Detailed information for compound 1074699

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 320.345 | Formula: C18H16N4O2
  • H donors: 1 H acceptors: 4 LogP: 4.91 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=Cc1nc(Nc2ccccc2)c2c(n1)ccc(c2)[N+](=O)[O-])C
  • InChi: 1S/C18H16N4O2/c1-12(2)10-17-20-16-9-8-14(22(23)24)11-15(16)18(21-17)19-13-6-4-3-5-7-13/h3-11H,1-2H3,(H,19,20,21)
  • InChiKey: MKZIYRQYLZSVDK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis ran, putative 0.0044 0.0423 0.8828
Echinococcus granulosus Low density lipoprotein receptor class A cysteine rich 0.0015 0.0067 0.0055
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0013 0.0042 0.0622
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0131 0.1785
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1098 0.1438
Echinococcus granulosus low density lipoprotein receptor protein 0.0015 0.0067 0.0055
Brugia malayi RNA binding protein 0.0065 0.0687 0.1986
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0204 0.0193
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.014 0.0184
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0013 0.0042 0.003
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0108 0.0141
Echinococcus granulosus basement membrane specific heparan sulfate 0.0015 0.0067 0.0055
Brugia malayi hypothetical protein 0.0074 0.0794 0.2294
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0131 0.1785
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0131 0.1785
Echinococcus granulosus Smad4 0.0016 0.009 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0055 0.0507
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0131 0.1785
Schistosoma mansoni bromodomain containing protein 0.0066 0.0702 0.0691
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0192 0.1344
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0291 0.3462 0.3454
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0012 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0027 0.0307
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0365 0.7588
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0109 0.2076
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0658 0.0647
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0104 0.0136
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0112 0.0101
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.009 0.0079
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0658 1
Trypanosoma brucei ISWI complex protein 0.0015 0.0075 0.0843
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Leishmania major GTP-binding protein, putative 0.0044 0.0423 0.6279
Brugia malayi MH2 domain containing protein 0.0016 0.009 0.0261
Onchocerca volvulus 0.0015 0.0067 0.0938
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0087
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0015 0.0067 0.0087
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0065 0.0053
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0109 0.1323
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0015 0.0067 0.0055
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0327 0.0316
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0049 0.0781
Schistosoma mansoni hypothetical protein 0.0031 0.0271 0.026
Onchocerca volvulus Arrow homolog 0.0015 0.0067 0.0938
Entamoeba histolytica hypothetical protein 0.0025 0.0192 0.229
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0109 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0049 0.0781
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0365 0.1054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0687 0.0677
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0365 0.0354
Brugia malayi Cytochrome P450 family protein 0.0012 0.004 0.0116
Schistosoma mansoni hypothetical protein 0.0015 0.0075 0.0064
Schistosoma mansoni cpg binding protein 0.0063 0.0662 0.0651
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Brugia malayi G-protein alpha subunit 0.0013 0.0042 0.0121
Trichomonas vaginalis hypothetical protein 0.0011 0.0026 0.0273
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0131 0.2538
Schistosoma mansoni hypothetical protein 0.0031 0.0271 0.026
Echinococcus multilocularis dna polymerase kappa 0.002 0.0131 0.0119
Schistosoma mansoni smad1 5 8 and 0.0016 0.009 0.0079
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0109 0.2076
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0108 0.0096
Schistosoma mansoni fkbp-rapamycin associated protein 0.001 0.0013 0.0001
Loa Loa (eye worm) hypothetical protein 0.0099 0.1098 0.1438
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0065 0.0053
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0015 0.0067 0.0087
Schistosoma mansoni DNA polymerase eta 0.002 0.0131 0.0119
Onchocerca volvulus 0.0015 0.0067 0.0938
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0109 0.1421
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0192 0.018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0049 0.0781
Schistosoma mansoni hypothetical protein 0.0031 0.0271 0.026
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0291 0.3462 0.3454
Schistosoma mansoni smad1 5 8 and 0.0016 0.009 0.0079
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0011 0.0027 0.0027
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0013 0.0042 0.003
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0423 1
Loa Loa (eye worm) Smad1 0.0016 0.009 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0049 0.0781
Loa Loa (eye worm) hypothetical protein 0.007 0.0752 0.0985
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0087
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0109 0.2076
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0109 0.1233
Plasmodium vivax importin-beta 2, putative 0.0059 0.0614 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0423 0.8828
Brugia malayi Low-density lipoprotein receptor-related protein, putative 0.0015 0.0067 0.0193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0687 0.0677
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0687 0.09
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0109 0.0098
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0109 0.1421
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0017
Trypanosoma brucei cytochrome P450, putative 0.0012 0.004 0.0248
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0087
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0291 0.3462 0.3454
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0015 0.0067 0.0193
Schistosoma mansoni ran 0.0044 0.0423 0.0411
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0015 0.0067 0.0193
