Detailed information for compound 1074364

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 488.414 | Formula: C17H19Cl2N7O2S2
  • H donors: 3 H acceptors: 3 LogP: 4.41 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=N)N/N=C/1\CC(c2c1cc(cc2)NS(=O)(=O)c1c(Cl)nc2n1ccs2)(C)C.Cl
  • InChi: 1S/C17H18ClN7O2S2.ClH/c1-17(2)8-12(22-23-15(19)20)10-7-9(3-4-11(10)17)24-29(26,27)14-13(18)21-16-25(14)5-6-28-16;/h3-7,24H,8H2,1-2H3,(H4,19,20,23);1H/b22-12+;
  • InChiKey: UWUHWESFQAUGMF-RSRKELGKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 4 Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_145685 All targets in OG5_145685
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_145685 All targets in OG5_145685
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Serotonin receptor Get druggable targets OG5_135430 All targets in OG5_135430
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 4 630 aa 574 aa 31.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.0517 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0075 0.0292 0.3792
Brugia malayi ecdysone receptor 0.0064 0.0222 0.0636
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0077 0.018
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0136 0.0675 0.5105
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0623 0.1524
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0136 0.0675 0.1972
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0032 0.032
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0158 0.0814 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.0569 0.1439
Brugia malayi Smad1 0.0033 0.0026 0.0056
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0045 0.0101 0.2303
Echinococcus granulosus Nuclear hormone receptor HR96 0.0064 0.0222 0.0359
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.1134 0.2885
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0129 0.0935
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0072 0.0271 0.0264
Echinococcus multilocularis expressed conserved protein 0.009 0.0385 0.0378
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0032 0.0018 0.0125
Schistosoma mansoni hypothetical protein 0.003 0.0009 0.0004
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0026 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0414 0.3107
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0045 0.01 0.122
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.015 0.0243
Trichomonas vaginalis penicillin-binding protein, putative 0.0149 0.0757 0.573
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0202 0.2584
Schistosoma mansoni coup transcription factor 0.0136 0.0675 0.1653
Brugia malayi Serotonin receptor 0.0566 0.3395 1
Brugia malayi Nuclear hormone receptor-like 1 0.0072 0.0271 0.0779
Echinococcus granulosus peptidase Clp S14 family 0.0103 0.0471 0.0759
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.0517 0.1261
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0136 0.0675 0.1653
Mycobacterium tuberculosis Probable dehydrogenase 0.012 0.0576 0.0977
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0064 0.0222 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0261 0.1942
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0114 0.0535 0.0529
Loa Loa (eye worm) hypothetical protein 0.0038 0.0056 0.0125
Brugia malayi hypothetical protein 0.047 0.2786 0.8203
Plasmodium vivax importin-beta 2, putative 0.0061 0.0202 0.2415
Echinococcus multilocularis thyroid hormone receptor alpha 0.0136 0.0675 0.0669
Trypanosoma cruzi target of rapamycin kinase 3 0.0075 0.0292 0.3792
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0136 0.0675 0.1653
Schistosoma mansoni microtubule-associated protein tau 0.067 0.4049 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0032 0.032
Toxoplasma gondii target of rapamycin (TOR), putative 0.007 0.0261 0.3148
Plasmodium vivax hypothetical protein, conserved 0.0149 0.0757 0.929
Loa Loa (eye worm) hypothetical protein 0.0072 0.0271 0.0676
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0136 0.0675 0.1972
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0136 0.0675 0.171
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0054 0.0608
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0045 0.0101 0.0276
Loa Loa (eye worm) hypothetical protein 0.0073 0.0279 0.0697
Echinococcus multilocularis peptidase Clp (S14 family) 0.0103 0.0471 0.0464
Schistosoma mansoni hypothetical protein 0.0096 0.0424 0.1031
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0158 0.0814 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0149 0.0757 0.2213
Mycobacterium leprae Probable lipase LipE 0.0149 0.0757 0.9289
Brugia malayi nuclear receptor NHR-88 0.0064 0.0222 0.0636
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0114 0.0535 0.0863
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0158 0.0814 0.1313
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.0517 0.1305
Loa Loa (eye worm) hypothetical protein 0.0114 0.0535 0.1353
Chlamydia trachomatis pyruvate kinase 0.0034 0.0032 0.0316
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0054 0.0047
