Detailed information for compound 1074648

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 444.996 | Formula: C28H29ClN2O
  • H donors: 1 H acceptors: 1 LogP: 6.8 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCC(c1ccc2c(c1)cccc2)NC(=O)c1cccc(c1)c1ccccc1)C.Cl
  • InChi: 1S/C28H28N2O.ClH/c1-30(2)18-17-27(25-16-15-22-11-6-7-12-23(22)19-25)29-28(31)26-14-8-13-24(20-26)21-9-4-3-5-10-21;/h3-16,19-20,27H,17-18H2,1-2H3,(H,29,31);1H
  • InChiKey: ZBFDXTROOCDLCJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens urotensin 2 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0262 0.3593 0.9983
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0014 0.0043 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0246 0.0619
Echinococcus granulosus smad 0.0018 0.0099 0.0098
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0014 0.0043 0.0633
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.0043 0.0633
Brugia malayi Pip kinase protein 1 0.0014 0.0043 0.0121
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0014 0.0043 0.0043
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.0014 0.0043 0.0633
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0246 0.0619
Loa Loa (eye worm) hypothetical protein 0.0081 0.0994 0.276
Trypanosoma brucei ISWI complex protein 0.0013 0.003 0.0277
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.024 0.2264
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0409 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0032 0.0301 0.03
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0994 0.5
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0001 0.0002
Brugia malayi MH1 domain containing protein 0.0018 0.0099 0.0275
Plasmodium falciparum zinc finger protein, putative 0.0015 0.0053 0.0347
Loa Loa (eye worm) pip kinase 1 0.0014 0.0043 0.0119
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0001 0.0001
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0014 0.0043 0.004
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0133 0.2938
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0608 0.1689
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0409 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0169 0.1538
Brugia malayi nuclear receptor NHR-88 0.0011 0.0001 0.0002
Entamoeba histolytica phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.0043 0.0064
Loa Loa (eye worm) CXXC zinc finger family protein 0.0124 0.1619 0.4498
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0175 0.234 0.234
Brugia malayi MH2 domain containing protein 0.0018 0.0099 0.0275
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0126 0.1646 0.4572
Schistosoma mansoni myst-related protein 0.0015 0.0053 0.0053
Brugia malayi hypothetical protein 0.0262 0.3593 0.9983
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.004 0.0409 0.0409
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0409 1
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0409 0.1137
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0409 0.1135
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0246 0.0619
Brugia malayi nuclear hormone receptor 0.0011 0.0001 0.0002
Echinococcus granulosus survival motor neuron protein 1 0.0262 0.3593 0.3593
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0133 0.0799
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0133 0.251
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0409 0.0409
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0001 0.0002
Echinococcus multilocularis cpg binding protein 0.0131 0.1721 0.172
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0133 0.0133
Schistosoma mansoni cpg binding protein 0.0124 0.1619 0.1619
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0409 0.1137
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0014 0.0043 0.0043
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0214 0.0594
Loa Loa (eye worm) hypothetical protein 0.004 0.0409 0.1135
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.0598 1
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0093 0.0763
Schistosoma mansoni myst-related protein 0.0015 0.0053 0.0053
Giardia lamblia Hypothetical protein 0.0014 0.0043 0.0633
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0994 0.3042
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0001 0.0002
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0255 0.6049
Schistosoma mansoni ferritin light chain 0.0017 0.0093 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0246 0.0619
Echinococcus multilocularis dna polymerase eta 0.004 0.0409 0.0408
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.0043 0.0633
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0409 1
Onchocerca volvulus Huntingtin homolog 0.0126 0.1646 0.4676
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0409 1
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0014 0.0043 0.0043
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0014 0.0043 0.004
Toxoplasma gondii exonuclease III APE 0.002 0.0133 0.0358
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0014 0.0043 0.0633
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0409 0.0408
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.004 0.0409 0.0409
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0409 0.4003
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0133 0.0298
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.024 0.1626
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0081 0.0994 0.0993