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0204 0.0193
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0192 0.018
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0271 0.026
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0013 0.0042 0.0622
Loa Loa (eye worm) hypothetical protein 0.002 0.0131 0.0171
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0087
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0271 0.026
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0423 0.321
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0067 0.0055
Trypanosoma brucei unspecified product 0.0014 0.0055 0.0507
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0015 0.0067 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0049 0.0781
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0049 0.0781
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0049 0.0781
Schistosoma mansoni cpg binding protein 0.0063 0.0662 0.0651
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0012 0.0034
Loa Loa (eye worm) importin-beta domain-containing protein 0.0011 0.0026 0.0033
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0131 0.2538
Brugia malayi Bromodomain containing protein 0.0078 0.0845 0.2441
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0013 0.0042 0.0622
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0108 0.0096
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0055
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0271 0.026
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0109 0.1233
Leishmania major DNA polymerase eta, putative 0.002 0.0131 0.1662
Onchocerca volvulus 0.0015 0.0067 0.0938
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0013 0.0042 0.0055
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0015 0.0067 0.0055
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0013 0.0042 0.0121
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0049 0.0781
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0097 0.0085
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0365 0.7588
Loa Loa (eye worm) hypothetical protein 0.0046 0.045 0.0589
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Brugia malayi PHD-finger family protein 0.0028 0.0233 0.0673
Plasmodium falciparum importin beta, putative 0.0059 0.0614 1
Trypanosoma cruzi ISWI complex protein 0.0015 0.0075 0.1343
Echinococcus granulosus low density lipoprotein receptor ldl 0.0015 0.0067 0.0055
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0109 0.0098
Entamoeba histolytica hypothetical protein 0.0074 0.0794 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0365 0.5
Entamoeba histolytica hypothetical protein 0.0074 0.0794 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0109 0.0316
Loa Loa (eye worm) hypothetical protein 0.0041 0.0386 0.0505
Echinococcus multilocularis smad 0.0016 0.009 0.0079
Schistosoma mansoni hypothetical protein 0.0074 0.0794 0.0783
Leishmania major hypothetical protein, conserved 0.0015 0.0075 0.0785
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0365 0.4446
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0365 0.5766
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0112 0.0101
Echinococcus granulosus zinc finger protein 0.0023 0.0168 0.0156
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0131 0.0171
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0131 0.2538
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0015 0.0067 0.0938
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0658 0.0647
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0131 0.0119
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0365 0.0478
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0013 0.0042 0.003
Schistosoma mansoni GTP-binding protein alpha subunit 0.0013 0.0042 0.003
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0013 0.0042 0.0121
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0131 0.1465
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0087
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0015
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0013 0.0042 0.003
Brugia malayi MH2 domain containing protein 0.0016 0.009 0.0261
Giardia lamblia DINP protein human, muc B family 0.002 0.0131 0.0684
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0012 0.0034
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0013 0.0042 0.003
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0109 0.1323
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0658 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.009 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0012 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0012 0.0015
Leishmania major cytochrome p450-like protein 0.0012 0.004 0.0231
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0013 0.0042 0.0622
Schistosoma mansoni GTP-binding protein alpha subunit 0.0013 0.0042 0.003
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0013 0.0042 0.003
Echinococcus granulosus geminin 0.0173 0.2017 0.2007
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0131 0.1785
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0012 0.0034
Loa Loa (eye worm) hypothetical protein 0.0038 0.0357 0.0468
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0097 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Loa Loa (eye worm) kap beta 3 protein 0.0011 0.0026 0.0033
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0013 0.0042 0.003
Schistosoma mansoni ran 0.0044 0.0423 0.0411
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0013 0.0042 0.0121
Brugia malayi Bromodomain containing protein 0.0038 0.0356 0.1029
Echinococcus multilocularis geminin 0.0173 0.2017 0.2007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Schistosoma mansoni zinc finger protein 0.0015 0.0075 0.0064
Echinococcus granulosus importin 5 0.0011 0.0026 0.0014
Brugia malayi RNA, U transporter 1 0.0168 0.1953 0.5641
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0013 0.0042 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0015
Loa Loa (eye worm) CYP4Cod1 0.0012 0.004 0.0053
Echinococcus multilocularis transportin 1 0.0011 0.0026 0.0014
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0687 0.0677
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0087
Echinococcus multilocularis dna polymerase eta 0.002 0.0131 0.0119
Echinococcus multilocularis GPCR, family 2 0.0031 0.0271 0.026
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Brugia malayi nuclear hormone receptor 0.001 0.0012 0.0034
Schistosoma mansoni hypothetical protein 0.0021 0.014 0.0129