Schistosoma mansoni ran 0.0045 0.0101 0.0232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0174 0.1277
Schistosoma mansoni peptidase Clp (S14 family) 0.0158 0.0814 0.1997
Toxoplasma gondii HEAT repeat-containing protein 0.0061 0.0202 0.2415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0174 0.1277
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0517 0.3895
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0064 0.0222 0.0216
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0032 0.0018 0.0029
Loa Loa (eye worm) nuclear receptor NHR-67 0.0064 0.0222 0.0552
Brugia malayi MH1 domain containing protein 0.0033 0.0026 0.0056
Onchocerca volvulus Protein ultraspiracle homolog 0.0136 0.0675 0.5105
Brugia malayi beta-lactamase 0.0149 0.0757 0.2213
Loa Loa (eye worm) norepinephrine transporter 0.0073 0.0279 0.0697
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0136 0.0675 0.1089
Loa Loa (eye worm) hypothetical protein 0.0136 0.0675 0.171
Echinococcus multilocularis 0.003 0.0009 0.0002
Onchocerca volvulus 0.0237 0.1316 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0261 0.1942
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0129 0.1614
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0136 0.0675 0.1972
Loa Loa (eye worm) hypothetical protein 0.0107 0.0491 0.1239
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0136 0.0675 0.1653
Brugia malayi Cytochrome P450 family protein 0.0068 0.0246 0.0706
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0158 0.0814 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.012 0.0576 0.7044
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0032 0.0195
Echinococcus granulosus pyruvate kinase 0.0034 0.0032 0.0052
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0054 0.0161 0.1897
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0359 0.2085 0.5318
Mycobacterium tuberculosis Probable oxidoreductase 0.0133 0.0661 0.1123
Trypanosoma brucei hypothetical protein, conserved 0.0149 0.0757 1
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0032 0.0316
Brugia malayi Cytochrome P450 family protein 0.0068 0.0246 0.0706
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0158 0.0814 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0064 0.0222 0.0216
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0094 0.0414 0.7978
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0026 0.0048
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0032 0.032
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.0424 0.123
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0026 0.0042
Schistosoma mansoni cytochrome P450 0.003 0.0009 0.0004
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0422 0.8138
Schistosoma mansoni pyruvate kinase 0.0034 0.0032 0.0063
Onchocerca volvulus 0.0107 0.0491 0.37
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0158 0.0814 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0032 0.0018 0.0125
Brugia malayi CHE-14 protein 0.0041 0.0077 0.0207
Onchocerca volvulus Bile acid receptor homolog 0.0136 0.0675 0.5105
Echinococcus granulosus biogenic amine 5HT receptor 0.0158 0.0816 0.1315
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0136 0.0675 0.1972
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0133 0.0661 0.1123
Echinococcus granulosus tumor protein p63 0.0728 0.4416 0.7121
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0054 0.012
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0032 0.032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0292 0.2177
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.012 0.0576 0.0977
Brugia malayi nuclear hormone receptor family member odr-7 0.0064 0.0222 0.0636
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.015 0.1778
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0136 0.0675 0.1972
Loa Loa (eye worm) hypothetical protein 0.0136 0.0675 0.171
Schistosoma mansoni Smad4 0.0033 0.0026 0.0047
Echinococcus multilocularis serotonin transporter 0.0073 0.0279 0.0272
Echinococcus granulosus GPCR family 2 0.0114 0.0535 0.0863
Echinococcus granulosus Nuclear hormone receptor HR96 0.0064 0.0222 0.0359
Loa Loa (eye worm) hypothetical protein 0.0064 0.0222 0.0552
Brugia malayi hypothetical protein 0.0072 0.0271 0.0779
Onchocerca volvulus 0.0073 0.0279 0.208
Loa Loa (eye worm) latrophilin receptor protein 2 0.0114 0.0535 0.1353
Brugia malayi beta-lactamase family protein 0.0149 0.0757 0.2213
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0094 0.0414 0.1006
Onchocerca volvulus 0.0149 0.0757 0.573
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0114 0.0535 0.0863
Schistosoma mansoni hypothetical protein 0.0114 0.0535 0.1308
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0158 0.0814 1
Brugia malayi cytochrome P450 0.003 0.0009 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0063 0.0218 0.161
Mycobacterium tuberculosis Probable lipase LipD 0.0149 0.0757 0.1289
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0032 0.0041
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0103 0.0471 0.5741
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0073 0.0279 0.0674
