Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0032 | 0.0249 | 0.6246 |
Brugia malayi | AMP-binding enzyme family protein | 0.0073 | 0.0853 | 0.1673 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0073 | 0.0853 | 0.4448 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.2285 | 0.2283 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0032 | 0.0249 | 0.6246 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0081 | 0.0969 | 0.1901 |
Entamoeba histolytica | hypothetical protein | 0.0146 | 0.1914 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0295 | 0.0293 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.0398 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0152 | 0.3804 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0185 | 0.0183 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0398 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0073 | 0.0853 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0042 | 0.0398 | 0.1783 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0052 | 0.054 | 0.3038 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0091 | 0.1114 | 0.2187 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0039 | 0.0362 | 0.0824 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0228 | 0.2652 |
Onchocerca volvulus | 0.0027 | 0.0185 | 0.0269 | |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0152 | 0.1095 |
Entamoeba histolytica | long-chain-fatty-acid--CoA ligase, putative | 0.0021 | 0.0099 | 0.051 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0398 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.1057 | 0.2074 |
Brugia malayi | hypothetical protein | 0.0087 | 0.1057 | 0.2074 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0152 | 0.3804 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0021 | 0.0099 | 0.0552 |
Mycobacterium tuberculosis | Possible toxin MazF5 | 0.0136 | 0.1772 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0021 | 0.0099 | 0.0195 |
Brugia malayi | RNA binding protein | 0.0063 | 0.0704 | 0.1382 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0055 | 0.0583 | 0.5 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0025 | 0.0148 | 0.0146 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.0398 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0185 | 0.0183 |
Echinococcus granulosus | GPCR family 2 | 0.0081 | 0.0969 | 0.0967 |
Mycobacterium tuberculosis | Toxin MazF6 | 0.0136 | 0.1772 | 1 |
Onchocerca volvulus | 0.0042 | 0.0396 | 0.0929 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0704 | 0.0703 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0969 | 0.0967 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0042 | 0.0396 | 0.0394 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0152 | 0.0299 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0398 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0021 | 0.0099 | 0.0552 |
Brugia malayi | hypothetical protein | 0.0146 | 0.1914 | 0.3757 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0029 | 0.0207 | 0.8365 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0583 | 0.1144 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0021 | 0.01 | 0.0555 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0055 | 0.0583 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0152 | 0.3804 |
Echinococcus multilocularis | peregrin | 0.0029 | 0.0207 | 0.0205 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0021 | 0.0099 | 0.2467 |
Echinococcus granulosus | lamin | 0.0027 | 0.0185 | 0.0183 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0029 | 0.0207 | 0.0205 |
Brugia malayi | chromobox protein homolog 3 | 0.0039 | 0.0362 | 0.0711 |
Echinococcus granulosus | peregrin | 0.0029 | 0.0207 | 0.0205 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0228 | 0.0447 |
Brugia malayi | PHD-finger family protein | 0.0029 | 0.0207 | 0.0406 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.0704 | 0.0703 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0583 | 0.1144 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0021 | 0.0099 | 0.0098 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0021 | 0.0099 | 0.0552 |
Brugia malayi | AMP-binding enzyme family protein | 0.0073 | 0.0853 | 0.1673 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0178 | 0.0349 |
Loa Loa (eye worm) | hypothetical protein | 0.0256 | 0.3523 | 0.6915 |
Echinococcus multilocularis | tumor protein p63 | 0.0342 | 0.4781 | 0.478 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0035 | 0.0295 | 0.0293 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0398 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0969 | 0.0967 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.0194 | 0.0297 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0025 | 0.0148 | 0.0291 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0021 | 0.0099 | 0.2467 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0073 | 0.0853 | 1 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0025 | 0.0148 | 0.0146 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0021 | 0.0099 | 0.0552 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0146 | 0.1914 | 0.1913 |
Trichomonas vaginalis | chromobox protein, putative | 0.007 | 0.0814 | 0.224 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0029 | 0.0207 | 0.0205 |
Brugia malayi | MH2 domain containing protein | 0.0025 | 0.0148 | 0.0291 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 0.1114 | 0.1113 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0081 | 0.0969 | 0.1901 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0081 | 0.0969 | 0.0967 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0052 | 0.054 | 0.3038 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0228 | 0.0226 |
