Detailed information for compound 1074616

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 404.548 | Formula: C16H28N4O4S2
  • H donors: 4 H acceptors: 4 LogP: -0.89 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCCC(=O)N1CC2(C[C@H]1C(=O)NCCCCCC(=O)NO)SCCS2
  • InChi: 1S/C16H28N4O4S2/c17-6-5-14(22)20-11-16(25-8-9-26-16)10-12(20)15(23)18-7-3-1-2-4-13(21)19-24/h12,24H,1-11,17H2,(H,18,23)(H,19,21)/t12-/m0/s1
  • InChiKey: ZDABRJXZPYNMFX-LBPRGKRZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus chromobox protein 1 0.0068 0.075 0.1215
Echinococcus granulosus Niemann Pick C1 protein 0.0217 0.2944 0.4802
Echinococcus multilocularis geminin 0.0179 0.2387 0.3891
Brugia malayi jmjC domain containing protein 0.0243 0.3338 0.3799
Entamoeba histolytica hypothetical protein 0.0115 0.144 0.3405
Schistosoma mansoni bromodomain containing protein 0.0069 0.0769 0.1246
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0057 0.058 0.0938
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0243 0.3338 0.5446
Loa Loa (eye worm) inositol-1 0.0036 0.027 0.0291
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.027 0.029
Schistosoma mansoni cpg binding protein 0.0065 0.0697 0.113
Brugia malayi hypothetical protein 0.0115 0.144 0.1628
Loa Loa (eye worm) hypothetical protein 0.0093 0.1117 0.126
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.4085 0.4085
Echinococcus multilocularis jumonji domain containing protein 0.0079 0.0908 0.1474
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0224 0.0356
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0658 0.0734
Schistosoma mansoni inositol monophosphatase 0.0036 0.027 0.0431
Echinococcus multilocularis PHD finger protein rhinoceros 0.0057 0.058 0.0938
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0106 0.0106
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0474 0.0764
Trichomonas vaginalis chromobox protein, putative 0.0068 0.075 0.075
Schistosoma mansoni importin beta-1 0.003 0.0193 0.0306
Brugia malayi Pre-SET motif family protein 0.0089 0.1053 0.1185
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0267 0.2007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0089 0.1053 0.1711
Onchocerca volvulus 0.01 0.1217 0.1051
Brugia malayi chromobox protein homolog 3 0.0038 0.0307 0.0332
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0307 0.0124
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0474 0.1582
Schistosoma mansoni zinc finger protein 0.0024 0.0095 0.0145
Trypanosoma cruzi hypothetical protein, conserved 0.0214 0.2904 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.027 0.027
Brugia malayi PHD-finger family protein 0.0057 0.058 0.0644
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0307 0.0307
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0241 0.0258
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0297 0.0476
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0107 0.0116
Echinococcus granulosus histone lysine methyltransferase setb 0.0106 0.1316 0.214
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.027 0.0431
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0658 0.1066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0408 0.0656
Leishmania major importin beta-1 subunit, putative 0.0025 0.0108 0.0119
Brugia malayi jmjC domain containing protein 0.0034 0.0241 0.0257
Echinococcus granulosus importin subunit beta 1 0.003 0.0193 0.0306
Loa Loa (eye worm) beta-lactamase 0.0035 0.0267 0.0288
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0034 0.0241 0.1528
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.027 0.0486
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.027 0.027
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0106 0.0106
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.027 0.043
Loa Loa (eye worm) hypothetical protein 0.003 0.0186 0.0194
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0106 0.0106
Echinococcus multilocularis zinc finger protein 0.0024 0.0095 0.0145
Schistosoma mansoni hypothetical protein 0.009 0.1067 0.1734
Schistosoma mansoni chromobox protein 0.0068 0.075 0.1215
Echinococcus multilocularis chromobox protein 1 0.0068 0.075 0.1215
Trypanosoma cruzi hypothetical protein, conserved 0.0214 0.2904 1
Echinococcus multilocularis protein dispatched 1 0.0106 0.1311 0.2133
Echinococcus granulosus geminin 0.0179 0.2387 0.3891
Mycobacterium leprae Probable lipase LipE 0.0035 0.0267 0.0318
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0267 0.0318
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.2114 0.3446
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.4085 1
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0107 0.0116
Echinococcus multilocularis JmjC domain containing protein 4 0.0034 0.0241 0.0384