Loa Loa (eye worm) hypothetical protein 0.0136 0.0675 0.171
Toxoplasma gondii cytochrome p450 superfamily protein 0.003 0.0009 0.002
Brugia malayi MH1 domain containing protein 0.0033 0.0026 0.0056
Brugia malayi MH2 domain containing protein 0.0033 0.0026 0.0056
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0026 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0136 0.0675 0.1972
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0064 0.0222 0.0216
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0054 0.0139
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0032 0.0297
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0136 0.0675 0.1653
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0517 0.3895
Loa Loa (eye worm) hypothetical protein 0.0064 0.0222 0.0552
Echinococcus granulosus cytochrome P450 2K1 0.003 0.0009 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0136 0.0675 0.1972
Loa Loa (eye worm) hypothetical protein 0.0072 0.0271 0.0676
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0045 0.0101 0.116
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0054 0.0087
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0077 0.0125
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0032 0.0195
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0158 0.0814 1
Entamoeba histolytica Ran family GTPase 0.0045 0.0101 0.1837
Echinococcus multilocularis survival motor neuron protein 1 0.047 0.2786 0.2781
Onchocerca volvulus 0.0064 0.0222 0.1646
Echinococcus granulosus pyruvate kinase 0.0034 0.0032 0.0052
Loa Loa (eye worm) hypothetical protein 0.0158 0.0816 0.207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0205 0.1511
Echinococcus multilocularis snurportin 1 0.0649 0.3914 0.391
Brugia malayi phosphofructokinase 0.0111 0.0517 0.1504
Loa Loa (eye worm) hypothetical protein 0.0064 0.0222 0.0552
Schistosoma mansoni patched 1 0.0041 0.0077 0.0174
Loa Loa (eye worm) hypothetical protein 0.0158 0.0814 0.2066
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0064 0.0222 0.0359
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0032 0.0018 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0261 0.1942
Echinococcus multilocularis Smad4 0.0033 0.0026 0.0019
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0136 0.0675 0.1972
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0039 0.0032
Entamoeba histolytica hypothetical protein 0.0035 0.0039 0.0625
Trypanosoma cruzi cytochrome P450, putative 0.0068 0.0246 0.3175
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0431 0.1049
Brugia malayi hypothetical protein 0.0035 0.0039 0.0094
Brugia malayi latrophilin 2 splice variant baaae 0.0245 0.1368 0.4016
Loa Loa (eye worm) hypothetical protein 0.0064 0.0222 0.0552
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0094 0.0414 0.0667
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0158 0.0814 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0129 0.0935
Echinococcus multilocularis tumor protein p63 0.0728 0.4416 0.4412
Loa Loa (eye worm) hypothetical protein 0.0064 0.0222 0.0552
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0039 0.0063
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0054 0.0608
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0018 0.0032
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0202 0.2584
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0149 0.0757 0.1289
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0054 0.0078
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0072 0.0271 0.0676
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.0517 0.6791
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.017 0.125
Loa Loa (eye worm) hypothetical protein 0.0041 0.0077 0.018
Echinococcus granulosus 6 phosphofructokinase 0.0111 0.0517 0.0833
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0136 0.0675 0.1653
Loa Loa (eye worm) hypothetical protein 0.0159 0.0822 0.2086
Brugia malayi Nuclear hormone receptor E75 0.0064 0.0222 0.0636
Brugia malayi Steroid receptor seven-up type 2 0.0223 0.1226 0.3598
Schistosoma mansoni nuclear hormone receptor 0.0064 0.0222 0.0533
Schistosoma mansoni ran 0.0045 0.0101 0.0232
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0136 0.0675 0.1089
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0111 0.0517 0.6308
Brugia malayi nuclear hormone receptor 0.0136 0.0675 0.1972
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0101 0.123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.014 0.1015
Echinococcus granulosus ecdysone induced protein 78C 0.0136 0.0675 0.1089
Schistosoma mansoni retinoic acid receptor RXR 0.0136 0.0675 0.1653
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0054 0.1157
Loa Loa (eye worm) cytochrome P450 family protein 0.0111 0.0517 0.1306
Loa Loa (eye worm) hypothetical protein 0.0136 0.0675 0.171
Mycobacterium tuberculosis Probable hydrolase 0.0149 0.0757 0.1289
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0149 0.0757 0.1855
Echinococcus granulosus serotonin transporter 0.0073 0.0279 0.045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0139 0.1011
Loa Loa (eye worm) cytochrome P450 0.003 0.0009 0.0004
