Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.0099 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0099 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0099 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0099 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.0099 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0099 | 0.0342 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0272 | 0.319 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0099 | 0.0933 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.0099 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.025 | 0.2882 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.022 | 0.0763 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0099 | 0.0933 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.0099 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0099 | 0.0342 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0099 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0099 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0099 | 0.0342 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0114 | 0.1058 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0099 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0099 | 0.0342 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.0099 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0099 | 0.0342 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.0099 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0099 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.022 | 0.0763 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0099 | 0.0342 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0099 | 0.0342 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0099 | 0.0342 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0099 | 0.0342 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0099 | 0.0342 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.0099 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.0099 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.1058 | 0.3672 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0099 | 0.0342 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0099 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.022 | 0.0763 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0099 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0099 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.025 | 0.2882 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0099 | 0.0342 |
Brugia malayi | MH2 domain containing protein | 0.025 | 0.2882 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.022 | 0.0763 |
Onchocerca volvulus | 0.0114 | 0.1058 | 1 | |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.0099 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 76 % | Inhibition of HIV1 recombinant protease at 50 nM after 15 mins by fluorescence assay | ChEMBL. | 19954246 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.