Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0905 | 0.1473 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0908 | 0.1478 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0908 | 1 |
Onchocerca volvulus | 0.0035 | 0.0908 | 0.5 | |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0908 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0908 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0908 | 1 |
Brugia malayi | Augmenter of liver regeneration | 0.0033 | 0.0828 | 0.1348 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0908 | 0.1478 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0908 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0908 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0908 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0908 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0908 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0905 | 0.9966 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.6142 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0908 | 0.1478 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0908 | 0.1478 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0908 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0908 | 1 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0908 | 0.1478 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0908 | 0.1478 |
Echinococcus granulosus | FAD linked sulfhydryl oxidase ALR | 0.0033 | 0.0828 | 0.9123 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0908 | 0.5 |
Echinococcus multilocularis | FAD linked sulfhydryl oxidase ALR | 0.0033 | 0.0828 | 0.9123 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0908 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0908 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0908 | 0.5 |
Plasmodium falciparum | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0033 | 0.0828 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0908 | 0.1478 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.1684 | 0.2742 |
Loa Loa (eye worm) | hepatopoietin HPO2 | 0.0033 | 0.0828 | 0.1348 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0908 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.6142 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0908 | 0.1478 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0908 | 0.1478 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.1684 | 0.2742 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.1684 | 0.2742 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1684 | 0.2742 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0908 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0908 | 0.1478 |
Onchocerca volvulus | 0.0035 | 0.0908 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0908 | 0.1478 |
Onchocerca volvulus | 0.0035 | 0.0908 | 0.5 | |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0905 | 0.1473 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0908 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0908 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0908 | 0.1478 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0908 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0908 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0908 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.6142 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0908 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.