Toxoplasma gondii hypothetical protein 0.0054 0.0161 0.1913
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0094 0.0414 0.5414
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0018 0.0084
Loa Loa (eye worm) solute carrier family 6 member 4 0.0073 0.0279 0.0697
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0064 0.0222 0.0533
Loa Loa (eye worm) hypothetical protein 0.0073 0.0279 0.0697
Schistosoma mansoni steroid hormone receptor ad4bp 0.0136 0.0675 0.1653
Brugia malayi Latrophilin receptor protein 2 0.0114 0.0535 0.156
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0623 0.1524
Plasmodium falciparum importin beta, putative 0.0061 0.0202 0.2415
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0114 0.0535 0.156
Brugia malayi nuclear receptor RXR 0.0064 0.0222 0.0636
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0133 0.0661 0.1123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0018 0.0084
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0359 0.2085 0.6133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0139 0.1011
Toxoplasma gondii thioredoxin reductase 0.0053 0.015 0.1778
Schistosoma mansoni nuclear receptor 0.0064 0.0222 0.0533
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0153 0.0787 0.1268
Echinococcus granulosus FTZ F1 alpha 0.0136 0.0675 0.1089
Schistosoma mansoni RAR-like nuclear receptor 0.0136 0.0675 0.1653
Echinococcus multilocularis FTZ F1 alpha 0.0136 0.0675 0.0669
Loa Loa (eye worm) hypothetical protein 0.0136 0.0675 0.171
Loa Loa (eye worm) hypothetical protein 0.0136 0.0675 0.171
Loa Loa (eye worm) hypothetical protein 0.0096 0.0422 0.1062
Echinococcus granulosus expressed conserved protein 0.009 0.0385 0.0621
Loa Loa (eye worm) hypothetical protein 0.0245 0.1368 0.3483
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0261 0.1942
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0149 0.0757 0.1289
Schistosoma mansoni smad 0.0033 0.0026 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0136 0.0675 0.171
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.0681 0.0674
Trichomonas vaginalis set domain proteins, putative 0.0237 0.1316 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0223 0.1226 0.1977
Schistosoma mansoni hypothetical protein 0.0114 0.0535 0.1308
Trichomonas vaginalis esterase, putative 0.0149 0.0757 0.573
Loa Loa (eye worm) hypothetical protein 0.0149 0.0757 0.1919
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0072 0.0271 0.0437
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0261 0.1942
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0422 0.1224
Echinococcus multilocularis pyruvate kinase 0.0034 0.0032 0.0026
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0054 0.0583
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.0787 0.1929
Giardia lamblia GTOR 0.0094 0.0414 1
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.015 0.1896
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.0517 0.6791
Plasmodium falciparum thioredoxin reductase 0.0053 0.015 0.1778
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0327 0.2442
Toxoplasma gondii exonuclease III APE 0.0037 0.0054 0.0583
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0136 0.0675 0.1972
Schistosoma mansoni ap endonuclease 0.0037 0.0054 0.0116
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0075 0.0292 0.3792
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0139 0.1011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0136 0.0675 0.171
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.0517 1
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0032 0.0316
Brugia malayi nuclear hormone receptor family member nhr-6 0.0064 0.0222 0.0636
Loa Loa (eye worm) MH2 domain-containing protein 0.0483 0.2865 0.7316
Onchocerca volvulus 0.0149 0.0757 0.573
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0136 0.0675 0.1653
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.014 0.1015
Echinococcus multilocularis protein patched 0.0041 0.0077 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.014 0.1015
Mycobacterium tuberculosis Probable reductase 0.012 0.0576 0.0977
Loa Loa (eye worm) phosphatidylinositol 3 0.0094 0.0414 0.1041
Schistosoma mansoni hypothetical protein 0.004 0.0068 0.0151
Leishmania major pyruvate kinase 0.0034 0.0032 0.032
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0136 0.0675 0.1089
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0032 0.0195
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0064 0.0222 0.0216
Loa Loa (eye worm) phosphatidylinositol 3 0.0032 0.0018 0.0028
Schistosoma mansoni zinc finger protein 0.0064 0.0222 0.0533
Plasmodium falciparum glutathione reductase 0.0053 0.015 0.1778
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0045 0.0101 0.116
Loa Loa (eye worm) transcription factor SMAD2 0.0483 0.2865 0.7316
Loa Loa (eye worm) hypothetical protein 0.0136 0.0675 0.171
Echinococcus granulosus thyroid hormone receptor alpha 0.0064 0.0222 0.0359
Schistosoma mansoni hypothetical protein 0.0532 0.3177 0.7843
Loa Loa (eye worm) hypothetical protein 0.0149 0.0757 0.1919
