Detailed information for compound 1074902

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 473.434 | Formula: C19H24INOS2
  • H donors: 1 H acceptors: 1 LogP: 5.09 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CSCc1c(C)[nH]c(=O)c(c1Sc1cc(C)cc(c1)C)I)C
  • InChi: 1S/C19H24INOS2/c1-11(2)9-23-10-16-14(5)21-19(22)17(20)18(16)24-15-7-12(3)6-13(4)8-15/h6-8,11H,9-10H2,1-5H3,(H,21,22)
  • InChiKey: MFTFEEWGJABELS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0113 0.0254
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0669 0.1607
Giardia lamblia GTOR 0.0095 0.0669 0.5
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0126 0.0939 0.6413
Mycobacterium tuberculosis Probable esterase LipL 0.0181 0.1423 0.1362
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.014 0.0648
Echinococcus multilocularis expressed protein 0.0027 0.0071 0.033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0455 0.1085
Schistosoma mansoni hypothetical protein 0.0071 0.0456 0.2106
Plasmodium vivax SET domain protein, putative 0.0061 0.0373 0.0902
Schistosoma mansoni chromobox protein 0.0076 0.0503 0.2322
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0237 0.0555
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0032 0.0113 0.0521
Schistosoma mansoni smad1 5 8 and 0.0024 0.0044 0.0202
Loa Loa (eye worm) hypothetical protein 0.0181 0.1423 0.3948
Loa Loa (eye worm) glutathione reductase 0.005 0.0268 0.0738
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0311 0.0856
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0032 0.0113 0.0521
Loa Loa (eye worm) hypothetical protein 0.0181 0.1423 0.3948
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0113 0.0254
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0498 0.119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0498 0.119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0498 0.119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0113 0.0254
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0181 0.1423 1
Mycobacterium tuberculosis Conserved protein 0.0181 0.1423 0.1362
Schistosoma mansoni hypothetical protein 0.0033 0.0121 0.0558
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0095 0.0669 0.309
Schistosoma mansoni ferritin light chain 0.0027 0.0071 0.033
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0344 0.159
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0098 0.0218
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0078 0.0519 0.2395
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0045 0.0228 0.0879
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0181 0.1423 0.657
Mycobacterium ulcerans beta-lactamase 0.0181 0.1423 1
Plasmodium falciparum thioredoxin reductase 0.005 0.0268 0.5
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0268 0.1239
Echinococcus granulosus Smad4 0.0024 0.0044 0.0202
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0044 0.0202
Loa Loa (eye worm) hypothetical protein 0.0054 0.0311 0.0856
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0455 0.1085
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0373 0.2573
Trypanosoma cruzi hypothetical protein, conserved 0.0181 0.1423 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0044 0.0202
Echinococcus multilocularis GPCR, family 2 0.0033 0.0121 0.0558
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.004 0.018 0.0511
Loa Loa (eye worm) hypothetical protein 0.0181 0.1423 0.3948
Schistosoma mansoni tar DNA-binding protein 0.0265 0.2167 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0208 0.0571
Schistosoma mansoni lamin 0.0054 0.0311 0.1434
Brugia malayi MH2 domain containing protein 0.0354 0.2941 0.8144
Brugia malayi TAR-binding protein 0.0265 0.2167 0.5967
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0126 0.0939 0.0873
Echinococcus granulosus ferritin 0.0027 0.0071 0.033
Echinococcus multilocularis lamin dm0 0.0054 0.0311 0.1434
Mycobacterium tuberculosis Probable lipase LipE 0.0181 0.1423 0.1362
Loa Loa (eye worm) hypothetical protein 0.0078 0.0519 0.1435
Schistosoma mansoni Smad4 0.0024 0.0044 0.0202
Brugia malayi intermediate filament protein 0.0054 0.0311 0.0751
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0265 0.2167 0.6013
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0025 0.0118
Loa Loa (eye worm) hypothetical protein 0.0181 0.1423 0.3948
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0181 0.1423 0.3948
Brugia malayi RNA binding protein 0.0265 0.2167 0.5967
Echinococcus multilocularis Smad4 0.0024 0.0044 0.0202
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0044 0.0202