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0658 0.1066
Schistosoma mansoni jumonji/arid domain-containing protein 0.0132 0.1689 0.2751
Echinococcus granulosus lysine specific demethylase 6a 0.0034 0.0241 0.0384
Mycobacterium ulcerans beta-lactamase 0.0035 0.0267 0.0911
Brugia malayi Heterochromatin protein 1 0.0068 0.075 0.0838
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0474 0.0764
Schistosoma mansoni hypothetical protein 0.0325 0.4545 0.7419
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0658 0.1066
Echinococcus multilocularis Niemann Pick C1 protein 0.0217 0.2944 0.4802
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.027 0.0488
Echinococcus multilocularis lysine specific demethylase 5A 0.0126 0.161 0.2622
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.058 0.3838
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0408 0.0656
Schistosoma mansoni hypothetical protein 0.0179 0.2387 0.3891
Plasmodium vivax importin-beta 2, putative 0.003 0.0193 0.1252
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0474 0.0474
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0618 0.0689
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0294 0.0317
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0474 0.1411
Echinococcus multilocularis importin subunit beta 1 0.003 0.0193 0.0306
Echinococcus multilocularis dnaJ subfamily B 0.0432 0.6123 1
Onchocerca volvulus 0.0059 0.0618 0.0441
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0115 0.144 0.2344
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0075 0.0066
Echinococcus multilocularis chromobox protein 1 0.0068 0.075 0.1215
Loa Loa (eye worm) hypothetical protein 0.0035 0.0267 0.0288
Brugia malayi Niemann-Pick C1 protein precursor 0.0217 0.2944 0.3349
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0267 0.0267
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0108 0.0108
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0008 0.0003
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0478 0.0771
Giardia lamblia Fructose-bisphosphate aldolase 0.0294 0.4085 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.027 0.069
Echinococcus granulosus mixed lineage leukemia protein mll 0.0018 0.0008 0.0003
Loa Loa (eye worm) hypothetical protein 0.0034 0.0241 0.0258
Schistosoma mansoni hypothetical protein 0.009 0.1067 0.1734
Loa Loa (eye worm) hypothetical protein 0.0103 0.1262 0.1425
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0611 0.8757 1
Echinococcus granulosus Protein patched homolog 1 0.0093 0.1117 0.1815
Echinococcus granulosus tar DNA binding protein 0.0062 0.0658 0.1066
Brugia malayi Bromodomain containing protein 0.004 0.0334 0.0362
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0294 0.0548
Schistosoma mansoni cpg binding protein 0.0065 0.0697 0.113
Trichomonas vaginalis chromobox protein, putative 0.0041 0.035 0.035
Brugia malayi F/Y-rich N-terminus family protein 0.0042 0.0361 0.0394
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0408 0.0656
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0039 0.0321 0.0514
Schistosoma mansoni hypothetical protein 0.0033 0.0224 0.0356
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0658 0.0735
Treponema pallidum fructose-bisphosphate aldolase 0.0294 0.4085 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0408 0.0656
Echinococcus granulosus Niemann Pick C1 protein 0.031 0.4317 0.7047
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0224 0.0356
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0075 0.0083
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0034 0.0241 0.0777
Echinococcus granulosus lysine specific demethylase 5A 0.0132 0.1689 0.2751
Echinococcus granulosus chromobox protein 1 0.0068 0.075 0.1215
Schistosoma mansoni alpha glucosidase 0.0036 0.027 0.043
Brugia malayi jmjC domain containing protein 0.0034 0.0241 0.0257
Echinococcus granulosus snurportin 1 0.0325 0.4545 0.7419
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.4085 0.4085
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0108 0.0108
Schistosoma mansoni hypothetical protein 0.0019 0.0017 0.0017
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.1262 0.1424
Echinococcus multilocularis lysine specific demethylase 6a 0.0034 0.0241 0.0384
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0089 0.1053 0.7058
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.1864 0.5889
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0267 0.0536
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0062 0.009
Onchocerca volvulus 0.005 0.0478 0.0298
Brugia malayi Importin beta-1 subunit 0.003 0.0193 0.0202
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0093 0.1117 0.126
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0408 0.0656
Schistosoma mansoni patched 1 0.0093 0.1117 0.1815