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0014 0.0043 0.0633
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.034 0.1003
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0099 0.0273
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.0043 0.0633
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0001 0.0001
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0175 0.234 0.234
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase type II beta, putative 0.0014 0.0043 0.0633
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0001 0.0002
Schistosoma mansoni apoferritin-2 0.0017 0.0093 0.0093
Onchocerca volvulus 0.0035 0.034 0.0967
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0265 0.3628 0.3628
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0041 0.0033
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0091 0.0224
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0001 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0001 0.0002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0246 0.0619
Schistosoma mansoni survival motor neuron protein 0.0054 0.0608 0.0608
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0001 0.0001
Brugia malayi Probable ClpP-like protease 0.0081 0.0994 0.2761
Entamoeba histolytica phosphoinositide kinase, putative 0.0014 0.0043 0.0064
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0014 0.0043 0.0121
Echinococcus granulosus ferritin 0.0017 0.0093 0.0092
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0133 0.2938
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0409 1
Trypanosoma brucei unspecified product 0.0027 0.0233 0.55
Schistosoma mansoni smad1 5 8 and 0.0018 0.0099 0.0099
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0255 0.2422
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0099 0.0098
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.005
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0014 0.0043 0.0043
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0246 0.0619
Onchocerca volvulus 0.0175 0.234 0.6646
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0001 0.0001
Schistosoma mansoni ferritin 0.0017 0.0093 0.0093
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.0598 1
Echinococcus granulosus Smad4 0.0018 0.0099 0.0098
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0214 0.0528
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0001 0.0002
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0133 0.2938
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0246 0.0619
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0994 1
Onchocerca volvulus 0.0011 0.0001 0.0002
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0409 1
Echinococcus multilocularis smad 0.0018 0.0099 0.0098
Onchocerca volvulus Huntingtin homolog 0.0126 0.1646 0.4676
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0001 0.0001
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0028 0.0027
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0115 0.0115
Trypanosoma brucei unspecified product 0.004 0.0409 1
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.0014 0.0043 0.0633
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0014 0.0043 0.0043
Toxoplasma gondii hypothetical protein 0.0028 0.024 0.0689
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0409 0.6266
Loa Loa (eye worm) hypothetical protein 0.0175 0.234 0.65
Leishmania major DNA polymerase kappa, putative 0.004 0.0409 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0001 0.0002
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0133 0.0298
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0233 0.55
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0059 0.0084
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0255 0.2422
Schistosoma mansoni ap endonuclease 0.002 0.0133 0.0133
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0175 0.234 0.2339
Loa Loa (eye worm) histone methyltransferase 0.004 0.0409 0.1136
Brugia malayi hypothetical protein 0.0019 0.0109 0.0303
Schistosoma mansoni hypothetical protein 0.0013 0.0028 0.0028
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0014 0.0043 0.0077
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0409 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0409 1
Schistosoma mansoni DNA polymerase eta 0.004 0.0409 0.0409
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0409 1
Onchocerca volvulus 0.0124 0.1619 0.46
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0994 1
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0409 0.1087
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0041 0.0572
Brugia malayi ecdysteroid receptor 0.0011 0.0001 0.0002
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0014 0.0043 0.0077
Brugia malayi polk-prov protein 0.0012 0.0019 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0001 0.0002
Entamoeba histolytica hypothetical protein 0.0015 0.0053 0.0313
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.0043 0.0633
Schistosoma mansoni ferritin 0.0017 0.0093 0.0093
Onchocerca volvulus 0.0054 0.0608 0.1727
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0226 0.3079 0.8553
Brugia malayi Pre-SET motif family protein 0.0035 0.034 0.0946
Echinococcus multilocularis ferritin 0.0017 0.0093 0.0092
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.034 0.034
Schistosoma mansoni coup transcription factor 0.0011 0.0001 0.0001
Echinococcus granulosus dna polymerase kappa 0.004 0.0409 0.0408