Leishmania major cytochrome p450-like protein 0.0068 0.0246 0.3175
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0064 0.0222 0.0533
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0153 0.0787 0.078
Echinococcus multilocularis serotonin receptor 0.0158 0.0816 0.0809
Schistosoma mansoni smad1 5 8 and 0.0033 0.0026 0.0047
Echinococcus granulosus tm gpcr rhodopsin 0.1011 0.6202 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0045 0.0101 0.0094
Toxoplasma gondii ABC1 family protein 0.0149 0.0757 0.929
Echinococcus multilocularis tar DNA binding protein 0.0127 0.0623 0.0617
Entamoeba histolytica hypothetical protein 0.0035 0.0039 0.0625
Brugia malayi orphan nuclear receptor NR2E1 0.0064 0.0222 0.0636
Loa Loa (eye worm) hypothetical protein 0.005 0.0135 0.0329
Leishmania major phosphatidylinositol 3-kinase, putative 0.0032 0.0018 0.0125
Loa Loa (eye worm) hypothetical protein 0.0064 0.0222 0.0552
Schistosoma mansoni pyruvate kinase 0.0034 0.0032 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0174 0.1277
Loa Loa (eye worm) hypothetical protein 0.0061 0.0202 0.0499
Loa Loa (eye worm) hypothetical protein 0.0153 0.0787 0.1996
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0094 0.0414 0.5414
Loa Loa (eye worm) DR-78 0.0064 0.0222 0.0552
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0149 0.0757 0.1289
Echinococcus granulosus survival motor neuron protein 1 0.047 0.2786 0.4493
Entamoeba histolytica hypothetical protein 0.0035 0.0039 0.0625
Brugia malayi RNA binding protein 0.0127 0.0623 0.1818
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0114 0.0535 0.0529
Brugia malayi hypothetical protein 0.0064 0.0222 0.0636
Brugia malayi conserved hypotetical protein 0.0064 0.0222 0.0636
Entamoeba histolytica hypothetical protein 0.0035 0.0039 0.0625
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0032 0.0018 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0292 0.2177
Giardia lamblia Pyruvate kinase 0.0034 0.0032 0.0627
Trypanosoma cruzi cytochrome P450, putative 0.0068 0.0246 0.3175
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0039 0.0079
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0026 0.0042
Loa Loa (eye worm) hypothetical protein 0.0064 0.0222 0.0552
Loa Loa (eye worm) glutathione reductase 0.0053 0.015 0.0367
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0094 0.0414 0.12
Schistosoma mansoni survival motor neuron protein 0.0096 0.0424 0.1031
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0136 0.0675 0.0669
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0623 0.1524
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.014 0.1015
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0064 0.0222 0.1646
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0032 0.0075
Echinococcus granulosus snurportin 1 0.0649 0.3914 0.6311
Echinococcus granulosus Smad4 0.0033 0.0026 0.0042
Schistosoma mansoni nuclear receptor nhr-48 0.0064 0.0222 0.0533
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.0787 0.1929
Brugia malayi Nuclear hormone receptor E75 0.0064 0.0222 0.0636
Loa Loa (eye worm) hypothetical protein 0.0158 0.0816 0.207
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0136 0.0675 0.1972
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0054 0.036
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0136 0.0675 0.0669
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.015 0.0367
Schistosoma mansoni ap endonuclease 0.0037 0.0054 0.0116
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0094 0.0414 0.5414
Loa Loa (eye worm) hypothetical protein 0.0149 0.0757 0.1919
Mycobacterium tuberculosis Probable esterase LipL 0.0149 0.0757 0.1289
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.017 0.125
Onchocerca volvulus 0.0096 0.0424 0.3184
Loa Loa (eye worm) hypothetical protein 0.0149 0.0757 0.1919
Trichomonas vaginalis D-aminoacylase, putative 0.0149 0.0757 0.573
Brugia malayi MH2 domain containing protein 0.0033 0.0026 0.0056
Mycobacterium tuberculosis Conserved protein 0.0149 0.0757 0.1289
Mycobacterium tuberculosis Putative ferredoxin reductase 0.012 0.0576 0.0977
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0018 0.0084
Onchocerca volvulus Huntingtin homolog 0.0119 0.0569 0.4296
Trypanosoma brucei cytochrome P450, putative 0.0068 0.0246 0.3175
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0026 0.0019
Schistosoma mansoni hypothetical protein 0.0035 0.0039 0.0079
Brugia malayi 6-phosphofructokinase 0.0111 0.0517 0.1504
Loa Loa (eye worm) hypothetical protein 0.0034 0.0032 0.0065
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.0517 0.1261
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0068 0.0246 0.2949
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0292 0.2177
Mycobacterium ulcerans esterase/lipase LipP 0.0149 0.0757 0.9289
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0064 0.0222 0.1646
Brugia malayi Cytochrome P450 family protein 0.0111 0.0517 0.1506
Loa Loa (eye worm) hypothetical protein 0.0072 0.0271 0.0676
Schistosoma mansoni hypothetical protein 0.0114 0.0535 0.1308
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0054 0.0923