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0781 0.0874
Schistosoma mansoni hypothetical protein 0.0432 0.6123 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0141 0.022
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.075 0.0839
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0294 0.0777
Plasmodium vivax JmjC domain containing protein 0.0034 0.0241 0.174
Brugia malayi PHD-finger family protein 0.0029 0.0177 0.0183
Mycobacterium ulcerans hypothetical protein 0.0035 0.0267 0.0911
Schistosoma mansoni cpg binding protein 0.0059 0.0618 0.1
Trypanosoma brucei protein kinase, putative 0.0049 0.0474 0.1582
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.027 0.0692
Brugia malayi PHD-finger family protein 0.0024 0.0096 0.0091
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0193 0.1201
Loa Loa (eye worm) hypothetical protein 0.0035 0.0267 0.0288
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0408 0.0447
Schistosoma mansoni ran 0.0022 0.0075 0.0111
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.027 0.027
Loa Loa (eye worm) MH2 domain-containing protein 0.0238 0.3254 0.3705
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.1117 0.1117
Brugia malayi CXXC zinc finger family protein 0.0059 0.0618 0.0688
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0057 0.058 0.0646
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0084 0.0986 0.1602
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0408 0.0656
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0474 0.1411
Echinococcus granulosus dnaJ subfamily B 0.0432 0.6123 1
Echinococcus multilocularis expressed conserved protein 0.0204 0.275 0.4485
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.027 0.1726
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0294 0.0548
Brugia malayi beta-lactamase 0.0035 0.0267 0.0287
Toxoplasma gondii ABC1 family protein 0.0035 0.0267 0.1707
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0267 0.0536
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0106 0.1316 0.214
Toxoplasma gondii exonuclease III APE 0.0037 0.0294 0.1891
Loa Loa (eye worm) PHD-finger family protein 0.0057 0.058 0.0646
Trichomonas vaginalis chromobox protein, putative 0.0068 0.075 0.075
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0474 0.1411
Plasmodium vivax SET domain protein, putative 0.0089 0.1053 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0143 0.0143
Loa Loa (eye worm) jmjC domain-containing protein 0.0117 0.1471 0.1665
Brugia malayi MAP kinase sur-1 0.0049 0.0474 0.0523
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.035 0.0168
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.4085 0.4085
Echinococcus granulosus JmjC domain containing protein 4 0.0034 0.0241 0.0384
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0224 0.0237
Mycobacterium ulcerans lipase LipD 0.0035 0.0267 0.0911
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0325 0.4545 0.5181
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0075 0.0392
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0307 0.0307
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0075 0.0199
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.027 0.027
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0039 0.0321 0.0514
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0141 0.022
Mycobacterium tuberculosis Conserved protein 0.0035 0.0267 0.0536
Plasmodium falciparum importin beta, putative 0.003 0.0193 0.2411
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0106 0.0106
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0294 0.0294
Giardia lamblia PHD finger protein 15 0.0057 0.058 0.1261
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.1864 1
Onchocerca volvulus 0.0035 0.0267 0.0083
Brugia malayi TAR-binding protein 0.0062 0.0658 0.0734
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0267 0.0267
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0106 0.0106
Echinococcus granulosus phd:f box containing protein 0.0034 0.0241 0.0384
Brugia malayi Bromodomain containing protein 0.0082 0.0949 0.1067
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0062 0.009
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0089 0.1053 0.1711
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.1262 0.1425
Echinococcus granulosus tumor protein p63 0.034 0.4763 0.7776
Trichomonas vaginalis ran, putative 0.0022 0.0075 0.0075
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0294 0.2281
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0267 0.0287
Loa Loa (eye worm) transcription factor SMAD2 0.0238 0.3254 0.3705
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.004 0.0335 0.0365
Schistosoma mansoni hypothetical protein 0.009 0.1067 0.1734