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0055
Echinococcus granulosus low density lipoprotein receptor ldl 0.0015 0.0067 0.0055
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0109 0.0098
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0149 0.2939
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0012 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0012 0.0015
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0015 0.0067 0.0055
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0687 0.09
Brugia malayi CUB domain containing protein 0.0015 0.0067 0.0193
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0013 0.0042 0.003
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0012 0.0034
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0109 0.2076
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0291 0.3462 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0658 1
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0013 0.0042 0.003
Echinococcus granulosus serine:threonine protein kinase SMG1 0.001 0.0013 0.0001
Echinococcus granulosus snurportin 1 0.0632 0.7638 0.7635
Schistosoma mansoni hypothetical protein 0.0015 0.0067 0.0055
Brugia malayi steroid hormone receptor 0.001 0.0012 0.0034
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0097 0.0085
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0687 0.1986
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0013 0.0042 0.003
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0794 0.0783
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0013 0.0042 0.003
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.001 0.0013 0.0037
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0271 0.026
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0012 0.0034
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0131 0.1508
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0131 0.2538
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.004 0.0053
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0013 0.0042 0.003
Schistosoma mansoni zinc finger protein 0.0023 0.0168 0.0156
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0055 0.0507
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.004 0.0588
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0109 0.1323
Entamoeba histolytica hypothetical protein 0.0074 0.0794 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0271 0.0355
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0715 0.2066
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0109 0.0143
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0087
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0109 0.1323
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0013 0.0042 0.0622
Echinococcus multilocularis importin 5 0.0011 0.0026 0.0014
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0013 0.0042 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0012 0.0015
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0423 0.0411
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0015 0.0067 0.0055
Onchocerca volvulus Terribly reduced optic lobes homolog 0.0015 0.0067 0.0938
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0477 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Onchocerca volvulus 0.0013 0.0042 0.0512
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0015 0.0067 0.0055
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.009 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Echinococcus granulosus 5'partial|Low density lipoprotein receptor class A cysteine rich 0.0015 0.0067 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0012 0.0034
Brugia malayi basement membrane proteoglycan precursor 0.0015 0.0067 0.0193
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0013 0.0042 0.0121
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0291 0.3462 0.3454
Schistosoma mansoni hypothetical protein 0.0173 0.2017 0.2007
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0131 0.2538
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0013 0.0042 0.0121
Schistosoma mansoni hypothetical protein 0.0031 0.0271 0.026
Loa Loa (eye worm) hypothetical protein 0.0021 0.0149 0.0195
Loa Loa (eye worm) transcription factor SMAD2 0.0242 0.2853 0.3736
Onchocerca volvulus 0.0013 0.0042 0.0512
Schistosoma mansoni hypothetical protein 0.0067 0.0715 0.0704
Loa Loa (eye worm) hypothetical protein 0.0018 0.0112 0.0147
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0192 0.3855
Echinococcus granulosus cpg binding protein 0.0063 0.0662 0.0651
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0012 0.0015
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0049 0.0781
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0423 0.6744
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0012 0.0034
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0015 0.0067 0.0193
Leishmania major importin beta-1 subunit, putative 0.0048 0.0477 0.7139
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0658 0.0647
Brugia malayi nuclear receptor NHR-88 0.001 0.0012 0.0034
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.009 0.0079
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.004 0.0053
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0015 0.0067 0.0055
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0131 0.0119
Echinococcus granulosus GPCR family 2 0.0031 0.0271 0.026
Schistosoma mansoni ap endonuclease 0.0039 0.0365 0.0354
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0012 0.0034
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0131 0.0377
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0658 0.0647
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0055 0.0507
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0109 0.0143
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0013 0.0042 0.0121
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0109 0.0098
Echinococcus granulosus dna polymerase kappa 0.002 0.0131 0.0119
Loa Loa (eye worm) hypothetical protein 0.0067 0.0715 0.0936
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0011 0.0027 0.0013
Brugia malayi ecdysteroid receptor 0.001 0.0012 0.0034
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0015 0.0067 0.0193
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0015 0.0067 0.0193
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0065 0.0053
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0365 0.5259
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0015
Onchocerca volvulus 0.0015 0.0067 0.0938
Brugia malayi Calcium binding EGF domain containing protein 0.0015 0.0067 0.0193