Schistosoma mansoni importin beta-1 0.0061 0.0202 0.0482
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0032 0.0018 0.0011
Echinococcus multilocularis beta LACTamase domain containing family member 0.0149 0.0757 0.075
Mycobacterium ulcerans 6-phosphofructokinase 0.0111 0.0517 0.6308
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0136 0.0675 0.0669
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0153 0.0787 0.1996
Echinococcus multilocularis smad 0.0033 0.0026 0.0019
Onchocerca volvulus 0.0064 0.0222 0.1646
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0158 0.0814 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0136 0.0675 0.1089
Echinococcus granulosus geminin 0.0532 0.3177 0.5122
Trypanosoma brucei trypanothione reductase 0.0053 0.015 0.1896
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0136 0.0675 0.171
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0649 0.3914 1
Brugia malayi MH2 domain containing protein 0.0483 0.2865 0.8436
Echinococcus multilocularis pyruvate kinase 0.0034 0.0032 0.0026
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0623 0.1524
Loa Loa (eye worm) cytochrome P450 family protein 0.0068 0.0246 0.0612
Plasmodium vivax glutathione reductase, putative 0.0053 0.015 0.1778
Schistosoma mansoni nuclear receptor 0.0064 0.0222 0.0533
Echinococcus multilocularis 6 phosphofructokinase 0.0111 0.0517 0.051
Entamoeba histolytica hypothetical protein 0.0049 0.0129 0.2401
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.0623 0.1577
Loa Loa (eye worm) Smad1 0.0033 0.0026 0.0048
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0032 0.0195
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0158 0.0814 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0054 0.0583
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0133 0.0661 0.8094
Onchocerca volvulus 0.0136 0.0675 0.5105
Mycobacterium tuberculosis Conserved protein 0.0149 0.0757 0.1289
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0414 0.3107
Echinococcus multilocularis protein dispatched 1 0.0047 0.0114 0.0107
Loa Loa (eye worm) cytochrome P450 family protein 0.0068 0.0246 0.0612
Brugia malayi hypothetical protein 0.0072 0.0271 0.0779
Brugia malayi beta-lactamase family protein 0.0149 0.0757 0.2213
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0054 0.0583
Brugia malayi hypothetical protein 0.0153 0.0787 0.2301
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0054 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0292 0.2177
Loa Loa (eye worm) CYP4Cod1 0.0068 0.0246 0.0612
Brugia malayi hypothetical protein 0.0064 0.0222 0.0636
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0039 0.0066 0.0762
Brugia malayi Pre-SET motif family protein 0.0208 0.1134 0.3326
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0032 0.0195
Trichomonas vaginalis penicillin-binding protein, putative 0.0149 0.0757 0.573
Brugia malayi nuclear receptor RXR 0.0072 0.0271 0.0779
Loa Loa (eye worm) hypothetical protein 0.0064 0.0222 0.0552
Schistosoma mansoni sodium/chloride dependent transporter 0.0073 0.0279 0.0674
Trichomonas vaginalis ran, putative 0.0045 0.0101 0.0716
Schistosoma mansoni hypothetical protein 0.004 0.0068 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0018 0.0084
Schistosoma mansoni hypothetical protein 0.0114 0.0535 0.1308
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0136 0.0675 0.0669
Brugia malayi RNA, U transporter 1 0.0173 0.0909 0.2663
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.0623 0.1818
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0422 0.068
Brugia malayi Thioredoxin reductase 0.0053 0.015 0.0423
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0149 0.0757 0.9289
Brugia malayi nuclear receptor NHR-67 0.0064 0.0222 0.0636
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0045 0.0101 0.123
Brugia malayi nuclear hormone receptor 0.0064 0.0222 0.0636
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0129 0.0935
Echinococcus multilocularis geminin 0.0532 0.3177 0.3172
Trypanosoma cruzi hypothetical protein, conserved 0.0149 0.0757 1
Schistosoma mansoni thyroid hormone receptor 0.0136 0.0675 0.1653
Loa Loa (eye worm) TAR-binding protein 0.0127 0.0623 0.1577
Loa Loa (eye worm) hypothetical protein 0.0136 0.0675 0.171
Echinococcus multilocularis serotonin receptor 0.0158 0.0816 0.0809
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0094 0.0414 0.5414
Brugia malayi steroid hormone receptor 0.0136 0.0675 0.1972
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0103 0.0471 0.0797
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0054 0.0161 0.1913
Echinococcus granulosus microtubule associated protein 2 0.067 0.4049 0.6528
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0032 0.0018 0.0125
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0064 0.0222 0.0359
Echinococcus granulosus tar DNA binding protein 0.0127 0.0623 0.1005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0136 0.0675 0.171
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0032 0.0065
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0032 0.0065
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0153 0.0787 0.2301