Schistosoma mansoni jumonji/arid domain-containing protein 0.0132 0.1689 0.2751
Plasmodium vivax hypothetical protein, conserved 0.0057 0.058 0.519
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0106 0.1316 0.214
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0215 0.0361
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0267 0.0427
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.027 0.027
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0035 0.0267 0.0288
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.2114 0.2401
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0474 0.0764
Loa Loa (eye worm) hypothetical protein 0.0034 0.0241 0.0258
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.027 0.0486
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0294 0.0777
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.4085 0.4085
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.3091 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0658 0.1066
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.01 0.1217 0.198
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0108 0.0119
Trichomonas vaginalis esterase, putative 0.0035 0.0267 0.0267
Trypanosoma brucei hypothetical protein, conserved 0.0214 0.2904 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0371 0.0407
Loa Loa (eye worm) hypothetical protein 0.0217 0.2944 0.3349
Loa Loa (eye worm) hypothetical protein 0.007 0.0781 0.0876
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0267 0.0267
Schistosoma mansoni inositol monophosphatase 0.0036 0.027 0.0431
Schistosoma mansoni protein phosphatase 2C 0.0034 0.0241 0.0384
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.027 0.027
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0658 0.0735
Trichomonas vaginalis chromobox protein, putative 0.0041 0.035 0.035
Echinococcus multilocularis tumor protein p63 0.034 0.4763 0.7776
Brugia malayi jmjC domain containing protein 0.0034 0.0241 0.0257
Brugia malayi Bromodomain containing protein 0.0059 0.0617 0.0686
Loa Loa (eye worm) hypothetical protein 0.0035 0.0267 0.0288
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.027 0.1721
Schistosoma mansoni ran 0.0022 0.0075 0.0111
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.027 0.027
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.027 0.027
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0267 0.0267
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.027 0.0692
Loa Loa (eye worm) hypothetical protein 0.0038 0.0307 0.0334
Schistosoma mansoni hypothetical protein 0.0179 0.2387 0.3891
Brugia malayi RNA, U transporter 1 0.0087 0.1023 0.115
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0193 0.0611
Trypanosoma brucei glucosidase, putative 0.0036 0.027 0.0875
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0018 0.0008 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0658 0.1066
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.4085 0.4085
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0224 0.0356
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0008 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0267 0.0682
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.1262 0.1424
Loa Loa (eye worm) jmjC domain-containing protein 0.0132 0.1689 0.1915
Loa Loa (eye worm) hypothetical protein 0.0113 0.1406 0.159
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0036 0.0282 0.045
Echinococcus multilocularis peregrin 0.0059 0.0617 0.0998
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0243 0.3338 0.5446
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0224 0.0356
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0294 0.0471
Loa Loa (eye worm) hypothetical protein 0.0033 0.0224 0.0238
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0713 0.1156
Echinococcus multilocularis protein patched 0.0093 0.1117 0.1815
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.0474 0.0995
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0106 0.0106
Brugia malayi jmjC domain containing protein 0.0132 0.1689 0.1914
Entamoeba histolytica hypothetical protein 0.0025 0.0108 0.0084
Echinococcus multilocularis sterol regulatory element binding protein 0.0093 0.1117 0.1815
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.027 0.0692
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.027 0.043
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0474 0.0764
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.1864 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0294 0.4395
Echinococcus multilocularis citrate lyase subunit beta protein 0.0025 0.0107 0.0165
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0107 0.0116
Plasmodium falciparum phd finger protein, putative 0.0057 0.058 1
Brugia malayi CHE-14 protein 0.0093 0.1117 0.1258