Entamoeba histolytica hypothetical protein 0.0074 0.0794 1
Echinococcus multilocularis Smad4 0.0016 0.009 0.0079
Trichomonas vaginalis helicase, putative 0.0013 0.0049 0.0781
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0049 0.0781
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0012 0.0034
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0013 0.0042 0.0055
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0012 0.0015
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0013 0.0042 0.003
Schistosoma mansoni importin-beta 2 0.0011 0.0026 0.0014
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0477 1
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0128 0.0371
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0632 0.7638 1
Brugia malayi enteropeptidase precursor 0.0015 0.0067 0.0193
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0658 1
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0687 0.0677
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0614 1
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0015 0.0067 0.0055
Schistosoma mansoni hypothetical protein 0.0173 0.2017 0.2007
Echinococcus granulosus basement membrane specific heparan sulfate 0.0015 0.0067 0.0055
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0015 0.0067 0.0193
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0015
Onchocerca volvulus 0.0013 0.0042 0.0512
Schistosoma mansoni smad 0.0016 0.009 0.0079
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0109 0.1421
Entamoeba histolytica G protein alpha subunit, putative 0.0013 0.0042 0.037
Echinococcus multilocularis expressed protein 0.0013 0.0042 0.003
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.001 0.0013 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0131 0.1785
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0365 0.8163
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.1394 0.1384
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0012 0.0034
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0049 0.0781
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.009 0.0079
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0658 0.0647
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0065 0.0053
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0015 0.0067 0.0193
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0658 0.5112
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0291 0.3462 0.3454
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0013 0.0042 0.0121
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0131 0.1785
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0013 0.0042 0.003
Leishmania major DNA polymerase kappa, putative 0.002 0.0131 0.1662
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0097 0.0085
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0055
Brugia malayi Smad1 0.0016 0.009 0.0261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0365 0.4508
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0423 0.6744
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0049 0.0781
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0112 0.0101
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0477 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0365 0.0354
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0365 0.7588
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0012 0.0034
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0013 0.0042 0.003
Schistosoma mansoni importin beta-1 0.0059 0.0614 0.0603
Schistosoma mansoni smad1 5 8 and 0.0016 0.009 0.0079
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0012 0.0034
Brugia malayi TAR-binding protein 0.0065 0.0687 0.1986
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0131 0.1785
Brugia malayi Importin beta-1 subunit 0.0059 0.0614 0.1774
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0192 0.018
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0013 0.0042 0.003
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0291 0.3462 0.4532
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0192 0.0554
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0012 0.0015
Toxoplasma gondii histone lysine methyltransferase SET1 0.0112 0.1262 1
Echinococcus granulosus transportin 1 0.0011 0.0026 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0131 0.1785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0291 0.3462 0.3454
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0614 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0687 0.0677
Loa Loa (eye worm) MH2 domain-containing protein 0.0242 0.2853 0.3736
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0131 0.2538
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0049 0.0781
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0423 0.8828
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0013 0.0042 0.003
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0192 0.2824
Echinococcus granulosus expressed protein 0.0013 0.0042 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0365 0.7588
Schistosoma mansoni cpg binding protein 0.0058 0.0598 0.0587
Echinococcus multilocularis cpg binding protein 0.0063 0.0662 0.0651
Loa Loa (eye worm) hypothetical protein 0.0059 0.0614 0.0804
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0109 0.0677
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0015
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0131 0.0119
Brugia malayi MH1 domain containing protein 0.0016 0.009 0.0261
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0013 0.0042 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0027 0.0307
Trypanosoma brucei unspecified product 0.002 0.0131 0.1785
Echinococcus multilocularis translational activator gcn1 0.0011 0.0026 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0131 0.1785
Schistosoma mansoni hypothetical protein 0.0632 0.7638 0.7635
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0087
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0036
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0013 0.0042 0.0055
Entamoeba histolytica Ran family GTPase 0.0044 0.0423 0.5244
Echinococcus granulosus dna polymerase eta 0.002 0.0131 0.0119
Trypanosoma brucei unspecified product 0.0014 0.0055 0.0507
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1098 0.3172
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.011 0.133
Entamoeba histolytica HEAT repeat domain containing protein 0.0011 0.0026 0.0162
Brugia malayi kap beta 3 protein 0.0011 0.0026 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0109 0.0098
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0131 0.2538