Echinococcus granulosus bloom syndrome protein 0.0026 0.0214 0.0213
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0255 0.2422
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.0598 0.0597
Brugia malayi CXXC zinc finger family protein 0.0124 0.1619 0.4499
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.00000000018075
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0028 0.0027
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0133 0.0448
Echinococcus granulosus expressed protein 0.0017 0.0093 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0001 0.0002
Schistosoma mansoni ferritin 0.0017 0.0093 0.0093
Schistosoma mansoni apoferritin-2 0.0017 0.0093 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0409 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.034 0.034
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.034 0.034
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0001 0.0001
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0255 0.6049
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0081 0.0994 0.0993
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0041 0.0572
Loa Loa (eye worm) RecQ helicase 0.0026 0.0214 0.0592
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0133 0.0448
Brugia malayi MH2 domain containing protein 0.0018 0.0099 0.0275
Brugia malayi Smad1 0.0018 0.0099 0.0275
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0409 1
Brugia malayi Pip kinase protein 2 0.0175 0.234 0.65
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0409 0.6266
Giardia lamblia DINP protein human, muc B family 0.004 0.0409 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0246 0.0619
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0136 0.0136
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0246 0.0619
Trypanosoma cruzi phosphatidylinositol 4-phosphate 5-kinase alpha, putative 0.0014 0.0043 0.0633
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0233 0.55
Plasmodium vivax SET domain protein, putative 0.0035 0.034 0.3298
Brugia malayi hypothetical protein 0.0126 0.1646 0.4573
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0214 0.0528
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0032 0.0301 0.03
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0409 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0081 0.0994 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0255 0.0706
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0994 0.3042
Trypanosoma cruzi phosphatidylinositol (3,5) kinase, putative 0.0014 0.0043 0.0633
Schistosoma mansoni cpg binding protein 0.0131 0.1721 0.1721
Plasmodium falciparum phosphatidylinositol-4-phosphate 5-kinase 0.0014 0.0043 0.0253
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0246 0.0619
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0409 0.1087
Loa Loa (eye worm) MH2 domain-containing protein 0.0263 0.36 1
Schistosoma mansoni ferritin 0.0017 0.0093 0.0093
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0133 0.1176
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0246 0.0619
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0133 0.0371
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0994 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0001 0.0002
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0032 0.0301 0.03
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0246 0.0619
Toxoplasma gondii histone lysine methyltransferase SET1 0.0237 0.3225 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0133 0.1176
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0081 0.0994 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0255 0.6049
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0409 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0001 0.0002
Trichomonas vaginalis helicase, putative 0.0028 0.0246 0.0619
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0001 0.0001
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0994 1
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0014 0.0043 0.0043
Trypanosoma brucei unspecified product 0.0027 0.0233 0.55
Echinococcus granulosus dna polymerase eta 0.004 0.0409 0.0408
Echinococcus multilocularis Smad4 0.0018 0.0099 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0001 0.0002
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0994 1
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0409 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0081 0.0994 0.0994
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0032 0.0301 0.0301
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0032 0.0301 0.03
Leishmania major DNA polymerase eta, putative 0.004 0.0409 1
Schistosoma mansoni cpg binding protein 0.0131 0.1721 0.1721
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.0054 0.0608 0.0608
Trypanosoma cruzi ISWI complex protein 0.0013 0.003 0.0277
Schistosoma mansoni smad 0.0018 0.0099 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0246 0.0619
Giardia lamblia Phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.0043 0.0633
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.0043 0.0633
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0043 0.0253
Loa Loa (eye worm) FYVE zinc finger family protein 0.0014 0.0043 0.0119
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0409 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0133 0.1176
Brugia malayi hypothetical protein 0.0029 0.0255 0.0708
Brugia malayi MH2 domain containing protein 0.0263 0.36 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.034 0.034
