetical protein 0.0492 0.6037 0.8674
Brugia malayi hypothetical protein 0.0265 0.3122 0.4486
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0035 0.0169 0.4267
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0046 0.0302 0.0501
Echinococcus granulosus serotonin transporter 0.0073 0.0654 0.0654
Echinococcus multilocularis muscleblind protein 0.0168 0.1868 0.1868
Brugia malayi isocitrate dehydrogenase 0.0035 0.0169 0.0243
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0046 0.0302 0.0501
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0024 0.0026 0.0026
Leishmania major basic transcription factor 3a, putative 0.0041 0.0237 0.0272
Loa Loa (eye worm) hypothetical protein 0.0046 0.0302 0.0501
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0046 0.0302 0.0302
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0229 0.2657 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0434 0.0719
Loa Loa (eye worm) norepinephrine transporter 0.0073 0.0654 0.1083
Brugia malayi glutathione reductase 0.0053 0.0397 0.0571
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0041 0.0041
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0229 0.2657 0.2657
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0375 0.0375
Trypanosoma brucei transcription factor BTF3, putative 0.0041 0.0237 0.0272
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0234 0.0234
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0041 0.0041
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0251 0.0017
Trypanosoma cruzi transcription factor btf3, putative 0.0041 0.0237 0.0272
Brugia malayi steroid hormone receptor 0.0046 0.0302 0.0434
Loa Loa (eye worm) hypothetical protein 0.0053 0.0403 0.0668
Loa Loa (eye worm) ICD-1 protein 0.0041 0.0237 0.0393
Treponema pallidum fructose-bisphosphate aldolase 0.0652 0.8096 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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