Mycobacterium ulcerans | hypothetical protein | 0.0073 | 0.0853 | 0.4503 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.0704 | 0.1382 |
Onchocerca volvulus | 0.005 | 0.0518 | 0.1311 | |
Schistosoma mansoni | smad | 0.0025 | 0.0148 | 0.0146 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0021 | 0.0099 | 0.2467 |
Onchocerca volvulus | Alhambra homolog | 0.0029 | 0.0207 | 0.0336 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0175 | 0.2341 | 0.4594 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0228 | 1 |
Schistosoma mansoni | Smad4 | 0.0025 | 0.0148 | 0.0146 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.0398 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0136 | 0.1772 | 1 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0185 | 0.0183 |
Brugia malayi | MH2 domain containing protein | 0.0025 | 0.0148 | 0.0291 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 0.1114 | 0.1113 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0362 | 0.0824 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0023 | 0.0045 |
Schistosoma mansoni | hypothetical protein | 0.0146 | 0.1914 | 0.1913 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0099 | 0.0195 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0398 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0185 | 0.0183 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0021 | 0.0099 | 0.0552 |
Plasmodium falciparum | phd finger protein, putative | 0.0029 | 0.0207 | 0.2219 |
Onchocerca volvulus | 0.0031 | 0.0238 | 0.0434 | |
Echinococcus multilocularis | chromobox protein 1 | 0.007 | 0.0814 | 0.0812 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0081 | 0.0969 | 0.0967 |
Echinococcus granulosus | chromobox protein 1 | 0.007 | 0.0814 | 0.0812 |
Schistosoma mansoni | lamin | 0.0027 | 0.0185 | 0.0183 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0035 | 0.0295 | 0.0579 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0518 | 0.1016 |
Entamoeba histolytica | hypothetical protein | 0.0146 | 0.1914 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0021 | 0.01 | 0.1154 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0025 | 0.0148 | 0.0291 |
Schistosoma mansoni | lamin | 0.0027 | 0.0185 | 0.0183 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.1114 | 0.1113 |
Brugia malayi | Heterochromatin protein 1 | 0.007 | 0.0814 | 0.1597 |
Brugia malayi | AMP-binding enzyme family protein | 0.0021 | 0.0099 | 0.0195 |
Brugia malayi | jmjC domain containing protein | 0.0035 | 0.0295 | 0.0579 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0969 | 0.0967 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0081 | 0.0969 | 0.0967 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.0406 | 0.0961 |
Mycobacterium tuberculosis | Toxin MazF3 | 0.0136 | 0.1772 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.1114 | 0.1113 |
Echinococcus multilocularis | Smad4 | 0.0025 | 0.0148 | 0.0146 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0052 | 0.054 | 0.3038 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0364 | 0.5095 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0228 | 0.0226 |
Onchocerca volvulus | 0.0073 | 0.0853 | 0.2362 | |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0583 | 0.1144 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0042 | 0.0398 | 0.0935 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0185 | 0.0183 |
Trichomonas vaginalis | chromobox protein, putative | 0.007 | 0.0814 | 0.224 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0185 | 0.0363 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0073 | 0.0853 | 0.4448 |
Echinococcus multilocularis | smad | 0.0025 | 0.0148 | 0.0146 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.0704 | 0.0703 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0035 | 0.0299 | 0.7519 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0228 | 0.0226 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0295 | 0.0293 |
Plasmodium vivax | hypothetical protein, conserved | 0.0029 | 0.0207 | 0.2219 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0228 | 0.0447 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.01 | 0.2481 |
Echinococcus multilocularis | jumonji domain containing protein | 0.004 | 0.0371 | 0.037 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.0704 | 0.1382 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0185 | 0.0363 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0185 | 0.0363 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0021 | 0.0099 | 0.2467 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0853 | 0.1673 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.0704 | 0.1382 |
Mycobacterium tuberculosis | Toxin MazF9 | 0.0136 | 0.1772 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0021 | 0.0099 | 0.0195 |
Schistosoma mansoni | eyes absent homolog | 0.0087 | 0.1057 | 0.1055 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0021 | 0.0099 | 0.0195 |
Schistosoma mansoni | chromobox protein | 0.007 | 0.0814 | 0.0812 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0017 | 0.0033 | 0.0792 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0207 | 0.0406 |
Echinococcus granulosus | Smad4 | 0.0025 | 0.0148 | 0.0146 |