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0113 0.0194
Schistosoma mansoni apoferritin-2 0.0027 0.0071 0.033
Loa Loa (eye worm) phosphatidylinositol 3 0.0032 0.0113 0.0306
Onchocerca volvulus 0.0181 0.1423 0.3245
Echinococcus granulosus beta LACTamase domain containing family member 0.0181 0.1423 0.657
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.0827 0.0761
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0095 0.0669 0.4247
Schistosoma mansoni hypothetical protein 0.002 0.0009 0.0042
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0268 0.0198
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0373 0.172
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0268 0.0738
Loa Loa (eye worm) hypothetical protein 0.0042 0.0198 0.0543
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0327 0.0775
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0332 0.0787
Echinococcus multilocularis tar DNA binding protein 0.0265 0.2167 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0095 0.0669 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0669 0.1607
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0025 0.0118
Trichomonas vaginalis ferritin, putative 0.0027 0.0071 0.0153
Brugia malayi Heterochromatin protein 1 0.0076 0.0503 0.1291
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0121 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0547 0.1309
Loa Loa (eye worm) hypothetical protein 0.0071 0.0456 0.1261
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0078 0.0519 0.2395
Schistosoma mansoni hypothetical protein 0.0033 0.0121 0.0558
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0503 0.1202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0284 0.067
Leishmania major hypothetical protein, conserved 0.0181 0.1423 1
Brugia malayi beta-lactamase family protein 0.0181 0.1423 0.3878
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.0827 0.0761
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0074 0.0482 0.2227
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0095 0.0669 0.4247
Loa Loa (eye worm) hypothetical protein 0.0037 0.0161 0.0441
Trichomonas vaginalis set domain proteins, putative 0.0488 0.4122 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0181 0.1423 0.1362
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0121 0.0217
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.0827 0.5592
Loa Loa (eye worm) RNA binding protein 0.0265 0.2167 0.6013
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0088 0.0126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0376 0.0893
Loa Loa (eye worm) hypothetical protein 0.004 0.0182 0.0497
Toxoplasma gondii thioredoxin reductase 0.005 0.0268 0.1837
Mycobacterium tuberculosis Conserved protein 0.0181 0.1423 0.1362
Mycobacterium ulcerans lipase LipD 0.0181 0.1423 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0121 0.0329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0113 0.0254
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0332 0.0787
Loa Loa (eye worm) Smad1 0.0024 0.0044 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0057 0.0117
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0181 0.1423 0.3878
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0032 0.0113 0.0521
Mycobacterium tuberculosis Probable oxidoreductase 0.0126 0.0939 0.0873
Loa Loa (eye worm) hypothetical protein 0.0181 0.1423 0.3948
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0456 0.116
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0208 0.0485
Echinococcus granulosus tar DNA binding protein 0.0265 0.2167 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0078 0.0519 0.2395
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0076 0.0499 0.2945
Echinococcus multilocularis beta LACTamase domain containing family member 0.0181 0.1423 0.657
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0284 0.067
Trichomonas vaginalis D-aminoacylase, putative 0.0181 0.1423 0.344
Echinococcus granulosus chromobox protein 1 0.0076 0.0503 0.2322
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0268 0.1187
Mycobacterium leprae conserved hypothetical protein 0.0181 0.1423 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0063 0.0291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0283 0.0669
Schistosoma mansoni smad 0.0024 0.0044 0.0202
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0121 0.0558
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0126 0.0939 0.0873
Brugia malayi beta-lactamase 0.0181 0.1423 0.3878
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0455 0.1085