Mycobacterium ulcerans lipase LipD 0.0149 0.0757 0.9289
Brugia malayi Nuclear hormone receptor-like 1 0.0072 0.0271 0.0779
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0136 0.0675 0.0669
Echinococcus granulosus smad 0.0033 0.0026 0.0042
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.012 0.0576 0.0977
Schistosoma mansoni smad1 5 8 and 0.0033 0.0026 0.0047
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0158 0.0814 0.0808
Onchocerca volvulus 0.0149 0.0757 0.573
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0517 0.3895
Leishmania major importin beta-1 subunit, putative 0.0049 0.0129 0.1614
Brugia malayi TAR-binding protein 0.0127 0.0623 0.1818
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0261 0.1942
Loa Loa (eye worm) hypothetical protein 0.0359 0.2085 0.5318
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0054 0.0565
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0026 0.0048
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0517 0.3895
Brugia malayi glutathione reductase 0.0053 0.015 0.0423
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0072 0.0271 0.0653
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0064 0.0222 0.0636
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.0681 0.1098
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0007 0.0011
Brugia malayi tailless protein 0.0064 0.0222 0.0636
Loa Loa (eye worm) hypothetical protein 0.0073 0.0279 0.0697
Echinococcus granulosus importin subunit beta 1 0.0061 0.0202 0.0326
Echinococcus multilocularis importin subunit beta 1 0.0061 0.0202 0.0195
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.012 0.0576 0.0977
Mycobacterium leprae conserved hypothetical protein 0.0149 0.0757 0.9289
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0292 0.2177
Echinococcus multilocularis GPCR, family 2 0.0114 0.0535 0.0529
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0149 0.0757 0.1919
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.0517 0.1305
Loa Loa (eye worm) phosphofructokinase 0.0111 0.0517 0.1305
Mycobacterium ulcerans hypothetical protein 0.0149 0.0757 0.9289
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.0787 0.1929
Brugia malayi Probable ClpP-like protease 0.0158 0.0814 0.2382
Loa Loa (eye worm) hypothetical protein 0.0064 0.0222 0.0552
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0136 0.0675 0.1089
Loa Loa (eye worm) hypothetical protein 0.0149 0.0757 0.1919
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0623 0.1524
Schistosoma mansoni hypothetical protein 0.004 0.0068 0.0151
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0094 0.0414 0.0407
Loa Loa (eye worm) hypothetical protein 0.0149 0.0757 0.1919
Schistosoma mansoni nuclear hormone receptor 0.0064 0.0222 0.0533
Onchocerca volvulus Huntingtin homolog 0.0119 0.0569 0.4296
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0054 0.036
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0422 0.0415
Onchocerca volvulus 0.0153 0.0787 0.5957
Loa Loa (eye worm) serotonin transporter b 0.0073 0.0279 0.0697
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0054 0.0608
Loa Loa (eye worm) hypothetical protein 0.0064 0.0222 0.0552
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0032 0.0297
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0149 0.0757 0.1855
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0136 0.0675 0.1972
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.015 0.0244
Trichomonas vaginalis D-aminoacylase, putative 0.0149 0.0757 0.573
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0054 0.0161 0.1913
Schistosoma mansoni hypothetical protein 0.0532 0.3177 0.7843
Brugia malayi Nuclear hormone receptor-like 1 0.0136 0.0675 0.1972
Loa Loa (eye worm) steroid hormone receptor 0.0136 0.0675 0.171
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0153 0.0787 0.1268
Echinococcus multilocularis microtubule associated protein 2 0.067 0.4049 0.4044
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0158 0.0814 1
Schistosoma mansoni hypothetical protein 0.004 0.0068 0.0151
Loa Loa (eye worm) hypothetical protein 0.047 0.2786 0.7114
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0136 0.0675 0.1972
Echinococcus granulosus GTP binding nuclear protein Ran 0.0045 0.0101 0.0162
Loa Loa (eye worm) nuclear hormone receptor 0.0151 0.0773 0.1962
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0136 0.0675 0.1089
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.015 0.0144
Schistosoma mansoni hypothetical protein 0.0649 0.3914 0.9667
Loa Loa (eye worm) hypothetical protein 0.0064 0.0222 0.0552
Brugia malayi Cytochrome P450 family protein 0.003 0.0009 0.0005
Mycobacterium ulcerans beta-lactamase 0.0149 0.0757 0.9289
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0077 0.0125
Brugia malayi nuclear receptor NHR-88 0.0136 0.0675 0.1972
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0077 0.0537
Mycobacterium tuberculosis Possible penicillin-binding protein 0.095 0.5815 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0136 0.0675 0.1972
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0077 0.007