Schistosoma mansoni | jumonji domain containing protein | 0.0075 | 0.088 | 0.0878 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0073 | 0.0853 | 0.4503 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 0.1114 | 0.1113 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0152 | 0.1095 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0704 | 0.0703 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0146 | 0.1914 | 0.1913 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0094 | 0.1163 | 0.1161 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0148 | 0.0146 |
Mycobacterium tuberculosis | PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0018 | 0.0056 | 0.0306 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0015 | 0.0002 | 0.0004 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.0021 | 0.0099 | 0.0098 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.0207 | 0.0205 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0969 | 0.1901 |
Brugia malayi | Pre-SET motif family protein | 0.0211 | 0.2863 | 0.5619 |
Giardia lamblia | PHD finger protein 15 | 0.0029 | 0.0207 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0185 | 0.0363 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0025 | 0.0148 | 0.0146 |
Echinococcus granulosus | jumonji domain containing protein | 0.004 | 0.0371 | 0.037 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0398 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0094 | 0.1163 | 0.1161 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0073 | 0.0853 | 0.4806 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0021 | 0.01 | 0.1154 |
Brugia malayi | Bromodomain containing protein | 0.0029 | 0.0207 | 0.0406 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0015 | 0.0002 | 0.0004 |
Brugia malayi | jmjC domain containing protein | 0.0094 | 0.1163 | 0.2283 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.1057 | 0.2074 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0059 | 0.0654 | 0.1284 |
Echinococcus granulosus | tumor protein p63 | 0.0342 | 0.4781 | 0.478 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0185 | 0.0363 |
Brugia malayi | AMP-binding enzyme family protein | 0.0021 | 0.0099 | 0.0195 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.2341 | 0.4594 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0211 | 0.2863 | 0.5619 |
Leishmania major | acetyl-CoA synthetase, putative | 0.0021 | 0.0099 | 0.1147 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.2341 | 0.2339 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0583 | 0.1144 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0969 | 0.0967 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0073 | 0.0853 | 1 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0025 | 0.0148 | 0.0146 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0146 | 0.1914 | 0.1913 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0073 | 0.0853 | 0.4503 |
Brugia malayi | MH2 domain containing protein | 0.0364 | 0.5095 | 1 |
Onchocerca volvulus | 0.024 | 0.3288 | 1 | |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0148 | 0.0146 |
Mycobacterium tuberculosis | Possible toxin MazF4 | 0.0136 | 0.1772 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0146 | 0.1914 | 1 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0021 | 0.0099 | 0.0098 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0152 | 0.177 |
Entamoeba histolytica | hypothetical protein | 0.0146 | 0.1914 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.005 | 0.0518 | 0.0516 |
Echinococcus granulosus | dna polymerase kappa | 0.0042 | 0.0398 | 0.0396 |
Mycobacterium tuberculosis | Possible toxin MazF7 | 0.0136 | 0.1772 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0081 | 0.0969 | 0.0967 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0185 | 0.0183 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.0398 | 1 |
Brugia malayi | Smad1 | 0.0025 | 0.0148 | 0.0291 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.0704 | 0.1382 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0853 | 0.1673 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0029 | 0.0207 | 0.8365 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.2285 | 0.2283 |
Brugia malayi | polk-prov protein | 0.0032 | 0.0249 | 0.0489 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0052 | 0.054 | 0.3038 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0025 | 0.0148 | 0.0146 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0073 | 0.0853 | 0.4806 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0704 | 0.0703 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0029 | 0.0207 | 0.0205 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0228 | 0.0226 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0256 | 0.3523 | 0.6915 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0256 | 0.3523 | 0.6915 |
Loa Loa (eye worm) | Smad1 | 0.0025 | 0.0148 | 0.0291 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0073 | 0.0853 | 0.4503 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0073 | 0.0853 | 0.4503 |
Brugia malayi | MH1 domain containing protein | 0.0025 | 0.0148 | 0.0291 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0042 | 0.0406 | 0.0961 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0152 | 0.1095 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0021 | 0.0099 | 0.2467 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0238 | 0.0467 |
Trichomonas vaginalis | set domain proteins, putative | 0.024 | 0.3288 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0025 | 0.0148 | 0.0291 |
Brugia malayi | AMP-binding enzyme family protein | 0.0073 | 0.0853 | 0.1673 |