Echinococcus granulosus lamin 0.0054 0.0311 0.1434
Schistosoma mansoni apoferritin-2 0.0027 0.0071 0.033
Echinococcus granulosus chromobox protein 1 0.0076 0.0503 0.2322
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0016
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0121 0.0558
Treponema pallidum bacterioferrin (TpF1) 0.0027 0.0071 0.5
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0237 0.0275
Brugia malayi RNA recognition motif domain containing protein 0.0265 0.2167 0.5967
Mycobacterium tuberculosis Probable lipase LipD 0.0181 0.1423 0.1362
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0455 0.1085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0498 0.119
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0076 0.0499 0.2945
Schistosoma mansoni ferritin 0.0027 0.0071 0.033
Loa Loa (eye worm) TAR-binding protein 0.0265 0.2167 0.6013
Brugia malayi chromobox protein homolog 3 0.0043 0.0208 0.0462
Onchocerca volvulus 0.0488 0.4122 1
Schistosoma mansoni chromobox protein 0.0076 0.0503 0.2322
Schistosoma mansoni ferritin 0.0027 0.0071 0.033
Schistosoma mansoni ferritin light chain 0.0027 0.0071 0.033
Echinococcus multilocularis ferritin 0.0027 0.0071 0.033
Loa Loa (eye worm) hypothetical protein 0.0069 0.0439 0.1213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0455 0.1085
Brugia malayi glutathione reductase 0.005 0.0268 0.0631
Echinococcus multilocularis chromobox protein 1 0.0076 0.0503 0.2322
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0208 0.0485
Onchocerca volvulus 0.0181 0.1423 0.3245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0394 0.0937
Plasmodium falciparum glutathione reductase 0.005 0.0268 0.5
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.0827 0.0761
Loa Loa (eye worm) MH2 domain-containing protein 0.0354 0.2941 0.8165
Echinococcus granulosus GPCR family 2 0.0033 0.0121 0.0558
Trypanosoma brucei trypanothione reductase 0.005 0.0268 0.1187
Schistosoma mansoni tar DNA-binding protein 0.0265 0.2167 1
Schistosoma mansoni tar DNA-binding protein 0.0265 0.2167 1
Plasmodium vivax hypothetical protein, conserved 0.0181 0.1423 1
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0237 0.0555
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.0827 0.0761
Echinococcus granulosus intermediate filament protein 0.0054 0.0311 0.1434
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0113 0.0254
Echinococcus granulosus lamin dm0 0.0054 0.0311 0.1434
Mycobacterium ulcerans hypothetical protein 0.0181 0.1423 1
Brugia malayi PHD-finger family protein 0.0024 0.0046 0.0006
Onchocerca volvulus 0.0054 0.0311 0.046
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0344 0.159
Loa Loa (eye worm) heterochromatin protein 1 0.0076 0.0503 0.1391
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0095 0.0669 0.4247
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0095 0.0669 0.309
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0503 0.1202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0455 0.1085
Toxoplasma gondii ABC1 family protein 0.0181 0.1423 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0745 0.2064
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0044 0.0114
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0745 0.1972
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0181 0.1423 0.1362
Echinococcus multilocularis smad 0.0024 0.0044 0.0202
Brugia malayi Bromodomain containing protein 0.0073 0.0476 0.1214
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0044 0.0202
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0745 0.2064
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0088 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0498 0.119
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0121 0.0329
Trichomonas vaginalis penicillin-binding protein, putative 0.0181 0.1423 0.344
Onchocerca volvulus 0.0074 0.0482 0.089
Loa Loa (eye worm) beta-lactamase 0.0181 0.1423 0.3948
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0455 0.1085
Brugia malayi Pre-SET motif family protein 0.0429 0.3601 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0302 0.0832
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0311 0.0856
Mycobacterium tuberculosis Probable hydrolase 0.0181 0.1423 0.1362
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0284 0.067
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0095 0.0669 0.4247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0283 0.0669
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0311 0.0751
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0284 0.067