Brugia malayi Cytochrome P450 family protein 0.0012 0.004 0.0116
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0794 0.0783
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0365 0.5369
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0013 0.0042 0.003
Toxoplasma gondii exonuclease III APE 0.0039 0.0365 0.2745
Schistosoma mansoni hypothetical protein 0.0015 0.0067 0.0055
Echinococcus granulosus importin subunit beta 1 0.0059 0.0614 0.0603
Loa Loa (eye worm) G protein alpha subunit 3 0.0013 0.0042 0.0055
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0327 0.0316
Brugia malayi MH1 domain containing protein 0.0016 0.009 0.0261
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0423 0.1221
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0365 0.5766
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.004 0.0588
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0049 0.0781
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0794 0.0783
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.0015 0.0067 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0271 0.0783
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0109 0.2076
Schistosoma mansoni Smad4 0.0016 0.009 0.0079
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0131 0.0119
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0087
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.009 0.0079
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0087
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.011 0.2086
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0131 0.1662
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0365 0.5766
Echinococcus multilocularis snurportin 1 0.0632 0.7638 0.7635
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0087
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0055
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0049 0.0781
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0291 0.3462 0.3454
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0109 0.1421
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0271 0.0355
Loa Loa (eye worm) RNA binding protein 0.0065 0.0687 0.09
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.009 0.0118
Echinococcus multilocularis zinc finger protein 0.0023 0.0168 0.0156
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0131 0.1785
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0055
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0423 0.6744
Brugia malayi MH2 domain containing protein 0.0242 0.2853 0.8243
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0271 0.0783
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0015 0.0067 0.0055
Echinococcus granulosus translational activator gcn1 0.0011 0.0026 0.0014
Brugia malayi hypothetical protein 0.0013 0.0042 0.0121
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0109 0.0316
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0013 0.0042 0.0622
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0477 1
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0131 0.1785
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1098 0.3172
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0015 0.0067 0.0193
Echinococcus granulosus tar DNA binding protein 0.0065 0.0687 0.0677
Schistosoma mansoni ap endonuclease 0.0039 0.0365 0.0354
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0013 0.0042 0.0121
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0131 0.0377
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0112 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0192 0.3855
Onchocerca volvulus 0.0058 0.0598 1
Onchocerca volvulus 0.0015 0.0067 0.0938
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0131 0.1465
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0012 0.0034
Echinococcus multilocularis importin subunit beta 1 0.0059 0.0614 0.0603
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0013 0.0042 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0131 0.1785
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0109 0.1323
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0423 0.0553
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0658 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0687 0.0677
Echinococcus multilocularis low density lipoprotein receptor protein 0.0015 0.0067 0.0055
Brugia malayi CXXC zinc finger family protein 0.0058 0.0598 0.1728
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Entamoeba histolytica hypothetical protein 0.0048 0.0477 0.594
Onchocerca volvulus 0.0015 0.0067 0.0938
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0013 0.0042 0.0622
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0049 0.0781
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0013 0.0042 0.0622
Trypanosoma cruzi ISWI complex protein 0.0015 0.0075 0.1343
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0015 0.0067 0.0055
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0015 0.0067 0.0087
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0365 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0012 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0013 0.0042 0.0121
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0065 0.0053
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.0614 0.476
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0658 0.0647
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0015 0.0067 0.0087
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0015
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0109 0.1421
Echinococcus granulosus smad 0.0016 0.009 0.0079
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0015
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0423 0.0411
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0049 0.0781
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0109 0.2076
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0012 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0131 0.1785
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0204 0.0193
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0598 0.0783

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 17 microM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocyte after 48 hrs by flow cytometry ChEMBL. 19926173
IC50 (ADMET) = 50 microM Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay ChEMBL. 19926173
IC50 (functional) > 125 microM Cytotoxicity against human K562 cells after 72 hrs by flow cytometry ChEMBL. 19926173

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 19926173

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.