Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | activin A receptor, type IB | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | TGF-beta receptor type-1 | Get druggable targets OG5_129709 | All targets in OG5_129709 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | Get druggable targets OG5_129709 | All targets in OG5_129709 |
Echinococcus multilocularis | TGF beta receptor type 1 | Get druggable targets OG5_129709 | All targets in OG5_129709 |
Schistosoma mansoni | protein kinase | Get druggable targets OG5_129709 | All targets in OG5_129709 |
Schistosoma japonicum | ko:K04674 transforming growth factor, beta receptor I, putative | Get druggable targets OG5_129709 | All targets in OG5_129709 |
Brugia malayi | bone morphogenetic protein type 1 receptor | Get druggable targets OG5_129709 | All targets in OG5_129709 |
Echinococcus granulosus | TGF beta receptor type 1 | Get druggable targets OG5_129709 | All targets in OG5_129709 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0191 | 0.4808 | 0.752 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0204 | 0.0318 |
Brugia malayi | hypothetical protein | 0.0074 | 0.1207 | 0.1889 |
Trichomonas vaginalis | esterase, putative | 0.0041 | 0.0204 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0041 | 0.0204 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0204 | 0.0318 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0243 | 0.6393 | 1 |
Schistosoma mansoni | protein kinase | 0.0191 | 0.4816 | 0.4816 |
Brugia malayi | bone morphogenetic protein type 1 receptor | 0.0191 | 0.4808 | 0.752 |
Echinococcus multilocularis | TGF beta receptor type 1 | 0.0191 | 0.4816 | 0.4708 |
Echinococcus granulosus | TGF beta receptor type 1 | 0.0191 | 0.4816 | 0.4708 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0204 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0243 | 0.6393 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0204 | 0.0318 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0204 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0204 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0041 | 0.0204 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1207 | 0.1889 |
Echinococcus multilocularis | activin receptor type | 0.0086 | 0.1604 | 0.1429 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0204 | 0.0318 |
Schistosoma mansoni | protein kinase | 0.0086 | 0.1595 | 0.1595 |
Echinococcus granulosus | TGF-beta receptor type-1 | 0.0191 | 0.4816 | 0.4708 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0243 | 0.6393 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0041 | 0.0204 | 0.0318 |
Echinococcus granulosus | activin receptor type | 0.0086 | 0.1604 | 0.1429 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0204 | 0.0318 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0204 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0204 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0041 | 0.0204 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.0204 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0041 | 0.0204 | 0.0318 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0204 | 0.0204 |
Onchocerca volvulus | 0.0041 | 0.0204 | 0.5 | |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0204 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0041 | 0.0204 | 0.0318 |
Loa Loa (eye worm) | TKL/STKR/TYPE2 protein kinase | 0.0074 | 0.1216 | 0.1902 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0482 | 0.0754 |
Mycobacterium ulcerans | lipase LipD | 0.0041 | 0.0204 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0074 | 0.1216 | 0.1902 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0204 | 0.5 |
Brugia malayi | protein C17H12.11 | 0.0074 | 0.1207 | 0.1889 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0204 | 0.0318 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0074 | 0.1216 | 0.1902 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.026 | 0.6915 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0482 | 0.0754 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0204 | 0.0318 |
Brugia malayi | beta-lactamase | 0.0041 | 0.0204 | 0.0318 |
Mycobacterium leprae | Probable lipase LipE | 0.0041 | 0.0204 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0204 | 0.0318 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0041 | 0.0204 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0204 | 0.0204 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0041 | 0.0204 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0041 | 0.0204 | 0.5 |
Onchocerca volvulus | 0.0041 | 0.0204 | 0.5 | |
Onchocerca volvulus | 0.0041 | 0.0204 | 0.5 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0482 | 0.0754 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0041 | 0.0204 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase receptor R3 | 0.0086 | 0.1604 | 0.1429 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0482 | 0.0754 |
Toxoplasma gondii | ABC1 family protein | 0.0041 | 0.0204 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6 nM | Inhibition of 6His-tagged human ALK5 expressed in baculovirus-infected SF21 cells after 30 mins by fluorescence polarization assay | ChEMBL. | 19736928 |
IC50 (binding) | = 62 nM | Inhibition of ALK5 in human MDA-MB-468 cells assessed as inhibition of nuclear translocation of GFP-2/Smad2 fusion reporter gene after 90 mins by Hoechst 3342 staining-based cellomics arrayscan imaging analysis | ChEMBL. | 19736928 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.