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0267 0.0536
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0267 0.0536
Echinococcus multilocularis GPCR, family 2 0.0033 0.0224 0.0356
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0294 0.0319
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0106 0.0106
Schistosoma mansoni jumonji domain containing protein 0.0205 0.2775 0.4525
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.027 0.0431
Echinococcus multilocularis snurportin 1 0.0325 0.4545 0.7419
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0224 0.0237
Brugia malayi beta-lactamase family protein 0.0035 0.0267 0.0287
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0474 0.1411
Echinococcus granulosus peregrin 0.0059 0.0617 0.0998
Entamoeba histolytica hypothetical protein 0.0115 0.144 0.3405
Loa Loa (eye worm) hypothetical protein 0.005 0.0478 0.0529
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.3167 0.3605
Schistosoma mansoni hypothetical protein 0.0115 0.144 0.2344
Loa Loa (eye worm) hypothetical protein 0.0024 0.0096 0.0092
Schistosoma mansoni phd/f-box containing protein 0.0034 0.0241 0.0384
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.4085 0.4085
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0267 0.0911
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0474 0.0524
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0115 0.144 0.2344
Leishmania major hypothetical protein, conserved 0.0034 0.0241 0.0589
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.027 0.0927
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0106 0.1316 0.214
Brugia malayi RNA binding protein 0.0062 0.0658 0.0734
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0075 0.0043
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.027 0.027
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0474 0.0764
Schistosoma mansoni alpha-glucosidase 0.0138 0.1784 0.2906
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0025 0.0107 0.0107
Loa Loa (eye worm) histone methyltransferase 0.0022 0.0062 0.0052
Schistosoma mansoni ap endonuclease 0.0037 0.0294 0.0471
Echinococcus granulosus PHD finger protein rhinoceros 0.0057 0.058 0.0938
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0474 0.0474
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0075 0.0111
Echinococcus granulosus sterol regulatory element binding protein 0.0093 0.1117 0.1815
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0267 0.0267
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.4085 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0267 0.0427
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0075 0.0111
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0297 0.0476
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.2114 0.24
Schistosoma mansoni hypothetical protein 0.0057 0.058 0.0938
Brugia malayi jmjC domain containing protein 0.0034 0.0241 0.0257
Schistosoma mansoni ap endonuclease 0.0037 0.0294 0.0471
Onchocerca volvulus 0.0035 0.0267 0.0083
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0141 0.022
Brugia malayi MH2 domain containing protein 0.0238 0.3254 0.3704
Echinococcus multilocularis jumonji domain containing 1A 0.0034 0.0241 0.0384
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0267 0.0427
Schistosoma mansoni hypothetical protein 0.009 0.1067 0.1734
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0408 0.0448
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0474 0.1411
Loa Loa (eye worm) RNA binding protein 0.0062 0.0658 0.0735
Leishmania major hypothetical protein, conserved 0.0214 0.2904 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.1316 0.1487
Onchocerca volvulus Alhambra homolog 0.0057 0.058 0.0402
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0294 0.0961
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0474 0.0474
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0224 0.0238
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0267 0.0682
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0267 0.0536
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0217 0.2944 0.7154
Schistosoma mansoni jumonji domain containing protein 0.0034 0.0241 0.0384
Echinococcus granulosus zinc finger protein 0.0024 0.0095 0.0145
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0241 0.0258
Schistosoma mansoni hypothetical protein 0.0022 0.0062 0.009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.4085 0.4085
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.027 0.027
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0267 0.0536
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0658 0.1066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0408 0.0656
Loa Loa (eye worm) hypothetical protein 0.0048 0.0451 0.0497