Schistosoma mansoni | chromobox protein | 0.007 | 0.0814 | 0.0812 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0055 | 0.0583 | 0.3284 |
Mycobacterium ulcerans | hypothetical protein | 0.0136 | 0.1772 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0507 | 0.0995 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0015 | 0.0002 | 0.0004 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.0398 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0152 | 0.0299 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0002 | 0.0004 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0228 | 0.0226 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.0406 | 0.0961 |
Mycobacterium tuberculosis | Toxin MazF2 | 0.0136 | 0.1772 | 1 |
Leishmania major | long-chain-fatty-acid-CoA ligase, putative | 0.0021 | 0.0099 | 0.1147 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0583 | 0.1144 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0398 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.0704 | 0.1382 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0021 | 0.0099 | 0.2467 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0081 | 0.0969 | 0.1901 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0073 | 0.0853 | 0.4503 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0055 | 0.0583 | 0.2892 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0091 | 0.1114 | 0.2187 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.0194 | 0.0297 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.003 | 0.0228 | 0.0226 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0364 | 0.5095 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0249 | 0.0489 |
Trypanosoma brucei | unspecified product | 0.0035 | 0.0299 | 0.7519 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0073 | 0.0853 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0017 | 0.0033 | 0.0792 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0035 | 0.0295 | 0.0293 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0853 | 0.1673 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0021 | 0.0099 | 0.0552 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.1114 | 0.1113 |
Echinococcus granulosus | chromobox protein 1 | 0.007 | 0.0814 | 0.0812 |
Echinococcus multilocularis | geminin | 0.0171 | 0.2285 | 0.2283 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0021 | 0.0099 | 0.0552 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0042 | 0.0398 | 0.1783 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0099 | 0.0195 |
Echinococcus granulosus | geminin | 0.0171 | 0.2285 | 0.2283 |
Echinococcus granulosus | smad | 0.0025 | 0.0148 | 0.0146 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0021 | 0.0099 | 0.0195 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0073 | 0.0853 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0398 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0073 | 0.0853 | 0.4448 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0073 | 0.0853 | 0.4503 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0704 | 0.0703 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0021 | 0.0099 | 0.0552 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0021 | 0.0099 | 0.0195 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.007 | 0.0814 | 0.1597 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0021 | 0.0099 | 0.0552 |
Echinococcus multilocularis | chromobox protein 1 | 0.007 | 0.0814 | 0.0812 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0029 | 0.0207 | 0.0406 |
Echinococcus multilocularis | dna polymerase kappa | 0.0042 | 0.0398 | 0.0396 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0017 | 0.0033 | 0.0792 |
Mycobacterium tuberculosis | Possible toxin MazF1 | 0.0136 | 0.1772 | 1 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0021 | 0.0099 | 0.0552 |
Brugia malayi | AMP-binding enzyme family protein | 0.0021 | 0.0099 | 0.0195 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0211 | 0.021 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0081 | 0.0969 | 0.0967 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0021 | 0.0099 | 0.0552 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0362 | 0.0711 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0256 | 0.3523 | 0.6915 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0055 | 0.0583 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0152 | 0.4127 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0042 | 0.0398 | 0.0935 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0362 | 0.0824 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0704 | 0.0703 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.0021 | 0.0099 | 0.0195 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.0398 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0398 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0148 | 0.0146 |
Onchocerca volvulus | 0.0027 | 0.0185 | 0.0269 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 0.1114 | 0.1113 |
Leishmania major | acetyl-CoA synthetase, putative | 0.0021 | 0.0099 | 0.1147 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0073 | 0.0853 | 0.4503 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 0.7 microM | Cytotoxicity against human HT-29 cells after 72 hrs by SRB assay | ChEMBL. | 20067289 |
GI50 (functional) | = 1 microM | Cytotoxicity against human A549 cells after 72 hrs by SRB assay | ChEMBL. | 20067289 |
GI50 (functional) | = 2.4 microM | Cytotoxicity against human MDA-MB-231 cells after 72 hrs by SRB assay | ChEMBL. | 20067289 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.