Loa Loa (eye worm) hypothetical protein 0.0072 0.0271 0.0676
Leishmania major pyruvate kinase 0.0034 0.0032 0.032
Brugia malayi ecdysteroid receptor 0.0136 0.0675 0.1972
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0094 0.0414 0.5414
Echinococcus multilocularis nuclear receptor nhr 48 0.0064 0.0222 0.0216
Schistosoma mansoni thyroid hormone receptor 0.0136 0.0675 0.1653
Loa Loa (eye worm) beta-lactamase 0.0149 0.0757 0.1919
Schistosoma mansoni biogenic amine (5HT) receptor 0.0158 0.0816 0.2001
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0103 0.0471 0.0797
Echinococcus granulosus beta LACTamase domain containing family member 0.0149 0.0757 0.122
Plasmodium falciparum pyruvate kinase 0.0034 0.0032 0.0316
Brugia malayi Importin beta-1 subunit 0.0061 0.0202 0.0575
Loa Loa (eye worm) hypothetical protein 0.0119 0.0569 0.1439
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0018 0.0084
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0136 0.0675 0.171
Echinococcus granulosus nuclear receptor nhr 48 0.0064 0.0222 0.0359
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0153 0.0787 0.078
Loa Loa (eye worm) hypothetical protein 0.0064 0.0222 0.0552
Mycobacterium tuberculosis Conserved protein 0.0149 0.0757 0.1289
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0032 0.0018 0.0125
Leishmania major trypanothione reductase 0.0053 0.015 0.1896
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0032 0.0065
Trypanosoma cruzi hypothetical protein, conserved 0.0149 0.0757 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0136 0.0675 0.0669
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0223 0.1226 0.122
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0045 0.0101 0.024
Schistosoma mansoni cellular tumor antigen P53 0.0107 0.0491 0.1198
Brugia malayi hypothetical protein 0.0119 0.0569 0.166
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0136 0.0675 0.171
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0064 0.0222 0.0552
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0111 0.0517 0.0875
Brugia malayi Calcitonin receptor-like protein seb-1 0.0359 0.2085 0.6133
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0101 0.123
Leishmania major GTP-binding protein, putative 0.0045 0.0101 0.123
Loa Loa (eye worm) RNA binding protein 0.0127 0.0623 0.1577
Mycobacterium tuberculosis Probable lipase LipE 0.0149 0.0757 0.1289
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1011 0.6202 0.6199
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0072 0.0271 0.0653
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0032 0.0075
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.0517 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0222 0.0552
Schistosoma mansoni smad1 5 8 and 0.0033 0.0026 0.0047
Brugia malayi 6-phosphofructokinase 0.0111 0.0517 0.1504
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0073 0.0279 0.0803
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0136 0.0675 0.1972
Treponema pallidum sodium- and chloride- dependent transporter 0.0073 0.0279 0.3373
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0094 0.0414 0.7978
Schistosoma mansoni nuclear hormone receptor 0.0136 0.0675 0.1653
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0111 0.0517 0.6315
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0094 0.0414 0.5414
Leishmania major ATP-dependent phosphofructokinase 0.0111 0.0517 0.6791
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0261 0.1942
Leishmania major hypothetical protein, conserved 0.0149 0.0757 1
Trichomonas vaginalis D-aminoacylase, putative 0.0149 0.0757 0.573
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0045 0.0101 0.116
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0054 0.0161 0.1913
Schistosoma mansoni hypothetical protein 0.0245 0.1368 0.3367
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0414 0.3107

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 1 10'3nM Inhibition of human 5HT1A receptor ChEMBL. 19739674
IC50 (binding) > 1 10'3nM Inhibition of human 5HT2C receptor ChEMBL. 19739674
IC50 (binding) > 1 10'4nM Inhibition of human SERT ChEMBL. 19739674
IC50 (functional) = 238 nM Antagonist activity at human 5HT6 receptor expressed in HEK293F cells assessed as inhibition of 5-HT-stimulated cAMP production after 30 mins by HTRF assay ChEMBL. 19739674
Imax (functional) = 146 % Antagonist activity at human 5HT6 receptor expressed in HEK293F cells assessed as inhibition of 5-HT-stimulated cAMP production at 10 uL after 30 mins by HTRF assay relative to (+/-)-6-chloro-N-(3-(1-methylpyrrolidin-3-yl)-1H-inden-5-yl)imidazo[2,1-b]thiazole-5-sulfonamide ChEMBL. 19739674
Inhibition (binding) > 80 % Inhibition of [3H]LSD binding to human recombinant 5HT6 receptor expressed in HEK293 cells at 100 nM after 60 mins by liquid scintillation counting ChEMBL. 19739674
Ki (binding) = 5.2 nM Displacement of [3H]LSD from human recombinant 5HT6 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting ChEMBL. 19739674

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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