Schistosoma mansoni chromobox protein 0.0068 0.075 0.1215
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0267 0.0911
Brugia malayi Pre-SET motif family protein 0.0611 0.8757 1
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.027 0.069
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0294 0.0777
Loa Loa (eye worm) hypothetical protein 0.0074 0.0833 0.0935
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.027 0.0877
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0267 0.0536
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0267 0.0427
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0062 0.0052
Plasmodium falciparum JmjC domain-containing protein, putative 0.0034 0.0241 0.3353
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.2114 0.3446
Mycobacterium tuberculosis Conserved protein 0.0035 0.0267 0.0536
Echinococcus granulosus cpg binding protein 0.0065 0.0697 0.113
Echinococcus multilocularis phd:f box containing protein 0.0034 0.0241 0.0384
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0014 0.0014
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0294 0.0471
Schistosoma mansoni alpha-glucosidase 0.0138 0.1784 0.2906
Loa Loa (eye worm) hypothetical protein 0.0035 0.0267 0.0288
Schistosoma mansoni niemann-pick C1 (NPC1) 0.022 0.2993 0.4883
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.058 0.3838
Schistosoma mansoni transcription factor LCR-F1 0.0115 0.144 0.2344
Schistosoma mansoni hypothetical protein 0.0033 0.0224 0.0356
Echinococcus multilocularis cpg binding protein 0.0065 0.0697 0.113
Loa Loa (eye worm) hypothetical protein 0.0035 0.0267 0.0288
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0267 0.0288
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0294 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0193 0.0203
Echinococcus granulosus GPCR family 2 0.0033 0.0224 0.0356
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0075 0.0067
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0267 0.0868
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0474 0.0474
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0108 0.0108
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0294 0.0294
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.027 0.0289
Schistosoma mansoni hypothetical protein 0.0033 0.0224 0.0356
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0294 0.0627
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0034 0.0241 0.0384
Leishmania major hypothetical protein, conserved 0.0035 0.0267 0.0682
Echinococcus granulosus jumonji domain containing protein 0.0079 0.0908 0.1474
Schistosoma mansoni hypothetical protein 0.0033 0.0224 0.0356
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0294 0.1064
Schistosoma mansoni hypothetical protein 0.007 0.0781 0.1267
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0034 0.0241 0.0589
Schistosoma mansoni phosphatidylserine receptor 0.0034 0.0241 0.0384
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.2114 0.3446
Echinococcus multilocularis Niemann Pick C1 protein 0.031 0.4317 0.7047
Echinococcus granulosus expressed conserved protein 0.0204 0.275 0.4485
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0014 0.0014
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.1646 0.2681
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0034 0.0241 0.0589
Brugia malayi follicle stimulating hormone receptor 0.0232 0.3167 0.3604
Toxoplasma gondii histone lysine methyltransferase SET1 0.0118 0.1484 1
Echinococcus granulosus jumonji domain containing 1A 0.0034 0.0241 0.0384
Onchocerca volvulus 0.0093 0.1115 0.0947
Onchocerca volvulus 0.0035 0.0267 0.0083
Brugia malayi Inositol-1 0.0036 0.027 0.029
Brugia malayi beta-lactamase family protein 0.0035 0.0267 0.0287
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.027 0.027
Mycobacterium tuberculosis Conserved protein 0.0035 0.0267 0.0536
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0474 0.3113
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.4085 0.4085
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0474 0.1411
Entamoeba histolytica hypothetical protein 0.0115 0.144 0.3405
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0713 0.1156
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0193 0.0611
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0034 0.0241 0.1528
Echinococcus granulosus citrate lyase subunit beta protein 0.0025 0.0107 0.0165
Loa Loa (eye worm) hypothetical protein 0.0114 0.1426 0.1613
Entamoeba histolytica hypothetical protein 0.0115 0.144 0.3405
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.027 0.069
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0241 0.0258

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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