Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.7181 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.423 | 0.423 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0099 | 0.7276 | 0.6403 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0098 | 0.7181 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.7181 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0099 | 0.7276 | 0.6403 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.7181 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0114 | 0.9155 | 0.8884 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0099 | 0.7276 | 0.6403 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.423 | 0.423 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.006 | 0.2427 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0054 | 0.1795 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.423 | 0.423 |
Schistosoma mansoni | kinase | 0.005 | 0.1228 | 0.1228 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.2279 | 0.2279 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.423 | 0.423 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0099 | 0.7276 | 0.7276 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.2279 | 0.2279 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0098 | 0.7181 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 0.423 | 0.423 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.423 | 0.423 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0099 | 0.7276 | 0.7276 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0099 | 0.7276 | 0.6403 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0099 | 0.7276 | 0.7276 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0099 | 0.7276 | 0.7276 |
Brugia malayi | TAR-binding protein | 0.0074 | 0.423 | 0.423 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0056 | 0.1932 | 0.1932 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0099 | 0.7276 | 0.7276 |
Schistosoma mansoni | lipoxygenase | 0.0114 | 0.9155 | 0.9155 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.2279 | 0.2279 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0054 | 0.1795 | 0.5 |
Brugia malayi | hypothetical protein | 0.0054 | 0.1795 | 0.1795 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.006 | 0.2427 | 0.5 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.006 | 0.2427 | 0.2427 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.423 | 0.423 |
Schistosoma mansoni | lipoxygenase | 0.008 | 0.4918 | 0.4918 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0098 | 0.7181 | 0.7181 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0098 | 0.7181 | 0.7181 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 0.423 | 0.238 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0098 | 0.7181 | 0.7181 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.006 | 0.2427 | 0.2427 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0098 | 0.7181 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0054 | 0.1795 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.7181 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0098 | 0.7181 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.2279 | 0.2279 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.7181 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.423 | 0.423 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1795 | 0.1795 |
Giardia lamblia | Kinase, PLK | 0.0098 | 0.7181 | 0.5 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.006 | 0.2427 | 0.1174 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.7181 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.7181 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0098 | 0.7181 | 0.6277 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0114 | 0.9155 | 0.8884 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.006 | 0.2427 | 0.5 |
Brugia malayi | RNA binding protein | 0.0074 | 0.423 | 0.423 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0098 | 0.7181 | 0.6277 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0054 | 0.1795 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 0.423 | 0.238 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0098 | 0.7181 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.423 | 0.423 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 0.9 microM | Growth inhibition of human HCC2998 cells after 48 hrs | ChEMBL. | 19939520 |
GI50 (functional) | = 2.8 microM | Growth inhibition of human UACC257 cells after 48 hrs | ChEMBL. | 19939520 |
GI50 (functional) | = 4.2 microM | Growth inhibition of human MCF7 cells after 48 hrs | ChEMBL. | 19939520 |
GI50 (functional) | = 4.5 microM | Growth inhibition of human Melanoma cells after 48 hrs | ChEMBL. | 19939520 |
GI50 (functional) | = 10.5 microM | Growth inhibition of human NSCLC cell after 48 hrs | ChEMBL. | 19939520 |
GI50 (functional) | = 30.3 microM | Growth inhibition of human Leukemia cells after 48 hrs | ChEMBL. | 19939520 |
GI50 (functional) | > 100 micromol/L | Growth inhibition of human EKVX cells after 48 hrs | ChEMBL. | 19939520 |
GI50 (functional) | > 100 micromol/L | Growth inhibition of human OVCAR-3 cells after 48 hrs | ChEMBL. | 19939520 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.