Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | kinase | 0.0051 | 0.1178 | 0.1178 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.2845 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.005 | 0.1133 | 0.3984 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0086 | 0.0086 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0059 | 0.1449 | 0.1575 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0085 | 0.232 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0281 | 0.8923 | 0.8923 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.1022 | 0.0944 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.01 | 0.2845 | 0.2845 |
Brugia malayi | hypothetical protein | 0.0049 | 0.1124 | 0.1222 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0118 | 0.3441 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0289 | 0.9196 | 0.9196 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.2845 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1022 | 0.1022 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0118 | 0.3441 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0106 | 0.3041 | 0.8837 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0089 | 0.0426 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0089 | 0.0258 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0047 | 0.1027 | 0.0949 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0106 | 0.3041 | 0.8837 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0085 | 0.232 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.01 | 0.2845 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0049 | 0.1124 | 0.54 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.1027 | 0.1027 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0078 | 0.2081 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.1022 | 0.1112 |
Leishmania major | trypanothione reductase | 0.0047 | 0.1027 | 0.361 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.2845 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1124 | 0.1047 |
Plasmodium falciparum | thioredoxin reductase | 0.0047 | 0.1027 | 0.4935 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0106 | 0.3041 | 0.8837 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1449 | 0.1374 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0118 | 0.3441 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0047 | 0.1027 | 0.4427 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0089 | 0.0312 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0085 | 0.232 | 0.8154 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0818 | 0.0738 |
Loa Loa (eye worm) | acetyltransferase | 0.0289 | 0.9196 | 0.9189 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.526 | 0.526 |
Echinococcus granulosus | geminin | 0.0172 | 0.526 | 0.526 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.526 | 0.526 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0086 | 0.0086 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0089 | 0.0312 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.2845 | 1 |
Trichomonas vaginalis | importin beta-1, putative | 0.0024 | 0.0256 | 0.0901 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0443 | 0.1557 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0022 | 0.0204 | 0.0204 |
Brugia malayi | glutathione reductase | 0.0047 | 0.1027 | 0.1117 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0118 | 0.3441 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0049 | 0.1124 | 0.395 |
Schistosoma mansoni | importin beta-1 | 0.0029 | 0.0443 | 0.0443 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.1027 | 0.1027 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0047 | 0.1027 | 0.361 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0047 | 0.1027 | 0.4427 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0818 | 0.0818 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0089 | 0.0089 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0085 | 0.232 | 0.232 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0089 | 0.0382 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.2845 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0089 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0049 | 0.1124 | 0.395 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0204 | 0.0204 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.01 | 0.2845 | 0.3094 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0024 | 0.0256 | 0.0901 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1022 | 0.1022 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.01 | 0.2845 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.01 | 0.2845 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | glutathione reductase | 0.0047 | 0.1027 | 0.0949 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0443 | 0.036 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0289 | 0.9196 | 0.9196 |
Brugia malayi | RNA, U transporter 1 | 0.0083 | 0.2264 | 0.2462 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0049 | 0.1124 | 0.4844 |
Leishmania major | importin beta-1 subunit, putative | 0.0024 | 0.0256 | 0.0901 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0089 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0256 | 0.0901 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1022 | 0.1022 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0.1027 | 0.4427 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0085 | 0.232 | 0.8154 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0.0443 | 0.191 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0085 | 0.232 | 1 |
Brugia malayi | Importin beta-1 subunit | 0.0029 | 0.0443 | 0.0482 |
Schistosoma mansoni | serine/threonine protein kinase | 0.01 | 0.2845 | 0.2845 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0086 | 0.0086 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0047 | 0.1027 | 0.2985 |
Plasmodium falciparum | glutathione reductase | 0.0047 | 0.1027 | 0.4935 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0089 | 0.0312 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0089 | 0.0312 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1022 | 0.1022 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0089 | 0.0312 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0089 | 0.0003 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0049 | 0.1124 | 0.4844 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0106 | 0.3041 | 0.8837 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.0443 | 0.0443 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.01 | 0.2845 | 0.2845 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0086 | 0.0086 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0049 | 0.1124 | 0.54 |
Trypanosoma brucei | polo-like protein kinase | 0.01 | 0.2845 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0059 | 0.1449 | 0.1575 |
Giardia lamblia | Kinase, PLK | 0.01 | 0.2845 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0089 | 0.0089 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0089 | 0.0089 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.01 | 0.2845 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.2845 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0089 | 0.0312 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0059 | 0.1449 | 0.1374 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0049 | 0.1124 | 0.395 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0086 | 0.0086 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0086 | 0.0086 |
Echinococcus multilocularis | geminin | 0.0172 | 0.526 | 0.526 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.01 | 0.2845 | 0.2783 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0078 | 0.2081 | 0.7315 |
Trichomonas vaginalis | CAMK family protein kinase | 0.005 | 0.1133 | 0.3984 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0089 | 0.0089 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1022 | 0.1022 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0443 | 0.1557 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0089 | 0.0096 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.0256 | 0.0608 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.2845 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.0818 | 0.0889 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0089 | 0.0312 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0086 | 0.0086 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0089 | 1 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0078 | 0.2081 | 0.7229 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.01 | 0.2845 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1022 | 0.1022 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0086 | 0.0094 |
Trypanosoma brucei | trypanothione reductase | 0.0047 | 0.1027 | 0.361 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0289 | 0.9196 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.1027 | 0.1117 |
Mycobacterium tuberculosis | Probable reductase | 0.0106 | 0.3041 | 0.8837 |
Leishmania major | hypothetical protein, conserved | 0.0049 | 0.1124 | 0.395 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0106 | 0.3041 | 0.8837 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0089 | 0.0382 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0.0443 | 0.2129 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1022 | 0.1022 |
Brugia malayi | hypothetical protein | 0.0032 | 0.0532 | 0.0579 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0022 | 0.0204 | 0.0204 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.0443 | 0.191 |
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.0443 | 0.0443 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0256 | 0.0901 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0086 | 0.0094 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.