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0409 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.0094 0.0768
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0409 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0001 0.0002
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0041 0.0572
Onchocerca volvulus 0.0257 0.3521 1
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0175 0.234 0.2339
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0255 0.0737
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0409 0.0409
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.0598 0.5598
Brugia malayi steroid hormone receptor 0.0011 0.0001 0.0002
Brugia malayi F/Y-rich N-terminus family protein 0.0039 0.0402 0.1118
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0246 0.0619
Schistosoma mansoni Smad4 0.0018 0.0099 0.0099
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0099 0.0099
Loa Loa (eye worm) Smad1 0.0018 0.0099 0.0273
Brugia malayi Pre-SET motif family protein 0.0226 0.3079 0.8553
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0099 0.0098
Loa Loa (eye worm) hypothetical protein 0.0131 0.1709 0.4747
Trypanosoma brucei DNA polymerase eta, putative 0.004 0.0409 1
Echinococcus multilocularis dna polymerase kappa 0.004 0.0409 0.0408
Loa Loa (eye worm) transcription factor SMAD2 0.0263 0.36 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0133 0.0133
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-kinase 0.0014 0.0043 0.0077
Echinococcus granulosus cpg binding protein 0.0131 0.1721 0.172
Leishmania major hypothetical protein, conserved 0.0029 0.0255 0.6049
Brugia malayi MH1 domain containing protein 0.0018 0.0099 0.0275
Schistosoma mansoni ferritin light chain 0.0017 0.0093 0.0093
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0099 0.0098
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.024 0.2264
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0409 1
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.024 0.1626
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0014 0.0043 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0001 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0233 0.55
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.0598 0.0597
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0059 0.0084
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.034 0.034
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.034 0.034
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.034 0.034
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0246 0.0619
Schistosoma mansoni ap endonuclease 0.002 0.0133 0.0133
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0285 0.0284
Trichomonas vaginalis ferritin, putative 0.0017 0.0093 0.0182
Schistosoma mansoni smad1 5 8 and 0.0018 0.0099 0.0099
Leishmania major phosphatidylinositol-4-phosphate-5-kinase-likep ro tein 0.0014 0.0043 0.0633
Trichomonas vaginalis set domain proteins, putative 0.0257 0.3521 1
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0001 0.0001
Loa Loa (eye worm) pip kinase 2 0.0175 0.234 0.65
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0133 0.2938
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0099 0.0273
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0409 0.0408
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0133 0.0369
Echinococcus multilocularis survival motor neuron protein 1 0.0262 0.3593 0.3593
Schistosoma mansoni smad1 5 8 and 0.0018 0.0099 0.0099
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0214 0.0213
Loa Loa (eye worm) hypothetical protein 0.0035 0.034 0.0944
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0409 1
Echinococcus multilocularis expressed protein 0.0017 0.0093 0.0092
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0001 0.0001
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0001 0.0002
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0001 0.0001
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0093 0.0763
Plasmodium vivax phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.0043 0.0253
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.0994 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0133 0.2938
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like protein 0.0014 0.0043 0.0633
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0001 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0246 0.0619
Trichomonas vaginalis hypothetical protein 0.0015 0.0059 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0246 0.0619
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0409 0.4003
Loa Loa (eye worm) hypothetical protein 0.0126 0.1646 0.4572
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0014 0.0043 0.0119
Leishmania major phosphatidylinositol (3,5) kinase, putative 0.0014 0.0043 0.0633
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0099 0.0098

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 6.27 Agonist activity against human urotensin 2 receptor expressed in human NIH373 cells assessed as beta-galactosidase activity after 5 days by R-SAT assay ChEMBL. 19481466
Efficacy (functional) = 67 % Agonist activity against human urotensin 2 receptor expressed in human NIH373 cells assessed as beta-galactosidase activity after 5 days by R-SAT assay relative to urotensin 2 ChEMBL. 19481466

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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