Leishmania major trypanothione reductase 0.005 0.0268 0.1187
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0095 0.0669 0.4247
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0098 0.0218
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0429 0.3601 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0121 0.0558
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0181 0.1423 0.1362
Loa Loa (eye worm) hypothetical protein 0.0181 0.1423 0.3948
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0044 0.0202
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0095 0.0669 0.1759
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0669 0.1607
Loa Loa (eye worm) hypothetical protein 0.0025 0.0054 0.0144
Loa Loa (eye worm) hypothetical protein 0.0025 0.0054 0.0144
Trichomonas vaginalis D-aminoacylase, putative 0.0181 0.1423 0.344
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0009 0.0018
Trichomonas vaginalis penicillin-binding protein, putative 0.0181 0.1423 0.344
Echinococcus multilocularis chromobox protein 1 0.0076 0.0503 0.2322
Echinococcus multilocularis musashi 0.0054 0.0311 0.1434
Onchocerca volvulus 0.0181 0.1423 0.3245
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0063 0.0291
Echinococcus multilocularis lamin 0.0054 0.0311 0.1434
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0025 0.0118
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.0827 0.0761
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0373 0.172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0283 0.0669
Echinococcus granulosus expressed protein 0.0027 0.0071 0.033
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0208 0.0203
Echinococcus granulosus histone lysine methyltransferase setb 0.0078 0.0519 0.2395
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0095 0.0669 0.4247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0332 0.0787
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0121 0.0558
Trichomonas vaginalis D-aminoacylase, putative 0.0181 0.1423 0.344
Loa Loa (eye worm) phosphatidylinositol 3 0.0095 0.0669 0.1853
Trichomonas vaginalis esterase, putative 0.0181 0.1423 0.344
Schistosoma mansoni bromodomain containing protein 0.0062 0.0375 0.1731
Schistosoma mansoni ferritin 0.0027 0.0071 0.033
Schistosoma mansoni intermediate filament proteins 0.0054 0.0311 0.1434
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0353 0.1628
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0181 0.1423 0.657
Brugia malayi Bromodomain containing protein 0.0037 0.0161 0.0329
Loa Loa (eye worm) transcription factor SMAD2 0.0354 0.2941 0.8165
Mycobacterium leprae Probable lipase LipE 0.0181 0.1423 1
Trypanosoma brucei hypothetical protein, conserved 0.0181 0.1423 1
Echinococcus granulosus smad 0.0024 0.0044 0.0202
Schistosoma mansoni smad1 5 8 and 0.0024 0.0044 0.0202
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0095 0.0669 0.5
Onchocerca volvulus 0.0054 0.0311 0.046
Loa Loa (eye worm) hypothetical protein 0.0034 0.0127 0.0345
Toxoplasma gondii target of rapamycin (TOR), putative 0.0071 0.0455 0.3155
Schistosoma mansoni tar DNA-binding protein 0.0265 0.2167 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0268 0.1239
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0095 0.0669 0.309
Schistosoma mansoni ferritin 0.0027 0.0071 0.033
Brugia malayi Pre-SET motif family protein 0.0061 0.0373 0.0924
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.014 0.0648
Trypanosoma cruzi target of rapamycin kinase 3 0.0076 0.0499 0.2945
Mycobacterium ulcerans esterase/lipase LipP 0.0181 0.1423 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0044 0.0114
Schistosoma mansoni hypothetical protein 0.0033 0.0121 0.0558
Mycobacterium tuberculosis Conserved protein 0.0181 0.1423 0.1362
Brugia malayi beta-lactamase family protein 0.0181 0.1423 0.3878
Schistosoma mansoni smad1 5 8 and 0.0024 0.0044 0.0202
Schistosoma mansoni lamin 0.0054 0.0311 0.1434
Schistosoma mansoni tar DNA-binding protein 0.0265 0.2167 1
Mycobacterium tuberculosis Probable reductase 0.0113 0.0827 0.0761
Brugia malayi Thioredoxin reductase 0.005 0.0268 0.0631
Schistosoma mansoni hypothetical protein 0.0033 0.0121 0.0558
Trypanosoma cruzi hypothetical protein, conserved 0.0181 0.1423 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0327 0.0775
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0027 0.0071 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0745 0.1972

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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